# go_term

go_id: GO:0021688
term: cerebellar molecular layer formation
ontology: BP
definition:
The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.


go_id: GO:0021689
term: cerebellar molecular layer structural organization
ontology: BP
definition:
The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.


go_id: GO:0021690
term: cerebellar molecular layer maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.


go_id: GO:0021691
term: cerebellar Purkinje cell layer maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


go_id: GO:0021692
term: cerebellar Purkinje cell layer morphogenesis
ontology: BP
definition:
The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


go_id: GO:0021693
term: cerebellar Purkinje cell layer structural organization
ontology: BP
definition:
The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


go_id: GO:0021694
term: cerebellar Purkinje cell layer formation
ontology: BP
definition:
The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


go_id: GO:0021695
term: cerebellar cortex development
ontology: BP
definition:
The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


go_id: GO:0021696
term: cerebellar cortex morphogenesis
ontology: BP
definition:
The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


go_id: GO:0021697
term: cerebellar cortex formation
ontology: BP
definition:
The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


go_id: GO:0021698
term: cerebellar cortex structural organization
ontology: BP
definition:
The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


go_id: GO:0021699
term: cerebellar cortex maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.


go_id: GO:0021700
term: developmental maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state.


go_id: GO:0021701
term: cerebellar Golgi cell differentiation
ontology: BP
definition:
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.


go_id: GO:0021702
term: cerebellar Purkinje cell differentiation
ontology: BP
definition:
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.


go_id: GO:0021703
term: locus ceruleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.


go_id: GO:0021704
term: locus ceruleus morphogenesis
ontology: BP
definition:
The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.


go_id: GO:0021705
term: locus ceruleus formation
ontology: BP
definition:
The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.


go_id: GO:0021706
term: locus ceruleus maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.


go_id: GO:0021707
term: cerebellar granule cell differentiation
ontology: BP
definition:
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.


go_id: GO:0021708
term: Lugaro cell differentiation
ontology: BP
definition:
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.


go_id: GO:0021709
term: cerebellar basket cell differentiation
ontology: BP
definition:
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.


go_id: GO:0021710
term: cerebellar stellate cell differentiation
ontology: BP
definition:
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.


go_id: GO:0021711
term: cerebellar unipolar brush cell differentiation
ontology: BP
definition:
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex.


go_id: GO:0021712
term: candelabrum cell differentiation
ontology: BP
definition:
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.


go_id: GO:0021713
term: inferior olivary nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements.


go_id: GO:0021714
term: inferior olivary nucleus morphogenesis
ontology: BP
definition:
The process in which the anatomical structure of the inferior olivary nucleus is generated and organized. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements.


go_id: GO:0021715
term: inferior olivary nucleus formation
ontology: BP
definition:
The process that gives rise to the inferior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements.


go_id: GO:0021716
term: inferior olivary nucleus structural organization
ontology: BP
definition:
The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements.


go_id: GO:0021717
term: inferior olivary nucleus maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for the inferior olivary nucleus to attain its fully functional state. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements.


go_id: GO:0021718
term: superior olivary nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.


go_id: GO:0021719
term: superior olivary nucleus morphogenesis
ontology: BP
definition:
The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.


go_id: GO:0021720
term: superior olivary nucleus formation
ontology: BP
definition:
The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.


go_id: GO:0021721
term: superior olivary nucleus structural organization
ontology: BP
definition:
The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.


go_id: GO:0021722
term: superior olivary nucleus maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.


go_id: GO:0021723
term: medullary reticular formation development
ontology: BP
definition:
The process whose specific outcome is the progression of the medullary reticular formation over time, from its formation to the mature structure. The medullary reticular formation is a series of brain nuclei located in the medulla oblongata.


go_id: GO:0021724
term: inferior raphe nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the inferior raphe nucleus over time, from its formation to the mature structure.


go_id: GO:0021725
term: superior raphe nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure.


go_id: GO:0021726
term: lateral reticular nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure.


go_id: GO:0021727
term: intermediate reticular formation development
ontology: BP
definition:
The process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure.


go_id: GO:0021728
term: inferior reticular formation development
ontology: BP
definition:
The process whose specific outcome is the progression of the inferior reticular formation over time, from its formation to the mature structure.


go_id: GO:0021729
term: superior reticular formation development
ontology: BP
definition:
The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure.


go_id: GO:0021730
term: trigeminal sensory nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure.


go_id: GO:0021731
term: trigeminal motor nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure.


go_id: GO:0021732
term: midbrain-hindbrain boundary maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.


go_id: GO:0021735
term: dentate nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure.


go_id: GO:0021736
term: globose nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure.


go_id: GO:0021737
term: emboliform nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure.


go_id: GO:0021738
term: fastigial nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure.


go_id: GO:0021739
term: mesencephalic trigeminal nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure.


go_id: GO:0021740
term: principal sensory nucleus of trigeminal nerve development
ontology: BP
definition:
The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure.


go_id: GO:0021741
term: spinal trigeminal nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure.


go_id: GO:0021742
term: abducens nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure.


go_id: GO:0021743
term: hypoglossal nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure.


go_id: GO:0021744
term: dorsal motor nucleus of vagus nerve development
ontology: BP
definition:
The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure.


go_id: GO:0021745
term: nucleus ambiguus development
ontology: BP
definition:
The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure.


go_id: GO:0021746
term: solitary nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure.


go_id: GO:0021747
term: cochlear nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure.


go_id: GO:0021748
term: dorsal cochlear nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure.


go_id: GO:0021749
term: ventral cochlear nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure.


go_id: GO:0021750
term: vestibular nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure.


go_id: GO:0021751
term: salivary nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure.


go_id: GO:0021752
term: inferior salivary nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure.


go_id: GO:0021753
term: superior salivary nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure.


go_id: GO:0021754
term: facial nucleus development
ontology: BP
definition:
The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure.


go_id: GO:0021755
term: eurydendroid cell differentiation
ontology: BP
definition:
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts.


go_id: GO:0021756
term: striatum development
ontology: BP
definition:
The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.


go_id: GO:0021757
term: caudate nucleus development
ontology: BP
definition:
The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain.


go_id: GO:0021758
term: putamen development
ontology: BP
definition:
The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain.


go_id: GO:0021759
term: globus pallidus development
ontology: BP
definition:
The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain.


go_id: GO:0021761
term: limbic system development
ontology: BP
definition:
The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory.


go_id: GO:0021762
term: substantia nigra development
ontology: BP
definition:
The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis).


go_id: GO:0021763
term: subthalamic nucleus development
ontology: BP
definition:
The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function.


go_id: GO:0021764
term: amygdala development
ontology: BP
definition:
The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure.


go_id: GO:0021765
term: cingulate gyrus development
ontology: BP
definition:
The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum.


go_id: GO:0021767
term: mammillary body development
ontology: BP
definition:
The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei.


go_id: GO:0021768
term: nucleus accumbens development
ontology: BP
definition:
The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia.


go_id: GO:0021769
term: orbitofrontal cortex development
ontology: BP
definition:
The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe.


go_id: GO:0021770
term: parahippocampal gyrus development
ontology: BP
definition:
The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex.


go_id: GO:0021771
term: lateral geniculate nucleus development
ontology: BP
definition:
The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina.


go_id: GO:0021772
term: olfactory bulb development
ontology: BP
definition:
The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex.


go_id: GO:0021773
term: striatal medium spiny neuron differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum.


go_id: GO:0021774
term: retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification
ontology: BP
definition:
The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.


go_id: GO:0021775
term: smoothened signaling pathway involved in ventral spinal cord interneuron specification
ontology: BP
definition:
The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.


go_id: GO:0021776
term: smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
ontology: BP
definition:
The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.


go_id: GO:0021777
term: BMP signaling pathway involved in spinal cord association neuron specification
ontology: BP
definition:
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to its commitment to an association neuron fate.


go_id: GO:0021778
term: oligodendrocyte cell fate specification
ontology: BP
definition:
The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.


go_id: GO:0021779
term: oligodendrocyte cell fate commitment
ontology: BP
definition:
The process in which the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte.


go_id: GO:0021780
term: glial cell fate specification
ontology: BP
definition:
The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.


go_id: GO:0021781
term: glial cell fate commitment
ontology: BP
definition:
The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell.


go_id: GO:0021782
term: glial cell development
ontology: BP
definition:
The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.


go_id: GO:0021783
term: preganglionic parasympathetic fiber development
ontology: BP
definition:
The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion.


go_id: GO:0021784
term: postganglionic parasympathetic fiber development
ontology: BP
definition:
The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.


go_id: GO:0021785
term: branchiomotor neuron axon guidance
ontology: BP
definition:
The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.


go_id: GO:0021786
term: branchiomotor neuron axon guidance in neural tube
ontology: BP
definition:
The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.


go_id: GO:0021787
term: chemorepulsion of branchiomotor neuron axon in neural tube
ontology: BP
definition:
The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.


go_id: GO:0021788
term: chemoattraction of branchiomotor neuron axon in neural tube
ontology: BP
definition:
The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.


go_id: GO:0021789
term: branchiomotor neuron axon guidance in branchial arch mesenchyme
ontology: BP
definition:
The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.


go_id: GO:0021790
term: chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme
ontology: BP
definition:
The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.


go_id: GO:0021791
term: chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme
ontology: BP
definition:
The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.


go_id: GO:0021792
term: chemoattraction of branchiomotor axon
ontology: BP
definition:
The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.


go_id: GO:0021793
term: chemorepulsion of branchiomotor axon
ontology: BP
definition:
The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.


go_id: GO:0021794
term: thalamus development
ontology: BP
definition:
The process in which the thalamus changes over time, from its initial formation to its mature state.


go_id: GO:0021796
term: cerebral cortex regionalization
ontology: BP
definition:
The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops.


go_id: GO:0021797
term: forebrain anterior/posterior pattern specification
ontology: BP
definition:
The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain.


go_id: GO:0021798
term: forebrain dorsal/ventral pattern formation
ontology: BP
definition:
The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain.


go_id: GO:0021799
term: cerebral cortex radially oriented cell migration
ontology: BP
definition:
The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain.


go_id: GO:0021800
term: cerebral cortex tangential migration
ontology: BP
definition:
The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.


go_id: GO:0021801
term: cerebral cortex radial glia guided migration
ontology: BP
definition:
The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex.


go_id: GO:0021802
term: somal translocation
ontology: BP
definition:
The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate.


go_id: GO:0021805
term: cell movement involved in somal translocation
ontology: BP
definition:
The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface.


go_id: GO:0021806
term: initiation of movement involved in cerebral cortex radial glia guided migration
ontology: BP
definition:
The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex.


go_id: GO:0021807
term: motogenic signaling initiating cell movement in cerebral cortex
ontology: BP
definition:
The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex.


go_id: GO:0021808
ontology: BP
term:
cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration

definition:
The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration.


go_id: GO:0021809
ontology: BP
term:
neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration

definition:
Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration.


go_id: GO:0021810
ontology: BP
term:
neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration

definition:
Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration.


go_id: GO:0021811
ontology: BP
term:
growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration

definition:
Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex.


go_id: GO:0021812
term: neuronal-glial interaction involved in cerebral cortex radial glia guided migration
ontology: BP
definition:
The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.


go_id: GO:0021813
ontology: BP
term:
cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration

definition:
The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex.


go_id: GO:0021814
term: cell motility involved in cerebral cortex radial glia guided migration
ontology: BP
definition:
The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration.


go_id: GO:0021815
term: modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration
ontology: BP
definition:
Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration.


go_id: GO:0021816
ontology: BP
term:
extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

definition:
The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells.


go_id: GO:0021817
term: nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
ontology: BP
definition:
The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration.


go_id: GO:0021818
ontology: BP
term:
modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration

definition:
The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.


go_id: GO:0021819
term: layer formation in cerebral cortex
ontology: BP
definition:
The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.


go_id: GO:0021820
ontology: BP
term:
extracellular matrix organization in marginal zone involved in cerebral cortex radial glia guided migration

definition:
The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells.


go_id: GO:0021821
term: negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination
ontology: BP
definition:
The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.


go_id: GO:0021822
term: negative regulation of cell motility involved in cerebral cortex radial glia guided migration
ontology: BP
definition:
The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex.


go_id: GO:0021823
term: cerebral cortex tangential migration using cell-cell interactions
ontology: BP
definition:
The process in which neurons interact with each other to promote migration along a tangential plane.


go_id: GO:0021824
term: cerebral cortex tangential migration using cell-axon interactions
ontology: BP
definition:
The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons.


go_id: GO:0021825
term: substrate-dependent cerebral cortex tangential migration
ontology: BP
definition:
The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions.


go_id: GO:0021826
term: substrate-independent telencephalic tangential migration
ontology: BP
definition:
The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact.


go_id: GO:0021827
term: postnatal olfactory bulb interneuron migration
ontology: BP
definition:
The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth.


go_id: GO:0021828
term: gonadotrophin-releasing hormone neuronal migration to the hypothalamus
ontology: BP
definition:
The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus.


go_id: GO:0021829
term: oligodendrocyte cell migration from the subpallium to the cortex
ontology: BP
definition:
The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development.


go_id: GO:0021830
term: interneuron migration from the subpallium to the cortex
ontology: BP
definition:
The directed movement of interneurons from the subpallium to the cortex during forebrain development.


go_id: GO:0021831
term: embryonic olfactory bulb interneuron precursor migration
ontology: BP
definition:
The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb.


go_id: GO:0021832
term: cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions
ontology: BP
definition:
The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration.


go_id: GO:0021833
term: cell-matrix adhesion involved in tangential migration using cell-cell interactions
ontology: BP
definition:
The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex.


go_id: GO:0021834
term: chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
ontology: BP
definition:
The creation and reception of signals that guide olfactory bulb interneuron precursors down concentration gradients towards the olfactory bulb.


go_id: GO:0021835
term: chemoattraction involved in embryonic olfactory bulb interneuron precursor migration
ontology: BP
definition:
The creation and reception of signals that result in the migration of interneuron precursors up a concentration gradient towards the olfactory bulb.


go_id: GO:0021836
term: chemorepulsion involved in postnatal olfactory bulb interneuron migration
ontology: BP
definition:
The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration.


go_id: GO:0021838
term: motogenic signaling involved in interneuron migration from the subpallium to the cortex
ontology: BP
definition:
The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex.


go_id: GO:0021839
ontology: BP
term:
interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex

definition:
The process in which migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex.


go_id: GO:0021840
term: directional guidance of interneurons involved in migration from the subpallium to the cortex
ontology: BP
definition:
The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex.


go_id: GO:0021841
term: chemoattraction involved in interneuron migration from the subpallium to the cortex
ontology: BP
definition:
The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex.


go_id: GO:0021842
term: chemorepulsion involved in interneuron migration from the subpallium to the cortex
ontology: BP
definition:
The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex.


go_id: GO:0021843
term: substrate-independent telencephalic tangential interneuron migration
ontology: BP
definition:
The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates.


go_id: GO:0021844
term: interneuron sorting involved in substrate-independent cerebral cortex tangential migration
ontology: BP
definition:
The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures.


go_id: GO:0021845
ontology: BP
term:
neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration

definition:
The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner.


go_id: GO:0021847
term: ventricular zone neuroblast division
ontology: BP
definition:
The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially.


go_id: GO:0021848
term: neuroblast division in subpallium
ontology: BP
definition:
The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially.


go_id: GO:0021849
term: neuroblast division in subventricular zone
ontology: BP
definition:
The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially.


go_id: GO:0021851
term: neuroblast division in dorsal lateral ganglionic eminence
ontology: BP
definition:
The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb.


go_id: GO:0021852
term: pyramidal neuron migration
ontology: BP
definition:
The migration of pyramidal a neuron precursor from the ventricular zone to the correct layer of the cerebral cortex.


go_id: GO:0021854
term: hypothalamus development
ontology: BP
definition:
The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.


go_id: GO:0021856
term: hypothalamic tangential migration using cell-axon interactions
ontology: BP
definition:
The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons.


go_id: GO:0021858
term: GABAergic neuron differentiation in basal ganglia
ontology: BP
definition:
The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron.


go_id: GO:0021859
term: pyramidal neuron differentiation
ontology: BP
definition:
The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron.


