# uniprot

uniprot_information_type:
SwissProt: Q8IUH5 # The DHHC domain is required for palmitoyltransferase activity# Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily &  Contains 5 ANK repeats &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q8IUH5 # The DHHC domain is required for palmitoyltransferase activity# Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily &  Contains 5 ANK repeats &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: P21579 # The first C2 domain mediates Ca(2+)-dependent phospholipid binding &  The second C2 domain mediates interaction with SV2A and STN2 (By similarity)# Belongs to the synaptotagmin family &  Contains 2 C2 domains

uniprot_information:
SwissProt: P21579 # The first C2 domain mediates Ca(2+)-dependent phospholipid binding &  The second C2 domain mediates interaction with SV2A and STN2 (By similarity)# Belongs to the synaptotagmin family &  Contains 2 C2 domains


uniprot_information_type:
SwissProt: O14508 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes# Contains 1 SH2 domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: O14508 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes# Contains 1 SH2 domain &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: P78560 # Contains a death domain involved in the binding of RIP protein &  The CARD domain mediates the interaction with caspase-2# Contains 1 CARD domain &  Contains 1 death domain

uniprot_information:
SwissProt: P78560 # Contains a death domain involved in the binding of RIP protein &  The CARD domain mediates the interaction with caspase-2# Contains 1 CARD domain &  Contains 1 death domain


uniprot_information_type:
SwissProt: P42166 # The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1 &  The C-terminal domain forms a four-stranded coiled coil (By similarity)# Belongs to the LEM family &  Contains 1 LEM domain &  Contains 1 LEM-like domain

uniprot_information:
SwissProt: P42166 # The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1 &  The C-terminal domain forms a four-stranded coiled coil (By similarity)# Belongs to the LEM family &  Contains 1 LEM domain &  Contains 1 LEM-like domain


uniprot_information_type:
P42167 # Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1# Belongs to the LEM family &  Contains 1 LEM domain &  Contains 1 LEM-like domain

uniprot_information:
P42167 # Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1# Belongs to the LEM family &  Contains 1 LEM domain &  Contains 1 LEM-like domain


uniprot_information_type:
SwissProt: O14727 # The CARD domain mediates interaction with APIP# Contains 1 CARD domain &  Contains 1 NB-ARC domain &  Contains 13 WD repeats

uniprot_information:
SwissProt: O14727 # The CARD domain mediates interaction with APIP# Contains 1 CARD domain &  Contains 1 NB-ARC domain &  Contains 13 WD repeats


uniprot_information_type: SwissProt: Q6P3W7
uniprot_information:
Belongs to the protein kinase superfamily &  Contains 1 HEAT repeat &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8WWQ8 # Recognizes phosphatidyl serine via its epidermal growth factor-like domains# Contains 17 EGF-like domains &  Contains 7 FAS1 domains &  Contains 2 laminin EGF-like domains &  Contains 1 Link domain

uniprot_information:
SwissProt: Q8WWQ8 # Recognizes phosphatidyl serine via its epidermal growth factor-like domains# Contains 17 EGF-like domains &  Contains 7 FAS1 domains &  Contains 2 laminin EGF-like domains &  Contains 1 Link domain


uniprot_information_type:
SwissProt: Q16881 # The N-terminal glutaredoxin domain found in isoform 1 does not contain the C-P-Y-C redox-active motif normally found in glutaredoxins and has been found to be inactive in classical glutaredoxin assays# Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family &  Contains 1 glutaredoxin domain

uniprot_information:
SwissProt: Q16881 # The N-terminal glutaredoxin domain found in isoform 1 does not contain the C-P-Y-C redox-active motif normally found in glutaredoxins and has been found to be inactive in classical glutaredoxin assays# Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family &  Contains 1 glutaredoxin domain


uniprot_information_type:
SwissProt: Q9BVA6 # The fido domain mediates the adenylyltransferase activity# Belongs to the fic family &  Contains 1 fido domain &  Contains 2 TPR repeats

uniprot_information:
SwissProt: Q9BVA6 # The fido domain mediates the adenylyltransferase activity# Belongs to the fic family &  Contains 1 fido domain &  Contains 2 TPR repeats


uniprot_information_type:
SwissProt: Q06124 # The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing proteins relieves this auto-inhibition, possibly by inducing a conformational change in the enzyme# Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily &  Contains 2 SH2 domains &  Contains 1 tyrosine-protein phosphatase domain

uniprot_information:
SwissProt: Q06124 # The SH2 domains repress phosphatase activity. Binding of these domains to phosphotyrosine-containing proteins relieves this auto-inhibition, possibly by inducing a conformational change in the enzyme# Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily &  Contains 2 SH2 domains &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: Q9ULQ1 # Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily

uniprot_information:
SwissProt: Q9ULQ1 # Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily


uniprot_information_type:
SwissProt: Q9NZU7 # EF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium cooperatively and EF-2 binds neither calcium nor magnesium# Contains 4 EF-hand domains

uniprot_information:
SwissProt: Q9NZU7 # EF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium cooperatively and EF-2 binds neither calcium nor magnesium# Contains 4 EF-hand domains


uniprot_information_type: SwissProt: Q9UPS6
uniprot_information:
Contains 1 post-SET domain &  Contains 1 RRM (RNA recognition motif) domain &  Contains 1 SET domain


uniprot_information_type:
SwissProt: O75146 # Binds F-actin via the talin-like I/LWEQ domain# Belongs to the SLA2 family &  Contains 1 ENTH (epsin N-terminal homology) domain &  Contains 1 I/LWEQ domain

uniprot_information:
SwissProt: O75146 # Binds F-actin via the talin-like I/LWEQ domain# Belongs to the SLA2 family &  Contains 1 ENTH (epsin N-terminal homology) domain &  Contains 1 I/LWEQ domain


uniprot_information_type:
SwissProt: Q9NQR1 # Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity# Belongs to the histone-lysine methyltransferase family. PR/SET subfamily &  Contains 1 SET domain

uniprot_information:
SwissProt: Q9NQR1 # Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity# Belongs to the histone-lysine methyltransferase family. PR/SET subfamily &  Contains 1 SET domain


uniprot_information_type:
SwissProt: Q9ULW2 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain

uniprot_information:
SwissProt: Q9ULW2 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain


uniprot_information_type:
SwissProt: Q9ULZ9 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: Q9ULZ9 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type: SwissProt: O75385
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q96L91
uniprot_information:
Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 HSA domain &  Contains 1 Myb-like domain


uniprot_information_type: SwissProt: Q14587
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 24 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q9NZJ4 # The ubiquitin-like domain mediates interaction with the proteasome &  The J domain is functional and is shown to stimulate E.coli dnaK ATPase activity# Contains 1 HEPN domain &  Contains 1 J domain &  Contains 1 ubiquitin-like domain

uniprot_information:
SwissProt: Q9NZJ4 # The ubiquitin-like domain mediates interaction with the proteasome &  The J domain is functional and is shown to stimulate E.coli dnaK ATPase activity# Contains 1 HEPN domain &  Contains 1 J domain &  Contains 1 ubiquitin-like domain


uniprot_information_type: SwissProt: P36888
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O15075
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Contains 2 doublecortin domains &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9UBN4 # The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation &  The calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) domain (695-724) is sufficient for the interaction with SESTD1 &  The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5# Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily &  Contains 2 ANK repeats

uniprot_information:
SwissProt: Q9UBN4 # The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation &  The calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) domain (695-724) is sufficient for the interaction with SESTD1 &  The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5# Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily &  Contains 2 ANK repeats


uniprot_information_type:
SwissProt: P28223 # The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4# Belongs to the G-protein coupled receptor 1 family

uniprot_information:
SwissProt: P28223 # The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4# Belongs to the G-protein coupled receptor 1 family


uniprot_information_type:
SwissProt: O00505 # Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import &  The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity) &  The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)# Belongs to the importin alpha family &  Contains 10 ARM repeats &  Contains 1 IBB domain

uniprot_information:
SwissProt: O00505 # Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import &  The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity) &  The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)# Belongs to the importin alpha family &  Contains 10 ARM repeats &  Contains 1 IBB domain


uniprot_information_type:
SwissProt: Q9NSV4 # DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction (By similarity)# Belongs to the formin homology family. Diaphanous subfamily &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain

uniprot_information:
SwissProt: Q9NSV4 # DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction (By similarity)# Belongs to the formin homology family. Diaphanous subfamily &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


uniprot_information_type:
SwissProt: Q9UI36 # The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain# Belongs to the DACH/dachshund family

uniprot_information:
SwissProt: Q9UI36 # The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain# Belongs to the DACH/dachshund family


uniprot_information_type: SwissProt: O75592
uniprot_information:
Belongs to the highwire family &  Contains 1 B box-type zinc finger &  Contains 1 DOC domain &  Contains 1 filamin repeat &  Contains 5 RCC1 repeats &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: P24530
uniprot_information:
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily


uniprot_information_type:
SwissProt: O43597 # The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles# Belongs to the sprouty family &  Contains 1 SPR (sprouty) domain

uniprot_information:
SwissProt: O43597 # The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles# Belongs to the sprouty family &  Contains 1 SPR (sprouty) domain


uniprot_information_type:
SwissProt: Q9BZ29 # The DHR-2 domain is necessary and sufficient for the GEF activity# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q9BZ29 # The DHR-2 domain is necessary and sufficient for the GEF activity# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: P02462 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain

uniprot_information:
SwissProt: P02462 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain


uniprot_information_type:
SwissProt: Q9UPY6 # Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain# Belongs to the SCAR/WAVE family &  Contains 1 WH2 domain

uniprot_information:
SwissProt: Q9UPY6 # Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain# Belongs to the SCAR/WAVE family &  Contains 1 WH2 domain


uniprot_information_type:
SwissProt: P52945 # The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter (By similarity) &  The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein-protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y) (By similarity)# Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily &  Contains 1 homeobox DNA-binding domain

uniprot_information:
SwissProt: P52945 # The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter (By similarity) &  The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein-protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y) (By similarity)# Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily &  Contains 1 homeobox DNA-binding domain


uniprot_information_type:
SwissProt: P20292 # The C-terminal part after residue 140 is mostly unstructured# Belongs to the MAPEG family

uniprot_information:
SwissProt: P20292 # The C-terminal part after residue 140 is mostly unstructured# Belongs to the MAPEG family


uniprot_information_type:
SwissProt: Q9UEF7 # Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 239, and the second one lacks the essential Glu active site residue at position 872# Belongs to the glycosyl hydrolase 1 family. Klotho subfamily

uniprot_information:
SwissProt: Q9UEF7 # Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 239, and the second one lacks the essential Glu active site residue at position 872# Belongs to the glycosyl hydrolase 1 family. Klotho subfamily


uniprot_information_type:
SwissProt: Q8NFP9 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer (By similarity)# Belongs to the WD repeat neurobeachin family &  Contains 1 BEACH domain &  Contains 5 WD repeats

uniprot_information:
SwissProt: Q8NFP9 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer (By similarity)# Belongs to the WD repeat neurobeachin family &  Contains 1 BEACH domain &  Contains 5 WD repeats


uniprot_information_type:
SwissProt: O75554 # The WW domain recognizes the proline, glycine and methionine-rich (PGM) motif present in the splicing factors, as well as the Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (By similarity)# Contains 1 matrin-type zinc finger &  Contains 2 WW domains

uniprot_information:
SwissProt: O75554 # The WW domain recognizes the proline, glycine and methionine-rich (PGM) motif present in the splicing factors, as well as the Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (By similarity)# Contains 1 matrin-type zinc finger &  Contains 2 WW domains


uniprot_information_type:
SwissProt: Q9UKA4 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Belongs to the AKAP110 family

uniprot_information:
SwissProt: Q9UKA4 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Belongs to the AKAP110 family


uniprot_information_type:
SwissProt: P06400 # The Pocket domain binds to the threonine-phosphorylated domain C, thereby preventing interaction with heterodimeric E2F/DP transcription factor complexes# Belongs to the retinoblastoma protein (RB) family

uniprot_information:
SwissProt: P06400 # The Pocket domain binds to the threonine-phosphorylated domain C, thereby preventing interaction with heterodimeric E2F/DP transcription factor complexes# Belongs to the retinoblastoma protein (RB) family


uniprot_information_type:
SwissProt: O60858 # The RING-type zinc finger is required for auto-polyubiquitination &  The C-terminal domain transmembrane domain is indispensable for the localization to the ER# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: O60858 # The RING-type zinc finger is required for auto-polyubiquitination &  The C-terminal domain transmembrane domain is indispensable for the localization to the ER# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q6UX06 # The olfactomedin-like domain is involved in the interaction with cadherin# Contains 1 olfactomedin-like domain

uniprot_information:
SwissProt: Q6UX06 # The olfactomedin-like domain is involved in the interaction with cadherin# Contains 1 olfactomedin-like domain


uniprot_information_type: SwissProt: Q8WWI1
uniprot_information:
Contains 1 CH (calponin-homology) domain &  Contains 1 LIM zinc-binding domain &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: Q13217 # The J domain mediates interaction with HSPA8# Contains 1 J domain &  Contains 9 TPR repeats

uniprot_information:
SwissProt: Q13217 # The J domain mediates interaction with HSPA8# Contains 1 J domain &  Contains 9 TPR repeats


uniprot_information_type:
SwissProt: P10114 # The effector domain mediates the interaction with RUNDC3A (By similarity)# Belongs to the small GTPase superfamily. Ras family

uniprot_information:
SwissProt: P10114 # The effector domain mediates the interaction with RUNDC3A (By similarity)# Belongs to the small GTPase superfamily. Ras family


uniprot_information_type: SwissProt: O00410
uniprot_information:
Belongs to the importin beta family &  Contains 6 HEAT repeats &  Contains 1 importin N-terminal domain


uniprot_information_type:
SwissProt: O95965 # Contains ten tandem EGF-like repeats strikingly similar to those found in the cysteine rich 'stalk-like' structure of integrin beta-subunits #

uniprot_information:
SwissProt: O95965 # Contains ten tandem EGF-like repeats strikingly similar to those found in the cysteine rich 'stalk-like' structure of integrin beta-subunits #


uniprot_information_type:
SwissProt: P08572 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain

uniprot_information:
SwissProt: P08572 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain


uniprot_information_type:
SwissProt: O15068 # The CRAL-TRIO domain is involved in interaction with inositol phospholipids &  The DH domain is involved in interaction with CCPG1 (By similarity)# Belongs to the MCF2 family &  Contains 1 CRAL-TRIO domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 SH3 domain &  Contains 1 spectrin repeat

uniprot_information:
SwissProt: O15068 # The CRAL-TRIO domain is involved in interaction with inositol phospholipids &  The DH domain is involved in interaction with CCPG1 (By similarity)# Belongs to the MCF2 family &  Contains 1 CRAL-TRIO domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 SH3 domain &  Contains 1 spectrin repeat


uniprot_information_type: SwissProt: Q99973
uniprot_information:
Contains 1 NACHT domain &  Contains 4 TEP1 N-terminal repeats &  Contains 1 TROVE domain &  Contains 21 WD repeats


uniprot_information_type: SwissProt: Q9HCK8
uniprot_information:
Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily &  Contains 2 chromo domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: O43281 # Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains &  The SH3-binding sites that bind to the SRC SH3 domain are required for interaction with CRK and are implicated in promotion of serum response element (SRE) activation. The SH3 domain interacts with focal adhesion kinase 1# Belongs to the CAS family &  Contains 1 SH3 domain

uniprot_information:
SwissProt: O43281 # Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains &  The SH3-binding sites that bind to the SRC SH3 domain are required for interaction with CRK and are implicated in promotion of serum response element (SRE) activation. The SH3 domain interacts with focal adhesion kinase 1# Belongs to the CAS family &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P13533 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: P13533 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type:
SwissProt: P12883 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: P12883 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type:
SwissProt: Q9BY43 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity)# Belongs to the SNF7 family

uniprot_information:
SwissProt: Q9BY43 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity)# Belongs to the SNF7 family


uniprot_information_type: SwissProt: Q9NRL2
uniprot_information:
Belongs to the WAL family &  Contains 1 bromo domain &  Contains 1 DDT domain &  Contains 1 PHD-type zinc finger &  Contains 1 WAC domain


uniprot_information_type:
SwissProt: Q00532 # The [NKR]KIAxRE motif seems to be a cyclin-binding region# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q00532 # The [NKR]KIAxRE motif seems to be a cyclin-binding region# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9C026 # The coiled coil domain mediates the interaction with the N-terminal t-SNARE domain of SNAP25 (By similarity)# Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 B30.2/SPRY domain &  Contains 1 COS domain &  Contains 1 fibronectin type-III domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q9C026 # The coiled coil domain mediates the interaction with the N-terminal t-SNARE domain of SNAP25 (By similarity)# Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 B30.2/SPRY domain &  Contains 1 COS domain &  Contains 1 fibronectin type-III domain &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q14112
uniprot_information:
Contains 5 EGF-like domains &  Contains 5 LDL-receptor class B repeats &  Contains 1 NIDO domain &  Contains 1 nidogen G2 beta-barrel domain &  Contains 2 thyroglobulin type-1 domains


uniprot_information_type:
SwissProt: Q96AC1 # The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain# Belongs to the kindlin family &  Contains 1 FERM domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q96AC1 # The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain# Belongs to the kindlin family &  Contains 1 FERM domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q9Y5J7 # The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable)# Belongs to the small Tim family

uniprot_information:
SwissProt: Q9Y5J7 # The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (Probable)# Belongs to the small Tim family


uniprot_information_type:
SwissProt: Q92731 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: Q92731 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type: SwissProt: P11277
uniprot_information:
Belongs to the spectrin family &  Contains 2 CH (calponin-homology) domains &  Contains 17 spectrin repeats


uniprot_information_type:
SwissProt: O43506 # A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding &  The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: O43506 # A tripeptide motif (VGE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding &  The cysteine-rich domain encodes putative cell-fusion peptides, which could be involved in sperm-egg fusion &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain


uniprot_information_type:
SwissProt: Q92784 # The PHD-type zinc fingers mediate the binding to acetylated histones# Belongs to the requiem/DPF family &  Contains 1 C2H2-type zinc finger &  Contains 2 PHD-type zinc fingers

uniprot_information:
SwissProt: Q92784 # The PHD-type zinc fingers mediate the binding to acetylated histones# Belongs to the requiem/DPF family &  Contains 1 C2H2-type zinc finger &  Contains 2 PHD-type zinc fingers


uniprot_information_type:
SwissProt: Q14767 # Associates covalently with small latent TGF-beta complex via Repeat B and Repeat C (By similarity)# Belongs to the LTBP family &  Contains 20 EGF-like domains &  Contains 4 TB (TGF-beta binding) domains

uniprot_information:
SwissProt: Q14767 # Associates covalently with small latent TGF-beta complex via Repeat B and Repeat C (By similarity)# Belongs to the LTBP family &  Contains 20 EGF-like domains &  Contains 4 TB (TGF-beta binding) domains


uniprot_information_type:
SwissProt: P49763 # Isoform PlGF-2 contains a basic insert which acts as a cell retention signal# Belongs to the PDGF/VEGF growth factor family

uniprot_information:
SwissProt: P49763 # Isoform PlGF-2 contains a basic insert which acts as a cell retention signal# Belongs to the PDGF/VEGF growth factor family


uniprot_information_type:
SwissProt: Q8TD19 # Dimerizes through its coiled-coil domain# Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily &  Contains 1 protein kinase domain &  Contains 6 RCC1 repeats

uniprot_information:
SwissProt: Q8TD19 # Dimerizes through its coiled-coil domain# Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily &  Contains 1 protein kinase domain &  Contains 6 RCC1 repeats


uniprot_information_type: SwissProt: Q9UBV2
uniprot_information:
Belongs to the sel-1 family &  Contains 1 fibronectin type-II domain &  Contains 11 Sel1-like repeats


uniprot_information_type:
SwissProt: Q96BY2 # The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction# Belongs to the PNMA family

uniprot_information:
SwissProt: Q96BY2 # The BH3-like domain is required for association with BAX and for mediating apoptosis. The three BH domains (BH1, BH2, and BH3) of BAX are all required for mediating protein-protein interaction# Belongs to the PNMA family


uniprot_information_type: SwissProt: Q9GZR7
uniprot_information:
Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: P01009 # The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable# Belongs to the serpin family

uniprot_information:
SwissProt: P01009 # The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable# Belongs to the serpin family


uniprot_information_type: SwissProt: Q9UPY3
uniprot_information:
Belongs to the helicase family. Dicer subfamily &  Contains 1 Dicer dsRNA-binding fold domain &  Contains 1 DRBM (double-stranded RNA-binding) domain &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 PAZ domain &  Contains 2 RNase III domains


uniprot_information_type:
SwissProt: Q96KQ4 # The ankyrin repeats and the SH3 domain are required for specific interactions with TP53# Belongs to the ASPP family &  Contains 2 ANK repeats &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q96KQ4 # The ankyrin repeats and the SH3 domain are required for specific interactions with TP53# Belongs to the ASPP family &  Contains 2 ANK repeats &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P31749 # Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane &  The AGC-kinase C-terminal mediates interaction with THEM4# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P31749 # Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane &  The AGC-kinase C-terminal mediates interaction with THEM4# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P10153 # The N-terminal region is necessary for mediating chemotactic activity# Belongs to the pancreatic ribonuclease family

uniprot_information:
SwissProt: P10153 # The N-terminal region is necessary for mediating chemotactic activity# Belongs to the pancreatic ribonuclease family


uniprot_information_type:
SwissProt: P50281 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: P50281 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: Q92843 # The BH4 motif seems to be involved in the anti-apoptotic function &  The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2# Belongs to the Bcl-2 family

uniprot_information:
SwissProt: Q92843 # The BH4 motif seems to be involved in the anti-apoptotic function &  The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2# Belongs to the Bcl-2 family


uniprot_information_type:
SwissProt: Q86U42 # The RRM domain is essential for specific adenine bases recognition in the poly(A) tail but not sufficient for poly(A) binding (By similarity)# Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q86U42 # The RRM domain is essential for specific adenine bases recognition in the poly(A) tail but not sufficient for poly(A) binding (By similarity)# Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type: SwissProt: Q96EP0
uniprot_information:
Contains 2 IBR-type zinc fingers &  Contains 3 RanBP2-type zinc fingers &  Contains 1 RING-type zinc finger &  Contains 1 UBA domain


uniprot_information_type:
SwissProt: Q14934 # Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors (By similarity)# Contains 1 IPT/TIG domain &  Contains 1 RHD (Rel-like) domain

uniprot_information:
SwissProt: Q14934 # Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors (By similarity)# Contains 1 IPT/TIG domain &  Contains 1 RHD (Rel-like) domain


uniprot_information_type:
SwissProt: Q13023 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Contains 2 spectrin repeats

uniprot_information:
SwissProt: Q13023 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Contains 2 spectrin repeats


uniprot_information_type:
SwissProt: P61011 # Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence# Belongs to the GTP-binding SRP family

uniprot_information:
SwissProt: P61011 # Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence# Belongs to the GTP-binding SRP family


uniprot_information_type:
SwissProt: Q9NYF0 # The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins (By similarity)# Belongs to the dapper family

uniprot_information:
SwissProt: Q9NYF0 # The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins (By similarity)# Belongs to the dapper family


uniprot_information_type:
SwissProt: Q9Y4D1 # The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus# Belongs to the formin homology family &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain

uniprot_information:
SwissProt: Q9Y4D1 # The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus# Belongs to the formin homology family &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


uniprot_information_type:
SwissProt: P24723 # The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P24723 # The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q16665 # Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 2 PAS (PER-ARNT-SIM) domains

uniprot_information:
SwissProt: Q16665 # Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 2 PAS (PER-ARNT-SIM) domains


uniprot_information_type:
SwissProt: Q8WXH0 # The KASH domain mediates the nuclear envelope targeting# Belongs to the nesprin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 1 KASH domain &  Contains 13 LRR (leucine-rich) repeats &  Contains 9 spectrin repeats

