# go_term

go_id: GO:0060995
term: cell-cell signaling involved in kidney development
ontology: BP
definition:
Any process that mediates the transfer of information from one cell to another and contributes to the progression of the kidney over time, from its formation to the mature organ.


go_id: GO:0060996
term: dendritic spine development
ontology: BP
definition:
The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.


go_id: GO:0060997
term: dendritic spine morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.


go_id: GO:0060998
term: regulation of dendritic spine development
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.


go_id: GO:0060999
term: positive regulation of dendritic spine development
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.


go_id: GO:0061000
term: negative regulation of dendritic spine development
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.


go_id: GO:0061001
term: regulation of dendritic spine morphogenesis
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.


go_id: GO:0061002
term: negative regulation of dendritic spine morphogenesis
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.


go_id: GO:0061004
term: pattern specification involved in kidney development
ontology: BP
definition:
Any developmental process that results in the creation of defined areas or spaces within the kidney to which cells respond and eventually are instructed to differentiate.


go_id: GO:0061005
term: cell differentiation involved in kidney development
ontology: BP
definition:
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state.


go_id: GO:0061006
term: regulation of cell proliferation involved in kidney morphogenesis
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney.


go_id: GO:0061007
term: hepaticobiliary system process
ontology: BP
definition:
An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.


go_id: GO:0061008
term: hepaticobiliary system development
ontology: BP
definition:
The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins.


go_id: GO:0061009
term: common bile duct development
ontology: BP
definition:
The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gall bladder. The common bile duct transports bile from the liver and gall bladder to the intestine.


go_id: GO:0061010
term: gall bladder development
ontology: BP
definition:
The progression of the gall bladder over time, from its initial formation to the mature structure. The gall bladder is a cavitated organ that stores bile.


go_id: GO:0061011
term: hepatic duct development
ontology: BP
definition:
The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct.


go_id: GO:0061013
term: regulation of mRNA catabolic process
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.


go_id: GO:0061014
term: positive regulation of mRNA catabolic process
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.


go_id: GO:0061017
term: hepatoblast differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes.


go_id: GO:0061024
term: membrane organization
ontology: BP
definition:
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.


go_id: GO:0061026
term: cardiac muscle tissue regeneration
ontology: BP
definition:
The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.


go_id: GO:0061027
term: umbilical cord development
ontology: BP
definition:
The process whose specific outcome is the development of the umbilical cord, from its formation to the mature structure. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta.


go_id: GO:0061028
term: establishment of endothelial barrier
ontology: BP
definition:
The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.


go_id: GO:0061029
term: eyelid development in camera-type eye
ontology: BP
definition:
The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye.


go_id: GO:0061030
term: epithelial cell differentiation involved in mammary gland alveolus development
ontology: BP
definition:
The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus.


go_id: GO:0061031
term: endodermal digestive tract morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm.


go_id: GO:0061032
term: visceral serous pericardium development
ontology: BP
definition:
The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.


go_id: GO:0061033
term: secretion by lung epithelial cell involved in lung growth
ontology: BP
definition:
The controlled release of liquid by a lung epithelial cell that contributes to an increase in size of the lung as part of its development.


go_id: GO:0061034
term: olfactory bulb mitral cell layer development
ontology: BP
definition:
The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer.


go_id: GO:0061035
term: regulation of cartilage development
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


go_id: GO:0061036
term: positive regulation of cartilage development
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


go_id: GO:0061037
term: negative regulation of cartilage development
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.


go_id: GO:0061041
term: regulation of wound healing
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.


go_id: GO:0061042
term: vascular wound healing
ontology: BP
definition:
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.


go_id: GO:0061043
term: regulation of vascular wound healing
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.


go_id: GO:0061044
term: negative regulation of vascular wound healing
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.


go_id: GO:0061045
term: negative regulation of wound healing
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.


go_id: GO:0061046
term: regulation of branching involved in lung morphogenesis
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.


go_id: GO:0061048
term: negative regulation of branching involved in lung morphogenesis
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.


go_id: GO:0061049
term: cell growth involved in cardiac muscle cell development
ontology: BP
definition:
The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.


go_id: GO:0061050
term: regulation of cell growth involved in cardiac muscle cell development
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.


go_id: GO:0061051
term: positive regulation of cell growth involved in cardiac muscle cell development
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.


go_id: GO:0061052
term: negative regulation of cell growth involved in cardiac muscle cell development
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.


go_id: GO:0061053
term: somite development
ontology: BP
definition:
The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.


go_id: GO:0061054
term: dermatome development
ontology: BP
definition:
The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.


go_id: GO:0061055
term: myotome development
ontology: BP
definition:
The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle.


go_id: GO:0061056
term: sclerotome development
ontology: BP
definition:
The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.


go_id: GO:0061057
term: peptidoglycan recognition protein signaling pathway
ontology: BP
definition:
A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides.


go_id: GO:0061058
term: regulation of peptidoglycan recognition protein signaling pathway
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway.


go_id: GO:0061059
term: positive regulation of peptidoglycan recognition protein signaling pathway
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway.


go_id: GO:0061060
term: negative regulation of peptidoglycan recognition protein signaling pathway
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway.


go_id: GO:0061061
term: muscle structure development
ontology: BP
definition:
The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.


go_id: GO:0061062
term: regulation of nematode larval development
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.


go_id: GO:0061063
term: positive regulation of nematode larval development
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.


go_id: GO:0061064
term: negative regulation of nematode larval development
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.


go_id: GO:0061065
term: regulation of dauer larval development
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.


go_id: GO:0061066
term: positive regulation of dauer larval development
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.


go_id: GO:0061067
term: negative regulation of dauer larval development
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.


go_id: GO:0061068
term: urethra development
ontology: BP
definition:
The progression of the urethra over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body.


go_id: GO:0061069
term: male urethra development
ontology: BP
definition:
The progression of the male urethra over time from its initial formation to the mature structure. The male urethra is a renal system organ that carries urine from the bladder through the penis to outside the body.


go_id: GO:0061070
term: female urethra development
ontology: BP
definition:
The progression of the female urethra over time from its initial formation to the mature structure. The female urethra is a renal system organ that carries urine from the bladder to outside the body, exiting above the vaginal opening.


go_id: GO:0061071
term: urethra epithelium development
ontology: BP
definition:
The progression of the urethra epithelium over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes.


go_id: GO:0061072
term: iris morphogenesis
ontology: BP
definition:
The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina.


go_id: GO:0061073
term: ciliary body morphogenesis
ontology: BP
definition:
The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes.


go_id: GO:0061074
term: regulation of neural retina development
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.


go_id: GO:0061075
term: positive regulation of neural retina development
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.


go_id: GO:0061076
term: negative regulation of neural retina development
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.


go_id: GO:0061077
term: chaperone-mediated protein folding
ontology: BP
definition:
The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.


go_id: GO:0061078
term: positive regulation of prostaglandin secretion involved in immune response
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell and contributes to the immune response.


go_id: GO:0061079
term: left horn of sinus venosus development
ontology: BP
definition:
The progression of the left horn of the sinus venosus from its initial formation to the mature structure.


go_id: GO:0061081
term: positive regulation of myeloid leukocyte cytokine production involved in immune response
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response.


go_id: GO:0061083
term: regulation of protein refolding
ontology: BP
definition:
Any process that regulates the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.


go_id: GO:0061084
term: negative regulation of protein refolding
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.


go_id: GO:0061085
term: regulation of histone H3-K27 methylation
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.


go_id: GO:0061086
term: negative regulation of histone H3-K27 methylation
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.


go_id: GO:0061087
term: positive regulation of histone H3-K27 methylation
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.


go_id: GO:0061088
term: regulation of sequestering of zinc ion
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system.


go_id: GO:0061089
term: negative regulation of sequestering of zinc ion
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system.


go_id: GO:0061090
term: positive regulation of sequestering of zinc ion
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system.


go_id: GO:0061091
term: regulation of phospholipid translocation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.


go_id: GO:0061092
term: positive regulation of phospholipid translocation
ontology: BP
definition:
Any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.


go_id: GO:0061093
term: negative regulation of phospholipid translocation
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.


go_id: GO:0061094
term: regulation of turning behavior involved in mating
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail.


go_id: GO:0061095
term: positive regulation of turning behavior involved in mating
ontology: BP
definition:
Any process that increases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail.


go_id: GO:0061096
term: negative regulation of turning behavior involved in mating
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail.


go_id: GO:0061100
term: lung neuroendocrine cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium.


go_id: GO:0061101
term: neuroendocrine cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance.


go_id: GO:0061102
term: stomach neuroendocrine cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium.


go_id: GO:0061103
term: carotid body glomus cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia.


go_id: GO:0061104
term: adrenal chromaffin cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles.


go_id: GO:0061105
term: regulation of stomach neuroendocrine cell differentiation
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.


go_id: GO:0061106
term: negative regulation of stomach neuroendocrine cell differentiation
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.


go_id: GO:0061107
term: seminal vesicle development
ontology: BP
definition:
The progression of the seminal vesicle over time, from its formation to the mature structure. The seminal vesicle is a gland that contributes to the production of semen.


go_id: GO:0061108
term: seminal vesicle epithelium development
ontology: BP
definition:
The progression of the seminal vesicle epithelium over time, from its formation to the mature structure.


go_id: GO:0061109
term: dense core granule organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells.


go_id: GO:0061110
term: dense core granule biogenesis
ontology: BP
definition:
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a dense core granule. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the dense core granule.


go_id: GO:0061111
term: epithelial-mesenchymal cell signaling involved in lung development
ontology: BP
definition:
Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ.


go_id: GO:0061112
term: negative regulation of bud outgrowth involved in lung branching
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of bud outgrowth involved in lung branching.


go_id: GO:0061113
term: pancreas morphogenesis
ontology: BP
definition:
Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized.


go_id: GO:0061115
term: lung proximal/distal axis specification
ontology: BP
definition:
The establishment, maintenance and elaboration of the proximal/distal axis of the lung. The proximal/distal axis of the lung is defined by a line that runs from the trachea to the alveoli.


go_id: GO:0061116
term: ductus venosus closure
ontology: BP
definition:
The morphogenesis process in which the ductus venosus changes to no longer permit blood flow after birth.


go_id: GO:0061117
term: negative regulation of heart growth
ontology: BP
definition:
Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.


go_id: GO:0061118
term: regulation of positive chemotaxis to cAMP
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP.


go_id: GO:0061119
term: regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions.


go_id: GO:0061120
term: regulation of positive chemotaxis to cAMP by DIF-1
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone.


go_id: GO:0061121
term: regulation of positive chemotaxis to cAMP by DIF-2
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone.


go_id: GO:0061122
term: positive regulation of positive chemotaxis to cAMP
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP.


go_id: GO:0061123
term: negative regulation of positive chemotaxis to cAMP
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP.


go_id: GO:0061124
term: positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions.


go_id: GO:0061125
term: negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions.


go_id: GO:0061126
term: positive regulation of positive chemotaxis to cAMP by DIF-1
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone.


go_id: GO:0061127
term: negative regulation of positive chemotaxis to cAMP by DIF-1
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone.


go_id: GO:0061128
term: positive regulation of chemotaxis to cAMP by DIF-2
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone.


go_id: GO:0061129
term: negative regulation of positive chemotaxis to cAMP by DIF-2
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone.


go_id: GO:0061131
term: pancreas field specification
ontology: BP
definition:
The process in which a specific region of the gut is delineated into the area in which the pancreas will develop.


go_id: GO:0061132
term: pancreas induction
ontology: BP
definition:
The close range interaction of two or more cells or tissues that causes the cells of the gut to change their fates and specify the development of the pancreas.


go_id: GO:0061137
term: bud dilation
ontology: BP
definition:
The process in which a branch bud increases radially. A branch bud is the initial area of outgrowth in the formation of a new branch.


go_id: GO:0061138
term: morphogenesis of a branching epithelium
ontology: BP
definition:
The process in which the anatomical structures of a branched epithelium are generated and organized.


go_id: GO:0061139
term: bud field specification
ontology: BP
definition:
The regionalization process in which the identity of a bud primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


go_id: GO:0061140
term: lung secretory cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part.


go_id: GO:0061141
term: lung ciliated cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains a motile cilium for moving substances released from lung secretory cells.


go_id: GO:0061142
term: mesothelial-mesenchymal cell signaling involved in early lung development
ontology: BP
definition:
Any process that mediates the transfer of information from a mesothelial cell to an epithelial cell and contributes to the development of the lung.


go_id: GO:0061143
term: alveolar primary septum development
ontology: BP
definition:
The progression of a primary alveolar septum over time, from its formation to the mature structure. A primary alveolar septum is a specialized epithelium that surrounds the saccule as it forms.


go_id: GO:0061144
term: alveolar secondary septum development
ontology: BP
definition:
The progression of a secondary alveolar septum over time, from its formation to the mature structure. A secondary alveolar septum is a specialized epithelium that subdivides the initial saccule.


go_id: GO:0061145
term: lung smooth muscle development
ontology: BP
definition:
The process whose specific outcome is the progression of smooth muscle in the lung over time, from its formation to the mature structure.


go_id: GO:0061146
term: Peyer's patch morphogenesis
ontology: BP
definition:
The process in which a Peyer's patch is generated and organized. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes.


go_id: GO:0061147
term: endocardial endothelium development
ontology: BP
definition:
The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.


go_id: GO:0061148
term: extracellular matrix organization involved in endocardium development
ontology: BP
definition:
A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.


go_id: GO:0061149
term: BMP signaling pathway involved in ureter morphogenesis
ontology: BP
definition:
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder.


go_id: GO:0061150
term: renal system segmentation
ontology: BP
definition:
The regionalization process that divides an the renal system into a series of segments along its proximal/distal axis.


go_id: GO:0061151
term: BMP signaling pathway involved in renal system segmentation
ontology: BP
definition:
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the segmentation of the renal system.


go_id: GO:0061152
term: trachea submucosa development
ontology: BP
definition:
The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea.


go_id: GO:0061153
term: trachea gland development
ontology: BP
definition:
The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection.


go_id: GO:0061154
term: endothelial tube morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.


go_id: GO:0061155
term: pulmonary artery endothelial tube morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery.


go_id: GO:0061156
term: pulmonary artery morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs.


go_id: GO:0061157
term: mRNA destabilization
ontology: BP
definition:
Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.


go_id: GO:0061158
term: 3'-UTR-mediated mRNA destabilization
ontology: BP
definition:
An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.


go_id: GO:0061159
term: establishment of bipolar cell polarity involved in cell morphogenesis
ontology: BP
definition:
The specification and formation of bipolar intracellular organization or cell growth patterns that contribute to cell morphogenesis. Bipolar organization is the organization that is a mirror image along an axis from a plane.


go_id: GO:0061160
term: regulation of establishment of bipolar cell polarity regulating cell shape
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity that contributes to the shape of a cell.


go_id: GO:0061161
term: positive regulation of establishment of bipolar cell polarity regulating cell shape
ontology: BP
definition:
Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity that regulates the shape of a cell.


go_id: GO:0061162
term: establishment of monopolar cell polarity
ontology: BP
definition:
The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis.


go_id: GO:0061163
term: endoplasmic reticulum polarization
ontology: BP
definition:
The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell.


go_id: GO:0061164
term: transitional endoplasmic reticulum polarization at cell division site
ontology: BP
definition:
The endoplasmic reticulum polarization process that results in the structure being polarized at the site of future cell division.


go_id: GO:0061165
ontology: BP
term:
endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site

definition:
The process in which endoplasmic reticulum is transiently localized to the site where a cell will divide.


go_id: GO:0061166
ontology: BP
definition: The directed movement of the endoplasmic reticulum to the site where a cell will divide.
term:
establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site


go_id: GO:0061167
ontology: BP
term:
maintenance of endoplasmic reticulum location involved in endoplasmic reticulum polarization at cell division site

definition:
The process in which the endoplasmic reticulum is maintained at the site of cell division and is prevented from moving elsewhere.


go_id: GO:0061168
term: regulation of hair follicle placode formation
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud.


go_id: GO:0061169
term: positive regulation of hair placode formation
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud.


go_id: GO:0061170
term: negative regulation of hair follicle placode formation
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud.


go_id: GO:0061171
term: establishment of bipolar cell polarity
ontology: BP
definition:
The specification and formation of bipolar intracellular organization or cell growth patterns. Bipolar organization is the organization that is a mirror image along an axis from a plane.


go_id: GO:0061172
term: regulation of establishment of bipolar cell polarity
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane.


go_id: GO:0061173
term: positive regulation of establishment of bipolar cell polarity
ontology: BP
definition:
Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity.


go_id: GO:0061174
term: type I terminal bouton
ontology: CC
definition:
Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.


go_id: GO:0061175
term: type II terminal bouton
ontology: CC
definition:
Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.


go_id: GO:0061176
term: type Ib terminal bouton
ontology: CC
definition:
Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons.


go_id: GO:0061177
term: type Is terminal bouton
ontology: CC
definition:
Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons.


go_id: GO:0061178
term: regulation of insulin secretion involved in cellular response to glucose stimulus
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.


go_id: GO:0061179
term: negative regulation of insulin secretion involved in cellular response to glucose stimulus
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.


go_id: GO:0061180
term: mammary gland epithelium development
ontology: BP
definition:
The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.


go_id: GO:0061181
term: regulation of chondrocyte development
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.


go_id: GO:0061182
term: negative regulation of chondrocyte development
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.


go_id: GO:0061183
term: regulation of dermatome development
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.


go_id: GO:0061184
term: positive regulation of dermatome development
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.


go_id: GO:0061185
term: negative regulation of dermatome development
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.


go_id: GO:0061186
term: negative regulation of chromatin silencing at silent mating-type cassette
ontology: BP
definition:
Any process that decreases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin.


go_id: GO:0061187
term: regulation of chromatin silencing at rDNA
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin.


go_id: GO:0061188
term: negative regulation of chromatin silencing at rDNA
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin.


go_id: GO:0061189
term: positive regulation of sclerotome development
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.


go_id: GO:0061190
term: regulation of sclerotome development
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.


go_id: GO:0061191
term: positive regulation of vacuole fusion, non-autophagic
ontology: BP
definition:
Any process that increases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole.


go_id: GO:0061192
term: negative regulation of vacuole fusion, non-autophagic
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole.


go_id: GO:0061193
term: taste bud development
ontology: BP
definition:
The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors.


go_id: GO:0061194
term: taste bud morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the taste bud are generated and organized. The taste bud is a specialized area of the tongue that contains taste receptors.


go_id: GO:0061195
term: taste bud formation
ontology: BP
definition:
The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors.


go_id: GO:0061196
term: fungiform papilla development
ontology: BP
definition:
The progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue.


go_id: GO:0061197
term: fungiform papilla morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the fungiform papilla are generated and organized. The fungiform papilla is a mushroom-shaped papilla of the tongue.


go_id: GO:0061198
term: fungiform papilla formation
ontology: BP
definition:
The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue.


go_id: GO:0061199
term: striated muscle contraction involved in embryonic body morphogenesis
ontology: BP
definition:
The process in which force is generated within striated embryonic muscle tissue, resulting in a contraction of the muscle that contributes to the formation of an embryo's characteristic body morphology.


go_id: GO:0061200
term: clathrin-sculpted gamma-aminobutyric acid transport vesicle
ontology: CC
definition:
A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing gamma-aminobutyric acid transport vesicle.


go_id: GO:0061201
term: clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen
ontology: CC
definition:
The volume enclosed by the membrane of the clathrin-sculpted gamma-aminobutyric acid transport vesicle.


go_id: GO:0061203
term: striated muscle paramyosin thick filament assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of proteins to form the paramyosin-based thick filaments of myofibrils in striated muscle.


go_id: GO:0061205
term: paramesonephric duct development
ontology: BP
definition:
The process whose specific outcome is the progression of the paramesonephric duct over time, from its formation to the mature structure. Mullerian ducts (or paramesonephric ducts) are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin.


go_id: GO:0061207
term: mesonephric juxtaglomerulus cell differentiation
ontology: BP
definition:
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the mesonephros as it progresses from its formation to the mature state.


go_id: GO:0061208
term: cell differentiation involved in mesonephros development
ontology: BP
definition:
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephros as it progresses from its formation to the mature state.


go_id: GO:0061209
term: cell proliferation involved in mesonephros development
ontology: BP
definition:
The multiplication or reproduction of cells, resulting in the expansion of the population in the mesonephros.


go_id: GO:0061210
term: cell-cell signaling involved in mesonephros development
ontology: BP
definition:
Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mesonephros over time, from its formation to the mature organ.


go_id: GO:0061211
term: mesonephric collecting duct development
ontology: BP
definition:
The process whose specific outcome is the progression of a collecting duct in the mesonephros over time, from its formation to the mature structure. The collecting duct regulates water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder.


go_id: GO:0061212
term: mesonephric juxtaglomerular apparatus development
ontology: BP
definition:
The process whose specific outcome is the progression of the juxtaglomerular apparatus in the mesonephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate.