go_id: GO:0021861
term: forebrain radial glial cell differentiation
ontology: BP
definition:
The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.


go_id: GO:0021862
term: early neuron differentiation in forebrain
ontology: BP
definition:
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate.


go_id: GO:0021863
term: forebrain neuroblast differentiation
ontology: BP
definition:
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate.


go_id: GO:0021865
term: symmetric radial glial cell division in forebrain
ontology: BP
definition:
The mitotic division of a radial glial cell giving rise to two new radial glial cells in the forebrain.


go_id: GO:0021866
term: asymmetric radial glial cell division in forebrain
ontology: BP
definition:
The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type.


go_id: GO:0021867
term: neuron-producing asymmetric radial glial cell division in forebrain
ontology: BP
definition:
The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor.


go_id: GO:0021868
term: ventricular zone cell-producing asymmetric radial glial cell division in forebrain
ontology: BP
definition:
The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell.


go_id: GO:0021870
term: Cajal-Retzius cell differentiation
ontology: BP
definition:
The process in which a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene.


go_id: GO:0021871
term: forebrain regionalization
ontology: BP
definition:
The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops.


go_id: GO:0021872
term: forebrain generation of neurons
ontology: BP
definition:
The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons.


go_id: GO:0021873
term: forebrain neuroblast division
ontology: BP
definition:
The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast.


go_id: GO:0021874
term: Wnt signaling pathway involved in forebrain neuroblast division
ontology: BP
definition:
The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain.


go_id: GO:0021875
term: fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division
ontology: BP
definition:
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain.


go_id: GO:0021876
term: Notch signaling pathway involved in forebrain neuroblast division
ontology: BP
definition:
The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain.


go_id: GO:0021877
term: forebrain neuron fate commitment
ontology: BP
definition:
The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain.


go_id: GO:0021878
term: forebrain astrocyte fate commitment
ontology: BP
definition:
The process in which the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain.


go_id: GO:0021879
term: forebrain neuron differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.


go_id: GO:0021880
term: Notch signaling pathway involved in forebrain neuron fate commitment
ontology: BP
definition:
The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.


go_id: GO:0021881
term: Wnt-activated signaling pathway involved in forebrain neuron fate commitment
ontology: BP
definition:
The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain.


go_id: GO:0021882
ontology: BP
term:
regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment

definition:
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.


go_id: GO:0021883
term: cell cycle arrest of committed forebrain neuronal progenitor cell
ontology: BP
definition:
The process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) in a cell that has been committed to become a neuron that will reside in the forebrain.


go_id: GO:0021884
term: forebrain neuron development
ontology: BP
definition:
The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell.


go_id: GO:0021885
term: forebrain cell migration
ontology: BP
definition:
The orderly movement of a cell from one site to another at least one of which is located in the forebrain.


go_id: GO:0021886
term: hypothalamus gonadotrophin-releasing hormone neuron differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter.


go_id: GO:0021887
term: hypothalamus gonadotrophin-releasing hormone neuron fate commitment
ontology: BP
definition:
The process in which the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone.


go_id: GO:0021888
term: hypothalamus gonadotrophin-releasing hormone neuron development
ontology: BP
definition:
The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell.


go_id: GO:0021889
term: olfactory bulb interneuron differentiation
ontology: BP
definition:
The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb.


go_id: GO:0021890
term: olfactory bulb interneuron fate commitment
ontology: BP
definition:
The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb.


go_id: GO:0021891
term: olfactory bulb interneuron development
ontology: BP
definition:
The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell.


go_id: GO:0021892
term: cerebral cortex GABAergic interneuron differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex.


go_id: GO:0021893
term: cerebral cortex GABAergic interneuron fate commitment
ontology: BP
definition:
The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex.


go_id: GO:0021894
term: cerebral cortex GABAergic interneuron development
ontology: BP
definition:
The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell.


go_id: GO:0021895
term: cerebral cortex neuron differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.


go_id: GO:0021896
term: forebrain astrocyte differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.


go_id: GO:0021897
term: forebrain astrocyte development
ontology: BP
definition:
The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.


go_id: GO:0021898
term: commitment of multipotent stem cells to neuronal lineage in forebrain
ontology: BP
definition:
The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain.


go_id: GO:0021899
term: fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment
ontology: BP
definition:
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.


go_id: GO:0021900
term: ventricular zone cell fate commitment
ontology: BP
definition:
The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons.


go_id: GO:0021907
ontology: BP
term:
fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation

definition:
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.


go_id: GO:0021908
ontology: BP
term:
retinoic acid receptor signaling pathway involved in spinal cord anterior/posterior pattern formation

definition:
The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.


go_id: GO:0021909
ontology: BP
term:
regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning

definition:
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.


go_id: GO:0021910
term: smoothened signaling pathway involved in ventral spinal cord patterning
ontology: BP
definition:
The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord.


go_id: GO:0021911
term: retinoic acid metabolic process in spinal cord anterior-posterior patterning
ontology: BP
definition:
The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.


go_id: GO:0021912
ontology: BP
term:
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification

definition:
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord.


go_id: GO:0021913
ontology: BP
term:
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification

definition:
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord.


go_id: GO:0021914
term: negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord.


go_id: GO:0021915
term: neural tube development
ontology: BP
definition:
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.


go_id: GO:0021916
term: inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors
ontology: BP
definition:
Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis.


go_id: GO:0021917
term: somatic motor neuron fate commitment
ontology: BP
definition:
The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons.


go_id: GO:0021918
ontology: BP
term:
regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment

definition:
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis.


go_id: GO:0021919
term: BMP signaling pathway involved in spinal cord dorsal/ventral patterning
ontology: BP
definition:
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord.


go_id: GO:0021920
ontology: BP
term:
regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification

definition:
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord.


go_id: GO:0021921
term: regulation of cell proliferation in dorsal spinal cord
ontology: BP
definition:
The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord.


go_id: GO:0021922
term: Wnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord
ontology: BP
definition:
The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division.


go_id: GO:0021923
term: cell proliferation in hindbrain ventricular zone
ontology: BP
definition:
The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity.


go_id: GO:0021924
term: cell proliferation in external granule layer
ontology: BP
definition:
The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere.


go_id: GO:0021925
term: cerebellar Purkinje cell precursor proliferation
ontology: BP
definition:
The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.


go_id: GO:0021926
term: Golgi cell precursor proliferation
ontology: BP
definition:
The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.


go_id: GO:0021928
term: basket cell precursor proliferation
ontology: BP
definition:
The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.


go_id: GO:0021929
term: stellate cell precursor proliferation
ontology: BP
definition:
The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.


go_id: GO:0021930
term: cerebellar granule cell precursor proliferation
ontology: BP
definition:
The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.


go_id: GO:0021931
term: rostral hindbrain neuronal precursor cell proliferation
ontology: BP
definition:
The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus.


go_id: GO:0021932
term: hindbrain radial glia guided cell migration
ontology: BP
definition:
The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain.


go_id: GO:0021933
term: radial glia guided migration of cerebellar granule cell
ontology: BP
definition:
The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer.


go_id: GO:0021934
term: hindbrain tangential cell migration
ontology: BP
definition:
The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration.


go_id: GO:0021935
term: cerebellar granule cell precursor tangential migration
ontology: BP
definition:
The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium.


go_id: GO:0021937
ontology: BP
term:
cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation

definition:
The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation.


go_id: GO:0021938
ontology: BP
term:
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

definition:
The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells.


go_id: GO:0021939
ontology: BP
term:
extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation

definition:
The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation.


go_id: GO:0021941
term: negative regulation of cerebellar granule cell precursor proliferation
ontology: BP
definition:
The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation.


go_id: GO:0021942
term: radial glia guided migration of Purkinje cell
ontology: BP
definition:
The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer.


go_id: GO:0021943
term: formation of radial glial scaffolds
ontology: BP
definition:
The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells.


go_id: GO:0021944
term: neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration
ontology: BP
definition:
The changes in adhesion between a neuronal cell and a glial cell as a component of the process of hindbrain glial-mediated radial cell migration.


go_id: GO:0021945
term: positive regulation of cerebellar granule cell migration by calcium
ontology: BP
definition:
The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration.


go_id: GO:0021946
term: deep nuclear neuron cell migration
ontology: BP
definition:
The directed movement of a deep nuclear neuron from the ventricular zone to the deep hindbrain nuclei.


go_id: GO:0021947
term: outward migration of deep nuclear neurons
ontology: BP
definition:
The directed movement of a deep nuclear neuron from their ventrolateral origin to a rostrodorsal region of the cerebellar plate.


go_id: GO:0021948
term: inward migration of deep nuclear neurons
ontology: BP
definition:
The directed movement of a deep nuclear neuron from the rostrodorsal region of the cerebellar plate to their final more ventral position.


go_id: GO:0021949
term: brainstem precerebellar neuron precursor migration
ontology: BP
definition:
The early migration of a precerebellar neuronal precursor in which a cell move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem.


go_id: GO:0021950
term: chemorepulsion involved in precerebellar neuron migration
ontology: BP
definition:
The creation and reception of signals that repel a precerebellar neuron as a component of the process of tangential migration.


go_id: GO:0021951
term: chemoattraction involved in precerebellar neuron migration
ontology: BP
definition:
The creation and reception of signals that guide a precerebellar neuron towards their signals, where this process is involved in tangential migration.


go_id: GO:0021952
term: central nervous system projection neuron axonogenesis
ontology: BP
definition:
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.


go_id: GO:0021953
term: central nervous system neuron differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.


go_id: GO:0021954
term: central nervous system neuron development
ontology: BP
definition:
The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.


go_id: GO:0021955
term: central nervous system neuron axonogenesis
ontology: BP
definition:
Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells.


go_id: GO:0021956
term: central nervous system interneuron axonogenesis
ontology: BP
definition:
Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region.


go_id: GO:0021957
term: corticospinal tract morphogenesis
ontology: BP
definition:
Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract.


go_id: GO:0021958
term: gracilis tract morphogenesis
ontology: BP
definition:
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb.


go_id: GO:0021959
term: cuneatus tract morphogenesis
ontology: BP
definition:
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb.


go_id: GO:0021960
term: anterior commissure morphogenesis
ontology: BP
definition:
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum.


go_id: GO:0021961
term: posterior commissure morphogenesis
ontology: BP
definition:
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon.


go_id: GO:0021962
term: vestibulospinal tract morphogenesis
ontology: BP
definition:
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord.


go_id: GO:0021963
term: spinothalamic tract morphogenesis
ontology: BP
definition:
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling.


go_id: GO:0021964
term: rubrospinal tract morphogenesis
ontology: BP
definition:
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord.


go_id: GO:0021965
term: spinal cord ventral commissure morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized.


go_id: GO:0021966
term: corticospinal neuron axon guidance
ontology: BP
definition:
The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues.


go_id: GO:0021967
term: corticospinal neuron axon guidance through the cerebral cortex
ontology: BP
definition:
The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues.


go_id: GO:0021968
term: corticospinal neuron axon guidance through the internal capsule
ontology: BP
definition:
The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues.


go_id: GO:0021969
term: corticospinal neuron axon guidance through the cerebral peduncle
ontology: BP
definition:
The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues.


go_id: GO:0021970
term: corticospinal neuron axon guidance through the basilar pons
ontology: BP
definition:
The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues.


go_id: GO:0021971
term: corticospinal neuron axon guidance through the medullary pyramid
ontology: BP
definition:
The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues.


go_id: GO:0021972
term: corticospinal neuron axon guidance through spinal cord
ontology: BP
definition:
The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues.


go_id: GO:0021973
term: corticospinal neuron axon decussation
ontology: BP
definition:
The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side.


go_id: GO:0021974
term: trigeminothalamic tract morphogenesis
ontology: BP
definition:
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face.


go_id: GO:0021975
term: pons reticulospinal tract morphogenesis
ontology: BP
definition:
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord.


go_id: GO:0021976
term: medulla reticulospinal tract morphogenesis
ontology: BP
definition:
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord.


go_id: GO:0021977
term: tectospinal tract morphogenesis
ontology: BP
definition:
Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord.


go_id: GO:0021978
term: telencephalon regionalization
ontology: BP
definition:
The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops.


go_id: GO:0021979
term: hypothalamus cell differentiation
ontology: BP
definition:
The differentiation of cells that will contribute to the structure and function of the hypothalamus.


go_id: GO:0021981
term: subpallium radially oriented migration
ontology: BP
definition:
The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain.


go_id: GO:0021982
term: pineal gland development
ontology: BP
definition:
The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms.


go_id: GO:0021983
term: pituitary gland development
ontology: BP
definition:
The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.


go_id: GO:0021984
term: adenohypophysis development
ontology: BP
definition:
The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus.


go_id: GO:0021985
term: neurohypophysis development
ontology: BP
definition:
The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation.


go_id: GO:0021986
term: habenula development
ontology: BP
definition:
The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland.


go_id: GO:0021987
term: cerebral cortex development
ontology: BP
definition:
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.


go_id: GO:0021988
term: olfactory lobe development
ontology: BP
definition:
The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell.


go_id: GO:0021989
term: olfactory cortex development
ontology: BP
definition:
The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors.


go_id: GO:0021990
term: neural plate formation
ontology: BP
definition:
The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.


go_id: GO:0021991
term: neural plate thickening
ontology: BP
definition:
The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode.


go_id: GO:0021992
term: cell proliferation involved in neural plate elongation
ontology: BP
definition:
The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue.


go_id: GO:0021993
term: initiation of neural tube closure
ontology: BP
definition:
The process in which closure points are established at multiple points and along the neural rostrocaudal axis.


go_id: GO:0021996
term: lamina terminalis formation
ontology: BP
definition:
The process in which the anterior-most portion of the neural axis is formed by closure of the anterior neuropore.


go_id: GO:0021998
term: neural plate mediolateral regionalization
ontology: BP
definition:
The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate.


go_id: GO:0021999
term: neural plate anterior/posterior regionalization
ontology: BP
definition:
The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.


go_id: GO:0022000
term: forebrain induction by the anterior neural ridge
ontology: BP
definition:
The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate.


go_id: GO:0022001
term: negative regulation of anterior neural cell fate commitment of the neural plate
ontology: BP
definition:
Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate.


go_id: GO:0022002
ontology: BP
term:
negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway

definition:
The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell.


go_id: GO:0022003
ontology: BP
term:
negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway

definition:
The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.


go_id: GO:0022004
term: midbrain-hindbrain boundary maturation during brain development
ontology: BP
definition:
A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.


go_id: GO:0022005
term: midbrain-hindbrain boundary maturation during neural plate development
ontology: BP
definition:
A developmental process occurring before the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.


go_id: GO:0022006
term: zona limitans intrathalamica formation
ontology: BP
definition:
The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon.


go_id: GO:0022007
term: convergent extension involved in neural plate elongation
ontology: BP
definition:
The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate.


go_id: GO:0022009
term: central nervous system vasculogenesis
ontology: BP
definition:
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier.


go_id: GO:0022010
term: central nervous system myelination
ontology: BP
definition:
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.


go_id: GO:0022011
term: myelination in peripheral nervous system
ontology: BP
definition:
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.


go_id: GO:0022012
term: subpallium cell proliferation in forebrain
ontology: BP
definition:
The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population.


go_id: GO:0022013
term: pallium cell proliferation in forebrain
ontology: BP
definition:
The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population.


go_id: GO:0022014
term: radial glial cell division in subpallium
ontology: BP
definition:
The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes.


go_id: GO:0022015
term: radial glial cell division in pallium
ontology: BP
definition:
The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes.


go_id: GO:0022016
term: pallium glioblast division
ontology: BP
definition:
The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells.


go_id: GO:0022017
term: neuroblast division in pallium
ontology: BP
definition:
The division of neuroblasts in the pallium. Neuroblasts are precursor cells that give rise to neurons.


go_id: GO:0022018
term: lateral ganglionic eminence cell proliferation
ontology: BP
definition:
The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population.


go_id: GO:0022019
term: dorsal lateral ganglionic eminence cell proliferation
ontology: BP
definition:
The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population.


go_id: GO:0022020
term: medial ganglionic eminence cell proliferation
ontology: BP
definition:
The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population.


go_id: GO:0022021
term: caudal ganglionic eminence cell proliferation
ontology: BP
definition:
The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population.