uniprot_information:
SwissProt: Q8WXH0 # The KASH domain mediates the nuclear envelope targeting# Belongs to the nesprin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 1 KASH domain &  Contains 13 LRR (leucine-rich) repeats &  Contains 9 spectrin repeats


uniprot_information_type:
SwissProt: P11586 # This trifunctional enzyme consists of two major domains: an N-terminal part containing the methylene-THF dehydrogenase and cyclohydrolase activities and a larger C-terminal part containing formyl-THF synthetase activity# In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family &  In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family

uniprot_information:
SwissProt: P11586 # This trifunctional enzyme consists of two major domains: an N-terminal part containing the methylene-THF dehydrogenase and cyclohydrolase activities and a larger C-terminal part containing formyl-THF synthetase activity# In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family &  In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family


uniprot_information_type:
SwissProt: P24588 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Contains 1 AKAP domain

uniprot_information:
SwissProt: P24588 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Contains 1 AKAP domain


uniprot_information_type: SwissProt: Q9NQX3
uniprot_information:
In the N-terminal section; belongs to the moaB/mog family &  In the C-terminal section; belongs to the moeA family


uniprot_information_type:
SwissProt: Q8N3R9 # The L27 domain 1 functions in targeting to the tight junctions by binding to INADL (By similarity) &  The PDZ domain binds to the C-terminus of SC6A1 (By similarity)# Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 2 L27 domains &  Contains 1 PDZ (DHR) domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q8N3R9 # The L27 domain 1 functions in targeting to the tight junctions by binding to INADL (By similarity) &  The PDZ domain binds to the C-terminus of SC6A1 (By similarity)# Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 2 L27 domains &  Contains 1 PDZ (DHR) domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P49768 # The PAL motif is required for normal active site conformation# Belongs to the peptidase A22A family

uniprot_information:
SwissProt: P49768 # The PAL motif is required for normal active site conformation# Belongs to the peptidase A22A family


uniprot_information_type: SwissProt: Q9UPI3
uniprot_information:
Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family


uniprot_information_type: SwissProt: O43708
uniprot_information:
Belongs to the GST superfamily. Zeta family &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain


uniprot_information_type: SwissProt: P16473
uniprot_information:
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily &  Contains 6 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: P01011 # The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable# Belongs to the serpin family

uniprot_information:
SwissProt: P01011 # The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable# Belongs to the serpin family


uniprot_information_type: SwissProt: P30411
uniprot_information:
Belongs to the G-protein coupled receptor 1 family. Bradikinin receptor subfamily. BDKRB2 sub-subfamily


uniprot_information_type: SwissProt: P46663
uniprot_information:
Belongs to the G-protein coupled receptor 1 family. Bradikinin receptor subfamily. BDKRB1 sub-subfamily


uniprot_information_type:
SwissProt: Q14204 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function# Belongs to the dynein heavy chain family

uniprot_information:
SwissProt: Q14204 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function# Belongs to the dynein heavy chain family


uniprot_information_type:
SwissProt: Q9UKL0 # The SANT domains may bridge the nucleosomal substrates and the demethylase KDM1A# Belongs to the CoREST family &  Contains 1 ELM2 domain &  Contains 2 SANT domains

uniprot_information:
SwissProt: Q9UKL0 # The SANT domains may bridge the nucleosomal substrates and the demethylase KDM1A# Belongs to the CoREST family &  Contains 1 ELM2 domain &  Contains 2 SANT domains


uniprot_information_type:
SwissProt: Q13114 # The MATH/TRAF domain binds to receptor cytoplasmic domains# Belongs to the TNF receptor-associated factor family. A subfamily &  Contains 1 MATH domain &  Contains 1 RING-type zinc finger &  Contains 2 TRAF-type zinc fingers

uniprot_information:
SwissProt: Q13114 # The MATH/TRAF domain binds to receptor cytoplasmic domains# Belongs to the TNF receptor-associated factor family. A subfamily &  Contains 1 MATH domain &  Contains 1 RING-type zinc finger &  Contains 2 TRAF-type zinc fingers


uniprot_information_type:
SwissProt: Q27J81 # The WH2 domain acts as the DAD (diaphanous autoregulatory) domain and binds to actin monomers (By similarity) &  Regulated by autoinhibition due to intramolecular GBD-DAD binding (By similarity) &  The severing activity is dependent on covalent attachment of the FH2 domain to the C-terminus (By similarity)# Belongs to the formin homology family &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain &  Contains 1 WH2 domain

uniprot_information:
SwissProt: Q27J81 # The WH2 domain acts as the DAD (diaphanous autoregulatory) domain and binds to actin monomers (By similarity) &  Regulated by autoinhibition due to intramolecular GBD-DAD binding (By similarity) &  The severing activity is dependent on covalent attachment of the FH2 domain to the C-terminus (By similarity)# Belongs to the formin homology family &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain &  Contains 1 WH2 domain


uniprot_information_type:
SwissProt: Q13330 # Isoform Short contains a Leu-Arg-Ile-Leu-Leu motif (ER binding motif)# Contains 1 BAH domain &  Contains 1 ELM2 domain &  Contains 1 GATA-type zinc finger &  Contains 1 SANT domain

uniprot_information:
SwissProt: Q13330 # Isoform Short contains a Leu-Arg-Ile-Leu-Leu motif (ER binding motif)# Contains 1 BAH domain &  Contains 1 ELM2 domain &  Contains 1 GATA-type zinc finger &  Contains 1 SANT domain


uniprot_information_type: SwissProt: P28472
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily


uniprot_information_type: SwissProt: O95714
uniprot_information:
Contains 1 cytochrome b5 heme-binding domain &  Contains 1 DOC domain &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 1 MIB/HERC2 domain &  Contains 19 RCC1 repeats &  Contains 6 WD repeats &  Contains 1 ZZ-type zinc finger


uniprot_information_type:
SwissProt: Q07157 # The second PDZ domain mediates interaction with GJA12 (By similarity)# Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 3 PDZ (DHR) domains &  Contains 1 SH3 domain &  Contains 1 ZU5 domain

uniprot_information:
SwissProt: Q07157 # The second PDZ domain mediates interaction with GJA12 (By similarity)# Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 3 PDZ (DHR) domains &  Contains 1 SH3 domain &  Contains 1 ZU5 domain


uniprot_information_type:
SwissProt: A8MQT2 # Extended rod-like protein with coiled-coil domains# Belongs to the GOLGA8 family

uniprot_information:
SwissProt: A8MQT2 # Extended rod-like protein with coiled-coil domains# Belongs to the GOLGA8 family


uniprot_information_type:
SwissProt: O95267 # The phorbol-ester/DAG-type zinc finger is the principal mediator of the targeting to membranes and is required for functional activation through DAG-binding# Belongs to the RASGRP family &  Contains 2 EF-hand domains &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 Ras-GEF domain

uniprot_information:
SwissProt: O95267 # The phorbol-ester/DAG-type zinc finger is the principal mediator of the targeting to membranes and is required for functional activation through DAG-binding# Belongs to the RASGRP family &  Contains 2 EF-hand domains &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 Ras-GEF domain


uniprot_information_type:
SwissProt: Q96TC7 # The transmembrane region is required for mitochondrial localization# Belongs to the FAM82/RMD family

uniprot_information:
SwissProt: Q96TC7 # The transmembrane region is required for mitochondrial localization# Belongs to the FAM82/RMD family


uniprot_information_type: SwissProt: P29376
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9NRC6
uniprot_information:
Belongs to the spectrin family &  Contains 2 CH (calponin-homology) domains &  Contains 1 PH domain &  Contains 31 spectrin repeats


uniprot_information_type:
SwissProt: Q9H223 # The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity)# Contains 1 EF-hand domain &  Contains 1 EH domain

uniprot_information:
SwissProt: Q9H223 # The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity)# Contains 1 EF-hand domain &  Contains 1 EH domain


uniprot_information_type: SwissProt: Q6IQ55
uniprot_information:
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9NRD8
uniprot_information:
In the N-terminal section; belongs to the peroxidase family &  Contains 3 EF-hand domains &  Contains 1 FAD-binding FR-type domain &  Contains 1 ferric oxidoreductase domain


uniprot_information_type:
SwissProt: P50440 # One chain folds into a compact single domain composed of repeating units, five beta-beta-alpha-beta modules, which surround the central active site# Belongs to the amidinotransferase family

uniprot_information:
SwissProt: P50440 # One chain folds into a compact single domain composed of repeating units, five beta-beta-alpha-beta modules, which surround the central active site# Belongs to the amidinotransferase family


uniprot_information_type:
SwissProt: O14863 # Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc (By similarity)# Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily

uniprot_information:
SwissProt: O14863 # Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc (By similarity)# Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily


uniprot_information_type: SwissProt: Q9UBC0
uniprot_information:
Belongs to the CUT homeobox family &  Contains 1 CUT DNA-binding domain &  Contains 1 homeobox DNA-binding domain


uniprot_information_type:
SwissProt: P46934 # The WW domains mediate interaction with LITAF, RNF11, WBP1, WBP2, TMEPAI, NDFIP1 and PRRG2 (By similarity)# Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 4 WW domains

uniprot_information:
SwissProt: P46934 # The WW domains mediate interaction with LITAF, RNF11, WBP1, WBP2, TMEPAI, NDFIP1 and PRRG2 (By similarity)# Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 4 WW domains


uniprot_information_type:
SwissProt: O14672 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: O14672 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain


uniprot_information_type:
SwissProt: P07355 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats

uniprot_information:
SwissProt: P07355 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats


uniprot_information_type: SwissProt: Q15751
uniprot_information:
Contains 1 B30.2/SPRY domain &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 14 RCC1 repeats &  Contains 11 WD repeats


uniprot_information_type: SwissProt: P23284
uniprot_information:
Belongs to the cyclophilin-type PPIase family. PPIase B subfamily &  Contains 1 PPIase cyclophilin-type domain


uniprot_information_type: SwissProt: B2RTY4
uniprot_information:
Contains 5 IQ domains &  Contains 2 myosin head-like domains &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 Ras-associating domain &  Contains 1 Rho-GAP domain


uniprot_information_type:
SwissProt: Q9Y3Q4 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel HCN family &  Contains 1 cyclic nucleotide-binding domain

uniprot_information:
SwissProt: Q9Y3Q4 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel HCN family &  Contains 1 cyclic nucleotide-binding domain


uniprot_information_type:
SwissProt: Q9Y639 # Some isoforms lack the first Ig-like domain which may confer homophilic adhesion activity. However, they can bind and activate FGFR1 (By similarity)# Contains 3 Ig-like (immunoglobulin-like) domains

uniprot_information:
SwissProt: Q9Y639 # Some isoforms lack the first Ig-like domain which may confer homophilic adhesion activity. However, they can bind and activate FGFR1 (By similarity)# Contains 3 Ig-like (immunoglobulin-like) domains


uniprot_information_type: SwissProt: P43378
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily &  Contains 1 CRAL-TRIO domain &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type: SwissProt: P32297
uniprot_information:
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-3/CHRNA3 sub-subfamily


uniprot_information_type: SwissProt: P30926
uniprot_information:
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-4/CHRNB4 sub-subfamily


uniprot_information_type:
SwissProt: Q9UKP4 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 8 TSP type-1 domains

uniprot_information:
SwissProt: Q9UKP4 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 8 TSP type-1 domains


uniprot_information_type:
SwissProt: Q13972 # The DH (DBL-homology) domain mediates interaction with RASGRF2# Contains 1 DH (DBL-homology) domain &  Contains 1 IQ domain &  Contains 1 N-terminal Ras-GEF domain &  Contains 2 PH domains &  Contains 1 Ras-GEF domain

uniprot_information:
SwissProt: Q13972 # The DH (DBL-homology) domain mediates interaction with RASGRF2# Contains 1 DH (DBL-homology) domain &  Contains 1 IQ domain &  Contains 1 N-terminal Ras-GEF domain &  Contains 2 PH domains &  Contains 1 Ras-GEF domain


uniprot_information_type:
SwissProt: Q9BZB8 # The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA (By similarity)# Belongs to the RRM CPEB family &  Contains 2 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: Q9BZB8 # The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA (By similarity)# Belongs to the RRM CPEB family &  Contains 2 RRM (RNA recognition motif) domains


uniprot_information_type:
SwissProt: Q9NSB8 # The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3# Belongs to the Homer family &  Contains 1 WH1 domain

uniprot_information:
SwissProt: Q9NSB8 # The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3# Belongs to the Homer family &  Contains 1 WH1 domain


uniprot_information_type:
SwissProt: P15144 # Amino acids 260-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/human chimeric studies) and more specifically amino acids 288-295 (mutagenesis studies)# Belongs to the peptidase M1 family

uniprot_information:
SwissProt: P15144 # Amino acids 260-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/human chimeric studies) and more specifically amino acids 288-295 (mutagenesis studies)# Belongs to the peptidase M1 family


uniprot_information_type:
SwissProt: P29122 # The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum. Isoform PACE4D lacks the propeptide domain# Belongs to the peptidase S8 family &  Contains 1 homo B/P domain &  Contains 1 PLAC domain

uniprot_information:
SwissProt: P29122 # The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum. Isoform PACE4D lacks the propeptide domain# Belongs to the peptidase S8 family &  Contains 1 homo B/P domain &  Contains 1 PLAC domain


uniprot_information_type: SwissProt: P31644
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub-subfamily


uniprot_information_type: SwissProt: Q99928
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG3 sub-subfamily


uniprot_information_type:
SwissProt: Q99767 # Composed of an N-terminal domain that binds STXBP1, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane# Contains 2 PDZ (DHR) domains &  Contains 1 PID domain

uniprot_information:
SwissProt: Q99767 # Composed of an N-terminal domain that binds STXBP1, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane# Contains 2 PDZ (DHR) domains &  Contains 1 PID domain


uniprot_information_type:
SwissProt: Q9Y2Y9 # The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions# Belongs to the Sp1 C2H2-type zinc-finger protein family &  Contains 3 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q9Y2Y9 # The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions# Belongs to the Sp1 C2H2-type zinc-finger protein family &  Contains 3 C2H2-type zinc fingers


uniprot_information_type: SwissProt: Q15413
uniprot_information:
Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR3 subfamily &  Contains 3 B30.2/SPRY domains &  Contains 1 EF-hand domain &  Contains 5 MIR domains


uniprot_information_type:
SwissProt: O60566 # The D-box targets the protein for rapid degradation by ubiquitin-dependent proteolysis during the transition from mitosis to interphase (Potential) &  The BUB1 N-terminal domain directs kinetochore localization and binding to BUB3# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily &  Contains 1 BUB1 N-terminal domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: O60566 # The D-box targets the protein for rapid degradation by ubiquitin-dependent proteolysis during the transition from mitosis to interphase (Potential) &  The BUB1 N-terminal domain directs kinetochore localization and binding to BUB3# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily &  Contains 1 BUB1 N-terminal domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O43278 # This inhibitor contains two inhibitory domains# Contains 2 BPTI/Kunitz inhibitor domains &  Contains 1 LDL-receptor class A domain &  Contains 1 MANSC domain

uniprot_information:
SwissProt: O43278 # This inhibitor contains two inhibitory domains# Contains 2 BPTI/Kunitz inhibitor domains &  Contains 1 LDL-receptor class A domain &  Contains 1 MANSC domain


uniprot_information_type:
SwissProt: Q9BXS6 # The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination# Belongs to the NUSAP family

uniprot_information:
SwissProt: Q9BXS6 # The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination# Belongs to the NUSAP family


uniprot_information_type:
SwissProt: Q8IWI9 # Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 T-box DNA-binding domain

uniprot_information:
SwissProt: Q8IWI9 # Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 T-box DNA-binding domain


uniprot_information_type:
SwissProt: P78559 # The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules# Belongs to the MAP1 family

uniprot_information:
SwissProt: P78559 # The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules# Belongs to the MAP1 family


uniprot_information_type: SwissProt: P61769
uniprot_information:
Belongs to the beta-2-microglobulin family &  Contains 1 Ig-like C1-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: P40818 # The MIT domain is required for endosomal localization, CHMP1B-binding, maintenance of ESCRT-0 stability and EGFR degradation &  The rhodanese domain is sufficent for RNF41-binding (By similarity)# Belongs to the peptidase C19 family &  Contains 1 MIT domain &  Contains 1 rhodanese domain

uniprot_information:
SwissProt: P40818 # The MIT domain is required for endosomal localization, CHMP1B-binding, maintenance of ESCRT-0 stability and EGFR degradation &  The rhodanese domain is sufficent for RNF41-binding (By similarity)# Belongs to the peptidase C19 family &  Contains 1 MIT domain &  Contains 1 rhodanese domain


uniprot_information_type:
SwissProt: Q16659 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q16659 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O43315 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family

uniprot_information:
SwissProt: O43315 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family


uniprot_information_type:
SwissProt: P09493 # The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity# Belongs to the tropomyosin family

uniprot_information:
SwissProt: P09493 # The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity# Belongs to the tropomyosin family


uniprot_information_type:
SwissProt: Q9Y6I4 # Both protease activity and an intact zinc finger are required for H2A monodeubiquitination# Belongs to the peptidase C19 family. USP3 subfamily &  Contains 1 UBP-type zinc finger

uniprot_information:
SwissProt: Q9Y6I4 # Both protease activity and an intact zinc finger are required for H2A monodeubiquitination# Belongs to the peptidase C19 family. USP3 subfamily &  Contains 1 UBP-type zinc finger


uniprot_information_type: SwissProt: Q02750
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P84022 # The MH2 domain is sufficient to carry protein nuclear export# Belongs to the dwarfin/SMAD family &  Contains 1 MH1 (MAD homology 1) domain &  Contains 1 MH2 (MAD homology 2) domain

uniprot_information:
SwissProt: P84022 # The MH2 domain is sufficient to carry protein nuclear export# Belongs to the dwarfin/SMAD family &  Contains 1 MH1 (MAD homology 1) domain &  Contains 1 MH2 (MAD homology 2) domain


uniprot_information_type:
SwissProt: Q13163 # Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the OPR domain. This domain also mediates interactions with SQSTM1 and PARD6A (By similarity)# Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily &  Contains 1 OPR domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q13163 # Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the OPR domain. This domain also mediates interactions with SQSTM1 and PARD6A (By similarity)# Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily &  Contains 1 OPR domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O75925 # The LXXLL motif is a transcriptional coregulator signature &  The SP-RING-type domain is required for promoting EKLF sumoylation (By similarity)# Belongs to the PIAS family &  Contains 1 PINIT domain &  Contains 1 SAP domain &  Contains 1 SP-RING-type zinc finger

uniprot_information:
SwissProt: O75925 # The LXXLL motif is a transcriptional coregulator signature &  The SP-RING-type domain is required for promoting EKLF sumoylation (By similarity)# Belongs to the PIAS family &  Contains 1 PINIT domain &  Contains 1 SAP domain &  Contains 1 SP-RING-type zinc finger


uniprot_information_type:
SwissProt: Q96PH1 # Isoform 3 and isoform 4 of this protein have four functional EF-hand calcium-binding domains. Isoform 1 and isoform 2 have the third EF-hand domain interrupted by an insert# Contains 4 EF-hand domains &  Contains 1 FAD-binding FR-type domain &  Contains 1 ferric oxidoreductase domain

uniprot_information:
SwissProt: Q96PH1 # Isoform 3 and isoform 4 of this protein have four functional EF-hand calcium-binding domains. Isoform 1 and isoform 2 have the third EF-hand domain interrupted by an insert# Contains 4 EF-hand domains &  Contains 1 FAD-binding FR-type domain &  Contains 1 ferric oxidoreductase domain


uniprot_information_type: SwissProt: Q9Y4X5
uniprot_information:
Belongs to the RBR family. Ariadne subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers


uniprot_information_type: SwissProt: Q92859
uniprot_information:
Belongs to the immunoglobulin superfamily. DCC family &  Contains 6 fibronectin type-III domains &  Contains 4 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: P29590 # Interacts with PKM2 via its coiled-coil domain# Contains 2 B box-type zinc fingers &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: P29590 # Interacts with PKM2 via its coiled-coil domain# Contains 2 B box-type zinc fingers &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: P41240
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily &  Contains 1 protein kinase domain &  Contains 1 SH2 domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: O43586 # The coiled domain mediates interaction with PTPN18, PTPN12 and CD2AP. The SH3 domain mediates interaction with WAS and ABL1 (By similarity). The SH3 and coiled-coil domains are necessary for the interaction with MEFV# Contains 1 FCH domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: O43586 # The coiled domain mediates interaction with PTPN18, PTPN12 and CD2AP. The SH3 domain mediates interaction with WAS and ABL1 (By similarity). The SH3 and coiled-coil domains are necessary for the interaction with MEFV# Contains 1 FCH domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P29762 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior (By similarity)# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

uniprot_information:
SwissProt: P29762 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior (By similarity)# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


uniprot_information_type: SwissProt: P30532
uniprot_information:
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily


uniprot_information_type:
SwissProt: Q99963 # An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes (By similarity)# Belongs to the endophilin family &  Contains 1 BAR domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q99963 # An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes (By similarity)# Belongs to the endophilin family &  Contains 1 BAR domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: P82987
uniprot_information:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 PLAC domain &  Contains 10 TSP type-1 domains


uniprot_information_type: SwissProt: Q7Z7L9
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 14 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: Q96L96
uniprot_information:
Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily &  Contains 1 alpha-type protein kinase domain &  Contains 1 Ig-like (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: O60658 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain# Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain

uniprot_information:
SwissProt: O60658 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain# Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain


uniprot_information_type:
SwissProt: Q12802 # Both the DH and PH domains are required for transforming activity# Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger

uniprot_information:
SwissProt: Q12802 # Both the DH and PH domains are required for transforming activity# Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger


uniprot_information_type:
SwissProt: P16112 # Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3# Belongs to the aggrecan/versican proteoglycan family &  Contains 1 C-type lectin domain &  Contains 1 EGF-like domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain &  Contains 4 Link domains &  Contains 1 Sushi (CCP/SCR) domain

uniprot_information:
SwissProt: P16112 # Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3# Belongs to the aggrecan/versican proteoglycan family &  Contains 1 C-type lectin domain &  Contains 1 EGF-like domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain &  Contains 4 Link domains &  Contains 1 Sushi (CCP/SCR) domain


uniprot_information_type:
SwissProt: P46940 # Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of nucleotide-free CDC42 and promotes binding of GTP-bound CDC42. Phosphorylation of Ser-1443 prevents interaction between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free CDC42 on both C1 and C2# Contains 1 CH (calponin-homology) domain &  Contains 4 IQ domains &  Contains 1 Ras-GAP domain &  Contains 1 WW domain

uniprot_information:
SwissProt: P46940 # Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of nucleotide-free CDC42 and promotes binding of GTP-bound CDC42. Phosphorylation of Ser-1443 prevents interaction between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free CDC42 on both C1 and C2# Contains 1 CH (calponin-homology) domain &  Contains 4 IQ domains &  Contains 1 Ras-GAP domain &  Contains 1 WW domain


uniprot_information_type: SwissProt: P54132
uniprot_information:
Belongs to the helicase family. RecQ subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 HRDC domain


uniprot_information_type:
SwissProt: P09958 # Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surface# Belongs to the peptidase S8 family. Furin subfamily &  Contains 1 homo B/P domain

uniprot_information:
SwissProt: P09958 # Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surface# Belongs to the peptidase S8 family. Furin subfamily &  Contains 1 homo B/P domain


uniprot_information_type:
SwissProt: Q9H672 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 7 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q9H672 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 7 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q38SD2
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily &  Contains 4 ANK repeats &  Contains 11 LRR (leucine-rich) repeats &  Contains 1 protein kinase domain &  Contains 1 Roc domain


uniprot_information_type: SwissProt: Q9Y2Y1
uniprot_information:
Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family &  Contains 1 TFIIS-type zinc finger