go_id: GO:0061213
term: positive regulation of mesonephros development
ontology: BP
definition:
Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


go_id: GO:0061214
term: mesonephric smooth muscle tissue development
ontology: BP
definition:
The process whose specific outcome is the progression of smooth muscle in the mesonephros over time, from its formation to the mature structure.


go_id: GO:0061215
term: mesonephric nephron development
ontology: BP
definition:
The process whose specific outcome is the progression of a nephron in the mesonephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney.


go_id: GO:0061216
term: regulation of transcription from RNA polymerase II promoter involved in mesonephros development
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the mesonephros progressing from its initial formation to the mature state.


go_id: GO:0061217
term: regulation of mesonephros development
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.


go_id: GO:0061218
term: negative regulation of mesonephros development
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


go_id: GO:0061219
term: mesonephric mesenchyme development
ontology: BP
definition:
The biological process whose specific outcome is the progression of a mesonephric mesenchyme from an initial condition to its mature state. This process begins with the formation of mesonephric mesenchyme and ends with the mature structure. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros.


go_id: GO:0061220
term: mesonephric macula densa development
ontology: BP
definition:
The process whose specific outcome is the progression of the mesonephric macula densa over time, from its formation to the mature structure. The mesonephric macula densa is an area of specialized cells in the distal tubule of the mesonephros that makes contact with the vascular pole of the glomerulus.


go_id: GO:0061221
term: mesonephric mesenchyme morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of a mesonephric mesenchymal tissue are generated and organized. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros.


go_id: GO:0061222
term: mesonephric mesenchymal cell proliferation involved in mesonephros development
ontology: BP
definition:
The multiplication or reproduction of cells, resulting in the expansion of a mesonephric mesenchymal cell population.


go_id: GO:0061223
term: mesonephric mesenchymal cell differentiation
ontology: BP
definition:
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the mesonephros as it progresses from its formation to the mature state.


go_id: GO:0061224
term: mesonephric glomerulus development
ontology: BP
definition:
The progression of the mesonephric glomerulus over time from its initial formation until its mature state. The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros.


go_id: GO:0061225
term: mesonephric extraglomerular mesangial cell proliferation involved in mesonephros development
ontology: BP
definition:
The multiplication or reproduction of extraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa.


go_id: GO:0061226
term: proximal/distal pattern formation involved in mesonephric nephron development
ontology: BP
definition:
The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the mesonephros. The proximal/distal axis is defined by a line that runs from the glomerulus (proximal end) outward toward the mesonephric duct (distal end).


go_id: GO:0061227
term: pattern specification involved in mesonephros development
ontology: BP
definition:
Any developmental process that results in the creation of defined areas or spaces within the mesonephros to which cells respond and eventually are instructed to differentiate.


go_id: GO:0061228
term: mesonephric nephron morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the mesonephric nephron are generated and organized. A mesonephric nephron is the functional unit of the mesonephros.


go_id: GO:0061229
term: mesonephric juxtaglomerulus cell development
ontology: BP
definition:
The process whose specific outcome is the progression of a mesonephric juxtaglomerulus cell over time, from its formation to the mature structure.


go_id: GO:0061230
term: mesonephric juxtaglomerulus cell fate commitment
ontology: BP
definition:
The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric juxtaglomerulus cell.


go_id: GO:0061231
term: mesonephric glomerulus vasculature development
ontology: BP
definition:
The biological process whose specific outcome is the progression of a mesonephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the mesonephric glomerulus vasculature and ends with the mature structure. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus.


go_id: GO:0061232
term: mesonephric glomerular epithelium development
ontology: BP
definition:
The process whose specific outcome is the progression of the mesonephric glomerular epithelium over time, from its formation to the mature structure. The mesonephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the mesonephros. The mesonephric glomerular epithelium consists of both parietal and visceral epithelium. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells in the mesonephros.


go_id: GO:0061233
term: mesonephric glomerular basement membrane development
ontology: BP
definition:
The process whose specific outcome is the progression of the mesonephric glomerular basement membrane over time, from its formation to the mature structure. The mesonephric glomerular basement membrane is the basal laminal portion of the mesonephric glomerulus which performs the actual filtration.


go_id: GO:0061234
term: mesonephric glomerulus morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the mesonephric glomerulus are generated and organized. The mesonephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate mesonephros.


go_id: GO:0061235
term: mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis
ontology: BP
definition:
The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.


go_id: GO:0061236
term: mesonephric comma-shaped body morphogenesis
ontology: BP
definition:
The process in which the mesonephric comma-shaped body is generated and organized. The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros.


go_id: GO:0061237
term: convergent extension involved in mesonephric nephron morphogenesis
ontology: BP
definition:
The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the mesonephros.


go_id: GO:0061238
term: establishment of planar polarity involved in mesonephric nephron morphogenesis
ontology: BP
definition:
Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the mesonephros.


go_id: GO:0061239
term: mesenchymal stem cell differentiation involved in mesonephric nephron morphogenesis
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.


go_id: GO:0061240
term: mesonephric nephron tubule morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of a mesonephric nephron tubule are generated and organized. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros.


go_id: GO:0061241
term: mesonephric nephron epithelium development
ontology: BP
definition:
The process whose specific outcome is the progression of the mesonephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros.


go_id: GO:0061242
term: mesonephric nephron tubule development
ontology: BP
definition:
The progression of a mesonephric nephron tubule over time, from its initial formation to the mature structure. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros.


go_id: GO:0061243
term: mesonephric renal vesicle morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the mesonephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells.


go_id: GO:0061244
term: mesonephric S-shaped body morphogenesis
ontology: BP
definition:
The process in which the mesonephric S-shaped body is generated and organized. The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros.


go_id: GO:0061245
term: establishment or maintenance of bipolar cell polarity
ontology: BP
definition:
Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns.


go_id: GO:0061246
term: establishment or maintenance of bipolar cell polarity regulating cell shape
ontology: BP
definition:
Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns that regulates the shaping of a cell.


go_id: GO:0061247
term: mesonephric glomerular mesangium development
ontology: BP
definition:
The process whose specific outcome is the progression of the mesonephric glomerular mesangium over time, from its formation to the mature structure. The mesonephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the mesonephros, which helps to support the capillary loops in a renal glomerulus.


go_id: GO:0061248
term: mesonephric glomerulus vasculature morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the mesonephric glomerulus vasculature are generated and organized. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus.


go_id: GO:0061249
term: mesonephric glomerular capillary formation
ontology: BP
definition:
The process that gives rise to a mesonephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts.


go_id: GO:0061250
term: mesonephric glomerular epithelial cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells.


go_id: GO:0061251
term: mesonephric glomerular epithelial cell development
ontology: BP
definition:
The process whose specific outcome is the progression of a mesonephric glomerular epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells.


go_id: GO:0061252
term: mesonephric glomerular epithelial cell fate commitment
ontology: BP
definition:
The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells.


go_id: GO:0061253
term: mesonephric glomerular parietal epithelial cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport.


go_id: GO:0061254
term: mesonephric glomerular parietal epithelial cell development
ontology: BP
definition:
The process whose specific outcome is the progression of a mesonephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport.


go_id: GO:0061255
term: mesonephric glomerular parietal epithelial cell fate commitment
ontology: BP
definition:
The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes.


go_id: GO:0061256
term: mesonephric glomerular visceral epithelial cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells in the mesonephros.


go_id: GO:0061257
term: mesonephric glomerular visceral epithelial cell development
ontology: BP
definition:
The process whose specific outcome is the progression of a mesonephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells in the mesonephros.


go_id: GO:0061258
term: mesonephric glomerular visceral epithelial cell fate commitment
ontology: BP
definition:
The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells in the mesonephros.


go_id: GO:0061259
term: mesonephric glomerular mesangial cell differentiation
ontology: BP
definition:
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the mesonephros as it progresses from its formation to the mature state.


go_id: GO:0061260
term: mesonephric mesangial cell differentiation
ontology: BP
definition:
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the mesonephros as it progresses from its formation to the mature state.


go_id: GO:0061261
term: mesenchymal to epithelial transition involved in mesonephros morphogenesis
ontology: BP
definition:
A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephros.


go_id: GO:0061263
term: mesonephric glomerular mesangial cell development
ontology: BP
definition:
The process whose specific outcome is the progression of a glomerular mesangial cell in the mesonephros over time, from its formation to the mature structure.


go_id: GO:0061264
term: mesonephric glomerular mesangial cell fate commitment
ontology: BP
definition:
The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular mesangial cell.


go_id: GO:0061265
term: mesonephric nephron tubule epithelial cell differentiation
ontology: BP
definition:
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephric nephron tubule as it progresses from its formation to the mature state.


go_id: GO:0061266
term: mesonephric interstitial fibroblast differentiation
ontology: BP
definition:
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the mesonephros as it progresses from its formation to the mature state.


go_id: GO:0061267
term: mesonephric interstitial fibroblast development
ontology: BP
definition:
The process whose specific outcome is the progression of a mesonephric interstitial fibroblast over time, from its formation to the mature structure.


go_id: GO:0061268
term: mesonephric interstitial fibroblast fate commitment
ontology: BP
definition:
The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric interstitial fibroblast.


go_id: GO:0061269
term: mesonephric glomerular mesangial cell proliferation involved in mesonephros development
ontology: BP
definition:
The multiplication or reproduction of glomerular mesangial cells in the mesonephros, resulting in the expansion of the population.


go_id: GO:0061270
term: mesonephric intraglomerular mesangial cell proliferation
ontology: BP
definition:
The multiplication or reproduction of intraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis.


go_id: GO:0061271
term: mesenchymal to epithelial transition involved in mesonephric renal vesicle formation
ontology: BP
definition:
A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephric renal vesicle.


go_id: GO:0061272
term: mesonephric connecting tubule development
ontology: BP
definition:
The process whose specific outcome is the progression of the mesonephric connecting tubule over time, from its formation to the mature structure. The mesonephric connecting tubule is a tubular segment of the mesonephric nephron; it connects the distal tubule to the collecting duct in the mesonephros.


go_id: GO:0061273
term: mesonephric distal tubule morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of a mesonephric distal tubule are generated and organized. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the macula densa and extends to the mesonephric connecting tubule.


go_id: GO:0061274
term: mesonephric distal tubule development
ontology: BP
definition:
The process whose specific outcome is the progression of the mesonephric distal tubule over time, from its formation to the mature structure. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the terminal segment of the proximal tubule and ends at the mesonephric connecting tubule.


go_id: GO:0061275
term: mesonephric proximal tubule development
ontology: BP
definition:
The progression of the mesonephric proximal tubule over time, from its formation to the mature structure. The mesonephric proximal tubule extends from the capsule to the distal tubule.


go_id: GO:0061276
term: mesonephric proximal tubule morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of a mesonephric proximal tubule are generated and organized. The mesonephric proximal tubule extends from the capsule to the distal tubule.


go_id: GO:0061277
term: mesonephric nephron tubule formation
ontology: BP
definition:
The developmental process pertaining to the initial formation of a mesonephric nephron tubule from unspecified parts. A mesonephric nephron tubule is an epithelial tube that is part of a nephron in the mesonephros.


go_id: GO:0061278
term: epithelial cell migration involved in mesonephric nephron tubule morphogenesis
ontology: BP
definition:
The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric nephron tubule morphogenesis.


go_id: GO:0061279
term: epithelial cell migration involved in mesonephric distal tubule morphogenesis
ontology: BP
definition:
The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric distal tubule morphogenesis.


go_id: GO:0061280
term: epithelial cell migration involved in mesonephric proximal tubule morphogenesis
ontology: BP
definition:
The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric proximal tubule morphogenesis.


go_id: GO:0061282
term: specification of mesonephric nephron tubule identity
ontology: BP
definition:
The process in which the tubules arranged along the proximal/distal axis of the mesonephric nephron acquire their identity.


go_id: GO:0061285
term: mesonephric capsule development
ontology: BP
definition:
The progression of the mesonephric capsule over time, from its formation to the mature structure. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue.


go_id: GO:0061286
term: mesonephric capsule morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the mesonephric capsule are generated and organized. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage.


go_id: GO:0061287
term: mesonephric capsule formation
ontology: BP
definition:
The developmental process pertaining to the initial formation of a mesonephric capsule from unspecified parts. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage.


go_id: GO:0061288
term: mesonephric capsule specification
ontology: BP
definition:
The regionalization process in which the identity of the mesonephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


go_id: GO:0061289
term: Wnt signaling pathway involved in kidney development
ontology: BP
definition:
The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the kidney over time.


go_id: GO:0061290
term: canonical Wnt signaling pathway involved in metanephric kidney development
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the metanephric kidney over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.


go_id: GO:0061291
term: canonical Wnt signaling pathway involved in ureteric bud branching
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the branching of the ureteric bud. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.


go_id: GO:0061292
term: canonical Wnt signaling pathway involved in mesonephros development
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the mesonephros over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.


go_id: GO:0061293
term: canonical Wnt signaling pathway involved in mesonephric nephron development
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the mesonephric nephron over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.


go_id: GO:0061294
term: mesonephric renal vesicle induction
ontology: BP
definition:
Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the mesonephric renal vesicle.


go_id: GO:0061295
term: regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
ontology: BP
definition:
Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros.


go_id: GO:0061296
ontology: BP
term:
negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis

definition:
Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros.


go_id: GO:0061297
ontology: BP
term:
positive regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis

definition:
Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros.


go_id: GO:0061298
term: retina vasculature development in camera-type eye
ontology: BP
definition:
The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.


go_id: GO:0061300
term: cerebellum vasculature development
ontology: BP
definition:
The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure.


go_id: GO:0061303
term: cornea development in camera-type eye
ontology: BP
definition:
The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye.


go_id: GO:0061304
term: retinal blood vessel morphogenesis
ontology: BP
definition:
The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure.


go_id: GO:0061305
term: maintenance of bipolar cell polarity regulating cell shape
ontology: BP
definition:
The maintenance of established bipolar anisotropic intracellular organization or cell growth patterns that results in the shaping of a cell.


go_id: GO:0061306
term: DNA strand renaturation involved in double-strand break repair
ontology: BP
definition:
The identification and annealing of complementary base pairs in single-strand DNA that contributes to double-strand break repair.


go_id: GO:0061307
term: cardiac neural crest cell differentiation involved in heart development
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches.


go_id: GO:0061308
term: cardiac neural crest cell development involved in heart development
ontology: BP
definition:
The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart.


go_id: GO:0061309
term: cardiac neural crest cell development involved in outflow tract morphogenesis
ontology: BP
definition:
The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract.


go_id: GO:0061310
ontology: BP
term:
canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development

definition:
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in cardiac neural crest cell differentiation.


go_id: GO:0061311
term: cell surface receptor signaling pathway involved in heart development
ontology: BP
definition:
Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time.


go_id: GO:0061312
term: BMP signaling pathway involved in heart development
ontology: BP
definition:
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time.


go_id: GO:0061313
term: fibroblast growth factor receptor signaling pathway involved in heart development
ontology: BP
definition:
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands and contributing to the progression of the heart over time.


go_id: GO:0061314
term: Notch signaling involved in heart development
ontology: BP
definition:
The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time.


go_id: GO:0061315
ontology: BP
term:
canonical Wnt signaling pathway involved in positive regulation of cardiac muscle cell proliferation

definition:
The canonical Wnt signaling pathway that contributes to an expansion of the population of cardiac muscle cells.


go_id: GO:0061316
term: canonical Wnt signaling pathway involved in heart development
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.


go_id: GO:0061317
term: canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin and contributing to cardiac muscle cell fate commitment. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.


go_id: GO:0061318
term: renal filtration cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a renal filtration cell. Renal filtration cells are specialized cells of the renal system that filter fluids by charge, size or both. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


go_id: GO:0061319
term: nephrocyte differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a nephrocyte. A nephrocyte is an insect renal cell that filters hemolymph. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


go_id: GO:0061320
term: pericardial nephrocyte differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


go_id: GO:0061321
term: garland nephrocyte differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


go_id: GO:0061322
term: disseminated nephrocyte differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a disseminated nephrocyte. A disseminated nephrocyte is an insect renal cell that filters hemolymph and is found at scattered locations in the fat body or other tissues. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.


go_id: GO:0061323
term: cell proliferation involved in heart morphogenesis
ontology: BP
definition:
The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart.


go_id: GO:0061324
ontology: BP
term:
canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation

definition:
The canonical Wnt signaling pathway that contributes to the modulation of the expansion of a population of cardiac outflow tract cells.


go_id: GO:0061325
term: cell proliferation involved in outflow tract morphogenesis
ontology: BP
definition:
The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract.


go_id: GO:0061326
term: renal tubule development
ontology: BP
definition:
The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.


go_id: GO:0061327
term: anterior Malpighian tubule development
ontology: BP
definition:
The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut.


go_id: GO:0061328
term: posterior Malpighian tubule development
ontology: BP
definition:
The process whose specific outcome is the progression of the posterior Malpighian tubule over time, from its formation to the mature structure. The pair of posterior tubules arise from a ventrolateral region of the embryonic hindgut and project backwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut.


go_id: GO:0061329
term: Malpighian tubule principal cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule principal cell. A Malpighian tubule principal cell is an epithelial secretory cell that transports cations into the lumen of the tubule.


go_id: GO:0061330
term: Malpighian tubule stellate cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium.


go_id: GO:0061331
term: epithelial cell proliferation involved in Malpighian tubule morphogenesis
ontology: BP
definition:
The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule.


go_id: GO:0061332
term: Malpighian tubule bud morphogenesis
ontology: BP
definition:
The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position.


go_id: GO:0061333
term: renal tubule morphogenesis
ontology: BP
definition:
The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.


go_id: GO:0061334
term: cell rearrangement involved in Malpighian tubule morphogenesis
ontology: BP
definition:
The movement of an epithelial cell with respect to other epithelial cells that contributes to the shaping of the Malpighian tubule.


go_id: GO:0061335
term: cell growth involved in Malpighian tubule morphogenesis
ontology: BP
definition:
The growth of an epithelial cell dependent on cycles of endoreplication, where growth contributes to the shaping of the Malpighian tubule.


go_id: GO:0061336
term: cell morphogenesis involved in Malpighian tubule morphogenesis
ontology: BP
definition:
The shape change of an epithelial cell from a columnar to squamous cell morphology that contributes to the shaping of the Malpighian tubule.


go_id: GO:0061337
term: cardiac conduction
ontology: BP
definition:
Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.


go_id: GO:0061339
term: establishment or maintenance of monopolar cell polarity
ontology: BP
definition:
Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis.


go_id: GO:0061340
term: establishment or maintenance of monopolar cell polarity regulating cell shape
ontology: BP
definition:
Any cellular process that results in the specification, formation or maintenance of a monopolar intracellular organization or cell growth patterns that regulate the shape of a cell.


go_id: GO:0061341
term: non-canonical Wnt signaling pathway involved in heart development
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to the progression of the heart over time.


go_id: GO:0061342
term: regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signaling pathway
ontology: BP
definition:
Any process that decreased the extent of cell adhesion that contributes to the shaping of the heart.


go_id: GO:0061343
term: cell adhesion involved in heart morphogenesis
ontology: BP
definition:
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart.


go_id: GO:0061345
term: planar cell polarity pathway involved in cardiac muscle cell fate commitment
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to a cardioblast being committed to a cardiac muscle cell fate.


go_id: GO:0061346
term: planar cell polarity pathway involved in heart morphogenesis
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the heart.


go_id: GO:0061347
term: planar cell polarity pathway involved in outflow tract morphogenesis
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the outflow tract.


go_id: GO:0061348
term: planar cell polarity pathway involved in ventricular septum morphogenesis
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the ventricular septum.


go_id: GO:0061349
term: planar cell polarity pathway involved in cardiac right atrium morphogenesis
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac right atrium.


go_id: GO:0061350
term: planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac muscle tissue.


go_id: GO:0061351
term: neural precursor cell proliferation
ontology: BP
definition:
The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.


go_id: GO:0061352
term: cell chemotaxis involved in Malpighian tubule morphogenesis
ontology: BP
definition:
The directed movement of the outgrowing Malpighian tubule guided by specific chemical cues/signals. Movement may be towards a guidance cue (positive chemotaxis) or away from it (negative chemotaxis). Guidance contributes to the final positioning of the tubule.


go_id: GO:0061353
term: BMP signaling pathway involved in Malpighian tubule cell chemotaxis
ontology: BP
definition:
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the directed movement of a Malpighian tubule cell toward a stimulus, thereby contributing to the shaping of the tubule.


go_id: GO:0061354
term: planar cell polarity pathway involved in pericardium morphogenesis
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the pericardium.


go_id: GO:0061356
term: regulation of Wnt protein secretion
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the controlled release of a Wnt protein from a cell.


go_id: GO:0061357
term: positive regulation of Wnt protein secretion
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell.