go_id: GO:0022022
term: septal cell proliferation
ontology: BP
definition:
The multiplication or reproduction of septal cells, resulting in the expansion of a cell population.


go_id: GO:0022023
term: radial glial cell fate commitment in forebrain
ontology: BP
definition:
The process in which the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain.


go_id: GO:0022024
term: BMP signaling pathway involved in forebrain neuron fate commitment
ontology: BP
definition:
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.


go_id: GO:0022025
term: leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment
ontology: BP
definition:
Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.


go_id: GO:0022026
term: epidermal growth factor signaling pathway involved in forebrain neuron fate commitment
ontology: BP
definition:
The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.


go_id: GO:0022027
term: interkinetic nuclear migration
ontology: BP
definition:
The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle.


go_id: GO:0022028
term: tangential migration from the subventricular zone to the olfactory bulb
ontology: BP
definition:
The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.


go_id: GO:0022029
term: telencephalon cell migration
ontology: BP
definition:
The orderly movement of a cell from one site to another at least one of which is located in the telencephalon.


go_id: GO:0022032
term: telencephalon oligodendrocyte cell migration
ontology: BP
definition:
The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population.


go_id: GO:0022034
term: rhombomere cell proliferation
ontology: BP
definition:
The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population.


go_id: GO:0022035
term: rhombomere cell migration
ontology: BP
definition:
The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere.


go_id: GO:0022036
term: rhombomere cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a rhombomere cell.


go_id: GO:0022037
term: metencephalon development
ontology: BP
definition:
The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure.


go_id: GO:0022038
term: corpus callosum development
ontology: BP
definition:
The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.


go_id: GO:0022401
term: negative adaptation of signaling pathway
ontology: BP
definition:
The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.


go_id: GO:0022402
term: cell cycle process
ontology: BP
definition:
The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.


go_id: GO:0022403
term: cell cycle phase
ontology: BP
definition:
One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.


go_id: GO:0022404
term: molting cycle process
ontology: BP
definition:
A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin.


go_id: GO:0022405
term: hair cycle process
ontology: BP
definition:
A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.


go_id: GO:0022406
term: membrane docking
ontology: BP
definition:
The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.


go_id: GO:0022410
term: circadian sleep/wake cycle process
ontology: BP
definition:
A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.


go_id: GO:0022412
term: cellular process involved in reproduction in multicellular organism
ontology: BP
definition:
A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism.


go_id: GO:0022413
term: reproductive process in single-celled organism
ontology: BP
definition:
A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism.


go_id: GO:0022414
term: reproductive process
ontology: BP
definition:
A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.


go_id: GO:0022416
term: chaeta development
ontology: BP
definition:
The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.


go_id: GO:0022417
term: protein maturation by protein folding
ontology: BP
definition:
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein.


go_id: GO:0022600
term: digestive system process
ontology: BP
definition:
A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.


go_id: GO:0022601
term: menstrual cycle phase
ontology: BP
definition:
The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur.


go_id: GO:0022602
term: ovulation cycle process
ontology: BP
definition:
A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.


go_id: GO:0022604
term: regulation of cell morphogenesis
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.


go_id: GO:0022605
term: oogenesis stage
ontology: BP
definition:
A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell.


go_id: GO:0022611
term: dormancy process
ontology: BP
definition:
A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated.


go_id: GO:0022613
term: ribonucleoprotein complex biogenesis
ontology: BP
definition:
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex.


go_id: GO:0022614
term: membrane to membrane docking
ontology: BP
definition:
The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere.


go_id: GO:0022615
term: protein to membrane docking
ontology: BP
definition:
The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere.


go_id: GO:0022616
term: DNA strand elongation
ontology: BP
definition:
The DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand.


go_id: GO:0022618
term: ribonucleoprotein complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex.


go_id: GO:0022619
term: generative cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte.


go_id: GO:0022620
term: vegetative cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a vegetative cell. The vegetative cell is gives rise to the pollen tube.


go_id: GO:0022622
term: root system development
ontology: BP
definition:
The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure.


go_id: GO:0022623
term: proteasome-activating nucleotidase complex
ontology: CC
definition:
A homohexameric complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner.


go_id: GO:0022624
term: proteasome accessory complex
ontology: CC
definition:
A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.


go_id: GO:0022803
term: passive transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.


go_id: GO:0022804
term: active transmembrane transporter activity
ontology: MF
definition:
Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.


go_id: GO:0022809
term: mobile ion carrier activity
ontology: MF
definition:
This is a type of carrier produced by bacteria. It enables passive transport by shielding the ion that is being transported from the lipid membrane. It carries an ion across the membrane by enclosing the ion and travelling across the membrane. It does not form a fully open pore across the membrane.


go_id: GO:0022810
term: membrane potential driven uniporter activity
ontology: MF
definition:
Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


go_id: GO:0022814
term: facilitated diffusion
ontology: MF
definition:
Catalysis of the transfer of a single solute from one side of the membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged.


go_id: GO:0022891
term: substrate-specific transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.


go_id: GO:0022818
term: sodium ion uniporter activity
ontology: MF
definition:
Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


go_id: GO:0022819
term: potassium ion uniporter activity
ontology: MF
definition:
Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.


go_id: GO:0022820
term: potassium ion symporter activity
ontology: MF
definition:
Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.


go_id: GO:0022821
term: potassium ion antiporter activity
ontology: MF
definition:
Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.


go_id: GO:0022824
term: transmitter-gated ion channel activity
ontology: MF
definition:
Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts.


go_id: GO:0043682
term: copper-transporting ATPase activity
ontology: MF
definition:
Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+ = ADP + phosphate + Cu2+, directly driving the transport of the copper ions across a membrane.


go_id: GO:0022828
term: phosphorylation-gated channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts.


go_id: GO:0022829
term: wide pore channel activity
ontology: MF
definition:
Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.


go_id: GO:0022831
term: narrow pore, gated channel activity
ontology: MF
definition:
Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus.


go_id: GO:0022832
term: voltage-gated channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0022833
term: mechanically gated channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a solute by a channel that opens in response to a mechanical stress.


go_id: GO:0022834
term: ligand-gated channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.


go_id: GO:0022835
term: transmitter-gated channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts.


go_id: GO:0022836
term: gated channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.


go_id: GO:0022838
term: substrate-specific channel activity
ontology: MF
definition:
Enables the energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.


go_id: GO:0022839
term: ion gated channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus.


go_id: GO:0022840
term: leak channel activity
ontology: MF
definition:
Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.


go_id: GO:0022841
term: potassium ion leak channel activity
ontology: MF
definition:
Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state.


go_id: GO:0022842
term: narrow pore channel activity
ontology: MF
definition:
Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated.


go_id: GO:0022843
term: voltage-gated cation channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0022848
term: acetylcholine-gated cation channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a cation by a channel that opens when acetylcholine has been bound by the channel complex or one of its constituent parts.


go_id: GO:0022849
term: glutamate-gated calcium ion channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.


go_id: GO:0022850
term: serotonin-gated cation channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts.


go_id: GO:0022851
term: GABA-gated chloride ion channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts.


go_id: GO:0022852
term: glycine-gated chloride ion channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts.


go_id: GO:0022853
term: active ion transmembrane transporter activity
ontology: MF
definition:
Catalysis of the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction.


go_id: GO:0022855
term: protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022856
term: protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022858
term: alanine transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid.


go_id: GO:0022859
term: dephosphorylation-gated channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts.


go_id: GO:0022865
term: transmembrane electron transfer carrier
ontology: MF
definition:
Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics.


go_id: GO:0022869
term: protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022870
term: protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022871
term: protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022872
ontology: MF
term:
protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity

definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022873
term: protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022874
term: protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022875
ontology: MF
term:
protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity

definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022876
term: protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022877
term: protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022878
term: protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022879
term: protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022880
term: protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022881
term: protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022882
term: protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0022883
term: zinc efflux transmembrane transporter activity
ontology: MF
definition:
Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane.


go_id: GO:0022886
term: channel-forming ionophore activity
ontology: MF
definition:
Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive.


go_id: GO:0022889
term: serine transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid.


go_id: GO:0022890
term: inorganic cation transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.


go_id: GO:0022892
term: substrate-specific transporter activity
ontology: MF
definition:
Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.


go_id: GO:0022893
term: low-affinity tryptophan transmembrane transporter activity
ontology: MF
definition:
Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.


go_id: GO:0022894
term: Intermediate conductance calcium-activated potassium channel activity
ontology: MF
definition:
Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.


go_id: GO:0022897
term: proton-dependent peptide secondary active transmembrane transporter activity
ontology: MF
definition:
Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement.


go_id: GO:0023003
term: nuclear migration to the embryo sac center
ontology: BP
definition:
Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell.


go_id: GO:0060161
term: positive regulation of dopamine receptor signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the dopamine receptor protein signaling pathway. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.


go_id: GO:0030594
term: neurotransmitter receptor activity
ontology: MF
definition:
Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.


go_id: GO:0071230
term: cellular response to amino acid stimulus
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.


go_id: GO:0042101
term: T cell receptor complex
ontology: CC
definition:
A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.


go_id: GO:0042608
term: T cell receptor binding
ontology: MF
definition:
Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells.


go_id: GO:0050856
term: regulation of T cell receptor signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.


go_id: GO:0050862
term: positive regulation of T cell receptor signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.


go_id: GO:0023014
term: signal transduction by protein phosphorylation
ontology: BP
definition:
A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate.


go_id: GO:0023015
term: signal transduction by cis-phosphorylation
ontology: BP
definition:
A process in which the transfer of one or more phosphate groups by a kinase to a residue in the same kinase molecule transmits a signal. For example, ligand-binding can induce autophosphorylation of the activated receptor, creating binding sites for intracellular signaling molecules.


go_id: GO:0023016
term: signal transduction by trans-phosphorylation
ontology: BP
definition:
A process in which the transfer of one or more phosphate groups by a kinase to a residue in a different protein molecule transmits a signal.


go_id: GO:0023019
term: signal transduction involved in regulation of gene expression
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.


go_id: GO:0023021
term: termination of signal transduction
ontology: BP
definition:
The signaling process in which signal transduction is brought to an end rather than being reversibly modulated.


go_id: GO:0023022
term: termination of T cell signal transduction
ontology: BP
definition:
The signaling process in which T cell signal transduction is brought to an end rather than being reversibly modulated.


go_id: GO:0023027
term: MHC class I protein binding, via antigen binding groove
ontology: MF
definition:
Interacting selectively and non-covalently with major histocompatibility complex class I molecules via the antigen binding groove.


go_id: GO:0023028
term: MHC class I protein binding, via lateral surface
ontology: MF
definition:
Interacting selectively and non-covalently with major histocompatibility complex class I molecules via the lateral surface.


go_id: GO:0023029
term: MHC class Ib protein binding
ontology: MF
definition:
Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules.


go_id: GO:0023030
term: MHC class Ib protein binding, via antigen binding groove
ontology: MF
definition:
Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the antigen binding groove.


go_id: GO:0023031
term: MHC class Ib protein binding, via lateral surface
ontology: MF
definition:
Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the lateral surface.


go_id: GO:0023035
term: CD40 signaling pathway
ontology: BP
definition:
A series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038001
term: paracrine signaling
ontology: BP
definition:
The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other.


go_id: GO:0033554
term: cellular response to stress
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


go_id: GO:0023052
term: signaling
ontology: BP
definition:
The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.


go_id: GO:0023041
term: neuronal signal transduction
ontology: BP
definition:
The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular.


go_id: GO:0023045
term: signal transduction by conformational transition
ontology: BP
definition:
A process where induction of a conformational change in a molecule transmits a signal to that molecule.


go_id: GO:0070887
term: cellular response to chemical stimulus
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.


go_id: GO:0045125
term: bioactive lipid receptor activity
ontology: MF
definition:
Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes.


go_id: GO:0071260
term: cellular response to mechanical stimulus
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.


go_id: GO:0023056
term: positive regulation of signaling
ontology: BP
definition:
Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.


go_id: GO:0023058
term: adaptation of signaling pathway
ontology: BP
definition:
The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.


go_id: GO:0023059
term: positive adaptation of signaling pathway
ontology: BP
definition:
The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.


go_id: GO:0045056
term: transcytosis
ontology: BP
definition:
The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side.


go_id: GO:0030002
term: cellular anion homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of anions at the level of a cell.


go_id: GO:0030003
term: cellular cation homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of cations at the level of a cell.


go_id: GO:0030004
term: cellular monovalent inorganic cation homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell.


go_id: GO:0072503
term: cellular divalent inorganic cation homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of divalent cations at the level of a cell.


go_id: GO:0072504
term: cellular trivalent inorganic cation homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of trivalent cations at the level of a cell.


go_id: GO:0030007
term: cellular potassium ion homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.


go_id: GO:0030008
term: TRAPP complex
ontology: CC
definition:
A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active.


go_id: GO:0030014
term: CCR4-NOT complex
ontology: CC
definition:
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.


go_id: GO:0030015
term: CCR4-NOT core complex
ontology: CC
definition:
The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p.


go_id: GO:0030016
term: myofibril
ontology: CC
definition:
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.


go_id: GO:0030017
term: sarcomere
ontology: CC
definition:
The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.


go_id: GO:0030021
term: extracellular matrix structural constituent conferring compression resistance
ontology: MF
definition:
A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan.


go_id: GO:0030026
term: cellular manganese ion homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell.


go_id: GO:0030027
term: lamellipodium
ontology: CC
definition:
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.


go_id: GO:0030029
term: actin filament-based process
ontology: BP
definition:
Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.


go_id: GO:0030030
term: cell projection organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.


go_id: GO:0030033
term: microvillus assembly
ontology: BP
definition:
Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.


go_id: GO:0030035
term: microspike assembly
ontology: BP
definition:
Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell.


go_id: GO:0030037
term: actin filament reorganization involved in cell cycle
ontology: BP
definition:
The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs.


go_id: GO:0030038
term: contractile actin filament bundle assembly
ontology: BP
definition:
Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle.


go_id: GO:0030043
term: actin filament fragmentation
ontology: BP
definition:
The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins.


go_id: GO:0030046
term: parallel actin filament bundle assembly
ontology: BP
definition:
Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity.


go_id: GO:0030049
term: muscle filament sliding
ontology: BP
definition:
The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.


go_id: GO:0030054
term: cell junction
ontology: CC
definition:
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.


go_id: GO:0030056
term: hemidesmosome
ontology: CC
definition:
A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces.


go_id: GO:0030057
term: desmosome
ontology: CC
definition:
A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.


go_id: GO:0030059
term: aralkylamine dehydrogenase (azurin) activity
ontology: MF
definition:
Catalysis of the reaction: H(2)O + arCH(2)NH(2) + 2 azurin = 2 reduced azurin + ArCHO + NH(3). The symbol arCH(2)NH(2) represents an aralkylamine and ArCHO is an aryl aldehyde.


go_id: GO:0030061
term: mitochondrial crista
ontology: CC
definition:
Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria.


go_id: GO:0030062
term: mitochondrial tricarboxylic acid cycle enzyme complex
ontology: CC
definition:
Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle.


go_id: GO:0044659
term: cytolysis by virus of host cell
ontology: BP
definition:
The killing by a virus of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm.


go_id: GO:0030070
term: insulin processing
ontology: BP
definition:
The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges.


go_id: GO:0030071
term: regulation of mitotic metaphase/anaphase transition
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle.


go_id: GO:0030073
term: insulin secretion
ontology: BP
definition:
The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin.


go_id: GO:0030076
term: light-harvesting complex
ontology: CC
definition:
A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center.


go_id: GO:0030077
term: plasma membrane light-harvesting complex
ontology: CC
definition:
A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species.


go_id: GO:0030079
term: light-harvesting complex, peripheral complex
ontology: CC
definition:
Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center.


go_id: GO:0030080
term: B875 antenna complex
ontology: CC
definition:
Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm.


go_id: GO:0030081
term: B800-820 antenna complex
ontology: CC
definition:
Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex.


go_id: GO:0030082
term: B800-850 antenna complex
ontology: CC
definition:
Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex.


go_id: GO:0030083
term: PSI associated light-harvesting complex I, LHCIa subcomplex
ontology: CC
definition:
A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm.


go_id: GO:0030084
term: PSI associated light-harvesting complex I, LHCIb subcomplex
ontology: CC
definition:
A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm.


go_id: GO:0030085
term: PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex
ontology: CC
definition:
A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides.