uniprot_information_type:
SwissProt: Q6PJ21 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the SPSB family &  Contains 1 B30.2/SPRY domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q6PJ21 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the SPSB family &  Contains 1 B30.2/SPRY domain &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: P98161 # The LDL-receptor class A domain is atypical; the potential calcium-binding site is missing# Belongs to the polycystin family &  Contains 1 C-type lectin domain &  Contains 1 GPS domain &  Contains 1 LDL-receptor class A domain &  Contains 6 LRR (leucine-rich) repeats &  Contains 17 PKD domains &  Contains 1 PLAT domain &  Contains 1 REJ domain &  Contains 1 WSC domain

uniprot_information:
SwissProt: P98161 # The LDL-receptor class A domain is atypical; the potential calcium-binding site is missing# Belongs to the polycystin family &  Contains 1 C-type lectin domain &  Contains 1 GPS domain &  Contains 1 LDL-receptor class A domain &  Contains 6 LRR (leucine-rich) repeats &  Contains 17 PKD domains &  Contains 1 PLAT domain &  Contains 1 REJ domain &  Contains 1 WSC domain


uniprot_information_type:
SwissProt: Q99758 # Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain (By similarity)# Belongs to the ABC transporter superfamily. ABCA family &  Contains 2 ABC transporter domains

uniprot_information:
SwissProt: Q99758 # Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain (By similarity)# Belongs to the ABC transporter superfamily. ABCA family &  Contains 2 ABC transporter domains


uniprot_information_type: SwissProt: Q9NX65
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 6 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q92793 # The KIX domain mediates binding to HIV-1 Tat# Contains 1 bromo domain &  Contains 1 KIX domain &  Contains 2 TAZ-type zinc fingers &  Contains 1 ZZ-type zinc finger

uniprot_information:
SwissProt: Q92793 # The KIX domain mediates binding to HIV-1 Tat# Contains 1 bromo domain &  Contains 1 KIX domain &  Contains 2 TAZ-type zinc fingers &  Contains 1 ZZ-type zinc finger


uniprot_information_type:
SwissProt: Q9Y3D7 # The J-like region, although related to the J domain does not have co-chaperone activity (By similarity)# Belongs to the TIM16/PAM16 family

uniprot_information:
SwissProt: Q9Y3D7 # The J-like region, although related to the J domain does not have co-chaperone activity (By similarity)# Belongs to the TIM16/PAM16 family


uniprot_information_type:
SwissProt: Q49A26 # The A.T hook DNA-binding domain is required for the interaction with MAPK14# Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily &  Contains 1 A.T hook DNA-binding domain &  Contains 1 PWWP domain

uniprot_information:
SwissProt: Q49A26 # The A.T hook DNA-binding domain is required for the interaction with MAPK14# Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily &  Contains 1 A.T hook DNA-binding domain &  Contains 1 PWWP domain


uniprot_information_type: SwissProt: O60437
uniprot_information:
Belongs to the plakin or cytolinker family &  Contains 2 plectin repeats &  Contains 4 spectrin repeats


uniprot_information_type:
SwissProt: Q9UK23 # The tyrosine-based internalization signal may be essential for its retrieval from the plasma membrane to the TGN &  The C-terminal NPFKD sequence is an attractive candidate for either an endocytosis signal acting at the plasma membrane or a retrieval signal acting at the TGN to return the enzyme to the cis/medial-Golgi# Contains 1 EGF-like domain

uniprot_information:
SwissProt: Q9UK23 # The tyrosine-based internalization signal may be essential for its retrieval from the plasma membrane to the TGN &  The C-terminal NPFKD sequence is an attractive candidate for either an endocytosis signal acting at the plasma membrane or a retrieval signal acting at the TGN to return the enzyme to the cis/medial-Golgi# Contains 1 EGF-like domain


uniprot_information_type:
SwissProt: O15524 # The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition &  The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box (By similarity)# Contains 1 SH2 domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: O15524 # The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition &  The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box (By similarity)# Contains 1 SH2 domain &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: P35749 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: P35749 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type: SwissProt: Q96Q15
uniprot_information:
Belongs to the PI3/PI4-kinase family &  Contains 1 FAT domain &  Contains 1 FATC domain &  Contains 1 HEAT repeat &  Contains 1 PI3K/PI4K domain


uniprot_information_type:
SwissProt: Q8TD57 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family &  Contains 21 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q8TD57 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family &  Contains 21 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q05996 # The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida# Belongs to the ZP domain family. ZPA subfamily &  Contains 1 ZP domain

uniprot_information:
SwissProt: Q05996 # The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida# Belongs to the ZP domain family. ZPA subfamily &  Contains 1 ZP domain


uniprot_information_type:
SwissProt: Q68EM7 # The BAR domain mediates the interaction with the coiled coil domain of AMOT, leading to its recruitment to tight junctions# Contains 1 BAR domain &  Contains 1 Rho-GAP domain

uniprot_information:
SwissProt: Q68EM7 # The BAR domain mediates the interaction with the coiled coil domain of AMOT, leading to its recruitment to tight junctions# Contains 1 BAR domain &  Contains 1 Rho-GAP domain


uniprot_information_type:
SwissProt: Q14183 # C2 domain 1 is involved in binding calcium and phospholipids (By similarity)# Contains 2 C2 domains

uniprot_information:
SwissProt: Q14183 # C2 domain 1 is involved in binding calcium and phospholipids (By similarity)# Contains 2 C2 domains


uniprot_information_type:
SwissProt: P27361 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P27361 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q96H86
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 7 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: P0C7X2
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 2 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q9ULZ3 # Interacts with CIAS1/PYPAF1 and PYDC1 via the DAPIN domain# Contains 1 CARD domain &  Contains 1 DAPIN domain

uniprot_information:
SwissProt: Q9ULZ3 # Interacts with CIAS1/PYPAF1 and PYDC1 via the DAPIN domain# Contains 1 CARD domain &  Contains 1 DAPIN domain


uniprot_information_type:
SwissProt: Q8IUQ4 # The RING-type zinc finger domain is essential for ubiquitin ligase activity &  The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family (By similarity)# Belongs to the SINA (Seven in absentia) family &  Contains 1 RING-type zinc finger &  Contains 1 SIAH-type zinc finger

uniprot_information:
SwissProt: Q8IUQ4 # The RING-type zinc finger domain is essential for ubiquitin ligase activity &  The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family (By similarity)# Belongs to the SINA (Seven in absentia) family &  Contains 1 RING-type zinc finger &  Contains 1 SIAH-type zinc finger


uniprot_information_type:
SwissProt: Q2M1K9 # Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and Olf signaling pathways. C2H2-type zinc fingers 14-19 mediate the interaction with SMAD1 and SMAD4, while zinc fingers 28-30 mediate the interaction with EBF1. zinc fingers 2-8 bind the 5'-CCGCCC-3' DNA sequence in concert with EBF1, while zinc fingers 9-13 bind BMP target gene promoters in concert with SMADs# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 30 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q2M1K9 # Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and Olf signaling pathways. C2H2-type zinc fingers 14-19 mediate the interaction with SMAD1 and SMAD4, while zinc fingers 28-30 mediate the interaction with EBF1. zinc fingers 2-8 bind the 5'-CCGCCC-3' DNA sequence in concert with EBF1, while zinc fingers 9-13 bind BMP target gene promoters in concert with SMADs# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 30 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: P13640 # Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines# Belongs to the metallothionein superfamily. Type 1 family

uniprot_information:
SwissProt: P13640 # Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines# Belongs to the metallothionein superfamily. Type 1 family


uniprot_information_type:
SwissProt: Q8TEW6 # PTB domain mediates receptor interaction (By similarity)# Belongs to the DOK family. Type B subfamily &  Contains 1 IRS-type PTB domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q8TEW6 # PTB domain mediates receptor interaction (By similarity)# Belongs to the DOK family. Type B subfamily &  Contains 1 IRS-type PTB domain &  Contains 1 PH domain


uniprot_information_type: SwissProt: Q14028
uniprot_information:
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB1 subfamily &  Contains 1 cyclic nucleotide-binding domain


uniprot_information_type: SwissProt: P19784
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q15628 # Requires the intact DEATH domain to associate with TNFRSF1A/TNFR1# Contains 1 death domain

uniprot_information:
SwissProt: Q15628 # Requires the intact DEATH domain to associate with TNFRSF1A/TNFR1# Contains 1 death domain


uniprot_information_type:
SwissProt: Q9Y613 # Regulated by intramolecular binding to a C-terminal auto-inhibitory domain. Effector binding abolishes this interaction and activates the protein# Belongs to the formin homology family &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain

uniprot_information:
SwissProt: Q9Y613 # Regulated by intramolecular binding to a C-terminal auto-inhibitory domain. Effector binding abolishes this interaction and activates the protein# Belongs to the formin homology family &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


uniprot_information_type:
SwissProt: O00253 # The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin# Contains 1 agouti domain

uniprot_information:
SwissProt: O00253 # The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin# Contains 1 agouti domain


uniprot_information_type:
SwissProt: Q6VN20 # The SPRY domain mediates the interaction with MET (By similarity)# Belongs to the RANBP9/10 family &  Contains 1 B30.2/SPRY domain &  Contains 1 CTLH domain &  Contains 1 LisH domain

uniprot_information:
SwissProt: Q6VN20 # The SPRY domain mediates the interaction with MET (By similarity)# Belongs to the RANBP9/10 family &  Contains 1 B30.2/SPRY domain &  Contains 1 CTLH domain &  Contains 1 LisH domain


uniprot_information_type:
SwissProt: P49588 # Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs (By similarity) &  The C-terminal C-Ala domain (residues 756 to 968), along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs. The human domain can be used in vitro to replace the corresponding domain in E.coli# Belongs to the class-II aminoacyl-tRNA synthetase family

uniprot_information:
SwissProt: P49588 # Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs (By similarity) &  The C-terminal C-Ala domain (residues 756 to 968), along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs. The human domain can be used in vitro to replace the corresponding domain in E.coli# Belongs to the class-II aminoacyl-tRNA synthetase family


uniprot_information_type:
SwissProt: Q08AM6 # The C-terminal domain (residues 523-782) mediates homomeric interactions and is necessary for the formation and maintenance of the PI(3,5)P2 regulatory complex# Belongs to the VAC14 family &  Contains 6 HEAT repeats

uniprot_information:
SwissProt: Q08AM6 # The C-terminal domain (residues 523-782) mediates homomeric interactions and is necessary for the formation and maintenance of the PI(3,5)P2 regulatory complex# Belongs to the VAC14 family &  Contains 6 HEAT repeats


uniprot_information_type: SwissProt: P17027
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 17 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q7L5A8 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the SCS7 family &  Contains 1 cytochrome b5 heme-binding domain

uniprot_information:
SwissProt: Q7L5A8 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the SCS7 family &  Contains 1 cytochrome b5 heme-binding domain


uniprot_information_type:
SwissProt: Q15046 # The N-terminal domain (1-65) of the cytoplasmic isoform is a functional tRNA-binding domain (By similarity), is required for nuclear localization, is involved in the interaction with DARS, but has a repulsive role in the binding to EEF1A1. A central domain (208-259) is involved in homodimerization and is required for interaction with HIV-1 GAG and incorporation into virions. The C-terminal domain (452-597) is not required for interaction with AIMP2# Belongs to the class-II aminoacyl-tRNA synthetase family

uniprot_information:
SwissProt: Q15046 # The N-terminal domain (1-65) of the cytoplasmic isoform is a functional tRNA-binding domain (By similarity), is required for nuclear localization, is involved in the interaction with DARS, but has a repulsive role in the binding to EEF1A1. A central domain (208-259) is involved in homodimerization and is required for interaction with HIV-1 GAG and incorporation into virions. The C-terminal domain (452-597) is not required for interaction with AIMP2# Belongs to the class-II aminoacyl-tRNA synthetase family


uniprot_information_type:
SwissProt: Q9NXF8 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q9NXF8 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: O75154 # The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B)# Contains 2 EF-hand domains &  Contains 1 RBD-FIP domain

uniprot_information:
SwissProt: O75154 # The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B)# Contains 2 EF-hand domains &  Contains 1 RBD-FIP domain


uniprot_information_type: SwissProt: O75808
uniprot_information:
Belongs to the peptidase C2 family &  Contains 1 calpain catalytic domain &  Contains 5 RanBP2-type zinc fingers


uniprot_information_type:
SwissProt: Q96S21 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the small GTPase superfamily. Rab family &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q96S21 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the small GTPase superfamily. Rab family &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q8IXI1
uniprot_information:
Belongs to the mitochondrial Rho GTPase family &  Contains 2 EF-hand domains &  Contains 2 Miro domains


uniprot_information_type:
SwissProt: Q9UNE7 # The TPR domain is essential for ubiquitination mediated by UBE2D1# Contains 3 TPR repeats &  Contains 1 U-box domain

uniprot_information:
SwissProt: Q9UNE7 # The TPR domain is essential for ubiquitination mediated by UBE2D1# Contains 3 TPR repeats &  Contains 1 U-box domain


uniprot_information_type:
SwissProt: O95180 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1H subfamily

uniprot_information:
SwissProt: O95180 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1H subfamily


uniprot_information_type: SwissProt: O94812
uniprot_information:
Contains 2 C2 domains &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 MHD2 (MUNC13 homology domain 2) domain


uniprot_information_type: SwissProt: O00634
uniprot_information:
Contains 3 laminin EGF-like domains &  Contains 1 laminin N-terminal domain &  Contains 1 NTR domain


uniprot_information_type: SwissProt: O15530
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily &  Contains 1 PH domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9NXV2 # The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118# Contains 1 BTB (POZ) domain

uniprot_information:
SwissProt: Q9NXV2 # The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118# Contains 1 BTB (POZ) domain


uniprot_information_type:
SwissProt: Q8NCW0 # Binding to ERLEC1 is mediated by the oligosaccharides linked to the kringle domain (By similarity)# Contains 1 CUB domain &  Contains 1 kringle domain &  Contains 1 WSC domain

uniprot_information:
SwissProt: Q8NCW0 # Binding to ERLEC1 is mediated by the oligosaccharides linked to the kringle domain (By similarity)# Contains 1 CUB domain &  Contains 1 kringle domain &  Contains 1 WSC domain


uniprot_information_type: SwissProt: Q15697
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 3 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type:
SwissProt: Q96EY1 # Modulation of apoptosis, i.e proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domain-dependent# Contains 1 CR-type zinc finger &  Contains 1 J domain

uniprot_information:
SwissProt: Q96EY1 # Modulation of apoptosis, i.e proapoptotic activity of isoform 1 and antiapoptotic activity of isoform 2, is J domain-dependent# Contains 1 CR-type zinc finger &  Contains 1 J domain


uniprot_information_type:
SwissProt: O60291 # The RING finger is required for ubiquitin ligase activity (By similarity)# Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: O60291 # The RING finger is required for ubiquitin ligase activity (By similarity)# Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9ULH7 # The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity (By similarity)# Contains 3 RPEL repeats &  Contains 1 SAP domain

uniprot_information:
SwissProt: Q9ULH7 # The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity (By similarity)# Contains 3 RPEL repeats &  Contains 1 SAP domain


uniprot_information_type: SwissProt: P05771
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O94778 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family

uniprot_information:
SwissProt: O94778 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family


uniprot_information_type:
SwissProt: P24394 # The extracellular domain represents the IL4 binding protein (IL4BP) &  The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation &  Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the type I cytokine receptor family. Type 4 subfamily &  Contains 1 fibronectin type-III domain

uniprot_information:
SwissProt: P24394 # The extracellular domain represents the IL4 binding protein (IL4BP) &  The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation &  Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the type I cytokine receptor family. Type 4 subfamily &  Contains 1 fibronectin type-III domain


uniprot_information_type:
SwissProt: Q9HBE5 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 4 subfamily &  Contains 1 fibronectin type-III domain

uniprot_information:
SwissProt: Q9HBE5 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 4 subfamily &  Contains 1 fibronectin type-III domain


uniprot_information_type:
SwissProt: Q14764 # MVP 3 mediates interaction with PTEN &  MVP 4 mediates interaction with PARP4# Contains 9 MVP (vault) repeats

uniprot_information:
SwissProt: Q14764 # MVP 3 mediates interaction with PTEN &  MVP 4 mediates interaction with PARP4# Contains 9 MVP (vault) repeats


uniprot_information_type:
SwissProt: P20701 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain

uniprot_information:
SwissProt: P20701 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain


uniprot_information_type: SwissProt: Q6ZRS2
uniprot_information:
Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily &  Contains 3 A.T hook DNA-binding domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 HSA domain


uniprot_information_type: SwissProt: Q9H7Z6
uniprot_information:
Belongs to the MYST (SAS/MOZ) family &  Contains 1 C2HC-type zinc finger &  Contains 1 chromo domain


uniprot_information_type: SwissProt: P35637
uniprot_information:
Belongs to the RRM TET family &  Contains 1 RanBP2-type zinc finger &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: P11215 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain

uniprot_information:
SwissProt: P11215 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: P20702 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain

uniprot_information:
SwissProt: P20702 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: O43294 # The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12 &  The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal# Belongs to the paxillin family &  Contains 4 LIM zinc-binding domains

uniprot_information:
SwissProt: O43294 # The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12 &  The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal# Belongs to the paxillin family &  Contains 4 LIM zinc-binding domains


uniprot_information_type:
SwissProt: Q9C0B1 # The 3D-structure of the Fe2OG dioxygenase domain is similar to that of the Fe2OG dioxygenase domain found in the bacterial DNA repair dioxygenase alkB and its mammalian orthologs, but sequence similarity is very low. As a consequence, the domain is not detected by protein signature databases# Belongs to the fto family

uniprot_information:
SwissProt: Q9C0B1 # The 3D-structure of the Fe2OG dioxygenase domain is similar to that of the Fe2OG dioxygenase domain found in the bacterial DNA repair dioxygenase alkB and its mammalian orthologs, but sequence similarity is very low. As a consequence, the domain is not detected by protein signature databases# Belongs to the fto family


uniprot_information_type:
SwissProt: P08253 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 3 fibronectin type-II domains &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: P08253 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 3 fibronectin type-II domains &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: P02795 # Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines# Belongs to the metallothionein superfamily. Type 1 family

uniprot_information:
SwissProt: P02795 # Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines# Belongs to the metallothionein superfamily. Type 1 family


uniprot_information_type:
SwissProt: P04732 # Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines# Belongs to the metallothionein superfamily. Type 1 family

uniprot_information:
SwissProt: P04732 # Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines# Belongs to the metallothionein superfamily. Type 1 family


uniprot_information_type:
SwissProt: Q8N339 # Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines# Belongs to the metallothionein superfamily. Type 1 family

uniprot_information:
SwissProt: Q8N339 # Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines# Belongs to the metallothionein superfamily. Type 1 family


uniprot_information_type:
SwissProt: P04733 # Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines# Belongs to the metallothionein superfamily. Type 1 family

uniprot_information:
SwissProt: P04733 # Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines# Belongs to the metallothionein superfamily. Type 1 family


uniprot_information_type:
SwissProt: P80297 # Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines# Belongs to the metallothionein superfamily. Type 1 family

uniprot_information:
SwissProt: P80297 # Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines# Belongs to the metallothionein superfamily. Type 1 family


uniprot_information_type:
SwissProt: P51511 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: P51511 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: P49711 # The 11 zinc fingers are highly conserved among vertebrates, exhibiting almost identical amino acid sequences. Different subsets or combination of individual zinc fingers gives the ability to CTCF to recognize multiple DNA target sites# Belongs to the CTCF zinc-finger protein family &  Contains 11 C2H2-type zinc fingers

uniprot_information:
SwissProt: P49711 # The 11 zinc fingers are highly conserved among vertebrates, exhibiting almost identical amino acid sequences. Different subsets or combination of individual zinc fingers gives the ability to CTCF to recognize multiple DNA target sites# Belongs to the CTCF zinc-finger protein family &  Contains 11 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q9NPB6 # The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases (By similarity) &  The OPR domain mediates interactions with MAP2K5 (By similarity) &  The PDZ domain mediates the interaction with CRB3# Belongs to the PAR6 family &  Contains 1 OPR domain &  Contains 1 PDZ (DHR) domain &  Contains 1 pseudo-CRIB domain

uniprot_information:
SwissProt: Q9NPB6 # The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases (By similarity) &  The OPR domain mediates interactions with MAP2K5 (By similarity) &  The PDZ domain mediates the interaction with CRB3# Belongs to the PAR6 family &  Contains 1 OPR domain &  Contains 1 PDZ (DHR) domain &  Contains 1 pseudo-CRIB domain


uniprot_information_type:
SwissProt: Q12968 # Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors# Contains 1 RHD (Rel-like) domain

uniprot_information:
SwissProt: Q12968 # Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors# Contains 1 RHD (Rel-like) domain


uniprot_information_type:
SwissProt: Q13425 # The PH 1 domain mediates the oligomerization in a calcium dependent manner (By similarity) &  The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity) &  The SU domain binds calmodulin in a calcium-dependent manner (By similarity)# Belongs to the syntrophin family &  Contains 1 PDZ (DHR) domain &  Contains 2 PH domains &  Contains 1 SU (syntrophin unique) domain

uniprot_information:
SwissProt: Q13425 # The PH 1 domain mediates the oligomerization in a calcium dependent manner (By similarity) &  The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity) &  The SU domain binds calmodulin in a calcium-dependent manner (By similarity)# Belongs to the syntrophin family &  Contains 1 PDZ (DHR) domain &  Contains 2 PH domains &  Contains 1 SU (syntrophin unique) domain


uniprot_information_type:
SwissProt: Q9UN37 # The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle that binds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a subset of ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation along the groove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2)# Belongs to the AAA ATPase family &  Contains 1 MIT domain

uniprot_information:
SwissProt: Q9UN37 # The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle that binds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a subset of ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation along the groove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2)# Belongs to the AAA ATPase family &  Contains 1 MIT domain


uniprot_information_type:
SwissProt: O00308 # The C2 domain is involved in autoinhibition of the catalytic activity by interacting with the HECT domain (By similarity)# Contains 1 C2 domain &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 4 WW domains

uniprot_information:
SwissProt: O00308 # The C2 domain is involved in autoinhibition of the catalytic activity by interacting with the HECT domain (By similarity)# Contains 1 C2 domain &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 4 WW domains


uniprot_information_type: SwissProt: Q9NUU7
uniprot_information:
Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: P00738
uniprot_information:
Belongs to the peptidase S1 family &  Contains 1 peptidase S1 domain &  Contains 2 Sushi (CCP/SCR) domains


uniprot_information_type: SwissProt: P00739
uniprot_information:
Belongs to the peptidase S1 family &  Contains 1 peptidase S1 domain &  Contains 1 Sushi (CCP/SCR) domain


uniprot_information_type: SwissProt: Q92620
uniprot_information:
Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q9NZC7 # The WW 1 domain mediates interaction with TP53, and probably TP73, TFAP2C, LITAF and WBP1# Belongs to the short-chain dehydrogenases/reductases (SDR) family &  Contains 2 WW domains

uniprot_information:
SwissProt: Q9NZC7 # The WW 1 domain mediates interaction with TP53, and probably TP73, TFAP2C, LITAF and WBP1# Belongs to the short-chain dehydrogenases/reductases (SDR) family &  Contains 2 WW domains


uniprot_information_type: SwissProt: P16885
uniprot_information:
Contains 1 C2 domain &  Contains 1 PH domain &  Contains 1 PI-PLC X-box domain &  Contains 1 PI-PLC Y-box domain &  Contains 2 SH2 domains &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q12946 # Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation# Contains 1 fork-head DNA-binding domain

uniprot_information:
SwissProt: Q12946 # Activation domains C-terminal of (and distinct from) the forkhead domains are necessary for transcriptional activation# Contains 1 fork-head DNA-binding domain


uniprot_information_type:
SwissProt: Q8WXH2 # The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids (By similarity)# Belongs to the junctophilin family &  Contains 8 MORN repeats

