# uniprot

uniprot_information_type:
SwissProt: Q9Y4H4 # The GoLoco 1 and/or GoLoco 3 domains exhibit GDI activity towards GDP-bound G(i) alpha protein, but not the GoLoco 2 domain# Contains 3 GoLoco domains

uniprot_information:
SwissProt: Q9Y4H4 # The GoLoco 1 and/or GoLoco 3 domains exhibit GDI activity towards GDP-bound G(i) alpha protein, but not the GoLoco 2 domain# Contains 3 GoLoco domains


uniprot_information_type:
SwissProt: Q03519 # The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2# Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily &  Contains 1 ABC transmembrane type-1 domain &  Contains 1 ABC transporter domain

uniprot_information:
SwissProt: Q03519 # The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2# Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily &  Contains 1 ABC transmembrane type-1 domain &  Contains 1 ABC transporter domain


uniprot_information_type:
SwissProt: Q03518 # The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2# Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily &  Contains 1 ABC transmembrane type-1 domain &  Contains 1 ABC transporter domain

uniprot_information:
SwissProt: Q03518 # The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2# Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily &  Contains 1 ABC transmembrane type-1 domain &  Contains 1 ABC transporter domain


uniprot_information_type:
SwissProt: P28702 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR2 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P28702 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR2 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: Q16611 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family# Belongs to the Bcl-2 family

uniprot_information:
SwissProt: Q16611 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family# Belongs to the Bcl-2 family


uniprot_information_type:
SwissProt: Q15544 # TBP and TAFII18 bind to distinct domains of TAFII28# Belongs to the TAF11 family

uniprot_information:
SwissProt: Q15544 # TBP and TAFII18 bind to distinct domains of TAFII28# Belongs to the TAF11 family


uniprot_information_type: SwissProt: Q96SB4
uniprot_information:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q15208
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9NZB8
uniprot_information:
In the C-terminal section; belongs to the moaC family &  In the N-terminal section; belongs to the moaA/nifB/pqqE family


uniprot_information_type:
SwissProt: P19484 # The leucin zipper region is essential for homo- or heterodimerization and high-affinity DNA binding. DNA binding is mediated by the basic region# Belongs to the MiT/TFE family &  Contains 1 basic helix-loop-helix (bHLH) domain

uniprot_information:
SwissProt: P19484 # The leucin zipper region is essential for homo- or heterodimerization and high-affinity DNA binding. DNA binding is mediated by the basic region# Belongs to the MiT/TFE family &  Contains 1 basic helix-loop-helix (bHLH) domain


uniprot_information_type:
SwissProt: Q9NZA1 # Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity)# Belongs to the chloride channel CLIC family &  Contains 1 GST C-terminal domain

uniprot_information:
SwissProt: Q9NZA1 # Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity)# Belongs to the chloride channel CLIC family &  Contains 1 GST C-terminal domain


uniprot_information_type: SwissProt: Q8IZF2
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 1 GPS domain &  Contains 3 Ig-like (immunoglobulin-like) domains &  Contains 1 SEA domain


uniprot_information_type: SwissProt: Q5T601
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 1 GPS domain &  Contains 1 SEA domain


uniprot_information_type:
SwissProt: P08263 # The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity# Belongs to the GST superfamily. Alpha family &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain

uniprot_information:
SwissProt: P08263 # The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity# Belongs to the GST superfamily. Alpha family &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain


uniprot_information_type: SwissProt: Q16772
uniprot_information:
Belongs to the GST superfamily. Alpha family &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain


uniprot_information_type: SwissProt: Q96P44
uniprot_information:
Belongs to the fibril-associated collagens with interrupted helices (FACIT) family &  Contains 6 collagen-like domains &  Contains 1 TSP N-terminal (TSPN) domain &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q03001 # The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends# Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 2 EF-hand domains &  Contains 1 GAR domain &  Contains 23 LRR (leucine-rich) repeats &  Contains 5 plectin repeats &  Contains 1 SH3 domain &  Contains 20 spectrin repeats

uniprot_information:
SwissProt: Q03001 # The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends# Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 2 EF-hand domains &  Contains 1 GAR domain &  Contains 23 LRR (leucine-rich) repeats &  Contains 5 plectin repeats &  Contains 1 SH3 domain &  Contains 20 spectrin repeats


uniprot_information_type:
SwissProt: P20849 # Each subunit is composed of three triple-helical domains interspersed with non-collagenous domains. The globular domain at the N-terminus of type IX collagen molecules represents the NC4 domain which may participate in electrostatic interactions with polyanionic glycosaminoglycans in cartilage# Belongs to the fibril-associated collagens with interrupted helices (FACIT) family &  Contains 1 TSP N-terminal (TSPN) domain

uniprot_information:
SwissProt: P20849 # Each subunit is composed of three triple-helical domains interspersed with non-collagenous domains. The globular domain at the N-terminus of type IX collagen molecules represents the NC4 domain which may participate in electrostatic interactions with polyanionic glycosaminoglycans in cartilage# Belongs to the fibril-associated collagens with interrupted helices (FACIT) family &  Contains 1 TSP N-terminal (TSPN) domain


uniprot_information_type:
SwissProt: Q9GZR5 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the ELO family

uniprot_information:
SwissProt: Q9GZR5 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the ELO family


uniprot_information_type:
SwissProt: O60641 # Possesses a three domain structure: the N-terminal 300 residues harbor a clathrin binding site, an acidic middle domain 450 residues, interrupted by an Ala-rich segment, and the C-terminal domain (166 residues)# Contains 1 ENTH (epsin N-terminal homology) domain

uniprot_information:
SwissProt: O60641 # Possesses a three domain structure: the N-terminal 300 residues harbor a clathrin binding site, an acidic middle domain 450 residues, interrupted by an Ala-rich segment, and the C-terminal domain (166 residues)# Contains 1 ENTH (epsin N-terminal homology) domain


uniprot_information_type:
SwissProt: O60506 # The domain containing eight Arg-Gly-Gly repeats may be involved in RNA-binding and protein-protein interactions# Contains 3 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: O60506 # The domain containing eight Arg-Gly-Gly repeats may be involved in RNA-binding and protein-protein interactions# Contains 3 RRM (RNA recognition motif) domains


uniprot_information_type: SwissProt: O60942
uniprot_information:
In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family &  In the C-terminal section; belongs to the eukaryotic GTase family


uniprot_information_type: SwissProt: P24046
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub-subfamily


uniprot_information_type: SwissProt: P28476
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily


uniprot_information_type: SwissProt: P81133
uniprot_information:
Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 2 PAS (PER-ARNT-SIM) domains &  Contains 1 Single-minded C-terminal domain


uniprot_information_type: SwissProt: Q8N3C0
uniprot_information:
Belongs to the helicase family &  Contains 2 helicase ATP-binding domains &  Contains 2 helicase C-terminal domains &  Contains 3 SEC63 domains


uniprot_information_type:
SwissProt: O60493 # The PX domain mediates specific binding to phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3)# Belongs to the sorting nexin family &  Contains 1 PX (phox homology) domain

uniprot_information:
SwissProt: O60493 # The PX domain mediates specific binding to phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3)# Belongs to the sorting nexin family &  Contains 1 PX (phox homology) domain


uniprot_information_type:
SwissProt: Q8TDZ2 # The C-terminal coiled coil part contains the plexin-interacting region# Contains 1 CH (calponin-homology) domain &  Contains 1 LIM zinc-binding domain

uniprot_information:
SwissProt: Q8TDZ2 # The C-terminal coiled coil part contains the plexin-interacting region# Contains 1 CH (calponin-homology) domain &  Contains 1 LIM zinc-binding domain


uniprot_information_type: SwissProt: O43167
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 A.T hook DNA-binding domain &  Contains 1 BTB (POZ) domain &  Contains 8 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q92558 # Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain# Belongs to the SCAR/WAVE family &  Contains 1 WH2 domain

uniprot_information:
SwissProt: Q92558 # Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain# Belongs to the SCAR/WAVE family &  Contains 1 WH2 domain


uniprot_information_type:
SwissProt: O60673 # Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis# Belongs to the DNA polymerase type-B family

uniprot_information:
SwissProt: O60673 # Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis# Belongs to the DNA polymerase type-B family


uniprot_information_type:
SwissProt: Q16363 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domain G is globular# Contains 4 laminin EGF-like domains &  Contains 5 laminin G-like domains

uniprot_information:
SwissProt: Q16363 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domain G is globular# Contains 4 laminin EGF-like domains &  Contains 5 laminin G-like domains


uniprot_information_type: SwissProt: P08922
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily &  Contains 9 fibronectin type-III domains &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O00141 # Isoform 2 subcellular localization at the plasma membrane is mediated by the sequences within the first 120 amino acids# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: O00141 # Isoform 2 subcellular localization at the plasma membrane is mediated by the sequences within the first 120 amino acids# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: P15260
uniprot_information:
Belongs to the type II cytokine receptor family &  Contains 2 fibronectin type-III domains &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: O95278
uniprot_information:
Belongs to the protein-tyrosine phosphatase family &  Contains 1 CBM20 (carbohydrate binding type-20) domain &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: O75449 # The N-terminus is sufficient for interaction with microtubules, although high affinity binding requires an intact C-terminal domain and ATP, which promotes oligomerization (By similarity)# Belongs to the AAA ATPase family

uniprot_information:
SwissProt: O75449 # The N-terminus is sufficient for interaction with microtubules, although high affinity binding requires an intact C-terminal domain and ATP, which promotes oligomerization (By similarity)# Belongs to the AAA ATPase family


uniprot_information_type: SwissProt: O95835
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain &  Contains 1 UBA domain


uniprot_information_type:
SwissProt: Q8NF91 # The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains# Belongs to the nesprin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 12 HAT repeats &  Contains 1 KASH domain &  Contains 31 spectrin repeats

uniprot_information:
SwissProt: Q8NF91 # The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains# Belongs to the nesprin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 12 HAT repeats &  Contains 1 KASH domain &  Contains 31 spectrin repeats


uniprot_information_type:
SwissProt: Q9UKT4 # The C-terminal region is required for inhibition of APC activity# Contains 1 F-box domain &  Contains 1 IBR-type zinc finger

uniprot_information:
SwissProt: Q9UKT4 # The C-terminal region is required for inhibition of APC activity# Contains 1 F-box domain &  Contains 1 IBR-type zinc finger


uniprot_information_type: SwissProt: P08519
uniprot_information:
Belongs to the peptidase S1 family. Plasminogen subfamily &  Contains 38 kringle domains &  Contains 1 peptidase S1 domain


uniprot_information_type:
SwissProt: Q9NRZ5 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

uniprot_information:
SwissProt: Q9NRZ5 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


uniprot_information_type:
SwissProt: O60260 # The ubiquitin-like domain binds the PSMD4 subunit of 26S proteasomes# Belongs to the RBR family. Parkin subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers &  Contains 1 ubiquitin-like domain

uniprot_information:
SwissProt: O60260 # The ubiquitin-like domain binds the PSMD4 subunit of 26S proteasomes# Belongs to the RBR family. Parkin subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers &  Contains 1 ubiquitin-like domain


uniprot_information_type:
SwissProt: Q9Y233 # The tandem GAF domains bind cAMP, and regulate enzyme activity. The binding of cAMP stimulates enzyme activity &  Composed of a C-terminal catalytic domain containing two divalent metal sites and an N-terminal regulatory domain which contains one cyclic nucleotide-binding region# Belongs to the cyclic nucleotide phosphodiesterase family &  Contains 2 GAF domains

uniprot_information:
SwissProt: Q9Y233 # The tandem GAF domains bind cAMP, and regulate enzyme activity. The binding of cAMP stimulates enzyme activity &  Composed of a C-terminal catalytic domain containing two divalent metal sites and an N-terminal regulatory domain which contains one cyclic nucleotide-binding region# Belongs to the cyclic nucleotide phosphodiesterase family &  Contains 2 GAF domains


uniprot_information_type: SwissProt: P35442
uniprot_information:
Belongs to the thrombospondin family &  Contains 3 EGF-like domains &  Contains 1 TSP C-terminal (TSPC) domain &  Contains 1 TSP N-terminal (TSPN) domain &  Contains 3 TSP type-1 domains &  Contains 8 TSP type-3 repeats &  Contains 1 VWFC domain


uniprot_information_type:
SwissProt: P18615 # The RRM domain interacts with RNA, and is essential for NELF complex function. It is however not required for the NELF complex formation# Belongs to the RRM NELF-E family &  Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: P18615 # The RRM domain interacts with RNA, and is essential for NELF complex function. It is however not required for the NELF complex formation# Belongs to the RRM NELF-E family &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type: SwissProt: Q13546
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 1 death domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P15924 # The N-terminal region is required for localization to the desmosomal plaque and interacts with the N-terminal region of plakophilin 1. The C-terminal region interacts with intermediate filaments# Belongs to the plakin or cytolinker family &  Contains 17 plectin repeats &  Contains 2 spectrin repeats

uniprot_information:
SwissProt: P15924 # The N-terminal region is required for localization to the desmosomal plaque and interacts with the N-terminal region of plakophilin 1. The C-terminal region interacts with intermediate filaments# Belongs to the plakin or cytolinker family &  Contains 17 plectin repeats &  Contains 2 spectrin repeats


uniprot_information_type:
SwissProt: P15822 # Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a fifth zinc-finger in-between# Contains 5 C2H2-type zinc fingers

uniprot_information:
SwissProt: P15822 # Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a fifth zinc-finger in-between# Contains 5 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q92833 # The ARID domain is required to target the PRC2 complex to its target genes (By similarity) &  The GSGFP motif is required for the interaction with SUZ12 (By similarity)# Contains 1 ARID domain &  Contains 1 JmjC domain &  Contains 1 JmjN domain

uniprot_information:
SwissProt: Q92833 # The ARID domain is required to target the PRC2 complex to its target genes (By similarity) &  The GSGFP motif is required for the interaction with SUZ12 (By similarity)# Contains 1 ARID domain &  Contains 1 JmjC domain &  Contains 1 JmjN domain


uniprot_information_type:
SwissProt: Q8WY64 # The RING domain mediates ubiquitination and the neurite outgrowth inhibitory activity# Contains 1 FERM domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8WY64 # The RING domain mediates ubiquitination and the neurite outgrowth inhibitory activity# Contains 1 FERM domain &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q5VV42
uniprot_information:
Belongs to the methylthiotransferase family. CDKAL1 subfamily &  Contains 1 MTTase N-terminal domain &  Contains 1 TRAM domain


uniprot_information_type: SwissProt: O00635
uniprot_information:
Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: P78410
uniprot_information:
Belongs to the immunoglobulin superfamily. BTN/MOG family &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: Q8WVV5
uniprot_information:
Belongs to the immunoglobulin superfamily. BTN/MOG family &  Contains 1 B30.2/SPRY domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: O00481
uniprot_information:
Belongs to the immunoglobulin superfamily. BTN/MOG family &  Contains 1 B30.2/SPRY domain &  Contains 2 Ig-like V-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q9H4T2
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 4 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: Q15776
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 9 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: O15535
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type:
SwissProt: P07437 # The highly acidic C-terminal region may bind cations such as calcium# Belongs to the tubulin family

uniprot_information:
SwissProt: P07437 # The highly acidic C-terminal region may bind cations such as calcium# Belongs to the tubulin family


uniprot_information_type:
SwissProt: Q08345 # The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates# Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily &  Contains 1 F5/8 type C domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q08345 # The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates# Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily &  Contains 1 F5/8 type C domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q29983
uniprot_information:
Belongs to the MHC class I family. MIC subfamily &  Contains 1 Ig-like C1-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P06681
uniprot_information:
Belongs to the peptidase S1 family &  Contains 1 peptidase S1 domain &  Contains 3 Sushi (CCP/SCR) domains &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q14573 # The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region# Belongs to the InsP3 receptor family &  Contains 5 MIR domains

uniprot_information:
SwissProt: Q14573 # The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region# Belongs to the InsP3 receptor family &  Contains 5 MIR domains


uniprot_information_type:
SwissProt: Q9H4E7 # The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding# Contains 1 PH domain

uniprot_information:
SwissProt: Q9H4E7 # The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding# Contains 1 PH domain


uniprot_information_type:
SwissProt: Q16539 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q16539 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O15264 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: O15264 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P38936 # The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination# Belongs to the CDI family

uniprot_information:
SwissProt: P38936 # The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination# Belongs to the CDI family


uniprot_information_type:
SwissProt: Q7Z6J4 # The FYVE-type zinc-finger is necessary for early endosome localization. Recruitement to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides (By similarity) &  The PH domain is necessary for localization to the ruffle membrane. Recruitement to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein (By similarity) &  The DH domain is necessary for its ability to activate JNK1 via CDC42 (By similarity)# Contains 1 DH (DBL-homology) domain &  Contains 1 FYVE-type zinc finger &  Contains 2 PH domains

uniprot_information:
SwissProt: Q7Z6J4 # The FYVE-type zinc-finger is necessary for early endosome localization. Recruitement to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides (By similarity) &  The PH domain is necessary for localization to the ruffle membrane. Recruitement to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein (By similarity) &  The DH domain is necessary for its ability to activate JNK1 via CDC42 (By similarity)# Contains 1 DH (DBL-homology) domain &  Contains 1 FYVE-type zinc finger &  Contains 2 PH domains


uniprot_information_type: SwissProt: P11309
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O76064 # The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and Thr-4827 phosphorylated HERC2# Belongs to the RNF8 family &  Contains 1 FHA domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: O76064 # The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and Thr-4827 phosphorylated HERC2# Belongs to the RNF8 family &  Contains 1 FHA domain &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q8N1G2
uniprot_information:
Belongs to the methyltransferase superfamily. RrmJ family &  Contains 1 G-patch domain &  Contains 1 WW domain


uniprot_information_type: SwissProt: Q86T65
uniprot_information:
Belongs to the formin homology family &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


uniprot_information_type:
SwissProt: Q5TGU0 # The C-terminal region mediates cholesterol-binding (By similarity)# Belongs to the TspO/BZRP family

uniprot_information:
SwissProt: Q5TGU0 # The C-terminal region mediates cholesterol-binding (By similarity)# Belongs to the TspO/BZRP family


uniprot_information_type:
SwissProt: Q8IWV8 # The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif# Belongs to the UBR1 family &  Contains 1 RING-type zinc finger &  Contains 1 UBR-type zinc finger

uniprot_information:
SwissProt: Q8IWV8 # The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif# Belongs to the UBR1 family &  Contains 1 RING-type zinc finger &  Contains 1 UBR-type zinc finger


uniprot_information_type: SwissProt: Q13308
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily &  Contains 7 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8IWT3 # The IBR domain is required for interaction with UBCH7 and UBCH8# Belongs to the cullin family &  Contains 1 DOC domain &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers

uniprot_information:
SwissProt: Q8IWT3 # The IBR domain is required for interaction with UBCH7 and UBCH8# Belongs to the cullin family &  Contains 1 DOC domain &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers


uniprot_information_type:
SwissProt: Q9Y253 # The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity# Belongs to the DNA polymerase type-Y family &  Contains 1 umuC domain

uniprot_information:
SwissProt: Q9Y253 # The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity# Belongs to the DNA polymerase type-Y family &  Contains 1 umuC domain


uniprot_information_type: SwissProt: Q9UMQ6
uniprot_information:
Belongs to the peptidase C2 family &  Contains 1 calpain catalytic domain &  Contains 2 EF-hand domains


uniprot_information_type: SwissProt: Q16819
uniprot_information:
Belongs to the peptidase M12A family &  Contains 1 EGF-like domain &  Contains 1 MAM domain &  Contains 1 MATH domain


uniprot_information_type:
SwissProt: Q9Y5K6 # The Pro-rich domain may mediate binding to SH3 domains &  Potential homodimerization is mediated by the coiled coil domain# Contains 3 SH3 domains

uniprot_information:
SwissProt: Q9Y5K6 # The Pro-rich domain may mediate binding to SH3 domains &  Potential homodimerization is mediated by the coiled coil domain# Contains 3 SH3 domains


uniprot_information_type: SwissProt: O60242
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 1 CUB domain &  Contains 1 GPS domain &  Contains 4 TSP type-1 domains


uniprot_information_type:
SwissProt: Q14993 # The numerous interruptions in the triple helix may make this molecule either elastic or flexible# Belongs to the fibril-associated collagens with interrupted helices (FACIT) family &  Contains 1 TSP N-terminal (TSPN) domain

uniprot_information:
SwissProt: Q14993 # The numerous interruptions in the triple helix may make this molecule either elastic or flexible# Belongs to the fibril-associated collagens with interrupted helices (FACIT) family &  Contains 1 TSP N-terminal (TSPN) domain


uniprot_information_type: SwissProt: Q86UR5
uniprot_information:
Contains 2 C2 domains &  Contains 1 FYVE-type zinc finger &  Contains 1 PDZ (DHR) domain &  Contains 1 RabBD (Rab-binding) domain


uniprot_information_type: SwissProt: Q9NXZ2
uniprot_information:
Belongs to the DEAD box helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 KH domain


uniprot_information_type:
SwissProt: Q9UM54 # Divided into three regions: a N-terminal motor (head) domain, followed by a neck domain consisting of a calmodulin-binding linker domain and a single IQ motif, and a C-terminal tail region with a coiled-coil and a unique globular domain required for interaction with other proteins# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: Q9UM54 # Divided into three regions: a N-terminal motor (head) domain, followed by a neck domain consisting of a calmodulin-binding linker domain and a single IQ motif, and a C-terminal tail region with a coiled-coil and a unique globular domain required for interaction with other proteins# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type: SwissProt: Q7L1T6
uniprot_information:
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family &  Contains 1 CS domain &  Contains 1 cytochrome b5 heme-binding domain &  Contains 1 FAD-binding FR-type domain


uniprot_information_type:
SwissProt: Q12796 # The interaction between PNRC1 and nuclear receptors is dependent on the SH3 binding motif# Belongs to the PNRC family. PNRC1 subfamily

uniprot_information:
SwissProt: Q12796 # The interaction between PNRC1 and nuclear receptors is dependent on the SH3 binding motif# Belongs to the PNRC family. PNRC1 subfamily


uniprot_information_type: SwissProt: Q9Y4K1
uniprot_information:
Belongs to the beta/gamma-crystallin family &  Contains 12 beta/gamma crystallin 'Greek key' domains &  Contains 1 ricin B-type lectin domain


uniprot_information_type: SwissProt: O95389
uniprot_information:
Belongs to the CCN family &  Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 1 IGFBP N-terminal domain &  Contains 1 TSP type-1 domain


uniprot_information_type:
SwissProt: O15131 # Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import &  The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity) &  The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)# Belongs to the importin alpha family &  Contains 10 ARM repeats &  Contains 1 IBB domain

uniprot_information:
SwissProt: O15131 # Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import &  The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity) &  The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)# Belongs to the importin alpha family &  Contains 10 ARM repeats &  Contains 1 IBB domain


uniprot_information_type:
SwissProt: O15540 # Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

uniprot_information:
SwissProt: O15540 # Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


uniprot_information_type:
SwissProt: P24043 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domains VI, IV and G are globular# Contains 17 laminin EGF-like domains &  Contains 5 laminin G-like domains &  Contains 2 laminin IV type A domains &  Contains 1 laminin N-terminal domain

uniprot_information:
SwissProt: P24043 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domains VI, IV and G are globular# Contains 17 laminin EGF-like domains &  Contains 5 laminin G-like domains &  Contains 2 laminin IV type A domains &  Contains 1 laminin N-terminal domain


uniprot_information_type:
SwissProt: P22413 # The di-leucine motif is required for basolateral targeting in epithelial cells, and for targeting to matrix vesicles derived from mineralizing cells (By similarity)# Belongs to the nucleotide pyrophosphatase/phosphodiesterase family &  Contains 2 SMB (somatomedin-B) domains

uniprot_information:
SwissProt: P22413 # The di-leucine motif is required for basolateral targeting in epithelial cells, and for targeting to matrix vesicles derived from mineralizing cells (By similarity)# Belongs to the nucleotide pyrophosphatase/phosphodiesterase family &  Contains 2 SMB (somatomedin-B) domains


uniprot_information_type:
SwissProt: P10242 # Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression# Contains 3 HTH myb-type DNA-binding domains

uniprot_information:
SwissProt: P10242 # Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression# Contains 3 HTH myb-type DNA-binding domains


uniprot_information_type:
SwissProt: Q9NP56 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain# Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily

uniprot_information:
SwissProt: Q9NP56 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain# Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily


uniprot_information_type:
SwissProt: P21580 # The A20-type zinc fingers mediate the ubiquitin ligase activity &  The OTU domain mediates the deubiquitinase activity# Belongs to the peptidase C64 family &  Contains 7 A20-type zinc fingers &  Contains 1 OTU domain

uniprot_information:
SwissProt: P21580 # The A20-type zinc fingers mediate the ubiquitin ligase activity &  The OTU domain mediates the deubiquitinase activity# Belongs to the peptidase C64 family &  Contains 7 A20-type zinc fingers &  Contains 1 OTU domain


uniprot_information_type: SwissProt: Q86SQ4
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 1 CUB domain &  Contains 1 GPS domain &  Contains 1 pentaxin domain


uniprot_information_type: SwissProt: P46939
uniprot_information:
Contains 2 CH (calponin-homology) domains &  Contains 20 spectrin repeats &  Contains 1 WW domain &  Contains 1 ZZ-type zinc finger


uniprot_information_type: SwissProt: P22061
uniprot_information:
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family


uniprot_information_type:
SwissProt: Q02952 # Polybasic regions located between residues 266 and 557 are involved in binding PKC# Contains 3 AKAP domains

uniprot_information:
SwissProt: Q02952 # Polybasic regions located between residues 266 and 557 are involved in binding PKC# Contains 3 AKAP domains


uniprot_information_type:
SwissProt: P03372 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P03372 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: Q8IVF5 # The PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure (By similarity)# Belongs to the TIAM family &  Contains 1 DH (DBL-homology) domain &  Contains 1 PDZ (DHR) domain &  Contains 2 PH domains &  Contains 1 RBD (Ras-binding) domain

uniprot_information:
SwissProt: Q8IVF5 # The PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure (By similarity)# Belongs to the TIAM family &  Contains 1 DH (DBL-homology) domain &  Contains 1 PDZ (DHR) domain &  Contains 2 PH domains &  Contains 1 RBD (Ras-binding) domain


uniprot_information_type:
SwissProt: Q8IZN3 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q8IZN3 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily &  Contains 1 DHHC-type zinc finger


uniprot_information_type: SwissProt: O15056
uniprot_information:
Belongs to the synaptojanin family &  In the central section; belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family &  Contains 1 RRM (RNA recognition motif) domain &  Contains 1 SAC domain


uniprot_information_type:
SwissProt: Q9NRJ4 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the TUB family &  Contains 1 SOCS box domain &  Contains 3 WD repeats

uniprot_information:
SwissProt: Q9NRJ4 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the TUB family &  Contains 1 SOCS box domain &  Contains 3 WD repeats


uniprot_information_type:
SwissProt: P11717 # Contains 15 repeating units of approximately 147 AA. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends# Belongs to the MRL1/IGF2R family &  Contains 1 fibronectin type-II domain

uniprot_information:
SwissProt: P11717 # Contains 15 repeating units of approximately 147 AA. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends# Belongs to the MRL1/IGF2R family &  Contains 1 fibronectin type-II domain


uniprot_information_type:
SwissProt: P00747 # Kringle domains mediate interaction with CSPG4# Belongs to the peptidase S1 family. Plasminogen subfamily &  Contains 5 kringle domains &  Contains 1 PAN domain &  Contains 1 peptidase S1 domain

uniprot_information:
SwissProt: P00747 # Kringle domains mediate interaction with CSPG4# Belongs to the peptidase S1 family. Plasminogen subfamily &  Contains 5 kringle domains &  Contains 1 PAN domain &  Contains 1 peptidase S1 domain


uniprot_information_type:
SwissProt: P55196 # The PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich N-terminus domain interacts with F-actin# Contains 1 dilute domain &  Contains 1 FHA domain &  Contains 1 PDZ (DHR) domain &  Contains 2 Ras-associating domains

uniprot_information:
SwissProt: P55196 # The PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich N-terminus domain interacts with F-actin# Contains 1 dilute domain &  Contains 1 FHA domain &  Contains 1 PDZ (DHR) domain &  Contains 2 Ras-associating domains


uniprot_information_type:
SwissProt: P04085 # The long form contains a basic insert which acts as a cell retention signal# Belongs to the PDGF/VEGF growth factor family

uniprot_information:
SwissProt: P04085 # The long form contains a basic insert which acts as a cell retention signal# Belongs to the PDGF/VEGF growth factor family


uniprot_information_type:
SwissProt: Q9NWF9 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers

uniprot_information:
SwissProt: Q9NWF9 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers


uniprot_information_type: SwissProt: Q9BQI3
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily &  Contains 2 HRM (heme regulatory motif) repeats &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9Y5W8
uniprot_information:
Belongs to the sorting nexin family &  Contains 1 PX (phox homology) domain &  Contains 1 PXA domain &  Contains 1 RGS domain


uniprot_information_type:
SwissProt: O00425 # The third and fourth KH domains are important for binding to the untranslated region (UTR) of target mRNA# Belongs to the RRM IMP/VICKZ family &  Contains 4 KH domains &  Contains 2 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: O00425 # The third and fourth KH domains are important for binding to the untranslated region (UTR) of target mRNA# Belongs to the RRM IMP/VICKZ family &  Contains 4 KH domains &  Contains 2 RRM (RNA recognition motif) domains