go_id: GO:0061358
term: negative regulation of Wnt protein secretion
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a Wnt protein from a cell.


go_id: GO:0061359
term: regulation of Wnt signaling pathway by Wnt protein secretion
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the activity of the Wnt signaling pathway by the controlled release of a Wnt protein from a cell.


go_id: GO:0061360
term: optic chiasma development
ontology: BP
definition:
The developmental process pertaining to the progression of the optic chiasm from its initial formation to the mature structure. The process begins when the pathfinding of the axons of the developing optic nerve cause some axons to cross at the midline of the brain and ends when the axons are mature.


go_id: GO:0061361
term: positive regulation of maintenance of bipolar cell polarity regulating cell shape
ontology: BP
definition:
Any process that increases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape.


go_id: GO:0061362
term: negative regulation of maintenance of bipolar cell polarity regulating cell shape
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape.


go_id: GO:0061363
term: negative regulation of progesterone biosynthesis involved in luteolysis
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of the biosynthesis of progesterone biosynthesis that contributes to luteolysis.


go_id: GO:0061366
term: behavioral response to chemical pain
ontology: BP
definition:
Any process that results in a change in the behaviour of an organism as a result of a chemical pain stimulus.


go_id: GO:0061367
term: behavioral response to acetic acid induced pain
ontology: BP
definition:
Any process that results in a change in the behaviour of an organism as a result of an acetic acid pain stimulus.


go_id: GO:0061368
term: behavioral response to formalin induced pain
ontology: BP
definition:
Any process that results in a change in the behaviour of an organism as a result of a formalin pain stimulus.


go_id: GO:0061369
term: negative regulation of testicular blood vessel morphogenesis
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis in the testicle.


go_id: GO:0061370
term: testosterone biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5.


go_id: GO:0061371
term: determination of heart left/right asymmetry
ontology: BP
definition:
Determination of the asymmetric location of the heart with respect to the left and right halves of the organism.


go_id: GO:0061372
term: activin receptor signaling pathway involved in heart jogging
ontology: BP
definition:
A series of molecular signals initiated by the binding of a member of the activin family to a receptor on the surface of a target cell, and contributing to the process of heart jogging.


go_id: GO:0061373
term: mammillary axonal complex development
ontology: BP
definition:
The progression of the mammillary axonal complex over time, from its formation to the mature structure. The mammillary axonal complex is formed by the axons from the lateral, medial mammillary and the dorsal premammillary nuclei which share a branching pattern. Every neuron gives off one axonal stem that bifurcates into 2 branches. One of the branches is directed dorsally to the thalamus and another caudally to the midbrain.


go_id: GO:0061374
term: mammillothalamic axonal tract development
ontology: BP
definition:
The progression of the mammillothalamic axonal tract, from its formation to the mature structure. The mammillothalamic tract is the collection of axons that connects the two major subdivisions of the diencephalon (hypothalamus and thalamus) and closes the diencephalic circuit.


go_id: GO:0061375
term: mammillotectal axonal tract development
ontology: BP
definition:
The progression of the mammillotectal tract over time, from its formation to the mature structure. The mammillotectal tract is the collection of axons that connects the ventral diencephalon to the superior colliculus.


go_id: GO:0061376
term: mammillotegmental axonal tract development
ontology: BP
definition:
The process in which the mammillotegmental tract progresses over time, from its formation to the mature structure. The mammillotegmental tract is the collection of axons that connects the ventral diencephalon to the tegmentum and pons.


go_id: GO:0061377
term: mammary gland lobule development
ontology: BP
definition:
The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland.


go_id: GO:0061378
term: corpora quadrigemina development
ontology: BP
definition:
The progression of the corpora quadrigemina over time, from its formation to the mature structure. The corpora quadrigemina is a part of the midbrain that is made up of the superior and inferior colliculi.


go_id: GO:0061379
term: inferior colliculus development
ontology: BP
definition:
The process whose specific outcome is the progression of the inferior colliculus over time, from its formation to the mature structure. The inferior colliculus (IC) (Latin, lower hill) is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex. The inferior colliculus has three subdivisions: the central nucleus (CIC), a dorsal cortex (DCIC) by which it is surrounded, and an external cortex (ICX) which is located laterally.


go_id: GO:0061380
term: superior colliculus development
ontology: BP
definition:
The process whose specific outcome is the progression of the superior colliculus over time, from its formation to the mature structure. The superior colliculus is also known as the optic tectum or simply tectum and is a paired structure that forms a major component of the vertebrate midbrain.


go_id: GO:0061382
term: Malpighian tubule tip cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells.


go_id: GO:0061383
term: trabecula morphogenesis
ontology: BP
definition:
The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.


go_id: GO:0061384
term: heart trabecula morphogenesis
ontology: BP
definition:
The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.


go_id: GO:0061385
term: fibroblast proliferation involved in heart morphogenesis
ontology: BP
definition:
The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart.


go_id: GO:0061392
term: regulation of transcription from RNA polymerase II promoter in response to osmotic stress
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


go_id: GO:0061393
term: positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress
ontology: BP
definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


go_id: GO:0061394
ontology: BP
term:
regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance

definition:
Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.


go_id: GO:0061395
ontology: BP
term:
positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance

definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.


go_id: GO:0061396
term: regulation of transcription from RNA polymerase II promoter in response to copper ion
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus.


go_id: GO:0061397
term: positive regulation of transcription from RNA polymerase II promoter in response to copper ion
ontology: BP
definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus.


go_id: GO:0061399
term: positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion
ontology: BP
definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a cobalt ion stimulus.


go_id: GO:0061400
term: positive regulation of transcription from RNA polymerase II promoter in response to calcium ion
ontology: BP
definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a calcium ion stimulus.


go_id: GO:0061401
ontology: BP
term:
positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment

definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.


go_id: GO:0061402
term: positive regulation of transcription from RNA polymerase II promoter in response to acidic pH
ontology: BP
definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH stimulus with pH < 7.


go_id: GO:0061403
ontology: BP
term:
positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress

definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.


go_id: GO:0061404
term: positive regulation of transcription from RNA polymerase II promoter in response to increased salt
ontology: BP
definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.


go_id: GO:0061405
ontology: BP
term:
positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure

definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it.


go_id: GO:0061406
ontology: BP
term:
positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation

definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of glucose.


go_id: GO:0061407
ontology: BP
term:
positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide

definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus.


go_id: GO:0061408
term: positive regulation of transcription from RNA polymerase II promoter in response to heat stress
ontology: BP
definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.


go_id: GO:0061409
term: positive regulation of transcription from RNA polymerase II promoter in response to freezing
ontology: BP
definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a freezing stimulus, temperatures below 0 degrees Celsius.


go_id: GO:0061410
term: positive regulation of transcription from RNA polymerase II promoter in response to ethanol
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an ethanol stimulus.


go_id: GO:0061411
term: positive regulation of transcription from RNA polymerase II promoter in response to cold
ontology: BP
definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.


go_id: GO:0061412
ontology: BP
term:
positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation

definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of amino acids.


go_id: GO:0061413
term: regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source
ontology: BP
definition:
A transcription regulation process in which the presence of a nonfermentable carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.


go_id: GO:0061414
ontology: BP
term:
positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source

definition:
A transcription regulation process in which the presence of a nonfermentable carbon source leads to an increase of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.


go_id: GO:0061415
ontology: BP
term:
negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source

definition:
A transcription regulation process in which the presence of a nonfermentable carbon source leads to a decrease of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.


go_id: GO:0061416
term: regulation of transcription from RNA polymerase II promoter in response to salt stress
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.


go_id: GO:0061417
ontology: BP
term:
negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress

definition:
Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


go_id: GO:0061418
term: regulation of transcription from RNA polymerase II promoter in response to hypoxia
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.


go_id: GO:0061419
term: positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
ontology: BP
definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.


go_id: GO:0061420
term: regulation of transcription from RNA polymerase II promoter in response to biotin starvation
ontology: BP
definition:
Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of biotin.


go_id: GO:0061422
term: positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH
ontology: BP
definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH >7.0.


go_id: GO:0061423
ontology: BP
term:
positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter

definition:
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter resulting in the increased frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0061424
ontology: BP
term:
positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter

definition:
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of peroxisome organization.


go_id: GO:0061425
ontology: BP
term:
positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter

definition:
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of an ethanol catabolic process.


go_id: GO:0061426
ontology: BP
term:
positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter

definition:
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of sulfite transport.


go_id: GO:0061427
ontology: BP
term:
negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter

definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter and stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process.


go_id: GO:0061428
term: negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.


go_id: GO:0061429
term: positive regulation of transcription from RNA polymerase II promoter by oleic acid
ontology: BP
definition:
Any process involving oleic acid that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.


go_id: GO:0061430
term: bone trabecula morphogenesis
ontology: BP
definition:
The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod.


go_id: GO:0061431
term: cellular response to methionine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus.


go_id: GO:0061432
term: regulation of transcription from RNA polymerase II promoter in response to methionine
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a methionine stimulus.


go_id: GO:0061433
term: cellular response to caloric restriction
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake.


go_id: GO:0061434
ontology: BP
term:
regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction

definition:
Any process that modulates the frequency, rate or extent of replicative cell aging through a mechanism that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a caloric restriction stimulus.


go_id: GO:0061435
term: positive regulation of transcription from a mobile element promoter
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of transcription from a mobile element promoter.


go_id: GO:0061436
term: establishment of skin barrier
ontology: BP
definition:
Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.


go_id: GO:0061437
term: renal system vasculature development
ontology: BP
definition:
The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure.


go_id: GO:0061438
term: renal system vasculature morphogenesis
ontology: BP
definition:
The process in which the renal system vasculature is generated and organized. Morphogenesis pertains to the creation of form.


go_id: GO:0061439
term: kidney vasculature morphogenesis
ontology: BP
definition:
The process in which the kidney vasculature is generated and organized. Morphogenesis pertains to the creation of form.


go_id: GO:0061440
term: kidney vasculature development
ontology: BP
definition:
The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure.


go_id: GO:0061441
term: renal artery morphogenesis
ontology: BP
definition:
The process in which the anatomical structure of a renal artery is generated and organized. Renal arteries supply the kidneys with blood.


go_id: GO:0061442
term: cardiac muscle cell fate determination
ontology: BP
definition:
The process involved in cardiac muscle cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.


go_id: GO:0061443
term: endocardial cushion cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell.


go_id: GO:0061444
term: endocardial cushion cell development
ontology: BP
definition:
The process whose specific outcome is the progression of an endocardial cushion cell over time, from its formation to the mature state.


go_id: GO:0061445
term: endocardial cushion cell fate commitment
ontology: BP
definition:
The commitment of a cell to an endocardial cushion cell fate and its capacity to differentiate into an endocardial cushion cell.


go_id: GO:0061446
term: endocardial cushion cell fate determination
ontology: BP
definition:
The process involved in endocardial cushion cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.


go_id: GO:0061447
term: endocardial cushion cell fate specification
ontology: BP
definition:
The process involved in the specification of endocardial cushion cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.


go_id: GO:0061449
term: olfactory bulb tufted cell development
ontology: BP
definition:
The process whose specific outcome is the progression of an olfactory bulb tufted cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.


go_id: GO:0061450
term: trophoblast cell migration
ontology: BP
definition:
Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst.


go_id: GO:0061451
term: retrotrapezoid nucleus development
ontology: BP
definition:
The progression of the retrotrapezoid nucleus (RTN) over time from it's initial formation to its mature state. The retrotrapezoid nucleus is a group of neurons in the rostral medulla, which are responsible regulating respiration.


go_id: GO:0061452
term: retrotrapezoid nucleus neuron differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the retrotrapezoid nucleus.


go_id: GO:0061453
term: interstitial cell of Cajal differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction.


go_id: GO:0061455
term: integral component of muscle cell projection membrane
ontology: CC
definition:
The component of the muscle cell projection membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0061456
term: mesenchymal stem cell migration involved in uteric bud morphogenesis
ontology: BP
definition:
The orderly movement of a mesenchymal stem cell from one site to another contributing to the shaping of the ureteric bud. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.


go_id: GO:0061457
term: mesonephric cell migration involved in male gonad development
ontology: BP
definition:
The orderly movement of a cell from the mesonephros to the male gonad, contributing to its development.


go_id: GO:0061458
term: reproductive system development
ontology: BP
definition:
The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction.


go_id: GO:0061459
term: L-arginine transmembrane transporter activity
ontology: MF
definition:
Enables the stereospecific transfer of L-arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane.


go_id: GO:0061467
term: basolateral protein localization
ontology: BP
definition:
Any process in which a protein is transported to, or maintained in, basolateral regions of the cell.


go_id: GO:0061468
term: karyomere
ontology: CC
definition:
A membrane-bound intermediate cleavage-stage structure of individual or groups of chromosomes that coalesces and fuses with other karyomeres to form a nucleus during interphase. Karyomere formation occurs in blastomeres undergoing rapid cell division.


go_id: GO:0061470
term: T follicular helper cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell.


go_id: GO:0061471
term: karyomere assembly
ontology: BP
definition:
The process where the nuclear membrane engulfs condensed chromosomes to form karyomeres during M phase of the mitotic cell cycle.


go_id: GO:0061473
term: murein tripeptide carboxypeptidase activity
ontology: MF
definition:
Catalysis of the reaction L-Ala-gamma;-D-Glu-meso-Dap (murein tripeptide) + H2O = L-Ala-&gamma;-D-Glu + meso-diaminopimelate.


go_id: GO:0061475
term: cytosolic valyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling valine to valyl-tRNA in the cytosol, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0061476
term: response to anticoagulant
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticoagulant stimulus.


go_id: GO:0061477
term: response to aromatase inhibitor
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aromatase inhibitor stimulus.


go_id: GO:0061478
term: response to platelet aggregation inhibitor
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet aggregation inhibitor stimulus.


go_id: GO:0061479
term: response to reverse transcriptase inhibitor
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reverse transcriptase inhibitor stimulus.


go_id: GO:0061480
term: response to asparaginase
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an asparaginase stimulus.


go_id: GO:0061481
term: response to TNF agonist
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a TNF agonist stimulus.


go_id: GO:0061482
term: response to irinotecan
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an irinotecan stimulus.


go_id: GO:0061483
term: sulfinylpropanyl adenylate synthase
ontology: MF
definition:
Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H(+) + phosphate.


go_id: GO:0061484
term: hematopoietic stem cell homeostasis
ontology: BP
definition:
Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells.


go_id: GO:0061486
term: high-affinity fructose transmembrane transporter activity
ontology: MF
definition:
Catalysis of the transfer of fructose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


go_id: GO:0061487
term: DNA replication initiation from late origin
ontology: BP
definition:
The process in which DNA-dependent DNA replication is started at a late origin of replication. A late origin of replication refers to an origin that is activated late in S phase.


go_id: GO:0061488
term: adenine import into cell
ontology: BP
definition:
The directed movement of adenine from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.


go_id: GO:0061489
term: guanine import into cell
ontology: BP
definition:
The directed movement of guanine from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.


go_id: GO:0061490
term: glucose import into cell
ontology: BP
definition:
The directed movement of glucose from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.


go_id: GO:0061491
term: serine import into cell
ontology: BP
definition:
The directed movement of serine from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.


go_id: GO:0061492
term: asymmetric protein localization to old or new spindle pole body
ontology: BP
definition:
Any process in which a protein is transported to, or maintained to either the old or new spindle pole body resulting in its being distributed asymmetrically.


go_id: GO:0061493
term: central plaque of mitotic spindle pole body
ontology: CC
definition:
One of three laminate structures that form the mitotic spindle pole body; the central plaque is embedded in the nuclear envelope.


go_id: GO:0061494
term: gamma-tubulin large complex, mitotic spindle pole body
ontology: CC
definition:
A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located in the mitotic spindle pole body.


go_id: GO:0061495
term: gamma-tubulin small complex, mitotic spindle pole body
ontology: CC
definition:
A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins located in the mitotic spindle pole body and isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae.


go_id: GO:0061497
term: inner plaque of mitotic spindle pole body
ontology: CC
definition:
One of three laminate structures that form the mitotic spindle pole body; the inner plaque is in the nucleus.


go_id: GO:0061499
term: outer plaque of mitotic spindle pole body
ontology: CC
definition:
One of three laminate structures that form the mitotic spindle pole body; the outer plaque is in the cytoplasm.


go_id: GO:0061500
term: gene conversion at mating-type locus, termination of copy-synthesis
ontology: BP
definition:
A DNA replication termination process that is part of gene conversion at a mating-type locus and takes place at a specific termination site.


go_id: GO:0061502
term: early endosome to recycling endosome transport
ontology: BP
definition:
The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes.


go_id: GO:0061504
term: cyclic threonylcarbamoyladenosine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.


go_id: GO:0061505
term: DNA topoisomerase II activity
ontology: MF
definition:
Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; changes the linking number in multiples of 2.


go_id: GO:0061506
term: DNA topoisomerase type II (ATP-independent) activity
ontology: MF
definition:
Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is not coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.


go_id: GO:0061509
term: asymmetric protein localization to old mitotic spindle pole body
ontology: BP
definition:
Any process in which a protein is transported to, or maintained to the old mitotic spindle pole body resulting in its being distributed asymmetrically.


go_id: GO:0061510
term: asymmetric protein localization to new mitotic spindle pole body
ontology: BP
definition:
Any process in which a protein is transported to, or maintained to the new mitotic spindle pole body resulting in its being distributed asymmetrically.


go_id: GO:0061511
term: centriole elongation
ontology: BP
definition:
The centrosome organization process by which a centriole increases in length as part of the process of replication.


go_id: GO:0061513
term: glucose 6-phosphate:inorganic phosphate antiporter activity
ontology: MF
definition:
Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + inorganic phosphate(in) = glucose 6-phosphate(in) + inorganic phosphate(out).


go_id: GO:0061514
term: interleukin-34-mediated signaling pathway
ontology: BP
definition:
A series of molecular signals initiated by the binding of interleukin-34 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0061515
term: myeloid cell development
ontology: BP
definition:
The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure.


go_id: GO:0061519
term: macrophage homeostasis
ontology: BP
definition:
The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.


go_id: GO:0061521
term: hepatic stellate cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a hepatic stellate cell.


go_id: GO:0061524
term: central canal development
ontology: BP
definition:
The process whose specific outcome is the formation of the central canal of the spinal cord from its formation to the mature structure. The central canal is a spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord.


go_id: GO:0061525
term: hindgut development
ontology: BP
definition:
The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut.


go_id: GO:0061532
term: primary amine secretion, neurotransmission
ontology: BP
definition:
The regulated release of a primary amine by a cell, in which the primary amine acts as a neurotransmitter.


go_id: GO:0061533
term: norepinephrine secretion, neurotransmission
ontology: BP
definition:
The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter.


go_id: GO:0061534
term: gamma-aminobutyric acid secretion, neurotransmission
ontology: BP
definition:
The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter.


go_id: GO:0061541
term: rhabdomere morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of a rhabdomere are generated and organized. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments.


go_id: GO:0061542
term: 3-demethylubiquinone-n 3-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.


go_id: GO:0061543
term: 3-demethylubiquinone-6 3-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-6 = S-adenosyl-L-homocysteine + ubiquinone-6.


go_id: GO:0061547
term: glycogen synthase activity, transferring glucose-1-phosphate
ontology: MF
definition:
Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate.


go_id: GO:0061548
term: ganglion development
ontology: BP
definition:
The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure.


go_id: GO:0061549
term: sympathetic ganglion development
ontology: BP
definition:
The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.


go_id: GO:0061550
term: cranial ganglion development
ontology: BP
definition:
The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.


go_id: GO:0061551
term: trigeminal ganglion development
ontology: BP
definition:
The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.


go_id: GO:0061553
term: ganglion maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state.


go_id: GO:0061554
term: ganglion formation
ontology: BP
definition:
The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts.


go_id: GO:0061555
term: ganglion structural organization
ontology: BP
definition:
The process that contributes to creating the structural organization of a ganglion. This process pertains to the physical shaping of a rudimentary structure.


go_id: GO:0061557
term: trigeminal ganglion maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state.


go_id: GO:0061558
term: cranial ganglion maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state.


go_id: GO:0061560
term: cranial ganglion formation
ontology: BP
definition:
The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts.


go_id: GO:0061561
term: trigeminal ganglion formation
ontology: BP
definition:
The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts.


go_id: GO:0061562
term: cranial ganglion structural organization
ontology: BP
definition:
The process that contributes to creating the structural organization of a cranial ganglion. This process pertains to the physical shaping of a rudimentary structure.


go_id: GO:0061563
term: trigeminal ganglion structural organization
ontology: BP
definition:
The process that contributes to creating the structural organization of the trigeminal ganglion This process pertains to the physical shaping of a rudimentary structure.


go_id: GO:0061564
term: axon development
ontology: BP
definition:
The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation).