uniprot_information:
SwissProt: Q8WXH2 # The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids (By similarity)# Belongs to the junctophilin family &  Contains 8 MORN repeats


uniprot_information_type:
SwissProt: Q9H211 # The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination (By similarity)# Belongs to the Cdt1 family

uniprot_information:
SwissProt: Q9H211 # The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination (By similarity)# Belongs to the Cdt1 family


uniprot_information_type:
SwissProt: Q9BQ70 # The C-terminal region mediates transcriptional repression# Belongs to the TCF25 family

uniprot_information:
SwissProt: Q9BQ70 # The C-terminal region mediates transcriptional repression# Belongs to the TCF25 family


uniprot_information_type:
SwissProt: Q13509 # The highly acidic C-terminal region may bind cations such as calcium# Belongs to the tubulin family

uniprot_information:
SwissProt: Q13509 # The highly acidic C-terminal region may bind cations such as calcium# Belongs to the tubulin family


uniprot_information_type:
SwissProt: Q14184 # C2 domain 1 is involved in binding calcium and phospholipids. C2 domain 2 may also play a role in the calcium-dependent targeting to membranes (By similarity)# Contains 2 C2 domains

uniprot_information:
SwissProt: Q14184 # C2 domain 1 is involved in binding calcium and phospholipids. C2 domain 2 may also play a role in the calcium-dependent targeting to membranes (By similarity)# Contains 2 C2 domains


uniprot_information_type:
SwissProt: Q9UNE2 # The N-terminus of the RabBD domain is necessary and sufficient for interaction with RAB27A (By similarity)# Contains 1 FYVE-type zinc finger &  Contains 1 RabBD (Rab-binding) domain

uniprot_information:
SwissProt: Q9UNE2 # The N-terminus of the RabBD domain is necessary and sufficient for interaction with RAB27A (By similarity)# Contains 1 FYVE-type zinc finger &  Contains 1 RabBD (Rab-binding) domain


uniprot_information_type: SwissProt: Q12979
uniprot_information:
Contains 1 C2 domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 Rho-GAP domain


uniprot_information_type:
SwissProt: P46108 # The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation (By similarity) &  The SH2 domain mediates interaction with SHB# Belongs to the CRK family &  Contains 1 SH2 domain &  Contains 2 SH3 domains

uniprot_information:
SwissProt: P46108 # The C-terminal SH3 domain function as a negative modulator for transformation and the N-terminal SH3 domain appears to function as a positive regulator for transformation (By similarity) &  The SH2 domain mediates interaction with SHB# Belongs to the CRK family &  Contains 1 SH2 domain &  Contains 2 SH3 domains


uniprot_information_type:
SwissProt: O00159 # Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to a putative PH domain present in its tail domain (By similarity)# Contains 2 IQ domains &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: O00159 # Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to a putative PH domain present in its tail domain (By similarity)# Contains 2 IQ domains &  Contains 1 myosin head-like domain


uniprot_information_type:
SwissProt: Q6P2Q9 # The MPN domain has structural similarity with viral ribonucleases and RNase H, but unlike RNases, it does not bind any metal ions# Contains 1 MPN (JAB/Mov34) domain

uniprot_information:
SwissProt: Q6P2Q9 # The MPN domain has structural similarity with viral ribonucleases and RNase H, but unlike RNases, it does not bind any metal ions# Contains 1 MPN (JAB/Mov34) domain


uniprot_information_type:
SwissProt: Q8NER1 # The association domain (AD) is necessary for self-association (By similarity)# Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily &  Contains 6 ANK repeats

uniprot_information:
SwissProt: Q8NER1 # The association domain (AD) is necessary for self-association (By similarity)# Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily &  Contains 6 ANK repeats


uniprot_information_type:
SwissProt: P38570 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain

uniprot_information:
SwissProt: P38570 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q8IZL8 # The Glu-rich region mediates histones interaction &  The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1#

uniprot_information:
SwissProt: Q8IZL8 # The Glu-rich region mediates histones interaction &  The Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are required for the association with nuclear receptor ESR1#


uniprot_information_type: SwissProt: Q04844
uniprot_information:
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily


uniprot_information_type: SwissProt: O94983
uniprot_information:
Belongs to the CAMTA family &  Contains 3 ANK repeats &  Contains 1 CG-1 DNA-binding domain &  Contains 1 IPT/TIG domain &  Contains 2 IQ domains


uniprot_information_type: SwissProt: Q9C000
uniprot_information:
Belongs to the NLRP family &  Contains 1 CARD domain &  Contains 1 DAPIN domain &  Contains 7 LRR (leucine-rich) repeats &  Contains 1 NACHT domain


uniprot_information_type:
SwissProt: P78352 # The PDZ domain 3 mediates interaction with ADR1B &  The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to post-synaptic density# Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 3 PDZ (DHR) domains &  Contains 1 SH3 domain

uniprot_information:
SwissProt: P78352 # The PDZ domain 3 mediates interaction with ADR1B &  The L27 domain near the N-terminus of isoform 2 is required for HGS/HRS-dependent targeting to post-synaptic density# Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 3 PDZ (DHR) domains &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P04637 # The nuclear export signal acts as a transcriptional repression domain# Belongs to the p53 family

uniprot_information:
SwissProt: P04637 # The nuclear export signal acts as a transcriptional repression domain# Belongs to the p53 family


uniprot_information_type:
SwissProt: O43448 # Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (Probable)# Belongs to the shaker potassium channel beta subunit family

uniprot_information:
SwissProt: O43448 # Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (Probable)# Belongs to the shaker potassium channel beta subunit family


uniprot_information_type: SwissProt: Q96GD4
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P35580 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: P35580 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type:
SwissProt: Q9UKX3 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: Q9UKX3 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type:
SwissProt: P13535 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: P13535 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type:
SwissProt: Q9Y623 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: Q9Y623 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type:
SwissProt: P12882 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: P12882 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type:
SwissProt: Q9UKX2 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: Q9UKX2 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type:
SwissProt: P11055 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: P11055 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type:
SwissProt: O75376 # The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3) &  The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity)# Belongs to the N-CoR nuclear receptor corepressors family &  Contains 2 SANT domains

uniprot_information:
SwissProt: O75376 # The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3) &  The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity)# Belongs to the N-CoR nuclear receptor corepressors family &  Contains 2 SANT domains


uniprot_information_type: SwissProt: Q9HBT7
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 14 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type:
SwissProt: Q6ZVM7 # The GAT domain mediates interaction with TOLLIP# Belongs to the TOM1 family &  Contains 1 GAT domain &  Contains 1 VHS domain

uniprot_information:
SwissProt: Q6ZVM7 # The GAT domain mediates interaction with TOLLIP# Belongs to the TOM1 family &  Contains 1 GAT domain &  Contains 1 VHS domain


uniprot_information_type:
SwissProt: O43572 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Contains 2 RGS domains

uniprot_information:
SwissProt: O43572 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Contains 2 RGS domains


uniprot_information_type:
SwissProt: P04004 # The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin# Contains 4 hemopexin-like domains &  Contains 1 SMB (somatomedin-B) domain

uniprot_information:
SwissProt: P04004 # The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin# Contains 4 hemopexin-like domains &  Contains 1 SMB (somatomedin-B) domain


uniprot_information_type:
SwissProt: Q9Y2X7 # The paxillin-binding domain is masked in the full-length protein and is regulated by ARHGEF6 (By similarity)# Contains 3 ANK repeats &  Contains 1 Arf-GAP domain

uniprot_information:
SwissProt: Q9Y2X7 # The paxillin-binding domain is masked in the full-length protein and is regulated by ARHGEF6 (By similarity)# Contains 3 ANK repeats &  Contains 1 Arf-GAP domain


uniprot_information_type:
SwissProt: Q9H239 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: Q9H239 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: Q9UMZ2 # The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2# Contains 1 EH domain

uniprot_information:
SwissProt: Q9UMZ2 # The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2# Contains 1 EH domain


uniprot_information_type: SwissProt: Q9Y2R4
uniprot_information:
Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: P20393 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P20393 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: Q969G3 # The HMG domain is essential for CD4 silencing and CD8 activation; mutation of this domain blocks thymus development (By similarity)# Contains 1 HMG box DNA-binding domain

uniprot_information:
SwissProt: Q969G3 # The HMG domain is essential for CD4 silencing and CD8 activation; mutation of this domain blocks thymus development (By similarity)# Contains 1 HMG box DNA-binding domain


uniprot_information_type:
SwissProt: P08727 # This keratin differs from all other IF proteins in lacking the C-terminal tail domain# Belongs to the intermediate filament family

uniprot_information:
SwissProt: P08727 # This keratin differs from all other IF proteins in lacking the C-terminal tail domain# Belongs to the intermediate filament family


uniprot_information_type: SwissProt: P53396
uniprot_information:
In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family &  In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family


uniprot_information_type:
SwissProt: Q9UQ05 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.3/KCNH4 sub-subfamily &  Contains 1 cyclic nucleotide-binding domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain

uniprot_information:
SwissProt: Q9UQ05 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.3/KCNH4 sub-subfamily &  Contains 1 cyclic nucleotide-binding domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain


uniprot_information_type:
SwissProt: P38398 # The BRCT domains recognize and bind phosphorylated pSXXF motif on proteins. The interaction with the phosphorylated pSXXF motif of FAM175A/Abraxas, recruits BRCA1 at DNA damage sites &  The RING-type zinc finger domain interacts with BAP1# Contains 2 BRCT domains &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: P38398 # The BRCT domains recognize and bind phosphorylated pSXXF motif on proteins. The interaction with the phosphorylated pSXXF motif of FAM175A/Abraxas, recruits BRCA1 at DNA damage sites &  The RING-type zinc finger domain interacts with BAP1# Contains 2 BRCT domains &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9UQL6 # The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm (By similarity)# Belongs to the histone deacetylase family. Type 2 subfamily

uniprot_information:
SwissProt: Q9UQL6 # The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm (By similarity)# Belongs to the histone deacetylase family. Type 2 subfamily


uniprot_information_type:
SwissProt: Q86WV1 # The SH3 domain interacts with FYB# Belongs to the SKAP family &  Contains 1 PH domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q86WV1 # The SH3 domain interacts with FYB# Belongs to the SKAP family &  Contains 1 PH domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: O43791 # The MATH domain interacts with H2AFY and BMI1# Belongs to the Tdpoz family &  Contains 1 BTB (POZ) domain &  Contains 1 MATH domain

uniprot_information:
SwissProt: O43791 # The MATH domain interacts with H2AFY and BMI1# Belongs to the Tdpoz family &  Contains 1 BTB (POZ) domain &  Contains 1 MATH domain


uniprot_information_type:
SwissProt: P78383 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the nucleotide-sugar transporter family. SLC35B subfamily

uniprot_information:
SwissProt: P78383 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the nucleotide-sugar transporter family. SLC35B subfamily


uniprot_information_type:
SwissProt: Q14258 # The RING-type zinc finger is important for ISG15 E3 ligase activity and autoISGylation. AutoISGylation negatively regulates ISG15 E3 ligase activity &  The C-terminal B30.2/SPRY domain interacts with the first N-terminal CARD domain of DDX58# Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q14258 # The RING-type zinc finger is important for ISG15 E3 ligase activity and autoISGylation. AutoISGylation negatively regulates ISG15 E3 ligase activity &  The C-terminal B30.2/SPRY domain interacts with the first N-terminal CARD domain of DDX58# Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: O95153 # The SH3 and proline-rich domain is required for the interaction with BZRP and the second SH3 domain mediates binding to a proline-rich motif in RIMS1 and RIMS2 (By similarity)# Belongs to the RIMBP family &  Contains 3 fibronectin type-III domains &  Contains 3 SH3 domains

uniprot_information:
SwissProt: O95153 # The SH3 and proline-rich domain is required for the interaction with BZRP and the second SH3 domain mediates binding to a proline-rich motif in RIMS1 and RIMS2 (By similarity)# Belongs to the RIMBP family &  Contains 3 fibronectin type-III domains &  Contains 3 SH3 domains


uniprot_information_type: SwissProt: Q9NYA4
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily &  Contains 1 FYVE-type zinc finger &  Contains 1 myotubularin phosphatase domain


uniprot_information_type:
SwissProt: Q8IWB6 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily &  Contains 3 ANK repeats &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q8IWB6 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily &  Contains 3 ANK repeats &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O94972
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 MATH domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q7RTN6 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q7RTN6 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P35499 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily &  Contains 1 IQ domain

uniprot_information:
SwissProt: P35499 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily &  Contains 1 IQ domain


uniprot_information_type: SwissProt: P13598
uniprot_information:
Belongs to the immunoglobulin superfamily. ICAM family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: O75460
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 1 KEN domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P16284 # The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity# Contains 6 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: P16284 # The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity# Contains 6 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: P17844
uniprot_information:
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q9HAU4 # The second and third WW domains are responsible for interaction with the PY-motif of R-SMAD (SMAD1, SMAD2 and SMAD3) &  The C2 domain is involved in autoinhibition of the catalytic activity by interacting with the HECT domain# Contains 1 C2 domain &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 3 WW domains

uniprot_information:
SwissProt: Q9HAU4 # The second and third WW domains are responsible for interaction with the PY-motif of R-SMAD (SMAD1, SMAD2 and SMAD3) &  The C2 domain is involved in autoinhibition of the catalytic activity by interacting with the HECT domain# Contains 1 C2 domain &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 3 WW domains


uniprot_information_type: SwissProt: Q58EX2
uniprot_information:
Contains 13 fibronectin type-III domains &  Contains 6 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q9NZ52 # The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif) &  The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis &  The unstructured hinge region contains clathrin-binding and an autoinhibitory (AC-LL) motifs &  The GAE domain binds accessory proteins regulating GGAs function# Belongs to the GGA protein family &  Contains 1 GAE domain &  Contains 1 GAT domain &  Contains 1 VHS domain

uniprot_information:
SwissProt: Q9NZ52 # The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif) &  The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis &  The unstructured hinge region contains clathrin-binding and an autoinhibitory (AC-LL) motifs &  The GAE domain binds accessory proteins regulating GGAs function# Belongs to the GGA protein family &  Contains 1 GAE domain &  Contains 1 GAT domain &  Contains 1 VHS domain


uniprot_information_type:
SwissProt: P62993 # The SH3 domains mediate interaction with RALGPS1 and SHB# Belongs to the GRB2/sem-5/DRK family &  Contains 1 SH2 domain &  Contains 2 SH3 domains

uniprot_information:
SwissProt: P62993 # The SH3 domains mediate interaction with RALGPS1 and SHB# Belongs to the GRB2/sem-5/DRK family &  Contains 1 SH2 domain &  Contains 2 SH3 domains


uniprot_information_type:
SwissProt: Q969T9 # The WW-binding 1 motif mediates interaction with NEDD4 (By similarity)# Contains 1 GRAM domain

uniprot_information:
SwissProt: Q969T9 # The WW-binding 1 motif mediates interaction with NEDD4 (By similarity)# Contains 1 GRAM domain


uniprot_information_type: SwissProt: Q92817
uniprot_information:
Belongs to the plakin or cytolinker family &  Contains 7 plectin repeats &  Contains 1 spectrin repeat


uniprot_information_type:
SwissProt: Q9UPT5 # The N-terminus is involved in SEC8 and ARHQ binding (By similarity) &  The C-terminus is required for translocation to the plasma membrane (By similarity)# Belongs to the EXO70 family

uniprot_information:
SwissProt: Q9UPT5 # The N-terminus is involved in SEC8 and ARHQ binding (By similarity) &  The C-terminus is required for translocation to the plasma membrane (By similarity)# Belongs to the EXO70 family


uniprot_information_type:
SwissProt: Q6NYC1 # The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus# Belongs to the JMJD6 family &  Contains 1 JmjC domain

uniprot_information:
SwissProt: Q6NYC1 # The nuclear localization signal motifs are necessary and sufficient to target it into the nucleus# Belongs to the JMJD6 family &  Contains 1 JmjC domain


uniprot_information_type:
SwissProt: O14543 # The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition &  The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SH2 domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: O14543 # The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition &  The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SH2 domain &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: Q9UFH2 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family &  Contains 13 LRR (leucine-rich) repeats &  Contains 3 TPR repeats

uniprot_information:
SwissProt: Q9UFH2 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family &  Contains 13 LRR (leucine-rich) repeats &  Contains 3 TPR repeats


uniprot_information_type: SwissProt: Q08380
uniprot_information:
Contains 1 BACK (BTB/Kelch associated) domain &  Contains 1 BTB (POZ) domain &  Contains 1 SRCR domain


uniprot_information_type:
SwissProt: Q8TAT6 # Binds ubiquitinated proteins via its RanBP2-type zinc finger# Belongs to the NPL4 family &  Contains 1 RanBP2-type zinc finger

uniprot_information:
SwissProt: Q8TAT6 # Binds ubiquitinated proteins via its RanBP2-type zinc finger# Belongs to the NPL4 family &  Contains 1 RanBP2-type zinc finger


uniprot_information_type:
SwissProt: Q12829 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the small GTPase superfamily. Rab family &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q12829 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the small GTPase superfamily. Rab family &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: P36955 # The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity# Belongs to the serpin family

uniprot_information:
SwissProt: P36955 # The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity# Belongs to the serpin family


uniprot_information_type: SwissProt: Q14526
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily &  Contains 1 BTB (POZ) domain &  Contains 5 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: P43034 # Dimerization mediated by the LisH domain may be required to activate dynein (By similarity)# Belongs to the WD repeat LIS1/nudF family &  Contains 1 LisH domain &  Contains 7 WD repeats

uniprot_information:
SwissProt: P43034 # Dimerization mediated by the LisH domain may be required to activate dynein (By similarity)# Belongs to the WD repeat LIS1/nudF family &  Contains 1 LisH domain &  Contains 7 WD repeats


uniprot_information_type:
SwissProt: P32121 # The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1 (By similarity)# Belongs to the arrestin family

uniprot_information:
SwissProt: P32121 # The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1 (By similarity)# Belongs to the arrestin family


uniprot_information_type: SwissProt: O43896
uniprot_information:
Belongs to the kinesin-like protein family. Unc-104 subfamily &  Contains 1 FHA domain &  Contains 1 kinesin-motor domain


uniprot_information_type:
SwissProt: P35125 # The Rab-GAP TBC domain lacks GTPase activator activity but is necessary for interaction with ARF6# Belongs to the peptidase C19 family &  Contains 1 Rab-GAP TBC domain

uniprot_information:
SwissProt: P35125 # The Rab-GAP TBC domain lacks GTPase activator activity but is necessary for interaction with ARF6# Belongs to the peptidase C19 family &  Contains 1 Rab-GAP TBC domain


uniprot_information_type:
SwissProt: Q15027 # PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes# Contains 3 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 BAR domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q15027 # PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes# Contains 3 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 BAR domain &  Contains 1 PH domain


uniprot_information_type: SwissProt: Q13470
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family &  Contains 1 protein kinase domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: P11230
uniprot_information:
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-1/CHRNB1 sub-subfamily


uniprot_information_type:
SwissProt: Q9P225 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family &  Contains 5 LRR (leucine-rich) repeats &  Contains 5 TPR repeats

uniprot_information:
SwissProt: Q9P225 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family &  Contains 5 LRR (leucine-rich) repeats &  Contains 5 TPR repeats


uniprot_information_type: SwissProt: O15067
uniprot_information:
In the N-terminal section; belongs to the FGAMS family &  Contains 1 glutamine amidotransferase type-1 domain


uniprot_information_type:
SwissProt: Q9NYC9 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function# Belongs to the dynein heavy chain family

uniprot_information:
SwissProt: Q9NYC9 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function# Belongs to the dynein heavy chain family


uniprot_information_type: SwissProt: Q9Y5S1
uniprot_information:
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily &  Contains 6 ANK repeats


uniprot_information_type: SwissProt: Q9UKN7
uniprot_information:
Contains 1 FERM domain &  Contains 3 IQ domains &  Contains 1 myosin head-like domain &  Contains 2 MyTH4 domains &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: O95208 # The NPF repeat domain is involved in EPS15 binding &  The DPW repeat domain is involved in AP-2 and clathrin binding# Belongs to the epsin family &  Contains 1 ENTH (epsin N-terminal homology) domain &  Contains 2 UIM (ubiquitin-interacting motif) repeats

uniprot_information:
SwissProt: O95208 # The NPF repeat domain is involved in EPS15 binding &  The DPW repeat domain is involved in AP-2 and clathrin binding# Belongs to the epsin family &  Contains 1 ENTH (epsin N-terminal homology) domain &  Contains 2 UIM (ubiquitin-interacting motif) repeats


uniprot_information_type:
SwissProt: Q13164 # The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell &  The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q13164 # The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell &  The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9Y6I7 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SOCS box domain &  Contains 6 WD repeats

uniprot_information:
SwissProt: Q9Y6I7 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SOCS box domain &  Contains 6 WD repeats


uniprot_information_type: SwissProt: Q8IVT5
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O00182 # Contains two homologous but distinct carbohydrate-binding domains# Contains 2 galectin domains

uniprot_information:
SwissProt: O00182 # Contains two homologous but distinct carbohydrate-binding domains# Contains 2 galectin domains


uniprot_information_type: SwissProt: Q9UBE8
uniprot_information:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9BUZ4 # The coiled coil domain mediates homo- and hetero-oligomerization (By similarity) &  The MATH/TRAF domain binds to receptor cytoplasmic domains (By similarity)# Belongs to the TNF receptor-associated factor family. B subfamily &  Contains 1 MATH domain &  Contains 1 RING-type zinc finger &  Contains 3 TRAF-type zinc fingers

uniprot_information:
SwissProt: Q9BUZ4 # The coiled coil domain mediates homo- and hetero-oligomerization (By similarity) &  The MATH/TRAF domain binds to receptor cytoplasmic domains (By similarity)# Belongs to the TNF receptor-associated factor family. B subfamily &  Contains 1 MATH domain &  Contains 1 RING-type zinc finger &  Contains 3 TRAF-type zinc fingers


uniprot_information_type:
SwissProt: P05813 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains

uniprot_information:
SwissProt: P05813 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains


uniprot_information_type:
SwissProt: O75976 # There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity# Belongs to the peptidase M14 family

uniprot_information:
SwissProt: O75976 # There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity# Belongs to the peptidase M14 family


uniprot_information_type: SwissProt: P49916
uniprot_information:
Belongs to the ATP-dependent DNA ligase family &  Contains 1 BRCT domain &  Contains 1 PARP-type zinc finger


uniprot_information_type:
SwissProt: P48742 # The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the homeobox (By similarity)# Contains 1 homeobox DNA-binding domain &  Contains 2 LIM zinc-binding domains

uniprot_information:
SwissProt: P48742 # The LIM domains exert a negative regulatory function and disruption of the LIM domains produces an activated form. In addition, two activation domains and a negative regulatory domain exist C-terminally to the homeobox (By similarity)# Contains 1 homeobox DNA-binding domain &  Contains 2 LIM zinc-binding domains


uniprot_information_type:
SwissProt: O14512 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation# Contains 1 SH2 domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: O14512 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation# Contains 1 SH2 domain &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q14451
uniprot_information:
Belongs to the GRB7/10/14 family &  Contains 1 PH domain &  Contains 1 Ras-associating domain &  Contains 1 SH2 domain


uniprot_information_type:
SwissProt: P10827 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P10827 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: O15234 # The coiled coil domain may be involved in oligomerization# Belongs to the CASC3 family

uniprot_information:
SwissProt: O15234 # The coiled coil domain may be involved in oligomerization# Belongs to the CASC3 family


uniprot_information_type:
SwissProt: P10276 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P10276 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: Q9NYR9 # In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins# Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily

uniprot_information:
SwissProt: Q9NYR9 # In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins# Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily


uniprot_information_type: SwissProt: Q13057
uniprot_information:
In the central section; belongs to the eukaryotic coaD family &  Contains 1 DPCK (dephospho-CoA kinase) domain