uniprot_information_type:
SwissProt: O75563 # The SH3 domain interacts with FYB and PTK2B# Belongs to the SKAP family &  Contains 1 PH domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: O75563 # The SH3 domain interacts with FYB and PTK2B# Belongs to the SKAP family &  Contains 1 PH domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: O43364
uniprot_information:
Belongs to the Antp homeobox family. Proboscipedia subfamily &  Contains 1 homeobox DNA-binding domain


uniprot_information_type:
SwissProt: Q6FHJ7 # The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the secreted frizzled-related protein (sFRP) family &  Contains 1 FZ (frizzled) domain &  Contains 1 NTR domain

uniprot_information:
SwissProt: Q6FHJ7 # The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the secreted frizzled-related protein (sFRP) family &  Contains 1 FZ (frizzled) domain &  Contains 1 NTR domain


uniprot_information_type: SwissProt: Q9NY93
uniprot_information:
Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: P17936 # The thyroglobulin type-1 domain mediates interaction with HN# Contains 1 IGFBP N-terminal domain &  Contains 1 thyroglobulin type-1 domain

uniprot_information:
SwissProt: P17936 # The thyroglobulin type-1 domain mediates interaction with HN# Contains 1 IGFBP N-terminal domain &  Contains 1 thyroglobulin type-1 domain


uniprot_information_type:
SwissProt: Q13322 # The PH domain binds relatively non-specifically to several phosphoinositides, including PI(5)P, PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3, with modest affinities# Belongs to the GRB7/10/14 family &  Contains 1 PH domain &  Contains 1 Ras-associating domain &  Contains 1 SH2 domain

uniprot_information:
SwissProt: Q13322 # The PH domain binds relatively non-specifically to several phosphoinositides, including PI(5)P, PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3, with modest affinities# Belongs to the GRB7/10/14 family &  Contains 1 PH domain &  Contains 1 Ras-associating domain &  Contains 1 SH2 domain


uniprot_information_type:
SwissProt: Q16816 # The two calmodulin-binding domains appear to act in concert to bind a single molecule of calmodulin and are pseudosubstrate/autoinhibitory domains (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q16816 # The two calmodulin-binding domains appear to act in concert to bind a single molecule of calmodulin and are pseudosubstrate/autoinhibitory domains (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9UIG0 # The N-terminal part (1-345), including the WAC domain and the C motif, mediates the tyrosine-protein kinase activity &  The bromo domain mediates the specific interaction with acetylated histones# Belongs to the WAL family. BAZ1B subfamily &  Contains 1 bromo domain &  Contains 1 DDT domain &  Contains 1 PHD-type zinc finger &  Contains 1 WAC domain

uniprot_information:
SwissProt: Q9UIG0 # The N-terminal part (1-345), including the WAC domain and the C motif, mediates the tyrosine-protein kinase activity &  The bromo domain mediates the specific interaction with acetylated histones# Belongs to the WAL family. BAZ1B subfamily &  Contains 1 bromo domain &  Contains 1 DDT domain &  Contains 1 PHD-type zinc finger &  Contains 1 WAC domain


uniprot_information_type:
SwissProt: O00291 # The pseudo DED region (pDED) mediates the interaction with IFT57 &  Binds F-actin via the talin-like I/LWEQ domain# Belongs to the SLA2 family &  Contains 1 ENTH (epsin N-terminal homology) domain &  Contains 1 I/LWEQ domain

uniprot_information:
SwissProt: O00291 # The pseudo DED region (pDED) mediates the interaction with IFT57 &  Binds F-actin via the talin-like I/LWEQ domain# Belongs to the SLA2 family &  Contains 1 ENTH (epsin N-terminal homology) domain &  Contains 1 I/LWEQ domain


uniprot_information_type: SwissProt: Q9Y6J8
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily &  Contains 1 rhodanese domain &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type: SwissProt: Q86UL8
uniprot_information:
Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 6 PDZ (DHR) domains &  Contains 2 WW domains


uniprot_information_type:
SwissProt: P54289 # The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch (By similarity)# Belongs to the calcium channel subunit alpha-2/delta family &  Contains 1 cache domain &  Contains 1 VWFA domain

uniprot_information:
SwissProt: P54289 # The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch (By similarity)# Belongs to the calcium channel subunit alpha-2/delta family &  Contains 1 cache domain &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q9Y6V0 # C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change# Contains 2 C2 domains &  Contains 1 PDZ (DHR) domain

uniprot_information:
SwissProt: Q9Y6V0 # C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change# Contains 2 C2 domains &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: Q14563 # Strong binding to neuropilin is mediated by the carboxy third of the protein# Belongs to the semaphorin family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 PSI domain &  Contains 1 Sema domain

uniprot_information:
SwissProt: Q14563 # Strong binding to neuropilin is mediated by the carboxy third of the protein# Belongs to the semaphorin family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 PSI domain &  Contains 1 Sema domain


uniprot_information_type:
SwissProt: O95025 # Strong binding to neuropilin is mediated by the carboxy third of the protein# Belongs to the semaphorin family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 PSI domain &  Contains 1 Sema domain

uniprot_information:
SwissProt: O95025 # Strong binding to neuropilin is mediated by the carboxy third of the protein# Belongs to the semaphorin family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 PSI domain &  Contains 1 Sema domain


uniprot_information_type: SwissProt: P21439
uniprot_information:
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily &  Contains 2 ABC transmembrane type-1 domains &  Contains 2 ABC transporter domains


uniprot_information_type:
SwissProt: Q99551 # Composed of three leucine zippers, one of which is bipartite, and two widely spaced basic domains. There is evidence that the leucine zippers form and intramolecular three-stranded coiled-coil that brings the basic domains together to form a DNA-binding motif# Belongs to the mTERF family

uniprot_information:
SwissProt: Q99551 # Composed of three leucine zippers, one of which is bipartite, and two widely spaced basic domains. There is evidence that the leucine zippers form and intramolecular three-stranded coiled-coil that brings the basic domains together to form a DNA-binding motif# Belongs to the mTERF family


uniprot_information_type:
SwissProt: P48307 # This inhibitor contains three inhibitory domains# Contains 3 BPTI/Kunitz inhibitor domains

uniprot_information:
SwissProt: P48307 # This inhibitor contains three inhibitory domains# Contains 3 BPTI/Kunitz inhibitor domains


uniprot_information_type: SwissProt: Q9HCE7
uniprot_information:
Contains 1 C2 domain &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 2 WW domains


uniprot_information_type:
SwissProt: Q9Y3D6 # The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L# Belongs to the FIS1 family &  Contains 1 TPR repeat

uniprot_information:
SwissProt: Q9Y3D6 # The C-terminus is required for mitochondrial or peroxisomal localization, while the N-terminus is necessary for mitochondrial or peroxisomal fission, localization and regulation of the interaction with DNM1L# Belongs to the FIS1 family &  Contains 1 TPR repeat


uniprot_information_type:
SwissProt: O43374 # The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-triphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members# Contains 1 Btk-type zinc finger &  Contains 2 C2 domains &  Contains 1 PH domain &  Contains 1 Ras-GAP domain

uniprot_information:
SwissProt: O43374 # The PH domain does not bind phosphatidylinositol 4,5-bisphosphate or phosphatidylinositol 3,4,5-triphosphate. This lack of binding activity is due to Leu-592, compared to Arg found in other family members# Contains 1 Btk-type zinc finger &  Contains 2 C2 domains &  Contains 1 PH domain &  Contains 1 Ras-GAP domain


uniprot_information_type:
SwissProt: P78509 # The basic C-terminal region is essential for secretion (By similarity)# Belongs to the reelin family &  Contains 16 BNR repeats &  Contains 8 EGF-like domains &  Contains 1 reelin domain

uniprot_information:
SwissProt: P78509 # The basic C-terminal region is essential for secretion (By similarity)# Belongs to the reelin family &  Contains 16 BNR repeats &  Contains 8 EGF-like domains &  Contains 1 reelin domain


uniprot_information_type:
SwissProt: P07942 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domains VI and IV are globular# Contains 13 laminin EGF-like domains &  Contains 1 laminin IV type B domain &  Contains 1 laminin N-terminal domain

uniprot_information:
SwissProt: P07942 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domains VI and IV are globular# Contains 13 laminin EGF-like domains &  Contains 1 laminin IV type B domain &  Contains 1 laminin N-terminal domain


uniprot_information_type:
SwissProt: A4D0S4 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domains VI and IV are globular# Contains 13 laminin EGF-like domains &  Contains 1 laminin IV type B domain &  Contains 1 laminin N-terminal domain

uniprot_information:
SwissProt: A4D0S4 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domains VI and IV are globular# Contains 13 laminin EGF-like domains &  Contains 1 laminin IV type B domain &  Contains 1 laminin N-terminal domain


uniprot_information_type:
SwissProt: Q8N1I0 # The DHR-2 domain probably mediates the GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q8N1I0 # The DHR-2 domain probably mediates the GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q16821 # The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes# Contains 1 CBM21 (carbohydrate binding type-21) domain

uniprot_information:
SwissProt: Q16821 # The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes# Contains 1 CBM21 (carbohydrate binding type-21) domain


uniprot_information_type: SwissProt: Q9UDR5
uniprot_information:
In the N-terminal section; belongs to the AlaDH/PNT family &  In the C-terminal section; belongs to the saccharopine dehydrogenase family


uniprot_information_type:
SwissProt: Q86UW7 # The PH domain is essential for regulated exocytosis and binds phospholipids (By similarity)# Contains 1 C2 domain &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q86UW7 # The PH domain is essential for regulated exocytosis and binds phospholipids (By similarity)# Contains 1 C2 domain &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: O00592 # Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis. The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with SLC9A3R1 and for targeting SLC9A3R1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation (By similarity). The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes# Belongs to the podocalyxin family

uniprot_information:
SwissProt: O00592 # Both the O-glycan-rich domain of the extracellular domain and the C-terminus PDZ-binding motif (DTHL) in the cytoplasmic tail harbor an apical sorting signal. The cytoplasmic domain is necessary for the apical membrane targeting and renal tubulogenesis. The cytoplasmic C-terminus PDZ-binding motif (DTHL) is essential for interaction with SLC9A3R1 and for targeting SLC9A3R1 to the apical cell membrane. The extracellular domain is necessary for microvillus formation (By similarity). The large highly anionic extracellular domain allows to maintain open filtration pathways between neighboring podocyte foot processes# Belongs to the podocalyxin family


uniprot_information_type: SwissProt: O95628
uniprot_information:
Contains 1 C3H1-type zinc finger &  Contains 1 RING-type zinc finger &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type: SwissProt: O75912
uniprot_information:
Belongs to the eukaryotic diacylglycerol kinase family &  Contains 2 ANK repeats &  Contains 1 DAGKc domain &  Contains 2 phorbol-ester/DAG-type zinc fingers


uniprot_information_type:
SwissProt: Q7Z2W4 # The second and fourth zinc fingers are involved in binding to specific viral RNAs (By similarity)# Contains 4 C3H1-type zinc fingers &  Contains 1 PARP catalytic domain &  Contains 1 WWE domain

uniprot_information:
SwissProt: Q7Z2W4 # The second and fourth zinc fingers are involved in binding to specific viral RNAs (By similarity)# Contains 4 C3H1-type zinc fingers &  Contains 1 PARP catalytic domain &  Contains 1 WWE domain


uniprot_information_type:
SwissProt: Q6ZMT4 # The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 prevents its access to H3K9me2 &  The linker region is a critical determinant of demethylase specificity. It prevents the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3, while it favors selectivity toward H3K27me2# Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily &  Contains 1 JmjC domain &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: Q6ZMT4 # The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 prevents its access to H3K9me2 &  The linker region is a critical determinant of demethylase specificity. It prevents the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3, while it favors selectivity toward H3K27me2# Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily &  Contains 1 JmjC domain &  Contains 1 PHD-type zinc finger


uniprot_information_type: SwissProt: Q9H1D0
uniprot_information:
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily &  Contains 5 ANK repeats


uniprot_information_type: SwissProt: Q9NQA5
uniprot_information:
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily &  Contains 5 ANK repeats


uniprot_information_type:
SwissProt: Q12809 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily &  Contains 1 cyclic nucleotide-binding domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain

uniprot_information:
SwissProt: Q12809 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily &  Contains 1 cyclic nucleotide-binding domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain


uniprot_information_type:
SwissProt: Q6ZW49 # The BRCT domains function as a single module and are necessary and sufficient for phospho-specific binding# Contains 5 BRCT domains

uniprot_information:
SwissProt: Q6ZW49 # The BRCT domains function as a single module and are necessary and sufficient for phospho-specific binding# Contains 5 BRCT domains


uniprot_information_type:
SwissProt: Q92932 # The cytoplasmic domain appears to contain the autoantigenic epitopes# Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily &  Contains 1 tyrosine-protein phosphatase domain

uniprot_information:
SwissProt: Q92932 # The cytoplasmic domain appears to contain the autoantigenic epitopes# Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: O94901 # The SUN domain may play a role in the nuclear anchoring and/or migration# Contains 1 SUN domain

uniprot_information:
SwissProt: O94901 # The SUN domain may play a role in the nuclear anchoring and/or migration# Contains 1 SUN domain


uniprot_information_type:
SwissProt: P55884 # The RRM domain mediates interaction with EIF3J# Belongs to the eIF-3 subunit B family &  Contains 1 RRM (RNA recognition motif) domain &  Contains 5 WD repeats

uniprot_information:
SwissProt: P55884 # The RRM domain mediates interaction with EIF3J# Belongs to the eIF-3 subunit B family &  Contains 1 RRM (RNA recognition motif) domain &  Contains 5 WD repeats


uniprot_information_type:
SwissProt: P63000 # The effector region mediates interaction with DEF6# Belongs to the small GTPase superfamily. Rho family

uniprot_information:
SwissProt: P63000 # The effector region mediates interaction with DEF6# Belongs to the small GTPase superfamily. Rho family


uniprot_information_type:
SwissProt: Q9NPG8 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q9NPG8 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: O15504 # The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC (By similarity)# Contains 1 C3H1-type zinc finger

uniprot_information:
SwissProt: O15504 # The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC (By similarity)# Contains 1 C3H1-type zinc finger


uniprot_information_type: SwissProt: Q9NZW5
uniprot_information:
Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 2 L27 domains &  Contains 1 PDZ (DHR) domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q8N427 # Contains 3 inactive NDK domains that each lack the active His residue, suggesting that they have no NDP kinase activity# In the C-terminal section; belongs to the NDK family &  Contains 1 thioredoxin domain

uniprot_information:
SwissProt: Q8N427 # Contains 3 inactive NDK domains that each lack the active His residue, suggesting that they have no NDP kinase activity# In the C-terminal section; belongs to the NDK family &  Contains 1 thioredoxin domain


uniprot_information_type: SwissProt: P78424
uniprot_information:
Belongs to the POU transcription factor family. Class-6 subfamily &  Contains 1 homeobox DNA-binding domain &  Contains 1 POU-specific domain


uniprot_information_type:
SwissProt: O15498 # The longin domain regulates palmitoylation and membrane targeting# Belongs to the synaptobrevin family &  Contains 1 longin domain &  Contains 1 v-SNARE coiled-coil homology domain

uniprot_information:
SwissProt: O15498 # The longin domain regulates palmitoylation and membrane targeting# Belongs to the synaptobrevin family &  Contains 1 longin domain &  Contains 1 v-SNARE coiled-coil homology domain


uniprot_information_type:
SwissProt: Q8NF64 # The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein# Contains 1 SP-RING-type zinc finger

uniprot_information:
SwissProt: Q8NF64 # The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein# Contains 1 SP-RING-type zinc finger


uniprot_information_type: SwissProt: P62937
uniprot_information:
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily &  Contains 1 PPIase cyclophilin-type domain


uniprot_information_type:
SwissProt: Q13422 # The N-terminal zinc-fingers 2 and 3 are required for DNA binding as well as for targeting IKFZ1 to pericentromeric heterochromatin (By similarity) &  The C-terminal zinc-finger domain is required for dimerization (By similarity)# Belongs to the Ikaros C2H2-type zinc-finger protein family &  Contains 6 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q13422 # The N-terminal zinc-fingers 2 and 3 are required for DNA binding as well as for targeting IKFZ1 to pericentromeric heterochromatin (By similarity) &  The C-terminal zinc-finger domain is required for dimerization (By similarity)# Belongs to the Ikaros C2H2-type zinc-finger protein family &  Contains 6 C2H2-type zinc fingers


uniprot_information_type: SwissProt: Q14593
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 13 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: O00144 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain

uniprot_information:
SwissProt: O00144 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain


uniprot_information_type: SwissProt: P53667
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 2 LIM zinc-binding domains &  Contains 1 PDZ (DHR) domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9UHL9 # The N-terminal half may have an activating activity# Belongs to the TFII-I family &  Contains 5 GTF2I-like repeats

uniprot_information:
SwissProt: Q9UHL9 # The N-terminal half may have an activating activity# Belongs to the TFII-I family &  Contains 5 GTF2I-like repeats


uniprot_information_type: SwissProt: P16435
uniprot_information:
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family &  Contains 1 FAD-binding FR-type domain &  Contains 1 flavodoxin-like domain


uniprot_information_type:
SwissProt: Q86UW9 # The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases (By similarity)# Belongs to the Deltex family &  Contains 1 RING-type zinc finger &  Contains 2 WWE domains

uniprot_information:
SwissProt: Q86UW9 # The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases (By similarity)# Belongs to the Deltex family &  Contains 1 RING-type zinc finger &  Contains 2 WWE domains


uniprot_information_type: SwissProt: Q9Y222
uniprot_information:
Belongs to the DMTF1 family &  Contains 1 HTH myb-type DNA-binding domain &  Contains 2 Myb-like domains


uniprot_information_type:
SwissProt: Q9UP38 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain

uniprot_information:
SwissProt: Q9UP38 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain


uniprot_information_type:
SwissProt: Q99996 # RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer#

uniprot_information:
SwissProt: Q99996 # RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer#


uniprot_information_type:
SwissProt: Q9ULJ8 # Interacts with p70-S6K via its PDZ domain (By similarity)# Contains 1 PDZ (DHR) domain &  Contains 1 SAM (sterile alpha motif) domain

uniprot_information:
SwissProt: Q9ULJ8 # Interacts with p70-S6K via its PDZ domain (By similarity)# Contains 1 PDZ (DHR) domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: Q9Y574 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q9Y574 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q8IWU2
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9Y4A5 # The PI3K/PI4K domain is required for the recruitment of HAT complexes, and the MYC-dependent transactivation. Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, and lacks such activity# Belongs to the PI3/PI4-kinase family. TRA1 subfamily &  Contains 1 FAT domain &  Contains 1 FATC domain &  Contains 1 PI3K/PI4K domain

uniprot_information:
SwissProt: Q9Y4A5 # The PI3K/PI4K domain is required for the recruitment of HAT complexes, and the MYC-dependent transactivation. Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, and lacks such activity# Belongs to the PI3/PI4-kinase family. TRA1 subfamily &  Contains 1 FAT domain &  Contains 1 FATC domain &  Contains 1 PI3K/PI4K domain


uniprot_information_type: SwissProt: O95639
uniprot_information:
Belongs to the CPSF4/YTH1 family &  Contains 5 C3H1-type zinc fingers &  Contains 1 CCHC-type zinc finger


uniprot_information_type: SwissProt: P17029
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 6 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type:
SwissProt: O00189 # Interacts specifically with tyrosine-based sorting signals# Belongs to the adaptor complexes medium subunit family &  Contains 1 MHD (mu homology) domain

uniprot_information:
SwissProt: O00189 # Interacts specifically with tyrosine-based sorting signals# Belongs to the adaptor complexes medium subunit family &  Contains 1 MHD (mu homology) domain


uniprot_information_type:
SwissProt: Q9UKJ1 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. PTPN6 seems to bind predominantly to the first ITIM motif# Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q9UKJ1 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. PTPN6 seems to bind predominantly to the first ITIM motif# Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q15654 # The LIM zinc-binding domains mediate interaction with LPAR2 and with S.typhimurium protein sseI# Belongs to the zyxin/ajuba family &  Contains 3 LIM zinc-binding domains

uniprot_information:
SwissProt: Q15654 # The LIM zinc-binding domains mediate interaction with LPAR2 and with S.typhimurium protein sseI# Belongs to the zyxin/ajuba family &  Contains 3 LIM zinc-binding domains


uniprot_information_type: P39880
uniprot_information:
Belongs to the CUT homeobox family &  Contains 3 CUT DNA-binding domains &  Contains 1 homeobox DNA-binding domain


uniprot_information_type: SwissProt: Q9H3W5
uniprot_information:
Contains 1 fibronectin type-III domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 12 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q9P1T7 # The cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm# Belongs to the MDFI family

uniprot_information:
SwissProt: Q9P1T7 # The cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm# Belongs to the MDFI family


uniprot_information_type:
SwissProt: Q9UGI8 # The N-terminal and the C-terminal halves of the protein can asociate with each other, thereby hindering interactions with ZYX# Belongs to the prickle / espinas / testin family &  Contains 3 LIM zinc-binding domains &  Contains 1 PET domain

uniprot_information:
SwissProt: Q9UGI8 # The N-terminal and the C-terminal halves of the protein can asociate with each other, thereby hindering interactions with ZYX# Belongs to the prickle / espinas / testin family &  Contains 3 LIM zinc-binding domains &  Contains 1 PET domain


uniprot_information_type:
SwissProt: P08581 # The kinase domain is involved in SPSB1 binding# Belongs to the protein kinase superfamily. Tyr protein kinase family &  Contains 3 IPT/TIG domains &  Contains 1 protein kinase domain &  Contains 1 Sema domain

uniprot_information:
SwissProt: P08581 # The kinase domain is involved in SPSB1 binding# Belongs to the protein kinase superfamily. Tyr protein kinase family &  Contains 3 IPT/TIG domains &  Contains 1 protein kinase domain &  Contains 1 Sema domain


uniprot_information_type:
SwissProt: P13569 # The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex# Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily &  Contains 2 ABC transmembrane type-1 domains &  Contains 2 ABC transporter domains

uniprot_information:
SwissProt: P13569 # The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex# Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily &  Contains 2 ABC transmembrane type-1 domains &  Contains 2 ABC transporter domains


uniprot_information_type:
SwissProt: Q9NZV8 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily

uniprot_information:
SwissProt: Q9NZV8 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily


uniprot_information_type:
SwissProt: Q14315 # The intradomain insert is specific to FLNC and mediates the targeting to developing and mature Z-disks &  Comprised of a NH2-terminal actin-binding domain, 24 internally homologous repeats and two hinge regions. Repeat 24 and the second hinge domain are important for dimer formation &  The filamin 20 repeat mediates interaction with XIRP1# Belongs to the filamin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 24 filamin repeats

uniprot_information:
SwissProt: Q14315 # The intradomain insert is specific to FLNC and mediates the targeting to developing and mature Z-disks &  Comprised of a NH2-terminal actin-binding domain, 24 internally homologous repeats and two hinge regions. Repeat 24 and the second hinge domain are important for dimer formation &  The filamin 20 repeat mediates interaction with XIRP1# Belongs to the filamin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 24 filamin repeats


uniprot_information_type:
SwissProt: Q05682 # The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form# Belongs to the caldesmon family

uniprot_information:
SwissProt: Q05682 # The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form# Belongs to the caldesmon family


uniprot_information_type: SwissProt: O15164
uniprot_information:
Contains 2 B box-type zinc fingers &  Contains 1 bromo domain &  Contains 1 PHD-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: O15197 # The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2# Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily &  Contains 2 fibronectin type-III domains &  Contains 1 protein kinase domain &  Contains 1 SAM (sterile alpha motif) domain

uniprot_information:
SwissProt: O15197 # The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2# Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily &  Contains 2 fibronectin type-III domains &  Contains 1 protein kinase domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type: SwissProt: Q9UHC6
uniprot_information:
Belongs to the neurexin family &  Contains 2 EGF-like domains &  Contains 1 F5/8 type C domain &  Contains 1 fibrinogen C-terminal domain &  Contains 4 laminin G-like domains


uniprot_information_type: SwissProt: Q9UDV7
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: Q9UDV6
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 4 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: P29474
uniprot_information:
Belongs to the NOS family &  Contains 1 FAD-binding FR-type domain &  Contains 1 flavodoxin-like domain


uniprot_information_type: SwissProt: Q9NUT2
uniprot_information:
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily &  Contains 1 ABC transmembrane type-1 domain &  Contains 1 ABC transporter domain


uniprot_information_type:
SwissProt: Q9UHC3 # The PDZ domain-binding motif is involved in interaction with LIN7A, GOPC and MAGI1# Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN3 subfamily

uniprot_information:
SwissProt: Q9UHC3 # The PDZ domain-binding motif is involved in interaction with LIN7A, GOPC and MAGI1# Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ACCN3 subfamily


uniprot_information_type:
SwissProt: Q8NCW6 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q8NCW6 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: Q15386 # The C-terminal is necessary and sufficient for the poly-ubiquitin chain assembly# Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 1 IQ domain

uniprot_information:
SwissProt: Q15386 # The C-terminal is necessary and sufficient for the poly-ubiquitin chain assembly# Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 1 IQ domain


uniprot_information_type:
SwissProt: O60496 # PTB domain mediates receptor interaction# Belongs to the DOK family. Type A subfamily &  Contains 1 IRS-type PTB domain &  Contains 1 PH domain

uniprot_information:
SwissProt: O60496 # PTB domain mediates receptor interaction# Belongs to the DOK family. Type A subfamily &  Contains 1 IRS-type PTB domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: P07196 # The extra mass and high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions# Belongs to the intermediate filament family

uniprot_information:
SwissProt: P07196 # The extra mass and high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions# Belongs to the intermediate filament family


uniprot_information_type: SwissProt: Q15822
uniprot_information:
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-2/CHRNA2 sub-subfamily


uniprot_information_type: SwissProt: Q96KB5
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9NV88
uniprot_information:
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily


uniprot_information_type: SwissProt: Q9NQT8
uniprot_information:
Belongs to the kinesin-like protein family &  Contains 1 CAP-Gly domain &  Contains 1 FHA domain &  Contains 1 kinesin-motor domain


uniprot_information_type:
SwissProt: P00390 # Each subunit can be divided into 4 domains that are consecutive along the polypeptide chain. Domains 1 and 2 bind FAD and NADPH, respectively. Domain 4 forms the interface# Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family

uniprot_information:
SwissProt: P00390 # Each subunit can be divided into 4 domains that are consecutive along the polypeptide chain. Domains 1 and 2 bind FAD and NADPH, respectively. Domain 4 forms the interface# Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family


uniprot_information_type: SwissProt: Q9BZ95
uniprot_information:
Belongs to the histone-lysine methyltransferase family. SET2 subfamily &  Contains 1 AWS domain &  Contains 4 PHD-type zinc fingers &  Contains 1 post-SET domain &  Contains 2 PWWP domains &  Contains 1 SET domain


uniprot_information_type:
SwissProt: Q99965 # A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: Q99965 # A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain


uniprot_information_type:
SwissProt: Q8N474 # The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the secreted frizzled-related protein (sFRP) family &  Contains 1 FZ (frizzled) domain &  Contains 1 NTR domain

uniprot_information:
SwissProt: Q8N474 # The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the secreted frizzled-related protein (sFRP) family &  Contains 1 FZ (frizzled) domain &  Contains 1 NTR domain


uniprot_information_type:
SwissProt: P16157 # The 55 kDa regulatory domain is involved in regulating binding of SPTB/spectrin (beta chain) and SLC4A1/erythrocyte membrane protein band 3 &  The ANK repeat region forms a spiral around a large central cavity and is involved in binding of ion transporters# Contains 23 ANK repeats &  Contains 1 death domain &  Contains 1 ZU5 domain

uniprot_information:
SwissProt: P16157 # The 55 kDa regulatory domain is involved in regulating binding of SPTB/spectrin (beta chain) and SLC4A1/erythrocyte membrane protein band 3 &  The ANK repeat region forms a spiral around a large central cavity and is involved in binding of ion transporters# Contains 23 ANK repeats &  Contains 1 death domain &  Contains 1 ZU5 domain


uniprot_information_type:
SwissProt: Q92794 # The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression# Belongs to the MYST (SAS/MOZ) family &  Contains 1 C2HC-type zinc finger &  Contains 2 PHD-type zinc fingers

uniprot_information:
SwissProt: Q92794 # The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression# Belongs to the MYST (SAS/MOZ) family &  Contains 1 C2HC-type zinc finger &  Contains 2 PHD-type zinc fingers


uniprot_information_type:
SwissProt: P00750 # Both FN1 and one of the kringle domains are required for binding to fibrin &  Both FN1 and EGF-like domains are important for binding to LRP1 &  The FN1 domain mediates binding to annexin A2 &  The second kringle domain is implicated in binding to cytokeratin-8 and to the endothelial cell surface binding site# Belongs to the peptidase S1 family &  Contains 1 EGF-like domain &  Contains 1 fibronectin type-I domain &  Contains 2 kringle domains &  Contains 1 peptidase S1 domain