go_id: GO:0030089
term: phycobilisome
ontology: CC
definition:
Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II.


go_id: GO:0030091
term: protein repair
ontology: BP
definition:
The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.


go_id: GO:0030093
term: chloroplast photosystem I
ontology: CC
definition:
Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana.


go_id: GO:0030094
term: plasma membrane-derived photosystem I
ontology: CC
definition:
A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species.


go_id: GO:0030095
term: chloroplast photosystem II
ontology: CC
definition:
An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone.


go_id: GO:0030096
term: plasma membrane-derived thylakoid photosystem II
ontology: CC
definition:
A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone.


go_id: GO:0030097
term: hemopoiesis
ontology: BP
definition:
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.


go_id: GO:0030098
term: lymphocyte differentiation
ontology: BP
definition:
The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.


go_id: GO:0030099
term: myeloid cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.


go_id: GO:0030101
term: natural killer cell activation
ontology: BP
definition:
The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.


go_id: GO:0030104
term: water homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of water within an organism or cell.


go_id: GO:0032393
term: MHC class I receptor activity
ontology: MF
definition:
Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.


go_id: GO:0030107
term: HLA-A specific inhibitory MHC class I receptor activity
ontology: MF
definition:
Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte.


go_id: GO:0030108
term: HLA-A specific activating MHC class I receptor activity
ontology: MF
definition:
Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte.


go_id: GO:0030109
term: HLA-B specific inhibitory MHC class I receptor activity
ontology: MF
definition:
Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte.


go_id: GO:0030110
term: HLA-C specific inhibitory MHC class I receptor activity
ontology: MF
definition:
Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte.


go_id: GO:0030111
term: regulation of Wnt signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway.


go_id: GO:0030114
term: slime layer
ontology: CC
definition:
A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids.


go_id: GO:0030116
term: glial cell-derived neurotrophic factor receptor binding
ontology: MF
definition:
A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors.


go_id: GO:0030117
term: membrane coat
ontology: CC
definition:
Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.


go_id: GO:0030118
term: clathrin coat
ontology: CC
definition:
A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes.


go_id: GO:0030123
term: AP-3 adaptor complex
ontology: CC
definition:
A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).


go_id: GO:0030124
term: AP-4 adaptor complex
ontology: CC
definition:
An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo.


go_id: GO:0030127
term: COPII vesicle coat
ontology: CC
definition:
One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.


go_id: GO:0030132
term: clathrin coat of coated pit
ontology: CC
definition:
The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex.


go_id: GO:0030135
term: coated vesicle
ontology: CC
definition:
Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.


go_id: GO:0030136
term: clathrin-coated vesicle
ontology: CC
definition:
A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.


go_id: GO:0030143
term: inter-Golgi transport vesicle
ontology: CC
definition:
A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack).


go_id: GO:0030144
term: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors.


go_id: GO:0030148
term: sphingolipid biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


go_id: GO:0030149
term: sphingolipid catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


go_id: GO:0030150
term: protein import into mitochondrial matrix
ontology: BP
definition:
The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.


go_id: GO:0030152
term: bacteriocin biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary.


go_id: GO:0030153
term: bacteriocin immunity
ontology: BP
definition:
A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary.


go_id: GO:0030154
term: cell differentiation
ontology: BP
definition:
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


go_id: GO:0030155
term: regulation of cell adhesion
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.


go_id: GO:0030157
term: pancreatic juice secretion
ontology: BP
definition:
The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.


go_id: GO:0030158
term: protein xylosyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate.


go_id: GO:0030159
term: receptor signaling complex scaffold activity
ontology: MF
definition:
Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.


go_id: GO:0030160
term: GKAP/Homer scaffold activity
ontology: MF
definition:
Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses.


go_id: GO:0030162
term: regulation of proteolysis
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.


go_id: GO:0030163
term: protein catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.


go_id: GO:0030164
term: protein denaturation
ontology: BP
definition:
Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds.


go_id: GO:0030165
term: PDZ domain binding
ontology: MF
definition:
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.


go_id: GO:0030166
term: proteoglycan biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


go_id: GO:0030167
term: proteoglycan catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.


go_id: GO:0030168
term: platelet activation
ontology: BP
definition:
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.


go_id: GO:0030169
term: low-density lipoprotein particle binding
ontology: MF
definition:
Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.


go_id: GO:0030170
term: pyridoxal phosphate binding
ontology: MF
definition:
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.


go_id: GO:0030171
term: voltage-gated proton channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0030172
term: troponin C binding
ontology: MF
definition:
Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex.


go_id: GO:0030173
term: integral component of Golgi membrane
ontology: CC
definition:
The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0030174
term: regulation of DNA-dependent DNA replication initiation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.


go_id: GO:0030175
term: filopodium
ontology: CC
definition:
Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.


go_id: GO:0030176
term: integral component of endoplasmic reticulum membrane
ontology: CC
definition:
The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0030178
term: negative regulation of Wnt signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.


go_id: GO:0030183
term: B cell differentiation
ontology: BP
definition:
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.


go_id: GO:0030184
term: nitric oxide transmembrane transporter activity
ontology: MF
definition:
Enables the directed movement of nitric oxide, nitrogen monoxide, from one side of a membrane to the other.


go_id: GO:0030185
term: nitric oxide transport
ontology: BP
definition:
The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0030187
term: melatonin biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine).


go_id: GO:0030198
term: extracellular matrix organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.


go_id: GO:0030199
term: collagen fibril organization
ontology: BP
definition:
Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.


go_id: GO:0030200
term: heparan sulfate proteoglycan catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.


go_id: GO:0030201
term: heparan sulfate proteoglycan metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.


go_id: GO:0030202
term: heparin metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.


go_id: GO:0030203
term: glycosaminoglycan metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties.


go_id: GO:0030204
term: chondroitin sulfate metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.


go_id: GO:0030205
term: dermatan sulfate metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues.


go_id: GO:0030206
term: chondroitin sulfate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.


go_id: GO:0030207
term: chondroitin sulfate catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.


go_id: GO:0030208
term: dermatan sulfate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.


go_id: GO:0030209
term: dermatan sulfate catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.


go_id: GO:0030210
term: heparin biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.


go_id: GO:0030211
term: heparin catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.


go_id: GO:0030212
term: hyaluronan metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.


go_id: GO:0030213
term: hyaluronan biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.


go_id: GO:0030214
term: hyaluronan catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.


go_id: GO:0030216
term: keratinocyte differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.


go_id: GO:0030217
term: T cell differentiation
ontology: BP
definition:
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.


go_id: GO:0030221
term: basophil differentiation
ontology: BP
definition:
The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell.


go_id: GO:0030222
term: eosinophil differentiation
ontology: BP
definition:
The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil.


go_id: GO:0030224
term: monocyte differentiation
ontology: BP
definition:
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.


go_id: GO:0030225
term: macrophage differentiation
ontology: BP
definition:
The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.


go_id: GO:0030229
term: very-low-density lipoprotein particle receptor activity
ontology: MF
definition:
Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis.


go_id: GO:0030228
term: lipoprotein particle receptor activity
ontology: MF
definition:
Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.


go_id: GO:0030232
term: insulin control element activator complex
ontology: CC
definition:
Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription.


go_id: GO:0030233
term: deoxynucleotide transmembrane transporter activity
ontology: MF
definition:
Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP.


go_id: GO:0030240
term: skeletal muscle thin filament assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle.


go_id: GO:0030241
term: skeletal muscle myosin thick filament assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle.


go_id: GO:0030242
term: pexophagy
ontology: BP
definition:
The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions.


go_id: GO:0030243
term: cellulose metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.


go_id: GO:0030244
term: cellulose biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.


go_id: GO:0030245
term: cellulose catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.


go_id: GO:0030247
term: polysaccharide binding
ontology: MF
definition:
Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.


go_id: GO:0030253
term: protein secretion by the type I secretion system
ontology: BP
definition:
The process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.


go_id: GO:0030254
term: protein secretion by the type III secretion system
ontology: BP
definition:
The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.


go_id: GO:0030255
term: protein secretion by the type IV secretion system
ontology: BP
definition:
The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system.


go_id: GO:0030256
term: type I protein secretion system complex
ontology: CC
definition:
A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space.


go_id: GO:0030257
term: type III protein secretion system complex
ontology: CC
definition:
A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase.


go_id: GO:0030258
term: lipid modification
ontology: BP
definition:
The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid.


go_id: GO:0030260
term: entry into host cell
ontology: BP
definition:
The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


go_id: GO:0030261
term: chromosome condensation
ontology: BP
definition:
The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.


go_id: GO:0030262
term: apoptotic nuclear changes
ontology: BP
definition:
Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.


go_id: GO:0030264
term: nuclear fragmentation involved in apoptotic nuclear change
ontology: BP
definition:
The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA.


go_id: GO:0030265
term: phospholipase C-activating rhodopsin mediated signaling pathway
ontology: BP
definition:
The series of molecular signals generated as a consequence of a rhodopsin molecule being activated by a photon, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).


go_id: GO:0030268
term: methylenetetrahydromethanopterin dehydrogenase activity
ontology: MF
definition:
Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420.


go_id: GO:0030269
term: tetrahydromethanopterin S-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM.


go_id: GO:0030270
term: formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H(+) = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran.


go_id: GO:0030272
term: 5-formyltetrahydrofolate cyclo-ligase activity
ontology: MF
definition:
Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate.


go_id: GO:0030273
term: melanin-concentrating hormone receptor activity
ontology: MF
definition:
Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity.


go_id: GO:0030274
term: LIM domain binding
ontology: MF
definition:
Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.


go_id: GO:0030276
term: clathrin binding
ontology: MF
definition:
Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.


go_id: GO:0030277
term: maintenance of gastrointestinal epithelium
ontology: BP
definition:
Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents.


go_id: GO:0030280
term: structural constituent of epidermis
ontology: MF
definition:
The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure.


go_id: GO:0030281
term: structural constituent of cutaneous appendage
ontology: MF
definition:
The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers.


go_id: GO:0030282
term: bone mineralization
ontology: BP
definition:
The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.


go_id: GO:0030284
term: estrogen receptor activity
ontology: MF
definition:
Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.


go_id: GO:0030285
term: integral component of synaptic vesicle membrane
ontology: CC
definition:
The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0030286
term: dynein complex
ontology: CC
definition:
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.


go_id: GO:0030287
term: cell wall-bounded periplasmic space
ontology: CC
definition:
The region between the plasma membrane and the cell wall, as found in organisms such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria.


go_id: GO:0030288
term: outer membrane-bounded periplasmic space
ontology: CC
definition:
The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall.


go_id: GO:0030289
term: protein phosphatase 4 complex
ontology: CC
definition:
A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits.


go_id: GO:0030290
term: sphingolipid activator protein activity
ontology: MF
definition:
Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase.


go_id: GO:0030296
term: protein tyrosine kinase activator activity
ontology: MF
definition:
Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.


go_id: GO:0030300
term: regulation of intestinal cholesterol absorption
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption.


go_id: GO:0030301
term: cholesterol transport
ontology: BP
definition:
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0030302
term: deoxynucleotide transport
ontology: BP
definition:
The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell.


go_id: GO:0030305
term: heparanase activity
ontology: MF
definition:
Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains.


go_id: GO:0030306
term: ADP-ribosylation factor binding
ontology: MF
definition:
Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells.


go_id: GO:0030308
term: negative regulation of cell growth
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.


go_id: GO:0030309
term: poly-N-acetyllactosamine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.


go_id: GO:0030310
term: poly-N-acetyllactosamine catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.


go_id: GO:0030311
term: poly-N-acetyllactosamine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.


go_id: GO:0030313
term: cell envelope
ontology: CC
definition:
An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.


go_id: GO:0030314
term: junctional membrane complex
ontology: CC
definition:
Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules).


go_id: GO:0030315
term: T-tubule
ontology: CC
definition:
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.


go_id: GO:0030316
term: osteoclast differentiation
ontology: BP
definition:
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.


go_id: GO:0072501
term: cellular divalent inorganic anion homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of divalent inorganic anions at the level of a cell.


go_id: GO:0072502
term: cellular trivalent inorganic anion homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of trivalent inorganic anions at the level of a cell.


go_id: GO:0030320
term: cellular monovalent inorganic anion homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell.


go_id: GO:0030322
term: stabilization of membrane potential
ontology: BP
definition:
The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


go_id: GO:0030323
term: respiratory tube development
ontology: BP
definition:
The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.


go_id: GO:0030324
term: lung development
ontology: BP
definition:
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.


go_id: GO:0030325
term: adrenal gland development
ontology: BP
definition:
The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.


go_id: GO:0030326
term: embryonic limb morphogenesis
ontology: BP
definition:
The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.


go_id: GO:0030328
term: prenylcysteine catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.


go_id: GO:0030329
term: prenylcysteine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.


go_id: GO:0030330
term: DNA damage response, signal transduction by p53 class mediator
ontology: BP
definition:
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.


go_id: GO:0030332
term: cyclin binding
ontology: MF
definition:
Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.


go_id: GO:0030337
term: DNA polymerase processivity factor activity
ontology: MF
definition:
An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.


go_id: GO:0030338
term: CMP-N-acetylneuraminate monooxygenase activity
ontology: MF
definition:
Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O.


go_id: GO:0030339
term: fatty-acyl-ethyl-ester synthase activity
ontology: MF
definition:
Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol.


go_id: GO:0030340
term: hyaluronate lyase activity
ontology: MF
definition:
Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine.


go_id: GO:0030341
term: chondroitin AC lyase activity
ontology: MF
definition:
Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups.


go_id: GO:0030342
term: 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
ontology: MF
definition:
Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol).


go_id: GO:0030350
term: iron-responsive element binding
ontology: MF
definition:
Interacting selectively and non-covalently with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins.


go_id: GO:0030351
term: inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
ontology: MF
definition:
Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate.


go_id: GO:0030352
term: inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
ontology: MF
definition:
Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate.


go_id: GO:0030353
term: fibroblast growth factor receptor antagonist activity
ontology: MF
definition:
Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist.


go_id: GO:0030354
term: melanin-concentrating hormone activity
ontology: MF
definition:
The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals.


go_id: GO:0030366
term: molybdopterin synthase activity
ontology: MF
definition:
Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis.


go_id: GO:0030368
term: interleukin-17 receptor activity
ontology: MF
definition:
Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0030369
term: ICAM-3 receptor activity
ontology: MF
definition:
Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues.


go_id: GO:0030370
term: intercellular adhesion molecule-3 receptor binding
ontology: MF
definition:
Interacting selectively and non-covalently with receptors for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1.


go_id: GO:0030372
term: high molecular weight B cell growth factor receptor binding
ontology: MF
definition:
Interacting selectively and non-covalently with the high molecular weight B cell growth factor receptor.


go_id: GO:0030373
term: high molecular weight B cell growth factor receptor activity
ontology: MF
definition:
Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity.


go_id: GO:0030374
term: ligand-dependent nuclear receptor transcription coactivator activity
ontology: MF
definition:
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.


go_id: GO:0030375
term: thyroid hormone receptor coactivator activity
ontology: MF
definition:
The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.


go_id: GO:0030379
term: neurotensin receptor activity, non-G-protein coupled
ontology: MF
definition:
Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins.


go_id: GO:0030381
term: chorion-containing eggshell pattern formation
ontology: BP
definition:
The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects.


go_id: GO:0030382
term: sperm mitochondrion organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm.


go_id: GO:0044403
term: symbiosis, encompassing mutualism through parasitism
ontology: BP
definition:
An interaction between two organisms living together in more or less intimate association. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs.


go_id: GO:0030385
term: ferredoxin:thioredoxin reductase activity
ontology: MF
definition:
Catalysis of the two-electron reduction of the disulfide of thioredoxins with electrons from ferredoxin involving a 4Fe-4S cluster and an adjacent active-site disulfide.


go_id: GO:0030388
term: fructose 1,6-bisphosphate metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis.


go_id: GO:0030389
term: fructosamine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.


go_id: GO:0030391
term: fructosamine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.


go_id: GO:0030392
term: fructosamine catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.


go_id: GO:0030393
term: fructoselysine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine group in place of a hydroxyl group.


go_id: GO:0030394
term: fructoseglycine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine group in place of a hydroxyl group.


go_id: GO:0030395
term: lactose binding
ontology: MF
definition:
Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk.


go_id: GO:0030398
term: peroxisomal membrane disassembly
ontology: BP
definition:
The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation.