go_id: GO:0061565
term: dAMP phosphorylation
ontology: BP
definition:
The process of introducing a phosphate group into dAMP, deoxyadenosine monophosphate, to produce dADP. Addition of two phosphate groups produces dATP.


go_id: GO:0061566
term: CMP phosphorylation
ontology: BP
definition:
The process of introducing a phosphate group into CMP, cytidine monophosphate, to produce CDP. Addition of two phosphate groups produces CTP.


go_id: GO:0061567
term: dCMP phosphorylation
ontology: BP
definition:
The process of introducing a phosphate group into dCMP, deoxycytidine monophosphate, to produce dCDP. Addition of two phosphate groups produces dCTP.


go_id: GO:0061572
term: actin filament bundle organization
ontology: BP
definition:
A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.


go_id: GO:0061573
term: actin filament bundle retrograde transport
ontology: BP
definition:
A process of actin filament bundle distribution that results in the arrangement of actin filament bundles from the periphery toward the interior of the cell.


go_id: GO:0061574
term: ASAP complex
ontology: CC
definition:
A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.


go_id: GO:0061576
term: acyl-CoA ceramide synthase complex
ontology: CC
definition:
A protein complex that catalyzes the reaction acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae it contains three subunits: lag1, lac1 and lip1.


go_id: GO:0061577
term: generation of L-type calcium current
ontology: BP
definition:
A process in which a calcium ion is transported from one side of a membrane to the other by means of an L-type calcium channel.


go_id: GO:0061579
term: N-acyl homoserine lactone synthase activity
ontology: MF
definition:
Catalyzing the reaction: acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine -> [acyl-carrier- protein] + S-methyl-5'-thioadenosine + N-acyl-L-homoserine lactone.


go_id: GO:0061580
term: colon epithelial cell migration
ontology: BP
definition:
The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism.


go_id: GO:0061581
term: corneal epithelial cell migration
ontology: BP
definition:
The orderly movement of a corneal  epithelial cell from one site to another, often during the development of a multicellular organism.


go_id: GO:0061582
term: intestinal epithelial cell migration
ontology: BP
definition:
The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism.


go_id: GO:0061583
term: colon epithelial cell chemotaxis
ontology: BP
definition:
The directed movement of a colon epithelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).


go_id: GO:0061585
term: hypocretin secretion, neurotransmission
ontology: BP
definition:
The controlled release of a peptide from a cell or a tissue in which the peptide acts as a neurotransmitter.


go_id: GO:0061586
term: positive regulation of transcription by transcription factor localization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor.


go_id: GO:0061587
term: transfer RNA gene-mediated silencing
ontology: BP
definition:
The chromatin silencing that results in the inhibition of RNA polymerase II-transcribed genes located in the vicinity of tRNA genes.


go_id: GO:0061588
term: calcium activated phospholipid scrambling
ontology: BP
definition:
The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.


go_id: GO:0061589
term: calcium activated phosphatidylserine scrambling
ontology: BP
definition:
The movement of a population of phosphatidylserine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.


go_id: GO:0061590
term: calcium activated phosphatidylcholine scrambling
ontology: BP
definition:
The movement of a population of phosphatidylcholine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.


go_id: GO:0061591
term: calcium activated galactosylceramide scrambling
ontology: BP
definition:
The movement of a population of galactosylceramide molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.


go_id: GO:0061592
term: phosphatidylserine exposure on osteoblast involved in bone mineralization
ontology: BP
definition:
A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of osteoblasts, and contributes to bone mineralization.


go_id: GO:0061594
term: 6-deoxy-6-sulfofructose kinase activity
ontology: MF
definition:
Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP.


go_id: GO:0061595
term: 6-deoxy-6-sulfofructose-1-phosphate aldolase activity
ontology: MF
definition:
Catalysis of the reaction 6-deoxy-6-sulfofructose-1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate.


go_id: GO:0061596
term: 3-sulfolactaldehyde reductase activity
ontology: MF
definition:
Catalysis of the reaction 2,3-dihydroxypropane-1-sulfonate + NAD+ = 3-sulfolactaldehyde + NADH + H+.


go_id: GO:0061604
term: molybdopterin-synthase sulfurtransferase activity
ontology: MF
definition:
Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine <=> AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase.


go_id: GO:0061605
term: molybdopterin-synthase adenylyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP.


go_id: GO:0061607
term: peptide alpha-N-propionyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: propionyl-CoA + peptide = CoA + N-alpha-propionylpeptide. This reaction is the propionylation of the N-terminal amino acid residue of a peptide or protein.


go_id: GO:0061608
term: nuclear import signal receptor activity
ontology: MF
definition:
Combining with a nuclear import signal (NIS) to mediate transport of the NIS-containing protein through the nuclear pore to the nucleus.


go_id: GO:0061610
term: glycerol to glycerone phosphate metabolic process
ontology: BP
definition:
The chemical reactions and pathways in which glycerol, 1,2,3-propanetriol, is converted to glycerone phosphate.


go_id: GO:0061611
term: mannose to fructose-6-phosphate metabolic process
ontology: BP
definition:
The chemical reactions and pathways in which mannose, the aldohexose manno-hexose, is converted to fructose-6-phosphate.


go_id: GO:0061612
term: galactose to glucose-1-phosphate metabolic process
ontology: BP
definition:
The chemical reactions and pathways in which galactose, the aldohexose galacto-hexose, is converted to glucose-1-phosphate.


go_id: GO:0061614
term: pri-miRNA transcription from RNA polymerase II promoter
ontology: BP
definition:
The cellular synthesis of primary microRNA (pri-miRNA) transcripts from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. pri-miRNA transcripts are subsequently processed to produce the ~22nt miRNAs that function in gene regulation.


go_id: GO:0061615
term: glycolytic process through fructose-6-phosphate
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH.


go_id: GO:0061617
term: MICOS complex
ontology: CC
definition:
Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60.


go_id: GO:0061618
term: sublamina densa
ontology: CC
definition:
The part of the basement membrane that lies beneath the lamina densa, containing anchoring fibrils, anchoring plaques, collagen fibers, and elastic fibers.


go_id: GO:0061619
term: glycolytic process from mannose through fructose-6-phosphate
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of mannose into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH.


go_id: GO:0061620
term: glycolytic process through glucose-6-phosphate
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP.


go_id: GO:0061621
term: canonical glycolysis
ontology: BP
definition:
The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the  chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.


go_id: GO:0061622
term: glycolytic process through glucose-1-phosphate
ontology: BP
definition:
The chemical reactions and pathways through a glucose-1-phosphate intermediate that result in the catabolism of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.


go_id: GO:0061623
term: glycolytic process from galactose
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP.


go_id: GO:0061624
term: fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of fructose that results in the formation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate.


go_id: GO:0061625
term: glycolytic process through fructose-1-phosphate
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of fructose into pyruvate through a fructose-1-phosphate intermediate, with the concomitant production of ATP and NADH.


go_id: GO:0061626
term: pharyngeal arch artery morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery.


go_id: GO:0061628
term: H3K27me3 modified histone binding
ontology: MF
definition:
Interacting selectively and non-covalently with a histone H3 in which the lysine residue at position 27 has been modified by trimethylation.


go_id: GO:0061629
term: RNA polymerase II sequence-specific DNA binding transcription factor binding
ontology: MF
definition:
Interacting selectively and non-covalently with a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.


go_id: GO:0061630
term: ubiquitin protein ligase activity
ontology: MF
definition:
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S --> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate. Note that this may include the extension of ubiquitin chains.


go_id: GO:0061631
term: ubiquitin conjugating enzyme activity
ontology: MF
definition:
Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.


go_id: GO:0061632
term: RNA lariat debranching enzyme activator activity
ontology: MF
definition:
Increases the activity of an enzyme that catalyzes the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide.


go_id: GO:0061633
term: transport-coupled glycolytic process through glucose-6-phosphate
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, in which the glucose is converted to glucose-6-phosphate intermediate coupled to transmembrane transport.


go_id: GO:0061634
term: alpha-D-xyloside xylohydrolase
ontology: MF
definition:
Catalysis of the hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose.


go_id: GO:0061635
term: regulation of protein complex stability
ontology: BP
definition:
Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly.


go_id: GO:0061636
term: mitotic anaphase-promoting complex activator activity
ontology: MF
definition:
Increases the activity of a mitotic anaphase promoting complex, an ubiquitin-protein transferase activity that regulates the mitotic metaphase/anaphase transition.


go_id: GO:0061637
term: mitotic anaphase-promoting complex inhibitor activity
ontology: MF
definition:
Prevents the activation of a mitotic anaphase promoting complex, a ubiquitin-protein transferase activity that regulates mitotic cell cycle transitions.


go_id: GO:0061638
term: CENP-A containing chromatin
ontology: CC
definition:
The specialized chromatin located the centromeric core region or the entire centromeric region in organisms with point centromeres, which is enriched for CENP-A-containing nucleosomes. This chromatin forms a 3-dimensional structure which provides a platform for kinetochore assembly and microtubule attachment.


go_id: GO:0061639
term: Cdv-dependent cytokinesis
ontology: BP
definition:
A cytokinesis that involves a set of conserved proteins including the Cdv proteins, and results in the formation of two similarly sized and shaped cells.


go_id: GO:0061640
term: cytoskeleton-dependent cytokinesis
ontology: BP
definition:
A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton.


go_id: GO:0061641
term: CENP-A containing chromatin organization
ontology: BP
definition:
Any process that results in the specification, formation or maintenance of the physical structure of CENP-A containing chromatin.


go_id: GO:0061642
term: chemoattraction of axon
ontology: BP
definition:
The process in which a neuron growth cone is directed to a specific target site in response to an attractive chemical signal.


go_id: GO:0061643
term: chemorepulsion of axon
ontology: BP
definition:
The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.


go_id: GO:0061645
term: endocytic patch
ontology: CC
definition:
The part of the cell cortex consisting of  an aggregation of proteins that will give rise to an endocytic vesicle.


go_id: GO:0061646
term: positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of glutamate secretion in response to membrane depolarization, where glutamate acts as a neurotransmitter.


go_id: GO:0061649
term: ubiquitinated histone binding
ontology: MF
definition:
Interacting selectively and non-covalently with a histone protein in which a residue has been modified by ubiquitination. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.


go_id: GO:0061650
term: ubiquitin-like protein conjugating enzyme activity
ontology: MF
definition:
Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y -> Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue.


go_id: GO:0061651
term: Atg12 conjugating enzyme activity
ontology: MF
definition:
Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y -> Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue.


go_id: GO:0061652
term: FAT10 conjugating enzyme activity
ontology: MF
definition:
Isoenergetic transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y -> Y-FAT10 + X, where both the X-FAT10 and Y-FAT10 linkages are thioester bonds between the C-terminal amino acid of FAT10 and a sulfhydryl side group of a cysteine residue.


go_id: GO:0061653
term: ISG15 conjugating enxyme activity
ontology: MF
definition:
Isoenergetic transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y -> Y-ISG15 + X, where both the X-ISG15 and Y-ISG15 linkages are thioester bonds between the C-terminal amino acid of ISG15 and a sulfhydryl side group of a cysteine residue.


go_id: GO:0061654
term: NEDD8 conjugating enzyme activity
ontology: MF
definition:
Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y -> Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue.


go_id: GO:0061655
term: Pup conjugating enzyme activity
ontology: MF
definition:
Isoenergetic transfer of Pup from one protein to another via the reaction X-Pup + Y -> Y-Pup + X, where both the X-Pup and Y-Pup linkages are thioester bonds between the C-terminal amino acid of Pup and a sulfhydryl side group of a cysteine residue.


go_id: GO:0061656
term: SUMO conjugating enzyme activity
ontology: MF
definition:
Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y -> Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue.


go_id: GO:0061657
term: UFM1 conjugating enzyme activity
ontology: MF
definition:
Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y -> Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue.


go_id: GO:0061658
term: URM1 conjugating enzyme activity
ontology: MF
definition:
Isoenergetic transfer of URM1 from one protein to another via the reaction X-URM1 + Y -> Y-URM1 + X, where both the X-URM1 and Y-URM1 linkages are thioester bonds between the C-terminal amino acid of URM1 and a sulfhydryl side group of a cysteine residue.


go_id: GO:0061659
term: ubiquitin-like protein ligase activity
ontology: MF
definition:
Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate.


go_id: GO:0061660
term: Atg12 ligase activity
ontology: MF
definition:
Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S --> X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate.


go_id: GO:0061661
term: FAT10 ligase activity
ontology: MF
definition:
Catalysis of the transfer of FAT10 to a substrate protein via the reaction X-FAT10 + S --> X + S-FAT10, where X is either an E2 or E3 enzyme, the X-FAT10 linkage is a thioester bond, and the S-FAT10 linkage is an isopeptide bond between the C-terminal glycine of FAT10 and the epsilon-amino group of lysine residues in the substrate.


go_id: GO:0061662
term: ISG15 ligase activity
ontology: MF
definition:
Catalysis of the transfer of a ISG15 to a substrate protein via the reaction X-ISG15 + S --> X + S-ISG15, where X is either an E2 or E3 enzyme, the X-ISG15 linkage is a thioester bond, and the S-ISG15 linkage is an isopeptide bond between the C-terminal amino acid of ISG15 and the epsilon-amino group of lysine residues in the substrate.


go_id: GO:0061663
term: NEDD8 ligase activity
ontology: MF
definition:
Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate.


go_id: GO:0061664
term: Pup ligase activity
ontology: MF
definition:
Catalysis of the transfer of Pup to a substrate protein via the reaction X-Pup + S --> X + S-Pup, where X is either an E2 or E3 enzyme, the X-Pup linkage is a thioester bond, and the S-Pup linkage is an isopeptide bond between the C-terminal amino acid of Pup and the epsilon-amino group of lysine residues in the substrate.


go_id: GO:0061665
term: SUMO ligase activity
ontology: MF
definition:
Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S --> X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate.


go_id: GO:0061666
term: UFM1 ligase activity
ontology: MF
definition:
Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S --> X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate.


go_id: GO:0061667
term: URM1 ligase activity
ontology: MF
definition:
Catalysis of the transfer of URM1 to a substrate protein via the reaction X-URM1 + S --> X + S-URM1, where X is either an E2 or E3 enzyme, the X-URM1 linkage is a thioester bond, and the S-URM1 linkage is an isopeptide bond between the C-terminal amino acid of URM1 and the epsilon-amino group of lysine residues in the substrate.


go_id: GO:0061668
term: mitochondrial ribosome assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits.


go_id: GO:0061669
term: spontaneous neurotransmitter secretion
ontology: BP
definition:
Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential.


go_id: GO:0061670
term: evoked neurotransmitter secretion
ontology: BP
definition:
Neurotransmitter secretion that occurs in the presence of the action of a secretagogue or a presynaptic action potential.


go_id: GO:0061671
term: Cbp3p-Cbp6 complex
ontology: CC
definition:
A protein complex located at the mitochondrial ribosome tunnel exit that is involved in efficient translation and protein complex assembly.


go_id: GO:0061672
term: glutathione hydrolase complex
ontology: CC
definition:
Enzyme complex that in S. cerevisiae has compnents Dug2/Dug3 and is able to catalyze the cleavage of glutathione into glutamate and Cys-Gly.


go_id: GO:0061673
term: mitotic spindle astral microtubule
ontology: CC
definition:
Any of the mitotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.


go_id: GO:0061674
term: gap filling involved in double-strand break repair via nonhomologous end joining
ontology: BP
definition:
Repair of the gaps in the DNA helix using a discontinuous template during double-strand break repair via nonhomologous end joining.


go_id: GO:0061675
term: RBL family protein binding
ontology: MF
definition:
Interacting selectively and non-covalently with any member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose.


go_id: GO:0061678
term: Entner-Doudoroff pathway
ontology: BP
definition:
A cellular carbohydrate catabolic process that converts a carbohydrate to pyruvate and either glyceraldehyde or glyceraldehyde-3 phosphate by dehydration and aldol cleavage via a gluconate or 6-phosphogluconate intermediate.


go_id: GO:0061680
term: Entner-Doudoroff pathway through gluconate to D-glyceraldehyde
ontology: BP
definition:
The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde.


go_id: GO:0061681
term: Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate
ontology: BP
definition:
The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate.


go_id: GO:0061683
term: branching involved in seminal vesicle morphogenesis
ontology: BP
definition:
The process in which the branching structure of the seminal vesicle is generated and organized. A branch is a division or offshoot from a main stem.


go_id: GO:0061684
term: chaperone-mediated autophagy
ontology: BP
definition:
The autophagy process which begins when chaperones and co-chaperones recognize a KFERQ-related motif and unfold the substrate protein. The process ends with the translocation of the protein across the lysosomal membrane.


go_id: GO:0061686
term: hercynylcysteine sulfoxide synthase
ontology: MF
definition:
Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine + O2 <=> hercynylcysteine sulfoxide + H2O.


go_id: GO:0061687
term: detoxification of inorganic compound
ontology: BP
definition:
Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds.


go_id: GO:0061688
term: glycolytic process via Entner-Doudoroff Pathway
ontology: BP
definition:
A glycolytic process in which the glucose is catabolized to pyruvate by first entering the Entner-Doudoroff pathway to yield pyruvate and glyceraldehyde-3-phosphate. The glyceraldehyde-3-phosphate is subsequently converted to pyruvate by the core glycolytic enzymes.


go_id: GO:0061689
term: tricellular tight junction
ontology: CC
definition:
An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet.


go_id: GO:0061691
term: detoxification of hydrogen peroxide
ontology: BP
definition:
Any process that reduces or removes the toxicity of hydrogen peroxide. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration.


go_id: GO:0061692
term: cellular detoxification of hydrogen peroxide
ontology: BP
definition:
Any process that reduces or removes the toxicity of hydrogen peroxide in a cell. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration.


go_id: GO:0061693
term: alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine.


go_id: GO:0061694
term: alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex
ontology: CC
definition:
A catalytic protein complex that is capable of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity.


go_id: GO:0061695
term: transferase complex, transferring phosphorus-containing groups
ontology: CC
definition:
A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).


go_id: GO:0061696
term: pituitary gonadotropin complex
ontology: CC
definition:
A protein complex that is a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. capable of regulating normal growth, sexual development, and reproductive function.


go_id: GO:0061697
term: protein-glutaryllysine deglutarylase activity
ontology: MF
definition:
Catalysis of the reaction: protein-glutaryllysine + H2O => protein-lysine + glutarate. This reaction is the removal of a glutaryl group from a glutarylated lysine residue of a protein or peptide.


go_id: GO:0061699
term: peptidyl-lysine deglutarylation
ontology: BP
definition:
The removal of a glutaryl group (CO-CH2-CH2--CH2-CO) from a glutarylated lysine residue in a peptide or protein.


go_id: GO:0061700
term: GATOR2 complex
ontology: CC
definition:
A multiprotein subcomplex of GATOR that regulates mTOR signlaing by interacting with the Rag GTPases. In humans this complex consists of Mios, WDR24, WDR59, Seh1L, Sec13.


go_id: GO:0061703
term: pyroptosome complex
ontology: CC
definition:
A protein complex that consists of an assemble of ASC dimers that is capable of inducing pyroptosis.


go_id: GO:0061704
term: glycolytic process from sucrose
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a sucrose into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.


go_id: GO:0061705
term: sucrose catabolic process to fructose-6-phosphate through glucose and fructose
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of sucrose, to yield fructose-6-phosphate through both glucose and fructose intermediates.


go_id: GO:0061706
term: glycolytic process from sucrose through glucose and fructose
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of sucrose into pyruvate through both glucose and fructose intermediates, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.


go_id: GO:0061707
term: extracellular exosome macropinocytosis
ontology: BP
definition:
The single-organism macropinocytosis process that results in the uptake of an extracellular exosome.


go_id: GO:0061708
term: tRNA-5-taurinomethyluridine 2-sulfurtransferase
ontology: MF
definition:
Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+.


go_id: GO:0061709
term: reticulophagy
ontology: BP
definition:
The autophagic process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions.


go_id: GO:0061710
term: L-threonylcarbamoyladenylate synthase
ontology: MF
definition:
Catalysis of the reaction:  L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H(2)O.


go_id: GO:0061711
term: N(6)-L-threonylcarbamoyladenine synthase
ontology: MF
definition:
Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA.


go_id: GO:0061712
term: tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase
ontology: MF
definition:
Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine.


go_id: GO:0061713
term: anterior neural tube closure
ontology: BP
definition:
The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline.


go_id: GO:0061714
term: folic acid receptor activity
ontology: MF
definition:
Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis.


go_id: GO:0061715
term: miRNA 2'-O-methylation
ontology: BP
definition:
The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an miRNA molecule.


go_id: GO:0061718
term: glucose catabolic process to pyruvate
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of glucose, with the production of pyruvate.


go_id: GO:0061719
term: glucose catabolic process to pyruvate utilizing ADP
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, with the concomitant production of a small amount of ATP and the utilization of ADP in the initial kinase reactions.