uniprot_information:
SwissProt: P00750 # Both FN1 and one of the kringle domains are required for binding to fibrin &  Both FN1 and EGF-like domains are important for binding to LRP1 &  The FN1 domain mediates binding to annexin A2 &  The second kringle domain is implicated in binding to cytokeratin-8 and to the endothelial cell surface binding site# Belongs to the peptidase S1 family &  Contains 1 EGF-like domain &  Contains 1 fibronectin type-I domain &  Contains 2 kringle domains &  Contains 1 peptidase S1 domain


uniprot_information_type:
SwissProt: Q9UBT3 # The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)# Belongs to the dickkopf family

uniprot_information:
SwissProt: Q9UBT3 # The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)# Belongs to the dickkopf family


uniprot_information_type: SwissProt: Q15825
uniprot_information:
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-6/CHRNA6 sub-subfamily


uniprot_information_type: SwissProt: P78527
uniprot_information:
Belongs to the PI3/PI4-kinase family &  Contains 1 FAT domain &  Contains 1 FATC domain &  Contains 2 HEAT repeats &  Contains 1 PI3K/PI4K domain &  Contains 3 TPR repeats


uniprot_information_type: SwissProt: P23193
uniprot_information:
Belongs to the TFS-II family &  Contains 1 TFIIS central domain &  Contains 1 TFIIS N-terminal domain &  Contains 1 TFIIS-type zinc finger


uniprot_information_type:
SwissProt: Q6DJT9 # C2H2-type zinc fingers 3 interacts with DNA-binding site G-clusterinc fingers. C2H2-type zinc fingers 6 and 7 interact with DNA-binding site core sequence# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 7 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q6DJT9 # C2H2-type zinc fingers 3 interacts with DNA-binding site G-clusterinc fingers. C2H2-type zinc fingers 6 and 7 interact with DNA-binding site core sequence# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 7 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q92905 # The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity)# Belongs to the peptidase M67A family. CSN5 subfamily &  Contains 1 MPN (JAB/Mov34) domain

uniprot_information:
SwissProt: Q92905 # The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity)# Belongs to the peptidase M67A family. CSN5 subfamily &  Contains 1 MPN (JAB/Mov34) domain


uniprot_information_type: SwissProt: Q8IVN8
uniprot_information:
Belongs to the thrombospondin family &  Contains 1 SMB (somatomedin-B) domain &  Contains 1 TSP type-1 domain


uniprot_information_type:
SwissProt: Q9NUL3 # The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity)# Contains 4 DRBM (double-stranded RNA-binding) domains

uniprot_information:
SwissProt: Q9NUL3 # The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity)# Contains 4 DRBM (double-stranded RNA-binding) domains


uniprot_information_type:
SwissProt: P02689 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior (By similarity)# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

uniprot_information:
SwissProt: P02689 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior (By similarity)# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


uniprot_information_type:
SwissProt: P15090 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

uniprot_information:
SwissProt: P15090 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


uniprot_information_type: SwissProt: Q9NQW8
uniprot_information:
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB3 subfamily &  Contains 1 cyclic nucleotide-binding domain


uniprot_information_type:
SwissProt: P51512 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: P51512 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: O60934 # The FHA and BRCT domains are likely to have a crucial role for both binding to histone H2AFX and for relocalization of MRE11/RAD50 complex to the vicinity of DNA damage &  The C-terminal domain contains a MRE11-binding site, and this interaction is required for the nuclear localization of the MRN complex &  The EEXXXDDL motif at the C-terminus is required for the interaction with ATM and its recruitment to sites of DNA damage and promote the phosphorylation of ATM substrates, leading to the events of DNA damage response# Contains 1 BRCT domain &  Contains 1 FHA domain

uniprot_information:
SwissProt: O60934 # The FHA and BRCT domains are likely to have a crucial role for both binding to histone H2AFX and for relocalization of MRE11/RAD50 complex to the vicinity of DNA damage &  The C-terminal domain contains a MRE11-binding site, and this interaction is required for the nuclear localization of the MRN complex &  The EEXXXDDL motif at the C-terminus is required for the interaction with ATM and its recruitment to sites of DNA damage and promote the phosphorylation of ATM substrates, leading to the events of DNA damage response# Contains 1 BRCT domain &  Contains 1 FHA domain


uniprot_information_type:
SwissProt: P05937 # This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium# Belongs to the calbindin family &  Contains 5 EF-hand domains

uniprot_information:
SwissProt: P05937 # This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium# Belongs to the calbindin family &  Contains 5 EF-hand domains


uniprot_information_type:
SwissProt: Q06455 # The TAFH domain mediates interaction with transcription regulators# Belongs to the CBFA2T family &  Contains 1 MYND-type zinc finger &  Contains 1 TAFH (NHR1) domain

uniprot_information:
SwissProt: Q06455 # The TAFH domain mediates interaction with transcription regulators# Belongs to the CBFA2T family &  Contains 1 MYND-type zinc finger &  Contains 1 TAFH (NHR1) domain


uniprot_information_type: SwissProt: Q13188
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 protein kinase domain &  Contains 1 SARAH domain


uniprot_information_type: SwissProt: Q9NV58
uniprot_information:
Belongs to the RBR family. RNF19 subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers


uniprot_information_type:
SwissProt: P11940 # The RNA-binding domains RRM1 and RRM2 and the C-terminus (last 138 amino acids) regions interact with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1, respectively &  The RNA-binding domains RRM2 and RRM3 and the C-terminus (last 138 amino acids) regions interact with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP2, respectively# Belongs to the polyadenylate-binding protein type-1 family &  Contains 1 PABC domain &  Contains 4 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: P11940 # The RNA-binding domains RRM1 and RRM2 and the C-terminus (last 138 amino acids) regions interact with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1, respectively &  The RNA-binding domains RRM2 and RRM3 and the C-terminus (last 138 amino acids) regions interact with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP2, respectively# Belongs to the polyadenylate-binding protein type-1 family &  Contains 1 PABC domain &  Contains 4 RRM (RNA recognition motif) domains


uniprot_information_type: SwissProt: O95071
uniprot_information:
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 1 PABC domain &  Contains 1 UBR-type zinc finger


uniprot_information_type:
SwissProt: Q6PIU1 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily

uniprot_information:
SwissProt: Q6PIU1 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily


uniprot_information_type:
SwissProt: O60216 # The C-terminal part associates with the head of SMC1A, while the N-terminal part binds to the head of SMC3 (By similarity)# Belongs to the rad21 family

uniprot_information:
SwissProt: O60216 # The C-terminal part associates with the head of SMC1A, while the N-terminal part binds to the head of SMC3 (By similarity)# Belongs to the rad21 family


uniprot_information_type: SwissProt: Q13822
uniprot_information:
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family &  Contains 2 SMB (somatomedin-B) domains


uniprot_information_type:
SwissProt: Q13884 # The PH 1 domain mediates the oligomerization in a calcium dependent manner (By similarity) &  The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity) &  The SU domain binds calmodulin in a calcium-dependent manner (By similarity)# Belongs to the syntrophin family &  Contains 1 PDZ (DHR) domain &  Contains 2 PH domains &  Contains 1 SU (syntrophin unique) domain

uniprot_information:
SwissProt: Q13884 # The PH 1 domain mediates the oligomerization in a calcium dependent manner (By similarity) &  The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity) &  The SU domain binds calmodulin in a calcium-dependent manner (By similarity)# Belongs to the syntrophin family &  Contains 1 PDZ (DHR) domain &  Contains 2 PH domains &  Contains 1 SU (syntrophin unique) domain


uniprot_information_type:
SwissProt: P27216 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats

uniprot_information:
SwissProt: P27216 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats


uniprot_information_type:
SwissProt: O43312 # The WH2 motif at the C-terminus binds to actin monomers# Belongs to the MTSS1 family &  Contains 1 IMD (IRSp53/MIM homology) domain &  Contains 1 WH2 domain

uniprot_information:
SwissProt: O43312 # The WH2 motif at the C-terminus binds to actin monomers# Belongs to the MTSS1 family &  Contains 1 IMD (IRSp53/MIM homology) domain &  Contains 1 WH2 domain


uniprot_information_type:
SwissProt: Q9ULH1 # The PH domain most probably contributes to the phosphoinositide-dependent regulation of ADP ribosylation factors (By similarity)# Contains 2 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 PH domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q9ULH1 # The PH domain most probably contributes to the phosphoinositide-dependent regulation of ADP ribosylation factors (By similarity)# Contains 2 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 PH domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: O43525 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily

uniprot_information:
SwissProt: O43525 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily


uniprot_information_type:
SwissProt: Q13239 # The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization# Contains 1 SH2 domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q13239 # The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization# Contains 1 SH2 domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q05397 # The first Pro-rich domain interacts with the SH3 domain of CRK-associated substrate (BCAR1) and CASL (By similarity) &  The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions# Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily &  Contains 1 FERM domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q05397 # The first Pro-rich domain interacts with the SH3 domain of CRK-associated substrate (BCAR1) and CASL (By similarity) &  The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions# Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily &  Contains 1 FERM domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O75564
uniprot_information:
Belongs to the tigger transposable element derived protein family &  Contains 1 DDE domain &  Contains 1 HTH CENPB-type DNA-binding domain


uniprot_information_type: SwissProt: Q14160
uniprot_information:
Belongs to the LAP (LRR and PDZ) protein family &  Contains 16 LRR (leucine-rich) repeats &  Contains 4 PDZ (DHR) domains


uniprot_information_type:
SwissProt: Q9UHX1 # The third RNA recognition motif, called PUMP domain, is atypical and may rather mediate homodimerization and/or protein-protein interactions# Belongs to the RRM half pint family &  Contains 3 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: Q9UHX1 # The third RNA recognition motif, called PUMP domain, is atypical and may rather mediate homodimerization and/or protein-protein interactions# Belongs to the RRM half pint family &  Contains 3 RRM (RNA recognition motif) domains


uniprot_information_type:
SwissProt: Q15149 # The N-terminus interacts with actin, the C-terminus with vimentin, desmin, GFAP, cytokeratins, lamin B; whereas both the N- and the C-terminus can bind integrin beta-4# Belongs to the plakin or cytolinker family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 33 plectin repeats &  Contains 4 spectrin repeats

uniprot_information:
SwissProt: Q15149 # The N-terminus interacts with actin, the C-terminus with vimentin, desmin, GFAP, cytokeratins, lamin B; whereas both the N- and the C-terminus can bind integrin beta-4# Belongs to the plakin or cytolinker family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 33 plectin repeats &  Contains 4 spectrin repeats


uniprot_information_type:
SwissProt: Q9BWW7 # The N-terminal non zinc-finger region mediates the repressor activity# Belongs to the snail C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q9BWW7 # The N-terminal non zinc-finger region mediates the repressor activity# Belongs to the snail C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers


uniprot_information_type: SwissProt: Q9UK41
uniprot_information:
Belongs to the VPS28 family &  Contains 1 VPS28 C-terminal domain &  Contains 1 VPS28 N-terminal domain


uniprot_information_type:
SwissProt: O75593 # The FM region is required for binding SMAD2/SMAD4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated SMAD2 that is in an activated SMAD complex (By similarity)# Contains 1 fork-head DNA-binding domain

uniprot_information:
SwissProt: O75593 # The FM region is required for binding SMAD2/SMAD4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated SMAD2 that is in an activated SMAD complex (By similarity)# Contains 1 fork-head DNA-binding domain


uniprot_information_type: SwissProt: Q8IZ26
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 12 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q9NUQ2 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

uniprot_information:
SwissProt: Q9NUQ2 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


uniprot_information_type: SwissProt: O95271
uniprot_information:
Contains 15 ANK repeats &  Contains 1 PARP catalytic domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type: SwissProt: P52569
uniprot_information:
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family


uniprot_information_type:
SwissProt: Q08495 # Contains at least two actin-binding sites, one in the headpiece domain and one in the amino-terminal portion &  Consists of a large core fragment, the amino-terminal portion, and a small headpiece, the C-terminal portion. The headpiece can bind but cannot bundle actin filaments# Belongs to the villin/gelsolin family &  Contains 1 HP (headpiece) domain

uniprot_information:
SwissProt: Q08495 # Contains at least two actin-binding sites, one in the headpiece domain and one in the amino-terminal portion &  Consists of a large core fragment, the amino-terminal portion, and a small headpiece, the C-terminal portion. The headpiece can bind but cannot bundle actin filaments# Belongs to the villin/gelsolin family &  Contains 1 HP (headpiece) domain


uniprot_information_type:
SwissProt: Q9UKQ2 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: Q9UKQ2 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain


uniprot_information_type:
SwissProt: Q9H7D0 # The DHR-2 domain may mediate some GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q9H7D0 # The DHR-2 domain may mediate some GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: Q14289
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily &  Contains 1 FERM domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P34913 # The N-terminal domain has phosphatase activity. The C-terminal domain has epoxide hydrolase activity# Belongs to the AB hydrolase superfamily. Epoxide hydrolase family

uniprot_information:
SwissProt: P34913 # The N-terminal domain has phosphatase activity. The C-terminal domain has epoxide hydrolase activity# Belongs to the AB hydrolase superfamily. Epoxide hydrolase family


uniprot_information_type:
SwissProt: Q9NPG1 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain

uniprot_information:
SwissProt: Q9NPG1 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain


uniprot_information_type:
SwissProt: Q93062 # The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity# Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q93062 # The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity# Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type: SwissProt: Q14191
uniprot_information:
Belongs to the helicase family. RecQ subfamily &  Contains 1 3'-5' exonuclease domain &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 HRDC domain


uniprot_information_type:
SwissProt: Q02297 # The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity) &  ERBB receptor binding is elicited entirely by the EGF-like domain# Belongs to the neuregulin family &  Contains 1 EGF-like domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q02297 # The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity) &  ERBB receptor binding is elicited entirely by the EGF-like domain# Belongs to the neuregulin family &  Contains 1 EGF-like domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q96PE1 # Binds to DLG1 through its PDZ-binding motif# Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 1 GPS domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 5 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q96PE1 # Binds to DLG1 through its PDZ-binding motif# Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 1 GPS domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 5 LRR (leucine-rich) repeats


uniprot_information_type: SwissProt: O94830
uniprot_information:
Belongs to the PA-PLA1 family &  Contains 1 DDHD domain &  Contains 1 SAM (sterile alpha motif) domain &  Contains 1 WWE domain


uniprot_information_type:
SwissProt: Q9Y3Q7 # A tripeptide motif (ECD) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding (By similarity)# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: Q9Y3Q7 # A tripeptide motif (ECD) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding (By similarity)# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain


uniprot_information_type:
SwissProt: P06746 # Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity (By similarity)# Belongs to the DNA polymerase type-X family

uniprot_information:
SwissProt: P06746 # Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity (By similarity)# Belongs to the DNA polymerase type-X family


uniprot_information_type:
SwissProt: Q9Y277 # Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands (By similarity)# Belongs to the eukaryotic mitochondrial porin family

uniprot_information:
SwissProt: Q9Y277 # Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands (By similarity)# Belongs to the eukaryotic mitochondrial porin family


uniprot_information_type: SwissProt: Q05901
uniprot_information:
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub-subfamily


uniprot_information_type:
SwissProt: P07948 # The protein kinase domain plays an important role in its localization in the cell membrane# Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily &  Contains 1 protein kinase domain &  Contains 1 SH2 domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: P07948 # The protein kinase domain plays an important role in its localization in the cell membrane# Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily &  Contains 1 protein kinase domain &  Contains 1 SH2 domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: Q9P2D1
uniprot_information:
Belongs to the SNF2/RAD54 helicase family &  Contains 2 chromo domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: Q96BR1
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain &  Contains 1 PX (phox homology) domain


uniprot_information_type:
SwissProt: Q70Z35 # PH domain confers substrate specificity and recognition. Able to discriminate between RAC1, RHOA, and CDC42 &  DH domain alone was unable to confer substrate specificity and recognition# Contains 2 DEP domains &  Contains 1 DH (DBL-homology) domain &  Contains 2 PDZ (DHR) domains &  Contains 1 PH domain

uniprot_information:
SwissProt: Q70Z35 # PH domain confers substrate specificity and recognition. Able to discriminate between RAC1, RHOA, and CDC42 &  DH domain alone was unable to confer substrate specificity and recognition# Contains 2 DEP domains &  Contains 1 DH (DBL-homology) domain &  Contains 2 PDZ (DHR) domains &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q92953 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily

uniprot_information:
SwissProt: Q92953 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily


uniprot_information_type:
SwissProt: P54274 # The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules# Contains 1 HTH myb-type DNA-binding domain

uniprot_information:
SwissProt: P54274 # The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules# Contains 1 HTH myb-type DNA-binding domain


uniprot_information_type: SwissProt: Q8TB36
uniprot_information:
Belongs to the GST superfamily &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain


uniprot_information_type: SwissProt: Q86UP3
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 20 C2H2-type zinc fingers &  Contains 4 homeobox DNA-binding domains


uniprot_information_type: SwissProt: Q9H0M0
uniprot_information:
Contains 1 C2 domain &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 4 WW domains


uniprot_information_type: SwissProt: O43353
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 1 CARD domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q16698
uniprot_information:
Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily


uniprot_information_type: SwissProt: Q9BZK3
uniprot_information:
Belongs to the NAC-alpha family &  Contains 1 NAC-A/B (NAC-alpha/beta) domain &  Contains 1 UBA domain


uniprot_information_type:
SwissProt: O60353 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain

uniprot_information:
SwissProt: O60353 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain


uniprot_information_type:
SwissProt: Q8WW38 # The CCHC-type zinc fingers 1, 5, 6 and 8 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity)# Belongs to the FOG (Friend of GATA) family &  Contains 3 C2H2-type zinc fingers &  Contains 5 C2HC-type zinc fingers

uniprot_information:
SwissProt: Q8WW38 # The CCHC-type zinc fingers 1, 5, 6 and 8 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity)# Belongs to the FOG (Friend of GATA) family &  Contains 3 C2H2-type zinc fingers &  Contains 5 C2HC-type zinc fingers


uniprot_information_type: SwissProt: Q8N573
uniprot_information:
Belongs to the OXR1 family &  Contains 1 GRAM domain &  Contains 1 LysM repeat &  Contains 1 TLD domain


uniprot_information_type: SwissProt: Q05707
uniprot_information:
Belongs to the fibril-associated collagens with interrupted helices (FACIT) family &  Contains 8 fibronectin type-III domains &  Contains 1 TSP N-terminal (TSPN) domain &  Contains 2 VWFA domains


uniprot_information_type: SwissProt: Q9Y6X8
uniprot_information:
Belongs to the ZHX family &  Contains 2 C2H2-type zinc fingers &  Contains 4 homeobox DNA-binding domains


uniprot_information_type:
SwissProt: Q8WU17 # The RING-type zinc finger domain mediates ubiquitin ligase activity# Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8WU17 # The RING-type zinc finger domain mediates ubiquitin ligase activity# Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: O75525 # The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase# Belongs to the KHDRBS family &  Contains 1 KH domain

uniprot_information:
SwissProt: O75525 # The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase# Belongs to the KHDRBS family &  Contains 1 KH domain


uniprot_information_type: SwissProt: A2RUS2
uniprot_information:
Contains 1 dDENN domain &  Contains 1 DENN domain &  Contains 1 uDENN domain &  Contains 3 WD repeats


uniprot_information_type: SwissProt: P24298
uniprot_information:
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily


uniprot_information_type: SwissProt: P17097
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 15 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q15397 # The HA-8 region can be cleaved and exposed at the cell surface where it plays a role as a minor histocompatibility HLA-A*0201-restricted antigen# Contains 1 PUM-HD domain &  Contains 6 pumilio repeats

uniprot_information:
SwissProt: Q15397 # The HA-8 region can be cleaved and exposed at the cell surface where it plays a role as a minor histocompatibility HLA-A*0201-restricted antigen# Contains 1 PUM-HD domain &  Contains 6 pumilio repeats


uniprot_information_type:
SwissProt: O75970 # The PDZ domain 1 binds NG2. The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT and the C-terminal PDZ-binding motif of HTR2C. The PDZ domain 13 binds CXADR (By similarity). The PDZ domain 2 binds CAMK2A and CAMK2B. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds SYNGAP1# Contains 1 L27 domain &  Contains 13 PDZ (DHR) domains

uniprot_information:
SwissProt: O75970 # The PDZ domain 1 binds NG2. The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT and the C-terminal PDZ-binding motif of HTR2C. The PDZ domain 13 binds CXADR (By similarity). The PDZ domain 2 binds CAMK2A and CAMK2B. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds SYNGAP1# Contains 1 L27 domain &  Contains 13 PDZ (DHR) domains


uniprot_information_type:
SwissProt: O75475 # Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain)# Belongs to the HDGF family &  Contains 1 PWWP domain

uniprot_information:
SwissProt: O75475 # Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain)# Belongs to the HDGF family &  Contains 1 PWWP domain


uniprot_information_type: SwissProt: Q9Y263
uniprot_information:
Belongs to the WD repeat PLAP family &  Contains 1 PFU domain &  Contains 1 PUL domain &  Contains 7 WD repeats


uniprot_information_type:
SwissProt: O95786 # The repressor domain controls homomultimerization and interaction with MAVS (Probable) &  The helicase domain is responsible for dsRNA recognition &  The 2 CARD domains are responsible for interaction with and signaling through MAVS &  The second CARD domain is the primary site for 'Lys-63'-linked ubiquitination# Belongs to the helicase family &  Contains 2 CARD domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain

uniprot_information:
SwissProt: O95786 # The repressor domain controls homomultimerization and interaction with MAVS (Probable) &  The helicase domain is responsible for dsRNA recognition &  The 2 CARD domains are responsible for interaction with and signaling through MAVS &  The second CARD domain is the primary site for 'Lys-63'-linked ubiquitination# Belongs to the helicase family &  Contains 2 CARD domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q7Z2E3 # The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide (By similarity) &  The FHA-like domain mediates interaction with NCL; XRCC1 and XRCC4 &  The HIT domain is required for enzymatic activity &  The C2H2-type zinc finger mediates DNA-binding# Contains 1 C2H2-type zinc finger &  Contains 1 FHA-like domain &  Contains 1 HIT domain

uniprot_information:
SwissProt: Q7Z2E3 # The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide (By similarity) &  The FHA-like domain mediates interaction with NCL; XRCC1 and XRCC4 &  The HIT domain is required for enzymatic activity &  The C2H2-type zinc finger mediates DNA-binding# Contains 1 C2H2-type zinc finger &  Contains 1 FHA-like domain &  Contains 1 HIT domain


uniprot_information_type: SwissProt: Q2TAY7
uniprot_information:
Belongs to the WD repeat SMU1 family &  Contains 1 CTLH domain &  Contains 1 LisH domain &  Contains 6 WD repeats


uniprot_information_type:
SwissProt: O14520 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family

uniprot_information:
SwissProt: O14520 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family


uniprot_information_type:
SwissProt: Q92482 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family

uniprot_information:
SwissProt: Q92482 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family


uniprot_information_type: SwissProt: Q5T7B8
uniprot_information:
Belongs to the kinesin-like protein family &  Contains 1 kinesin-motor domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: P26992 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding# Belongs to the type I cytokine receptor family. Type 3 subfamily &  Contains 2 fibronectin type-III domains &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: P26992 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding# Belongs to the type I cytokine receptor family. Type 3 subfamily &  Contains 2 fibronectin type-III domains &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: P07951 # The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity# Belongs to the tropomyosin family

uniprot_information:
SwissProt: P07951 # The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity# Belongs to the tropomyosin family


uniprot_information_type: SwissProt: Q9Y223
uniprot_information:
In the N-terminal section; belongs to the UDP-N-acetylglucosamine 2-epimerase family &  In the C-terminal section; belongs to the ROK (nagC/xylR) family


uniprot_information_type:
SwissProt: Q15464 # The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII# Contains 1 SH2 domain

uniprot_information:
SwissProt: Q15464 # The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII# Contains 1 SH2 domain


uniprot_information_type:
SwissProt: Q02410 # Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane# Contains 2 PDZ (DHR) domains &  Contains 1 PID domain

uniprot_information:
SwissProt: Q02410 # Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane# Contains 2 PDZ (DHR) domains &  Contains 1 PID domain


uniprot_information_type:
SwissProt: O76080 # The A20-type zinc finger directly binds polyubiquitin chains and associates with the 26S proteasome. The zinc-finger A20-type domain is essential for inhibition of NF-kappa-B activation (By similarity)# Contains 1 A20-type zinc finger &  Contains 1 AN1-type zinc finger

uniprot_information:
SwissProt: O76080 # The A20-type zinc finger directly binds polyubiquitin chains and associates with the 26S proteasome. The zinc-finger A20-type domain is essential for inhibition of NF-kappa-B activation (By similarity)# Contains 1 A20-type zinc finger &  Contains 1 AN1-type zinc finger


uniprot_information_type: SwissProt: Q9BX84
uniprot_information:
In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily &  In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily &  Contains 1 alpha-type protein kinase domain


uniprot_information_type: SwissProt: P20774
uniprot_information:
Belongs to the small leucine-rich proteoglycan (SLRP) family. Class III subfamily &  Contains 7 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q9BXN1 # The LRR 5 repeat can inhibit BMP2-induced cytodifferentiation and may be involved in the interaction with BMP2 (By similarity). The repeats LRR 10, LRR 11 and LRR 12 are involved in binding type I collagen. The poly-Asp region is involved in binding calcium# Belongs to the small leucine-rich proteoglycan (SLRP) family. Class I subfamily &  Contains 12 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q9BXN1 # The LRR 5 repeat can inhibit BMP2-induced cytodifferentiation and may be involved in the interaction with BMP2 (By similarity). The repeats LRR 10, LRR 11 and LRR 12 are involved in binding type I collagen. The poly-Asp region is involved in binding calcium# Belongs to the small leucine-rich proteoglycan (SLRP) family. Class I subfamily &  Contains 12 LRR (leucine-rich) repeats


uniprot_information_type: SwissProt: O94769
uniprot_information:
Belongs to the small leucine-rich proteoglycan (SLRP) family. Class I subfamily &  Contains 14 LRR (leucine-rich) repeats &  Contains 1 VWFC domain


uniprot_information_type:
SwissProt: Q9H8X2 # The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2# Belongs to the IPK1 type 2 family

uniprot_information:
SwissProt: Q9H8X2 # The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2# Belongs to the IPK1 type 2 family


uniprot_information_type:
SwissProt: Q8TD16 # The fourth coiled coil region is involved in Golgi targeting and in the interaction with DCTN2 (By similarity)# Belongs to the BicD family

uniprot_information:
SwissProt: Q8TD16 # The fourth coiled coil region is involved in Golgi targeting and in the interaction with DCTN2 (By similarity)# Belongs to the BicD family


uniprot_information_type:
SwissProt: O60729 # Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold# Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily

uniprot_information:
SwissProt: O60729 # Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold# Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily


uniprot_information_type: SwissProt: Q9Y2H8
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 10 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q14142 # The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation (By similarity)# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain

uniprot_information:
SwissProt: Q14142 # The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation (By similarity)# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain


uniprot_information_type:
SwissProt: O75899 # Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1# Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily

uniprot_information:
SwissProt: O75899 # Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 1# Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily


uniprot_information_type:
SwissProt: O95477 # Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain# Belongs to the ABC transporter superfamily. ABCA family &  Contains 2 ABC transporter domains

uniprot_information:
SwissProt: O95477 # Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain# Belongs to the ABC transporter superfamily. ABCA family &  Contains 2 ABC transporter domains


uniprot_information_type: SwissProt: Q4LDE5
uniprot_information:
Contains 9 EGF-like domains &  Contains 2 HYR domains &  Contains 1 pentaxin domain &  Contains 34 Sushi (CCP/SCR) domains &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q5T1M5 # The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity (By similarity) &  The central coiled-coil region is responsible for association with early endosomes# Belongs to the FKBP-type PPIase family &  Contains 1 PPIase FKBP-type domain

uniprot_information:
SwissProt: Q5T1M5 # The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity (By similarity) &  The central coiled-coil region is responsible for association with early endosomes# Belongs to the FKBP-type PPIase family &  Contains 1 PPIase FKBP-type domain


uniprot_information_type: SwissProt: P02760
uniprot_information:
In the N-terminal section; belongs to the calycin superfamily. Lipocalin family &  Contains 2 BPTI/Kunitz inhibitor domains


uniprot_information_type: SwissProt: P24821
uniprot_information:
Belongs to the tenascin family &  Contains 15 EGF-like domains &  Contains 1 fibrinogen C-terminal domain &  Contains 15 fibronectin type-III domains


uniprot_information_type:
SwissProt: Q16401 # Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins# Belongs to the proteasome subunit S5B/HSM3 family

uniprot_information:
SwissProt: Q16401 # Rich in dileucine repeats, which have been implicated in trafficking of a variety of transmembrane proteins# Belongs to the proteasome subunit S5B/HSM3 family


uniprot_information_type:
SwissProt: Q13077 # The coiled coil domain mediates homo- and hetero-oligomerization &  The MATH/TRAF domain binds to receptor cytoplasmic domains# Contains 1 MATH domain

uniprot_information:
SwissProt: Q13077 # The coiled coil domain mediates homo- and hetero-oligomerization &  The MATH/TRAF domain binds to receptor cytoplasmic domains# Contains 1 MATH domain