uniprot_information_type:
SwissProt: P61289 # The C-terminal sequences affect heptamer stability and proteasome affinity# Belongs to the PA28 family

uniprot_information:
SwissProt: P61289 # The C-terminal sequences affect heptamer stability and proteasome affinity# Belongs to the PA28 family


uniprot_information_type:
SwissProt: Q14596 # The OPR domain mediates interaction with SQSTM1# Contains 1 OPR domain &  Contains 1 UBA domain &  Contains 1 ZZ-type zinc finger

uniprot_information:
SwissProt: Q14596 # The OPR domain mediates interaction with SQSTM1# Contains 1 OPR domain &  Contains 1 UBA domain &  Contains 1 ZZ-type zinc finger


uniprot_information_type:
SwissProt: Q14562 # The RS domain confers a nuclear localization signal, and appears to facilitate the interaction with the spliceosome# Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 S1 motif domain

uniprot_information:
SwissProt: Q14562 # The RS domain confers a nuclear localization signal, and appears to facilitate the interaction with the spliceosome# Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 S1 motif domain


uniprot_information_type:
SwissProt: Q14332 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain

uniprot_information:
SwissProt: Q14332 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain


uniprot_information_type:
SwissProt: O75078 # A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: O75078 # A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain


uniprot_information_type: SwissProt: O95466
uniprot_information:
Belongs to the formin homology family &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


uniprot_information_type:
SwissProt: P10636 # The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats# Contains 4 Tau/MAP repeats

uniprot_information:
SwissProt: P10636 # The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats# Contains 4 Tau/MAP repeats


uniprot_information_type:
SwissProt: O95251 # The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L &  The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction (By similarity)# Belongs to the MYST (SAS/MOZ) family &  Contains 1 C2HC-type zinc finger

uniprot_information:
SwissProt: O95251 # The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L &  The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction (By similarity)# Belongs to the MYST (SAS/MOZ) family &  Contains 1 C2HC-type zinc finger


uniprot_information_type: SwissProt: Q9H201
uniprot_information:
Belongs to the epsin family &  Contains 1 ENTH (epsin N-terminal homology) domain &  Contains 2 UIM (ubiquitin-interacting motif) repeats


uniprot_information_type:
SwissProt: O43497 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position &  The linker region between repeat III and IV probably play a role in the inactivation of the channel. The C-terminal part may be implicated in the anchoring of the protein to the membrane, this by interfering/restricting its lateral diffusion# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1G subfamily

uniprot_information:
SwissProt: O43497 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position &  The linker region between repeat III and IV probably play a role in the inactivation of the channel. The C-terminal part may be implicated in the anchoring of the protein to the membrane, this by interfering/restricting its lateral diffusion# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1G subfamily


uniprot_information_type: SwissProt: P52429
uniprot_information:
Belongs to the eukaryotic diacylglycerol kinase family &  Contains 1 DAGKc domain &  Contains 2 phorbol-ester/DAG-type zinc fingers


uniprot_information_type:
SwissProt: Q92667 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Contains 1 KH domain &  Contains 1 Tudor domain

uniprot_information:
SwissProt: Q92667 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Contains 1 KH domain &  Contains 1 Tudor domain


uniprot_information_type:
SwissProt: P23443 # The autoinhibitory domain is believed to block phosphorylation within the AGC-kinase C-terminal domain and the activation loop &  The TOS (TOR signaling) motif is essential for activation by mTORC1 (By similarity)# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P23443 # The autoinhibitory domain is believed to block phosphorylation within the AGC-kinase C-terminal domain and the activation loop &  The TOS (TOR signaling) motif is essential for activation by mTORC1 (By similarity)# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9UBG0 # C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner &  Fibronectin type-II domain mediates collagen-binding &  Ricin B-type lectin domain contacts with the second C-type lectin domain (By similarity)# Contains 8 C-type lectin domains &  Contains 1 fibronectin type-II domain &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q9UBG0 # C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner &  Fibronectin type-II domain mediates collagen-binding &  Ricin B-type lectin domain contacts with the second C-type lectin domain (By similarity)# Contains 8 C-type lectin domains &  Contains 1 fibronectin type-II domain &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: Q9H252 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily &  Contains 1 cyclic nucleotide-binding domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain

uniprot_information:
SwissProt: Q9H252 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily &  Contains 1 cyclic nucleotide-binding domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain


uniprot_information_type: SwissProt: Q86XP3
uniprot_information:
Belongs to the DEAD box helicase family. DDX42 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: O75916 # In photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments# Contains 1 DEP domain &  Contains 1 G protein gamma domain &  Contains 1 RGS domain

uniprot_information:
SwissProt: O75916 # In photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments# Contains 1 DEP domain &  Contains 1 G protein gamma domain &  Contains 1 RGS domain


uniprot_information_type:
SwissProt: Q12830 # The second PHD-type zinc finger mediates binding to histone H3-K4Me3# Belongs to the PBTF family &  Contains 1 bromo domain &  Contains 1 DDT domain &  Contains 2 PHD-type zinc fingers

uniprot_information:
SwissProt: Q12830 # The second PHD-type zinc finger mediates binding to histone H3-K4Me3# Belongs to the PBTF family &  Contains 1 bromo domain &  Contains 1 DDT domain &  Contains 2 PHD-type zinc fingers


uniprot_information_type:
SwissProt: P52292 # Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import &  The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity) &  The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)# Belongs to the importin alpha family &  Contains 10 ARM repeats &  Contains 1 IBB domain

uniprot_information:
SwissProt: P52292 # Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import &  The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity) &  The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)# Belongs to the importin alpha family &  Contains 10 ARM repeats &  Contains 1 IBB domain


uniprot_information_type: SwissProt: Q96JP2
uniprot_information:
Contains 1 IQ domain &  Contains 1 myosin head-like domain &  Contains 1 MyTH4 domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P16144 # The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230# Belongs to the integrin beta chain family &  Contains 1 Calx-beta domain &  Contains 4 fibronectin type-III domains &  Contains 1 PSI domain &  Contains 1 VWFA domain

uniprot_information:
SwissProt: P16144 # The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230# Belongs to the integrin beta chain family &  Contains 1 Calx-beta domain &  Contains 4 fibronectin type-III domains &  Contains 1 PSI domain &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: O15392 # The BIR repeat is necessary and sufficient for HBXIP binding# Belongs to the IAP family &  Contains 1 BIR repeat

uniprot_information:
SwissProt: O15392 # The BIR repeat is necessary and sufficient for HBXIP binding# Belongs to the IAP family &  Contains 1 BIR repeat


uniprot_information_type: SwissProt: Q32NB8
uniprot_information:
Belongs to the CDP-alcohol phosphatidyltransferase class-II family &  Contains 2 PLD phosphodiesterase domains


uniprot_information_type:
SwissProt: Q96FZ7 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components# Belongs to the SNF7 family

uniprot_information:
SwissProt: Q96FZ7 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components# Belongs to the SNF7 family


uniprot_information_type:
SwissProt: Q9UQB8 # The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation &  The SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH# Contains 1 IMD (IRSp53/MIM homology) domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q9UQB8 # The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation &  The SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH# Contains 1 IMD (IRSp53/MIM homology) domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: O14964 # Has a double-sided UIM that can bind 2 ubiquitin molecules, one on each side of the helix# Contains 1 FYVE-type zinc finger &  Contains 1 UIM (ubiquitin-interacting motif) repeat &  Contains 1 VHS domain

uniprot_information:
SwissProt: O14964 # Has a double-sided UIM that can bind 2 ubiquitin molecules, one on each side of the helix# Contains 1 FYVE-type zinc finger &  Contains 1 UIM (ubiquitin-interacting motif) repeat &  Contains 1 VHS domain


uniprot_information_type:
SwissProt: Q13098 # The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity) &  The N-terminal part (1-216), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression# Belongs to the CSN1 family &  Contains 1 PCI domain

uniprot_information:
SwissProt: Q13098 # The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity) &  The N-terminal part (1-216), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression# Belongs to the CSN1 family &  Contains 1 PCI domain


uniprot_information_type:
SwissProt: Q01167 # The C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity# Contains 1 FHA domain &  Contains 1 fork-head DNA-binding domain

uniprot_information:
SwissProt: Q01167 # The C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity# Contains 1 FHA domain &  Contains 1 fork-head DNA-binding domain


uniprot_information_type:
SwissProt: Q92539 # Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity (By similarity) &  Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif (By similarity)# Belongs to the lipin family

uniprot_information:
SwissProt: Q92539 # Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity (By similarity) &  Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif (By similarity)# Belongs to the lipin family


uniprot_information_type:
SwissProt: O43829 # The BTB/POZ domain seems to direct the protein to discrete regions in the nucleus# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 5 C2H2-type zinc fingers

uniprot_information:
SwissProt: O43829 # The BTB/POZ domain seems to direct the protein to discrete regions in the nucleus# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 5 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q53F39 # The di-lysine motif (KxKxx) acts as an endoplasmic reticulum retrieval signal# Belongs to the metallophosphoesterase superfamily. MPPE1 family

uniprot_information:
SwissProt: Q53F39 # The di-lysine motif (KxKxx) acts as an endoplasmic reticulum retrieval signal# Belongs to the metallophosphoesterase superfamily. MPPE1 family


uniprot_information_type: SwissProt: P17706
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: Q13464 # The C-terminal auto-inhibitory domain interferes with kinase activity. RHOA binding leads to a conformation change and activation of the kinase. Truncated ROCK1 is constitutively activated# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain &  Contains 1 REM (Hr1) repeat

uniprot_information:
SwissProt: Q13464 # The C-terminal auto-inhibitory domain interferes with kinase activity. RHOA binding leads to a conformation change and activation of the kinase. Truncated ROCK1 is constitutively activated# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain &  Contains 1 REM (Hr1) repeat


uniprot_information_type:
SwissProt: O15118 # A cysteine-rich N-terminal domain and a C-terminal domain containing a di-leucine motif necessary for lysosomal targeting are critical for mobilization of cholesterol from lysosomes# Belongs to the patched family &  Contains 1 SSD (sterol-sensing) domain

uniprot_information:
SwissProt: O15118 # A cysteine-rich N-terminal domain and a C-terminal domain containing a di-leucine motif necessary for lysosomal targeting are critical for mobilization of cholesterol from lysosomes# Belongs to the patched family &  Contains 1 SSD (sterol-sensing) domain


uniprot_information_type:
SwissProt: P55087 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family

uniprot_information:
SwissProt: P55087 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family


uniprot_information_type:
SwissProt: Q14574 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 5 cadherin domains

uniprot_information:
SwissProt: Q14574 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 5 cadherin domains


uniprot_information_type:
SwissProt: Q02487 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 5 cadherin domains

uniprot_information:
SwissProt: Q02487 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 5 cadherin domains


uniprot_information_type:
SwissProt: Q08554 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 5 cadherin domains

uniprot_information:
SwissProt: Q08554 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 5 cadherin domains


uniprot_information_type:
SwissProt: O75928 # The LXXLL motif is a transcriptional coregulator signature# Belongs to the PIAS family &  Contains 1 PINIT domain &  Contains 1 SAP domain &  Contains 1 SP-RING-type zinc finger

uniprot_information:
SwissProt: O75928 # The LXXLL motif is a transcriptional coregulator signature# Belongs to the PIAS family &  Contains 1 PINIT domain &  Contains 1 SAP domain &  Contains 1 SP-RING-type zinc finger


uniprot_information_type:
SwissProt: Q8IYF1 # The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]# Contains 1 TFIIS N-terminal domain

uniprot_information:
SwissProt: Q8IYF1 # The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]# Contains 1 TFIIS N-terminal domain


uniprot_information_type:
SwissProt: Q9UIS9 # The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions &  The third CXXC-type zinc finger mediates binding to non-methylated CpG dinucleotides &  The transcriptional repression domain (TRD) is involved in transcription repression and in protein interactions# Contains 3 CXXC-type zinc fingers &  Contains 1 MBD (methyl-CpG-binding) domain

uniprot_information:
SwissProt: Q9UIS9 # The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions &  The third CXXC-type zinc finger mediates binding to non-methylated CpG dinucleotides &  The transcriptional repression domain (TRD) is involved in transcription repression and in protein interactions# Contains 3 CXXC-type zinc fingers &  Contains 1 MBD (methyl-CpG-binding) domain


uniprot_information_type:
SwissProt: Q9P0U4 # The acidic domain carries the potential to activate transcription# Contains 1 CXXC-type zinc finger &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: Q9P0U4 # The acidic domain carries the potential to activate transcription# Contains 1 CXXC-type zinc finger &  Contains 1 PHD-type zinc finger


uniprot_information_type:
SwissProt: Q5U5Q3 # Binds RNA through its KH domains# Contains 2 KH domains &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q5U5Q3 # Binds RNA through its KH domains# Contains 2 KH domains &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: P10415 # The BH4 motif is required for anti-apoptotic activity and for interaction with RAF-1# Belongs to the Bcl-2 family

uniprot_information:
SwissProt: P10415 # The BH4 motif is required for anti-apoptotic activity and for interaction with RAF-1# Belongs to the Bcl-2 family


uniprot_information_type:
SwissProt: O75351 # The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle that binds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a subset of ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation along the groove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2)# Belongs to the AAA ATPase family &  Contains 1 MIT domain

uniprot_information:
SwissProt: O75351 # The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle that binds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a subset of ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation along the groove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2)# Belongs to the AAA ATPase family &  Contains 1 MIT domain


uniprot_information_type:
SwissProt: Q9GZX9 # The N-terminal domain is sufficient to interact with BMP4 (By similarity)# Belongs to the twisted gastrulation protein family

uniprot_information:
SwissProt: Q9GZX9 # The N-terminal domain is sufficient to interact with BMP4 (By similarity)# Belongs to the twisted gastrulation protein family


uniprot_information_type:
SwissProt: Q9BUF5 # The highly acidic C-terminal region may bind cations such as calcium# Belongs to the tubulin family

uniprot_information:
SwissProt: Q9BUF5 # The highly acidic C-terminal region may bind cations such as calcium# Belongs to the tubulin family


uniprot_information_type:
SwissProt: Q92908 # The GATA-type zinc fingers mediate interaction with LMCD1 (By similarity)# Contains 2 GATA-type zinc fingers

uniprot_information:
SwissProt: Q92908 # The GATA-type zinc fingers mediate interaction with LMCD1 (By similarity)# Contains 2 GATA-type zinc fingers


uniprot_information_type:
SwissProt: Q16787 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domain G is globular# Contains 15 laminin EGF-like domains &  Contains 5 laminin G-like domains &  Contains 1 laminin IV type A domain &  Contains 1 laminin N-terminal domain

uniprot_information:
SwissProt: Q16787 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domain G is globular# Contains 15 laminin EGF-like domains &  Contains 5 laminin G-like domains &  Contains 1 laminin IV type A domain &  Contains 1 laminin N-terminal domain


uniprot_information_type:
SwissProt: Q02413 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 4 cadherin domains

uniprot_information:
SwissProt: Q02413 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 4 cadherin domains


uniprot_information_type:
SwissProt: P32926 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 4 cadherin domains

uniprot_information:
SwissProt: P32926 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 4 cadherin domains


uniprot_information_type:
SwissProt: Q14126 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 4 cadherin domains

uniprot_information:
SwissProt: Q14126 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 4 cadherin domains


uniprot_information_type:
SwissProt: P02766 # Each monomer has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel# Belongs to the transthyretin family

uniprot_information:
SwissProt: P02766 # Each monomer has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel# Belongs to the transthyretin family


uniprot_information_type:
SwissProt: Q8WVD3 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8WVD3 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9Y4J8 # The coiled coil domain mediates the interaction with dystrophin and utrophin (By similarity)# Belongs to the dystrophin family. Dystrobrevin subfamily &  Contains 1 ZZ-type zinc finger

uniprot_information:
SwissProt: Q9Y4J8 # The coiled coil domain mediates the interaction with dystrophin and utrophin (By similarity)# Belongs to the dystrophin family. Dystrobrevin subfamily &  Contains 1 ZZ-type zinc finger


uniprot_information_type:
SwissProt: Q15555 # Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1# Belongs to the MAPRE family &  Contains 1 CH (calponin-homology) domain &  Contains 1 EB1 C-terminal domain

uniprot_information:
SwissProt: Q15555 # Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1# Belongs to the MAPRE family &  Contains 1 CH (calponin-homology) domain &  Contains 1 EB1 C-terminal domain


uniprot_information_type:
SwissProt: Q10472 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q10472 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type: SwissProt: Q96EN8
uniprot_information:
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily &  Contains 1 MOSC domain


uniprot_information_type: SwissProt: Q6ZMC9
uniprot_information:
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q13485 # The MH1 and MH2 domains are necessary for interaction with RBPMS# Belongs to the dwarfin/SMAD family &  Contains 1 MH1 (MAD homology 1) domain &  Contains 1 MH2 (MAD homology 2) domain

uniprot_information:
SwissProt: Q13485 # The MH1 and MH2 domains are necessary for interaction with RBPMS# Belongs to the dwarfin/SMAD family &  Contains 1 MH1 (MAD homology 1) domain &  Contains 1 MH2 (MAD homology 2) domain


uniprot_information_type:
SwissProt: Q9UNA4 # The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity# Belongs to the DNA polymerase type-Y family &  Contains 1 umuC domain

uniprot_information:
SwissProt: Q9UNA4 # The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity# Belongs to the DNA polymerase type-Y family &  Contains 1 umuC domain


uniprot_information_type: SwissProt: Q9UDY8
uniprot_information:
Belongs to the peptidase C14B family &  Contains 1 death domain &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q13794 # The BH3 motif is essential for pro-apoptotic activity# Belongs to the PMAIP1 family

uniprot_information:
SwissProt: Q13794 # The BH3 motif is essential for pro-apoptotic activity# Belongs to the PMAIP1 family


uniprot_information_type:
SwissProt: O60346 # The PH domain is required for interaction with PRKCB and its dephosphorylation# Contains 19 LRR (leucine-rich) repeats &  Contains 1 PH domain &  Contains 1 PP2C-like domain

uniprot_information:
SwissProt: O60346 # The PH domain is required for interaction with PRKCB and its dephosphorylation# Contains 19 LRR (leucine-rich) repeats &  Contains 1 PH domain &  Contains 1 PP2C-like domain


uniprot_information_type:
SwissProt: O14544 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SH2 domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: O14544 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SH2 domain &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: O95644 # Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors &  The N-terminal transactivation domain (TAD-A) binds to and is activated by Cbp/p300. The dephosphorylated form contains two unmasked nuclear localization signals (NLS), which allow translocation of the protein to the nucleus &  Isoforms C have a C-terminal part with an additional trans-activation domain, TAD-B, which acts as a transcriptional activator. Isoforms B have a shorter C-terminal part without complete TAD-B which acts as a transcriptional repressor# Contains 1 RHD (Rel-like) domain

uniprot_information:
SwissProt: O95644 # Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors &  The N-terminal transactivation domain (TAD-A) binds to and is activated by Cbp/p300. The dephosphorylated form contains two unmasked nuclear localization signals (NLS), which allow translocation of the protein to the nucleus &  Isoforms C have a C-terminal part with an additional trans-activation domain, TAD-B, which acts as a transcriptional activator. Isoforms B have a shorter C-terminal part without complete TAD-B which acts as a transcriptional repressor# Contains 1 RHD (Rel-like) domain


uniprot_information_type:
SwissProt: Q9UJ96 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily

uniprot_information:
SwissProt: Q9UJ96 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily


uniprot_information_type: SwissProt: Q6IQ32
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 4 C2H2-type zinc fingers &  Contains 1 homeobox DNA-binding domain


uniprot_information_type:
SwissProt: P98077 # The PID domain mediates binding to the TrkA receptor# Contains 1 PID domain &  Contains 1 SH2 domain

uniprot_information:
SwissProt: P98077 # The PID domain mediates binding to the TrkA receptor# Contains 1 PID domain &  Contains 1 SH2 domain


uniprot_information_type:
SwissProt: Q86XN8 # Binds RNA through its KH domains (By similarity)# Contains 2 KH domains &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q86XN8 # Binds RNA through its KH domains (By similarity)# Contains 2 KH domains &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9Y5L4 # The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity)# Belongs to the small Tim family

uniprot_information:
SwissProt: Q9Y5L4 # The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity)# Belongs to the small Tim family


uniprot_information_type:
SwissProt: O43765 # The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a# Belongs to the SGT family &  Contains 3 TPR repeats

uniprot_information:
SwissProt: O43765 # The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a# Belongs to the SGT family &  Contains 3 TPR repeats


uniprot_information_type:
SwissProt: Q99961 # An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes (By similarity)# Belongs to the endophilin family &  Contains 1 BAR domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q99961 # An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes (By similarity)# Belongs to the endophilin family &  Contains 1 BAR domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q8IUC6 # The N-terminal region is essential for activation of the IFNB promoter activity# Contains 1 TIR domain

uniprot_information:
SwissProt: Q8IUC6 # The N-terminal region is essential for activation of the IFNB promoter activity# Contains 1 TIR domain


uniprot_information_type: SwissProt: Q9BV35
uniprot_information:
Belongs to the mitochondrial carrier family &  Contains 3 EF-hand domains &  Contains 3 Solcar repeats


uniprot_information_type:
SwissProt: P04350 # The highly acidic C-terminal region may bind cations such as calcium# Belongs to the tubulin family

uniprot_information:
SwissProt: P04350 # The highly acidic C-terminal region may bind cations such as calcium# Belongs to the tubulin family


uniprot_information_type:
SwissProt: Q9NNX6 # The tandem repeat domain, also called neck domain, mediates oligomerization# Contains 1 C-type lectin domain

uniprot_information:
SwissProt: Q9NNX6 # The tandem repeat domain, also called neck domain, mediates oligomerization# Contains 1 C-type lectin domain


uniprot_information_type:
SwissProt: Q8WXI7 # Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail# Contains 2 ANK repeats &  Contains 14 LRR (leucine-rich) repeats &  Contains 56 SEA domains

uniprot_information:
SwissProt: Q8WXI7 # Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail# Contains 2 ANK repeats &  Contains 14 LRR (leucine-rich) repeats &  Contains 56 SEA domains


uniprot_information_type: SwissProt: Q14584
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 14 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: P26358 # The N-terminal part is required for homodimerization and acts as a regulatory domain# Belongs to the C5-methyltransferase family &  Contains 2 BAH domains &  Contains 1 CXXC-type zinc finger

uniprot_information:
SwissProt: P26358 # The N-terminal part is required for homodimerization and acts as a regulatory domain# Belongs to the C5-methyltransferase family &  Contains 2 BAH domains &  Contains 1 CXXC-type zinc finger


uniprot_information_type: SwissProt: P32942
uniprot_information:
Belongs to the immunoglobulin superfamily. ICAM family &  Contains 5 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: P29597 # The FERM domain mediates interaction with JAKMIP1# Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily &  Contains 1 FERM domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain

uniprot_information:
SwissProt: P29597 # The FERM domain mediates interaction with JAKMIP1# Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily &  Contains 1 FERM domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain


uniprot_information_type:
SwissProt: Q14145 # The Kelch repeats mediate interaction with NF2L2/NRF2, BPTF and PGAM5# Contains 1 BACK (BTB/Kelch associated) domain &  Contains 1 BTB (POZ) domain &  Contains 6 Kelch repeats

uniprot_information:
SwissProt: Q14145 # The Kelch repeats mediate interaction with NF2L2/NRF2, BPTF and PGAM5# Contains 1 BACK (BTB/Kelch associated) domain &  Contains 1 BTB (POZ) domain &  Contains 6 Kelch repeats


uniprot_information_type:
SwissProt: Q96HP0 # The DHR-2 domain may mediate some GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain

uniprot_information:
SwissProt: Q96HP0 # The DHR-2 domain may mediate some GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain


uniprot_information_type:
SwissProt: P19235 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation &  Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the type I cytokine receptor family. Type 1 subfamily &  Contains 1 fibronectin type-III domain

uniprot_information:
SwissProt: P19235 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation &  Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the type I cytokine receptor family. Type 1 subfamily &  Contains 1 fibronectin type-III domain


uniprot_information_type:
SwissProt: Q14576 # RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity)# Belongs to the RRM elav family &  Contains 3 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: Q14576 # RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity)# Belongs to the RRM elav family &  Contains 3 RRM (RNA recognition motif) domains


uniprot_information_type: SwissProt: O14787
uniprot_information:
Belongs to the importin beta family &  Contains 13 HEAT repeats &  Contains 1 importin N-terminal domain


uniprot_information_type: SwissProt: Q9Y285
uniprot_information:
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 2 subfamily


uniprot_information_type:
SwissProt: O00555 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily

uniprot_information:
SwissProt: O00555 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily


uniprot_information_type: SwissProt: Q6PEZ8
uniprot_information:
Belongs to the small leucine-rich proteoglycan (SLRP) family. Class V subfamily &  Contains 16 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: O94910 # The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin (By similarity)# Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 1 GPS domain &  Contains 1 olfactomedin-like domain &  Contains 1 SUEL-type lectin domain

uniprot_information:
SwissProt: O94910 # The extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin (By similarity)# Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 1 GPS domain &  Contains 1 olfactomedin-like domain &  Contains 1 SUEL-type lectin domain


uniprot_information_type: SwissProt: O00148
uniprot_information:
Belongs to the DEAD box helicase family. DECD subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: Q9BY15
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 2 EGF-like domains &  Contains 1 GPS domain


uniprot_information_type:
SwissProt: Q9UHX3 # The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk &  Binding to chondroitin sulfate is mediated by the fourth EGF domain# Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 5 EGF-like domains &  Contains 1 GPS domain

uniprot_information:
SwissProt: Q9UHX3 # The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk &  Binding to chondroitin sulfate is mediated by the fourth EGF domain# Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 5 EGF-like domains &  Contains 1 GPS domain


uniprot_information_type: SwissProt: Q9UM47
uniprot_information:
Belongs to the NOTCH family &  Contains 5 ANK repeats &  Contains 34 EGF-like domains &  Contains 3 LNR (Lin/Notch) repeats


uniprot_information_type:
SwissProt: O95785 # The C2H2-type zinc finger 11 mediates interaction with EHMT1 and EHMT2 (By similarity)# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 11 C2H2-type zinc fingers

uniprot_information:
SwissProt: O95785 # The C2H2-type zinc finger 11 mediates interaction with EHMT1 and EHMT2 (By similarity)# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 11 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q9UPW8 # The C2 domains are not involved in calcium-dependent phospholipid binding (By similarity) &  The C-terminal region containing both MHD domains and the third C2 domain is required for synaptic vesicle priming activity (By similarity)# Belongs to the unc-13 family &  Contains 3 C2 domains &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 MHD2 (MUNC13 homology domain 2) domain &  Contains 1 phorbol-ester/DAG-type zinc finger

uniprot_information:
SwissProt: Q9UPW8 # The C2 domains are not involved in calcium-dependent phospholipid binding (By similarity) &  The C-terminal region containing both MHD domains and the third C2 domain is required for synaptic vesicle priming activity (By similarity)# Belongs to the unc-13 family &  Contains 3 C2 domains &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 MHD2 (MUNC13 homology domain 2) domain &  Contains 1 phorbol-ester/DAG-type zinc finger


uniprot_information_type:
SwissProt: P52333 # Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1# Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily &  Contains 1 FERM domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain

uniprot_information:
SwissProt: P52333 # Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1# Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily &  Contains 1 FERM domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain


uniprot_information_type:
SwissProt: P42701 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 5 fibronectin type-III domains

uniprot_information:
SwissProt: P42701 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 5 fibronectin type-III domains


uniprot_information_type:
SwissProt: O75462 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding# Belongs to the type I cytokine receptor family. Type 3 subfamily &  Contains 2 fibronectin type-III domains &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: O75462 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding# Belongs to the type I cytokine receptor family. Type 3 subfamily &  Contains 2 fibronectin type-III domains &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: P49747 # The cell attachment motif mediates the attachment to chondrocytes. It mediates the induction of both the IAP family of survival proteins and the antiapoptotic response &  The TSP C-terminal domain mediates interaction with FN1 and ACAN# Belongs to the thrombospondin family &  Contains 4 EGF-like domains &  Contains 1 TSP C-terminal (TSPC) domain &  Contains 8 TSP type-3 repeats

uniprot_information:
SwissProt: P49747 # The cell attachment motif mediates the attachment to chondrocytes. It mediates the induction of both the IAP family of survival proteins and the antiapoptotic response &  The TSP C-terminal domain mediates interaction with FN1 and ACAN# Belongs to the thrombospondin family &  Contains 4 EGF-like domains &  Contains 1 TSP C-terminal (TSPC) domain &  Contains 8 TSP type-3 repeats


uniprot_information_type:
SwissProt: Q9NSC5 # The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3# Belongs to the Homer family &  Contains 1 WH1 domain

uniprot_information:
SwissProt: Q9NSC5 # The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3# Belongs to the Homer family &  Contains 1 WH1 domain


uniprot_information_type: SwissProt: P17038
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 22 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: O43345
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 34 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: Q05481
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 36 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q96DZ5 # Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD)# Contains 3 ANK repeats &  Contains 2 CAP-Gly domains

uniprot_information:
SwissProt: Q96DZ5 # Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD)# Contains 3 ANK repeats &  Contains 2 CAP-Gly domains


uniprot_information_type:
SwissProt: P56470 # Contains two homologous but distinct carbohydrate-binding domains# Contains 2 galectin domains

uniprot_information:
SwissProt: P56470 # Contains two homologous but distinct carbohydrate-binding domains# Contains 2 galectin domains


uniprot_information_type:
SwissProt: Q9NP81 # Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding (By similarity)# Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

uniprot_information:
SwissProt: Q9NP81 # Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding (By similarity)# Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily


uniprot_information_type:
SwissProt: Q9Y6R7 # The N-terminal IgGFc-binding region is primate-specific# Contains 12 TIL (trypsin inhibitory-like) domains &  Contains 13 VWFD domains

uniprot_information:
SwissProt: Q9Y6R7 # The N-terminal IgGFc-binding region is primate-specific# Contains 12 TIL (trypsin inhibitory-like) domains &  Contains 13 VWFD domains


uniprot_information_type: SwissProt: Q9Y6R6
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 23 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: P31751
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9BXM0 # Has a remarkable domain of repetitive pentameric units sometimes followed by a tripeptide spacer, it may separate two functional basic and acidic domains &  The Arg/Lys-rich basic domain functions as a tripartite nuclear localization signal# Belongs to the periaxin family &  Contains 1 PDZ (DHR) domain

uniprot_information:
SwissProt: Q9BXM0 # Has a remarkable domain of repetitive pentameric units sometimes followed by a tripeptide spacer, it may separate two functional basic and acidic domains &  The Arg/Lys-rich basic domain functions as a tripartite nuclear localization signal# Belongs to the periaxin family &  Contains 1 PDZ (DHR) domain


uniprot_information_type: SwissProt: O75871
uniprot_information:
Belongs to the immunoglobulin superfamily. CEA family &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: Q14002
uniprot_information:
Belongs to the immunoglobulin superfamily. CEA family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P13688
uniprot_information:
Belongs to the immunoglobulin superfamily. CEA family &  Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P31997
uniprot_information:
Belongs to the immunoglobulin superfamily. CEA family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q8WUF5 # Isoform 1 N-terminal region is required for cytoplasmic localization# Belongs to the ASPP family &  Contains 2 ANK repeats &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q8WUF5 # Isoform 1 N-terminal region is required for cytoplasmic localization# Belongs to the ASPP family &  Contains 2 ANK repeats &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: Q09013
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8IU81 # The C-terminal RING-type zinc finger domain is necessary for interaction with BAP1# Belongs to the IRF2BP family

uniprot_information:
SwissProt: Q8IU81 # The C-terminal RING-type zinc finger domain is necessary for interaction with BAP1# Belongs to the IRF2BP family


uniprot_information_type:
SwissProt: Q9UNW9 # The third KH domain (KH3) recognizes specifically 5'-UCAY-3'# Contains 3 KH domains

uniprot_information:
SwissProt: Q9UNW9 # The third KH domain (KH3) recognizes specifically 5'-UCAY-3'# Contains 3 KH domains


uniprot_information_type:
SwissProt: Q9Y314 # The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not# Belongs to the NOSIP family

uniprot_information:
SwissProt: Q9Y314 # The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not# Belongs to the NOSIP family


uniprot_information_type:
SwissProt: Q14003 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily

uniprot_information:
SwissProt: Q14003 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily


uniprot_information_type: SwissProt: Q9Y566
uniprot_information:
Belongs to the SHANK family &  Contains 6 ANK repeats &  Contains 1 PDZ (DHR) domain &  Contains 1 SAM (sterile alpha motif) domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q9NYZ4 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q9NYZ4 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: O43699 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: O43699 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: O15389 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: O15389 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: O75022 # Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 4 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: O75022 # Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 4 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: O75023 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 4 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: O75023 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 4 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q8N423 # Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 4 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: Q8N423 # Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 4 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q6GTX8 # ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, leading to down-regulation of cell activation# Contains 1 Ig-like C2-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q6GTX8 # ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, leading to down-regulation of cell activation# Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q9HD43 # The extracellular domain mediates homodimerization. One or more cysteines in the extracelllular domain is essential for the formation of dimers probably by forming a disulfide bond &  The cytoplasmic domain mediates the interaction with LCK# Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily &  Contains 8 fibronectin type-III domains &  Contains 1 tyrosine-protein phosphatase domain

uniprot_information:
SwissProt: Q9HD43 # The extracellular domain mediates homodimerization. One or more cysteines in the extracelllular domain is essential for the formation of dimers probably by forming a disulfide bond &  The cytoplasmic domain mediates the interaction with LCK# Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily &  Contains 8 fibronectin type-III domains &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type: SwissProt: Q9GZU2
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 12 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: Q8TBC5
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 2 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type:
SwissProt: O43633 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components# Belongs to the SNF7 family

uniprot_information:
SwissProt: O43633 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components# Belongs to the SNF7 family


uniprot_information_type:
SwissProt: P61081 # Both the N-terminal docking peptide and the catalytic core domain must bind the UBA3-NAE1 complex simultaneously for optimal transfer of NEDD8# Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily

uniprot_information:
SwissProt: P61081 # Both the N-terminal docking peptide and the catalytic core domain must bind the UBA3-NAE1 complex simultaneously for optimal transfer of NEDD8# Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily


uniprot_information_type: SwissProt: P28698
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 13 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type:
SwissProt: P49427 # The C-terminal acidic tail is required for nuclear localization and is involved in the binding to SCF E3 ligase complexes, and more specifically with the CUL1 subunit# Belongs to the ubiquitin-conjugating enzyme family

uniprot_information:
SwissProt: P49427 # The C-terminal acidic tail is required for nuclear localization and is involved in the binding to SCF E3 ligase complexes, and more specifically with the CUL1 subunit# Belongs to the ubiquitin-conjugating enzyme family


uniprot_information_type:
SwissProt: Q9UL51 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel HCN family &  Contains 1 cyclic nucleotide-binding domain

uniprot_information:
SwissProt: Q9UL51 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel HCN family &  Contains 1 cyclic nucleotide-binding domain


uniprot_information_type: SwissProt: O95633
uniprot_information:
Contains 2 follistatin-like domains &  Contains 2 Kazal-like domains &  Contains 1 TB (TGF-beta binding) domain


uniprot_information_type: SwissProt: Q15831
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q14011 # Both the RRM domain and the arginine, glycine (RGG) rich domain are necessary for binding to the TXN 3'-untranslated region. Both the RRM domain and the arginine, glycine (RGG) rich domain (RGG repeats) are necessary for optimal recruitment into SGs upon cellular stress. The C-terminal domain containing RGG repeats is necessary for translational repression (By similarity)# Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q14011 # Both the RRM domain and the arginine, glycine (RGG) rich domain are necessary for binding to the TXN 3'-untranslated region. Both the RRM domain and the arginine, glycine (RGG) rich domain (RGG repeats) are necessary for optimal recruitment into SGs upon cellular stress. The C-terminal domain containing RGG repeats is necessary for translational repression (By similarity)# Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: Q2TAK8 # The PWWP domain mediates the interaction with nucleosomes# Belongs to the MUM1 family &  Contains 1 PWWP domain

uniprot_information:
SwissProt: Q2TAK8 # The PWWP domain mediates the interaction with nucleosomes# Belongs to the MUM1 family &  Contains 1 PWWP domain


uniprot_information_type:
SwissProt: Q8N2W9 # The LXXLL motif is a coregulator signature that is essential for transcriptional corepression# Belongs to the PIAS family &  Contains 1 PINIT domain &  Contains 1 SAP domain &  Contains 1 SP-RING-type zinc finger

uniprot_information:
SwissProt: Q8N2W9 # The LXXLL motif is a coregulator signature that is essential for transcriptional corepression# Belongs to the PIAS family &  Contains 1 PINIT domain &  Contains 1 SAP domain &  Contains 1 SP-RING-type zinc finger


uniprot_information_type: SwissProt: Q14213
uniprot_information:
Belongs to the type I cytokine receptor family. Type 3 subfamily &  Contains 2 fibronectin type-III domains


uniprot_information_type:
SwissProt: Q9BTV5 # B30.2 box contains a microtubule-binding site# Contains 1 B30.2/SPRY domain &  Contains 1 COS domain &  Contains 1 fibronectin type-III domain

uniprot_information:
SwissProt: Q9BTV5 # B30.2 box contains a microtubule-binding site# Contains 1 B30.2/SPRY domain &  Contains 1 COS domain &  Contains 1 fibronectin type-III domain


uniprot_information_type:
SwissProt: Q13111 # Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Belongs to the CHAF1A family

uniprot_information:
SwissProt: Q13111 # Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Belongs to the CHAF1A family


uniprot_information_type:
SwissProt: O94953 # The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity)# Belongs to the JHDM3 histone demethylase family &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 2 PHD-type zinc fingers &  Contains 2 Tudor domains

uniprot_information:
SwissProt: O94953 # The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails (By similarity)# Belongs to the JHDM3 histone demethylase family &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 2 PHD-type zinc fingers &  Contains 2 Tudor domains


uniprot_information_type:
SwissProt: P15498 # The DH domain is involved in interaction with CCPG1 (By similarity)# Contains 1 CH (calponin-homology) domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 SH2 domain &  Contains 2 SH3 domains

uniprot_information:
SwissProt: P15498 # The DH domain is involved in interaction with CCPG1 (By similarity)# Contains 1 CH (calponin-homology) domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 SH2 domain &  Contains 2 SH3 domains


uniprot_information_type: SwissProt: Q14246
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 6 EGF-like domains &  Contains 1 GPS domain


uniprot_information_type: SwissProt: Q8IY17
uniprot_information:
Belongs to the NTE family &  Contains 3 cyclic nucleotide-binding domains &  Contains 1 patatin domain


uniprot_information_type:
SwissProt: Q9H2X3 # The tandem repeat domain, also called neck domain, mediates oligomerization# Contains 1 C-type lectin domain

uniprot_information:
SwissProt: Q9H2X3 # The tandem repeat domain, also called neck domain, mediates oligomerization# Contains 1 C-type lectin domain


uniprot_information_type:
SwissProt: Q9P0N8 # The RING-CH-type zinc finger domain is required for E3 ligase activity# Contains 1 RING-CH-type zinc finger

uniprot_information:
SwissProt: Q9P0N8 # The RING-CH-type zinc finger domain is required for E3 ligase activity# Contains 1 RING-CH-type zinc finger


uniprot_information_type:
SwissProt: Q13526 # The WW domain is required for the interaction with STIL and KIF20B# Contains 1 PpiC domain &  Contains 1 WW domain

uniprot_information:
SwissProt: Q13526 # The WW domain is required for the interaction with STIL and KIF20B# Contains 1 PpiC domain &  Contains 1 WW domain


uniprot_information_type: SwissProt: Q9UMF0
uniprot_information:
Belongs to the immunoglobulin superfamily. ICAM family &  Contains 9 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: P01130
uniprot_information:
Belongs to the LDLR family &  Contains 3 EGF-like domains &  Contains 7 LDL-receptor class A domains &  Contains 6 LDL-receptor class B repeats


uniprot_information_type:
SwissProt: P27797 # Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity &  The interaction with glycans occurs through a binding site in the globular lectin domain &  The zinc binding sites are localized to the N-domain &  Associates with PDIA3 through the tip of the extended arm formed by the P-domain# Belongs to the calreticulin family

uniprot_information:
SwissProt: P27797 # Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity &  The interaction with glycans occurs through a binding site in the globular lectin domain &  The zinc binding sites are localized to the N-domain &  Associates with PDIA3 through the tip of the extended arm formed by the P-domain# Belongs to the calreticulin family


uniprot_information_type:
SwissProt: P54725 # The ubiquitin-like domain mediates interaction with MJD# Belongs to the RAD23 family &  Contains 2 UBA domains &  Contains 1 ubiquitin-like domain

uniprot_information:
SwissProt: P54725 # The ubiquitin-like domain mediates interaction with MJD# Belongs to the RAD23 family &  Contains 2 UBA domains &  Contains 1 ubiquitin-like domain


uniprot_information_type:
SwissProt: Q6P1N0 # The C2 domain is required for the repression (By similarity)# Belongs to the CC2D1 family &  Contains 1 C2 domain

uniprot_information:
SwissProt: Q6P1N0 # The C2 domain is required for the repression (By similarity)# Belongs to the CC2D1 family &  Contains 1 C2 domain


uniprot_information_type:
SwissProt: Q6UWB1 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 3 fibronectin type-III domains

uniprot_information:
SwissProt: Q6UWB1 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 3 fibronectin type-III domains


uniprot_information_type:
SwissProt: P48960 # The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region &  Binding to chondroitin sulfate is mediated by the fourth EGF domain# Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 5 EGF-like domains &  Contains 1 GPS domain

uniprot_information:
SwissProt: P48960 # The first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region &  Binding to chondroitin sulfate is mediated by the fourth EGF domain# Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 5 EGF-like domains &  Contains 1 GPS domain


uniprot_information_type:
SwissProt: Q16512 # The C1 domain does not bind the diacylglycerol (DAG)# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 1 protein kinase domain &  Contains 3 REM (Hr1) repeats

uniprot_information:
SwissProt: Q16512 # The C1 domain does not bind the diacylglycerol (DAG)# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 1 protein kinase domain &  Contains 3 REM (Hr1) repeats


uniprot_information_type:
SwissProt: P67936 # The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity# Belongs to the tropomyosin family

uniprot_information:
SwissProt: P67936 # The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity# Belongs to the tropomyosin family


uniprot_information_type: SwissProt: Q13459
uniprot_information:
Contains 4 IQ domains &  Contains 1 myosin head-like domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 Ras-associating domain &  Contains 1 Rho-GAP domain


uniprot_information_type:
SwissProt: Q9NWV8 # The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes# Belongs to the MERIT40 family

uniprot_information:
SwissProt: Q9NWV8 # The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes# Belongs to the MERIT40 family


uniprot_information_type: SwissProt: O95336
uniprot_information:
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily


uniprot_information_type:
SwissProt: Q66K74 # The N-terminus of the heavy chain associates with the C-terminus of the light chain to form the heterodimer complex (By similarity). Its C-terminal part of the heavy chain interacts with ESR1# Belongs to the MAP1 family

uniprot_information:
SwissProt: Q66K74 # The N-terminus of the heavy chain associates with the C-terminus of the light chain to form the heterodimer complex (By similarity). Its C-terminal part of the heavy chain interacts with ESR1# Belongs to the MAP1 family


uniprot_information_type: SwissProt: O00459
uniprot_information:
Belongs to the PI3K p85 subunit family &  Contains 1 Rho-GAP domain &  Contains 2 SH2 domains &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: P62987
uniprot_information:
In the N-terminal section; belongs to the ubiquitin family &  In the C-terminal section; belongs to the ribosomal protein L40e family &  Contains 1 ubiquitin-like domain


uniprot_information_type:
SwissProt: Q92900 # The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family# Belongs to the DNA2/NAM7 helicase family &  Contains 1 C2H2-type zinc finger

uniprot_information:
SwissProt: Q92900 # The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family# Belongs to the DNA2/NAM7 helicase family &  Contains 1 C2H2-type zinc finger


uniprot_information_type: SwissProt: Q9Y6V7
uniprot_information:
Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: O14593 # The third ankyrin repeat is required for association with the two other RFX subunits; RFX5 and RFXAP# Contains 5 ANK repeats

uniprot_information:
SwissProt: O14593 # The third ankyrin repeat is required for association with the two other RFX subunits; RFX5 and RFXAP# Contains 5 ANK repeats


uniprot_information_type:
SwissProt: Q96S99 # PH and FYVE-type zinc finger domains are required for lysosomal location# Contains 1 FYVE-type zinc finger &  Contains 1 PH domain

uniprot_information:
SwissProt: Q96S99 # PH and FYVE-type zinc finger domains are required for lysosomal location# Contains 1 FYVE-type zinc finger &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q9BTP7 # The C-terminal region is distantly related to RuvA domain 2, a DNA-binding domain #

uniprot_information:
SwissProt: Q9BTP7 # The C-terminal region is distantly related to RuvA domain 2, a DNA-binding domain #


uniprot_information_type:
SwissProt: Q8ND56 # The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention# Belongs to the LSM14 family &  Contains 1 FFD-TFG box domain

uniprot_information:
SwissProt: Q8ND56 # The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention# Belongs to the LSM14 family &  Contains 1 FFD-TFG box domain


uniprot_information_type: SwissProt: Q07699
uniprot_information:
Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: Q86X29
uniprot_information:
Belongs to the immunoglobulin superfamily. LISCH7 family &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P20916
uniprot_information:
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 4 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: P20273 # Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 6 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: P20273 # Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 6 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q9Y2Y4 # The C-terminal zinc finger domain functions as a transcriptional transactivator (By similarity) &  The BTB (POZ) domain possesses repressor activity (By similarity)# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 3 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q9Y2Y4 # The C-terminal zinc finger domain functions as a transcriptional transactivator (By similarity) &  The BTB (POZ) domain possesses repressor activity (By similarity)# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 3 C2H2-type zinc fingers


uniprot_information_type: SwissProt: Q9UMN6
uniprot_information:
Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily &  Contains 3 A.T hook DNA-binding domains &  Contains 1 CXXC-type zinc finger &  Contains 3 PHD-type zinc fingers &  Contains 1 post-SET domain &  Contains 1 SET domain


uniprot_information_type: SwissProt: O14559
uniprot_information:
Belongs to the PX domain-containing GAP family &  Contains 1 PX (phox homology) domain &  Contains 1 Rho-GAP domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P51693 # The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis# Belongs to the APP family

uniprot_information:
SwissProt: P51693 # The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis# Belongs to the APP family


uniprot_information_type:
SwissProt: Q9BTN0 # Lacks a cytoplasmic PDZ-binding domain, which has been implicated in function of related Lrfn proteins# Belongs to the LRFN family &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 6 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q9BTN0 # Lacks a cytoplasmic PDZ-binding domain, which has been implicated in function of related Lrfn proteins# Belongs to the LRFN family &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 6 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: P04632 # The contact of the 5th EF-hand domain from each monomer allows the formation of the homodimer and also appears to mediate the contact between the large catalytic subunit and small regulatory subunit for the formation of the heterodimer (By similarity)# Contains 5 EF-hand domains

uniprot_information:
SwissProt: P04632 # The contact of the 5th EF-hand domain from each monomer allows the formation of the homodimer and also appears to mediate the contact between the large catalytic subunit and small regulatory subunit for the formation of the heterodimer (By similarity)# Contains 5 EF-hand domains