go_id: GO:0030407
term: formimidoyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a formimino group from 5-formimidoyltetrahydrofolate to an acceptor molecule such as an amino acid.


go_id: GO:0030408
term: glycine formimidoyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine.


go_id: GO:0030409
term: glutamate formimidoyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.


go_id: GO:0030410
term: nicotianamine synthase activity
ontology: MF
definition:
Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H(+) + nicotianamine.


go_id: GO:0030412
term: formimidoyltetrahydrofolate cyclodeaminase activity
ontology: MF
definition:
Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+).


go_id: GO:0030413
term: competence pheromone activity
ontology: MF
definition:
A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence.


go_id: GO:0030417
term: nicotianamine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid.


go_id: GO:0030418
term: nicotianamine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid.


go_id: GO:0030419
term: nicotianamine catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid.


go_id: GO:0030420
term: establishment of competence for transformation
ontology: BP
definition:
The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation.


go_id: GO:0030422
term: production of siRNA involved in RNA interference
ontology: BP
definition:
Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.


go_id: GO:0030424
term: axon
ontology: CC
definition:
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.


go_id: GO:0030425
term: dendrite
ontology: CC
definition:
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.


go_id: GO:0030428
term: cell septum
ontology: CC
definition:
A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.


go_id: GO:0030431
term: sleep
ontology: BP
definition:
Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.


go_id: GO:0030432
term: peristalsis
ontology: BP
definition:
A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.


go_id: GO:0030433
term: ER-associated ubiquitin-dependent protein catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins.


go_id: GO:0030435
term: sporulation resulting in formation of a cellular spore
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.


go_id: GO:0030436
term: asexual sporulation
ontology: BP
definition:
The formation of spores derived from the products of mitosis. Examples of this process are found in Bacterial species.


go_id: GO:0030437
term: ascospore formation
ontology: BP
definition:
The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota).


go_id: GO:0030445
term: yeast-form cell wall
ontology: CC
definition:
The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form.


go_id: GO:0030447
term: filamentous growth
ontology: BP
definition:
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.


go_id: GO:0030448
term: hyphal growth
ontology: BP
definition:
Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls.


go_id: GO:0030450
term: regulation of complement activation, classical pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the classical pathway of complement activation.


go_id: GO:0030451
term: regulation of complement activation, alternative pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation.


go_id: GO:0051300
term: spindle pole body organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome.


go_id: GO:0030472
term: mitotic spindle organization in nucleus
ontology: BP
definition:
A process resulting in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle in the nucleus. The process occurs during a mitotic cell cycle and takes place at the cellular level.


go_id: GO:0030473
term: nuclear migration along microtubule
ontology: BP
definition:
The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.


go_id: GO:0030476
term: ascospore wall assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae.


go_id: GO:0030478
term: actin cap
ontology: CC
definition:
Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae.


go_id: GO:0030479
term: actin cortical patch
ontology: CC
definition:
An endocytic patch  that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae.


go_id: GO:0030487
term: inositol-4,5-bisphosphate 5-phosphatase activity
ontology: MF
definition:
Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.


go_id: GO:0030490
term: maturation of SSU-rRNA
ontology: BP
definition:
Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.


go_id: GO:0030491
term: heteroduplex formation
ontology: BP
definition:
The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules.


go_id: GO:0030492
term: hemoglobin binding
ontology: MF
definition:
Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.


go_id: GO:0030493
term: bacteriochlorophyll metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants.


go_id: GO:0030494
term: bacteriochlorophyll biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants.


go_id: GO:0030495
term: bacteriochlorophyll catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants.


go_id: GO:0030496
term: midbody
ontology: CC
definition:
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.


go_id: GO:0030505
term: inorganic diphosphate transport
ontology: BP
definition:
The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0030506
term: ankyrin binding
ontology: MF
definition:
Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.


go_id: GO:0030507
term: spectrin binding
ontology: MF
definition:
Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.


go_id: GO:0030509
term: BMP signaling pathway
ontology: BP
definition:
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0030510
term: regulation of BMP signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.


go_id: GO:0030511
term: positive regulation of transforming growth factor beta receptor signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.


go_id: GO:0030512
term: negative regulation of transforming growth factor beta receptor signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.


go_id: GO:0030513
term: positive regulation of BMP signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.


go_id: GO:0030514
term: negative regulation of BMP signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.


go_id: GO:0030518
term: intracellular steroid hormone receptor signaling pathway
ontology: BP
definition:
A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands.


go_id: GO:0030519
term: snoRNP binding
ontology: MF
definition:
Interacting selectively and non-covalently with any part of a small nucleolar ribonucleoprotein particle.


go_id: GO:0030520
term: intracellular estrogen receptor signaling pathway
ontology: BP
definition:
Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).


go_id: GO:0030538
term: embryonic genitalia morphogenesis
ontology: BP
definition:
The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized.


go_id: GO:0030539
term: male genitalia development
ontology: BP
definition:
The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure.


go_id: GO:0030540
term: female genitalia development
ontology: BP
definition:
The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure.


go_id: GO:0030543
term: 2-micrometer plasmid partitioning
ontology: BP
definition:
The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division.


go_id: GO:0030544
term: Hsp70 protein binding
ontology: MF
definition:
Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size.


go_id: GO:0030545
term: receptor regulator activity
ontology: MF
definition:
The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed.


go_id: GO:0030546
term: receptor activator activity
ontology: MF
definition:
The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased.


go_id: GO:0030547
term: receptor inhibitor activity
ontology: MF
definition:
The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased.


go_id: GO:0030548
term: acetylcholine receptor regulator activity
ontology: MF
definition:
Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed.


go_id: GO:0030549
term: acetylcholine receptor activator activity
ontology: MF
definition:
Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased.


go_id: GO:0030550
term: acetylcholine receptor inhibitor activity
ontology: MF
definition:
Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is decreased.


go_id: GO:0030551
term: cyclic nucleotide binding
ontology: MF
definition:
Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.


go_id: GO:0030552
term: cAMP binding
ontology: MF
definition:
Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).


go_id: GO:0030553
term: cGMP binding
ontology: MF
definition:
Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate).


go_id: GO:0030554
term: adenyl nucleotide binding
ontology: MF
definition:
Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.


go_id: GO:0030556
term: rRNA modification guide activity
ontology: MF
definition:
Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue.


go_id: GO:0030557
term: tRNA modification guide activity
ontology: MF
definition:
Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue.


go_id: GO:0030558
term: RNA pseudouridylation guide activity
ontology: MF
definition:
Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue.


go_id: GO:0030559
term: rRNA pseudouridylation guide activity
ontology: MF
definition:
Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue.


go_id: GO:0030560
term: tRNA pseudouridylation guide activity
ontology: MF
definition:
Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue.


go_id: GO:0030561
term: RNA 2'-O-ribose methylation guide activity
ontology: MF
definition:
Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue.


go_id: GO:0030562
term: rRNA 2'-O-ribose methylation guide activity
ontology: MF
definition:
Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue.


go_id: GO:0030563
term: snRNA 2'-O-ribose methylation guide activity
ontology: MF
definition:
Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule.


go_id: GO:0030564
term: tRNA 2'-O-ribose methylation guide activity
ontology: MF
definition:
Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue.


go_id: GO:0030565
term: snRNA pseudouridylation guide activity
ontology: MF
definition:
Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule.


go_id: GO:0030566
term: snRNA modification guide activity
ontology: MF
definition:
Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue.


go_id: GO:0030570
term: pectate lyase activity
ontology: MF
definition:
Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends.


go_id: GO:0030572
term: phosphatidyltransferase activity
ontology: MF
definition:
Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group.


go_id: GO:0030573
term: bile acid catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.


go_id: GO:0030574
term: collagen catabolic process
ontology: BP
definition:
The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.


go_id: GO:0030575
term: nuclear body organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.


go_id: GO:0030576
term: Cajal body organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors.


go_id: GO:0030577
term: Lands organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Lands, a class of nuclear body that react against SP140 auto-antibodies.


go_id: GO:0030578
term: PML body organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia).


go_id: GO:0030579
term: ubiquitin-dependent SMAD protein catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.


go_id: GO:0030580
term: quinone cofactor methyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1).


go_id: GO:0030581
term: symbiont intracellular protein transport in host
ontology: BP
definition:
The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


go_id: GO:0030582
term: fruiting body development
ontology: BP
definition:
The process whose specific outcome is the progression of the fruiting body over time, from its formation to the mature structure. A fruiting body is a multicellular structure that contains spores.


go_id: GO:0030583
term: myxococcal fruiting body development
ontology: BP
definition:
The process whose specific outcome is the progression of the myxococcal fruiting body over time, from its formation to the mature structure. The process begins when myxococci respond to a lack of nutrients in the environment and ends when the myxococcal fruiting body is a mature structure.


go_id: GO:0030584
term: sporocarp development
ontology: BP
definition:
The process whose specific outcome is the progression of a sporocarp over time, from its formation to the mature structure. The sporocarp is a spore bearing fruiting body organ. An example of this process is found in the Fungal species Coprinopsis cinerea.


go_id: GO:0030586
term: [methionine synthase] reductase activity
ontology: MF
definition:
Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+.


go_id: GO:0030587
term: sorocarp development
ontology: BP
definition:
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0030588
term: pseudocleavage
ontology: BP
definition:
Partial constriction of the cytoplasm of an embryo to form a furrow that resembles a cleavage furrow but does not complete cytokinesis.


go_id: GO:0030589
term: pseudocleavage involved in syncytial blastoderm formation
ontology: BP
definition:
Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster.


go_id: GO:0030590
term: first cell cycle pseudocleavage
ontology: BP
definition:
A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms.


go_id: GO:0030591
term: NAD DNA ADP-ribosyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form.


go_id: GO:0030592
term: DNA ADP-ribosylation
ontology: BP
definition:
The covalent attachment of an ADP-ribosyl group to the amino group at N2 of a 2'-deoxyguanosine residue in double-stranded DNA.


go_id: GO:0030593
term: neutrophil chemotaxis
ontology: BP
definition:
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.


go_id: GO:0030596
term: alpha-L-rhamnosidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.


go_id: GO:0030598
term: rRNA N-glycosylase activity
ontology: MF
definition:
Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species.


go_id: GO:0030604
term: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ontology: MF
definition:
Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH.


go_id: GO:0030612
term: arsenate reductase (thioredoxin) activity
ontology: MF
definition:
Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin.


go_id: GO:0030613
term: oxidoreductase activity, acting on phosphorus or arsenic in donors
ontology: MF
definition:
Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.


go_id: GO:0030614
term: oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor
ontology: MF
definition:
Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide.


go_id: GO:0030631
term: pyrrolysine incorporation
ontology: BP
definition:
The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases.


go_id: GO:0030632
term: D-alanine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid.


go_id: GO:0030633
term: D-alanine family amino acid catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids.


go_id: GO:0030634
term: carbon fixation by acetyl-CoA pathway
ontology: BP
definition:
A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2).


go_id: GO:1900619
term: acetate ester metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid.


go_id: GO:1900620
term: acetate ester biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid.


go_id: GO:0030638
term: polyketide metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps.


go_id: GO:0030640
term: polyketide catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps.


go_id: GO:0030641
term: regulation of cellular pH
ontology: BP
definition:
Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment.


go_id: GO:0030642
term: cellular sulfate ion homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of sulfate ions at the level of a cell.


go_id: GO:0030643
term: cellular phosphate ion homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of phosphate ions at the level of a cell.


go_id: GO:0030644
term: cellular chloride ion homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell.


go_id: GO:0030645
term: glucose catabolic process to butyrate
ontology: BP
definition:
The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum.


go_id: GO:0030647
term: aminoglycoside antibiotic metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin.


go_id: GO:0030648
term: aminoglycoside antibiotic biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin.


go_id: GO:0030649
term: aminoglycoside antibiotic catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin.


go_id: GO:0030651
term: peptide antibiotic biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity.


go_id: GO:0030652
term: peptide antibiotic catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity.


go_id: GO:0030653
term: beta-lactam antibiotic metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins.


go_id: GO:0030654
term: beta-lactam antibiotic biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins.


go_id: GO:0030655
term: beta-lactam antibiotic catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins.


go_id: GO:0030656
term: regulation of vitamin metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.


go_id: GO:0051196
term: regulation of coenzyme metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme.


go_id: GO:0051199
term: regulation of prosthetic group metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group.


go_id: GO:0030673
term: axolemma
ontology: CC
definition:
The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness.


go_id: GO:0030676
term: Rac guanyl-nucleotide exchange factor activity
ontology: MF
definition:
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.


go_id: GO:0030677
term: ribonuclease P complex
ontology: CC
definition:
A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs.


go_id: GO:0030678
term: mitochondrial ribonuclease P complex
ontology: CC
definition:
A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule.


go_id: GO:0030679
term: cyanelle ribonuclease P complex
ontology: CC
definition:
A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.


go_id: GO:0030680
term: dimeric ribonuclease P complex
ontology: CC
definition:
A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species.


go_id: GO:0030681
term: multimeric ribonuclease P complex
ontology: CC
definition:
A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species.


go_id: GO:0030682
term: evasion or tolerance of host defense response
ontology: BP
definition:
Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


go_id: GO:0030683
term: evasion or tolerance by virus of host immune response
ontology: BP
definition:
Any process, either active or passive, by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.


go_id: GO:0030684
term: preribosome
ontology: CC
definition:
Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis.


go_id: GO:0030685
term: nucleolar preribosome
ontology: CC
definition:
Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis.


go_id: GO:0030686
term: 90S preribosome
ontology: CC
definition:
A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.


go_id: GO:0030687
term: preribosome, large subunit precursor
ontology: CC
definition:
A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.


go_id: GO:0030688
term: preribosome, small subunit precursor
ontology: CC
definition:
A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.


go_id: GO:0030689
term: Noc complex
ontology: CC
definition:
Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis.


go_id: GO:0030690
term: Noc1p-Noc2p complex
ontology: CC
definition:
A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis.


go_id: GO:0030691
term: Noc2p-Noc3p complex
ontology: CC
definition:
A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis.


go_id: GO:0030692
term: Noc4p-Nop14p complex
ontology: CC
definition:
A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis.


go_id: GO:0030694
term: bacterial-type flagellum basal body, rod
ontology: CC
definition:
The central portion of the flagellar basal body, which spans the periplasm and threads through the rings. Examples of this component are found in Bacterial species.


go_id: GO:0030696
term: tRNA (m5U54) methyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule.


go_id: GO:0030697
term: S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes.


go_id: GO:0030698
term: 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. This occurs in most Gram-positive bacteria and some Gram-negative bacteria.


go_id: GO:0030699
term: glycine reductase activity
ontology: MF
definition:
Catalysis of the reaction: acetyl phosphate + H(2)O + NH(4)(+) + thioredoxin disulfide = glycine + H(+) + phosphate + thioredoxin.


go_id: GO:0030700
term: glycine reductase complex
ontology: CC
definition:
Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C.


go_id: GO:0030701
term: NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase].


go_id: GO:0030703
term: eggshell formation
ontology: BP
definition:
Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration.


go_id: GO:0030704
term: vitelline membrane formation
ontology: BP
definition:
Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg.


go_id: GO:0030705
term: cytoskeleton-dependent intracellular transport
ontology: BP
definition:
The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.


go_id: GO:0030706
term: germarium-derived oocyte differentiation
ontology: BP
definition:
The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster.


go_id: GO:0030707
term: ovarian follicle cell development
ontology: BP
definition:
The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.


go_id: GO:0030708
term: germarium-derived female germ-line cyst encapsulation
ontology: BP
definition:
Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster.


go_id: GO:0030709
term: border follicle cell delamination
ontology: BP
definition:
The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration.


go_id: GO:0030713
term: ovarian follicle cell stalk formation
ontology: BP
definition:
Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster.


go_id: GO:0030715
term: oocyte growth in germarium-derived egg chamber
ontology: BP
definition:
The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster.


go_id: GO:0030716
term: oocyte fate determination
ontology: BP
definition:
The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed.


go_id: GO:0030717
term: karyosome formation
ontology: BP
definition:
The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome.


go_id: GO:0030719
term: P granule organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.


go_id: GO:0030720
term: oocyte localization involved in germarium-derived egg chamber formation
ontology: BP
definition:
Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber.


go_id: GO:0030721
term: spectrosome organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome.