uniprot_information_type: SwissProt: Q15406
uniprot_information:
Belongs to the nuclear hormone receptor family. NR6 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type: SwissProt: Q9H7Z7
uniprot_information:
Belongs to the GST superfamily &  Contains 1 glutaredoxin domain &  Contains 1 GST C-terminal domain


uniprot_information_type:
SwissProt: Q08379 # Extended rod-like protein with coiled-coil domains# Belongs to the GOLGA2 family

uniprot_information:
SwissProt: Q08379 # Extended rod-like protein with coiled-coil domains# Belongs to the GOLGA2 family


uniprot_information_type:
SwissProt: Q9NWX5 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q9NWX5 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: Q15361 # The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region (By similarity)# Contains 2 Myb-like domains

uniprot_information:
SwissProt: Q15361 # The N-terminal region (NRD) inhibits DNA-binding via its interaction with the C-terminal region (By similarity)# Contains 2 Myb-like domains


uniprot_information_type: SwissProt: Q9H8H2
uniprot_information:
Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q92574 # The C-terminal putative coiled-coil domain is necessary for interaction with TSC2#

uniprot_information:
SwissProt: Q92574 # The C-terminal putative coiled-coil domain is necessary for interaction with TSC2#


uniprot_information_type:
SwissProt: Q12967 # The Ras-associating domain interacts with Ras# Contains 1 N-terminal Ras-GEF domain &  Contains 1 Ras-associating domain &  Contains 1 Ras-GEF domain

uniprot_information:
SwissProt: Q12967 # The Ras-associating domain interacts with Ras# Contains 1 N-terminal Ras-GEF domain &  Contains 1 Ras-associating domain &  Contains 1 Ras-GEF domain


uniprot_information_type:
SwissProt: P16442 # The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis# Belongs to the glycosyltransferase 6 family

uniprot_information:
SwissProt: P16442 # The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis# Belongs to the glycosyltransferase 6 family


uniprot_information_type:
SwissProt: Q5T5Y3 # The CKK domain binds microtubules# Belongs to the CAMSAP1 family &  Contains 1 CH (calponin-homology) domain &  Contains 1 CKK domain

uniprot_information:
SwissProt: Q5T5Y3 # The CKK domain binds microtubules# Belongs to the CAMSAP1 family &  Contains 1 CH (calponin-homology) domain &  Contains 1 CKK domain


uniprot_information_type: SwissProt: P46531
uniprot_information:
Belongs to the NOTCH family &  Contains 5 ANK repeats &  Contains 36 EGF-like domains &  Contains 3 LNR (Lin/Notch) repeats


uniprot_information_type:
SwissProt: O15120 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

uniprot_information:
SwissProt: O15120 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


uniprot_information_type:
SwissProt: O60869 # The IQ motif, which is involved in calmodulin binding, overlaps with the binding domain for nuclear receptors and transcription factors. Its phosphorylation probably allows a switch between the two activities of the protein (By similarity)# Contains 1 HTH cro/C1-type DNA-binding domain

uniprot_information:
SwissProt: O60869 # The IQ motif, which is involved in calmodulin binding, overlaps with the binding domain for nuclear receptors and transcription factors. Its phosphorylation probably allows a switch between the two activities of the protein (By similarity)# Contains 1 HTH cro/C1-type DNA-binding domain


uniprot_information_type:
SwissProt: O95833 # Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity)# Belongs to the chloride channel CLIC family &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain

uniprot_information:
SwissProt: O95833 # Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity)# Belongs to the chloride channel CLIC family &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain


uniprot_information_type: SwissProt: P51531
uniprot_information:
Belongs to the SNF2/RAD54 helicase family &  Contains 1 bromo domain &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 HSA domain


uniprot_information_type: SwissProt: P98155
uniprot_information:
Contains 3 EGF-like domains &  Contains 8 LDL-receptor class A domains &  Contains 6 LDL-receptor class B repeats


uniprot_information_type:
SwissProt: Q8TDN2 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily

uniprot_information:
SwissProt: Q8TDN2 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily


uniprot_information_type:
SwissProt: O60674 # Possesses 2 protein kinase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for protein kinase 1 (By similarity)# Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily &  Contains 1 FERM domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain

uniprot_information:
SwissProt: O60674 # Possesses 2 protein kinase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for protein kinase 1 (By similarity)# Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily &  Contains 1 FERM domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain


uniprot_information_type: SwissProt: Q9BQ51
uniprot_information:
Belongs to the immunoglobulin superfamily. BTN/MOG family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q9H3R0 # The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity)# Belongs to the JHDM3 histone demethylase family &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 2 PHD-type zinc fingers &  Contains 2 Tudor domains

uniprot_information:
SwissProt: Q9H3R0 # The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity)# Belongs to the JHDM3 histone demethylase family &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 2 PHD-type zinc fingers &  Contains 2 Tudor domains


uniprot_information_type:
SwissProt: Q99962 # An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface# Belongs to the endophilin family &  Contains 1 BAR domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q99962 # An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface# Belongs to the endophilin family &  Contains 1 BAR domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: Q5VZ89
uniprot_information:
Contains 1 dDENN domain &  Contains 1 DENN domain &  Contains 1 PPR (pentatricopeptide) repeat &  Contains 1 uDENN domain


uniprot_information_type:
SwissProt: Q12986 # The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination# Belongs to the NFX1 family &  Contains 8 NF-X1-type zinc fingers &  Contains 1 R3H domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q12986 # The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination# Belongs to the NFX1 family &  Contains 8 NF-X1-type zinc fingers &  Contains 1 R3H domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: A6NMY6 # A pair of annexin repeats may form one binding site for calcium and phospholipid (By similarity)# Belongs to the annexin family &  Contains 4 annexin repeats

uniprot_information:
SwissProt: A6NMY6 # A pair of annexin repeats may form one binding site for calcium and phospholipid (By similarity)# Belongs to the annexin family &  Contains 4 annexin repeats


uniprot_information_type: SwissProt: Q14626
uniprot_information:
Belongs to the type I cytokine receptor family. Type 3 subfamily &  Contains 2 fibronectin type-III domains &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: O14795 # The C2 domains are not involved in calcium-dependent phospholipid binding (By similarity)# Belongs to the unc-13 family &  Contains 3 C2 domains &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 MHD2 (MUNC13 homology domain 2) domain &  Contains 1 phorbol-ester/DAG-type zinc finger

uniprot_information:
SwissProt: O14795 # The C2 domains are not involved in calcium-dependent phospholipid binding (By similarity)# Belongs to the unc-13 family &  Contains 3 C2 domains &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 MHD2 (MUNC13 homology domain 2) domain &  Contains 1 phorbol-ester/DAG-type zinc finger


uniprot_information_type:
SwissProt: Q8N2Y8 # The RUN domain is required for the interaction with RAB1A and RAB1B# Contains 1 RUN domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q8N2Y8 # The RUN domain is required for the interaction with RAB1A and RAB1B# Contains 1 RUN domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q15569 # The extracatalytic C-terminal part is highly rich in proline residues# Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q15569 # The extracatalytic C-terminal part is highly rich in proline residues# Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q14680
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily &  Contains 1 KA1 (kinase-associated) domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9UDY2
uniprot_information:
Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 3 PDZ (DHR) domains &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q8IY18 # The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC6, forming a V-shaped heterodimer (By similarity)# Belongs to the SMC family. SMC5 subfamily

uniprot_information:
SwissProt: Q8IY18 # The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC6, forming a V-shaped heterodimer (By similarity)# Belongs to the SMC family. SMC5 subfamily


uniprot_information_type:
SwissProt: P04083 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats

uniprot_information:
SwissProt: P04083 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats


uniprot_information_type:
SwissProt: Q92882 # The SH3 domain mediates interaction with SMN1# Contains 3 ANK repeats &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q92882 # The SH3 domain mediates interaction with SMN1# Contains 3 ANK repeats &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q92824 # The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum# Belongs to the peptidase S8 family &  Contains 1 homo B/P domain &  Contains 1 PLAC domain

uniprot_information:
SwissProt: Q92824 # The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum# Belongs to the peptidase S8 family &  Contains 1 homo B/P domain &  Contains 1 PLAC domain


uniprot_information_type: SwissProt: Q16620
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 2 LRR (leucine-rich) repeats &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: P53355
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily &  Contains 10 ANK repeats &  Contains 1 death domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: P43405
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily &  Contains 1 protein kinase domain &  Contains 2 SH2 domains


uniprot_information_type: SwissProt: O75151
uniprot_information:
Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily &  Contains 1 JmjC domain &  Contains 1 PHD-type zinc finger


uniprot_information_type:
SwissProt: Q8IXK2 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q8IXK2 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: Q9Y283 # The D-box 1 (destruction box 1) mediates the interaction with APC2, and may act as a recognition signal for degradation via the ubiquitin-proteasome pathway (By similarity)# Contains 16 ANK repeats &  Contains 2 IQ domains

uniprot_information:
SwissProt: Q9Y283 # The D-box 1 (destruction box 1) mediates the interaction with APC2, and may act as a recognition signal for degradation via the ubiquitin-proteasome pathway (By similarity)# Contains 16 ANK repeats &  Contains 2 IQ domains


uniprot_information_type: SwissProt: O75820
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 16 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: O95347 # The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer (By similarity)# Belongs to the SMC family. SMC2 subfamily

uniprot_information:
SwissProt: O95347 # The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer (By similarity)# Belongs to the SMC family. SMC2 subfamily


uniprot_information_type:
SwissProt: Q9NVV0 # The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore (By similarity)# Belongs to the TMEM38 family

uniprot_information:
SwissProt: Q9NVV0 # The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore (By similarity)# Belongs to the TMEM38 family


uniprot_information_type:
SwissProt: P54727 # The ubiquitin-like domain mediates interaction with MJD# Belongs to the RAD23 family &  Contains 1 STI1 domain &  Contains 2 UBA domains &  Contains 1 ubiquitin-like domain

uniprot_information:
SwissProt: P54727 # The ubiquitin-like domain mediates interaction with MJD# Belongs to the RAD23 family &  Contains 1 STI1 domain &  Contains 2 UBA domains &  Contains 1 ubiquitin-like domain


uniprot_information_type:
SwissProt: Q9Y2D5 # The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer#

uniprot_information:
SwissProt: Q9Y2D5 # The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer#


uniprot_information_type: SwissProt: O15146
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family &  Contains 1 FZ (frizzled) domain &  Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q13049
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 5 NHL repeats &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: O00206 # The TIR domain mediates interaction with NOX4# Belongs to the Toll-like receptor family &  Contains 21 LRR (leucine-rich) repeats &  Contains 1 TIR domain

uniprot_information:
SwissProt: O00206 # The TIR domain mediates interaction with NOX4# Belongs to the Toll-like receptor family &  Contains 21 LRR (leucine-rich) repeats &  Contains 1 TIR domain


uniprot_information_type: SwissProt: Q7Z7M1
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 1 GPS domain &  Contains 1 pentaxin domain


uniprot_information_type: SwissProt: O43298
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 3 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q5JS13 # The PH domain mediates binding to membranes (Probable). The PH domain is also required for guanine nucleotide exchange of RALA# Contains 1 PH domain &  Contains 1 Ras-GEF domain

uniprot_information:
SwissProt: Q5JS13 # The PH domain mediates binding to membranes (Probable). The PH domain is also required for guanine nucleotide exchange of RALA# Contains 1 PH domain &  Contains 1 Ras-GEF domain


uniprot_information_type: SwissProt: Q13813
uniprot_information:
Belongs to the spectrin family &  Contains 3 EF-hand domains &  Contains 1 SH3 domain &  Contains 23 spectrin repeats


uniprot_information_type:
SwissProt: Q01105 # The C-terminal acidic domain mediates the inhibition of histone acetyltransferases and is required for the DNA replication stimulatory activity# Belongs to the nucleosome assembly protein (NAP) family

uniprot_information:
SwissProt: Q01105 # The C-terminal acidic domain mediates the inhibition of histone acetyltransferases and is required for the DNA replication stimulatory activity# Belongs to the nucleosome assembly protein (NAP) family


uniprot_information_type:
SwissProt: Q9Y2K6 # The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue (By similarity)# Belongs to the peptidase C19 family. USP20/USP33 subfamily &  Contains 2 DUSP domains &  Contains 1 UBP-type zinc finger

uniprot_information:
SwissProt: Q9Y2K6 # The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 55 is replaced by a Glu residue (By similarity)# Belongs to the peptidase C19 family. USP20/USP33 subfamily &  Contains 2 DUSP domains &  Contains 1 UBP-type zinc finger


uniprot_information_type:
SwissProt: Q9Y6N6 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domain IV is globular# Contains 11 laminin EGF-like domains &  Contains 1 laminin IV type A domain &  Contains 1 laminin N-terminal domain

uniprot_information:
SwissProt: Q9Y6N6 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domain IV is globular# Contains 11 laminin EGF-like domains &  Contains 1 laminin IV type A domain &  Contains 1 laminin N-terminal domain


uniprot_information_type:
SwissProt: Q5VTD9 # The zinc finger domains are essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain (By similarity)# Contains 6 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q5VTD9 # The zinc finger domains are essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain (By similarity)# Contains 6 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q76LX8 # The pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency &  The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction# Contains 2 CUB domains &  Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 8 TSP type-1 domains

uniprot_information:
SwissProt: Q76LX8 # The pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency &  The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction# Contains 2 CUB domains &  Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 8 TSP type-1 domains


uniprot_information_type:
SwissProt: P19793 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR2 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P19793 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR2 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type: SwissProt: P20908
uniprot_information:
Belongs to the fibrillar collagen family &  Contains 1 fibrillar collagen NC1 domain &  Contains 1 laminin G-like domain &  Contains 1 TSP N-terminal (TSPN) domain


uniprot_information_type:
SwissProt: Q15485 # The fibrinogen-like domain (FBG) contains potential calcium-binding sites that may be involved in carbohydrate binding# Belongs to the ficolin lectin family &  Contains 1 collagen-like domain &  Contains 1 fibrinogen C-terminal domain

uniprot_information:
SwissProt: Q15485 # The fibrinogen-like domain (FBG) contains potential calcium-binding sites that may be involved in carbohydrate binding# Belongs to the ficolin lectin family &  Contains 1 collagen-like domain &  Contains 1 fibrinogen C-terminal domain


uniprot_information_type:
SwissProt: Q12933 # The coiled coil domain mediates homo- and hetero-oligomerization &  The MATH/TRAF domain binds to receptor cytoplasmic domains# Belongs to the TNF receptor-associated factor family. A subfamily &  Contains 1 MATH domain &  Contains 1 RING-type zinc finger &  Contains 2 TRAF-type zinc fingers

uniprot_information:
SwissProt: Q12933 # The coiled coil domain mediates homo- and hetero-oligomerization &  The MATH/TRAF domain binds to receptor cytoplasmic domains# Belongs to the TNF receptor-associated factor family. A subfamily &  Contains 1 MATH domain &  Contains 1 RING-type zinc finger &  Contains 2 TRAF-type zinc fingers


uniprot_information_type:
SwissProt: P68371 # The highly acidic C-terminal region may bind cations such as calcium# Belongs to the tubulin family

uniprot_information:
SwissProt: P68371 # The highly acidic C-terminal region may bind cations such as calcium# Belongs to the tubulin family


uniprot_information_type:
SwissProt: Q9H9B1 # The SET domain mediates interaction with WIZ# Belongs to the histone-lysine methyltransferase family &  Contains 8 ANK repeats &  Contains 1 pre-SET domain &  Contains 1 SET domain

uniprot_information:
SwissProt: Q9H9B1 # The SET domain mediates interaction with WIZ# Belongs to the histone-lysine methyltransferase family &  Contains 8 ANK repeats &  Contains 1 pre-SET domain &  Contains 1 SET domain


uniprot_information_type:
SwissProt: Q00975 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily &  Contains 1 EF-hand domain

uniprot_information:
SwissProt: Q00975 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily &  Contains 1 EF-hand domain


uniprot_information_type:
SwissProt: Q9HC73 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is important for association with JAKs# Belongs to the type I cytokine receptor family. Type 5 subfamily &  Contains 1 fibronectin type-III domain

uniprot_information:
SwissProt: Q9HC73 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is important for association with JAKs# Belongs to the type I cytokine receptor family. Type 5 subfamily &  Contains 1 fibronectin type-III domain


uniprot_information_type: SwissProt: O15344
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 B30.2/SPRY domain &  Contains 1 COS domain &  Contains 1 fibronectin type-III domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q96DX5 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q96DX5 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: P51843 # Homodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with NR5A1/SF-1 and NROB2 through its N-terminal LXXLL motifs# Belongs to the nuclear hormone receptor family. NR0 subfamily

uniprot_information:
SwissProt: P51843 # Homodimerization involved an interaction between amino and carboxy termini involving LXXLL motifs and steroid binding domain (AF-2 motif). Heterodimerizes with NR5A1/SF-1 and NROB2 through its N-terminal LXXLL motifs# Belongs to the nuclear hormone receptor family. NR0 subfamily


uniprot_information_type: SwissProt: P11532
uniprot_information:
Contains 2 CH (calponin-homology) domains &  Contains 22 spectrin repeats &  Contains 1 WW domain &  Contains 1 ZZ-type zinc finger


uniprot_information_type:
SwissProt: O14936 # The first L27 domain binds DLG1 and the second L27 domain probably binds LIN7 (By similarity) &  The protein kinase domain mediates the interaction with FCHSD2# In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 2 L27 domains &  Contains 1 PDZ (DHR) domain &  Contains 1 protein kinase domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: O14936 # The first L27 domain binds DLG1 and the second L27 domain probably binds LIN7 (By similarity) &  The protein kinase domain mediates the interaction with FCHSD2# In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 2 L27 domains &  Contains 1 PDZ (DHR) domain &  Contains 1 protein kinase domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: P51814
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 18 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q9UHG2 # ProSAAS(1-180) increases secretion of enzymatically inactive PCSK1 (By similarity) &  The C-terminal inhibitory domain is involved in inhibtion of PCSK1. It corresponds to the probable processing intermediate Big PEN-LEN, binds to PCSK1 in vitro and contains the hexapeptide L-L-R-V-K-R, which, as a synthetic peptide, is sufficient for PCSK1 inhibition (By similarity)#

uniprot_information:
SwissProt: Q9UHG2 # ProSAAS(1-180) increases secretion of enzymatically inactive PCSK1 (By similarity) &  The C-terminal inhibitory domain is involved in inhibtion of PCSK1. It corresponds to the probable processing intermediate Big PEN-LEN, binds to PCSK1 in vitro and contains the hexapeptide L-L-R-V-K-R, which, as a synthetic peptide, is sufficient for PCSK1 inhibition (By similarity)#


uniprot_information_type:
SwissProt: Q9NSA2 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily

uniprot_information:
SwissProt: Q9NSA2 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily


uniprot_information_type: SwissProt: O43900
uniprot_information:
Belongs to the prickle / espinas / testin family &  Contains 3 LIM zinc-binding domains &  Contains 1 PET domain


uniprot_information_type:
SwissProt: P08247 # The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein# Belongs to the synaptophysin/synaptobrevin family &  Contains 1 MARVEL domain

uniprot_information:
SwissProt: P08247 # The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein# Belongs to the synaptophysin/synaptobrevin family &  Contains 1 MARVEL domain


uniprot_information_type:
SwissProt: O60840 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1F subfamily

uniprot_information:
SwissProt: O60840 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1F subfamily


uniprot_information_type:
SwissProt: Q5JQC9 # RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer (By similarity)# Belongs to the AKAP110 family

uniprot_information:
SwissProt: Q5JQC9 # RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer (By similarity)# Belongs to the AKAP110 family


uniprot_information_type:
SwissProt: P41229 # The first PHD-type zinc finger domain recognizes and binds H3-K9Me3 &  Both the JmjC domain and the JmjN domain are required for enzymatic activity# Belongs to the JARID1 histone demethylase family &  Contains 1 ARID domain &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 2 PHD-type zinc fingers

uniprot_information:
SwissProt: P41229 # The first PHD-type zinc finger domain recognizes and binds H3-K9Me3 &  Both the JmjC domain and the JmjN domain are required for enzymatic activity# Belongs to the JARID1 histone demethylase family &  Contains 1 ARID domain &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 2 PHD-type zinc fingers


uniprot_information_type:
SwissProt: Q14683 # The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity)# Belongs to the SMC family. SMC1 subfamily

uniprot_information:
SwissProt: Q14683 # The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity)# Belongs to the SMC family. SMC1 subfamily


uniprot_information_type:
SwissProt: Q7Z6Z7 # The HECT domain mediates inhibition of the transcriptional activity of p53# Belongs to the TOM1/PTR1 family &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 1 UBA domain &  Contains 1 UIM (ubiquitin-interacting motif) repeat &  Contains 1 WWE domain

uniprot_information:
SwissProt: Q7Z6Z7 # The HECT domain mediates inhibition of the transcriptional activity of p53# Belongs to the TOM1/PTR1 family &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 1 UBA domain &  Contains 1 UIM (ubiquitin-interacting motif) repeat &  Contains 1 WWE domain


uniprot_information_type:
SwissProt: Q9UPP1 # The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 promotes its access to H3K9me2 &  The linker region is a critical determinant of demethylase specificity. It enables the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3# Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily &  Contains 1 JmjC domain &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: Q9UPP1 # The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 promotes its access to H3K9me2 &  The linker region is a critical determinant of demethylase specificity. It enables the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3# Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily &  Contains 1 JmjC domain &  Contains 1 PHD-type zinc finger


uniprot_information_type:
SwissProt: P98174 # The DH domain is involved in interaction with CCPG1 (By similarity)# Contains 1 DH (DBL-homology) domain &  Contains 1 FYVE-type zinc finger &  Contains 2 PH domains

uniprot_information:
SwissProt: P98174 # The DH domain is involved in interaction with CCPG1 (By similarity)# Contains 1 DH (DBL-homology) domain &  Contains 1 FYVE-type zinc finger &  Contains 2 PH domains


uniprot_information_type:
SwissProt: Q8NG27 # The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination (By similarity)# Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8NG27 # The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination (By similarity)# Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: P31785 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 5 subfamily &  Contains 1 fibronectin type-III domain

uniprot_information:
SwissProt: P31785 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 5 subfamily &  Contains 1 fibronectin type-III domain


uniprot_information_type: SwissProt: Q2NKX8
uniprot_information:
Belongs to the SNF2/RAD54 helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 2 TPR repeats


uniprot_information_type:
SwissProt: P46100 # Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Belongs to the SNF2/RAD54 helicase family &  Contains 1 GATA-type zinc finger &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: P46100 # Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Belongs to the SNF2/RAD54 helicase family &  Contains 1 GATA-type zinc finger &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 PHD-type zinc finger


uniprot_information_type:
SwissProt: P82970 # Specifically targeted by its C-terminus to nucleosomes in euchromatin (By similarity)# Belongs to the HMGN family

uniprot_information:
SwissProt: P82970 # Specifically targeted by its C-terminus to nucleosomes in euchromatin (By similarity)# Belongs to the HMGN family


uniprot_information_type:
SwissProt: O60220 # The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8A from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity)# Belongs to the small Tim family

uniprot_information:
SwissProt: O60220 # The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8A from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity)# Belongs to the small Tim family


uniprot_information_type:
SwissProt: Q9H4D5 # Lacks C-terminal domain that mediates direct interactions with nucleoporins &  Contains a novel CRM1-dependent nuclear export signal that compensates in cis for the loss of the nuclear pore targeting domain# Belongs to the NXF family &  Contains 1 LRR (leucine-rich) repeat &  Contains 1 NTF2 domain &  Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q9H4D5 # Lacks C-terminal domain that mediates direct interactions with nucleoporins &  Contains a novel CRM1-dependent nuclear export signal that compensates in cis for the loss of the nuclear pore targeting domain# Belongs to the NXF family &  Contains 1 LRR (leucine-rich) repeat &  Contains 1 NTF2 domain &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: Q8WXH6 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the small GTPase superfamily. Rab family &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q8WXH6 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the small GTPase superfamily. Rab family &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: Q99576 # The leucine-zipper is involved in homodimerization (By similarity)# Belongs to the TSC-22/Dip/Bun family

uniprot_information:
SwissProt: Q99576 # The leucine-zipper is involved in homodimerization (By similarity)# Belongs to the TSC-22/Dip/Bun family


uniprot_information_type:
SwissProt: Q14031 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain

uniprot_information:
SwissProt: Q14031 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain


uniprot_information_type:
SwissProt: P51841 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the adenylyl cyclase class-4/guanylyl cyclase family &  Contains 1 guanylate cyclase domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P51841 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the adenylyl cyclase class-4/guanylyl cyclase family &  Contains 1 guanylate cyclase domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9UL62
uniprot_information:
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily &  Contains 2 ANK repeats


uniprot_information_type:
SwissProt: Q4VCS5 # The coiled coil domain interacts directly with the BAR domain of ARHGAP17 &  The angiostatin binding domain (871-1005) allows the binding to angiostatin# Belongs to the angiomotin family

uniprot_information:
SwissProt: Q4VCS5 # The coiled coil domain interacts directly with the BAR domain of ARHGAP17 &  The angiostatin binding domain (871-1005) allows the binding to angiostatin# Belongs to the angiomotin family


uniprot_information_type:
SwissProt: Q14627 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 5 subfamily &  Contains 1 fibronectin type-III domain

uniprot_information:
SwissProt: Q14627 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 5 subfamily &  Contains 1 fibronectin type-III domain


uniprot_information_type:
SwissProt: Q9UKZ4 # EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds &  Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins# Belongs to the tenascin family. Teneurin subfamily &  Contains 8 EGF-like domains &  Contains 5 NHL repeats &  Contains 1 teneurin N-terminal domain &  Contains 23 YD repeats

uniprot_information:
SwissProt: Q9UKZ4 # EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds &  Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins# Belongs to the tenascin family. Teneurin subfamily &  Contains 8 EGF-like domains &  Contains 5 NHL repeats &  Contains 1 teneurin N-terminal domain &  Contains 23 YD repeats


uniprot_information_type: SwissProt: P51815
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: Q15052
uniprot_information:
Contains 1 CH (calponin-homology) domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P10911 # The CRAL-TRIO domain is involved in interaction with inositol phospholipids &  The DH domain is essential for transforming activity and directly catalyzes GDP-GTP exchange activity. It may interact with CCPG1# Belongs to the MCF2 family &  Contains 1 CRAL-TRIO domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 spectrin repeat

uniprot_information:
SwissProt: P10911 # The CRAL-TRIO domain is involved in interaction with inositol phospholipids &  The DH domain is essential for transforming activity and directly catalyzes GDP-GTP exchange activity. It may interact with CCPG1# Belongs to the MCF2 family &  Contains 1 CRAL-TRIO domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 spectrin repeat


uniprot_information_type: SwissProt: P78334
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRE sub-subfamily


uniprot_information_type: SwissProt: P34903
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily


uniprot_information_type:
SwissProt: P51610 # The HCF repeat is a highly specific proteolytic cleavage signal &  The kelch repeats fold into a 6-bladed kelch beta-propeller called the beta-propeller domain which mediates interaction with HCFC1R1# Contains 5 Kelch repeats

uniprot_information:
SwissProt: P51610 # The HCF repeat is a highly specific proteolytic cleavage signal &  The kelch repeats fold into a 6-bladed kelch beta-propeller called the beta-propeller domain which mediates interaction with HCFC1R1# Contains 5 Kelch repeats


uniprot_information_type: SwissProt: P51617
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P21333 # Comprised of a NH2-terminal actin-binding domain, 24 internally homologous repeats and two hinge regions. Repeat 24 and the second hinge domain are important for dimer formation# Belongs to the filamin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 24 filamin repeats

uniprot_information:
SwissProt: P21333 # Comprised of a NH2-terminal actin-binding domain, 24 internally homologous repeats and two hinge regions. Repeat 24 and the second hinge domain are important for dimer formation# Belongs to the filamin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 24 filamin repeats


uniprot_information_type: SwissProt: Q00013
uniprot_information:
Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 1 PDZ (DHR) domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P00451 # Domain F5/8 type C 2 is responsible for phospholipid-binding and essential for factor VIII activity# Belongs to the multicopper oxidase family &  Contains 3 F5/8 type A domains &  Contains 2 F5/8 type C domains &  Contains 6 plastocyanin-like domains

uniprot_information:
SwissProt: P00451 # Domain F5/8 type C 2 is responsible for phospholipid-binding and essential for factor VIII activity# Belongs to the multicopper oxidase family &  Contains 3 F5/8 type A domains &  Contains 2 F5/8 type C domains &  Contains 6 plastocyanin-like domains


uniprot_information_type:
SwissProt: O15247 # Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion# Belongs to the chloride channel CLIC family &  Contains 1 GST C-terminal domain

uniprot_information:
SwissProt: O15247 # Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion# Belongs to the chloride channel CLIC family &  Contains 1 GST C-terminal domain


uniprot_information_type:
SwissProt: P15509 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 5 subfamily

uniprot_information:
SwissProt: P15509 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 5 subfamily


uniprot_information_type:
SwissProt: P26951 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 5 subfamily

uniprot_information:
SwissProt: P26951 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 5 subfamily


uniprot_information_type:
SwissProt: O60907 # The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes (By similarity)# Belongs to the WD repeat EBI family &  Contains 1 F-box-like domain &  Contains 1 LisH domain &  Contains 8 WD repeats