go_id: GO:0061720
term: 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfolactaldehyde (SLA).


go_id: GO:0061721
term: 6-sulfoquinovose(1-) catabolic process to 3-sulfopropanediol(1-)
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfopropanediol(1-).


go_id: GO:0061722
term: sulphoglycolysis
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and pyruvate.


go_id: GO:0061723
term: glycophagy
ontology: BP
definition:
The autophagic process in which cellular glycogen is delivered to the vacuole and degraded in response to changing cellular conditions.


go_id: GO:0061724
term: lipophagy
ontology: BP
definition:
The autophagic process in which lipid droplets are delivered to the vacuole and degraded in response to changing cellular conditions.


go_id: GO:0061725
term: cytosolic lipolysis
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases.


go_id: GO:0061727
term: methylglyoxal catabolic process to lactate
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into lactate.


go_id: GO:0061729
term: GDP-mannose biosynthetic process from fructose-6-phosphate
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of GDP-mannose from fructose-6-phosphate.


go_id: GO:0061731
term: ribonucleoside-diphosphate reductase activity
ontology: MF
definition:
Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor.


go_id: GO:0061732
term: mitochondrial acetyl-CoA biosynthetic process from pyruvate
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate in the mitochondrion. The process begins with the transport of pyruvate from the cytosol to the mitochondrion where it is subsequently decarboxylated to form acetyl-CoA.


go_id: GO:0061734
term: parkin-mediated mitophagy in response to mitochondrial depolarization
ontology: BP
definition:
The macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule.


go_id: GO:0061735
term: dynamin-like protein-mediated mitophagy in response to mitochondrial depolarization
ontology: BP
definition:
The macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a dynamin-like molecule.


go_id: GO:0061736
term: engulfment of target by autophagosome
ontology: BP
definition:
The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy.


go_id: GO:0061737
term: leukotriene signaling pathway
ontology: BP
definition:
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-leukotriene interaction and ends with regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0065001
term: specification of axis polarity
ontology: BP
definition:
The pattern specification process in which the polarity of a body or organ axis is established and maintained.


go_id: GO:0065002
term: intracellular protein transmembrane transport
ontology: BP
definition:
The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.


go_id: GO:0065005
term: protein-lipid complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex.


go_id: GO:0065006
term: protein-carbohydrate complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of proteins and carbohydrates to form a protein-carbohydrate complex.


go_id: GO:0065008
term: regulation of biological quality
ontology: BP
definition:
Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.


go_id: GO:0065009
term: regulation of molecular function
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.


go_id: GO:0065010
term: extracellular membrane-bounded organelle
ontology: CC
definition:
Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell.


go_id: GO:0070001
term: aspartic-type peptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.


go_id: GO:0070002
term: glutamic-type peptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.


go_id: GO:0070003
term: threonine-type peptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.


go_id: GO:0070004
term: cysteine-type exopeptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


go_id: GO:0070005
term: cysteine-type aminopeptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.


go_id: GO:0070006
term: metalloaminopeptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


go_id: GO:0070007
term: glutamic-type endopeptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad.


go_id: GO:0070008
term: serine-type exopeptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


go_id: GO:0070009
term: serine-type aminopeptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of a peptide bond not more than three residues from the N-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).


go_id: GO:0070012
term: oligopeptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds.


go_id: GO:0070014
term: sucrase-isomaltase complex
ontology: CC
definition:
A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities.


go_id: GO:0070016
term: armadillo repeat domain binding
ontology: MF
definition:
Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation.


go_id: GO:0070018
term: transforming growth factor beta type I receptor homodimeric complex
ontology: CC
definition:
A receptor complex that consists of two transforming growth factor beta (TGF-beta) type I receptor monomers. TGF-beta type I receptor dimers form in the presence or absence of ligand, and can associate with ligand-bound TGF-beta type II receptor dimers.


go_id: GO:0070019
term: transforming growth factor beta type II receptor homodimeric complex
ontology: CC
definition:
A receptor complex that consists of two transforming growth factor beta (TGF-beta) type II receptor monomers. TGF-beta type II receptor dimers form in the presence or absence of ligand, and upon ligand binding can associate with TGF-beta type I receptor dimers.


go_id: GO:0070020
term: transforming growth factor beta1-type II receptor complex
ontology: CC
definition:
A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer.


go_id: GO:0070021
term: transforming growth factor beta1-type II receptor-type I receptor complex
ontology: CC
definition:
A protein complex that is formed by the association of a ligand-bound TGF-beta type II receptor dimer with a TGF-beta type I receptor dimer.


go_id: GO:0070023
term: interleukin-12-interleukin-12 receptor complex
ontology: CC
definition:
A protein complex that is formed by the association of a heterodimeric interleukin-12 receptor complex with an interleukin-12 heterodimer.


go_id: GO:0070024
term: CD19-Vav-PIK3R1 complex
ontology: CC
definition:
A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K).


go_id: GO:0070027
term: carbon monoxide sensor activity
ontology: MF
definition:
Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of carbon monoxide (CO).


go_id: GO:0070028
term: regulation of transcription by carbon monoxide
ontology: BP
definition:
Any process involving carbon monoxide that modulates the frequency, rate or extent of transcription.


go_id: GO:0070032
term: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
ontology: CC
definition:
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).


go_id: GO:0070033
term: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
ontology: CC
definition:
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof).


go_id: GO:0070034
term: telomeric RNA binding
ontology: MF
definition:
Interacting selectively and non-covalently with the telomerase RNA template or to RNA complementary to it.


go_id: GO:0070035
term: purine NTP-dependent helicase activity
ontology: MF
definition:
Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix.


go_id: GO:0070036
term: GTP-dependent helicase activity
ontology: MF
definition:
Catalysis of the reaction: GTP + H2O = GDP + phosphate, to drive the unwinding of a DNA or RNA helix.


go_id: GO:0070037
term: rRNA (pseudouridine) methyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule.


go_id: GO:0070038
term: rRNA (pseudouridine-N3-)-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine.


go_id: GO:0070039
term: rRNA (guanosine-2'-O-)-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine.


go_id: GO:0070040
term: rRNA (adenine-C2-)-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA.


go_id: GO:0070041
term: rRNA (uridine-C5-)-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine.


go_id: GO:0070042
term: rRNA (uridine-N3-)-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine.


go_id: GO:0070043
term: rRNA (guanine-N7-)-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine.


go_id: GO:0070044
term: synaptobrevin 2-SNAP-25-syntaxin-1a complex
ontology: CC
definition:
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof).


go_id: GO:0070045
term: synaptobrevin 2-SNAP-25-syntaxin-2 complex
ontology: CC
definition:
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof).


go_id: GO:0070046
term: synaptobrevin 2-SNAP-25-syntaxin-3 complex
ontology: CC
definition:
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof).


go_id: GO:0070047
term: synaptobrevin 2-SNAP-25-syntaxin-4 complex
ontology: CC
definition:
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof).


go_id: GO:0070050
term: neuron cellular homeostasis
ontology: BP
definition:
The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.


go_id: GO:0070051
term: fibrinogen binding
ontology: MF
definition:
Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade.


go_id: GO:0070054
term: mRNA splicing, via endonucleolytic cleavage and ligation
ontology: BP
definition:
Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.


go_id: GO:0070055
term: mRNA endonucleolytic cleavage involved in unfolded protein response
ontology: BP
definition:
The endonucleolytic cleavage of a mRNA containing an HAC1-type intron at the 5' and 3' splice sites. The cleavage step is part of unconventional mRNA splicing, and contributes to the endoplasmic reticulum unfolded protein response.


go_id: GO:0070056
term: prospore membrane leading edge
ontology: CC
definition:
The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization.


go_id: GO:0070057
term: prospore membrane spindle pole body attachment site
ontology: CC
definition:
The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus.


go_id: GO:0070058
term: tRNA gene clustering
ontology: BP
definition:
The process in which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae.


go_id: GO:0070059
term: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
ontology: BP
definition:
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.


go_id: GO:0070060
term: 'de novo' actin filament nucleation
ontology: BP
definition:
The actin nucleation process in which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament.


go_id: GO:0070061
term: fructose binding
ontology: MF
definition:
Interacting selectively and non-covalently with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose.


go_id: GO:0070062
term: extracellular exosome
ontology: CC
definition:
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.


go_id: GO:0070064
term: proline-rich region binding
ontology: MF
definition:
Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.


go_id: GO:0070066
term: cellubrevin-VAMP4-endobrevin-syntaxin-6 complex
ontology: CC
definition:
A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof).


go_id: GO:0070069
term: cytochrome complex
ontology: CC
definition:
A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions.


go_id: GO:0070070
term: proton-transporting V-type ATPase complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient.


go_id: GO:0070071
term: proton-transporting two-sector ATPase complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane.


go_id: GO:0070072
term: vacuolar proton-transporting V-type ATPase complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane.


go_id: GO:0070074
term: mononeme
ontology: CC
definition:
A secretory organelle that forms part of the apical complex; a small, threadlike structure located is close proximity to the subpellicular microtubules. Its contents include a rhomboid protease (PfROM1 in Plasmodium falciparum) that moves from the lateral asymmetric localization to the merozoite apical pole and the posterior pole upon release of merozoites from schizonts.


go_id: GO:0070075
term: tear secretion
ontology: BP
definition:
The regulated release of the aqueous layer of the tear film from the lacrimal glands. Tears are the liquid product of a process of lacrimation to clean and lubricate the eyes. Tear fluid contains water, mucin, lipids, lysozyme, lactoferrin, lipocalin, lacritin, immunoglobulins, glucose, urea, sodium, and potassium.


go_id: GO:0070078
term: histone H3-R2 demethylation
ontology: BP
definition:
The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone.


go_id: GO:0070079
term: histone H4-R3 demethylation
ontology: BP
definition:
The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone.


go_id: GO:0070080
term: titin Z domain binding
ontology: MF
definition:
Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34.


go_id: GO:0070081
term: clathrin-sculpted monoamine transport vesicle
ontology: CC
definition:
A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines.


go_id: GO:0070086
term: ubiquitin-dependent endocytosis
ontology: BP
definition:
Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded.


go_id: GO:0070087
term: chromo shadow domain binding
ontology: MF
definition:
Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain.


go_id: GO:0070088
term: PHA granule
ontology: CC
definition:
An inclusion body located in the cytoplasm that consists of polyhydroxyalkanoate (PHA) molecules and associated proteins, surrounded by a phospholipid monolayer; the proteins include PHA synthase, PHA depolymerase and 3HB-oligomer hydroxylase, phasins (PhaPs), which are thought to be the major structural proteins of the membrane surrounding the inclusion, and the regulator of phasin expression PhaR.


go_id: GO:0070089
term: chloride-activated potassium channel activity
ontology: MF
definition:
Enables the chloride concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient.


go_id: GO:0070090
term: metaphase plate
ontology: CC
definition:
The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division.


go_id: GO:0070091
term: glucagon secretion
ontology: BP
definition:
The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans).


go_id: GO:0070093
term: negative regulation of glucagon secretion
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.


go_id: GO:0070094
term: positive regulation of glucagon secretion
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.


go_id: GO:0070096
term: mitochondrial outer membrane translocase complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex.


go_id: GO:0070098
term: chemokine-mediated signaling pathway
ontology: BP
definition:
A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0070099
term: regulation of chemokine-mediated signaling pathway
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor.


go_id: GO:0070100
term: negative regulation of chemokine-mediated signaling pathway
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor.


go_id: GO:0070101
term: positive regulation of chemokine-mediated signaling pathway
ontology: BP
definition:
Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor.


go_id: GO:0070102
term: interleukin-6-mediated signaling pathway
ontology: BP
definition:
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0070103
term: regulation of interleukin-6-mediated signaling pathway
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6-mediated binding to a cell surface receptor.


go_id: GO:0070104
term: negative regulation of interleukin-6-mediated signaling pathway
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor.


go_id: GO:0070105
term: positive regulation of interleukin-6-mediated signaling pathway
ontology: BP
definition:
Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor.


go_id: GO:0070106
term: interleukin-27-mediated signaling pathway
ontology: BP
definition:
A series of molecular signals initiated by the binding of interleukin-27 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0070107
term: regulation of interleukin-27-mediated signaling pathway
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27-mediated binding to a cell surface receptor.


go_id: GO:0070108
term: negative regulation of interleukin-27-mediated signaling pathway
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor.


go_id: GO:0070109
term: positive regulation of interleukin-27-mediated signaling pathway
ontology: BP
definition:
Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor.


go_id: GO:0070110
term: ciliary neurotrophic factor receptor complex
ontology: CC
definition:
A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR.


go_id: GO:0070111
term: organellar chromatophore
ontology: CC
definition:
A bacteroid-containing symbiosome in which the bacterial component is a genetically highly reduced cyanobacterium that is photosynthetically active and incapable of an independent existence outside its host. The chromatophore functions as a photosynthetic organelle, and has been found and characterized in the amoeba Paulinella chromatophora.


go_id: GO:0070114
term: organellar chromatophore outer membrane
ontology: CC
definition:
The outer, i.e. cytoplasm-facing, of the two lipid bilayers surrounding an organellar chromatophore.


go_id: GO:0070120
term: ciliary neurotrophic factor-mediated signaling pathway
ontology: BP
definition:
A series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0070121
term: Kupffer's vesicle development
ontology: BP
definition:
The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.


go_id: GO:0070122
term: isopeptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of an isopeptide bond. An isopeptide bond is an amide linkage between a carboxyl group of one amino acid and an amino group of another amino acid in which at least one of these groups is not on the a-carbon of one of the amino acids (for example, the link between an epsilon-amino group of a lysine molecule to a carboxyl group on a second amino acid is an isopeptide bond).


go_id: GO:0070123
term: transforming growth factor beta receptor activity, type III
ontology: MF
definition:
Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors.


go_id: GO:0070124
term: mitochondrial translational initiation
ontology: BP
definition:
The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.


go_id: GO:0070125
term: mitochondrial translational elongation
ontology: BP
definition:
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion.


go_id: GO:0070126
term: mitochondrial translational termination
ontology: BP
definition:
The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa).


go_id: GO:0070127
term: tRNA aminoacylation for mitochondrial protein translation
ontology: BP
definition:
The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion.


go_id: GO:0070129
term: regulation of mitochondrial translation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.


go_id: GO:0070130
term: negative regulation of mitochondrial translation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.


go_id: GO:0070131
term: positive regulation of mitochondrial translation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion.


go_id: GO:0070132
term: regulation of mitochondrial translational initiation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.


go_id: GO:0070133
term: negative regulation of mitochondrial translational initiation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.


go_id: GO:0070134
term: positive regulation of mitochondrial translational initiation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.


go_id: GO:0070135
term: beta-1,2-oligomannoside metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan.


go_id: GO:0070136
term: beta-1,2-oligomannoside biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan.


go_id: GO:0070137
term: ubiquitin-like protein-specific endopeptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO).


go_id: GO:0070138
term: ubiquitin-like protein-specific isopeptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of an isopeptide bond between a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO) and a protein to which the small protein has been conjugated.


go_id: GO:0070139
term: SUMO-specific endopeptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO.


go_id: GO:0070140
term: SUMO-specific isopeptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of an isopeptide bond between the small conjugating protein SUMO and a protein to which SUMO has been conjugated.


go_id: GO:0070141
term: response to UV-A
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm.


go_id: GO:0070143
term: mitochondrial alanyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070144
term: mitochondrial arginyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling arginine to arginyl-tRNA in a mitochondrion, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070145
term: mitochondrial asparaginyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070146
term: mitochondrial aspartyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling aspartate to aspartyl-tRNA in a mitochondrion, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070147
term: mitochondrial cysteinyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070148
term: mitochondrial glutaminyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling glutamine to glutaminyl-tRNA in a mitochondrion, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070149
term: mitochondrial glutamyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling glutamate to glutamyl-tRNA in a mitochondrion, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070150
term: mitochondrial glycyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070151
term: mitochondrial histidyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling histidine to histidyl-tRNA in a mitochondrion, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070152
term: mitochondrial isoleucyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling isoleucine to isoleucyl-tRNA in a mitochondrion, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070153
term: mitochondrial leucyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling leucine to leucyl-tRNA in a mitochondrion, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070154
term: mitochondrial lysyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070155
term: mitochondrial methionyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling methionine to methionyl-tRNA in a mitochondrion, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070156
term: mitochondrial phenylalanyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling phenylalanine to phenylalanyl-tRNA in a mitochondrion, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070157
term: mitochondrial prolyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling proline to prolyl-tRNA in a mitochondrion, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070158
term: mitochondrial seryl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070159
term: mitochondrial threonyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070160
term: occluding junction
ontology: CC
definition:
A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.


go_id: GO:0070161
term: anchoring junction
ontology: CC
definition:
A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.


go_id: GO:0070163
term: regulation of adiponectin secretion
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the regulated release of adiponectin from a cell.


go_id: GO:0070164
term: negative regulation of adiponectin secretion
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell.


go_id: GO:0070165
term: positive regulation of adiponectin secretion
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell.


go_id: GO:0070166
term: enamel mineralization
ontology: BP
definition:
The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel.


go_id: GO:0070167
term: regulation of biomineral tissue development
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.


go_id: GO:0070168
term: negative regulation of biomineral tissue development
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.


go_id: GO:0070169
term: positive regulation of biomineral tissue development
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.


go_id: GO:0070170
term: regulation of tooth mineralization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures.


go_id: GO:0070171
term: negative regulation of tooth mineralization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures.


go_id: GO:0070172
term: positive regulation of tooth mineralization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures.


go_id: GO:0070173
term: regulation of enamel mineralization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel.


go_id: GO:0070174
term: negative regulation of enamel mineralization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel.


go_id: GO:0070175
term: positive regulation of enamel mineralization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel.


go_id: GO:0070176
term: DRM complex
ontology: CC
definition:
A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification.


go_id: GO:0070177
term: contractile vacuole discharge
ontology: BP
definition:
The regulated release of water from a contractile vacuole to the outside of a cell by fusion of the contractile vacuole membrane with the plasma membrane.


go_id: GO:0070178
term: D-serine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid.


go_id: GO:0070179
term: D-serine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine.


go_id: GO:0070180
term: large ribosomal subunit rRNA binding
ontology: MF
definition:
Interacting selectively and non-covalently with the large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA.


go_id: GO:0070181
term: small ribosomal subunit rRNA binding
ontology: MF
definition:
Interacting selectively and non-covalently with the small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA.


go_id: GO:0070183
term: mitochondrial tryptophanyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070184
term: mitochondrial tyrosyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling threonine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070185
term: mitochondrial valyl-tRNA aminoacylation
ontology: BP
definition:
The process of coupling valine to valyl-tRNA in a mitochondrion, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.


go_id: GO:0070186
term: growth hormone activity
ontology: MF
definition:
The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth.


go_id: GO:0070187
term: telosome
ontology: CC
definition:
A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex contains TRF1, TRF2, POT1, RAP1, TIN2 and TPP1 in mammalian cells, and Pot1, Tpz1, Ccq1, Poz1, Rap1, Rif1, Rif2and Rap1 in Schizosaccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1.


go_id: GO:0070188
term: Stn1-Ten1 complex
ontology: CC
definition:
A nuclear telomere cap complex that is formed by the association of the Stn1 and Ten1 proteins with telomeric DNA; in some species a third protein is present.


go_id: GO:0070189
term: kynurenine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine.


go_id: GO:0070191
term: methionine-R-sulfoxide reductase activity
ontology: MF
definition:
Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on free oxidized methionine with specificity for the R enantiomer; does not act on oxidized methionine in peptide linkage. Thioredoxin disulfide is the oxidized form of thioredoxin.


go_id: GO:0070193
term: synaptonemal complex organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis.


go_id: GO:0070196
term: eukaryotic translation initiation factor 3 complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 3 complex.


go_id: GO:0070197
term: attachment of telomere to nuclear envelope
ontology: BP
definition:
The cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation.


go_id: GO:0070198
term: protein localization to chromosome, telomeric region
ontology: BP
definition:
Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome.


go_id: GO:0070201
term: regulation of establishment of protein localization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.


go_id: GO:0070202
term: regulation of establishment of protein localization to chromosome
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome.


go_id: GO:0070203
term: regulation of establishment of protein localization to telomere
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the telomeric region of a chromosome.


go_id: GO:0070206
term: protein trimerization
ontology: BP
definition:
The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits.


go_id: GO:0070207
term: protein homotrimerization
ontology: BP
definition:
The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.


go_id: GO:0070208
term: protein heterotrimerization
ontology: BP
definition:
The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical.


go_id: GO:0070209
term: ASTRA complex
ontology: CC
definition:
A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p.


go_id: GO:0070210
term: Rpd3L-Expanded complex
ontology: CC
definition:
A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins.


go_id: GO:0070211
term: Snt2C complex
ontology: CC
definition:
A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p.


go_id: GO:0070212
term: protein poly-ADP-ribosylation
ontology: BP
definition:
The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain.


