A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the initiation of apoptosis (programmed cell death).
A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins.
Any process involved in the maintenance of an internal equilibrium of copper ions within an organism or cell.
Any process that activates or increases the frequency, rate or extent of bone remodeling.
Any process that activates or increases the frequency, rate or extent of cell differentiation.
Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
Any process that activates or increases the frequency, rate or extent of macrophage differentiation.
Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.
Any process that activates or increases the frequency, rate or extent of the DNA-dependent transcription of a specific gene or genes.
Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor.
Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.
Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response.
Any process that activates or increases the frequency, rate, or extent of tissue remodeling.
Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.
Any process that modulates the DNA-dependent transcription of a specific gene or genes.
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.
Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
Any process that modulates the frequency, rate or extent of macrophage differentiation.
Any process that modulates the frequency, rate or extent of muscle development.
Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.
Any process that modulates the frequency, rate or extent of neuron differentiation.
Any process that modulates the frequency, rate or extent of protein binding.
Any process that modulates the frequency, rate or extent of protein kinase activity.
Any process that modulates the frequency, rate or extent of skeletal muscle development.
Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
Any process that modulates the frequency, rate or extent of striated muscle development.
Any process that modulates the frequency, rate or extent of the deposition of coloring matter occurring during development.
Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
Any process that modulates the frequency, rate, or extent of a homeostatic process.
Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.
Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
Any process that stops or reduces the activity of an enzyme.
Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.
Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
Any process that stops, prevents or reduces the frequency, rate or extent of caspase activity.
Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
Any process that stops, prevents, or reduces the frequency, rate, or extent of a homeostatic process.
Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).
The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
The deposition of coloring matter in an organism, tissue or cell, occurring during development.
The directed movement of organelles or molecules along microtubules in nerve cell axons.
The directed movement of organic anions into, out of, within or between cells. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.
The generation of a mature peptide hormone by posttranslational processing of a prohormone.
The hydrolysis of a peptide bond or bonds within a protein during protein maturation, the process leading to the attainment of the full functional capacity of a protein.
The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK.
The modification of peptidyl-lysine.
The posttranslational modification of a protein, particularly secretory proteins and proteins targeted for membranes or specific cellular locations.
The process by which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the tube extending from the mouth to the anus, including the pharynx, esophagus, stomach, and intestines.
The process by which the anatomical structures of the gut are generated and organized. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus.
The process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
The process leading to the attainment of the full functional capacity of a protein.
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.
The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.
The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.
The regrowth of lost or destroyed tissues.
The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone.
The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands.
The series of molecular signals generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB.
The specific actions or reactions of an organism that recur with a regularity of approximately 24 hours.