uniprot_information:
SwissProt: O60907 # The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes (By similarity)# Belongs to the WD repeat EBI family &  Contains 1 F-box-like domain &  Contains 1 LisH domain &  Contains 8 WD repeats


uniprot_information_type:
SwissProt: Q13796 # The ASD1 domain mediates F-actin binding (By similarity)# Belongs to the shroom family &  Contains 1 ASD1 domain &  Contains 1 ASD2 domain &  Contains 1 PDZ (DHR) domain

uniprot_information:
SwissProt: Q13796 # The ASD1 domain mediates F-actin binding (By similarity)# Belongs to the shroom family &  Contains 1 ASD1 domain &  Contains 1 ASD2 domain &  Contains 1 PDZ (DHR) domain


uniprot_information_type: SwissProt: P53701
uniprot_information:
Belongs to the cytochrome c-type heme lyase family &  Contains 2 HRM (heme regulatory motif) repeats


uniprot_information_type:
SwissProt: Q14CM0 # The FERM domain mediates the interaction with phosphatidylinositol-4,5-bisphosphate# Contains 1 FERM domain &  Contains 1 PDZ (DHR) domain &  Contains 1 WW domain

uniprot_information:
SwissProt: Q14CM0 # The FERM domain mediates the interaction with phosphatidylinositol-4,5-bisphosphate# Contains 1 FERM domain &  Contains 1 PDZ (DHR) domain &  Contains 1 WW domain


uniprot_information_type: SwissProt: Q9NYK1
uniprot_information:
Belongs to the Toll-like receptor family &  Contains 27 LRR (leucine-rich) repeats &  Contains 1 TIR domain


uniprot_information_type: SwissProt: Q9NR97
uniprot_information:
Belongs to the Toll-like receptor family &  Contains 24 LRR (leucine-rich) repeats &  Contains 1 TIR domain


uniprot_information_type: SwissProt: P23416
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA2 sub-subfamily


uniprot_information_type:
SwissProt: P51813 # SH2 domain mediates interaction with RUFY1# Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily &  Contains 1 Btk-type zinc finger &  Contains 1 PH domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain

uniprot_information:
SwissProt: P51813 # SH2 domain mediates interaction with RUFY1# Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily &  Contains 1 Btk-type zinc finger &  Contains 1 PH domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain


uniprot_information_type: SwissProt: Q8WXI2
uniprot_information:
Belongs to the CNKSR family &  Contains 1 CRIC domain &  Contains 1 DUF1170 domain &  Contains 1 PDZ (DHR) domain &  Contains 1 PH domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: P52788 # Composed of 3 domains: the N-terminal domain has structural similarity to S-adenosylmethionine decarboxylase, the central domain is made up of four beta strands and the C-terminal domain is similar in structure to spermidine synthase. The N- and C-terminal domains are both required for activity# Belongs to the spermidine/spermine synthase family

uniprot_information:
SwissProt: P52788 # Composed of 3 domains: the N-terminal domain has structural similarity to S-adenosylmethionine decarboxylase, the central domain is made up of four beta strands and the C-terminal domain is similar in structure to spermidine synthase. The N- and C-terminal domains are both required for activity# Belongs to the spermidine/spermine synthase family


uniprot_information_type: SwissProt: P17010
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily &  Contains 13 C2H2-type zinc fingers


uniprot_information_type: SwissProt: O00571
uniprot_information:
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: Q9GZU5
uniprot_information:
Belongs to the small leucine-rich proteoglycan (SLRP) family. Class IV subfamily &  Contains 11 LRR (leucine-rich) repeats


uniprot_information_type: SwissProt: P98175
uniprot_information:
Contains 1 C2H2-type zinc finger &  Contains 1 G-patch domain &  Contains 1 RanBP2-type zinc finger &  Contains 2 RRM (RNA recognition motif) domains


uniprot_information_type:
SwissProt: P42768 # The WH1 (Wasp homology 1) domain may bind a Pro-rich ligand &  The CRIB (Cdc42/Rac-interactive-binding) region binds to the C-terminal WH2 domain in the autoinhibited state of the protein. Binding of Rho-type GTPases to the CRIB induces a conformation change and leads to activation# Contains 1 CRIB domain &  Contains 1 WH1 domain &  Contains 1 WH2 domain

uniprot_information:
SwissProt: P42768 # The WH1 (Wasp homology 1) domain may bind a Pro-rich ligand &  The CRIB (Cdc42/Rac-interactive-binding) region binds to the C-terminal WH2 domain in the autoinhibited state of the protein. Binding of Rho-type GTPases to the CRIB induces a conformation change and leads to activation# Contains 1 CRIB domain &  Contains 1 WH1 domain &  Contains 1 WH2 domain


uniprot_information_type:
SwissProt: O43463 # Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin# Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily &  Contains 1 chromo domain &  Contains 1 post-SET domain &  Contains 1 pre-SET domain &  Contains 1 SET domain

uniprot_information:
SwissProt: O43463 # Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin# Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily &  Contains 1 chromo domain &  Contains 1 post-SET domain &  Contains 1 pre-SET domain &  Contains 1 SET domain


uniprot_information_type:
SwissProt: P15976 # The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding (By similarity)# Contains 2 GATA-type zinc fingers

uniprot_information:
SwissProt: P15976 # The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding (By similarity)# Contains 2 GATA-type zinc fingers


uniprot_information_type:
SwissProt: O60828 # The WW domain may play a role as a transcriptional activator directly or via association with the transcription machinery. The WW domain mediates interaction with C-terminal domain of RNA polymerase II large subunit# Contains 1 WW domain

uniprot_information:
SwissProt: O60828 # The WW domain may play a role as a transcriptional activator directly or via association with the transcription machinery. The WW domain mediates interaction with C-terminal domain of RNA polymerase II large subunit# Contains 1 WW domain


uniprot_information_type:
SwissProt: Q9NVN8 # In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern# Belongs to the MMR1/HSR1 GTP-binding protein family

uniprot_information:
SwissProt: Q9NVN8 # In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern# Belongs to the MMR1/HSR1 GTP-binding protein family


uniprot_information_type:
SwissProt: P10275 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA. The transcription factor activity of the complex formed by ligand-activated AR and DNA is modulated by interactions with coactivator and corepressor proteins. Interaction with RANBP9 is mediated by both the N-terminal domain and the DNA-binding domain. Interaction with EFCAB6/DJBP is mediated by the DNA-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P10275 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA. The transcription factor activity of the complex formed by ligand-activated AR and DNA is modulated by interactions with coactivator and corepressor proteins. Interaction with RANBP9 is mediated by both the N-terminal domain and the DNA-binding domain. Interaction with EFCAB6/DJBP is mediated by the DNA-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type: SwissProt: O95239
uniprot_information:
Belongs to the kinesin-like protein family. Chromokinesin subfamily &  Contains 1 kinesin-motor domain


uniprot_information_type:
SwissProt: Q9UKP3 # The tail domain binds to the cytoplasmic domain of both integrin beta-1a and beta-1d isoforms. The presence of Ca(2+) ions does not prevent binding of a fragment consisting of the second cysteine rich repeat and the tail domain but prevents the binding of the full-length protein# Contains 2 CHORD domains &  Contains 1 CS domain

uniprot_information:
SwissProt: Q9UKP3 # The tail domain binds to the cytoplasmic domain of both integrin beta-1a and beta-1d isoforms. The presence of Ca(2+) ions does not prevent binding of a fragment consisting of the second cysteine rich repeat and the tail domain but prevents the binding of the full-length protein# Contains 2 CHORD domains &  Contains 1 CS domain


uniprot_information_type: SwissProt: P21675
uniprot_information:
Belongs to the TAF1 family &  Contains 2 bromo domains &  Contains 1 HMG box DNA-binding domain &  Contains 2 protein kinase domains


uniprot_information_type:
SwissProt: Q9Y237 # The PPIase domain enhances mitochondrial targeting# Belongs to the ppiC/parvulin rotamase family. PIN4 subfamily &  Contains 1 PpiC domain

uniprot_information:
SwissProt: Q9Y237 # The PPIase domain enhances mitochondrial targeting# Belongs to the ppiC/parvulin rotamase family. PIN4 subfamily &  Contains 1 PpiC domain


uniprot_information_type:
SwissProt: Q04656 # The C-terminal di-leucine, 1487-Leu-Leu-1488, is an endocytic targeting signal which functions in retrieving recycling from the plasma membrane to the TGN. Mutation of the di-leucine signal results in the accumulation of the protein in the plasma membrane# Belongs to the cation transport ATPase (P-type) family. Type IB subfamily &  Contains 6 HMA domains

uniprot_information:
SwissProt: Q04656 # The C-terminal di-leucine, 1487-Leu-Leu-1488, is an endocytic targeting signal which functions in retrieving recycling from the plasma membrane to the TGN. Mutation of the di-leucine signal results in the accumulation of the protein in the plasma membrane# Belongs to the cation transport ATPase (P-type) family. Type IB subfamily &  Contains 6 HMA domains


uniprot_information_type:
SwissProt: O60879 # DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction (By similarity)# Belongs to the formin homology family. Diaphanous subfamily &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain

uniprot_information:
SwissProt: O60879 # DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction (By similarity)# Belongs to the formin homology family. Diaphanous subfamily &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


uniprot_information_type:
SwissProt: Q00994 # The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR (By similarity)# Belongs to the BEX family

uniprot_information:
SwissProt: Q00994 # The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR (By similarity)# Belongs to the BEX family


uniprot_information_type:
SwissProt: Q8TEB7 # Binding to E2 ubiquitin-conjugating enzyme requires an intact RING finger domain# Contains 1 PA (protease associated) domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8TEB7 # Binding to E2 ubiquitin-conjugating enzyme requires an intact RING finger domain# Contains 1 PA (protease associated) domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9UJV3 # The tripartite motif (RBCC; RING- and B box-type zinc fingers and coiled coil domains) mediates dimerization (By similarity) &  Associates with microtubules in a manner that is dependent on the C-terminal B30.2 domain# Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 B30.2/SPRY domain &  Contains 1 COS domain &  Contains 1 fibronectin type-III domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q9UJV3 # The tripartite motif (RBCC; RING- and B box-type zinc fingers and coiled coil domains) mediates dimerization (By similarity) &  Associates with microtubules in a manner that is dependent on the C-terminal B30.2 domain# Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 B30.2/SPRY domain &  Contains 1 COS domain &  Contains 1 fibronectin type-III domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: P29400 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain

uniprot_information:
SwissProt: P29400 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain


uniprot_information_type:
SwissProt: P28335 # The PDZ domain-binding motif is involved in the interaction with MPDZ# Belongs to the G-protein coupled receptor 1 family

uniprot_information:
SwissProt: P28335 # The PDZ domain-binding motif is involved in the interaction with MPDZ# Belongs to the G-protein coupled receptor 1 family


uniprot_information_type:
SwissProt: P78552 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 5 subfamily

uniprot_information:
SwissProt: P78552 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 5 subfamily


uniprot_information_type:
SwissProt: O00264 # The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131 (By similarity)# Belongs to the cytochrome b5 family. MAPR subfamily &  Contains 1 cytochrome b5 heme-binding domain

uniprot_information:
SwissProt: O00264 # The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131 (By similarity)# Belongs to the cytochrome b5 family. MAPR subfamily &  Contains 1 cytochrome b5 heme-binding domain


uniprot_information_type:
SwissProt: Q9ULC4 # The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly trough interaction with other proteins# Belongs to the MCTS1 family &  Contains 1 PUA domain

uniprot_information:
SwissProt: Q9ULC4 # The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly trough interaction with other proteins# Belongs to the MCTS1 family &  Contains 1 PUA domain


uniprot_information_type:
SwissProt: P98170 # The first BIR domain is involved in interaction with TAB1/MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit caspase-3 and caspase-7, while the third BIR is involved in caspase-9 inhibition. The interactions with SMAC and PRSS25 are mediated by the second and third BIR domains# Belongs to the IAP family &  Contains 3 BIR repeats &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: P98170 # The first BIR domain is involved in interaction with TAB1/MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit caspase-3 and caspase-7, while the third BIR is involved in caspase-9 inhibition. The interactions with SMAC and PRSS25 are mediated by the second and third BIR domains# Belongs to the IAP family &  Contains 3 BIR repeats &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: O43719 # The RRM domains mediate interaction with U snRNPs# Contains 2 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: O43719 # The RRM domains mediate interaction with U snRNPs# Contains 2 RRM (RNA recognition motif) domains


uniprot_information_type:
SwissProt: P00740 # Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain# Belongs to the peptidase S1 family &  Contains 2 EGF-like domains &  Contains 1 Gla (gamma-carboxy-glutamate) domain &  Contains 1 peptidase S1 domain

uniprot_information:
SwissProt: P00740 # Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain# Belongs to the peptidase S1 family &  Contains 2 EGF-like domains &  Contains 1 Gla (gamma-carboxy-glutamate) domain &  Contains 1 peptidase S1 domain


uniprot_information_type: SwissProt: Q13496
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily &  Contains 1 GRAM domain &  Contains 1 myotubularin phosphatase domain


uniprot_information_type: SwissProt: Q9UN88
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub-subfamily


uniprot_information_type: SwissProt: P21810
uniprot_information:
Belongs to the small leucine-rich proteoglycan (SLRP) family. Class I subfamily &  Contains 12 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q16635 # The hydrophilic domain may serve as an exposed loop interacting with other proteins# Belongs to the taffazin family

uniprot_information:
SwissProt: Q16635 # The hydrophilic domain may serve as an exposed loop interacting with other proteins# Belongs to the taffazin family


uniprot_information_type:
SwissProt: Q9Y6K9 # The leucine-zipper domain and the C2HC-type zinc-finger are essential for polyubiquitin binding and for the activation of IRF3# Contains 1 C2HC-type zinc finger

uniprot_information:
SwissProt: Q9Y6K9 # The leucine-zipper domain and the C2HC-type zinc-finger are essential for polyubiquitin binding and for the activation of IRF3# Contains 1 C2HC-type zinc finger


uniprot_information_type:
SwissProt: Q01113 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 4 subfamily &  Contains 1 fibronectin type-III domain

uniprot_information:
SwissProt: Q01113 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 4 subfamily &  Contains 1 fibronectin type-III domain


uniprot_information_type:
SwissProt: Q9BY66 # The JmjC domain is required for enzymatic activity# Belongs to the JARID1 histone demethylase family &  Contains 1 ARID domain &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 2 PHD-type zinc fingers

uniprot_information:
SwissProt: Q9BY66 # The JmjC domain is required for enzymatic activity# Belongs to the JARID1 histone demethylase family &  Contains 1 ARID domain &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 2 PHD-type zinc fingers


uniprot_information_type:
SwissProt: Q9BQ87 # The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes (By similarity)# Belongs to the WD repeat EBI family &  Contains 1 F-box-like domain &  Contains 1 LisH domain &  Contains 8 WD repeats

uniprot_information:
SwissProt: Q9BQ87 # The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes (By similarity)# Belongs to the WD repeat EBI family &  Contains 1 F-box-like domain &  Contains 1 LisH domain &  Contains 8 WD repeats


uniprot_information_type: SwissProt: O43930
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. cAMP subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q99612 # The acidic N-terminal part may favor interaction with the basic domain of transcription factors# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 3 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q99612 # The acidic N-terminal part may favor interaction with the basic domain of transcription factors# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 3 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q8WXK3 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q8WXK3 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: Q04759 # The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q04759 # The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O60870 # The C-terminal domain (268-393) is organized into 2 subdomains that bear structural similarities to SH3-like domains. Both subdomains adopt a similar 5-stranded beta-barrel-like fold and are connected to each other by a short linker of 5 residues. The 5 beta-sheets are packed at approximately right angles against each other. A highly conserved groove formed at the interface between the 2 subdomains, comprised of Lys residues 302 and 391 and other positively charged residues, may possibly be the site of RNA-binding# Belongs to the KIN17 family &  Contains 1 C2H2-type zinc finger

uniprot_information:
SwissProt: O60870 # The C-terminal domain (268-393) is organized into 2 subdomains that bear structural similarities to SH3-like domains. Both subdomains adopt a similar 5-stranded beta-barrel-like fold and are connected to each other by a short linker of 5 residues. The 5 beta-sheets are packed at approximately right angles against each other. A highly conserved groove formed at the interface between the 2 subdomains, comprised of Lys residues 302 and 391 and other positively charged residues, may possibly be the site of RNA-binding# Belongs to the KIN17 family &  Contains 1 C2H2-type zinc finger


uniprot_information_type:
SwissProt: O60494 # The CUB domains 5 to 8 mediate binding to GIF and ALB. CUB domains 1 and 2 mediate interaction with LRP2# Contains 27 CUB domains &  Contains 7 EGF-like domains

uniprot_information:
SwissProt: O60494 # The CUB domains 5 to 8 mediate binding to GIF and ALB. CUB domains 1 and 2 mediate interaction with LRP2# Contains 27 CUB domains &  Contains 7 EGF-like domains


uniprot_information_type:
SwissProt: Q8IZP0 # The t-SNARE coiled-coil homology domain is necessary and sufficient for interaction with STX1A (By similarity)# Belongs to the ABI family &  Contains 1 SH3 domain &  Contains 1 t-SNARE coiled-coil homology domain

uniprot_information:
SwissProt: Q8IZP0 # The t-SNARE coiled-coil homology domain is necessary and sufficient for interaction with STX1A (By similarity)# Belongs to the ABI family &  Contains 1 SH3 domain &  Contains 1 t-SNARE coiled-coil homology domain


uniprot_information_type: SwissProt: Q96TA2
uniprot_information:
In the N-terminal section; belongs to the AAA ATPase family &  In the C-terminal section; belongs to the peptidase M41 family


uniprot_information_type: SwissProt: O95425
uniprot_information:
Belongs to the villin/gelsolin family &  Contains 5 gelsolin-like repeats &  Contains 1 HP (headpiece) domain


uniprot_information_type:
SwissProt: P33176 # Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles# Belongs to the kinesin-like protein family. Kinesin subfamily &  Contains 1 kinesin-motor domain

uniprot_information:
SwissProt: P33176 # Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles# Belongs to the kinesin-like protein family. Kinesin subfamily &  Contains 1 kinesin-motor domain


uniprot_information_type:
SwissProt: Q8TEW0 # Contains a conserved N-terminal oligomerization domain (NTD) that is involved in oligomerization and is essential for proper subapical membrane localization (By similarity) &  The second PDZ domain mediates interaction with membranes containing phosphoinositol lipids (By similarity)# Belongs to the PAR3 family &  Contains 3 PDZ (DHR) domains

uniprot_information:
SwissProt: Q8TEW0 # Contains a conserved N-terminal oligomerization domain (NTD) that is involved in oligomerization and is essential for proper subapical membrane localization (By similarity) &  The second PDZ domain mediates interaction with membranes containing phosphoinositol lipids (By similarity)# Belongs to the PAR3 family &  Contains 3 PDZ (DHR) domains


uniprot_information_type:
SwissProt: P52597 # The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA# Contains 3 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: P52597 # The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA# Contains 3 RRM (RNA recognition motif) domains


uniprot_information_type:
SwissProt: Q5T0T0 # The RING-CH-type zinc finger domain is required for E3 ligase activity# Contains 1 RING-CH-type zinc finger

uniprot_information:
SwissProt: Q5T0T0 # The RING-CH-type zinc finger domain is required for E3 ligase activity# Contains 1 RING-CH-type zinc finger


uniprot_information_type:
SwissProt: Q03468 # A C-terminal ubiquitin-binding domain (UBD) is essential for transcription-coupled nucleotide excision repair to proceed# Belongs to the SNF2/RAD54 helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain

uniprot_information:
SwissProt: Q03468 # A C-terminal ubiquitin-binding domain (UBD) is essential for transcription-coupled nucleotide excision repair to proceed# Belongs to the SNF2/RAD54 helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q9NQ94 # The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity# Contains 3 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: Q9NQ94 # The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity# Contains 3 RRM (RNA recognition motif) domains


uniprot_information_type:
SwissProt: Q16204 # The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation#

uniprot_information:
SwissProt: Q16204 # The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation#


uniprot_information_type:
SwissProt: Q15652 # Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity)# Belongs to the JHDM2 histone demethylase family &  Contains 1 JmjC domain

uniprot_information:
SwissProt: Q15652 # Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity)# Belongs to the JHDM2 histone demethylase family &  Contains 1 JmjC domain


uniprot_information_type: SwissProt: P14222
uniprot_information:
Belongs to the complement C6/C7/C8/C9 family &  Contains 1 C2 domain &  Contains 1 EGF-like domain &  Contains 1 MACPF domain


uniprot_information_type:
SwissProt: P20073 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats

uniprot_information:
SwissProt: P20073 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats


uniprot_information_type: SwissProt: Q8TDM6
uniprot_information:
Belongs to the MAGUK family &  Contains 1 CARD domain &  Contains 1 guanylate kinase-like domain &  Contains 4 PDZ (DHR) domains &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P50995 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats

uniprot_information:
SwissProt: P50995 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats


uniprot_information_type: SwissProt: Q9P2V4
uniprot_information:
Contains 1 fibronectin type-III domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 6 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q9UQK1 # The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase (By similarity)# Contains 1 CBM21 (carbohydrate binding type-21) domain

uniprot_information:
SwissProt: Q9UQK1 # The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase (By similarity)# Contains 1 CBM21 (carbohydrate binding type-21) domain


uniprot_information_type:
SwissProt: Q9NZM1 # The C2 domain 1 associates with lipid membranes in a calcium-dependent manner# Belongs to the ferlin family &  Contains 5 C2 domains

uniprot_information:
SwissProt: Q9NZM1 # The C2 domain 1 associates with lipid membranes in a calcium-dependent manner# Belongs to the ferlin family &  Contains 5 C2 domains


uniprot_information_type: SwissProt: P54886
uniprot_information:
In the N-terminal section; belongs to the glutamate 5-kinase family &  In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family


uniprot_information_type:
SwissProt: Q9Y3B2 # The N- and C-terminal regions of the protein are required for interaction with RRP46# Contains 1 S1 motif domain

uniprot_information:
SwissProt: Q9Y3B2 # The N- and C-terminal regions of the protein are required for interaction with RRP46# Contains 1 S1 motif domain


uniprot_information_type:
SwissProt: Q5T4F7 # The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the secreted frizzled-related protein (sFRP) family &  Contains 1 FZ (frizzled) domain &  Contains 1 NTR domain

uniprot_information:
SwissProt: Q5T4F7 # The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the secreted frizzled-related protein (sFRP) family &  Contains 1 FZ (frizzled) domain &  Contains 1 NTR domain


uniprot_information_type:
SwissProt: Q86U70 # The dimerization domain is located in the N-terminus (By similarity)# Belongs to the LDB family

uniprot_information:
SwissProt: Q86U70 # The dimerization domain is located in the N-terminus (By similarity)# Belongs to the LDB family


uniprot_information_type:
SwissProt: Q9H467 # The CUE domain mediates interaction with PGR and ESR1# Belongs to the CUEDC2 family &  Contains 1 CUE domain

uniprot_information:
SwissProt: Q9H467 # The CUE domain mediates interaction with PGR and ESR1# Belongs to the CUEDC2 family &  Contains 1 CUE domain


uniprot_information_type:
SwissProt: Q5TCZ1 # The PX domain is required for podosome localization, and for binding phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2) &  The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19# Belongs to the SH3PXD2 family &  Contains 1 PX (phox homology) domain &  Contains 5 SH3 domains

uniprot_information:
SwissProt: Q5TCZ1 # The PX domain is required for podosome localization, and for binding phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2) &  The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19# Belongs to the SH3PXD2 family &  Contains 1 PX (phox homology) domain &  Contains 5 SH3 domains


uniprot_information_type:
SwissProt: Q9H6R6 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q9H6R6 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: Q9H5V7 # The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members &  C-terminal zinc fingers mediate homodimerization# Belongs to the Ikaros C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q9H5V7 # The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members &  C-terminal zinc fingers mediate homodimerization# Belongs to the Ikaros C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: O43184 # The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: O43184 # The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain


uniprot_information_type: SwissProt: Q15326
uniprot_information:
Contains 1 bromo domain &  Contains 1 MYND-type zinc finger &  Contains 1 PHD-type zinc finger &  Contains 1 PWWP domain


uniprot_information_type:
SwissProt: Q8IU85 # The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q8IU85 # The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q7L590 # The zinc finger-like domain binds a zinc ion and is involved in self-association (By similarity)# Belongs to the MCM10 family

uniprot_information:
SwissProt: Q7L590 # The zinc finger-like domain binds a zinc ion and is involved in self-association (By similarity)# Belongs to the MCM10 family


uniprot_information_type:
SwissProt: Q9H5I1 # Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin (By similarity)# Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily &  Contains 1 chromo domain &  Contains 1 post-SET domain &  Contains 1 pre-SET domain &  Contains 1 SET domain

uniprot_information:
SwissProt: Q9H5I1 # Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin (By similarity)# Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily &  Contains 1 chromo domain &  Contains 1 post-SET domain &  Contains 1 pre-SET domain &  Contains 1 SET domain


uniprot_information_type: SwissProt: P22897
uniprot_information:
Contains 8 C-type lectin domains &  Contains 1 fibronectin type-II domain &  Contains 1 ricin B-type lectin domain


uniprot_information_type: SwissProt: Q8NEV4
uniprot_information:
In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family &  Contains 3 IQ domains &  Contains 1 myosin head-like domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q7Z5R6 # The two Pro-rich regions are required for the suppression of AP1 transcription activity# Belongs to the MRL family &  Contains 1 PH domain &  Contains 1 Ras-associating domain

uniprot_information:
SwissProt: Q7Z5R6 # The two Pro-rich regions are required for the suppression of AP1 transcription activity# Belongs to the MRL family &  Contains 1 PH domain &  Contains 1 Ras-associating domain


uniprot_information_type: SwissProt: P07949
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family &  Contains 1 cadherin domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P45983 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P45983 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q13976 # Heterotetramerization is mediated by the interaction between a coiled-coil of PRKG1 and the leucine/isoleucine zipper of PPP1R12A/MBS, the myosin-binding subunit of the myosin phosphatase# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 2 cyclic nucleotide-binding domains &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q13976 # Heterotetramerization is mediated by the interaction between a coiled-coil of PRKG1 and the leucine/isoleucine zipper of PPP1R12A/MBS, the myosin-binding subunit of the myosin phosphatase# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 2 cyclic nucleotide-binding domains &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O94907 # The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)# Belongs to the dickkopf family

uniprot_information:
SwissProt: O94907 # The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)# Belongs to the dickkopf family


uniprot_information_type: SwissProt: Q9BQ39
uniprot_information:
Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q9NR30 # The two enzymatic activities reside in two separate domains, the helicase in the N-terminus and the foldase in the C-terminus &  The 3 X 5 AA repeats seem to be critical for the RNA folding activity (By similarity)# Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain

uniprot_information:
SwissProt: Q9NR30 # The two enzymatic activities reside in two separate domains, the helicase in the N-terminus and the foldase in the C-terminus &  The 3 X 5 AA repeats seem to be critical for the RNA folding activity (By similarity)# Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: P19367 # The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose and Gluc-6-P molecule# Belongs to the hexokinase family

uniprot_information:
SwissProt: P19367 # The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose and Gluc-6-P molecule# Belongs to the hexokinase family


uniprot_information_type: SwissProt: P00749
uniprot_information:
Belongs to the peptidase S1 family &  Contains 1 EGF-like domain &  Contains 1 kringle domain &  Contains 1 peptidase S1 domain


uniprot_information_type:
SwissProt: Q8WYB5 # The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression# Belongs to the MYST (SAS/MOZ) family &  Contains 1 C2HC-type zinc finger &  Contains 2 PHD-type zinc fingers

uniprot_information:
SwissProt: Q8WYB5 # The N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression# Belongs to the MYST (SAS/MOZ) family &  Contains 1 C2HC-type zinc finger &  Contains 2 PHD-type zinc fingers


uniprot_information_type:
SwissProt: P45880 # Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands (By similarity)# Belongs to the eukaryotic mitochondrial porin family

uniprot_information:
SwissProt: P45880 # Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands (By similarity)# Belongs to the eukaryotic mitochondrial porin family


uniprot_information_type:
SwissProt: Q9ULJ6 # The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein# Contains 1 SP-RING-type zinc finger

uniprot_information:
SwissProt: Q9ULJ6 # The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein# Contains 1 SP-RING-type zinc finger


uniprot_information_type:
SwissProt: P60484 # The C2 domain binds phospholipid membranes in vitro in a Ca(2+)-independent manner; this binding is important for its tumor suppressor function# Contains 1 C2 tensin-type domain &  Contains 1 phosphatase tensin-type domain

uniprot_information:
SwissProt: P60484 # The C2 domain binds phospholipid membranes in vitro in a Ca(2+)-independent manner; this binding is important for its tumor suppressor function# Contains 1 C2 tensin-type domain &  Contains 1 phosphatase tensin-type domain


uniprot_information_type:
SwissProt: P25445 # Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins# Contains 1 death domain &  Contains 3 TNFR-Cys repeats

uniprot_information:
SwissProt: P25445 # Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins# Contains 1 death domain &  Contains 3 TNFR-Cys repeats


uniprot_information_type: SwissProt: O14981
uniprot_information:
Belongs to the SNF2/RAD54 helicase family &  Contains 8 HEAT repeats &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q9NX47 # The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-CH-type zinc finger