go_id: GO:0070213
term: protein auto-ADP-ribosylation
ontology: BP
definition:
The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.


go_id: GO:0070214
term: CSK-GAP-A.p62 complex
ontology: CC
definition:
A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation.


go_id: GO:0097371
term: MDM2/MDM4 family protein binding
ontology: MF
definition:
Interacting selectively and non-covalently with any isoform of the MDM2/MDM4 protein family, comprising negative regulators of p53.


go_id: GO:0070217
term: transcription factor TFIIIB complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a transcription factor TFIIIB complex.


go_id: GO:0070218
term: sulfide ion homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of sulfide ions within an organism or cell.


go_id: GO:0070219
term: cellular sulfide ion homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of sulfide ions at the level of a cell.


go_id: GO:0070220
term: aerobic sulfur oxidation
ontology: BP
definition:
A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase, and requires the presence of oxygen.


go_id: GO:0070221
term: sulfide oxidation, using sulfide:quinone oxidoreductase
ontology: BP
definition:
A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase.


go_id: GO:0070227
term: lymphocyte apoptotic process
ontology: BP
definition:
Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.


go_id: GO:0070229
term: negative regulation of lymphocyte apoptotic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process.


go_id: GO:0070230
term: positive regulation of lymphocyte apoptotic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process.


go_id: GO:0070231
term: T cell apoptotic process
ontology: BP
definition:
Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.


go_id: GO:0070233
term: negative regulation of T cell apoptotic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process.


go_id: GO:0070234
term: positive regulation of T cell apoptotic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process.


go_id: GO:0070236
term: negative regulation of activation-induced cell death of T cells
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells.


go_id: GO:0070237
term: positive regulation of activation-induced cell death of T cells
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of activation-induced cell death of T cells.


go_id: GO:0070238
term: activated T cell autonomous cell death
ontology: BP
definition:
A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen via the accumulation of pro-apoptotic gene products and decrease in anti-apoptotic gene products.


go_id: GO:0070240
term: negative regulation of activated T cell autonomous cell death
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of activated T cell autonomous cell death.


go_id: GO:0070241
term: positive regulation of activated T cell autonomous cell death
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of activated T cell autonomous cell death.


go_id: GO:0070244
term: negative regulation of thymocyte apoptotic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of thymocyte death by apoptotic process.


go_id: GO:0070245
term: positive regulation of thymocyte apoptotic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptotic process.


go_id: GO:0070246
term: natural killer cell apoptotic process
ontology: BP
definition:
Any apoptotic process in a natural killer cell, a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation.


go_id: GO:0070247
term: regulation of natural killer cell apoptotic process
ontology: BP
definition:
Any process that modulates the occurrence or rate of natural killer cell death by apoptotic process.


go_id: GO:0070248
term: negative regulation of natural killer cell apoptotic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell death by apoptotic process.


go_id: GO:0070249
term: positive regulation of natural killer cell apoptotic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of natural killer cell death by apoptotic process.


go_id: GO:0070250
term: mating projection membrane
ontology: CC
definition:
The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone.


go_id: GO:0070252
term: actin-mediated cell contraction
ontology: BP
definition:
The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.


go_id: GO:0070254
term: mucus secretion
ontology: BP
definition:
The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function.


go_id: GO:0070255
term: regulation of mucus secretion
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.


go_id: GO:0070256
term: negative regulation of mucus secretion
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.


go_id: GO:0070257
term: positive regulation of mucus secretion
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.


go_id: GO:0070258
term: inner membrane complex
ontology: CC
definition:
A membrane structure formed of two closely aligned lipid bilayers that lie beneath the plasma membrane and form part of the pellicle surrounding an apicomplexan parasite cell.


go_id: GO:0070259
term: tyrosyl-DNA phosphodiesterase activity
ontology: MF
definition:
Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA.


go_id: GO:0070260
term: 5'-tyrosyl-DNA phosphodiesterase activity
ontology: MF
definition:
Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA.


go_id: GO:0070263
term: external side of fungal-type cell wall
ontology: CC
definition:
The side of the fungal-type cell wall that is opposite to the side that faces the cell and its contents.


go_id: GO:0070264
term: transcription factor TFIIIE complex
ontology: CC
definition:
A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins.


go_id: GO:0070266
term: necroptotic process
ontology: BP
definition:
A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.


go_id: GO:0070267
term: oncosis
ontology: BP
definition:
A cellular process that results in swelling of the cell body, and that is morphologically characteristic of necrotic cell death.


go_id: GO:0070268
term: cornification
ontology: BP
definition:
A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability).


go_id: GO:0070269
term: pyroptosis
ontology: BP
definition:
A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.


go_id: GO:0070271
term: protein complex biogenesis
ontology: BP
definition:
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex.


go_id: GO:0070272
term: proton-transporting ATP synthase complex biogenesis
ontology: BP
definition:
The biogenesis of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together.


go_id: GO:0070273
term: phosphatidylinositol-4-phosphate binding
ontology: MF
definition:
Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.


go_id: GO:0070274
term: RES complex
ontology: CC
definition:
A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p.


go_id: GO:0070275
term: aerobic ammonia oxidation to nitrite via pyruvic oxime
ontology: BP
definition:
The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen. Hydroxylamine is produced enzymatically, and, in the presence of pyruvate, forms pyruvic oxime in a spontaneous, non-enzymatic reaction; pyruvic oxime is then converted to nitrite.


go_id: GO:0070276
term: halogen metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds.


go_id: GO:0070277
term: iodide oxidation
ontology: BP
definition:
The chemical reactions and pathways by which iodide is converted to diiodine, with the concomitant loss of electrons.


go_id: GO:0070278
term: extracellular matrix constituent secretion
ontology: BP
definition:
The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell.


go_id: GO:0070279
term: vitamin B6 binding
ontology: MF
definition:
Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.


go_id: GO:0070280
term: pyridoxal binding
ontology: MF
definition:
Interacting selectively and non-covalently with pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6.


go_id: GO:0070281
term: pyridoxamine binding
ontology: MF
definition:
Interacting selectively and non-covalently with pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6.


go_id: GO:0070282
term: pyridoxine binding
ontology: MF
definition:
Interacting selectively and non-covalently with pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6.


go_id: GO:0070283
term: radical SAM enzyme activity
ontology: MF
definition:
Catalysis of a reaction in which S-adenosyl-L-methionine (SAM) undergoes reductive cleavage to serve as a source of the 5'-deoxyadenosyl radical.


go_id: GO:0070284
term: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity
ontology: MF
definition:
Catalysis of the reaction: 5-aminoimidazole ribonucleotide + S-adenosylmethionine = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'deoxyadenosine.


go_id: GO:0070285
term: pigment cell development
ontology: BP
definition:
The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate.


go_id: GO:0070286
term: axonemal dynein complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.


go_id: GO:0070288
term: ferritin complex
ontology: CC
definition:
A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain.


go_id: GO:0070289
term: extracellular ferritin complex
ontology: CC
definition:
A ferritin complex located in the extracellular region. Extracellular ferritin complexes contain L (light) chains but few or no H (heavy) chains.


go_id: GO:0070290
term: N-acylphosphatidylethanolamine-specific phospholipase D activity
ontology: MF
definition:
Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE).


go_id: GO:0070291
term: N-acylethanolamine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group.


go_id: GO:0070292
term: N-acylphosphatidylethanolamine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group.


go_id: GO:0070293
term: renal absorption
ontology: BP
definition:
A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686).


go_id: GO:0070294
term: renal sodium ion absorption
ontology: BP
definition:
A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.


go_id: GO:0070295
term: renal water absorption
ontology: BP
definition:
A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.


go_id: GO:0070297
term: regulation of phosphorelay signal transduction system
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system.


go_id: GO:0070298
term: negative regulation of phosphorelay signal transduction system
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system.


go_id: GO:0070299
term: positive regulation of phosphorelay signal transduction system
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system.


go_id: GO:0070300
term: phosphatidic acid binding
ontology: MF
definition:
Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.


go_id: GO:0070301
term: cellular response to hydrogen peroxide
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.


go_id: GO:0070302
term: regulation of stress-activated protein kinase signaling cascade
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade.


go_id: GO:0070303
term: negative regulation of stress-activated protein kinase signaling cascade
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.


go_id: GO:0070304
term: positive regulation of stress-activated protein kinase signaling cascade
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade.


go_id: GO:0070305
term: response to cGMP
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus.


go_id: GO:0070306
term: lens fiber cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities.


go_id: GO:0070307
term: lens fiber cell development
ontology: BP
definition:
The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.


go_id: GO:0070308
term: lens fiber cell fate commitment
ontology: BP
definition:
The process in which the developmental fate of a cell becomes restricted such that it will develop into a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.


go_id: GO:0070309
term: lens fiber cell morphogenesis
ontology: BP
definition:
The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.


go_id: GO:0070310
term: ATR-ATRIP complex
ontology: CC
definition:
A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A.


go_id: GO:0070311
term: nucleosomal methylation activator complex
ontology: CC
definition:
A protein complex that contains eight subunits in common with the SWI/SNF complex, plus the ATPase BRG1 (SMARCA4) and the histone methyltransferase CARM1; the complex is involved in regulating nuclear receptor-dependent transcription.


go_id: GO:0070312
term: RAD52-ERCC4-ERCC1 complex
ontology: CC
definition:
A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein.


go_id: GO:0070313
term: RGS6-DNMT1-DMAP1 complex
ontology: CC
definition:
A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1.


go_id: GO:0070314
term: G1 to G0 transition
ontology: BP
definition:
A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence.


go_id: GO:0070315
term: G1 to G0 transition involved in cell differentiation
ontology: BP
definition:
A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters G0 phase, in the context of cell differentiation.


go_id: GO:0070316
term: regulation of G0 to G1 transition
ontology: BP
definition:
A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase.


go_id: GO:0070317
term: negative regulation of G0 to G1 transition
ontology: BP
definition:
A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.


go_id: GO:0070318
term: positive regulation of G0 to G1 transition
ontology: BP
definition:
A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase.


go_id: GO:0070319
term: Golgi to plasma membrane transport vesicle
ontology: CC
definition:
A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.


go_id: GO:0070321
term: regulation of translation in response to nitrogen starvation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen.


go_id: GO:0070322
term: negative regulation of translation in response to nitrogen starvation
ontology: BP
definition:
Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating deprivation of nitrogen.


go_id: GO:0070323
term: positive regulation of translation in response to nitrogen starvation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen.


go_id: GO:0070324
term: thyroid hormone binding
ontology: MF
definition:
Interacting selectively and non-covalently with thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland.


go_id: GO:0070327
term: thyroid hormone transport
ontology: BP
definition:
The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0070328
term: triglyceride homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell.


go_id: GO:0070331
term: CD20-Lck-Fyn complex
ontology: CC
definition:
A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck and Fyn.


go_id: GO:0070332
term: CD20-Lck-Lyn-Fyn complex
ontology: CC
definition:
A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck, Lyn and Fyn.


go_id: GO:0070333
term: alpha6-beta4 integrin-Shc-Grb2 complex
ontology: CC
definition:
A protein complex that consists of an alpha6-beta4 integrin complex bound to the adaptor proteins Shc and Grb2.


go_id: GO:0070335
term: aspartate binding
ontology: MF
definition:
Interacting selectively and non-covalently with aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4.


go_id: GO:0070336
term: flap-structured DNA binding
ontology: MF
definition:
Interacting selectively and non-covalently with a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule.


go_id: GO:0070337
term: 3'-flap-structured DNA binding
ontology: MF
definition:
Interacting selectively and non-covalently with a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule.


go_id: GO:0070338
term: 5'-flap-structured DNA binding
ontology: MF
definition:
Interacting selectively and non-covalently with a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers.


go_id: GO:0070339
term: response to bacterial lipopeptide
ontology: BP
definition:
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus.


go_id: GO:0070340
term: detection of bacterial lipopeptide
ontology: BP
definition:
The series of events in which a bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal.


go_id: GO:0070341
term: fat cell proliferation
ontology: BP
definition:
The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat.


go_id: GO:0070342
term: brown fat cell proliferation
ontology: BP
definition:
The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species.


go_id: GO:0070343
term: white fat cell proliferation
ontology: BP
definition:
The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population.


go_id: GO:0070353
term: GATA1-TAL1-TCF3-Lmo2 complex
ontology: CC
definition:
A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis.


go_id: GO:0070354
term: GATA2-TAL1-TCF3-Lmo2 complex
ontology: CC
definition:
A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis.


go_id: GO:0070355
term: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex
ontology: CC
definition:
A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, Rab3a, and complexin II (or orthologs thereof).


go_id: GO:0070356
term: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex
ontology: CC
definition:
A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Rab3a (or orthologs thereof).


go_id: GO:0070357
term: alphav-beta3 integrin-CD47 complex
ontology: CC
definition:
A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP).


go_id: GO:0070358
term: actin polymerization-dependent cell motility
ontology: BP
definition:
A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell.


go_id: GO:0070359
term: actin polymerization-dependent cell motility involved in migration of symbiont in host
ontology: BP
definition:
A process involved in the controlled movement of a bacterial cell within a host cell, powered by the continuous polymerization of host actin at one pole of the cell.


go_id: GO:0070360
term: migration of symbiont within host by polymerization of host actin
ontology: BP
definition:
The directional movement of an organism, usually a bacterial cell, from one place to another within its host organism, by a process involving continuous polymerization of host actin at one pole of the symbiont cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.


go_id: GO:0070361
term: mitochondrial light strand promoter anti-sense binding
ontology: MF
definition:
Interacting selectively and non-covalently with the anti-sense strand of the light strand promoter, a promoter located on the light, or cytosine-rich, strand of mitochondrial DNA.


go_id: GO:0070362
term: mitochondrial heavy strand promoter anti-sense binding
ontology: MF
definition:
Interacting selectively and non-covalently with the anti-sense strand of the heavy strand promoter, a promoter located on the heavy, or guanine-rich, strand of mitochondrial DNA.


go_id: GO:0070363
term: mitochondrial light strand promoter sense binding
ontology: MF
definition:
Interacting selectively and non-covalently with the sense strand of the light strand promoter, a promoter located on the light, or cytosine-rich, strand of mitochondrial DNA.


go_id: GO:0070364
term: mitochondrial heavy strand promoter sense binding
ontology: MF
definition:
Interacting selectively and non-covalently with the sense strand of the heavy strand promoter, a promoter located on the heavy, or guanine-rich, strand of mitochondrial DNA.


go_id: GO:0070365
term: hepatocyte differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver.


go_id: GO:0070369
term: beta-catenin-TCF7L2 complex
ontology: CC
definition:
A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription.


go_id: GO:0070371
term: ERK1 and ERK2 cascade
ontology: BP
definition:
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.


go_id: GO:0070372
term: regulation of ERK1 and ERK2 cascade
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.


go_id: GO:0070373
term: negative regulation of ERK1 and ERK2 cascade
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.


go_id: GO:0070374
term: positive regulation of ERK1 and ERK2 cascade
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.


go_id: GO:0070375
term: ERK5 cascade
ontology: BP
definition:
An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.


go_id: GO:0070376
term: regulation of ERK5 cascade
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.


go_id: GO:0070377
term: negative regulation of ERK5 cascade
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.


go_id: GO:0070378
term: positive regulation of ERK5 cascade
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK5 cascade.


go_id: GO:0070380
term: high mobility group box 1 receptor activity
ontology: MF
definition:
Combining with high mobility group box 1 (HMBGB1) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0070381
term: endosome to plasma membrane transport vesicle
ontology: CC
definition:
A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasmsa membrane  and to release various cargo molecules, such as proteins or hormones, by exocytosis.


go_id: GO:0070382
term: exocytic vesicle
ontology: CC
definition:
A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.


go_id: GO:0070384
term: Harderian gland development
ontology: BP
definition:
The process whose specific outcome is the progression of the Harderian gland over time, from its formation to the mature structure. The Harderian gland is an anterior orbital structure usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the species.


go_id: GO:0070385
term: egasyn-beta-glucuronidase complex
ontology: CC
definition:
A protein complex that contains beta-glucuronidase and the carboxyl esterase egasyn; formation of the complex causes beta-glucuronidase to be retained in the endoplasmic reticulum.


go_id: GO:0070386
term: procollagen-proline 4-dioxygenase complex, alpha(I) type
ontology: CC
definition:
A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type I isoform; its activity is readily inhibited by poly(L-proline).


go_id: GO:0070387
term: procollagen-proline 4-dioxygenase complex, alpha(II) type
ontology: CC
definition:
A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type II isoform; its activity is inhibited by poly(L-proline) only at high concentrations.


go_id: GO:0070389
term: chaperone cofactor-dependent protein refolding
ontology: BP
definition:
The process of assisting in the restoration of the biological activity of an unfolded or misfolded protein, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.


go_id: GO:0070390
term: transcription export complex 2
ontology: CC
definition:
A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sus1p and Cdc31p.


go_id: GO:0070391
term: response to lipoteichoic acid
ontology: BP
definition:
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.


go_id: GO:0070392
term: detection of lipoteichoic acid
ontology: BP
definition:
The series of events in which a lipoteichoic acid stimulus is received by a cell and converted into a molecular signal; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.


go_id: GO:0070393
term: teichoic acid catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues.


go_id: GO:0070394
term: lipoteichoic acid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.


go_id: GO:0070395
term: lipoteichoic acid biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.


go_id: GO:0070396
term: lipoteichoic acid catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.


go_id: GO:0070397
term: wall teichoic acid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan.


go_id: GO:0070398
term: wall teichoic acid biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan.


go_id: GO:0070399
term: wall teichoic acid catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan.


go_id: GO:0070400
term: teichoic acid D-alanylation
ontology: BP
definition:
The formation of a D-alanyl ester of teichoic acid. Alanylation of teichoic acids modulates the properties of the bacterial cell wall and modulates the inflammatory properties of the teichoic acid.


go_id: GO:0070401
term: NADP+ binding
ontology: MF
definition:
Interacting selectively and non-covalently with the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.


go_id: GO:0070402
term: NADPH binding
ontology: MF
definition:
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.


go_id: GO:0070403
term: NAD+ binding
ontology: MF
definition:
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.


go_id: GO:0070404
term: NADH binding
ontology: MF
definition:
Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.


go_id: GO:0070407
term: oxidation-dependent protein catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein.


go_id: GO:0070408
term: carbamoyl phosphate metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways.


go_id: GO:0070409
term: carbamoyl phosphate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways.


go_id: GO:0070413
term: trehalose metabolism in response to stress
ontology: BP
definition:
The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress.


go_id: GO:0070414
term: trehalose metabolism in response to heat stress
ontology: BP
definition:
The chemical reactions and pathways involving trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.


go_id: GO:0070415
term: trehalose metabolism in response to cold stress
ontology: BP
definition:
The chemical reactions and pathways involving trehalose that occur as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.


go_id: GO:0070416
term: trehalose metabolism in response to water deprivation
ontology: BP
definition:
The chemical reactions and pathways involving trehalose that occur as a result of deprivation of water.


go_id: GO:0070417
term: cellular response to cold
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.


go_id: GO:0070418
term: DNA-dependent protein kinase complex
ontology: CC
definition:
A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku.


go_id: GO:0070419
term: nonhomologous end joining complex
ontology: CC
definition:
A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends.


go_id: GO:0070420
term: Ku-DNA ligase complex
ontology: CC
definition:
A nonhomologous end joining complex that contains one or more Ku monomers and one or more DNA ligase molecules from the LigC or LigD family, and mediates nonhomologous end joining in bacteria.


go_id: GO:0070422
term: G-protein beta/gamma-Raf-1 complex
ontology: CC
definition:
A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein.


go_id: GO:0070423
term: nucleotide-binding oligomerization domain containing signaling pathway
ontology: BP
definition:
Any series of molecular signals generated as a consequence of binding to a nucleotide-binding oligomerization domain containing (NOD) protein.


go_id: GO:0070424
term: regulation of nucleotide-binding oligomerization domain containing signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of a nucleotide-binding oligomerization domain containing (NOD) pathway.


go_id: GO:0070425
term: negative regulation of nucleotide-binding oligomerization domain containing signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway.


go_id: GO:0070426
term: positive regulation of nucleotide-binding oligomerization domain containing signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway.


go_id: GO:0070427
term: nucleotide-binding oligomerization domain containing 1 signaling pathway
ontology: BP
definition:
Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 1 (NOD1).


go_id: GO:0070428
term: regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway.


go_id: GO:0070429
term: negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway.


go_id: GO:0070430
term: positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway.


go_id: GO:0070431
term: nucleotide-binding oligomerization domain containing 2 signaling pathway
ontology: BP
definition:
Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 2 (NOD2).


go_id: GO:0070432
term: regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.


go_id: GO:0070433
term: negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.


go_id: GO:0070434
term: positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.


go_id: GO:0070435
term: Shc-EGFR complex
ontology: CC
definition:
A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway.


go_id: GO:0070436
term: Grb2-EGFR complex
ontology: CC
definition:
A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway.