go_id: GO:0030722
term: establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification
ontology: BP
definition:
The directed movement of the nucleus to a specific location within the cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte. In the insect oocyte, for example, the nucleus is repositioned to a dorso-anterior position.


go_id: GO:0030723
term: ovarian fusome organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions.


go_id: GO:0030724
term: testicular fusome organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome.


go_id: GO:0030727
term: germarium-derived female germ-line cyst formation
ontology: BP
definition:
Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster.


go_id: GO:0030730
term: sequestering of triglyceride
ontology: BP
definition:
The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.


go_id: GO:0030731
term: guanidinoacetate N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H(+).


go_id: GO:0030732
term: methionine S-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine.


go_id: GO:0030733
term: fatty acid O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester.


go_id: GO:0030734
term: polysaccharide O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units.


go_id: GO:0030735
term: carnosine N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H(+).


go_id: GO:0030736
term: phenol O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H(+).


go_id: GO:0030737
term: iodophenol O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030738
term: tyramine N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030739
term: O-demethylpuromycin O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin.


go_id: GO:0030740
term: inositol 3-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030741
term: inositol 1-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030742
term: GTP-dependent protein binding
ontology: MF
definition:
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP.


go_id: GO:0030743
term: rRNA (adenosine-2'-O-)-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine.


go_id: GO:0030744
term: luteolin O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030745
term: dimethylhistidine N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine.


go_id: GO:0030746
term: isoflavone 4'-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone.


go_id: GO:0030747
term: indolepyruvate C-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate.


go_id: GO:0030748
term: amine N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine.


go_id: GO:0030749
term: loganate O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin.


go_id: GO:0030750
term: putrescine N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030751
term: licodione 2'-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2'-O-methyllicodione + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030752
term: 5-hydroxyfuranocoumarin 5-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin.


go_id: GO:0030753
term: 8-hydroxyfuranocoumarin 8-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin.


go_id: GO:0030754
term: apigenin 4'-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone.


go_id: GO:0030755
term: quercetin 3-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone.


go_id: GO:0030756
term: isoorientin 3'-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H(+) + isoscoparin.


go_id: GO:0030757
term: 3-methylquercitin 7-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine.


go_id: GO:0030758
term: 3,7-dimethylquercitin 4'-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030759
term: methylquercetagetin 6-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030760
term: pyridine N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine.


go_id: GO:0030761
term: 8-hydroxyquercitin 8-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030762
term: tetrahydrocolumbamine 2-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H(+) + tetrahydropalmatine.


go_id: GO:0030763
term: isobutyraldoxime O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030766
term: 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline.


go_id: GO:0030767
term: 3-hydroxyanthranilate 4-C-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030768
term: 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H(+).


go_id: GO:0030769
term: macrocin O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H(+) + tylosin.


go_id: GO:0030770
term: demethylmacrocin O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H(+) + macrocin.


go_id: GO:0030771
term: N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030772
term: tryptophan 2-C-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H(+).


go_id: GO:0030773
term: 6-hydroxymellein O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030774
term: anthranilate N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030775
term: glucuronoxylan 4-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate.


go_id: GO:0030776
term: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline.


go_id: GO:0030777
term: (S)-scoulerine 9-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030778
term: columbamine O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H(+) + palmatine.


go_id: GO:0030779
term: 10-hydroxydihydrosanguinarine 10-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H(+).


go_id: GO:0030780
term: 12-hydroxydihydrochelirubine 12-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H(+).


go_id: GO:0030781
term: 6-O-methylnorlaudanosoline 5'-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline.


go_id: GO:0030782
term: (S)-tetrahydroprotoberberine N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine.


go_id: GO:0030783
term: [cytochrome c]-methionine S-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine.


go_id: GO:0030784
term: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline.


go_id: GO:0030785
term: [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine.


go_id: GO:0030786
term: (RS)-norcoclaurine 6-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine.


go_id: GO:0030787
term: inositol 4-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030788
term: precorrin-2 C20-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H(+) + precorrin-3A.


go_id: GO:0030789
term: precorrin-3B C17-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4.


go_id: GO:0030790
term: chlorophenol O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole.


go_id: GO:0030791
term: arsenite methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.


go_id: GO:0030792
term: methylarsonite methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.


go_id: GO:0030793
term: 3'-demethylstaurosporine O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H(+) + staurosporine.


go_id: GO:0030794
term: (S)-coclaurine-N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine.


go_id: GO:0030795
term: jasmonate O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + jasmonate = S-adenosyl-L-homocysteine + methyljasmonate.


go_id: GO:0030796
term: cycloartenol 24-C-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030797
term: 24-methylenesterol C-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030798
term: trans-aconitate 2-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine.


go_id: GO:0030799
term: regulation of cyclic nucleotide metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides.


go_id: GO:0030800
term: negative regulation of cyclic nucleotide metabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides.


go_id: GO:0030801
term: positive regulation of cyclic nucleotide metabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides.


go_id: GO:0030802
term: regulation of cyclic nucleotide biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides.


go_id: GO:0030803
term: negative regulation of cyclic nucleotide biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides.


go_id: GO:0030804
term: positive regulation of cyclic nucleotide biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides.


go_id: GO:0030805
term: regulation of cyclic nucleotide catabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides.


go_id: GO:0030806
term: negative regulation of cyclic nucleotide catabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides.


go_id: GO:0030807
term: positive regulation of cyclic nucleotide catabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides.


go_id: GO:0030808
term: regulation of nucleotide biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.


go_id: GO:0030809
term: negative regulation of nucleotide biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.


go_id: GO:0030810
term: positive regulation of nucleotide biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.


go_id: GO:0030811
term: regulation of nucleotide catabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.


go_id: GO:0030812
term: negative regulation of nucleotide catabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.


go_id: GO:0030813
term: positive regulation of nucleotide catabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.


go_id: GO:0030814
term: regulation of cAMP metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).


go_id: GO:0030815
term: negative regulation of cAMP metabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).


go_id: GO:0030816
term: positive regulation of cAMP metabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).


go_id: GO:0030817
term: regulation of cAMP biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).


go_id: GO:0030818
term: negative regulation of cAMP biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).


go_id: GO:0030819
term: positive regulation of cAMP biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).


go_id: GO:0030820
term: regulation of cAMP catabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).


go_id: GO:0030821
term: negative regulation of cAMP catabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).


go_id: GO:0030822
term: positive regulation of cAMP catabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).


go_id: GO:0030823
term: regulation of cGMP metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP.


go_id: GO:0030824
term: negative regulation of cGMP metabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cGMP.


go_id: GO:0030825
term: positive regulation of cGMP metabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cGMP.


go_id: GO:0030826
term: regulation of cGMP biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP.


go_id: GO:0030827
term: negative regulation of cGMP biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP.


go_id: GO:0030828
term: positive regulation of cGMP biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP.


go_id: GO:0030829
term: regulation of cGMP catabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP.


go_id: GO:0030830
term: negative regulation of cGMP catabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP.


go_id: GO:0030831
term: positive regulation of cGMP catabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP.


go_id: GO:0030833
term: regulation of actin filament polymerization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.


go_id: GO:0030834
term: regulation of actin filament depolymerization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament.


go_id: GO:0030835
term: negative regulation of actin filament depolymerization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.


go_id: GO:0030839
term: regulation of intermediate filament polymerization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament.


go_id: GO:0030840
term: negative regulation of intermediate filament polymerization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization.


go_id: GO:0030841
term: positive regulation of intermediate filament polymerization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization.


go_id: GO:0030842
term: regulation of intermediate filament depolymerization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament.


go_id: GO:0030843
term: negative regulation of intermediate filament depolymerization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament depolymerization.


go_id: GO:0030844
term: positive regulation of intermediate filament depolymerization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization.


go_id: GO:0030845
term: phospholipase C-inhibiting G-protein coupled receptor signaling pathway
ontology: BP
definition:
A G-protein coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG).


go_id: GO:0030846
term: termination of RNA polymerase II transcription, poly(A)-coupled
ontology: BP
definition:
The process in which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3' end is coupled to transcription termination.


go_id: GO:0030847
term: termination of RNA polymerase II transcription, exosome-dependent
ontology: BP
definition:
The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end.


go_id: GO:0030850
term: prostate gland development
ontology: BP
definition:
The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.


go_id: GO:0030851
term: granulocyte differentiation
ontology: BP
definition:
The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.


go_id: GO:0030853
term: negative regulation of granulocyte differentiation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.


go_id: GO:0030854
term: positive regulation of granulocyte differentiation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.


go_id: GO:0030855
term: epithelial cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.


go_id: GO:0030857
term: negative regulation of epithelial cell differentiation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.


go_id: GO:0030858
term: positive regulation of epithelial cell differentiation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.


go_id: GO:0030859
term: polarized epithelial cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis.


go_id: GO:0030860
term: regulation of polarized epithelial cell differentiation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation.


go_id: GO:0030861
term: negative regulation of polarized epithelial cell differentiation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation.


go_id: GO:0030862
term: positive regulation of polarized epithelial cell differentiation
ontology: BP
definition:
Any process that activates or increases the rate or extent of polarized epithelial cell differentiation.


go_id: GO:0030864
term: cortical actin cytoskeleton
ontology: CC
definition:
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.


go_id: GO:0030865
term: cortical cytoskeleton organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.


go_id: GO:0030866
term: cortical actin cytoskeleton organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.


go_id: GO:0030869
term: RENT complex
ontology: CC
definition:
A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit.


go_id: GO:0030870
term: Mre11 complex
ontology: CC
definition:
Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.


go_id: GO:0030874
term: nucleolar chromatin
ontology: CC
definition:
The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA.


go_id: GO:0030875
term: rDNA protrusion
ontology: CC
definition:
Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining.


go_id: GO:0030877
term: beta-catenin destruction complex
ontology: CC
definition:
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.


go_id: GO:0030878
term: thyroid gland development
ontology: BP
definition:
The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone.


go_id: GO:0030879
term: mammary gland development
ontology: BP
definition:
The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.


go_id: GO:0030880
term: RNA polymerase complex
ontology: CC
definition:
Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits.


go_id: GO:0030884
term: exogenous lipid antigen binding
ontology: MF
definition:
Interacting selectively and non-covalently with an exogenous lipid antigen (examples include microbial lipids and glycolipids).


go_id: GO:0030886
term: negative regulation of myeloid dendritic cell activation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.


go_id: GO:0030891
term: VCB complex
ontology: CC
definition:
A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.


go_id: GO:0030892
term: mitotic cohesin complex
ontology: CC
definition:
A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex.


go_id: GO:0030893
term: meiotic cohesin complex
ontology: CC
definition:
A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.


go_id: GO:0030894
term: replisome
ontology: CC
definition:
A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.


go_id: GO:0030895
term: apolipoprotein B mRNA editing enzyme complex
ontology: CC
definition:
Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP).


go_id: GO:0030896
term: checkpoint clamp complex
ontology: CC
definition:
Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage.


go_id: GO:0030897
term: HOPS complex
ontology: CC
definition:
A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion.


go_id: GO:0030898
term: actin-dependent ATPase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate.


go_id: GO:0030899
term: calcium-dependent ATPase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+).


go_id: GO:0030900
term: forebrain development
ontology: BP
definition:
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).


go_id: GO:0030901
term: midbrain development
ontology: BP
definition:
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).


go_id: GO:0030902
term: hindbrain development
ontology: BP
definition:
The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).


go_id: GO:0030903
term: notochord development
ontology: BP
definition:
The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.


go_id: GO:0030904
term: retromer complex
ontology: CC
definition:
A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p.


go_id: GO:0030905
term: retromer complex, outer shell
ontology: CC
definition:
One of two subcomplexes that combine to form the retromer, believed to be peripherally associated with the membrane. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer.


go_id: GO:0030906
term: retromer complex, inner shell
ontology: CC
definition:
One of two subcomplexes that combine to form the retromer, believed to be closely associated with the membrane. In budding yeast the complex comprises Vps35p, Vps29p, and Vps26p.


go_id: GO:0030907
term: MBF transcription complex
ontology: CC
definition:
A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi4p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p.


go_id: GO:0030909
term: non-intein-mediated protein splicing
ontology: BP
definition:
The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins.


go_id: GO:0030910
term: olfactory placode formation
ontology: BP
definition:
The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.


go_id: GO:0030911
term: TPR domain binding
ontology: MF
definition:
Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices.


go_id: GO:0030912
term: response to deep water
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle.


go_id: GO:0030913
term: paranodal junction assembly
ontology: BP
definition:
Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier.


go_id: GO:0030914
term: STAGA complex
ontology: CC
definition:
A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs.


go_id: GO:0030915
term: Smc5-Smc6 complex
ontology: CC
definition:
A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans.


go_id: GO:0030916
term: otic vesicle formation
ontology: BP
definition:
The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear.


go_id: GO:0030917
term: midbrain-hindbrain boundary development
ontology: BP
definition:
The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.


go_id: GO:0030921
term: peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine
ontology: BP
definition:
The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues.


go_id: GO:0030922
term: peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine
ontology: BP
definition:
The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues.


go_id: GO:0030923
term: metal incorporation into metallo-oxygen cluster
ontology: BP
definition:
The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate.


go_id: GO:0030926
ontology: BP
term:
calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide

definition:
The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site.


go_id: GO:0030927
ontology: BP
term:
manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide

definition:
The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site.


go_id: GO:0030929
term: ADPG pyrophosphorylase complex
ontology: CC
definition:
Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits.


go_id: GO:0030930
term: homotetrameric ADPG pyrophosphorylase complex
ontology: CC
definition:
A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species.


go_id: GO:0030931
term: heterotetrameric ADPG pyrophosphorylase complex
ontology: CC
definition:
A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus.


go_id: GO:0030934
term: anchoring collagen complex
ontology: CC
definition:
Any collagen complex which links one collagen assembly, such as a collagen fibril or sheet, to other structures.


go_id: GO:0030937
term: collagen type XVII trimer
ontology: CC
definition:
A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices span the plasma membrane and associate with hemidesmosomes and the basal lamina where they bind laminin.


go_id: GO:0048571
term: long-day photoperiodism
ontology: BP
definition:
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that exceeds a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical day length.


go_id: GO:0048572
term: short-day photoperiodism
ontology: BP
definition:
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that falls short of a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 hours minus the critical day length.


go_id: GO:0030941
term: chloroplast targeting sequence binding
ontology: MF
definition:
Interacting selectively and non-covalently with a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast.


go_id: GO:0030942
term: endoplasmic reticulum signal peptide binding
ontology: MF
definition:
Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.


go_id: GO:0030943
term: mitochondrion targeting sequence binding
ontology: MF
definition:
Interacting selectively and non-covalently with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion.


go_id: GO:0030944
term: DDEL sequence binding
ontology: MF
definition:
Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.


go_id: GO:0030945
term: protein tyrosine phosphatase activity, via thiol-phosphate intermediate
ontology: MF
definition:
The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate.


go_id: GO:0030946
term: protein tyrosine phosphatase activity, metal-dependent
ontology: MF
definition:
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions.


go_id: GO:0030947
term: regulation of vascular endothelial growth factor receptor signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.


go_id: GO:0030948
term: negative regulation of vascular endothelial growth factor receptor signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.


go_id: GO:0030949
term: positive regulation of vascular endothelial growth factor receptor signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.


go_id: GO:0030950
term: establishment or maintenance of actin cytoskeleton polarity
ontology: BP
definition:
Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures.


go_id: GO:0030951
term: establishment or maintenance of microtubule cytoskeleton polarity
ontology: BP
definition:
Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures.


go_id: GO:0030952
term: establishment or maintenance of cytoskeleton polarity
ontology: BP
definition:
Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures.


go_id: GO:0030953
term: astral microtubule organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.


go_id: GO:0030954
term: astral microtubule nucleation
ontology: BP
definition:
The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule.


go_id: GO:0030956
term: glutamyl-tRNA(Gln) amidotransferase complex
ontology: CC
definition:
A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms.


go_id: GO:0030957
term: Tat protein binding
ontology: MF
definition:
Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus.


go_id: GO:0030958
term: RITS complex
ontology: CC
definition:
A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing.


go_id: GO:0030959
term: peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine
ontology: BP
definition:
The modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link.


go_id: GO:0030960
term: peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine
ontology: BP
definition:
The modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link.


go_id: GO:0030964
term: NADH dehydrogenase complex
ontology: CC
definition:
An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.