uniprot_information:
SwissProt: Q9NX47 # The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-CH-type zinc finger


uniprot_information_type:
SwissProt: Q9P212 # The Ras-associating domain 1 is degenerated and may not bind HRAS. The Ras-associating domain 2 mediates interaction with GTP-bound HRAS, RAP1A, RAP2A and RAP2B and recruitment of HRAS to the cell membrane &  The Ras-GEF domain has a GEF activity towards HRAS and RAP1A. Mediates activation of the mitogen-activated protein kinase pathway# Contains 1 C2 domain &  Contains 1 PI-PLC X-box domain &  Contains 1 PI-PLC Y-box domain &  Contains 2 Ras-associating domains &  Contains 1 Ras-GEF domain

uniprot_information:
SwissProt: Q9P212 # The Ras-associating domain 1 is degenerated and may not bind HRAS. The Ras-associating domain 2 mediates interaction with GTP-bound HRAS, RAP1A, RAP2A and RAP2B and recruitment of HRAS to the cell membrane &  The Ras-GEF domain has a GEF activity towards HRAS and RAP1A. Mediates activation of the mitogen-activated protein kinase pathway# Contains 1 C2 domain &  Contains 1 PI-PLC X-box domain &  Contains 1 PI-PLC Y-box domain &  Contains 2 Ras-associating domains &  Contains 1 Ras-GEF domain


uniprot_information_type:
SwissProt: O00767 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the fatty acid desaturase family

uniprot_information:
SwissProt: O00767 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the fatty acid desaturase family


uniprot_information_type:
SwissProt: Q00653 # The C-terminus of p100 might be involved in cytoplasmic retention, inhibition of DNA-binding by p52 homodimers, and/or transcription activation (By similarity) &  The glycine-rich region (GRR) appears to be a critical element in the generation of p52# Contains 7 ANK repeats &  Contains 1 death domain &  Contains 1 RHD (Rel-like) domain

uniprot_information:
SwissProt: Q00653 # The C-terminus of p100 might be involved in cytoplasmic retention, inhibition of DNA-binding by p52 homodimers, and/or transcription activation (By similarity) &  The glycine-rich region (GRR) appears to be a critical element in the generation of p52# Contains 7 ANK repeats &  Contains 1 death domain &  Contains 1 RHD (Rel-like) domain


uniprot_information_type:
SwissProt: Q9BZR9 # The coiled coil domain is required for homodimerization &  The region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1 (By similarity)# Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q9BZR9 # The coiled coil domain is required for homodimerization &  The region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1 (By similarity)# Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q15542 # Distinct domains of TAF5/TAFII100 are required for functional interaction with transcription factor TFIIFB (RAP30) and incorporation into the TFIID complex# Belongs to the WD repeat TAF5 family &  Contains 1 LisH domain &  Contains 6 WD repeats

uniprot_information:
SwissProt: Q15542 # Distinct domains of TAF5/TAFII100 are required for functional interaction with transcription factor TFIIFB (RAP30) and incorporation into the TFIID complex# Belongs to the WD repeat TAF5 family &  Contains 1 LisH domain &  Contains 6 WD repeats


uniprot_information_type: SwissProt: Q9H2G2
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 protein kinase domain &  Contains 1 UVR domain


uniprot_information_type: SwissProt: P78417
uniprot_information:
Belongs to the GST superfamily. Omega family &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain


uniprot_information_type:
SwissProt: Q9UEY8 # Comprised of three regions: a N-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region# Belongs to the aldolase class II family. Adducin subfamily

uniprot_information:
SwissProt: Q9UEY8 # Comprised of three regions: a N-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region# Belongs to the aldolase class II family. Adducin subfamily


uniprot_information_type:
SwissProt: Q9UQE7 # The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC1A or SMC1B, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity)# Belongs to the SMC family. SMC3 subfamily

uniprot_information:
SwissProt: Q9UQE7 # The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC1A or SMC1B, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity)# Belongs to the SMC family. SMC3 subfamily


uniprot_information_type:
SwissProt: Q53EL6 # Binds EIF4A1 via the MA3 domains (By similarity)# Belongs to the PDCD4 family &  Contains 2 MI domains

uniprot_information:
SwissProt: Q53EL6 # Binds EIF4A1 via the MA3 domains (By similarity)# Belongs to the PDCD4 family &  Contains 2 MI domains


uniprot_information_type:
SwissProt: Q9NQB0 # The promoter-specific activation domain interacts with the transcriptional coactivator EP300# Belongs to the TCF/LEF family &  Contains 1 HMG box DNA-binding domain

uniprot_information:
SwissProt: Q9NQB0 # The promoter-specific activation domain interacts with the transcriptional coactivator EP300# Belongs to the TCF/LEF family &  Contains 1 HMG box DNA-binding domain


uniprot_information_type: SwissProt: Q14520
uniprot_information:
Belongs to the peptidase S1 family &  Contains 3 EGF-like domains &  Contains 1 kringle domain &  Contains 1 peptidase S1 domain


uniprot_information_type:
SwissProt: P08588 # The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor# Belongs to the G-protein coupled receptor 1 family. Adrenoceptor subfamily. ADRB1 sub-subfamily

uniprot_information:
SwissProt: P08588 # The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor# Belongs to the G-protein coupled receptor 1 family. Adrenoceptor subfamily. ADRB1 sub-subfamily


uniprot_information_type: SwissProt: Q5VV63
uniprot_information:
Contains 1 C-type lectin domain &  Contains 1 CUB domain &  Contains 2 EGF-like domains &  Contains 6 Kelch repeats &  Contains 2 laminin EGF-like domains &  Contains 5 PSI domains


uniprot_information_type: SwissProt: Q9Y6Y8
uniprot_information:
Belongs to the PA-PLA1 family &  Contains 1 DDHD domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: Q9HB21 # Binds to membranes enriched in PtdIns3,4P2 via the C-terminal PH domain# Contains 2 PH domains

uniprot_information:
SwissProt: Q9HB21 # Binds to membranes enriched in PtdIns3,4P2 via the C-terminal PH domain# Contains 2 PH domains


uniprot_information_type: SwissProt: Q92743
uniprot_information:
Belongs to the peptidase S1B family &  Contains 1 IGFBP N-terminal domain &  Contains 1 Kazal-like domain &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: Q9UGM3 # The SRCR domains mediate binding to bacteria. The minimal bacterial-binding site is an 11-residue repeat of GRVEVLYRGSW where VEVL and W are critical residues# Belongs to the DMBT1 family &  Contains 2 CUB domains &  Contains 14 SRCR domains &  Contains 1 ZP domain

uniprot_information:
SwissProt: Q9UGM3 # The SRCR domains mediate binding to bacteria. The minimal bacterial-binding site is an 11-residue repeat of GRVEVLYRGSW where VEVL and W are critical residues# Belongs to the DMBT1 family &  Contains 2 CUB domains &  Contains 14 SRCR domains &  Contains 1 ZP domain


uniprot_information_type:
SwissProt: Q15018 # The MPN-like region is similar to the MPN (JAB/Mov34) domain# Belongs to the FAM175 family. Abro1 subfamily

uniprot_information:
SwissProt: Q15018 # The MPN-like region is similar to the MPN (JAB/Mov34) domain# Belongs to the FAM175 family. Abro1 subfamily


uniprot_information_type:
SwissProt: Q14185 # The DHR-2 domain is necessary and sufficient for the GEF activity# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q14185 # The DHR-2 domain is necessary and sufficient for the GEF activity# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P23469 # The tyrosine-protein phosphatase 2 domain (D2) mediates dimerization. The extreme N- and C- termini of the D2 domain act to inhibit dimerization and removal of these sequences increases dimerization and inhibits enzyme activity (By similarity)# Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily &  Contains 2 tyrosine-protein phosphatase domains

uniprot_information:
SwissProt: P23469 # The tyrosine-protein phosphatase 2 domain (D2) mediates dimerization. The extreme N- and C- termini of the D2 domain act to inhibit dimerization and removal of these sequences increases dimerization and inhibits enzyme activity (By similarity)# Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily &  Contains 2 tyrosine-protein phosphatase domains


uniprot_information_type:
SwissProt: O76003 # The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks thioredoxin activity# Contains 2 glutaredoxin domains &  Contains 1 thioredoxin domain

uniprot_information:
SwissProt: O76003 # The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks thioredoxin activity# Contains 2 glutaredoxin domains &  Contains 1 thioredoxin domain


uniprot_information_type:
SwissProt: Q5T230 # The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity)#

uniprot_information:
SwissProt: Q5T230 # The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity)#


uniprot_information_type:
SwissProt: O43812 # Homebox domain 2 confers nuclear targeting# Belongs to the paired homeobox family &  Contains 2 homeobox DNA-binding domains

uniprot_information:
SwissProt: O43812 # Homebox domain 2 confers nuclear targeting# Belongs to the paired homeobox family &  Contains 2 homeobox DNA-binding domains


uniprot_information_type: SwissProt: Q6IA17
uniprot_information:
Belongs to the interleukin-1 receptor family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 TIR domain


uniprot_information_type: SwissProt: Q9HB75
uniprot_information:
Contains 1 death domain &  Contains 7 LRR (leucine-rich) repeats &  Contains 1 peptidase S68 domain &  Contains 2 ZU5 domains


uniprot_information_type: SwissProt: Q6W4X9
uniprot_information:
Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 1 TIL (trypsin inhibitory-like) domain &  Contains 3 VWFD domains


uniprot_information_type:
SwissProt: Q53GA4 # The PH domain binds phosphoinositides with a broad specificity. It may compete with the PH domain of some other proteins, thereby interfering with their binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3) (By similarity)# Belongs to the PHLDA2 family &  Contains 1 PH domain

uniprot_information:
SwissProt: Q53GA4 # The PH domain binds phosphoinositides with a broad specificity. It may compete with the PH domain of some other proteins, thereby interfering with their binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3) (By similarity)# Belongs to the PHLDA2 family &  Contains 1 PH domain


uniprot_information_type: SwissProt: Q9GZZ6
uniprot_information:
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily


uniprot_information_type:
SwissProt: P52948 # Contains G-L-F-G repeats# Belongs to the nucleoporin GLFG family &  Contains 1 peptidase S59 domain

uniprot_information:
SwissProt: P52948 # Contains G-L-F-G repeats# Belongs to the nucleoporin GLFG family &  Contains 1 peptidase S59 domain


uniprot_information_type:
SwissProt: P19474 # The coiled-coil is necessary for the cytoplasmic localization. The B30.2/SPRY domain is necessary for the cytoplasmic localization, the interaction with IRF3 and for the IRF3-driven interferon beta promoter activity. The RING-type zinc finger is necessary for ubiquitination and for the IRF3-driven interferon beta promoter activity. Interacts with SKP2 and CUL1 in a RING finger-independent manner# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: P19474 # The coiled-coil is necessary for the cytoplasmic localization. The B30.2/SPRY domain is necessary for the cytoplasmic localization, the interaction with IRF3 and for the IRF3-driven interferon beta promoter activity. The RING-type zinc finger is necessary for ubiquitination and for the IRF3-driven interferon beta promoter activity. Interacts with SKP2 and CUL1 in a RING finger-independent manner# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q6AZZ1 # The RING domain is essential for ubiquitin E3 ligase activity# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q6AZZ1 # The RING domain is essential for ubiquitin E3 ligase activity# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9C035 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q9C035 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: O75382 # The interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades (By similarity)# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 filamin repeat &  Contains 6 NHL repeats &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: O75382 # The interaction with MYO5B is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades (By similarity)# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 filamin repeat &  Contains 6 NHL repeats &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q12962 # The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase# Belongs to the TAF10 family

uniprot_information:
SwissProt: Q12962 # The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase# Belongs to the TAF10 family


uniprot_information_type: SwissProt: Q6IQ26
uniprot_information:
Belongs to the RAB6IP1 family &  Contains 1 dDENN domain &  Contains 1 DENN domain &  Contains 1 PLAT domain &  Contains 2 RUN domains &  Contains 1 uDENN domain


uniprot_information_type:
SwissProt: Q9UBP4 # The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)# Belongs to the dickkopf family

uniprot_information:
SwissProt: Q9UBP4 # The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)# Belongs to the dickkopf family


uniprot_information_type:
SwissProt: Q9Y6N9 # The PDZ domain 1 mediates interactions with USH1G/SANS and SLC4A7# Contains 3 PDZ (DHR) domains

uniprot_information:
SwissProt: Q9Y6N9 # The PDZ domain 1 mediates interactions with USH1G/SANS and SLC4A7# Contains 3 PDZ (DHR) domains


uniprot_information_type:
SwissProt: Q99816 # The UEV domain is required for the interaction of the complex with ubiquitin. It also mediates the interaction with PTAP/PSAP motifs of HIV-1 P6 protein and human spumaretrovirus Gag protein &  The coiled coil domain may interact with stathmin &  The UEV domain binds ubiquitin and P-[ST]-A-P peptide motif independently# Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily &  Contains 1 SB (steadiness box) domain &  Contains 1 UEV (ubiquitin E2 variant) domain

uniprot_information:
SwissProt: Q99816 # The UEV domain is required for the interaction of the complex with ubiquitin. It also mediates the interaction with PTAP/PSAP motifs of HIV-1 P6 protein and human spumaretrovirus Gag protein &  The coiled coil domain may interact with stathmin &  The UEV domain binds ubiquitin and P-[ST]-A-P peptide motif independently# Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily &  Contains 1 SB (steadiness box) domain &  Contains 1 UEV (ubiquitin E2 variant) domain


uniprot_information_type: SwissProt: Q8IX04
uniprot_information:
In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily &  In the C-terminal section; belongs to the LDH/MDH superfamily &  Contains 1 UEV (ubiquitin E2 variant) domain


uniprot_information_type:
SwissProt: A0AVK6 # Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity)# Belongs to the E2F/DP family

uniprot_information:
SwissProt: A0AVK6 # Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer (By similarity)# Belongs to the E2F/DP family


uniprot_information_type:
SwissProt: Q9NUP9 # The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane (By similarity) &  The PDZ domain regulates endocytosis and recycling of the receptor at the membrane (By similarity) &  The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes (By similarity)# Belongs to the lin-7 family &  Contains 1 L27 domain &  Contains 1 PDZ (DHR) domain

uniprot_information:
SwissProt: Q9NUP9 # The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane (By similarity) &  The PDZ domain regulates endocytosis and recycling of the receptor at the membrane (By similarity) &  The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes (By similarity)# Belongs to the lin-7 family &  Contains 1 L27 domain &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: P22459 # The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments &  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily

uniprot_information:
SwissProt: P22459 # The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments &  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily


uniprot_information_type:
SwissProt: P25791 # The second LIM zinc-binding domain interacts with KDM5A# Contains 2 LIM zinc-binding domains

uniprot_information:
SwissProt: P25791 # The second LIM zinc-binding domain interacts with KDM5A# Contains 2 LIM zinc-binding domains


uniprot_information_type:
SwissProt: Q9UKW6 # The PNT domain acts as a transcriptional activator (By similarity)# Belongs to the ETS family &  Contains 1 ETS DNA-binding domain &  Contains 1 PNT (pointed) domain

uniprot_information:
SwissProt: Q9UKW6 # The PNT domain acts as a transcriptional activator (By similarity)# Belongs to the ETS family &  Contains 1 ETS DNA-binding domain &  Contains 1 PNT (pointed) domain


uniprot_information_type: SwissProt: Q6UXH9
uniprot_information:
Belongs to the peptidase S1 family &  Contains 1 CUB domain &  Contains 1 EGF-like domain &  Contains 1 peptidase S1 domain &  Contains 2 Sushi (CCP/SCR) domains


uniprot_information_type:
SwissProt: Q9Y4K3 # The coiled coil domain mediates homo- and hetero-oligomerization &  The MATH/TRAF domain binds to receptor cytoplasmic domains# Belongs to the TNF receptor-associated factor family. A subfamily &  Contains 1 MATH domain &  Contains 1 RING-type zinc finger &  Contains 2 TRAF-type zinc fingers

uniprot_information:
SwissProt: Q9Y4K3 # The coiled coil domain mediates homo- and hetero-oligomerization &  The MATH/TRAF domain binds to receptor cytoplasmic domains# Belongs to the TNF receptor-associated factor family. A subfamily &  Contains 1 MATH domain &  Contains 1 RING-type zinc finger &  Contains 2 TRAF-type zinc fingers


uniprot_information_type:
SwissProt: P55895 # The atypical PHD-type zinc finger recognizes and binds histone H3 trimethylated on 'Lys-4' (H3K4me3). The presence Tyr-445 instead of a carboxylate in classical PHD-type zinc fingers results in an enhanced binding to H3K4me3 in presence of dimethylated on 'Arg-2' (H3R2me2) rather than inhibited. The atypical PHD-type zinc finger also binds various phosphoinositides, such as phosphatidylinositol-3,4-bisphosphate binding (PtdIns(3,4)P2), phosphatidylinositol-3,5-bisphosphate binding (PtdIns(3,5)P2), phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-trisphosphate binding (PtdIns(3,4,5)P3) (By similarity)# Belongs to the RAG2 family &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: P55895 # The atypical PHD-type zinc finger recognizes and binds histone H3 trimethylated on 'Lys-4' (H3K4me3). The presence Tyr-445 instead of a carboxylate in classical PHD-type zinc fingers results in an enhanced binding to H3K4me3 in presence of dimethylated on 'Arg-2' (H3R2me2) rather than inhibited. The atypical PHD-type zinc finger also binds various phosphoinositides, such as phosphatidylinositol-3,4-bisphosphate binding (PtdIns(3,4)P2), phosphatidylinositol-3,5-bisphosphate binding (PtdIns(3,5)P2), phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-trisphosphate binding (PtdIns(3,4,5)P3) (By similarity)# Belongs to the RAG2 family &  Contains 1 PHD-type zinc finger


uniprot_information_type:
SwissProt: Q7L8C5 # The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding (By similarity) &  The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present (By similarity)# Belongs to the synaptotagmin family &  Contains 2 C2 domains

uniprot_information:
SwissProt: Q7L8C5 # The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding (By similarity) &  The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present (By similarity)# Belongs to the synaptotagmin family &  Contains 2 C2 domains


uniprot_information_type: SwissProt: O75096
uniprot_information:
Belongs to the LDLR family &  Contains 3 EGF-like domains &  Contains 8 LDL-receptor class A domains &  Contains 20 LDL-receptor class B repeats


uniprot_information_type: SwissProt: Q14896
uniprot_information:
Belongs to the immunoglobulin superfamily. MyBP family &  Contains 3 fibronectin type-III domains &  Contains 7 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q13702 # A cysteine-rich region homologous to part of the regulatory domain of protein kinase C may be important in interactions of this protein with the lipid bilayer# Belongs to the RAPsyn family &  Contains 1 RING-type zinc finger &  Contains 7 TPR repeats

uniprot_information:
SwissProt: Q13702 # A cysteine-rich region homologous to part of the regulatory domain of protein kinase C may be important in interactions of this protein with the lipid bilayer# Belongs to the RAPsyn family &  Contains 1 RING-type zinc finger &  Contains 7 TPR repeats


uniprot_information_type: SwissProt: Q9NVX7
uniprot_information:
Contains 1 BACK (BTB/Kelch associated) domain &  Contains 1 BTB (POZ) domain &  Contains 5 Kelch repeats


uniprot_information_type:
SwissProt: Q8N3X1 # These WW domains interact with Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (WBPs). The N-terminal WW domain has the greater ligand-binding ability (By similarity)# Contains 2 WW domains

uniprot_information:
SwissProt: Q8N3X1 # These WW domains interact with Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (WBPs). The N-terminal WW domain has the greater ligand-binding ability (By similarity)# Contains 2 WW domains


uniprot_information_type:
SwissProt: Q04609 # The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal# Belongs to the peptidase M28 family. M28B subfamily

uniprot_information:
SwissProt: Q04609 # The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal# Belongs to the peptidase M28 family. M28B subfamily


uniprot_information_type:
SwissProt: Q08945 # The HMG box DNA-binding domain mediates DNA-binding. It has both affinity and specificity for DNA damaged globally with cisplatin# Belongs to the SSRP1 family &  Contains 1 HMG box DNA-binding domain

uniprot_information:
SwissProt: Q08945 # The HMG box DNA-binding domain mediates DNA-binding. It has both affinity and specificity for DNA damaged globally with cisplatin# Belongs to the SSRP1 family &  Contains 1 HMG box DNA-binding domain


uniprot_information_type:
SwissProt: P62072 # The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable)# Belongs to the small Tim family

uniprot_information:
SwissProt: P62072 # The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable)# Belongs to the small Tim family


uniprot_information_type:
SwissProt: P22059 # The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding (By similarity) &  The second coiled-coil domain is required for interaction with the tyrosine phosphatase (By similarity)# Belongs to the OSBP family &  Contains 1 PH domain

uniprot_information:
SwissProt: P22059 # The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding (By similarity) &  The second coiled-coil domain is required for interaction with the tyrosine phosphatase (By similarity)# Belongs to the OSBP family &  Contains 1 PH domain


uniprot_information_type:
SwissProt: O60427 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the fatty acid desaturase family &  Contains 1 cytochrome b5 heme-binding domain

uniprot_information:
SwissProt: O60427 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the fatty acid desaturase family &  Contains 1 cytochrome b5 heme-binding domain


uniprot_information_type:
SwissProt: Q9Y5Q0 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the fatty acid desaturase family &  Contains 1 cytochrome b5 heme-binding domain

uniprot_information:
SwissProt: Q9Y5Q0 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the fatty acid desaturase family &  Contains 1 cytochrome b5 heme-binding domain


uniprot_information_type: SwissProt: P26641
uniprot_information:
Contains 1 EF-1-gamma C-terminal domain &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain


uniprot_information_type: SwissProt: O94776
uniprot_information:
Contains 1 BAH domain &  Contains 1 ELM2 domain &  Contains 1 GATA-type zinc finger &  Contains 1 SANT domain


uniprot_information_type:
SwissProt: Q04323 # The UBA domain specifically recognizes and binds 'Lys-6'-linked polyubiquitin chains# Contains 1 UBA domain &  Contains 1 UBX domain

uniprot_information:
SwissProt: Q04323 # The UBA domain specifically recognizes and binds 'Lys-6'-linked polyubiquitin chains# Contains 1 UBA domain &  Contains 1 UBX domain


uniprot_information_type:
SwissProt: Q9UBU9 # The minimal CTE binding domain consists of an RNP-type RNA binding domain (RBD) and leucine-rich repeats &  The nucleoporin binding domain consists of a NTF2 domain (also called NTF2-like domain) and a TAP-C domain (also called UBA-like domain). It has 2 nucleoporin-FG-repeats binding sites (one in the NTF2 and the other in the TAP-C domain) which contribute to nucleoporin association and act synergistically to export cellular mRNAs &  The NTF2 domain is functional only in the presence of NXT1 and is essential for the export of mRNA from the nucleus &  The TAP-C domain mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF1 to the nuclear rim. The conserved loop 594-NWD-596 of the TAP-C domain has a critical role in the interaction with nucleoporins &  The leucine-rich repeats are essential for the export of mRNA from the nucleus# Belongs to the NXF family &  Contains 4 LRR (leucine-rich) repeats &  Contains 1 NTF2 domain &  Contains 1 RRM (RNA recognition motif) domain &  Contains 1 TAP-C domain

uniprot_information:
SwissProt: Q9UBU9 # The minimal CTE binding domain consists of an RNP-type RNA binding domain (RBD) and leucine-rich repeats &  The nucleoporin binding domain consists of a NTF2 domain (also called NTF2-like domain) and a TAP-C domain (also called UBA-like domain). It has 2 nucleoporin-FG-repeats binding sites (one in the NTF2 and the other in the TAP-C domain) which contribute to nucleoporin association and act synergistically to export cellular mRNAs &  The NTF2 domain is functional only in the presence of NXT1 and is essential for the export of mRNA from the nucleus &  The TAP-C domain mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF1 to the nuclear rim. The conserved loop 594-NWD-596 of the TAP-C domain has a critical role in the interaction with nucleoporins &  The leucine-rich repeats are essential for the export of mRNA from the nucleus# Belongs to the NXF family &  Contains 4 LRR (leucine-rich) repeats &  Contains 1 NTF2 domain &  Contains 1 RRM (RNA recognition motif) domain &  Contains 1 TAP-C domain


uniprot_information_type:
SwissProt: Q4U2R8 # Multiple cysteine residues are necessary for proper targeting to the plasma membrane (By similarity)# Belongs to the major facilitator superfamily. Organic cation transporter family

uniprot_information:
SwissProt: Q4U2R8 # Multiple cysteine residues are necessary for proper targeting to the plasma membrane (By similarity)# Belongs to the major facilitator superfamily. Organic cation transporter family


uniprot_information_type:
SwissProt: Q92934 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family# Belongs to the Bcl-2 family

uniprot_information:
SwissProt: Q92934 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family# Belongs to the Bcl-2 family


uniprot_information_type:
P58401 # Alternative splicing in the laminin G-like domain regulates binding to alpha-dystroglycan# Belongs to the neurexin family &  Contains 1 laminin G-like domain

uniprot_information:
P58401 # Alternative splicing in the laminin G-like domain regulates binding to alpha-dystroglycan# Belongs to the neurexin family &  Contains 1 laminin G-like domain


uniprot_information_type:
SwissProt: Q7LDG7 # The N-terminal Ras-GEF domain mediates association with F-actin# Belongs to the RASGRP family &  Contains 2 EF-hand domains &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 Ras-GEF domain

uniprot_information:
SwissProt: Q7LDG7 # The N-terminal Ras-GEF domain mediates association with F-actin# Belongs to the RASGRP family &  Contains 2 EF-hand domains &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 Ras-GEF domain


uniprot_information_type:
SwissProt: Q9H4M9 # The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity)# Contains 1 EF-hand domain &  Contains 1 EH domain

uniprot_information:
SwissProt: Q9H4M9 # The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity)# Contains 1 EF-hand domain &  Contains 1 EH domain


uniprot_information_type:
SwissProt: Q9NS15 # Associates covalently with small latent TGF-beta complex via Repeat C# Belongs to the LTBP family &  Contains 13 EGF-like domains &  Contains 4 TB (TGF-beta binding) domains

uniprot_information:
SwissProt: Q9NS15 # Associates covalently with small latent TGF-beta complex via Repeat C# Belongs to the LTBP family &  Contains 13 EGF-like domains &  Contains 4 TB (TGF-beta binding) domains


uniprot_information_type: SwissProt: Q16584
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily &  Contains 1 protein kinase domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: Q13671
uniprot_information:
Belongs to the RIN (Ras interaction/interference) family &  Contains 1 Ras-associating domain &  Contains 1 SH2 domain &  Contains 1 VPS9 domain


uniprot_information_type:
SwissProt: Q6UX98 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q6UX98 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type: SwissProt: P11498
uniprot_information:
Contains 1 ATP-grasp domain &  Contains 1 biotin carboxylation domain &  Contains 1 biotinyl-binding domain &  Contains 1 carboxyltransferase domain


uniprot_information_type: SwissProt: Q4FZB7
uniprot_information:
Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily &  Contains 1 SET domain


uniprot_information_type:
SwissProt: Q9UPX8 # The PDZ domain is required for interaction with GRID2, PLCB3, CFTR and SLC9A3 (By similarity)# Belongs to the SHANK family &  Contains 1 PDZ (DHR) domain &  Contains 1 SAM (sterile alpha motif) domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q9UPX8 # The PDZ domain is required for interaction with GRID2, PLCB3, CFTR and SLC9A3 (By similarity)# Belongs to the SHANK family &  Contains 1 PDZ (DHR) domain &  Contains 1 SAM (sterile alpha motif) domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: O00408 # GAF 1 functions as a dimerization domain, whereas GAF 2 binds cGMP, which causes activation of the catalytic activity of the enzyme (By similarity)# Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily &  Contains 2 GAF domains

uniprot_information:
SwissProt: O00408 # GAF 1 functions as a dimerization domain, whereas GAF 2 binds cGMP, which causes activation of the catalytic activity of the enzyme (By similarity)# Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily &  Contains 2 GAF domains


uniprot_information_type: SwissProt: Q96P48
uniprot_information:
Contains 1 Arf-GAP domain &  Contains 4 PH domains &  Contains 1 Ras-associating domain &  Contains 1 Rho-GAP domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: P49407 # The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1 (By similarity). Binding to phosphorylated GPCRs induces a conformationanl change that exposes the motif to the surface &  The N-terminus binds InsP6 with low affinity (By similarity) &  The C-terminus binds InsP6 with high affinity (By similarity)# Belongs to the arrestin family

uniprot_information:
SwissProt: P49407 # The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1 (By similarity). Binding to phosphorylated GPCRs induces a conformationanl change that exposes the motif to the surface &  The N-terminus binds InsP6 with low affinity (By similarity) &  The C-terminus binds InsP6 with high affinity (By similarity)# Belongs to the arrestin family


uniprot_information_type:
SwissProt: Q9UQC2 # The SH3-binding motifs mediate interaction with SHC1 and GRB2 (By similarity) &  The PH domain mediates phosphatidylinositol-3,4,5-trisphosphate and phosphatidylinositol-3,4-bisphosphate binding (By similarity)# Belongs to the GAB family &  Contains 1 PH domain