go_id: GO:0070437
term: Grb2-Shc complex
ontology: CC
definition:
A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway.


go_id: GO:0070439
term: Mad-Max-mSin3A complex
ontology: CC
definition:
A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p.


go_id: GO:0070440
term: Mad-Max-mSin3B complex
ontology: CC
definition:
A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p.


go_id: GO:0070441
term: G-protein beta/gamma-Btk complex
ontology: CC
definition:
A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein.


go_id: GO:0070443
term: Mad-Max complex
ontology: CC
definition:
A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max.


go_id: GO:0070444
term: oligodendrocyte progenitor proliferation
ontology: BP
definition:
The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system.


go_id: GO:0070445
term: regulation of oligodendrocyte progenitor proliferation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation.


go_id: GO:0070447
term: positive regulation of oligodendrocyte progenitor proliferation
ontology: BP
definition:
Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation.


go_id: GO:0070448
term: laricitrin 5'-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin.


go_id: GO:0070449
term: elongin complex
ontology: CC
definition:
A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits.


go_id: GO:0070450
term: interleukin4-interleukin-4 receptor complex
ontology: CC
definition:
A protein complex that is formed by the association of a heterodimeric interleukin-4 receptor complex with an interleukin-4 molecule.


go_id: GO:0070451
term: cell hair
ontology: CC
definition:
A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located.


go_id: GO:0070452
term: positive regulation of ergosterol biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol.


go_id: GO:0070453
term: regulation of heme biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme.


go_id: GO:0070454
term: negative regulation of heme biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme.


go_id: GO:0070458
term: cellular detoxification of nitrogen compound
ontology: BP
definition:
Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances.


go_id: GO:0070459
term: prolactin secretion
ontology: BP
definition:
The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary.


go_id: GO:0070460
term: thyroid-stimulating hormone secretion
ontology: BP
definition:
The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary.


go_id: GO:0070461
term: SAGA-type complex
ontology: CC
definition:
A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.


go_id: GO:0070463
term: tubulin-dependent ATPase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate.


go_id: GO:0070464
term: alphav-beta3 integrin-collagen alpha3(VI) complex
ontology: CC
definition:
A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen.


go_id: GO:0070465
term: alpha1-beta1 integrin-alpha3(VI) complex
ontology: CC
definition:
A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.


go_id: GO:0070466
term: alpha2-beta1 integrin-alpha3(VI) complex
ontology: CC
definition:
A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain.


go_id: GO:0070467
term: RC-1 DNA recombination complex
ontology: CC
definition:
A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA.


go_id: GO:0070468
term: dentin secretion
ontology: BP
definition:
The regulated release by odontoblasts of the extracellular matrix constituents, including collagen, that form the basis of dentin.


go_id: GO:0070469
term: respiratory chain
ontology: CC
definition:
The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.


go_id: GO:0070470
term: plasma membrane respiratory chain
ontology: CC
definition:
A respiratory chain located in the plasma membrane of a cell; made up of the protein complexes that form the electron transport system (the respiratory chain), associated with the plasma membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.


go_id: GO:0070471
term: uterine smooth muscle contraction
ontology: BP
definition:
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the uterus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The uterus is a muscular organ of the female mammal for containing and usually for nourishing the young during development prior to birth.


go_id: GO:0070475
term: rRNA base methylation
ontology: BP
definition:
The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.


go_id: GO:0070476
term: rRNA (guanine-N7)-methylation
ontology: BP
definition:
The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule.


go_id: GO:0070477
term: endospore core
ontology: CC
definition:
An intracellular part that represents the innermost portion of an endospore; the endospore core is dehydrated, enriched in dipicolinic acid and divalent cations, and metabolically inactive.


go_id: GO:0070478
term: nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.


go_id: GO:0070479
term: nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction.


go_id: GO:0070480
ontology: BP
term:
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay

definition:
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap.


go_id: GO:0070481
term: nuclear-transcribed mRNA catabolic process, non-stop decay
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon.


go_id: GO:0070482
term: response to oxygen levels
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.


go_id: GO:0070483
term: detection of hypoxia
ontology: BP
definition:
The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.


go_id: GO:0070484
term: dehydro-D-arabinono-1,4-lactone metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one.


go_id: GO:0070485
term: dehydro-D-arabinono-1,4-lactone biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one.


go_id: GO:0070490
term: protein pupylation
ontology: BP
definition:
The process in which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of Pup and the epsilon-amino group of a lysine residue of the target protein.


go_id: GO:0070491
term: repressing transcription factor binding
ontology: MF
definition:
Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription.


go_id: GO:0070492
term: oligosaccharide binding
ontology: MF
definition:
Interacting selectively and non-covalently with any oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.


go_id: GO:0070493
term: thrombin receptor signaling pathway
ontology: BP
definition:
The series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands.


go_id: GO:0070494
term: regulation of thrombin receptor signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a thrombin receptor signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands.


go_id: GO:0070495
term: negative regulation of thrombin receptor signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands.


go_id: GO:0070496
term: positive regulation of thrombin receptor signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of thrombin receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands.


go_id: GO:0070497
term: 6-carboxy-5,6,7,8-tetrahydropterin synthase activity
ontology: MF
definition:
Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+.


go_id: GO:0070498
term: interleukin-1-mediated signaling pathway
ontology: BP
definition:
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0070499
term: exosporium assembly
ontology: BP
definition:
A process that is carried out at the cellular level which results in the formation of an exosporium, the outermost layer of a bacterial endospore.


go_id: GO:0070500
term: poly-gamma-glutamate metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds.


go_id: GO:0070501
term: poly-gamma-glutamate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds.


go_id: GO:0070502
term: capsule poly-gamma-glutamate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds, that forms all or part of a bacterial capsule.


go_id: GO:0070503
term: selenium-containing prosthetic group metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments.


go_id: GO:0070504
term: selenium-containing prosthetic group biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments.


go_id: GO:0070505
term: pollen coat
ontology: CC
definition:
A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma.


go_id: GO:0070506
term: high-density lipoprotein particle receptor activity
ontology: MF
definition:
Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis.


go_id: GO:0070507
term: regulation of microtubule cytoskeleton organization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.


go_id: GO:0070510
term: regulation of histone H4-K20 methylation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4.


go_id: GO:0070511
term: negative regulation of histone H4-K20 methylation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4.


go_id: GO:0070512
term: positive regulation of histone H4-K20 methylation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4.


go_id: GO:0070513
term: death domain binding
ontology: MF
definition:
Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB.


go_id: GO:0070514
term: SRF-myogenin-E12 complex
ontology: CC
definition:
A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes.


go_id: GO:0070516
term: CAK-ERCC2 complex
ontology: CC
definition:
A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2.


go_id: GO:0070517
term: DNA replication factor C core complex
ontology: CC
definition:
A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37.


go_id: GO:0070518
term: alpha4-beta1 integrin-CD53 complex
ontology: CC
definition:
A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family.


go_id: GO:0070519
term: alpha4-beta1 integrin-CD63 complex
ontology: CC
definition:
A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family.


go_id: GO:0070520
term: alpha4-beta1 integrin-CD81 complex
ontology: CC
definition:
A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family.


go_id: GO:0070521
term: alpha4-beta1 integrin-CD82 complex
ontology: CC
definition:
A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD82, a member of the tetraspan family.


go_id: GO:0070522
term: ERCC4-ERCC1 complex
ontology: CC
definition:
A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae.


go_id: GO:0070525
term: tRNA threonylcarbamoyladenosine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.


go_id: GO:0070528
term: protein kinase C signaling
ontology: BP
definition:
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.


go_id: GO:0070530
term: K63-linked polyubiquitin binding
ontology: MF
definition:
Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers.


go_id: GO:0070531
term: BRCA1-A complex
ontology: CC
definition:
A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites.


go_id: GO:0070532
term: BRCA1-B complex
ontology: CC
definition:
A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites.


go_id: GO:0070533
term: BRCA1-C complex
ontology: CC
definition:
A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint.


go_id: GO:0070534
term: protein K63-linked ubiquitination
ontology: BP
definition:
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.


go_id: GO:0070535
term: histone H2A K63-linked ubiquitination
ontology: BP
definition:
A histone ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a lysine residue in histone H2A or the variant H2AX.


go_id: GO:0070536
term: protein K63-linked deubiquitination
ontology: BP
definition:
A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein.


go_id: GO:0070537
term: histone H2A K63-linked deubiquitination
ontology: BP
definition:
A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a lysine residue in histone H2A or the variant H2AX.


go_id: GO:0070538
term: oleic acid binding
ontology: MF
definition:
Interacting selectively and non-covalently with oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid.


go_id: GO:0070539
term: linoleic acid binding
ontology: MF
definition:
Interacting selectively and non-covalently with linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid.


go_id: GO:0070540
term: stearic acid binding
ontology: MF
definition:
Interacting selectively and non-covalently with stearic acid, the 18-carbon saturated fatty acid octadecanoic acid.


go_id: GO:0070541
term: response to platinum ion
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus.


go_id: GO:0070542
term: response to fatty acid
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.


go_id: GO:0070543
term: response to linoleic acid
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus.


go_id: GO:0070544
term: histone H3-K36 demethylation
ontology: BP
definition:
The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone.


go_id: GO:0070545
term: PeBoW complex
ontology: CC
definition:
A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively.


go_id: GO:0070546
term: L-phenylalanine aminotransferase activity
ontology: MF
definition:
Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid.


go_id: GO:0070549
term: negative regulation of translation involved in RNA interference
ontology: BP
definition:
A process of negative regulation of translation that is mediated by the association of small interfering RNAs (siRNAs) with a cognate target mRNA.


go_id: GO:0070550
term: rDNA condensation
ontology: BP
definition:
The process in which the chromatin structure of the rDNA repeats is compacted. In S. cerevisiae, condensation and resolution of the rDNA occurs during anaphase.


go_id: GO:0070551
term: endoribonuclease activity, cleaving siRNA-paired mRNA
ontology: MF
definition:
Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters.


go_id: GO:0070552
term: BRISC complex
ontology: CC
definition:
A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains.


go_id: GO:0070554
term: synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex
ontology: CC
definition:
A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof).


go_id: GO:0070555
term: response to interleukin-1
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.


go_id: GO:0070556
term: TAF4B-containing transcription factor TFIID complex
ontology: CC
definition:
A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4.


go_id: GO:0070557
term: PCNA-p21 complex
ontology: CC
definition:
A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication.


go_id: GO:0070558
term: alphaM-beta2 integrin-CD63 complex
ontology: CC
definition:
A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family.


go_id: GO:0070559
term: lysosomal multienzyme complex
ontology: CC
definition:
A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism.


go_id: GO:0070561
term: vitamin D receptor signaling pathway
ontology: BP
definition:
The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands.


go_id: GO:0070562
term: regulation of vitamin D receptor signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity.


go_id: GO:0070563
term: negative regulation of vitamin D receptor signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity.


go_id: GO:0070564
term: positive regulation of vitamin D receptor signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity.


go_id: GO:0070565
term: telomere-telomerase complex
ontology: CC
definition:
A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome.


go_id: GO:0070570
term: regulation of neuron projection regeneration
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage.


go_id: GO:0070571
term: negative regulation of neuron projection regeneration
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage.


go_id: GO:0070572
term: positive regulation of neuron projection regeneration
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage.


go_id: GO:0070573
term: metallodipeptidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.


go_id: GO:0070574
term: cadmium ion transmembrane transport
ontology: BP
definition:
A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.


go_id: GO:0070575
term: peptide mating pheromone maturation involved in pheromone-induced unidirectional conjugation
ontology: BP
definition:
The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of pheromone-induced unidirectional conjugation.


go_id: GO:0070577
term: lysine-acetylated histone binding
ontology: MF
definition:
Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation.


go_id: GO:0070578
term: RISC-loading complex
ontology: CC
definition:
A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP.  This complex has endorobonuclease activity.


go_id: GO:0070579
term: methylcytosine dioxygenase activity
ontology: MF
definition:
Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2.


go_id: GO:0070580
term: base J metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J.


go_id: GO:0070581
term: rolling circle DNA replication
ontology: BP
definition:
A DNA-dependent DNA replication process in which a single-stranded DNA molecule is synthesized from a circular duplex template. Replication typically does not cease when one circumference has been replicated, but continues around the circumference several more times, producing a long single strand comprising multimers of the replicon.


go_id: GO:0070582
term: theta DNA replication
ontology: BP
definition:
A DNA-dependent DNA replication process in which a double-stranded DNA molecule is synthesized from a circular duplex template.


go_id: GO:0070583
term: spore membrane bending pathway
ontology: BP
definition:
The process in which a bending force is generated in the prospore membrane to form the characteristic curved shape of the prospore.


go_id: GO:0070585
term: protein localization to mitochondrion
ontology: BP
definition:
A process in which a protein is transported to, or maintained in, a location within the mitochondrion.


go_id: GO:0070587
term: regulation of cell-cell adhesion involved in gastrulation
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation.


go_id: GO:0070588
term: calcium ion transmembrane transport
ontology: BP
definition:
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.


go_id: GO:0070589
term: cellular component macromolecule biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of a macromolecule that is destined to form part of a specific cellular component.


go_id: GO:0070590
term: spore wall biogenesis
ontology: BP
definition:
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a spore wall. A spore wall is the specialized cell wall lying outside the cell membrane of a spore.


go_id: GO:0070591
term: ascospore wall biogenesis
ontology: BP
definition:
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of an ascospore wall.


go_id: GO:0070592
term: cell wall polysaccharide biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of a polysaccharide destined to form part of a cell wall.


go_id: GO:0070593
term: dendrite self-avoidance
ontology: BP
definition:
The process in which dendrites recognize and avoid contact with sister dendrites from the same cell.


go_id: GO:0070594
term: juvenile hormone response element binding
ontology: MF
definition:
Interacting selectively and non-covalently with the juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone.


go_id: GO:0070595
term: (1->3)-alpha-glucan metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds.


go_id: GO:0070596
term: (1->3)-alpha-glucan biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds.


go_id: GO:0070597
term: cell wall (1->3)-alpha-glucan metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells.


go_id: GO:0070598
term: cell wall (1->3)-alpha-glucan biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-glucosidic bonds, found in the walls of cells.


go_id: GO:0070599
term: fungal-type cell wall (1->3)-alpha-glucan metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of ascospores.


go_id: GO:0070600
term: fungal-type cell wall (1->3)-alpha-glucan biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores.


go_id: GO:0070601
term: centromeric sister chromatid cohesion
ontology: BP
definition:
The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the centromeric region of the chromosome.


go_id: GO:0070602
term: regulation of centromeric sister chromatid cohesion
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome.


go_id: GO:0070603
term: SWI/SNF superfamily-type complex
ontology: CC
definition:
A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP.


go_id: GO:0070605
term: regulation of (1->3)-alpha-glucan metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds.


go_id: GO:0070606
term: regulation of (1->3)-alpha-glucan biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds.


go_id: GO:0070607
term: regulation of cell wall (1->3)-alpha-glucan metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells.


go_id: GO:0070608
term: regulation of cell wall (1->3)-alpha-glucan biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells.


go_id: GO:0070609
term: regulation of fungal-type cell wall (1->3)-alpha-glucan metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of ascospores.


go_id: GO:0070610
term: regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores.


go_id: GO:0070611
term: histone methyltransferase activity (H3-R2 specific)
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to arginine at position 2 of histone H3.


go_id: GO:0070612
term: histone methyltransferase activity (H2A-R3 specific)
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H2A.


go_id: GO:0070613
term: regulation of protein processing
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of protein processing, any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein.


go_id: GO:0070614
term: tungstate ion transport
ontology: BP
definition:
The directed movement of tungstate (WO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tungstate is a bivalent oxoanion of tungsten.


go_id: GO:0070615
term: nucleosome-dependent ATPase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of one or more nucleosomes.


go_id: GO:0070616
term: regulation of thiamine diphosphate biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate.


go_id: GO:0070617
term: negative regulation of thiamine diphosphate biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate.


go_id: GO:0070618
term: Grb2-Sos complex
ontology: CC
definition:
A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.


go_id: GO:0070619
term: Shc-Grb2-Sos complex
ontology: CC
definition:
A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.


go_id: GO:0070620
term: EGFR-Grb2-Sos complex
ontology: CC
definition:
A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.


go_id: GO:0070621
term: EGFR-Shc-Grb2-Sos complex
ontology: CC
definition:
A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2, the adaptor protein SHC and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.


go_id: GO:0070622
term: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
ontology: CC
definition:
A protein complex that possesses UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; the bovine complex contains disulfide-linked homodimers of 166- and 51-kDa subunits and two identical, noncovalently associated 56-kDa subunits.


go_id: GO:0070623
term: regulation of thiamine biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine.


go_id: GO:0070624
term: negative regulation of thiamine biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine.


go_id: GO:0070625
term: zymogen granule exocytosis
ontology: BP
definition:
The release of intracellular molecules contained within the zymogen granule by fusion of the granule with the plasma membrane of the oocyte, requiring calcium ions.


go_id: GO:0070626
ontology: MF
term:
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity

definition:
Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.


go_id: GO:0070627
term: ferrous iron import
ontology: BP
definition:
The directed movement of ferrous iron (Fe(II) or Fe2+) ions across a membrane into a cell or organelle.


go_id: GO:0070628
term: proteasome binding
ontology: MF
definition:
Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation.


go_id: GO:0070629
term: (1->4)-alpha-glucan metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds.


go_id: GO:0070630
term: (1->4)-alpha-glucan biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds.


go_id: GO:0070631
term: spindle pole body localization
ontology: BP
definition:
Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells.


go_id: GO:0070632
term: establishment of spindle pole body localization
ontology: BP
definition:
Any process in which a spindle pole body is transported to a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells.


go_id: GO:0070637
term: pyridine nucleoside metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose.


go_id: GO:0070638
term: pyridine nucleoside catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose.


go_id: GO:0070639
term: vitamin D2 metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving vitamin D2, (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol.


go_id: GO:0070640
term: vitamin D3 metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol.


go_id: GO:0070641
term: vitamin D4 metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving vitamin D4, (3S,5Z,7E)-9,10-secoergosta-5,7,10(19)-trien-3-ol.


go_id: GO:0070642
term: vitamin D5 metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving vitamin D5, (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,4S)-4-ethyl-1,5-dimethylhexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol.


go_id: GO:0070644
term: vitamin D response element binding
ontology: MF
definition:
Interacting selectively and non-covalently with the vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum.


go_id: GO:0070645
term: Ubisch body
ontology: CC
definition:
A small, granular structure that is found in the extracellular matrix of cell of the secretory tapetal layer that surrounds developing pollen grains. Ubisch bodies have a sporopollenin coat, are attached to the peritapetal wall, and may play a role in pollen development.


go_id: GO:0070646
term: protein modification by small protein removal
ontology: BP
definition:
A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein.


go_id: GO:0070647
term: protein modification by small protein conjugation or removal
ontology: BP
definition:
A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.


go_id: GO:0070648
term: formin-nucleated actin cable
ontology: CC
definition:
An actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. In fungal cells, myosin motors transport cargo along actin cables toward sites of polarized cell growth; actin cables may play a similar role in pollen tube growth.


go_id: GO:0070649
term: formin-nucleated actin cable assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.


go_id: GO:0070650
term: actin filament bundle distribution
ontology: BP
definition:
Any cellular process that establishes the spatial arrangement of actin filament bundles within the cell.


go_id: GO:0070651
term: nonfunctional rRNA decay
ontology: BP
definition:
An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system.


go_id: GO:0070652
term: HAUS complex
ontology: CC
definition:
A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex.


go_id: GO:0070664
term: negative regulation of leukocyte proliferation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.


go_id: GO:0070669
term: response to interleukin-2
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus.


go_id: GO:0070670
term: response to interleukin-4
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.


go_id: GO:0070671
term: response to interleukin-12
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus.


go_id: GO:0070672
term: response to interleukin-15
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus.


go_id: GO:0070673
term: response to interleukin-18
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus.


go_id: GO:0070677
term: rRNA (cytosine-2'-O-)-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine.


go_id: GO:0070678
term: preprotein binding
ontology: MF
definition:
Interacting selectively and non-covalently with a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing.


go_id: GO:0070680
term: asparaginyl-tRNAAsn biosynthesis via transamidation
ontology: BP
definition:
A tRNA aminoacylation process in which asparaginyl-tRNAAsn is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating aspartyl-tRNA synthetase generates the misacylated L-aspartyl-tRNAAsn species, and in the second step it is amidated to the correctly charged L-asparaginyl-tRNAAsn by the heterotrimeric aspartyl-tRNAAsn amidotransferase.


go_id: GO:0070681
term: glutaminyl-tRNAGln biosynthesis via transamidation
ontology: BP
definition:
A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase.