go_id: GO:0030965
term: plasma membrane electron transport, NADH to quinone
ontology: BP
definition:
The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase.


go_id: GO:0030968
term: endoplasmic reticulum unfolded protein response
ontology: BP
definition:
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.


go_id: GO:0030970
term: retrograde protein transport, ER to cytosol
ontology: BP
definition:
The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.


go_id: GO:0030974
term: thiamine pyrophosphate transport
ontology: BP
definition:
The directed movement of thiamine pyrophosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0030975
term: thiamine binding
ontology: MF
definition:
Interacting selectively and non-covalently with thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.


go_id: GO:0030976
term: thiamine pyrophosphate binding
ontology: MF
definition:
Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.


go_id: GO:0030978
term: alpha-glucan metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds.


go_id: GO:0030979
term: alpha-glucan biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds.


go_id: GO:0030982
term: adventurous gliding motility
ontology: BP
definition:
A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime.


go_id: GO:0030983
term: mismatched DNA binding
ontology: MF
definition:
Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches.


go_id: GO:0030984
term: kininogen binding
ontology: MF
definition:
Interacting selectively and non-covalently with a kininogen, any of a group of plasma proteins that are kinin precursors.


go_id: GO:0030988
term: high molecular weight kininogen receptor complex
ontology: CC
definition:
A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins.


go_id: GO:0030989
term: dynein-driven meiotic oscillatory nuclear movement
ontology: BP
definition:
Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein.


go_id: GO:0030990
term: intraciliary transport particle
ontology: CC
definition:
A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.


go_id: GO:0030991
term: intraciliary transport particle A
ontology: CC
definition:
The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa.


go_id: GO:0030992
term: intraciliary transport particle B
ontology: CC
definition:
The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa.


go_id: GO:0030993
term: axonemal heterotrimeric kinesin-II complex
ontology: CC
definition:
A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme.


go_id: GO:0030995
term: cell septum edging catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation.


go_id: GO:0030996
term: mitotic cell cycle arrest in response to nitrogen starvation
ontology: BP
definition:
The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of nitrogen.


go_id: GO:0030997
term: regulation of centriole-centriole cohesion
ontology: BP
definition:
Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker.


go_id: GO:0030998
term: linear element
ontology: CC
definition:
A proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. Linear elements have a structure related to but not equivalent to the synaptonemal complex.


go_id: GO:0030999
term: linear element assembly
ontology: BP
definition:
The cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase.


go_id: GO:0031000
term: response to caffeine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.


go_id: GO:0031001
term: response to brefeldin A
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus.


go_id: GO:0031002
term: actin rod
ontology: CC
definition:
A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Found in the germinating spores of Dictyostelium discoideum.


go_id: GO:0031003
term: actin tubule
ontology: CC
definition:
A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together.


go_id: GO:0031004
term: potassium ion-transporting ATPase complex
ontology: CC
definition:
Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex.


go_id: GO:0031005
term: filamin binding
ontology: MF
definition:
Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.


go_id: GO:0031010
term: ISWI-type complex
ontology: CC
definition:
Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair.


go_id: GO:0031011
term: Ino80 complex
ontology: CC
definition:
A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity.


go_id: GO:0031012
term: extracellular matrix
ontology: CC
definition:
A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants).


go_id: GO:0031013
term: troponin I binding
ontology: MF
definition:
Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex.


go_id: GO:0031014
term: troponin T binding
ontology: MF
definition:
Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex.


go_id: GO:0044613
term: nuclear pore central transport channel
ontology: CC
definition:
The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153.


go_id: GO:0031016
term: pancreas development
ontology: BP
definition:
The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.


go_id: GO:0031017
term: exocrine pancreas development
ontology: BP
definition:
The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.


go_id: GO:0031018
term: endocrine pancreas development
ontology: BP
definition:
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.


go_id: GO:0031019
term: mitochondrial mRNA editing complex
ontology: CC
definition:
An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates.


go_id: GO:0031021
term: interphase microtubule organizing center
ontology: CC
definition:
A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus.


go_id: GO:0031022
term: nuclear migration along microfilament
ontology: BP
definition:
The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins.


go_id: GO:0031023
term: microtubule organizing center organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.


go_id: GO:0031024
term: interphase microtubule organizing center assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center.


go_id: GO:0031025
term: equatorial microtubule organizing center disassembly
ontology: BP
definition:
The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis.


go_id: GO:0031027
term: glutamate synthase complex (NADH)
ontology: CC
definition:
A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity.


go_id: GO:0031028
term: septation initiation signaling
ontology: BP
definition:
The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis.


go_id: GO:0031030
term: negative regulation of septation initiation signaling
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling.


go_id: GO:0031031
term: positive regulation of septation initiation signaling
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of septation initiation signaling.


go_id: GO:0031032
term: actomyosin structure organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.


go_id: GO:0031033
term: myosin filament organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules.


go_id: GO:0031038
term: myosin II filament organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules.


go_id: GO:0031039
term: macronucleus
ontology: CC
definition:
A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell.


go_id: GO:0031040
term: micronucleus
ontology: CC
definition:
A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell.


go_id: GO:0031041
term: O-glycan processing, core 5
ontology: BP
definition:
The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-(1->3)-GalNAc.


go_id: GO:0031042
term: O-glycan processing, core 6
ontology: BP
definition:
The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-(1->6)-GalNAc.


go_id: GO:0031043
term: O-glycan processing, core 7
ontology: BP
definition:
The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-(1->6)-GalNAc.


go_id: GO:0031044
term: O-glycan processing, core 8
ontology: BP
definition:
The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-(1->3)-GalNAc.


go_id: GO:0031045
term: dense core granule
ontology: CC
definition:
Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted.


go_id: GO:0031048
term: chromatin silencing by small RNA
ontology: BP
definition:
Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region.


go_id: GO:0031049
term: programmed DNA elimination
ontology: BP
definition:
The DNA metabolic process in which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate.


go_id: GO:0031050
term: dsRNA fragmentation
ontology: BP
definition:
Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function.


go_id: GO:0031051
term: scnRNA production
ontology: BP
definition:
Cleavage of noncoding, double-stranded RNAs transcribed from the micronuclear genome to produce scnRNAs, small RNAs (~28 nucleotides) that direct the deletion of micronuclear-limited sequences from the developing macronuclear genome.


go_id: GO:0031052
term: chromosome breakage
ontology: BP
definition:
Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage.


go_id: GO:0031053
term: primary miRNA processing
ontology: BP
definition:
Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule.


go_id: GO:0031054
term: pre-miRNA processing
ontology: BP
definition:
Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule.


go_id: GO:0031057
term: negative regulation of histone modification
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone.


go_id: GO:0031058
term: positive regulation of histone modification
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone.


go_id: GO:0031060
term: regulation of histone methylation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones.


go_id: GO:0031061
term: negative regulation of histone methylation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones.


go_id: GO:0031062
term: positive regulation of histone methylation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones.


go_id: GO:0031063
term: regulation of histone deacetylation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones.


go_id: GO:0031064
term: negative regulation of histone deacetylation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones.


go_id: GO:0031065
term: positive regulation of histone deacetylation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.


go_id: GO:0031066
term: regulation of histone deacetylation at centromere
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA.


go_id: GO:0031067
term: negative regulation of histone deacetylation at centromere
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA.


go_id: GO:0031068
term: positive regulation of histone deacetylation at centromere
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA.


go_id: GO:0031070
term: intronic snoRNA processing
ontology: BP
definition:
The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA.


go_id: GO:0031071
term: cysteine desulfurase activity
ontology: MF
definition:
Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine.


go_id: GO:0031073
term: cholesterol 26-hydroxylase activity
ontology: MF
definition:
Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol.


go_id: GO:0031076
term: embryonic camera-type eye development
ontology: BP
definition:
The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.


go_id: GO:0031077
term: post-embryonic camera-type eye development
ontology: BP
definition:
The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure.


go_id: GO:0031078
term: histone deacetylase activity (H3-K14 specific)
ontology: MF
definition:
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein.


go_id: GO:0031080
term: nuclear pore outer ring
ontology: CC
definition:
A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).


go_id: GO:0031082
term: BLOC complex
ontology: CC
definition:
Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex.


go_id: GO:0031083
term: BLOC-1 complex
ontology: CC
definition:
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins.


go_id: GO:0031084
term: BLOC-2 complex
ontology: CC
definition:
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru.


go_id: GO:0031085
term: BLOC-3 complex
ontology: CC
definition:
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins.


go_id: GO:0031086
term: nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
ontology: BP
definition:
A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability.


go_id: GO:0031087
term: deadenylation-independent decapping of nuclear-transcribed mRNA
ontology: BP
definition:
Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening.


go_id: GO:0031090
term: organelle membrane
ontology: CC
definition:
A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.


go_id: GO:0031091
term: platelet alpha granule
ontology: CC
definition:
A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).


go_id: GO:0031094
term: platelet dense tubular network
ontology: CC
definition:
A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin.


go_id: GO:0031097
term: medial cortex
ontology: CC
definition:
A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation.


go_id: GO:0031098
term: stress-activated protein kinase signaling cascade
ontology: BP
definition:
A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.


go_id: GO:0031105
term: septin complex
ontology: CC
definition:
A protein complex containing septins.  Typically, these complexes contain multiple septins and are oligomeric.


go_id: GO:0031109
term: microtubule polymerization or depolymerization
ontology: BP
definition:
Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule.


go_id: GO:0031110
term: regulation of microtubule polymerization or depolymerization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.


go_id: GO:0031111
term: negative regulation of microtubule polymerization or depolymerization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.


go_id: GO:0031112
term: positive regulation of microtubule polymerization or depolymerization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization.


go_id: GO:0031115
term: negative regulation of microtubule polymerization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.


go_id: GO:0031116
term: positive regulation of microtubule polymerization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of microtubule polymerization.


go_id: GO:0031117
term: positive regulation of microtubule depolymerization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.


go_id: GO:0031121
term: equatorial microtubule organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell.


go_id: GO:0031122
term: cytoplasmic microtubule organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.


go_id: GO:0031127
term: alpha-(1,2)-fucosyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage.


go_id: GO:0031128
term: developmental induction
ontology: BP
definition:
Signaling at short range between cells or tissues of different ancestry and developmental potential that results in one cell or tissue effecting a developmental change in the other.


go_id: GO:0031129
term: inductive cell-cell signaling
ontology: BP
definition:
Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate.


go_id: GO:0031131
term: reception of an inductive signal
ontology: BP
definition:
The process in which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change.


go_id: GO:0031133
term: regulation of axon diameter
ontology: BP
definition:
Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained.


go_id: GO:0031134
term: sister chromatid biorientation
ontology: BP
definition:
The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles.


go_id: GO:0031140
term: induction of conjugation upon nutrient starvation
ontology: BP
definition:
The process in which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients.


go_id: GO:0031143
term: pseudopodium
ontology: CC
definition:
A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.


go_id: GO:0031145
term: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.


go_id: GO:0031146
term: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


go_id: GO:0031147
term: 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells.


go_id: GO:0031148
term: DIF-1 biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells.


go_id: GO:0031149
term: sorocarp stalk cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0031150
term: sorocarp stalk development
ontology: BP
definition:
The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0031151
term: histone methyltransferase activity (H3-K79 specific)
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group onto lysine at position 79 of the histone H3 protein.


go_id: GO:0031152
term: aggregation involved in sorocarp development
ontology: BP
definition:
The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.


go_id: GO:0031153
term: slug development involved in sorocarp development
ontology: BP
definition:
The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development begins after aggregation and ends before culmination in sorocarp development.


go_id: GO:0031154
term: culmination involved in sorocarp development
ontology: BP
definition:
The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development.


go_id: GO:0031156
term: regulation of sorocarp development
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0031161
term: phosphatidylinositol catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.


go_id: GO:0031165
term: integral component of contractile vacuolar membrane
ontology: CC
definition:
The component of the contractile vacuolar membrane consisting of gene products that have some part that penetrates at least one leaflet of the membrane bilayer. This component includes gene products that are buried in the bilayer with no exposure outside the bilayer.


go_id: GO:0031166
term: integral component of vacuolar membrane
ontology: CC
definition:
The component of the vacuolar membrane consisting of gene products and protein complexes that have some part that penetrates at least one leaflet of the membrane bilayer. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.


go_id: GO:0031168
term: ferrichrome metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine.


go_id: GO:0031169
term: ferrichrome biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine.


go_id: GO:0031170
term: ferricrocin metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3.


go_id: GO:0031171
term: ferricrocin biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3.


go_id: GO:0031173
term: otolith mineralization completed early in development
ontology: BP
definition:
The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear.


go_id: GO:0031174
term: lifelong otolith mineralization
ontology: BP
definition:
The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added.


go_id: GO:0031175
term: neuron projection development
ontology: BP
definition:
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).


go_id: GO:0031177
term: phosphopantetheine binding
ontology: MF
definition:
Interacting selectively and non-covalently with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate).


go_id: GO:0031179
term: peptide modification
ontology: BP
definition:
The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide.


go_id: GO:0031201
term: SNARE complex
ontology: CC
definition:
A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.


go_id: GO:0031203
term: posttranslational protein targeting to membrane, docking
ontology: BP
definition:
The process in which the signal sequence of a translated protein binds to and forms a complex with the Sec complex.


go_id: GO:0031205
term: endoplasmic reticulum Sec complex
ontology: CC
definition:
An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex.


go_id: GO:0031207
term: Sec62/Sec63 complex
ontology: CC
definition:
A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p.


go_id: GO:0031208
term: POZ domain binding
ontology: MF
definition:
Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors.


go_id: GO:0031209
term: SCAR complex
ontology: CC
definition:
A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.


go_id: GO:0031210
term: phosphatidylcholine binding
ontology: MF
definition:
Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline.


go_id: GO:0031211
term: endoplasmic reticulum palmitoyltransferase complex
ontology: CC
definition:
A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue.


go_id: GO:0031213
term: RSF complex
ontology: CC
definition:
An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters).


go_id: GO:0031214
term: biomineral tissue development
ontology: BP
definition:
Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.


go_id: GO:0031217
term: glucan 1,4-beta-glucosidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units.


go_id: GO:0031219
term: levanase activity
ontology: MF
definition:
Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units.


go_id: GO:0031221
term: arabinan metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving arabinan, a polysaccharide composed of arabinose residues.


go_id: GO:0031222
term: arabinan catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of arabinan, a polysaccharide composed of arabinose residues.


go_id: GO:0031224
term: intrinsic component of membrane
ontology: CC
definition:
The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane.


go_id: GO:0031226
term: intrinsic component of plasma membrane
ontology: CC
definition:
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031227
term: intrinsic component of endoplasmic reticulum membrane
ontology: CC
definition:
The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031228
term: intrinsic component of Golgi membrane
ontology: CC
definition:
The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031229
term: intrinsic component of nuclear inner membrane
ontology: CC
definition:
The component of the nuclear inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031230
term: intrinsic component of cell outer membrane
ontology: CC
definition:
The component of the cell outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031231
term: intrinsic component of peroxisomal membrane
ontology: CC
definition:
The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031232
term: extrinsic component of external side of plasma membrane
ontology: CC
definition:
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.


go_id: GO:0031233
term: intrinsic component of external side of plasma membrane
ontology: CC
definition:
The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor.


go_id: GO:0031234
term: extrinsic component of cytoplasmic side of plasma membrane
ontology: CC
definition:
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.


go_id: GO:0031235
term: intrinsic component of the cytoplasmic side of the plasma membrane
ontology: CC
definition:
The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only.


go_id: GO:0031236
term: extrinsic component of periplasmic side of plasma membrane
ontology: CC
definition:
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its periplasmic surface, but not integrated into the hydrophobic region.


go_id: GO:0031237
term: intrinsic component of periplasmic side of plasma membrane
ontology: CC
definition:
The component of a plasma membrane consisting of gene products and protein complexes that penetrate the periplasmic side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor.


go_id: GO:0031242
term: extrinsic component of external side of cell outer membrane
ontology: CC
definition:
The component of a cell outer membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.


go_id: GO:0031243
term: intrinsic component of external side of cell outer membrane
ontology: CC
definition:
The component of the cell outer membrane consisting of the gene products and protein complexes that penetrate the external side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor.


go_id: GO:0031244
term: extrinsic component of cell outer membrane
ontology: CC
definition:
The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0031245
term: extrinsic component of periplasmic side of cell outer membrane
ontology: CC
definition:
The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to periplasmic surface, but not integrated into the hydrophobic region.