uniprot_information:
SwissProt: Q9UQC2 # The SH3-binding motifs mediate interaction with SHC1 and GRB2 (By similarity) &  The PH domain mediates phosphatidylinositol-3,4,5-trisphosphate and phosphatidylinositol-3,4-bisphosphate binding (By similarity)# Belongs to the GAB family &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q6N022 # EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds &  Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins# Belongs to the tenascin family. Teneurin subfamily &  Contains 8 EGF-like domains &  Contains 5 NHL repeats &  Contains 1 teneurin N-terminal domain &  Contains 23 YD repeats

uniprot_information:
SwissProt: Q6N022 # EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds &  Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins# Belongs to the tenascin family. Teneurin subfamily &  Contains 8 EGF-like domains &  Contains 5 NHL repeats &  Contains 1 teneurin N-terminal domain &  Contains 23 YD repeats


uniprot_information_type:
SwissProt: Q15700 # Isoform 2 has an L27 domain close to N-terminus# Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 3 PDZ (DHR) domains &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q15700 # Isoform 2 has an L27 domain close to N-terminus# Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 3 PDZ (DHR) domains &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q9HCH5 # The RabBD domain mediates interaction with RAB27A and recruitment on to vesicular structures in cytotoxic T-lymphocytes (CTL) &  The C2 1 domain mediates binding to phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and localization to the cell membrane# Contains 2 C2 domains &  Contains 1 RabBD (Rab-binding) domain

uniprot_information:
SwissProt: Q9HCH5 # The RabBD domain mediates interaction with RAB27A and recruitment on to vesicular structures in cytotoxic T-lymphocytes (CTL) &  The C2 1 domain mediates binding to phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and localization to the cell membrane# Contains 2 C2 domains &  Contains 1 RabBD (Rab-binding) domain


uniprot_information_type:
SwissProt: Q9ULV1 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain

uniprot_information:
SwissProt: Q9ULV1 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain


uniprot_information_type:
SwissProt: Q13614 # The coiled-coil domain mediates interaction with SBF2# Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily &  Contains 1 GRAM domain &  Contains 1 myotubularin phosphatase domain

uniprot_information:
SwissProt: Q13614 # The coiled-coil domain mediates interaction with SBF2# Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily &  Contains 1 GRAM domain &  Contains 1 myotubularin phosphatase domain


uniprot_information_type:
SwissProt: P06401 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P06401 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type: SwissProt: Q9Y210
uniprot_information:
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily &  Contains 4 ANK repeats


uniprot_information_type:
SwissProt: P09237 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family

uniprot_information:
SwissProt: P09237 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family


uniprot_information_type:
SwissProt: O60882 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: O60882 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: Q9H306 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: Q9H306 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: P22894 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: P22894 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: P09238 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: P09238 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: P03956 # There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases) &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: P03956 # There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases) &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: P08254 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: P08254 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: P39900 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: P39900 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: Q14207 # The LisH domain is required for the activation of histone gene transcription# Belongs to the NPAT family &  Contains 1 LisH domain

uniprot_information:
SwissProt: Q14207 # The LisH domain is required for the activation of histone gene transcription# Belongs to the NPAT family &  Contains 1 LisH domain


uniprot_information_type:
SwissProt: P35241 # The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ablilty to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN (By similarity)# Contains 1 FERM domain

uniprot_information:
SwissProt: P35241 # The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ablilty to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN (By similarity)# Contains 1 FERM domain


uniprot_information_type:
SwissProt: P30154 # Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure# Belongs to the phosphatase 2A regulatory subunit A family &  Contains 15 HEAT repeats

uniprot_information:
SwissProt: P30154 # Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure# Belongs to the phosphatase 2A regulatory subunit A family &  Contains 15 HEAT repeats


uniprot_information_type:
SwissProt: Q9Y5J9 # The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity)# Belongs to the small Tim family

uniprot_information:
SwissProt: Q9Y5J9 # The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity)# Belongs to the small Tim family


uniprot_information_type:
SwissProt: Q9BY67 # The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC# Belongs to the nectin family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q9BY67 # The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC# Belongs to the nectin family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: P06727 # Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities# Belongs to the apolipoprotein A1/A4/E family

uniprot_information:
SwissProt: P06727 # Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities# Belongs to the apolipoprotein A1/A4/E family


uniprot_information_type: SwissProt: Q9Y2K2
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily &  Contains 1 protein kinase domain &  Contains 1 UBA domain


uniprot_information_type:
SwissProt: P56817 # The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP# Belongs to the peptidase A1 family

uniprot_information:
SwissProt: P56817 # The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP# Belongs to the peptidase A1 family


uniprot_information_type: SwissProt: O60939
uniprot_information:
Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P26196
uniprot_information:
Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: P16104 # The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family# Belongs to the histone H2A family

uniprot_information:
SwissProt: P16104 # The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family# Belongs to the histone H2A family


uniprot_information_type: SwissProt: P43121
uniprot_information:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 2 Ig-like V-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: O75604 # The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity (By similarity)# Belongs to the peptidase C19 family. USP2 subfamily

uniprot_information:
SwissProt: O75604 # The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity (By similarity)# Belongs to the peptidase C19 family. USP2 subfamily


uniprot_information_type: SwissProt: Q9NY72
uniprot_information:
Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: Q8WZ75
uniprot_information:
Belongs to the immunoglobulin superfamily. ROBO family &  Contains 2 fibronectin type-III domains &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: A7KAX9 # The N-terminal PX domain interacts specifically with phosphatidylinositides (By similarity)# Belongs to the PX domain-containing GAP family &  Contains 1 PX (phox homology) domain &  Contains 1 Rho-GAP domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: A7KAX9 # The N-terminal PX domain interacts specifically with phosphatidylinositides (By similarity)# Belongs to the PX domain-containing GAP family &  Contains 1 PX (phox homology) domain &  Contains 1 Rho-GAP domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q9NQV6 # The SET domain is degenerated, suggesting that it has lost mehtyltransferase activity# Contains 10 C2H2-type zinc fingers &  Contains 1 SET domain

uniprot_information:
SwissProt: Q9NQV6 # The SET domain is degenerated, suggesting that it has lost mehtyltransferase activity# Contains 10 C2H2-type zinc fingers &  Contains 1 SET domain


uniprot_information_type:
SwissProt: Q9UP79 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 2 TSP type-1 domains

uniprot_information:
SwissProt: Q9UP79 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 2 TSP type-1 domains


uniprot_information_type: SwissProt: Q92543
uniprot_information:
Belongs to the sorting nexin family &  Contains 1 PX (phox homology) domain &  Contains 1 PXA domain


uniprot_information_type: SwissProt: Q9UPX0
uniprot_information:
Belongs to the immunoglobulin superfamily. Turtle family &  Contains 2 fibronectin type-III domains &  Contains 5 Ig-like (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q02817
uniprot_information:
Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 1 TIL (trypsin inhibitory-like) domain &  Contains 2 VWFC domains &  Contains 4 VWFD domains


uniprot_information_type:
SwissProt: Q9HC84 # The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding# Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 1 TIL (trypsin inhibitory-like) domain &  Contains 3 VWFC domains &  Contains 4 VWFD domains

uniprot_information:
SwissProt: Q9HC84 # The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding# Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 1 TIL (trypsin inhibitory-like) domain &  Contains 3 VWFC domains &  Contains 4 VWFD domains


uniprot_information_type:
SwissProt: P98088 # The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding# Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 2 VWFC domains &  Contains 4 VWFD domains

uniprot_information:
SwissProt: P98088 # The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding# Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 2 VWFC domains &  Contains 4 VWFD domains


uniprot_information_type: SwissProt: Q8IWQ3
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P51787 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily

uniprot_information:
SwissProt: P51787 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily


uniprot_information_type:
SwissProt: Q9NRE1 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family

uniprot_information:
SwissProt: Q9NRE1 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family


uniprot_information_type:
SwissProt: Q8IYM9 # The C-terminal SPRY domain is required for the transcriptional suppressor activity, probably by mediating correct nuclear localization. Residues 491-494 are essential for nuclear localization and nuclear bodies formation &  The RING domain is essential for antiviral activity and for TRIM22 nuclear bodies (NB) formation but is not necessary for nuclear localization# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8IYM9 # The C-terminal SPRY domain is required for the transcriptional suppressor activity, probably by mediating correct nuclear localization. Residues 491-494 are essential for nuclear localization and nuclear bodies formation &  The RING domain is essential for antiviral activity and for TRIM22 nuclear bodies (NB) formation but is not necessary for nuclear localization# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9Y5J6 # The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of FXC1/TIM10B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity)# Belongs to the small Tim family

uniprot_information:
SwissProt: Q9Y5J6 # The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of FXC1/TIM10B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity)# Belongs to the small Tim family


uniprot_information_type:
SwissProt: Q13418 # A PH-like domain is involved in phosphatidylinositol phosphate binding# Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 5 ANK repeats &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q13418 # A PH-like domain is involved in phosphatidylinositol phosphate binding# Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 5 ANK repeats &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9UL58
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 4 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type:
SwissProt: Q8ND30 # The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha (By similarity)# Belongs to the liprin family. Liprin-beta subfamily &  Contains 3 SAM (sterile alpha motif) domains

uniprot_information:
SwissProt: Q8ND30 # The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha (By similarity)# Belongs to the liprin family. Liprin-beta subfamily &  Contains 3 SAM (sterile alpha motif) domains


uniprot_information_type: SwissProt: P30291
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9UH65 # The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding# Contains 1 PH domain

uniprot_information:
SwissProt: Q9UH65 # The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding# Contains 1 PH domain


uniprot_information_type:
SwissProt: O94851 # The C-terminal coiled coil part contains the plexin-interacting region# Contains 1 CH (calponin-homology) domain &  Contains 1 LIM zinc-binding domain

uniprot_information:
SwissProt: O94851 # The C-terminal coiled coil part contains the plexin-interacting region# Contains 1 CH (calponin-homology) domain &  Contains 1 LIM zinc-binding domain


uniprot_information_type:
SwissProt: P48547 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily

uniprot_information:
SwissProt: P48547 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily


uniprot_information_type:
SwissProt: Q8IUH4 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily &  Contains 6 ANK repeats &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q8IUH4 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily &  Contains 6 ANK repeats &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: O60678 # The zinc-finger is responsible for substrate specificity (By similarity)# Belongs to the protein arginine N-methyltransferase family &  Contains 1 C2H2-type zinc finger

uniprot_information:
SwissProt: O60678 # The zinc-finger is responsible for substrate specificity (By similarity)# Belongs to the protein arginine N-methyltransferase family &  Contains 1 C2H2-type zinc finger


uniprot_information_type:
SwissProt: Q9NZC4 # The PNT domain acts as a transcriptional activator (By similarity)# Belongs to the ETS family &  Contains 1 ETS DNA-binding domain &  Contains 1 PNT (pointed) domain

uniprot_information:
SwissProt: Q9NZC4 # The PNT domain acts as a transcriptional activator (By similarity)# Belongs to the ETS family &  Contains 1 ETS DNA-binding domain &  Contains 1 PNT (pointed) domain


uniprot_information_type:
SwissProt: P15918 # The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity (By similarity) &  The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp (By similarity)# Belongs to the RAG1 family &  Contains 1 NBD (nonamer binding) DNA-binding domain &  Contains 1 RAG1-type zinc finger &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: P15918 # The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity (By similarity) &  The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp (By similarity)# Belongs to the RAG1 family &  Contains 1 NBD (nonamer binding) DNA-binding domain &  Contains 1 RAG1-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9BZZ5 # Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2# Belongs to the API5 family

uniprot_information:
SwissProt: Q9BZZ5 # Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2# Belongs to the API5 family


uniprot_information_type:
SwissProt: Q53GQ0 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily

uniprot_information:
SwissProt: Q53GQ0 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily


uniprot_information_type:
SwissProt: Q9UQF2 # The destruction boxes (D-box) may act as recognition signals for degradation via the ubiquitin-proteasome pathway &  A minimal inhibitory domain prevents pancreatic beta cell apoptosis in vitro, and prevents activation of c-jun by MAPK8, MAPK9 and MAPK10# Belongs to the JIP scaffold family &  Contains 1 PID domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q9UQF2 # The destruction boxes (D-box) may act as recognition signals for degradation via the ubiquitin-proteasome pathway &  A minimal inhibitory domain prevents pancreatic beta cell apoptosis in vitro, and prevents activation of c-jun by MAPK8, MAPK9 and MAPK10# Belongs to the JIP scaffold family &  Contains 1 PID domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: P00734
uniprot_information:
Belongs to the peptidase S1 family &  Contains 1 Gla (gamma-carboxy-glutamate) domain &  Contains 2 kringle domains &  Contains 1 peptidase S1 domain


uniprot_information_type:
SwissProt: Q92466 # The DWD box is required for interaction with DDB1# Belongs to the WD repeat DDB2/WDR76 family &  Contains 5 WD repeats

uniprot_information:
SwissProt: Q92466 # The DWD box is required for interaction with DDB1# Belongs to the WD repeat DDB2/WDR76 family &  Contains 5 WD repeats


uniprot_information_type: SwissProt: Q8WXG6
uniprot_information:
Belongs to the MADD family &  Contains 1 dDENN domain &  Contains 1 death domain &  Contains 1 DENN domain &  Contains 1 uDENN domain


uniprot_information_type: SwissProt: Q12913
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily &  Contains 9 fibronectin type-III domains &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: Q9Y320 # The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity (By similarity) &  The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Contains 1 thioredoxin domain

uniprot_information:
SwissProt: Q9Y320 # The thioredoxin domain lacks the 2 redox-active cysteines, suggesting that it lacks thioredoxin activity (By similarity) &  The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Contains 1 thioredoxin domain


uniprot_information_type:
SwissProt: O60716 # A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted# Belongs to the beta-catenin family &  Contains 10 ARM repeats

uniprot_information:
SwissProt: O60716 # A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted# Belongs to the beta-catenin family &  Contains 10 ARM repeats


uniprot_information_type:
SwissProt: Q9Y2E6 # The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases (By similarity)# Belongs to the Deltex family &  Contains 1 RING-type zinc finger &  Contains 2 WWE domains

uniprot_information:
SwissProt: Q9Y2E6 # The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases (By similarity)# Belongs to the Deltex family &  Contains 1 RING-type zinc finger &  Contains 2 WWE domains


uniprot_information_type:
SwissProt: Q96HJ5 # The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity# Belongs to the MS4A family

uniprot_information:
SwissProt: Q96HJ5 # The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity# Belongs to the MS4A family


uniprot_information_type: SwissProt: Q3LXA3
uniprot_information:
Belongs to the dihydroxyacetone kinase (DAK) family &  Contains 1 DhaK domain &  Contains 1 DhaL domain


uniprot_information_type:
SwissProt: Q9Y2G1 # A transmembrane region is predicted by sequence analysis tools. However, the protein is nuclear and probably acts as a transcription factor. It is therefore unclear whether the predicted transmembrane region is a hydrophobic region that does not insert into membranes or whether it is a real transmembrane region that may be cleaved when acting as transcription regulator# Belongs to the MRF family &  Contains 1 NDT80 DNA-binding domain

uniprot_information:
SwissProt: Q9Y2G1 # A transmembrane region is predicted by sequence analysis tools. However, the protein is nuclear and probably acts as a transcription factor. It is therefore unclear whether the predicted transmembrane region is a hydrophobic region that does not insert into membranes or whether it is a real transmembrane region that may be cleaved when acting as transcription regulator# Belongs to the MRF family &  Contains 1 NDT80 DNA-binding domain


uniprot_information_type:
SwissProt: O95864 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the fatty acid desaturase family &  Contains 1 cytochrome b5 heme-binding domain

uniprot_information:
SwissProt: O95864 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the fatty acid desaturase family &  Contains 1 cytochrome b5 heme-binding domain


uniprot_information_type:
SwissProt: Q96FW1 # In addition to ubiquitin-binding at the Cys-91 active site, a proximal ubiquitin-binding site is also present at Cys-23 Occupancy of the active site is needed to enable tight binding to the second site. Distinct binding sites for the ubiquitins may allow to discriminate among different isopeptide linkages (i.e. 'Lys-48'-, 'Lys-63'-linked polyubiquitin) in polyubiquitin substrates and achieve linkage-specific deubiquitination# Belongs to the peptidase C65 family &  Contains 1 OTU domain

uniprot_information:
SwissProt: Q96FW1 # In addition to ubiquitin-binding at the Cys-91 active site, a proximal ubiquitin-binding site is also present at Cys-23 Occupancy of the active site is needed to enable tight binding to the second site. Distinct binding sites for the ubiquitins may allow to discriminate among different isopeptide linkages (i.e. 'Lys-48'-, 'Lys-63'-linked polyubiquitin) in polyubiquitin substrates and achieve linkage-specific deubiquitination# Belongs to the peptidase C65 family &  Contains 1 OTU domain


uniprot_information_type:
SwissProt: P31948 # The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90# Contains 2 STI1 domains &  Contains 9 TPR repeats

uniprot_information:
SwissProt: P31948 # The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90# Contains 2 STI1 domains &  Contains 9 TPR repeats


uniprot_information_type: SwissProt: Q9NRS6
uniprot_information:
Belongs to the sorting nexin family &  Contains 1 MIT domain &  Contains 1 PX (phox homology) domain


uniprot_information_type:
SwissProt: O95159 # The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein# Belongs to the ZFPL1 family &  Contains 1 B box-type zinc finger &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: O95159 # The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein# Belongs to the ZFPL1 family &  Contains 1 B box-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: P07384
uniprot_information:
Belongs to the peptidase C2 family &  Contains 1 calpain catalytic domain &  Contains 4 EF-hand domains


uniprot_information_type:
SwissProt: Q14181 # The N-terminal 240 amino acids are sufficient to mediate complex formation# Belongs to the DNA polymerase alpha subunit B family

uniprot_information:
SwissProt: Q14181 # The N-terminal 240 amino acids are sufficient to mediate complex formation# Belongs to the DNA polymerase alpha subunit B family


uniprot_information_type:
SwissProt: O14613 # The CRIB domain mediates interaction with CDC42# Belongs to the BORG/CEP family &  Contains 1 CRIB domain

uniprot_information:
SwissProt: O14613 # The CRIB domain mediates interaction with CDC42# Belongs to the BORG/CEP family &  Contains 1 CRIB domain


uniprot_information_type: SwissProt: Q92785
uniprot_information:
Belongs to the requiem/DPF family &  Contains 1 C2H2-type zinc finger &  Contains 2 PHD-type zinc fingers


uniprot_information_type:
SwissProt: O75531 # Has a helix-hairpin-helix (HhH) structural motif conserved among proteins that bind non-specifically to DNA &  LEM domain proteins bind centrally on the BAF dimer, whereas DNA binds to the left and right sides# Belongs to the BAF family

uniprot_information:
SwissProt: O75531 # Has a helix-hairpin-helix (HhH) structural motif conserved among proteins that bind non-specifically to DNA &  LEM domain proteins bind centrally on the BAF dimer, whereas DNA binds to the left and right sides# Belongs to the BAF family


uniprot_information_type: SwissProt: O14618
uniprot_information:
In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family &  Contains 1 HMA domain


uniprot_information_type:
SwissProt: Q6PJG9 # The PDZ-binding motif is required for neurite outgrowth promotion (By similarity). This motif is also involved in DLG1-, DLG3- and DLG4-binding# Belongs to the LRFN family &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 7 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q6PJG9 # The PDZ-binding motif is required for neurite outgrowth promotion (By similarity). This motif is also involved in DLG1-, DLG3- and DLG4-binding# Belongs to the LRFN family &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 7 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q9Y2K7 # The JmjC domain mediates demethylation activity and is required for satellite silencing &  The CXXC zinc finger preferentially recognizes nonmethylated CpG DNA, and binding is blocked when the CpG DNA is methylated# Belongs to the JHDM1 histone demethylase family &  Contains 1 CXXC-type zinc finger &  Contains 1 F-box domain &  Contains 1 JmjC domain &  Contains 3 LRR (leucine-rich) repeats &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: Q9Y2K7 # The JmjC domain mediates demethylation activity and is required for satellite silencing &  The CXXC zinc finger preferentially recognizes nonmethylated CpG DNA, and binding is blocked when the CpG DNA is methylated# Belongs to the JHDM1 histone demethylase family &  Contains 1 CXXC-type zinc finger &  Contains 1 F-box domain &  Contains 1 JmjC domain &  Contains 3 LRR (leucine-rich) repeats &  Contains 1 PHD-type zinc finger


uniprot_information_type: SwissProt: P25098
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 protein kinase domain &  Contains 1 RGS domain


uniprot_information_type: SwissProt: Q9UBS0
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: P09211
uniprot_information:
Belongs to the GST superfamily. Pi family &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain


uniprot_information_type: SwissProt: O75197
uniprot_information:
Belongs to the LDLR family &  Contains 4 EGF-like domains &  Contains 3 LDL-receptor class A domains &  Contains 20 LDL-receptor class B repeats


uniprot_information_type: SwissProt: P38935
uniprot_information:
Belongs to the DNA2/NAM7 helicase family &  Contains 1 AN1-type zinc finger &  Contains 1 R3H domain


uniprot_information_type:
SwissProt: Q5XXA6 # The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region (By similarity)# Belongs to the anoctamin family

uniprot_information:
SwissProt: Q5XXA6 # The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region (By similarity)# Belongs to the anoctamin family


uniprot_information_type:
SwissProt: Q13158 # Contains a death domain involved in the binding of the corresponding domain within Fas receptor# Contains 1 death domain &  Contains 1 DED (death effector) domain

uniprot_information:
SwissProt: Q13158 # Contains a death domain involved in the binding of the corresponding domain within Fas receptor# Contains 1 death domain &  Contains 1 DED (death effector) domain


uniprot_information_type:
SwissProt: Q13136 # The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS# Belongs to the liprin family. Liprin-alpha subfamily &  Contains 3 SAM (sterile alpha motif) domains

uniprot_information:
SwissProt: Q13136 # The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS# Belongs to the liprin family. Liprin-alpha subfamily &  Contains 3 SAM (sterile alpha motif) domains


uniprot_information_type:
SwissProt: O15357 # The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or FCGR2A. It also mediates the interaction with p130Cas/BCAR1 &  The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain (By similarity)# Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family &  Contains 1 SAM (sterile alpha motif) domain &  Contains 1 SH2 domain

uniprot_information:
SwissProt: O15357 # The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or FCGR2A. It also mediates the interaction with p130Cas/BCAR1 &  The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain (By similarity)# Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family &  Contains 1 SAM (sterile alpha motif) domain &  Contains 1 SH2 domain


uniprot_information_type: SwissProt: Q13402
uniprot_information:
Contains 2 FERM domains &  Contains 5 IQ domains &  Contains 1 myosin head-like domain &  Contains 2 MyTH4 domains &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q9Y3Q0 # The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal# Belongs to the peptidase M28 family. M28B subfamily

uniprot_information:
SwissProt: Q9Y3Q0 # The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal# Belongs to the peptidase M28 family. M28B subfamily


uniprot_information_type:
SwissProt: Q86XR8 # The C-terminal region mediates the interaction with microtubules and is able to nucleate and bundles microtubules in vitro (By similarity) &  The centrosome localization domain (CLD) region mediates the localization to centrosomes and homooligomerization (By similarity)# Belongs to the translokin family

uniprot_information:
SwissProt: Q86XR8 # The C-terminal region mediates the interaction with microtubules and is able to nucleate and bundles microtubules in vitro (By similarity) &  The centrosome localization domain (CLD) region mediates the localization to centrosomes and homooligomerization (By similarity)# Belongs to the translokin family


uniprot_information_type: SwissProt: Q9Y4A0
uniprot_information:
Belongs to the tigger transposable element derived protein family &  Contains 1 DDE domain &  Contains 1 HTH CENPB-type DNA-binding domain &  Contains 1 HTH psq-type DNA-binding domain


uniprot_information_type: SwissProt: Q13489
uniprot_information:
Belongs to the IAP family &  Contains 3 BIR repeats &  Contains 1 CARD domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q13315 # The FATC domain is required for interaction with KAT5# Belongs to the PI3/PI4-kinase family. ATM subfamily &  Contains 1 FAT domain &  Contains 1 FATC domain &  Contains 1 PI3K/PI4K domain

uniprot_information:
SwissProt: Q13315 # The FATC domain is required for interaction with KAT5# Belongs to the PI3/PI4-kinase family. ATM subfamily &  Contains 1 FAT domain &  Contains 1 FATC domain &  Contains 1 PI3K/PI4K domain


uniprot_information_type:
SwissProt: Q13206 # The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis# Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain

uniprot_information:
SwissProt: Q13206 # The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis# Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q155Q3 # The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation through MAP3K4 &  The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1-mediated JNK activation through MAP3K1. Probably also mediates interaction with DVL2# Belongs to the DIXDC1 family &  Contains 1 CH (calponin-homology) domain &  Contains 1 DIX domain

uniprot_information:
SwissProt: Q155Q3 # The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation through MAP3K4 &  The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1-mediated JNK activation through MAP3K1. Probably also mediates interaction with DVL2# Belongs to the DIXDC1 family &  Contains 1 CH (calponin-homology) domain &  Contains 1 DIX domain


uniprot_information_type: SwissProt: O95264
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily


uniprot_information_type: SwissProt: P46098
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily


uniprot_information_type: SwissProt: Q05516
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 9 C2H2-type zinc fingers


uniprot_information_type: SwissProt: P68402
uniprot_information:
Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily


uniprot_information_type: SwissProt: Q9NRS4
uniprot_information:
Belongs to the peptidase S1 family &  Contains 1 LDL-receptor class A domain &  Contains 1 peptidase S1 domain &  Contains 1 SRCR domain


uniprot_information_type:
SwissProt: P09693 # A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes# Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 1 ITAM domain

uniprot_information:
SwissProt: P09693 # A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes# Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 1 ITAM domain


uniprot_information_type:
SwissProt: Q03164 # The SET domain structure is atypical and is not in an optimal position to have methyltransferase activity. It requires other components of the MLL1/MLL complex, such as ASH2L or RBBP5, to order the active site and obtain optimal histone methyltransferase activity &  The CXXC-type zinc finger binds bind to nonmethyl-CpG dinucleotides# Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily &  Contains 3 A.T hook DNA-binding domains &  Contains 1 bromo domain &  Contains 1 CXXC-type zinc finger &  Contains 1 FY-rich C-terminal domain &  Contains 1 FY-rich N-terminal domain &  Contains 3 PHD-type zinc fingers &  Contains 1 post-SET domain &  Contains 1 SET domain

uniprot_information:
SwissProt: Q03164 # The SET domain structure is atypical and is not in an optimal position to have methyltransferase activity. It requires other components of the MLL1/MLL complex, such as ASH2L or RBBP5, to order the active site and obtain optimal histone methyltransferase activity &  The CXXC-type zinc finger binds bind to nonmethyl-CpG dinucleotides# Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily &  Contains 3 A.T hook DNA-binding domains &  Contains 1 bromo domain &  Contains 1 CXXC-type zinc finger &  Contains 1 FY-rich C-terminal domain &  Contains 1 FY-rich N-terminal domain &  Contains 3 PHD-type zinc fingers &  Contains 1 post-SET domain &  Contains 1 SET domain


uniprot_information_type: SwissProt: P48444
uniprot_information:
Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily &  Contains 1 MHD (mu homology) domain


uniprot_information_type:
SwissProt: Q86UU1 # The PH domain mediates the binding to phosphoinositides# Contains 1 FHA domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q86UU1 # The PH domain mediates the binding to phosphoinositides# Contains 1 FHA domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: P22681 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme &  The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain# Contains 1 CBL N-terminal domain &  Contains 2 EF-hand-like domains &  Contains 1 RING-type zinc finger &  Contains 1 SH2 domain &  Contains 1 UBA domain

uniprot_information:
SwissProt: P22681 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme &  The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain# Contains 1 CBL N-terminal domain &  Contains 2 EF-hand-like domains &  Contains 1 RING-type zinc finger &  Contains 1 SH2 domain &  Contains 1 UBA domain


uniprot_information_type: SwissProt: Q9NZN5
uniprot_information:
Contains 1 DH (DBL-homology) domain &  Contains 1 PDZ (DHR) domain &  Contains 1 PH domain &  Contains 1 RGSL (RGS-like) domain


uniprot_information_type:
SwissProt: O75443 # Zona pellucida domain may enable to form filaments# Contains 1 NIDO domain &  Contains 3 TIL (trypsin inhibitory-like) domains &  Contains 1 VWFC domain &  Contains 4 VWFD domains &  Contains 1 ZP domain

uniprot_information:
SwissProt: O75443 # Zona pellucida domain may enable to form filaments# Contains 1 NIDO domain &  Contains 3 TIL (trypsin inhibitory-like) domains &  Contains 1 VWFC domain &  Contains 4 VWFD domains &  Contains 1 ZP domain


uniprot_information_type:
SwissProt: O75845 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the sterol desaturase family

uniprot_information:
SwissProt: O75845 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the sterol desaturase family


uniprot_information_type: SwissProt: Q92673
uniprot_information:
Belongs to the SORL1 family &  Contains 5 BNR repeats &  Contains 1 EGF-like domain &  Contains 6 fibronectin type-III domains &  Contains 11 LDL-receptor class A domains &  Contains 5 LDL-receptor class B repeats