uniprot_information_type:
SwissProt: O43291 # This inhibitor contains two inhibitory domains# Contains 2 BPTI/Kunitz inhibitor domains

uniprot_information:
SwissProt: O43291 # This inhibitor contains two inhibitory domains# Contains 2 BPTI/Kunitz inhibitor domains


uniprot_information_type: SwissProt: P21817
uniprot_information:
Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR1 subfamily &  Contains 3 B30.2/SPRY domains &  Contains 5 MIR domains


uniprot_information_type:
SwissProt: Q3ZCQ8 # The FCP1 homology domain does not contain the canonical D-x-D-x-[TV] active site, suggesting that it probably does not display phosphatase activity in vivo# Belongs to the TIM50 family &  Contains 1 FCP1 homology domain

uniprot_information:
SwissProt: Q3ZCQ8 # The FCP1 homology domain does not contain the canonical D-x-D-x-[TV] active site, suggesting that it probably does not display phosphatase activity in vivo# Belongs to the TIM50 family &  Contains 1 FCP1 homology domain


uniprot_information_type:
SwissProt: Q9NYJ7 # The DSL domain is required for binding to the Notch receptor# Contains 1 DSL domain &  Contains 6 EGF-like domains

uniprot_information:
SwissProt: Q9NYJ7 # The DSL domain is required for binding to the Notch receptor# Contains 1 DSL domain &  Contains 6 EGF-like domains


uniprot_information_type: SwissProt: Q9H254
uniprot_information:
Belongs to the spectrin family &  Contains 2 CH (calponin-homology) domains &  Contains 1 PH domain &  Contains 18 spectrin repeats


uniprot_information_type: SwissProt: Q8N2S1
uniprot_information:
Belongs to the LTBP family &  Contains 16 EGF-like domains &  Contains 4 TB (TGF-beta binding) domains


uniprot_information_type:
SwissProt: Q9BUJ2 # The RGG-box domain is methylated# Contains 1 B30.2/SPRY domain &  Contains 1 SAP domain

uniprot_information:
SwissProt: Q9BUJ2 # The RGG-box domain is methylated# Contains 1 B30.2/SPRY domain &  Contains 1 SAP domain


uniprot_information_type: SwissProt: Q3KPI0
uniprot_information:
Belongs to the immunoglobulin superfamily. CEA family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P06731
uniprot_information:
Belongs to the immunoglobulin superfamily. CEA family &  Contains 7 Ig-like (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: P40198 # The cytosolic domain is involved in S100A9 interaction# Belongs to the immunoglobulin superfamily. CEA family &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: P40198 # The cytosolic domain is involved in S100A9 interaction# Belongs to the immunoglobulin superfamily. CEA family &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q92888 # The RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity &  The DH domain is involved in interaction with CCPG1 (By similarity)# Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 RGSL (RGS-like) domain

uniprot_information:
SwissProt: Q92888 # The RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity &  The DH domain is involved in interaction with CCPG1 (By similarity)# Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 RGSL (RGS-like) domain


uniprot_information_type: SwissProt: Q7Z7M0
uniprot_information:
Contains 2 CUB domains &  Contains 5 EGF-like domains &  Contains 12 Kelch repeats &  Contains 4 laminin EGF-like domains &  Contains 7 PSI domains


uniprot_information_type:
SwissProt: Q9ULV8 # The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain &  The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Contains 1 CBL N-terminal domain &  Contains 2 EF-hand-like domains &  Contains 1 RING-type zinc finger &  Contains 1 SH2 domain

uniprot_information:
SwissProt: Q9ULV8 # The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain &  The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Contains 1 CBL N-terminal domain &  Contains 2 EF-hand-like domains &  Contains 1 RING-type zinc finger &  Contains 1 SH2 domain


uniprot_information_type:
SwissProt: Q01201 # Both N- and C-terminal domains are required for transcriptional activation# Contains 1 RHD (Rel-like) domain

uniprot_information:
SwissProt: Q01201 # Both N- and C-terminal domains are required for transcriptional activation# Contains 1 RHD (Rel-like) domain


uniprot_information_type:
SwissProt: P50552 # The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization &  The WH1 domain mediates interaction with XIRP1# Belongs to the Ena/VASP family &  Contains 1 WH1 domain

uniprot_information:
SwissProt: P50552 # The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization &  The WH1 domain mediates interaction with XIRP1# Belongs to the Ena/VASP family &  Contains 1 WH1 domain


uniprot_information_type:
SwissProt: Q9NZN4 # The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity)# Contains 1 EF-hand domain &  Contains 1 EH domain

uniprot_information:
SwissProt: Q9NZN4 # The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity)# Contains 1 EF-hand domain &  Contains 1 EH domain


uniprot_information_type:
SwissProt: Q02818 # The EF-hand domains are unfolded in the absence of Ca(2+) and fold upon Ca(2+) addition# Belongs to the nucleobindin family &  Contains 2 EF-hand domains

uniprot_information:
SwissProt: Q02818 # The EF-hand domains are unfolded in the absence of Ca(2+) and fold upon Ca(2+) addition# Belongs to the nucleobindin family &  Contains 2 EF-hand domains


uniprot_information_type:
SwissProt: Q07812 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family (By similarity)# Belongs to the Bcl-2 family

uniprot_information:
SwissProt: Q07812 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family (By similarity)# Belongs to the Bcl-2 family


uniprot_information_type:
SwissProt: Q9Y230 # The C-terminal domain is required for association with ATF2# Belongs to the ruvB family

uniprot_information:
SwissProt: Q9Y230 # The C-terminal domain is required for association with ATF2# Belongs to the ruvB family


uniprot_information_type:
SwissProt: Q9HAP6 # The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane (By similarity) &  The PDZ domain regulates endocytosis and recycling of the receptor at the membrane (By similarity) &  The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes (By similarity)# Belongs to the lin-7 family &  Contains 1 L27 domain &  Contains 1 PDZ (DHR) domain

uniprot_information:
SwissProt: Q9HAP6 # The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane (By similarity) &  The PDZ domain regulates endocytosis and recycling of the receptor at the membrane (By similarity) &  The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes (By similarity)# Belongs to the lin-7 family &  Contains 1 L27 domain &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: O75145 # The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS# Belongs to the liprin family. Liprin-alpha subfamily &  Contains 3 SAM (sterile alpha motif) domains

uniprot_information:
SwissProt: O75145 # The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS# Belongs to the liprin family. Liprin-alpha subfamily &  Contains 3 SAM (sterile alpha motif) domains


uniprot_information_type:
SwissProt: Q8WTR7 # The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 20 C2H2-type zinc fingers &  Contains 1 KRAB domain

uniprot_information:
SwissProt: Q8WTR7 # The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 20 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q7Z406 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils (By similarity)# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: Q7Z406 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils (By similarity)# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type:
SwissProt: Q01892 # The protein contains a weakly acidic N-terminal transactivation domain (TAD) followed by a second TAD rich in proline, serine and threonine. Each of these domains may be required for transcriptional activation of a subset of target genes# Belongs to the ETS family &  Contains 1 ETS DNA-binding domain

uniprot_information:
SwissProt: Q01892 # The protein contains a weakly acidic N-terminal transactivation domain (TAD) followed by a second TAD rich in proline, serine and threonine. Each of these domains may be required for transcriptional activation of a subset of target genes# Belongs to the ETS family &  Contains 1 ETS DNA-binding domain


uniprot_information_type:
SwissProt: Q9Y336 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q9Y336 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q9Y286 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q9Y286 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: P20138 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: P20138 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: P30153 # Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure# Belongs to the phosphatase 2A regulatory subunit A family &  Contains 15 HEAT repeats

uniprot_information:
SwissProt: P30153 # Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure# Belongs to the phosphatase 2A regulatory subunit A family &  Contains 15 HEAT repeats


uniprot_information_type:
SwissProt: Q8WWY3 # Interacts with the snRNP via the Nop domain &  The coiled coil domain is formed by two non-contiguous helices# Belongs to the PRP31 family &  Contains 1 Nop domain

uniprot_information:
SwissProt: Q8WWY3 # Interacts with the snRNP via the Nop domain &  The coiled coil domain is formed by two non-contiguous helices# Belongs to the PRP31 family &  Contains 1 Nop domain


uniprot_information_type:
SwissProt: Q8NHJ6 # Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 2 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: Q8NHJ6 # Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 2 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: P43629
uniprot_information:
Belongs to the immunoglobulin superfamily &  Contains 3 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: O76036
uniprot_information:
Belongs to the natural cytotoxicity receptor (NCR) family &  Contains 2 Ig-like (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q9NX02 # The DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD &  When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding# Belongs to the NLRP family &  Contains 1 DAPIN domain &  Contains 9 LRR (leucine-rich) repeats &  Contains 1 NACHT domain

uniprot_information:
SwissProt: Q9NX02 # The DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD &  When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding# Belongs to the NLRP family &  Contains 1 DAPIN domain &  Contains 9 LRR (leucine-rich) repeats &  Contains 1 NACHT domain


uniprot_information_type:
SwissProt: Q9Y6I3 # The NPF repeat domain is involved in EPS15 binding &  The DPW repeat domain is involved in AP2A2 and clathrin binding &  The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction with the AP-2 complex subunit AP2B1 (By similarity)# Belongs to the epsin family &  Contains 1 ENTH (epsin N-terminal homology) domain &  Contains 2 UIM (ubiquitin-interacting motif) repeats

uniprot_information:
SwissProt: Q9Y6I3 # The NPF repeat domain is involved in EPS15 binding &  The DPW repeat domain is involved in AP2A2 and clathrin binding &  The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction with the AP-2 complex subunit AP2B1 (By similarity)# Belongs to the epsin family &  Contains 1 ENTH (epsin N-terminal homology) domain &  Contains 2 UIM (ubiquitin-interacting motif) repeats


uniprot_information_type: SwissProt: Q96GC6
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers &  Contains 2 KRAB domains &  Contains 1 SCAN box domain


uniprot_information_type:
SwissProt: Q13263 # The HP1 box is both necessary and sufficient for HP1 binding. The RING finger domain and the B-box domains mediate interaction with CEBPB. The PHD domain enhances the CEBPB transcriptional activity (By similarity) &  Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 bromo domain &  Contains 1 PHD-type zinc finger &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q13263 # The HP1 box is both necessary and sufficient for HP1 binding. The RING finger domain and the B-box domains mediate interaction with CEBPB. The PHD domain enhances the CEBPB transcriptional activity (By similarity) &  Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 bromo domain &  Contains 1 PHD-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q9P1W8
uniprot_information:
Contains 2 Ig-like C1-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: Q9BZZ2
uniprot_information:
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family &  Contains 16 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: Q9UGH3
uniprot_information:
Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily


uniprot_information_type:
SwissProt: Q9BQL6 # The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain. The FERM domain contains the subdomains F1, F2 and F3. It is preceded by a F0 domain with a ubiquitin-like fold. The F0 domain is required for integrin activation and for localization at focal adhesions# Belongs to the kindlin family &  Contains 1 FERM domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q9BQL6 # The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain. The FERM domain contains the subdomains F1, F2 and F3. It is preceded by a F0 domain with a ubiquitin-like fold. The F0 domain is required for integrin activation and for localization at focal adhesions# Belongs to the kindlin family &  Contains 1 FERM domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q9NPJ1 # The substrate-binding apical domain region is sufficient for centrosomal association# Belongs to the TCP-1 chaperonin family

uniprot_information:
SwissProt: Q9NPJ1 # The substrate-binding apical domain region is sufficient for centrosomal association# Belongs to the TCP-1 chaperonin family


uniprot_information_type: SwissProt: Q96L93
uniprot_information:
Belongs to the kinesin-like protein family &  Contains 1 FHA domain &  Contains 1 kinesin-motor domain &  Contains 1 PX (phox homology) domain


uniprot_information_type:
SwissProt: O95096 # The homeodomain is essential for interaction with OLIG2 (By similarity)# Belongs to the NK-2 homeobox family &  Contains 1 homeobox DNA-binding domain

uniprot_information:
SwissProt: O95096 # The homeodomain is essential for interaction with OLIG2 (By similarity)# Belongs to the NK-2 homeobox family &  Contains 1 homeobox DNA-binding domain


uniprot_information_type: SwissProt: Q9NZR4
uniprot_information:
Belongs to the paired homeobox family &  Contains 1 CVC domain &  Contains 1 homeobox DNA-binding domain


uniprot_information_type:
SwissProt: Q9Y2I6 # The KEN and D (destructive) boxes are required for the cell cycle-controlled NINL degradation by the APC/C pathway# Contains 4 EF-hand domains

uniprot_information:
SwissProt: Q9Y2I6 # The KEN and D (destructive) boxes are required for the cell cycle-controlled NINL degradation by the APC/C pathway# Contains 4 EF-hand domains


uniprot_information_type: SwissProt: Q9Y3M9
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 20 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q07817 # The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death# Belongs to the Bcl-2 family

uniprot_information:
SwissProt: Q07817 # The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death# Belongs to the Bcl-2 family


uniprot_information_type: SwissProt: Q96SZ6
uniprot_information:
Belongs to the methylthiotransferase family. MiaB subfamily &  Contains 1 MTTase N-terminal domain &  Contains 1 TRAM domain


uniprot_information_type:
SwissProt: Q13424 # The PH 1 domain mediates the oligomerization in a calcium dependent manner, and the association with the phosphatidylinositol 4,5-biphosphate (By similarity) &  The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity) &  The SU domain binds calmodulin in a calcium-dependent manner (By similarity)# Belongs to the syntrophin family &  Contains 1 PDZ (DHR) domain &  Contains 2 PH domains &  Contains 1 SU (syntrophin unique) domain

uniprot_information:
SwissProt: Q13424 # The PH 1 domain mediates the oligomerization in a calcium dependent manner, and the association with the phosphatidylinositol 4,5-biphosphate (By similarity) &  The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity) &  The SU domain binds calmodulin in a calcium-dependent manner (By similarity)# Belongs to the syntrophin family &  Contains 1 PDZ (DHR) domain &  Contains 2 PH domains &  Contains 1 SU (syntrophin unique) domain


uniprot_information_type:
SwissProt: Q14686 # Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Only motif 1 is essential for the association with nuclear receptors, while adjacent Ser-884 displays selectivity for nuclear receptors#

uniprot_information:
SwissProt: Q14686 # Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Only motif 1 is essential for the association with nuclear receptors, while adjacent Ser-884 displays selectivity for nuclear receptors#


uniprot_information_type:
SwissProt: Q9Y5Q3 # The leucine-zipper domain is involved in the interaction with LRPICD# Belongs to the bZIP family. Maf subfamily &  Contains 1 bZIP domain

uniprot_information:
SwissProt: Q9Y5Q3 # The leucine-zipper domain is involved in the interaction with LRPICD# Belongs to the bZIP family. Maf subfamily &  Contains 1 bZIP domain


uniprot_information_type: SwissProt: Q9H4I2
uniprot_information:
Belongs to the ZHX family &  Contains 2 C2H2-type zinc fingers &  Contains 5 homeobox DNA-binding domains


uniprot_information_type:
SwissProt: Q9BR39 # The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids (By similarity)# Belongs to the junctophilin family &  Contains 8 MORN repeats

uniprot_information:
SwissProt: Q9BR39 # The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids (By similarity)# Belongs to the junctophilin family &  Contains 8 MORN repeats


uniprot_information_type:
SwissProt: Q96KK3 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily

uniprot_information:
SwissProt: Q96KK3 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily


uniprot_information_type:
SwissProt: O95793 # One of the DRDB could be involved in RER binding &  The C-terminal contains the tubulin binding domain (TBD) (By similarity)# Contains 3 DRBM (double-stranded RNA-binding) domains

uniprot_information:
SwissProt: O95793 # One of the DRDB could be involved in RER binding &  The C-terminal contains the tubulin binding domain (TBD) (By similarity)# Contains 3 DRBM (double-stranded RNA-binding) domains


uniprot_information_type:
SwissProt: Q14721 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily

uniprot_information:
SwissProt: Q14721 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily


uniprot_information_type:
SwissProt: Q9UIX4 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily

uniprot_information:
SwissProt: Q9UIX4 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.1/KCNG1 sub-subfamily


uniprot_information_type:
SwissProt: Q969W9 # The WW-binding motifs mediate interaction with NEDD4 (By similarity)# Belongs to the PMEPA1 family

uniprot_information:
SwissProt: Q969W9 # The WW-binding motifs mediate interaction with NEDD4 (By similarity)# Belongs to the PMEPA1 family


uniprot_information_type:
SwissProt: O95685 # The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes# Contains 1 CBM21 (carbohydrate binding type-21) domain

uniprot_information:
SwissProt: O95685 # The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes# Contains 1 CBM21 (carbohydrate binding type-21) domain


uniprot_information_type:
SwissProt: O15230 # Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer# Contains 22 laminin EGF-like domains &  Contains 5 laminin G-like domains &  Contains 1 laminin IV type A domain &  Contains 1 laminin N-terminal domain

uniprot_information:
SwissProt: O15230 # Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer# Contains 22 laminin EGF-like domains &  Contains 5 laminin G-like domains &  Contains 1 laminin IV type A domain &  Contains 1 laminin N-terminal domain


uniprot_information_type: SwissProt: P43681
uniprot_information:
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily


uniprot_information_type:
SwissProt: O43526 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily

uniprot_information:
SwissProt: O43526 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily


uniprot_information_type: SwissProt: Q9BYM8
uniprot_information:
Contains 1 B box-type zinc finger &  Contains 1 RanBP2-type zinc finger &  Contains 1 RING-type zinc finger &  Contains 1 ubiquitin-like domain


uniprot_information_type: SwissProt: P18433
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily &  Contains 2 tyrosine-protein phosphatase domains


uniprot_information_type: SwissProt: O75882
uniprot_information:
Contains 1 C-type lectin domain &  Contains 1 CUB domain &  Contains 1 EGF-like domain &  Contains 6 Kelch repeats &  Contains 2 laminin EGF-like domains &  Contains 4 PSI domains


uniprot_information_type:
SwissProt: Q7Z434 # Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58 and IFIH1# Contains 1 CARD domain

uniprot_information:
SwissProt: Q7Z434 # Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58 and IFIH1# Contains 1 CARD domain


uniprot_information_type:
SwissProt: P04156 # The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization &  Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization# Belongs to the prion family

uniprot_information:
SwissProt: P04156 # The normal, monomeric form has a mainly alpha-helical structure. The disease-associated, protease-resistant form forms amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Disease mutations may favor intermolecular contacts via short beta strands, and may thereby trigger oligomerization &  Contains an N-terminal region composed of octamer repeats. At low copper concentrations, the sidechains of His residues from three or four repeats contribute to the binding of a single copper ion. Alternatively, a copper ion can be bound by interaction with the sidechain and backbone amide nitrogen of a single His residue. The observed copper binding stoichiometry suggests that two repeat regions cooperate to stabilize the binding of a single copper ion. At higher copper concentrations, each octamer can bind one copper ion by interactions with the His sidechain and Gly backbone atoms. A mixture of binding types may occur, especially in the case of octamer repeat expansion. Copper binding may stabilize the conformation of this region and may promote oligomerization# Belongs to the prion family


uniprot_information_type:
SwissProt: P08631 # The SH3 domain mediates binding to HIV-1 Nef# Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily &  Contains 1 protein kinase domain &  Contains 1 SH2 domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: P08631 # The SH3 domain mediates binding to HIV-1 Nef# Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily &  Contains 1 protein kinase domain &  Contains 1 SH2 domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q8IXJ9 # Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which may be required for an association with nuclear receptors# Belongs to the Asx family &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: Q8IXJ9 # Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which may be required for an association with nuclear receptors# Belongs to the Asx family &  Contains 1 PHD-type zinc finger


uniprot_information_type:
SwissProt: Q9UBC3 # The PWWP domain is essential for targeting to pericentric heterochromatin# Belongs to the C5-methyltransferase family &  Contains 1 ADD-type zinc finger &  Contains 1 PWWP domain

uniprot_information:
SwissProt: Q9UBC3 # The PWWP domain is essential for targeting to pericentric heterochromatin# Belongs to the C5-methyltransferase family &  Contains 1 ADD-type zinc finger &  Contains 1 PWWP domain


uniprot_information_type:
SwissProt: Q15691 # Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1# Belongs to the MAPRE family &  Contains 1 CH (calponin-homology) domain &  Contains 1 EB1 C-terminal domain

uniprot_information:
SwissProt: Q15691 # Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1# Belongs to the MAPRE family &  Contains 1 CH (calponin-homology) domain &  Contains 1 EB1 C-terminal domain


uniprot_information_type:
SwissProt: P42127 # The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin# Contains 1 agouti domain

uniprot_information:
SwissProt: P42127 # The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin# Contains 1 agouti domain


uniprot_information_type:
SwissProt: Q9Y5R2 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: Q9Y5R2 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type: SwissProt: Q9BVI0
uniprot_information:
Contains 1 A.T hook DNA-binding domain &  Contains 1 C2H2-type zinc finger &  Contains 1 PHD-type zinc finger


uniprot_information_type:
SwissProt: P17213 # The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested# Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family &  Contains 2 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: P17213 # The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested# Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family &  Contains 2 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: P19174 # The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1# Contains 1 C2 domain &  Contains 1 EF-hand domain &  Contains 2 PH domains &  Contains 1 PI-PLC X-box domain &  Contains 1 PI-PLC Y-box domain &  Contains 2 SH2 domains &  Contains 1 SH3 domain

uniprot_information:
SwissProt: P19174 # The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1# Contains 1 C2 domain &  Contains 1 EF-hand domain &  Contains 2 PH domains &  Contains 1 PI-PLC X-box domain &  Contains 1 PI-PLC Y-box domain &  Contains 2 SH2 domains &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: O76076
uniprot_information:
Belongs to the CCN family &  Contains 1 IGFBP N-terminal domain &  Contains 1 TSP type-1 domain &  Contains 1 VWFC domain


uniprot_information_type:
SwissProt: P19957 # Consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain serves as an anchor to localize elafin covalently to specific sites on extracellular matrix proteins# Contains 1 WAP domain

uniprot_information:
SwissProt: P19957 # Consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain serves as an anchor to localize elafin covalently to specific sites on extracellular matrix proteins# Contains 1 WAP domain


uniprot_information_type:
SwissProt: Q9H4Z3 # The WW domain is sufficient for direct and specific interaction with the phosphorylated CTD of RNAPII largest subunit# Contains 1 WW domain

uniprot_information:
SwissProt: Q9H4Z3 # The WW domain is sufficient for direct and specific interaction with the phosphorylated CTD of RNAPII largest subunit# Contains 1 WW domain


uniprot_information_type:
SwissProt: P14780 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 3 fibronectin type-II domains &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: P14780 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 3 fibronectin type-II domains &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: Q9Y6Q9 # Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain)# Belongs to the SRC/p160 nuclear receptor coactivator family &  Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 PAS (PER-ARNT-SIM) domain

uniprot_information:
SwissProt: Q9Y6Q9 # Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain)# Belongs to the SRC/p160 nuclear receptor coactivator family &  Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 PAS (PER-ARNT-SIM) domain


uniprot_information_type: SwissProt: Q96GQ7
uniprot_information:
Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q9BYG5 # The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases &  The PDZ domain mediates interaction with MPP5 (By similarity)# Belongs to the PAR6 family &  Contains 1 OPR domain &  Contains 1 PDZ (DHR) domain &  Contains 1 pseudo-CRIB domain

uniprot_information:
SwissProt: Q9BYG5 # The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases &  The PDZ domain mediates interaction with MPP5 (By similarity)# Belongs to the PAR6 family &  Contains 1 OPR domain &  Contains 1 PDZ (DHR) domain &  Contains 1 pseudo-CRIB domain


uniprot_information_type: SwissProt: O95396
uniprot_information:
In the N-terminal section; belongs to the hesA/moeB/thiF family. UBA4 subfamily &  Contains 1 rhodanese domain