go_id: GO:0031246
term: intrinsic component of periplasmic side of cell outer membrane
ontology: CC
definition:
The component of the cell outer membrane consisting of the gene products that that penetrate the preiplasmic side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor.


go_id: GO:0031247
term: actin rod assembly
ontology: BP
definition:
The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules.


go_id: GO:0031250
term: anaerobic ribonucleoside-triphosphate reductase complex
ontology: CC
definition:
An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit.


go_id: GO:0031251
term: PAN complex
ontology: CC
definition:
A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.


go_id: GO:0031261
term: DNA replication preinitiation complex
ontology: CC
definition:
A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.


go_id: GO:0031262
term: Ndc80 complex
ontology: CC
definition:
A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore.


go_id: GO:0031264
term: death-inducing signaling complex
ontology: CC
definition:
A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10.


go_id: GO:0031265
term: CD95 death-inducing signaling complex
ontology: CC
definition:
A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor.


go_id: GO:0031266
term: TRAIL death-inducing signaling complex
ontology: CC
definition:
A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor.


go_id: GO:0031268
term: pseudopodium organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement.


go_id: GO:0031273
term: negative regulation of pseudopodium assembly
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia.


go_id: GO:0031274
term: positive regulation of pseudopodium assembly
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia.


go_id: GO:0031275
term: regulation of lateral pseudopodium assembly
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell.


go_id: GO:0031276
term: negative regulation of lateral pseudopodium assembly
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell.


go_id: GO:0031277
term: positive regulation of lateral pseudopodium assembly
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell.


go_id: GO:0031278
term: alpha-1,2-galactosyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage.


go_id: GO:0031283
term: negative regulation of guanylate cyclase activity
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of guanylate cyclase activity.


go_id: GO:0031284
term: positive regulation of guanylate cyclase activity
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.


go_id: GO:0031285
term: regulation of sorocarp stalk cell differentiation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0031286
term: negative regulation of sorocarp stalk cell differentiation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0031287
term: positive regulation of sorocarp stalk cell differentiation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0031288
term: sorocarp morphogenesis
ontology: BP
definition:
The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0031290
term: retinal ganglion cell axon guidance
ontology: BP
definition:
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.


go_id: GO:0031291
term: Ran protein signal transduction
ontology: BP
definition:
A series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state.


go_id: GO:0031292
term: gene conversion at mating-type locus, DNA double-strand break processing
ontology: BP
definition:
The 5' to 3' exonucleolytic resection of the DNA at the site of the break at the mating-type locus to form a 3' single-strand DNA overhang.


go_id: GO:0031293
term: membrane protein intracellular domain proteolysis
ontology: BP
definition:
The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain.


go_id: GO:0031294
term: lymphocyte costimulation
ontology: BP
definition:
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation.


go_id: GO:0031295
term: T cell costimulation
ontology: BP
definition:
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.


go_id: GO:0031296
term: B cell costimulation
ontology: BP
definition:
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation.


go_id: GO:0031297
term: replication fork processing
ontology: BP
definition:
The process in which a DNA replication fork that has stalled (due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes) is repaired and replication is restarted.


go_id: GO:0031298
term: replication fork protection complex
ontology: CC
definition:
A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.


go_id: GO:0031300
term: intrinsic component of organelle membrane
ontology: CC
definition:
The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031301
term: integral component of organelle membrane
ontology: CC
definition:
The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031302
term: intrinsic component of endosome membrane
ontology: CC
definition:
The component of the endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031303
term: integral component of endosome membrane
ontology: CC
definition:
The component of the endosome membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031304
term: intrinsic component of mitochondrial inner membrane
ontology: CC
definition:
The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031305
term: integral component of mitochondrial inner membrane
ontology: CC
definition:
The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031306
term: intrinsic component of mitochondrial outer membrane
ontology: CC
definition:
The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031307
term: integral component of mitochondrial outer membrane
ontology: CC
definition:
The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031308
term: intrinsic component of nuclear outer membrane
ontology: CC
definition:
The component of the nuclear outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031309
term: integral component of nuclear outer membrane
ontology: CC
definition:
The component of the nuclear outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031310
term: intrinsic component of vacuolar membrane
ontology: CC
definition:
The component of the vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031311
term: intrinsic component of contractile vacuolar membrane
ontology: CC
definition:
The component of the contractile vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031312
term: extrinsic component of organelle membrane
ontology: CC
definition:
The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0031313
term: extrinsic component of endosome membrane
ontology: CC
definition:
The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0031314
term: extrinsic component of mitochondrial inner membrane
ontology: CC
definition:
The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0031315
term: extrinsic component of mitochondrial outer membrane
ontology: CC
definition:
The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0031316
term: extrinsic component of nuclear outer membrane
ontology: CC
definition:
The component of a nuclear outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0031317
term: tripartite ATP-independent periplasmic transporter complex
ontology: CC
definition:
A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients.


go_id: GO:0031318
term: detection of folic acid
ontology: BP
definition:
The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal.


go_id: GO:0031319
term: detection of cAMP
ontology: BP
definition:
The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP.


go_id: GO:0031321
term: ascospore-type prospore assembly
ontology: BP
definition:
During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane.


go_id: GO:0031322
term: ascospore-type prospore-specific spindle pole body remodeling
ontology: BP
definition:
A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP).


go_id: GO:0031323
term: regulation of cellular metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.


go_id: GO:0031324
term: negative regulation of cellular metabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.


go_id: GO:0031325
term: positive regulation of cellular metabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.


go_id: GO:0031326
term: regulation of cellular biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.


go_id: GO:0031327
term: negative regulation of cellular biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.


go_id: GO:0031328
term: positive regulation of cellular biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.


go_id: GO:0031329
term: regulation of cellular catabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.


go_id: GO:0031330
term: negative regulation of cellular catabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.


go_id: GO:0031331
term: positive regulation of cellular catabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.


go_id: GO:0031332
term: RNAi effector complex
ontology: CC
definition:
Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins.


go_id: GO:0031333
term: negative regulation of protein complex assembly
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.


go_id: GO:0031335
term: regulation of sulfur amino acid metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids.


go_id: GO:0031336
term: negative regulation of sulfur amino acid metabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids.


go_id: GO:0031337
term: positive regulation of sulfur amino acid metabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids.


go_id: GO:0031341
term: regulation of cell killing
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism.


go_id: GO:0031344
term: regulation of cell projection organization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.


go_id: GO:0031345
term: negative regulation of cell projection organization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.


go_id: GO:0031346
term: positive regulation of cell projection organization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.


go_id: GO:0031350
term: intrinsic component of plastid membrane
ontology: CC
definition:
The component of the plastid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031351
term: integral component of plastid membrane
ontology: CC
definition:
The component of the plastid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031352
term: intrinsic component of plastid inner membrane
ontology: CC
definition:
The component of the plastid inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031353
term: integral component of plastid inner membrane
ontology: CC
definition:
The component of the plastid inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031354
term: intrinsic component of plastid outer membrane
ontology: CC
definition:
The component of the plastid outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031355
term: integral component of plastid outer membrane
ontology: CC
definition:
The component of the plastid outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031356
term: intrinsic component of chloroplast inner membrane
ontology: CC
definition:
The component of the chloroplast inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031357
term: integral component of chloroplast inner membrane
ontology: CC
definition:
The component of the chloroplast inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031358
term: intrinsic component of chloroplast outer membrane
ontology: CC
definition:
The component of the chloroplast outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031359
term: integral component of chloroplast outer membrane
ontology: CC
definition:
The component of the chloroplast outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031360
term: intrinsic component of thylakoid membrane
ontology: CC
definition:
The component of the thylakoid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031361
term: integral component of thylakoid membrane
ontology: CC
definition:
The component of the thylakoid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031362
term: anchored component of external side of plasma membrane
ontology: CC
definition:
The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.


go_id: GO:0031364
term: N-terminal protein amino acid deamination, from side chain
ontology: BP
definition:
The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein.


go_id: GO:0031369
term: translation initiation factor binding
ontology: MF
definition:
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.


go_id: GO:0031370
term: eukaryotic initiation factor 4G binding
ontology: MF
definition:
Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.


go_id: GO:0031372
term: UBC13-MMS2 complex
ontology: CC
definition:
A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p.


go_id: GO:0031380
term: nuclear RNA-directed RNA polymerase complex
ontology: CC
definition:
A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain.


go_id: GO:0031381
term: viral RNA-directed RNA polymerase complex
ontology: CC
definition:
A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus.


go_id: GO:0031382
term: mating projection assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi.


go_id: GO:0031383
term: regulation of mating projection assembly
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi.


go_id: GO:0031384
term: regulation of initiation of mating projection growth
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi.


go_id: GO:0031385
term: regulation of termination of mating projection growth
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi.


go_id: GO:0031387
term: MPF complex
ontology: CC
definition:
A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC).


go_id: GO:0031389
term: Rad17 RFC-like complex
ontology: CC
definition:
A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.


go_id: GO:0031390
term: Ctf18 RFC-like complex
ontology: CC
definition:
A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p.


go_id: GO:0031391
term: Elg1 RFC-like complex
ontology: CC
definition:
A pentameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.


go_id: GO:0031392
term: regulation of prostaglandin biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


go_id: GO:0031393
term: negative regulation of prostaglandin biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


go_id: GO:0031394
term: positive regulation of prostaglandin biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


go_id: GO:0031395
term: bursicon neuropeptide hormone complex
ontology: CC
definition:
A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits.


go_id: GO:0031396
term: regulation of protein ubiquitination
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein.


go_id: GO:0031397
term: negative regulation of protein ubiquitination
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.


go_id: GO:0031398
term: positive regulation of protein ubiquitination
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.


go_id: GO:0031399
term: regulation of protein modification process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


go_id: GO:0031400
term: negative regulation of protein modification process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


go_id: GO:0031401
term: positive regulation of protein modification process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


go_id: GO:0031406
term: carboxylic acid binding
ontology: MF
definition:
Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).


go_id: GO:0031407
term: oxylipin metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.


go_id: GO:0031408
term: oxylipin biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.


go_id: GO:0031409
term: pigment binding
ontology: MF
definition:
Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin.


go_id: GO:0031411
term: gas vesicle
ontology: CC
definition:
An intracellular non-membrane-bounded organelle; a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content, aquatic microbes are able to perform vertical migrations.


go_id: GO:0031412
term: gas vesicle organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps.


go_id: GO:0031413
term: regulation of buoyancy
ontology: BP
definition:
Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases.


go_id: GO:0031414
term: N-terminal protein acetyltransferase complex
ontology: CC
definition:
A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule.


go_id: GO:0031415
term: NatA complex
ontology: CC
definition:
A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins.


go_id: GO:0031416
term: NatB complex
ontology: CC
definition:
A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p.


go_id: GO:0031417
term: NatC complex
ontology: CC
definition:
A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p.


go_id: GO:0031418
term: L-ascorbic acid binding
ontology: MF
definition:
Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.


go_id: GO:0031419
term: cobalamin binding
ontology: MF
definition:
Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.


go_id: GO:0031420
term: alkali metal ion binding
ontology: MF
definition:
Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen.


go_id: GO:0031421
term: invertasome
ontology: CC
definition:
A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts.


go_id: GO:0031422
term: RecQ helicase-Topo III complex
ontology: CC
definition:
A complex containing a RecQ family helicase and a topoisomerase III homologue; may also include one or more additional proteins; conserved from E. coli to human.


go_id: GO:0031423
term: hexon binding
ontology: MF
definition:
Interacting selectively and non-covalently with a hexon, the major protein component of the icosahedral capsid of an adenovirus.


go_id: GO:0031424
term: keratinization
ontology: BP
definition:
The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.


go_id: GO:0031425
term: chloroplast RNA processing
ontology: BP
definition:
The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules.


go_id: GO:0031426
term: polycistronic mRNA processing
ontology: BP
definition:
The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules.


go_id: GO:0031427
term: response to methotrexate
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.


go_id: GO:0031428
term: box C/D snoRNP complex
ontology: CC
definition:
A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type that can carry out ribose-2'-O-methylation of target RNAs.


go_id: GO:0031430
term: M band
ontology: CC
definition:
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.


go_id: GO:0031431
term: Dbf4-dependent protein kinase complex
ontology: CC
definition:
A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins.


go_id: GO:0031432
term: titin binding
ontology: MF
definition:
Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.


go_id: GO:0031433
term: telethonin binding
ontology: MF
definition:
Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase.


go_id: GO:0031434
term: mitogen-activated protein kinase kinase binding
ontology: MF
definition:
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase.


go_id: GO:0031435
term: mitogen-activated protein kinase kinase kinase binding
ontology: MF
definition:
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.


go_id: GO:0031436
term: BRCA1-BARD1 complex
ontology: CC
definition:
A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage.


go_id: GO:0031437
term: regulation of mRNA cleavage
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of mRNA cleavage, any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.


go_id: GO:0031440
term: regulation of mRNA 3'-end processing
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule.


go_id: GO:0031441
term: negative regulation of mRNA 3'-end processing
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing.


go_id: GO:0031443
term: fast-twitch skeletal muscle fiber contraction
ontology: BP
definition:
A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability.


go_id: GO:0031444
term: slow-twitch skeletal muscle fiber contraction
ontology: BP
definition:
A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue.


go_id: GO:0031446
term: regulation of fast-twitch skeletal muscle fiber contraction
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of fast-twitch skeletal muscle contraction.


go_id: GO:0031447
term: negative regulation of fast-twitch skeletal muscle fiber contraction
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of fast-twitch skeletal muscle contraction.


go_id: GO:0031448
term: positive regulation of fast-twitch skeletal muscle fiber contraction
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction.


go_id: GO:0031449
term: regulation of slow-twitch skeletal muscle fiber contraction
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of slow-twitch skeletal muscle contraction.


go_id: GO:0031450
term: negative regulation of slow-twitch skeletal muscle fiber contraction
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of slow-twitch skeletal muscle contraction.


go_id: GO:0031451
term: positive regulation of slow-twitch skeletal muscle fiber contraction
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of slow-twitch skeletal muscle contraction.


go_id: GO:0031452
term: negative regulation of heterochromatin assembly
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation.


go_id: GO:0031456
term: glycine betaine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of glycine betaine, N-trimethylglycine.


go_id: GO:0031457
term: glycine betaine catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine.


go_id: GO:0031459
term: glycine betaine-transporting ATPase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in).


go_id: GO:0031460
term: glycine betaine transport
ontology: BP
definition:
The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0031461
term: cullin-RING ubiquitin ligase complex
ontology: CC
definition:
Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.


go_id: GO:0031462
term: Cul2-RING ubiquitin ligase complex
ontology: CC
definition:
A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.


go_id: GO:0031463
term: Cul3-RING ubiquitin ligase complex
ontology: CC
definition:
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.


go_id: GO:0031464
term: Cul4A-RING E3 ubiquitin ligase complex
ontology: CC
definition:
A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.


go_id: GO:0031465
term: Cul4B-RING E3 ubiquitin ligase complex
ontology: CC
definition:
A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits.


go_id: GO:0031466
term: Cul5-RING ubiquitin ligase complex
ontology: CC
definition:
A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.


go_id: GO:0031467
term: Cul7-RING ubiquitin ligase complex
ontology: CC
definition:
A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein.


go_id: GO:0031469
term: polyhedral organelle
ontology: CC
definition:
An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.


go_id: GO:0031470
term: carboxysome
ontology: CC
definition:
An organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide including mechanisms for the concentration of carbonate to increase the efficiency of fixation under low-carbon dioxide conditions.


go_id: GO:0031471
term: ethanolamine degradation polyhedral organelle
ontology: CC
definition:
An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase.


go_id: GO:0031472
term: propanediol degradation polyhedral organelle
ontology: CC
definition:
An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase.


go_id: GO:0031473
term: myosin III binding
ontology: MF
definition:
Interacting selectively and non-covalently with a class III myosin; myosin III is monomeric and has an N terminal kinase domain.


go_id: GO:0031474
term: myosin IV complex
ontology: CC
definition:
A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV.


go_id: GO:0031475
term: myosin V complex
ontology: CC
definition:
A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region.


go_id: GO:0031476
term: myosin VI complex
ontology: CC
definition:
A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments.


go_id: GO:0031477
term: myosin VII complex
ontology: CC
definition:
A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain.