uniprot_information_type: SwissProt: O95727
uniprot_information:
Belongs to the nectin family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: Q9UHL0
uniprot_information:
Belongs to the DEAD box helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: Q9Y5Y6
uniprot_information:
Belongs to the peptidase S1 family &  Contains 2 CUB domains &  Contains 4 LDL-receptor class A domains &  Contains 1 peptidase S1 domain


uniprot_information_type: SwissProt: Q9BX67
uniprot_information:
Belongs to the immunoglobulin superfamily &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: P29375 # The GSGFP motif is required for the interaction with SUZ12 (By similarity)# Belongs to the JARID1 histone demethylase family &  Contains 1 ARID domain &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 3 PHD-type zinc fingers

uniprot_information:
SwissProt: P29375 # The GSGFP motif is required for the interaction with SUZ12 (By similarity)# Belongs to the JARID1 histone demethylase family &  Contains 1 ARID domain &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 3 PHD-type zinc fingers


uniprot_information_type:
SwissProt: Q08050 # Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4# Contains 1 fork-head DNA-binding domain

uniprot_information:
SwissProt: Q08050 # Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4# Contains 1 fork-head DNA-binding domain


uniprot_information_type:
SwissProt: O75969 # RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Belongs to the AKAP110 family

uniprot_information:
SwissProt: O75969 # RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Belongs to the AKAP110 family


uniprot_information_type:
SwissProt: P04275 # The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules# Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 4 TIL (trypsin inhibitory-like) domains &  Contains 3 VWFA domains &  Contains 3 VWFC domains &  Contains 4 VWFD domains

uniprot_information:
SwissProt: P04275 # The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules# Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 4 TIL (trypsin inhibitory-like) domains &  Contains 3 VWFA domains &  Contains 3 VWFC domains &  Contains 4 VWFD domains


uniprot_information_type:
SwissProt: P19438 # The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE &  Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP (By similarity)# Contains 1 death domain &  Contains 4 TNFR-Cys repeats

uniprot_information:
SwissProt: P19438 # The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE &  Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP (By similarity)# Contains 1 death domain &  Contains 4 TNFR-Cys repeats


uniprot_information_type:
SwissProt: Q99618 # The KEN box is required for the association with the APC/C-Cdh1 complex (By similarity)#

uniprot_information:
SwissProt: Q99618 # The KEN box is required for the association with the APC/C-Cdh1 complex (By similarity)#


uniprot_information_type:
SwissProt: Q6P1A2 # The di-lysine motif confers endoplasmic reticulum localization# Belongs to the membrane-bound acyltransferase family

uniprot_information:
SwissProt: Q6P1A2 # The di-lysine motif confers endoplasmic reticulum localization# Belongs to the membrane-bound acyltransferase family


uniprot_information_type:
SwissProt: Q86VB7 # The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes# Contains 9 SRCR domains

uniprot_information:
SwissProt: Q86VB7 # The SRCR domain 3 mediates calcium-sensitive interaction with hemoglobin/haptoglobin complexes# Contains 9 SRCR domains


uniprot_information_type:
SwissProt: P20645 # The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor#

uniprot_information:
SwissProt: P20645 # The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor#


uniprot_information_type:
SwissProt: P78380 # The cytoplasmic region is required for subcellular sorting on the cell surface &  The C-type lectin domain mediates the recognition and binding of oxLDL# Contains 1 C-type lectin domain

uniprot_information:
SwissProt: P78380 # The cytoplasmic region is required for subcellular sorting on the cell surface &  The C-type lectin domain mediates the recognition and binding of oxLDL# Contains 1 C-type lectin domain


uniprot_information_type:
SwissProt: O75581 # The YWTD-EGF-like domains 1 and 2 are required for the interaction with Wnt-frizzled complex. The YWTD-EGF-like domains 3 and 4 are required for the interaction with DKK1 &  The PPPSP motifs play a central role in signal transduction by being phosphorylated, leading to activate the Wnt signaling pathway# Belongs to the LDLR family &  Contains 4 EGF-like domains &  Contains 3 LDL-receptor class A domains &  Contains 20 LDL-receptor class B repeats

uniprot_information:
SwissProt: O75581 # The YWTD-EGF-like domains 1 and 2 are required for the interaction with Wnt-frizzled complex. The YWTD-EGF-like domains 3 and 4 are required for the interaction with DKK1 &  The PPPSP motifs play a central role in signal transduction by being phosphorylated, leading to activate the Wnt signaling pathway# Belongs to the LDLR family &  Contains 4 EGF-like domains &  Contains 3 LDL-receptor class A domains &  Contains 20 LDL-receptor class B repeats


uniprot_information_type:
SwissProt: P25092 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the adenylyl cyclase class-4/guanylyl cyclase family &  Contains 1 guanylate cyclase domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P25092 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the adenylyl cyclase class-4/guanylyl cyclase family &  Contains 1 guanylate cyclase domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: P08493
uniprot_information:
Belongs to the osteocalcin/matrix Gla protein family &  Contains 1 Gla (gamma-carboxy-glutamate) domain


uniprot_information_type:
SwissProt: Q12929 # The SH3 domain mediates interaction with SHB# Belongs to the EPS8 family &  Contains 1 PH domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q12929 # The SH3 domain mediates interaction with SHB# Belongs to the EPS8 family &  Contains 1 PH domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: P46063
uniprot_information:
Belongs to the helicase family. RecQ subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q14571 # The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region# Belongs to the InsP3 receptor family &  Contains 5 MIR domains

uniprot_information:
SwissProt: Q14571 # The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region# Belongs to the InsP3 receptor family &  Contains 5 MIR domains


uniprot_information_type: SwissProt: Q86SJ2
uniprot_information:
Belongs to the immunoglobulin superfamily. AMIGO family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 6 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: O95398 # The DEP domain is involved in membrane localization independent from regulation by cAMP# Contains 1 cyclic nucleotide-binding domain &  Contains 1 DEP domain &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 Ras-GEF domain

uniprot_information:
SwissProt: O95398 # The DEP domain is involved in membrane localization independent from regulation by cAMP# Contains 1 cyclic nucleotide-binding domain &  Contains 1 DEP domain &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 Ras-GEF domain


uniprot_information_type:
SwissProt: Q8WUI4 # The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm (By similarity)# Belongs to the histone deacetylase family. Type 2 subfamily

uniprot_information:
SwissProt: Q8WUI4 # The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm (By similarity)# Belongs to the histone deacetylase family. Type 2 subfamily


uniprot_information_type:
SwissProt: P11473 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P11473 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: Q9H765 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 4 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q9H765 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 4 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q9BUQ8
uniprot_information:
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: O14686 # LXXLL motifs 5 and 5 are essential for the association with ESR1 nuclear receptor# Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily &  Contains 5 PHD-type zinc fingers &  Contains 1 post-SET domain &  Contains 1 RING-type zinc finger &  Contains 1 SET domain

uniprot_information:
SwissProt: O14686 # LXXLL motifs 5 and 5 are essential for the association with ESR1 nuclear receptor# Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily &  Contains 5 PHD-type zinc fingers &  Contains 1 post-SET domain &  Contains 1 RING-type zinc finger &  Contains 1 SET domain


uniprot_information_type:
SwissProt: Q9H0H5 # The coiled coil region is indispensible for localization to the midbody during cytokinesis# Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 Rho-GAP domain

uniprot_information:
SwissProt: Q9H0H5 # The coiled coil region is indispensible for localization to the midbody during cytokinesis# Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 Rho-GAP domain


uniprot_information_type:
SwissProt: Q9UHB6 # Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus# Contains 1 LIM zinc-binding domain

uniprot_information:
SwissProt: Q9UHB6 # Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus# Contains 1 LIM zinc-binding domain


uniprot_information_type:
SwissProt: Q8NCL4 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q8NCL4 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: P26010 # Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding# Belongs to the integrin beta chain family &  Contains 1 VWFA domain

uniprot_information:
SwissProt: P26010 # Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding# Belongs to the integrin beta chain family &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: P13631 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P13631 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: Q12852 # Interacts with MBIP through the leucine-zipper motif# Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q12852 # Interacts with MBIP through the leucine-zipper motif# Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9P1Z2 # The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity) &  The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By similarity) &  Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators (By similarity)# Belongs to the CALCOCO family

uniprot_information:
SwissProt: Q9P1Z2 # The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity) &  The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By similarity) &  Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators (By similarity)# Belongs to the CALCOCO family


uniprot_information_type:
SwissProt: Q16621 # The PXY motifs are required for binding WW domains. PXY1 is required to promote transactivation of beta-globin and for hyperacetylation of histone H3, but not for binding to the HS2 promoter site (By similarity)# Belongs to the bZIP family. CNC subfamily &  Contains 1 bZIP domain

uniprot_information:
SwissProt: Q16621 # The PXY motifs are required for binding WW domains. PXY1 is required to promote transactivation of beta-globin and for hyperacetylation of histone H3, but not for binding to the HS2 promoter site (By similarity)# Belongs to the bZIP family. CNC subfamily &  Contains 1 bZIP domain


uniprot_information_type:
SwissProt: Q99542 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: Q99542 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: P40967 # The RPT domain is essential for the generation of the fibrillar matrix of melanosomes &  The lumenal domain is necessary for correct processing and trafficking to melanosomes# Belongs to the Pmel-17/NMB family &  Contains 1 PKD domain

uniprot_information:
SwissProt: P40967 # The RPT domain is essential for the generation of the fibrillar matrix of melanosomes &  The lumenal domain is necessary for correct processing and trafficking to melanosomes# Belongs to the Pmel-17/NMB family &  Contains 1 PKD domain


uniprot_information_type:
SwissProt: P30301 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family

uniprot_information:
SwissProt: P30301 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family


uniprot_information_type:
SwissProt: Q9UIF9 # The bromo domain and the PHD-type zinc finger recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac). These 2 domains play a central role in the recritment of chromatin silencing proteins such as DNMT1, DNMT3B and HDAC1 &  The MBD (methyl-CpG-binding) domain, also named TAM domain, specifically recognizes and binds a conserved stem-loop structure the association within pRNA. Binding to pRNA induces a conformational change of BAZ2A/TIP5 and is essential for targeting the NoRC complex to the nucleolus (By similarity)# Belongs to the WAL family &  Contains 4 A.T hook DNA-binding domains &  Contains 1 bromo domain &  Contains 1 DDT domain &  Contains 1 MBD (methyl-CpG-binding) domain &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: Q9UIF9 # The bromo domain and the PHD-type zinc finger recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac). These 2 domains play a central role in the recritment of chromatin silencing proteins such as DNMT1, DNMT3B and HDAC1 &  The MBD (methyl-CpG-binding) domain, also named TAM domain, specifically recognizes and binds a conserved stem-loop structure the association within pRNA. Binding to pRNA induces a conformational change of BAZ2A/TIP5 and is essential for targeting the NoRC complex to the nucleolus (By similarity)# Belongs to the WAL family &  Contains 4 A.T hook DNA-binding domains &  Contains 1 bromo domain &  Contains 1 DDT domain &  Contains 1 MBD (methyl-CpG-binding) domain &  Contains 1 PHD-type zinc finger


uniprot_information_type:
SwissProt: Q99490 # G domain binds GTP and has GTPase activity &  Arf-GAP domain interacts with G domain and may regulate its GTPase activity &  Although both PH domains of isoforms 1 and 2 bind phospholipids, they differently regulate subcellular location. PH domain of isoform 1 directs the protein to the nucleus, but PH domain of isoform 2 directs it to the cytosol. PH domain of isoform 2 is required for binding to AP-1# Belongs to the centaurin gamma-like family &  Contains 2 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q99490 # G domain binds GTP and has GTPase activity &  Arf-GAP domain interacts with G domain and may regulate its GTPase activity &  Although both PH domains of isoforms 1 and 2 bind phospholipids, they differently regulate subcellular location. PH domain of isoform 1 directs the protein to the nucleus, but PH domain of isoform 2 directs it to the cytosol. PH domain of isoform 2 is required for binding to AP-1# Belongs to the centaurin gamma-like family &  Contains 2 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q9Y3R0 # PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1 and EPHB2 and with the C-terminus of PPFIA1 and PPFIA4. PDZ 4 and PDZ 5 mediate interaction with the C-terminus of GRIA2 and GRIA3. PDZ 4, PDZ 5 and PDZ 6 mediate homomultimers. PDZ 7 mediates interaction with PDZ domain of GRASP1. PDZ 7 domain binds CSPG4. PDZ 6 mediates interaction with the C-terminus of liprins-alpha. PDZ 1, PDZ 2 and PDZ 3 mediate interaction with the PDZ-binding motif of FRAS1 (By similarity). PDZ 4 and PDZ 5 mediate interaction with PRLHR# Contains 7 PDZ (DHR) domains

uniprot_information:
SwissProt: Q9Y3R0 # PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1 and EPHB2 and with the C-terminus of PPFIA1 and PPFIA4. PDZ 4 and PDZ 5 mediate interaction with the C-terminus of GRIA2 and GRIA3. PDZ 4, PDZ 5 and PDZ 6 mediate homomultimers. PDZ 7 mediates interaction with PDZ domain of GRASP1. PDZ 7 domain binds CSPG4. PDZ 6 mediates interaction with the C-terminus of liprins-alpha. PDZ 1, PDZ 2 and PDZ 3 mediate interaction with the PDZ-binding motif of FRAS1 (By similarity). PDZ 4 and PDZ 5 mediate interaction with PRLHR# Contains 7 PDZ (DHR) domains


uniprot_information_type: SwissProt: P23467
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily &  Contains 17 fibronectin type-III domains &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type: SwissProt: Q15256
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: P55209 # The acidic domains are probably involved in the interaction with histones# Belongs to the nucleosome assembly protein (NAP) family

uniprot_information:
SwissProt: P55209 # The acidic domains are probably involved in the interaction with histones# Belongs to the nucleosome assembly protein (NAP) family


uniprot_information_type:
SwissProt: Q96IZ0 # The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners (By similarity) &  The SAC domain is a death-inducing domain selective for apoptosis induction in cancer cells. This domain is essential for nuclear entry, Fas activation, inhibition of NF-kappa-B activity and induction of apoptosis in cancer cells (By similarity)#

uniprot_information:
SwissProt: Q96IZ0 # The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners (By similarity) &  The SAC domain is a death-inducing domain selective for apoptosis induction in cancer cells. This domain is essential for nuclear entry, Fas activation, inhibition of NF-kappa-B activity and induction of apoptosis in cancer cells (By similarity)#


uniprot_information_type:
SwissProt: O14974 # Heterotetramerization is mediated by the interaction between a coiled-coil of PRKG1 and the leucine/isoleucine zipper of PPP1R12A/MBS, the myosin-binding subunit of the myosin phosphatase (By similarity)# Contains 6 ANK repeats

uniprot_information:
SwissProt: O14974 # Heterotetramerization is mediated by the interaction between a coiled-coil of PRKG1 and the leucine/isoleucine zipper of PPP1R12A/MBS, the myosin-binding subunit of the myosin phosphatase (By similarity)# Contains 6 ANK repeats


uniprot_information_type:
SwissProt: O14910 # The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane &  The PDZ domain regulates endocytosis and recycling of the receptor at the membrane &  The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes (By similarity)# Belongs to the lin-7 family &  Contains 1 L27 domain &  Contains 1 PDZ (DHR) domain

uniprot_information:
SwissProt: O14910 # The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane &  The PDZ domain regulates endocytosis and recycling of the receptor at the membrane &  The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes (By similarity)# Belongs to the lin-7 family &  Contains 1 L27 domain &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: O75334 # The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS# Belongs to the liprin family. Liprin-alpha subfamily &  Contains 3 SAM (sterile alpha motif) domains

uniprot_information:
SwissProt: O75334 # The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS# Belongs to the liprin family. Liprin-alpha subfamily &  Contains 3 SAM (sterile alpha motif) domains


uniprot_information_type:
SwissProt: Q8N4A0 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q8N4A0 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: P20020 # The calmodulin-binding subdomain B is different in the different splice variants and shows pH dependent calmodulin binding properties in isoforms A, C, D and E# Belongs to the cation transport ATPase (P-type) family. Type IIB subfamily

uniprot_information:
SwissProt: P20020 # The calmodulin-binding subdomain B is different in the different splice variants and shows pH dependent calmodulin binding properties in isoforms A, C, D and E# Belongs to the cation transport ATPase (P-type) family. Type IIB subfamily


uniprot_information_type:
SwissProt: Q15075 # The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate# Contains 1 C2H2-type zinc finger &  Contains 1 FYVE-type zinc finger

uniprot_information:
SwissProt: Q15075 # The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate# Contains 1 C2H2-type zinc finger &  Contains 1 FYVE-type zinc finger


uniprot_information_type:
SwissProt: P25208 # Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain# Belongs to the NFYB/HAP3 subunit family

uniprot_information:
SwissProt: P25208 # Can be divided into 3 domains: the weakly conserved A domain, the highly conserved B domain thought to be involved in subunit interaction and DNA binding, and the Glu-rich C domain# Belongs to the NFYB/HAP3 subunit family


uniprot_information_type: SwissProt: Q9HBA0
uniprot_information:
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily &  Contains 3 ANK repeats


uniprot_information_type: SwissProt: Q8TDD1
uniprot_information:
Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: P29475 # The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles. Mediates interaction with VAC14 (By similarity)# Belongs to the NOS family &  Contains 1 FAD-binding FR-type domain &  Contains 1 flavodoxin-like domain &  Contains 1 PDZ (DHR) domain

uniprot_information:
SwissProt: P29475 # The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles. Mediates interaction with VAC14 (By similarity)# Belongs to the NOS family &  Contains 1 FAD-binding FR-type domain &  Contains 1 flavodoxin-like domain &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: Q9NYS7 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SOCS box domain &  Contains 5 WD repeats

uniprot_information:
SwissProt: Q9NYS7 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SOCS box domain &  Contains 5 WD repeats


uniprot_information_type: SwissProt: O14578
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 CNH domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O43347 # The first RNA recognition motif binds more strongly to RNA compared to the second one (By similarity)# Belongs to the Musashi family &  Contains 2 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: O43347 # The first RNA recognition motif binds more strongly to RNA compared to the second one (By similarity)# Belongs to the Musashi family &  Contains 2 RRM (RNA recognition motif) domains


uniprot_information_type:
SwissProt: Q96RR4 # The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition &  The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates (By similarity)# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q96RR4 # The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition &  The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates (By similarity)# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9NP78
uniprot_information:
Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily &  Contains 1 ABC transmembrane type-1 domain &  Contains 1 ABC transporter domain


uniprot_information_type:
SwissProt: Q9Y618 # The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2) &  The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity# Belongs to the N-CoR nuclear receptor corepressors family &  Contains 2 SANT domains

uniprot_information:
SwissProt: Q9Y618 # The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2) &  The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity# Belongs to the N-CoR nuclear receptor corepressors family &  Contains 2 SANT domains


uniprot_information_type:
SwissProt: Q8N8A6 # The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis# Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain

uniprot_information:
SwissProt: Q8N8A6 # The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis# Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q07864 # The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is necessary for complexing subunits B and C. The C-terminus may also regulate the catalytic activities of the enzyme# Belongs to the DNA polymerase type-B family

uniprot_information:
SwissProt: Q07864 # The DNA polymerase activity domain resides in the N-terminal half of the protein, while the C-terminus is necessary for complexing subunits B and C. The C-terminus may also regulate the catalytic activities of the enzyme# Belongs to the DNA polymerase type-B family


uniprot_information_type:
SwissProt: Q96EP1 # The PBZ-type zinc finger (also named CYR) mediates non-covalent poly(ADP-ribose)-binding. Poly(ADP-ribose)-binding is dependent on the presence of zinc and is required for its function in antephase checkpoint &  The FHA domain plays a key role in the anti-proliferative properties of the protein and is involved in initiating a cell cycle arrest at G2/M. The FHA domain may be required to interact with phosphorylated proteins# Belongs to the CHFR family &  Contains 1 FHA domain &  Contains 1 PBZ-type zinc finger &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q96EP1 # The PBZ-type zinc finger (also named CYR) mediates non-covalent poly(ADP-ribose)-binding. Poly(ADP-ribose)-binding is dependent on the presence of zinc and is required for its function in antephase checkpoint &  The FHA domain plays a key role in the anti-proliferative properties of the protein and is involved in initiating a cell cycle arrest at G2/M. The FHA domain may be required to interact with phosphorylated proteins# Belongs to the CHFR family &  Contains 1 FHA domain &  Contains 1 PBZ-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q9H4A3
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q86V24 # The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular# Belongs to the ADIPOR family

uniprot_information:
SwissProt: Q86V24 # The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular# Belongs to the ADIPOR family


uniprot_information_type:
SwissProt: Q13936 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position &  Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel (By similarity)# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily

uniprot_information:
SwissProt: Q13936 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position &  Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel (By similarity)# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily


uniprot_information_type:
SwissProt: Q02790 # The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA) (By similarity) &  The C-terminal region (AA 375-458) is required to prevent tubulin polymerization (By similarity) &  The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400 (By similarity)# Contains 2 PPIase FKBP-type domains &  Contains 3 TPR repeats

uniprot_information:
SwissProt: Q02790 # The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA) (By similarity) &  The C-terminal region (AA 375-458) is required to prevent tubulin polymerization (By similarity) &  The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400 (By similarity)# Contains 2 PPIase FKBP-type domains &  Contains 3 TPR repeats


uniprot_information_type:
SwissProt: Q9NR22 # The SH3-binding motifs mediate the interaction with SH3 domain-containing proteins such as PRMT2 and FYN, possibly leading to displace the N-terminal domain and activate the protein &  The N-terminal region (1-60) inhibits the enzymatic activity# Belongs to the protein arginine N-methyltransferase family. PRMT8 subfamily

uniprot_information:
SwissProt: Q9NR22 # The SH3-binding motifs mediate the interaction with SH3 domain-containing proteins such as PRMT2 and FYN, possibly leading to displace the N-terminal domain and activate the protein &  The N-terminal region (1-60) inhibits the enzymatic activity# Belongs to the protein arginine N-methyltransferase family. PRMT8 subfamily


uniprot_information_type:
SwissProt: Q9NY28 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q9NY28 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: Q09470 # The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments &  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily

uniprot_information:
SwissProt: Q09470 # The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments &  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily


uniprot_information_type:
SwissProt: P22460 # The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments &  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily

uniprot_information:
SwissProt: P22460 # The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments &  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily


uniprot_information_type: SwissProt: Q9BX59
uniprot_information:
Contains 1 Ig-like C1-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q15021 # The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal, although they are contained within the same region# Belongs to the CND1 (condensin subunit 1) family

uniprot_information:
SwissProt: Q15021 # The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal, although they are contained within the same region# Belongs to the CND1 (condensin subunit 1) family


uniprot_information_type: SwissProt: P18627
uniprot_information:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P29350
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily &  Contains 2 SH2 domains &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: Q9BQT9 # Binds synaptic Ca(2+) with its cytoplasmic domain (By similarity)# Contains 2 cadherin domains

uniprot_information:
SwissProt: Q9BQT9 # Binds synaptic Ca(2+) with its cytoplasmic domain (By similarity)# Contains 2 cadherin domains


uniprot_information_type:
SwissProt: Q8NC96 # The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself. The WXXF motif 1, which is preceded by an acidic residue and has a glycine in second position mediates specific interaction with AP-1. The WXXF motif 2, which is followed by the C-terminal carboxyl group negative charge, allows specific interaction with AP-2 (By similarity)# Belongs to the NECAP family

uniprot_information:
SwissProt: Q8NC96 # The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself. The WXXF motif 1, which is preceded by an acidic residue and has a glycine in second position mediates specific interaction with AP-1. The WXXF motif 2, which is followed by the C-terminal carboxyl group negative charge, allows specific interaction with AP-2 (By similarity)# Belongs to the NECAP family


uniprot_information_type:
SwissProt: Q9UMR7 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 1 C-type lectin domain

uniprot_information:
SwissProt: Q9UMR7 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 1 C-type lectin domain


uniprot_information_type:
SwissProt: Q96E93 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D (By similarity)# Contains 1 C-type lectin domain

uniprot_information:
SwissProt: Q96E93 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. Upon phosphorylation of ITIM motif KLRG1 associates with the two phosphatases PTPN11 and INPP5D (By similarity)# Contains 1 C-type lectin domain


uniprot_information_type:
SwissProt: P46527 # A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2 inhibitory activity# Belongs to the CDI family

uniprot_information:
SwissProt: P46527 # A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2 inhibitory activity# Belongs to the CDI family


uniprot_information_type: SwissProt: Q9H0S4
uniprot_information:
Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q13956 # The C-terminal region is important in conferring inhibition (By similarity)# Belongs to the rod/cone cGMP-PDE gamma subunit family

uniprot_information:
SwissProt: Q13956 # The C-terminal region is important in conferring inhibition (By similarity)# Belongs to the rod/cone cGMP-PDE gamma subunit family


uniprot_information_type: SwissProt: Q16827
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily &  Contains 8 fibronectin type-III domains &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: P10997 # The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation# Belongs to the calcitonin family

uniprot_information:
SwissProt: P10997 # The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation# Belongs to the calcitonin family


uniprot_information_type:
SwissProt: Q8NFW8 # The BC2 (basic cluster 2) motif is necessary and sufficient for the nuclear localization and contains the catalytic active site. The localization in the nucleus is however not required for the enzyme activity (By similarity)# Belongs to the CMP-NeuNAc synthase family

uniprot_information:
SwissProt: Q8NFW8 # The BC2 (basic cluster 2) motif is necessary and sufficient for the nuclear localization and contains the catalytic active site. The localization in the nucleus is however not required for the enzyme activity (By similarity)# Belongs to the CMP-NeuNAc synthase family


uniprot_information_type:
SwissProt: Q86W92 # The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha and interaction with S100A4# Belongs to the liprin family. Liprin-beta subfamily &  Contains 3 SAM (sterile alpha motif) domains

uniprot_information:
SwissProt: Q86W92 # The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha and interaction with S100A4# Belongs to the liprin family. Liprin-beta subfamily &  Contains 3 SAM (sterile alpha motif) domains


uniprot_information_type: SwissProt: Q96FC9
uniprot_information:
Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily &  Contains 1 helicase ATP-binding domain


uniprot_information_type: SwissProt: Q9NWZ3
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily &  Contains 1 death domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P41181 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family

uniprot_information:
SwissProt: P41181 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family


uniprot_information_type:
SwissProt: P55064 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family

uniprot_information:
SwissProt: P55064 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family


uniprot_information_type:
SwissProt: Q13520 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family

uniprot_information:
SwissProt: Q13520 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family


uniprot_information_type: SwissProt: P18846
uniprot_information:
Belongs to the bZIP family. ATF subfamily &  Contains 1 bZIP domain &  Contains 1 KID (kinase-inducible) domain


uniprot_information_type:
SwissProt: Q9UQD0 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily &  Contains 1 IQ domain

uniprot_information:
SwissProt: Q9UQD0 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily &  Contains 1 IQ domain


uniprot_information_type: SwissProt: Q63HR2
uniprot_information:
Contains 1 C2 tensin-type domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 phosphatase tensin-type domain &  Contains 1 SH2 domain


uniprot_information_type:
SwissProt: Q9H2S9 # The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members &  C-terminal zinc fingers mediate homodimerization# Belongs to the Ikaros C2H2-type zinc-finger protein family &  Contains 6 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q9H2S9 # The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members &  C-terminal zinc fingers mediate homodimerization# Belongs to the Ikaros C2H2-type zinc-finger protein family &  Contains 6 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: P21860 # The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins# Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P21860 # The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins# Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q15742 # The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization &  The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression# Belongs to the NAB family

uniprot_information:
SwissProt: Q15742 # The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization &  The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression# Belongs to the NAB family


uniprot_information_type: SwissProt: Q07954
uniprot_information:
Belongs to the LDLR family &  Contains 22 EGF-like domains &  Contains 31 LDL-receptor class A domains &  Contains 34 LDL-receptor class B repeats


uniprot_information_type: SwissProt: P56192
uniprot_information:
Belongs to the class-I aminoacyl-tRNA synthetase family &  Contains 1 GST C-terminal domain &  Contains 1 WHEP-TRS domain


uniprot_information_type:
SwissProt: Q12840 # Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles# Belongs to the kinesin-like protein family. Kinesin subfamily &  Contains 1 kinesin-motor domain

uniprot_information:
SwissProt: Q12840 # Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles# Belongs to the kinesin-like protein family. Kinesin subfamily &  Contains 1 kinesin-motor domain


uniprot_information_type:
SwissProt: Q00987 # Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73 and E2F1. Region II contains most of a central acidic region required for interaction with ribosomal protein L5 and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc interacts specifically with RNA whether or not zinc is present and mediates the heterooligomerization with MDM4. It is also essential for its ubiquitin ligase E3 activity toward p53 and itself# Belongs to the MDM2/MDM4 family &  Contains 1 RanBP2-type zinc finger &  Contains 1 RING-type zinc finger &  Contains 1 SWIB domain

uniprot_information:
SwissProt: Q00987 # Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73 and E2F1. Region II contains most of a central acidic region required for interaction with ribosomal protein L5 and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc interacts specifically with RNA whether or not zinc is present and mediates the heterooligomerization with MDM4. It is also essential for its ubiquitin ligase E3 activity toward p53 and itself# Belongs to the MDM2/MDM4 family &  Contains 1 RanBP2-type zinc finger &  Contains 1 RING-type zinc finger &  Contains 1 SWIB domain