go_id: GO:0070682
term: proteasome regulatory particle assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex.


go_id: GO:0070684
term: seminal clot liquefaction
ontology: BP
definition:
The reproductive process in which coagulated semen becomes liquid following ejaculation, allowing the progressive release of motile spermatozoa.


go_id: GO:0070685
term: macropinocytic cup
ontology: CC
definition:
A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin.


go_id: GO:0070688
term: MLL5-L complex
ontology: CC
definition:
A protein complex that can methylate lysine-4 of histone H3 and plays an essential role in retinoic-acid-induced granulopoiesis. MLL5 is the catalytic methyltransferase subunit, and the complex also contains serine/threonine kinase 38 (STK38), protein phosphatase 1 catalytic subunits, the host cell factor-1 N-terminal subunit, beta-actin, and O-GlcNAc transferase; the human genes encoding the subunits are MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT, respectively.


go_id: GO:0070689
term: L-threonine catabolic process to propionate
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound propionate.


go_id: GO:0070690
term: L-threonine catabolic process to acetyl-CoA
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) into glycine and acetaldehyde, with acetaldehyde being subsequently converted to acetyl-CoA.


go_id: GO:0070691
term: dimeric positive transcription elongation factor complex b
ontology: CC
definition:
A positive transcription elongation factor complex b that comprises two subunits; an example is the budding yeast complex containing Svg1p (also called Bur1p) and Bur2p.


go_id: GO:0070692
term: trimeric positive transcription elongation factor complex b
ontology: CC
definition:
A positive transcription elongation factor complex b that comprises three subunits; an example is the budding yeast Ctk complex, which consists of Ctk1p, Ctk2p and Ctk3p.


go_id: GO:0070693
term: P-TEFb-cap methyltransferase complex
ontology: CC
definition:
A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping methyltransferase.


go_id: GO:0070694
term: deoxyribonucleoside 5'-monophosphate N-glycosidase activity
ontology: MF
definition:
Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base.


go_id: GO:0070695
term: FHF complex
ontology: CC
definition:
A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex).


go_id: GO:0070696
term: transmembrane receptor protein serine/threonine kinase binding
ontology: MF
definition:
Interacting selectively and non-covalently with a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity.


go_id: GO:0070701
term: mucus layer
ontology: CC
definition:
An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon or secreted into fluids such as saliva. Mucus is a viscous slimy secretion consisting of mucins (i.e. highly glycosylated mucin proteins) and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes.


go_id: GO:0070702
term: inner mucus layer
ontology: CC
definition:
The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria.


go_id: GO:0070703
term: outer mucus layer
ontology: CC
definition:
The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria.


go_id: GO:0070715
term: sodium-dependent organic cation transport
ontology: BP
definition:
The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0070716
term: mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
ontology: BP
definition:
A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication.


go_id: GO:0070717
term: poly-purine tract binding
ontology: MF
definition:
Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule.


go_id: GO:0070718
term: alphaPDGFR-SHP-2 complex
ontology: CC
definition:
A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.


go_id: GO:0070719
term: alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex
ontology: CC
definition:
A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway.


go_id: GO:0070720
term: Grb2-SHP-2 complex
ontology: CC
definition:
A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway.


go_id: GO:0070722
term: Tle3-Aes complex
ontology: CC
definition:
A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product.


go_id: GO:0070723
term: response to cholesterol
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.


go_id: GO:0070724
term: BMP receptor complex
ontology: CC
definition:
A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits.


go_id: GO:0070725
term: Yb body
ontology: CC
definition:
A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell.


go_id: GO:0070726
term: cell wall assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells.


go_id: GO:0070727
term: cellular macromolecule localization
ontology: BP
definition:
Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.


go_id: GO:0070729
term: cyclic nucleotide transport
ontology: BP
definition:
The directed movement of a cyclic nucleotide, any nucleotide in which phosphate group is in diester linkage to two positions on the sugar residue, into, out of or within a cell.


go_id: GO:0070732
term: spindle envelope
ontology: CC
definition:
An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase.


go_id: GO:0070733
term: protein adenylyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to specific residues of target proteins.


go_id: GO:0070734
term: histone H3-K27 methylation
ontology: BP
definition:
The modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.


go_id: GO:0070735
term: protein-glycine ligase activity
ontology: MF
definition:
Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target protein.


go_id: GO:0070736
term: protein-glycine ligase activity, initiating
ontology: MF
definition:
Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein.


go_id: GO:0070737
term: protein-glycine ligase activity, elongating
ontology: MF
definition:
Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain.


go_id: GO:0070738
term: tubulin-glycine ligase activity
ontology: MF
definition:
Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin.


go_id: GO:0070739
term: protein-glutamic acid ligase activity
ontology: MF
definition:
Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein.


go_id: GO:0070740
term: tubulin-glutamic acid ligase activity
ontology: MF
definition:
Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.


go_id: GO:0070741
term: response to interleukin-6
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.


go_id: GO:0070742
term: C2H2 zinc finger domain binding
ontology: MF
definition:
Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.


go_id: GO:0070743
term: interleukin-23 complex
ontology: CC
definition:
A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space.


go_id: GO:0070744
term: interleukin-27 complex
ontology: CC
definition:
A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space.


go_id: GO:0070745
term: interleukin-35 complex
ontology: CC
definition:
A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space.


go_id: GO:0070747
term: interleukin-35 receptor activity
ontology: MF
definition:
Combining with interleukin-35 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0070750
term: regulation of interleukin-35 biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35.


go_id: GO:0070751
term: negative regulation of interleukin-35 biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35.


go_id: GO:0070752
term: positive regulation of interleukin-35 biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35.


go_id: GO:0070753
term: interleukin-35 production
ontology: BP
definition:
The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0070755
term: negative regulation of interleukin-35 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-35 production.


go_id: GO:0070756
term: positive regulation of interleukin-35 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-35 production.


go_id: GO:0070757
term: interleukin-35-mediated signaling pathway
ontology: BP
definition:
A series of molecular signals initiated by the binding of interleukin-35 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0070758
term: regulation of interleukin-35-mediated signaling pathway
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35-mediated binding to a cell surface receptor.


go_id: GO:0070759
term: negative regulation of interleukin-35-mediated signaling pathway
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor.


go_id: GO:0070760
term: positive regulation of interleukin-35-mediated signaling pathway
ontology: BP
definition:
Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor.


go_id: GO:0070761
term: pre-snoRNP complex
ontology: CC
definition:
A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes.


go_id: GO:0070762
term: nuclear pore transmembrane ring
ontology: CC
definition:
A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex.


go_id: GO:0070764
term: gamma-secretase-Delta1 complex
ontology: CC
definition:
A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex.


go_id: GO:0070765
term: gamma-secretase complex
ontology: CC
definition:
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein.


go_id: GO:0070766
term: endobrevin-synaptobrevin 2-alpha-SNAP-NSF-syntaxin-4 complex
ontology: CC
definition:
A SNARE complex that contains endobrevin (VAMP8), synaptobrevin 2 (VAMP2), alpha-SNAP, NSF, and syntaxin 4 (or orthologs thereof).


go_id: GO:0070767
term: BRCA1-Rad51 complex
ontology: CC
definition:
A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity.


go_id: GO:0070768
term: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Unc13 complex
ontology: CC
definition:
A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Unc13b (or orthologs thereof).


go_id: GO:0070769
term: alphaIIb-beta3 integrin-CIB complex
ontology: CC
definition:
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin.


go_id: GO:0070770
term: alphaIIb-beta3 integrin-CD47-FAK complex
ontology: CC
definition:
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK.


go_id: GO:0070771
term: alphaIIb-beta3 integrin-CD47-Src complex
ontology: CC
definition:
A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src.


go_id: GO:0070772
term: PAS complex
ontology: CC
definition:
A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.


go_id: GO:0070773
term: protein-N-terminal glutamine amidohydrolase activity
ontology: MF
definition:
Catalysis of the reaction: protein-N-terminal-L-glutamine + H2O = protein-N-terminal-L-glutamate + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein.


go_id: GO:0070776
term: MOZ/MORF histone acetyltransferase complex
ontology: CC
definition:
A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.


go_id: GO:0070777
term: D-aspartate transport
ontology: BP
definition:
The directed movement of D-aspartate, the D-enantiomer of the anion of (2R)-2-aminobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0070778
term: L-aspartate transport
ontology: BP
definition:
The directed movement of L-aspartate, the L-enantiomer of the anion of (2R)-2-aminobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0070779
term: D-aspartate import
ontology: BP
definition:
The directed movement of D-aspartate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle.


go_id: GO:0070781
term: response to biotin
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus.


go_id: GO:0070782
term: phosphatidylserine exposure on apoptotic cell surface
ontology: BP
definition:
A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity.


go_id: GO:0070783
term: growth of unicellular organism as a thread of attached cells
ontology: BP
definition:
A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions.


go_id: GO:0070784
term: regulation of growth of unicellular organism as a thread of attached cells
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium.


go_id: GO:0070785
term: negative regulation of growth of unicellular organism as a thread of attached cells
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium.


go_id: GO:0070786
term: positive regulation of growth of unicellular organism as a thread of attached cells
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium.


go_id: GO:0070787
term: conidiophore development
ontology: BP
definition:
The process whose specific outcome is the progression of the conidiophore over time, from its formation to the mature structure. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores.


go_id: GO:0070788
term: conidiophore stalk development
ontology: BP
definition:
The process whose specific outcome is the progression of the conidiophore stalk over time, from its formation to the mature structure. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop.


go_id: GO:0070789
term: metula development
ontology: BP
definition:
The process whose specific outcome is the progression of metulae over time, from its formation to the mature structure. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip.


go_id: GO:0070790
term: phialide development
ontology: BP
definition:
The process whose specific outcome is the progression of phialides over time, from its formation to the mature structure. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. Chains of conidia, or asexual spores, develop from the phialide tips.


go_id: GO:0070791
term: cleistothecium development
ontology: BP
definition:
The process whose specific outcome is the progression of the cleistothecium over time, from its formation to the mature structure. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella.


go_id: GO:0070792
term: Hulle cell development
ontology: BP
definition:
The process whose specific outcome is the progression of Hulle cells over time, from their formation to the mature structures. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body.


go_id: GO:0070793
term: regulation of conidiophore development
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores.


go_id: GO:0070794
term: negative regulation of conidiophore development
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores.


go_id: GO:0070795
term: positive regulation of conidiophore development
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores.


go_id: GO:0070796
term: regulation of cleistothecium development
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella.


go_id: GO:0070797
term: negative regulation of cleistothecium development
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella.


go_id: GO:0070798
term: positive regulation of cleistothecium development
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella.


go_id: GO:0070799
term: regulation of conidiophore stalk development
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop.


go_id: GO:0070800
term: negative regulation of conidiophore stalk development
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop.


go_id: GO:0070801
term: positive regulation of conidiophore stalk development
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop.


go_id: GO:0070802
term: regulation of metula development
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip.


go_id: GO:0070803
term: negative regulation of metula development
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip.


go_id: GO:0070804
term: positive regulation of metula development
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip.


go_id: GO:0070805
term: regulation of phialide development
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip.


go_id: GO:0070806
term: negative regulation of phialide development
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip.


go_id: GO:0070807
term: positive regulation of phialide development
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip.


go_id: GO:0070808
term: regulation of Hulle cell development
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body.


go_id: GO:0070809
term: negative regulation of Hulle cell development
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body.


go_id: GO:0070810
term: positive regulation of Hulle cell development
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body.


go_id: GO:0070811
term: glycerol-2-phosphate transport
ontology: BP
definition:
The directed movement of glycerol-2-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol-2-phosphate is a phosphoric monoester of glycerol.


go_id: GO:0070812
term: glycerol-2-phosphate-transporting ATPase activity
ontology: MF
definition:
Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-2-phosphate(out) = ADP + phosphate + glycerol-2-phosphate(in).


go_id: GO:0070815
term: peptidyl-lysine 5-dioxygenase activity
ontology: MF
definition:
Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2.


go_id: GO:0070816
term: phosphorylation of RNA polymerase II C-terminal domain
ontology: BP
definition:
The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex.


go_id: GO:0070817
term: P-TEFb-cap methyltransferase complex localization
ontology: BP
definition:
Any process in which the P-TEFb-cap methyltransferase complex is transported to, or maintained in, a specific location.


go_id: GO:0070819
term: menaquinone-dependent protoporphyrinogen oxidase activity
ontology: MF
definition:
Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone.


go_id: GO:0070820
term: tertiary granule
ontology: CC
definition:
A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells.


go_id: GO:0070822
term: Sin3-type complex
ontology: CC
definition:
Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex.


go_id: GO:0070823
term: HDA1 complex
ontology: CC
definition:
A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p.


go_id: GO:0070824
term: SHREC complex
ontology: CC
definition:
A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures.


go_id: GO:0070825
term: micropyle
ontology: CC
definition:
An external encapsulating structure part of the chorion. A single cone-shaped specialization that forms an opening in the chorion that allows sperm entry into the egg prior to fertilization.


go_id: GO:0070826
term: paraferritin complex
ontology: CC
definition:
A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme.


go_id: GO:0070827
term: chromatin maintenance
ontology: BP
definition:
The chromatin organization process that preserves chromatin in a stable functional or structural state.


go_id: GO:0070828
term: heterochromatin organization
ontology: BP
definition:
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin.


go_id: GO:0070829
term: heterochromatin maintenance
ontology: BP
definition:
The chromatin organization process that preserves heterochromatin in a stable functional or structural state.


go_id: GO:0070830
term: bicellular tight junction assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet.


go_id: GO:0070831
term: basement membrane assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue.


go_id: GO:0070832
ontology: BP
term:
phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline

definition:
The phosphatidylcholine biosynthetic process that begins with three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine.


go_id: GO:0070833
term: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine
ontology: BP
definition:
The phosphatidylcholine biosynthetic process that begins with an initial N-methylation with phospho-base phosphoethanolamine, followed by two downstream N-methylations on phosphatidyl-bases, phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine. The process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine.


go_id: GO:0070834
ontology: BP
term:
phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine

definition:
The phosphatidylcholine biosynthetic process that begins with two N-methylations with phospho-base phosphoethanolamine and phospho-N-methylethanolamine, followed by a downstream N-methylation on phosphatidyl-base phosphatidyl-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine.


go_id: GO:0070836
term: caveola assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane.


go_id: GO:0070837
term: dehydroascorbic acid transport
ontology: BP
definition:
The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C.


go_id: GO:0070838
term: divalent metal ion transport
ontology: BP
definition:
The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0070839
term: divalent metal ion export
ontology: BP
definition:
The directed movement of divalent metal cations, any metal ion with a +2 electric charge, out of a cell or organelle.


go_id: GO:0070840
term: dynein complex binding
ontology: MF
definition:
Interacting selectively and non-covalently with a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.


go_id: GO:0070842
term: aggresome assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein.


go_id: GO:0070843
term: misfolded protein transport
ontology: BP
definition:
The directed movement of misfolded proteins in a cell, including the movement of proteins between specific compartments or structures within a cell.


go_id: GO:0070844
term: polyubiquitinated protein transport
ontology: BP
definition:
The directed movement of polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell.


go_id: GO:0070845
term: polyubiquitinated misfolded protein transport
ontology: BP
definition:
The directed movement of misfolded polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell.


go_id: GO:0070847
term: core mediator complex
ontology: CC
definition:
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.


go_id: GO:0070849
term: response to epidermal growth factor
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.


go_id: GO:0070850
term: TACC/TOG complex
ontology: CC
definition:
A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase.


go_id: GO:0070852
term: cell body fiber
ontology: CC
definition:
A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches.


go_id: GO:0070853
term: myosin VI binding
ontology: MF
definition:
Interacting selectively and non-covalently with a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments.


go_id: GO:0070857
term: regulation of bile acid biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.


go_id: GO:0070858
term: negative regulation of bile acid biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.


go_id: GO:0070859
term: positive regulation of bile acid biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.


go_id: GO:0070860
term: RNA polymerase I core factor complex
ontology: CC
definition:
A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p.


go_id: GO:0070861
term: regulation of protein exit from endoplasmic reticulum
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum.


go_id: GO:0070862
term: negative regulation of protein exit from endoplasmic reticulum
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum.


go_id: GO:0070863
term: positive regulation of protein exit from endoplasmic reticulum
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum.


go_id: GO:0070864
term: sperm individualization complex
ontology: CC
definition:
A macromolecular complex that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst.


go_id: GO:0070865
term: investment cone
ontology: CC
definition:
A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization.


go_id: GO:0070866
term: sterol-dependent protein binding
ontology: MF
definition:
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) in the presence of sterols.


go_id: GO:0070868
term: heterochromatin organization involved in chromatin silencing
ontology: BP
definition:
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing.


go_id: GO:0070869
term: heterochromatin assembly involved in chromatin silencing
ontology: BP
definition:
Any process that results in the assembly of chromatin into heterochromatin and contributes to chromatin silencing.


go_id: GO:0070870
term: heterochromatin maintenance involved in chromatin silencing
ontology: BP
definition:
A chromatin organization process that preserves heterochromatin in a stable functional or structural state, and that contributes to chromatin silencing.


go_id: GO:0070873
term: regulation of glycogen metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen.


go_id: GO:0070874
term: negative regulation of glycogen metabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen.


go_id: GO:0070875
term: positive regulation of glycogen metabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen.


go_id: GO:0070876
term: SOSS complex
ontology: CC
definition:
A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80.


go_id: GO:0070877
term: microprocessor complex
ontology: CC
definition:
A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs.


go_id: GO:0070878
term: primary miRNA binding
ontology: MF
definition:
Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding.


go_id: GO:0070879
term: fungal-type cell wall beta-glucan metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells.


go_id: GO:0070880
term: fungal-type cell wall beta-glucan biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells.


go_id: GO:0070883
term: pre-miRNA binding
ontology: MF
definition:
Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA.


go_id: GO:0070885
term: negative regulation of calcineurin-NFAT signaling cascade
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.


go_id: GO:0070886
term: positive regulation of calcineurin-NFAT signaling cascade
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade.


go_id: GO:0070888
term: E-box binding
ontology: MF
definition:
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.


go_id: GO:0070889
term: platelet alpha granule organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets.


go_id: GO:0070890
term: sodium-dependent L-ascorbate transmembrane transporter activity
ontology: MF
definition:
Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in).


go_id: GO:0070893
term: transposon integration
ontology: BP
definition:
Any process in which a transposable element is incorporated into another DNA molecule such as a chromosome.


go_id: GO:0070894
term: regulation of transposon integration
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of regulation of transposon integration, a process in which a transposable element is incorporated into another DNA molecule.


go_id: GO:0070895
term: negative regulation of transposon integration
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule.


go_id: GO:0070896
term: positive regulation of transposon integration
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule.


go_id: GO:0070897
term: DNA-templated transcriptional preinitiation complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.


go_id: GO:0070898
term: RNA polymerase III transcriptional preinitiation complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter.


go_id: GO:0070899
term: mitochondrial tRNA wobble uridine modification
ontology: BP
definition:
The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified.


go_id: GO:0070900
term: mitochondrial tRNA modification
ontology: BP
definition:
The covalent alteration of one or more nucleotides within a mitochondrial tRNA molecule to produce a mitochondrial tRNA molecule with a sequence that differs from that coded genetically.


go_id: GO:0070901
term: mitochondrial tRNA methylation
ontology: BP
definition:
The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule.


go_id: GO:0070910
term: cell wall macromolecule catabolic process involved in cell wall disassembly
ontology: BP
definition:
The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the cell wall.


go_id: GO:0070911
term: global genome nucleotide-excision repair
ontology: BP
definition:
The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome.


go_id: GO:0070912
term: Ddb1-Ckn1 complex
ontology: CC
definition:
A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases.


go_id: GO:0070913
term: Ddb1-Wdr21 complex
ontology: CC
definition:
A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases.


go_id: GO:0070914
term: UV-damage excision repair
ontology: BP
definition:
A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs).


go_id: GO:0070916
term: inositol phosphoceramide synthase complex
ontology: CC
definition:
A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces).


go_id: GO:0070918
term: production of small RNA involved in gene silencing by RNA
ontology: BP
definition:
The process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease.


go_id: GO:0070919
term: production of siRNA involved in chromatin silencing by small RNA
ontology: BP
definition:
Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of chromatin silencing by small RNA.


go_id: GO:0070920
term: regulation of production of small RNA involved in gene silencing by RNA
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the production of small RNA involved in gene silencing by RNA.


go_id: GO:0070921
term: regulation of production of siRNA involved in chromatin silencing by small RNA
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of chromatin silencing by small RNA.


go_id: GO:0070922
term: small RNA loading onto RISC
ontology: BP
definition:
The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA.


go_id: GO:0070923
term: siRNA loading onto RISC involved in chromatin silencing by small RNA
ontology: BP
definition:
The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of chromatin silencing by small RNA.