uniprot_information_type:
SwissProt: Q9P104 # PTB domain mediates receptor interaction (By similarity)# Belongs to the DOK family. Type B subfamily &  Contains 1 IRS-type PTB domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q9P104 # PTB domain mediates receptor interaction (By similarity)# Belongs to the DOK family. Type B subfamily &  Contains 1 IRS-type PTB domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q05048 # The WD6 domain is required for interaction with BARD1. WD domains are responsible for interaction with CSTF3 &  N-terminus mediates homodimerization# Contains 6 WD repeats

uniprot_information:
SwissProt: Q05048 # The WD6 domain is required for interaction with BARD1. WD domains are responsible for interaction with CSTF3 &  N-terminus mediates homodimerization# Contains 6 WD repeats


uniprot_information_type:
SwissProt: O75177 # The MFD (multi-functional domain) domain is involved in transcription transactivation, nuclear body targeting and dimerization (By similarity)# Belongs to the SS18 family

uniprot_information:
SwissProt: O75177 # The MFD (multi-functional domain) domain is involved in transcription transactivation, nuclear body targeting and dimerization (By similarity)# Belongs to the SS18 family


uniprot_information_type:
SwissProt: Q16186 # The PH domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of K48-linked diubiquitin allows UCHL5 access to the distal subunit (By similarity)# Belongs to the ADRM1 family &  Contains 1 PH domain

uniprot_information:
SwissProt: Q16186 # The PH domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of K48-linked diubiquitin allows UCHL5 access to the distal subunit (By similarity)# Belongs to the ADRM1 family &  Contains 1 PH domain


uniprot_information_type: SwissProt: P30989
uniprot_information:
Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily


uniprot_information_type:
SwissProt: Q8N6T3 # The region downstream of Arf-GAP domain is essential to GAP activity in vivo. This region may be required for its targeting to Golgi membranes (By similarity)# Contains 1 Arf-GAP domain

uniprot_information:
SwissProt: Q8N6T3 # The region downstream of Arf-GAP domain is essential to GAP activity in vivo. This region may be required for its targeting to Golgi membranes (By similarity)# Contains 1 Arf-GAP domain


uniprot_information_type:
SwissProt: Q01538 # Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence# Contains 7 C2HC-type zinc fingers

uniprot_information:
SwissProt: Q01538 # Contains 7 zinc fingers of the C2HC class arranged in two widely separated clusters. These two domains of DNA binding can function independently and recognize the same DNA sequence# Contains 7 C2HC-type zinc fingers


uniprot_information_type:
SwissProt: P48552 # Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The C-terminal LTKTNPILYYMLQK motif is required for ligand-dependent interaction with RAAR and RXRB homo- and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB (By similarity). Contains at least four autonomous repression domains (RD1-4). RD1 functions via a histone deacetylase (HDAC)-independent mechanism, whereas RD2, RD3 and RD4 can function by HDAC-dependent or independent mechanisms, depending on cell type. RD2 is dependent on CTBP binding#

uniprot_information:
SwissProt: P48552 # Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The C-terminal LTKTNPILYYMLQK motif is required for ligand-dependent interaction with RAAR and RXRB homo- and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB (By similarity). Contains at least four autonomous repression domains (RD1-4). RD1 functions via a histone deacetylase (HDAC)-independent mechanism, whereas RD2, RD3 and RD4 can function by HDAC-dependent or independent mechanisms, depending on cell type. RD2 is dependent on CTBP binding#


uniprot_information_type: SwissProt: P98073
uniprot_information:
Belongs to the peptidase S1 family &  Contains 2 CUB domains &  Contains 2 LDL-receptor class A domains &  Contains 1 MAM domain &  Contains 1 peptidase S1 domain &  Contains 1 SEA domain &  Contains 1 SRCR domain


uniprot_information_type:
SwissProt: P05067 # The basolateral sorting signal (BaSS) is required for sorting of membrane proteins to the basolateral surface of epithelial cells &  The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The PID domain-containing proteins which bind APP require the YENPTY motif for full interaction. These interactions are independent of phosphorylation on the terminal tyrosine residue. The NPXY site is also involved in clathrin-mediated endocytosis# Belongs to the APP family &  Contains 1 BPTI/Kunitz inhibitor domain

uniprot_information:
SwissProt: P05067 # The basolateral sorting signal (BaSS) is required for sorting of membrane proteins to the basolateral surface of epithelial cells &  The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The PID domain-containing proteins which bind APP require the YENPTY motif for full interaction. These interactions are independent of phosphorylation on the terminal tyrosine residue. The NPXY site is also involved in clathrin-mediated endocytosis# Belongs to the APP family &  Contains 1 BPTI/Kunitz inhibitor domain


uniprot_information_type:
SwissProt: Q9UHI8 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 3 TSP type-1 domains

uniprot_information:
SwissProt: Q9UHI8 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 3 TSP type-1 domains


uniprot_information_type:
SwissProt: Q9UNA0 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 2 TSP type-1 domains

uniprot_information:
SwissProt: Q9UNA0 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 2 TSP type-1 domains


uniprot_information_type: SwissProt: Q13009
uniprot_information:
Belongs to the TIAM family &  Contains 1 DH (DBL-homology) domain &  Contains 1 PDZ (DHR) domain &  Contains 2 PH domains &  Contains 1 RBD (Ras-binding) domain


uniprot_information_type: SwissProt: O95104
uniprot_information:
Belongs to the splicing factor SR family &  Contains 1 CID domain &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: O43426 # Binds to EPS15 (a clathrin coat-associated protein) via a C-terminal domain containing three Asn-Pro-Phe (NPF) repeats (By similarity) &  The C-terminal proline-rich region mediates binding to a variety of SH3 domain-containing proteins including AMPH, SH3GL1, SH3GL2, SH3GL3 and GRB2# Belongs to the synaptojanin family &  In the central section; belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family &  Contains 1 RRM (RNA recognition motif) domain &  Contains 1 SAC domain

uniprot_information:
SwissProt: O43426 # Binds to EPS15 (a clathrin coat-associated protein) via a C-terminal domain containing three Asn-Pro-Phe (NPF) repeats (By similarity) &  The C-terminal proline-rich region mediates binding to a variety of SH3 domain-containing proteins including AMPH, SH3GL1, SH3GL2, SH3GL3 and GRB2# Belongs to the synaptojanin family &  In the central section; belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family &  Contains 1 RRM (RNA recognition motif) domain &  Contains 1 SAC domain


uniprot_information_type: SwissProt: P22102
uniprot_information:
In the N-terminal section; belongs to the GARS family &  In the central section; belongs to the AIR synthase family &  In the C-terminal section; belongs to the GART family &  Contains 1 ATP-grasp domain


uniprot_information_type:
SwissProt: Q01196 # A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes# Contains 1 Runt domain

uniprot_information:
SwissProt: Q01196 # A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes# Contains 1 Runt domain


uniprot_information_type:
SwissProt: O60469 # Ig-like C2-type domains 7 to 9 are sufficient for interaction with NTN1 and commissural axon outgrowth. The transmembrane domain is necessary for interaction with DCC (By similarity)# Contains 6 fibronectin type-III domains &  Contains 10 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: O60469 # Ig-like C2-type domains 7 to 9 are sufficient for interaction with NTN1 and commissural axon outgrowth. The transmembrane domain is necessary for interaction with DCC (By similarity)# Contains 6 fibronectin type-III domains &  Contains 10 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: P57078
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 10 ANK repeats &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q01081 # The C-terminal SR-rich domain is required for interactions with SR proteins and the splicing regulators TRA and TRA2, and the N-terminal domain is required for formation of the U2AF1/U2AF2 heterodimer# Belongs to the splicing factor SR family &  Contains 2 C3H1-type zinc fingers &  Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q01081 # The C-terminal SR-rich domain is required for interactions with SR proteins and the splicing regulators TRA and TRA2, and the N-terminal domain is required for formation of the U2AF1/U2AF2 heterodimer# Belongs to the splicing factor SR family &  Contains 2 C3H1-type zinc fingers &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type: SwissProt: O95954
uniprot_information:
In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family &  In the N-terminal section; belongs to the formiminotransferase family


uniprot_information_type: SwissProt: Q9UHP3
uniprot_information:
Belongs to the peptidase C19 family &  Contains 1 UBA-like domain &  Contains 2 UIM (ubiquitin-interacting motif) repeats


uniprot_information_type:
SwissProt: P78310 # The Ig-like C2-type 1 domain probably mediates homodimerization and interaction with JAML &  The PDZ-binding motif mediates interaction with MPDZ and BAIAP1# Contains 2 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: P78310 # The Ig-like C2-type 1 domain probably mediates homodimerization and interaction with JAML &  The PDZ-binding motif mediates interaction with MPDZ and BAIAP1# Contains 2 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q9Y5T5 # The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin# Belongs to the peptidase C19 family. USP16 subfamily &  Contains 1 UBP-type zinc finger

uniprot_information:
SwissProt: Q9Y5T5 # The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin# Belongs to the peptidase C19 family. USP16 subfamily &  Contains 1 UBP-type zinc finger


uniprot_information_type:
SwissProt: Q13516 # The bHLH is essential for interaction with NKX2-2 (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain

uniprot_information:
SwissProt: Q13516 # The bHLH is essential for interaction with NKX2-2 (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain


uniprot_information_type:
SwissProt: P18583 # Contains 8 types of repeats which are distributed in 3 regions# Contains 1 DRBM (double-stranded RNA-binding) domain &  Contains 1 G-patch domain

uniprot_information:
SwissProt: P18583 # Contains 8 types of repeats which are distributed in 3 regions# Contains 1 DRBM (double-stranded RNA-binding) domain &  Contains 1 G-patch domain


uniprot_information_type:
SwissProt: Q15811 # SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin (By similarity). SH3-1 and SH3-4 bind to ARHGAP31 &  The KLERQ domain binds to SNAP-25 and SNAP-23 (By similarity)# Contains 1 C2 domain &  Contains 1 DH (DBL-homology) domain &  Contains 2 EF-hand domains &  Contains 2 EH domains &  Contains 1 PH domain &  Contains 5 SH3 domains

uniprot_information:
SwissProt: Q15811 # SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin (By similarity). SH3-1 and SH3-4 bind to ARHGAP31 &  The KLERQ domain binds to SNAP-25 and SNAP-23 (By similarity)# Contains 1 C2 domain &  Contains 1 DH (DBL-homology) domain &  Contains 2 EF-hand domains &  Contains 2 EH domains &  Contains 1 PH domain &  Contains 5 SH3 domains


uniprot_information_type:
SwissProt: P57055 # The ripply homology domain is required for transcriptional repression (By similarity) &  The WRPW motif is required for binding to tle/groucho proteins (By similarity)# Belongs to the ripply family

uniprot_information:
SwissProt: P57055 # The ripply homology domain is required for transcriptional repression (By similarity) &  The WRPW motif is required for binding to tle/groucho proteins (By similarity)# Belongs to the ripply family


uniprot_information_type:
SwissProt: O76083 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain# Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily

uniprot_information:
SwissProt: O76083 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain# Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily


uniprot_information_type:
SwissProt: Q9NRZ7 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

uniprot_information:
SwissProt: Q9NRZ7 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


uniprot_information_type:
SwissProt: O43918 # The L-X-X-L-L repeats may be implicated in binding to nuclear receptors &  The HSR domain is required for localization on tubular structures (N-terminal part) and for homodimerization &  Interacts via the first PHD domain with the N-terminus of histone H3 that is not methylated at 'Lys-4'. Disruption of the first PHD domain has been shown to lead to reduced transcriptional activity and to localization of the protein mainly in the cytoplasm in small granules. While the PHD zinc fingers are necessary for the transactivation capacity of the protein, other regions also modulate this function# Contains 1 HSR domain &  Contains 2 PHD-type zinc fingers &  Contains 1 SAND domain

uniprot_information:
SwissProt: O43918 # The L-X-X-L-L repeats may be implicated in binding to nuclear receptors &  The HSR domain is required for localization on tubular structures (N-terminal part) and for homodimerization &  Interacts via the first PHD domain with the N-terminus of histone H3 that is not methylated at 'Lys-4'. Disruption of the first PHD domain has been shown to lead to reduced transcriptional activity and to localization of the protein mainly in the cytoplasm in small granules. While the PHD zinc fingers are necessary for the transactivation capacity of the protein, other regions also modulate this function# Contains 1 HSR domain &  Contains 2 PHD-type zinc fingers &  Contains 1 SAND domain


uniprot_information_type: SwissProt: O94759
uniprot_information:
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily &  Contains 1 nudix hydrolase domain


uniprot_information_type: SwissProt: P39060
uniprot_information:
Belongs to the multiplexin collagen family &  Contains 1 FZ (frizzled) domain &  Contains 1 TSP N-terminal (TSPN) domain


uniprot_information_type:
SwissProt: O95613 # Composed of a coiled-coil central region flanked by non-helical N- and C-terminals#

uniprot_information:
SwissProt: O95613 # Composed of a coiled-coil central region flanked by non-helical N- and C-terminals#


uniprot_information_type:
SwissProt: P55957 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family#

uniprot_information:
SwissProt: P55957 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family#


uniprot_information_type:
SwissProt: P53675 # The C-terminal third of the heavy chains forms the hub of the triskelion. This region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice# Belongs to the clathrin heavy chain family

uniprot_information:
SwissProt: P53675 # The C-terminal third of the heavy chains forms the hub of the triskelion. This region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice# Belongs to the clathrin heavy chain family


uniprot_information_type:
SwissProt: P28482 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P28482 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P53674 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains

uniprot_information:
SwissProt: P53674 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains


uniprot_information_type: SwissProt: O96017
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily &  Contains 1 FHA domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9HBE1
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 A.T hook DNA-binding domain &  Contains 1 BTB (POZ) domain &  Contains 7 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: P35579 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: P35579 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type:
SwissProt: Q16762 # The structure consists of 2 domains of very similar conformation, suggesting a common evolutionary origin. However, the sequences of the 2 domains are very different# Contains 2 rhodanese domains

uniprot_information:
SwissProt: Q16762 # The structure consists of 2 domains of very similar conformation, suggesting a common evolutionary origin. However, the sequences of the 2 domains are very different# Contains 2 rhodanese domains


uniprot_information_type:
SwissProt: Q8IU80 # Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s) (By similarity)# Belongs to the peptidase S1 family &  Contains 2 CUB domains &  Contains 3 LDL-receptor class A domains &  Contains 1 peptidase S1 domain

uniprot_information:
SwissProt: Q8IU80 # Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s) (By similarity)# Belongs to the peptidase S1 family &  Contains 2 CUB domains &  Contains 3 LDL-receptor class A domains &  Contains 1 peptidase S1 domain


uniprot_information_type:
SwissProt: P14784 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 4 subfamily &  Contains 1 fibronectin type-III domain

uniprot_information:
SwissProt: P14784 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 4 subfamily &  Contains 1 fibronectin type-III domain


uniprot_information_type:
SwissProt: P48050 # The Val/Gly/Ala/Pro stretch may have a functional role in the conductance or permeation properties# Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily

uniprot_information:
SwissProt: P48050 # The Val/Gly/Ala/Pro stretch may have a functional role in the conductance or permeation properties# Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily


uniprot_information_type:
SwissProt: Q969V6 # The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity (By similarity)# Contains 2 RPEL repeats &  Contains 1 SAP domain

uniprot_information:
SwissProt: Q969V6 # The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity (By similarity)# Contains 2 RPEL repeats &  Contains 1 SAP domain


uniprot_information_type:
SwissProt: O43808 # Lacks a typical peroxisomal sorting signal# Belongs to the mitochondrial carrier family &  Contains 3 Solcar repeats

uniprot_information:
SwissProt: O43808 # Lacks a typical peroxisomal sorting signal# Belongs to the mitochondrial carrier family &  Contains 3 Solcar repeats


uniprot_information_type:
SwissProt: Q9UGU0 # The atypical PHD domain functions as a negative modulator of cofactor binding (By similarity)# Contains 1 A.T hook DNA-binding domain &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: Q9UGU0 # The atypical PHD domain functions as a negative modulator of cofactor binding (By similarity)# Contains 1 A.T hook DNA-binding domain &  Contains 1 PHD-type zinc finger


uniprot_information_type:
SwissProt: Q9NPC4 # The conserved DXD motif is involved in enzyme activity (By similarity)# Belongs to the glycosyltransferase 32 family

uniprot_information:
SwissProt: Q9NPC4 # The conserved DXD motif is involved in enzyme activity (By similarity)# Belongs to the glycosyltransferase 32 family


uniprot_information_type:
SwissProt: P53778 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P53778 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q15759 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q15759 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O95248
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily &  Contains 1 dDENN domain &  Contains 1 DENN domain &  Contains 1 GRAM domain &  Contains 1 myotubularin phosphatase domain &  Contains 1 PH domain &  Contains 1 uDENN domain


uniprot_information_type:
SwissProt: Q8WYQ5 # Both DRBM domains are required for efficient binding to pri-miRNA. The region between residues 276 and 498 has an autoinhibitory function on pri-miRNA processing activity# Contains 2 DRBM (double-stranded RNA-binding) domains &  Contains 1 WW domain

uniprot_information:
SwissProt: Q8WYQ5 # Both DRBM domains are required for efficient binding to pri-miRNA. The region between residues 276 and 498 has an autoinhibitory function on pri-miRNA processing activity# Contains 2 DRBM (double-stranded RNA-binding) domains &  Contains 1 WW domain


uniprot_information_type:
SwissProt: P05546 # The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition# Belongs to the serpin family

uniprot_information:
SwissProt: P05546 # The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition# Belongs to the serpin family


uniprot_information_type: SwissProt: Q13356
uniprot_information:
Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily &  Contains 1 PPIase cyclophilin-type domain &  Contains 1 U-box domain


uniprot_information_type:
SwissProt: P11274 # The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene &  The DH domain is involved in interaction with CCPG1 (By similarity)# Contains 1 C2 domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 Rho-GAP domain

uniprot_information:
SwissProt: P11274 # The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene &  The DH domain is involved in interaction with CCPG1 (By similarity)# Contains 1 C2 domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 Rho-GAP domain


uniprot_information_type:
SwissProt: P24347 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: P24347 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: P29274 # The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface# Belongs to the G-protein coupled receptor 1 family

uniprot_information:
SwissProt: P29274 # The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface# Belongs to the G-protein coupled receptor 1 family


uniprot_information_type:
SwissProt: P26998 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains

uniprot_information:
SwissProt: P26998 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains


uniprot_information_type:
SwissProt: P43320 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains

uniprot_information:
SwissProt: P43320 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains


uniprot_information_type:
SwissProt: P53673 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains

uniprot_information:
SwissProt: P53673 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains


uniprot_information_type:
SwissProt: Q01844 # EWS activation domain (EAD) functions as a potent activation domain in EFPS. EWSR1 binds POLR2C but not POLR2E or POLR2G, whereas the isolated EAD binds POLR2E and POLR2G but not POLR2C. Cis-linked RNA-binding domain (RBD) can strongly and specifically repress trans-activation by the EAD# Belongs to the RRM TET family &  Contains 1 IQ domain &  Contains 1 RanBP2-type zinc finger &  Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q01844 # EWS activation domain (EAD) functions as a potent activation domain in EFPS. EWSR1 binds POLR2C but not POLR2E or POLR2G, whereas the isolated EAD binds POLR2E and POLR2G but not POLR2C. Cis-linked RNA-binding domain (RBD) can strongly and specifically repress trans-activation by the EAD# Belongs to the RRM TET family &  Contains 1 IQ domain &  Contains 1 RanBP2-type zinc finger &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: Q15735 # The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein# Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family

uniprot_information:
SwissProt: Q15735 # The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein# Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family


uniprot_information_type:
SwissProt: Q9Y295 # Its C-terminal domain interacts with TAL1 (By similarity)# Belongs to the GTP1/OBG family

uniprot_information:
SwissProt: Q9Y295 # Its C-terminal domain interacts with TAL1 (By similarity)# Belongs to the GTP1/OBG family


uniprot_information_type:
SwissProt: A8K8P3 # CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for interaction with CETN2# Belongs to the SFI1 family &  Contains 6 HAT repeats

uniprot_information:
SwissProt: A8K8P3 # CETN2-binding regions contains a conserved Trp residue in their C-terminal ends, which seems critical for interaction with CETN2# Belongs to the SFI1 family &  Contains 6 HAT repeats


uniprot_information_type:
SwissProt: P32927 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 4 subfamily &  Contains 2 fibronectin type-III domains

uniprot_information:
SwissProt: P32927 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 4 subfamily &  Contains 2 fibronectin type-III domains


uniprot_information_type:
SwissProt: P25325 # The structure consists of 2 domains of very similar conformation, suggesting a common evolutionary origin. However, the sequences of the 2 domains are very different# Contains 2 rhodanese domains

uniprot_information:
SwissProt: P25325 # The structure consists of 2 domains of very similar conformation, suggesting a common evolutionary origin. However, the sequences of the 2 domains are very different# Contains 2 rhodanese domains


uniprot_information_type:
SwissProt: Q00587 # The CRIB domain mediates interaction with CDC42# Belongs to the BORG/CEP family &  Contains 1 CRIB domain

uniprot_information:
SwissProt: Q00587 # The CRIB domain mediates interaction with CDC42# Belongs to the BORG/CEP family &  Contains 1 CRIB domain


uniprot_information_type:
SwissProt: Q9UJY5 # The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif) &  The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis &  The unstructured hinge region contains clathrin-binding but no autoinhibitory (AC-LL) motifs &  The GAE domain binds accessory proteins regulating GGAs function# Belongs to the GGA protein family &  Contains 1 GAE domain &  Contains 1 GAT domain &  Contains 1 VHS domain

uniprot_information:
SwissProt: Q9UJY5 # The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif) &  The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis &  The unstructured hinge region contains clathrin-binding but no autoinhibitory (AC-LL) motifs &  The GAE domain binds accessory proteins regulating GGAs function# Belongs to the GGA protein family &  Contains 1 GAE domain &  Contains 1 GAT domain &  Contains 1 VHS domain


uniprot_information_type:
SwissProt: Q9H2D6 # Contains at least 2 actin-binding sites per coiled-coil dimer# Contains 1 PH domain

uniprot_information:
SwissProt: Q9H2D6 # Contains at least 2 actin-binding sites per coiled-coil dimer# Contains 1 PH domain


uniprot_information_type:
SwissProt: Q9NS69 # Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins# Belongs to the Tom22 family

uniprot_information:
SwissProt: Q9NS69 # Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins# Belongs to the Tom22 family


uniprot_information_type:
SwissProt: Q9P0X4 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1I subfamily

uniprot_information:
SwissProt: Q9P0X4 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1I subfamily


uniprot_information_type: SwissProt: Q96HU1
uniprot_information:
Belongs to the small G protein signaling modulator family &  Contains 1 Rab-GAP TBC domain &  Contains 1 RUN domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: Q09472
uniprot_information:
Contains 1 bromo domain &  Contains 1 KIX domain &  Contains 2 TAZ-type zinc fingers &  Contains 1 ZZ-type zinc finger


uniprot_information_type:
SwissProt: Q13323 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family#

uniprot_information:
SwissProt: Q13323 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family#


uniprot_information_type:
SwissProt: Q9Y512 # Its C-terminal part seems to contain many membrane-spanning sided beta-sheets, that have the potential to adopt a transmembrane beta-barrel type structure (By similarity)# Belongs to the SAM50/omp85 family

uniprot_information:
SwissProt: Q9Y512 # Its C-terminal part seems to contain many membrane-spanning sided beta-sheets, that have the potential to adopt a transmembrane beta-barrel type structure (By similarity)# Belongs to the SAM50/omp85 family


uniprot_information_type: SwissProt: P23142
uniprot_information:
Belongs to the fibulin family &  Contains 3 anaphylatoxin-like domains &  Contains 9 EGF-like domains


