# gene_info

symbol: SLC35D1
gene_name:
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1


symbol: ST6GALNAC5
gene_name:
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5


symbol: SEMA4A
gene_name:
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


symbol: PPFIA4
gene_name:
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4


symbol: HADHA
gene_name:
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit


symbol: SRD5A2
gene_name:
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)


symbol: SEMA4C
gene_name:
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C


symbol: ERCC3
gene_name:
excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)


symbol: HADHB
gene_name:
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit


symbol: SLC3A1
gene_name:
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1


symbol: MTHFD2
gene_name:
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase


symbol: SEMA4F
gene_name:
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F


symbol: XRCC5
gene_name:
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)


symbol: IL12A
gene_name:
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)


symbol: PAICS
gene_name:
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase


symbol: SEMA5A
gene_name:
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A


symbol: IL12B
gene_name:
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)


symbol: SRD5A1
gene_name:
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)


symbol: CMAH
gene_name:
cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMP-N-acetylneuraminate monooxygenase) pseudogene


symbol: LOC442233
gene_name:
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 pseudogene


symbol: SEMA4D
gene_name:
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D


symbol: ST6GALNAC4
gene_name:
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4


symbol: ABO
gene_name:
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)


symbol: SLC1A1
gene_name:
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1


symbol: AMMECR1
gene_name:
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1


symbol: OGT
gene_name:
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)


symbol: AKR1C2
gene_name:
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)


symbol: AKR1C4
gene_name:
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)


symbol: BTAF1
gene_name:
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)


symbol: SEMA4G
gene_name:
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G


symbol: PRKRIR
gene_name:
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)


symbol: DPAGT1
gene_name:
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)


symbol: MS4A2
gene_name:
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)


symbol: PPFIA1
gene_name:
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1


symbol: PPFIA2
gene_name:
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2


symbol: FLT1
gene_name:
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)


symbol: ALG5
gene_name:
asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae)


symbol: MTHFD1
gene_name:
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase


symbol: TIMM16
gene_name:
mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction


symbol: ITGAL
gene_name:
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)


symbol: SLC4A1
gene_name:
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)


symbol: ST6GALNAC2
gene_name:
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2


symbol: SERPINF2
gene_name:
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2


symbol: SERPINF1
gene_name:
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1


symbol: ERBB2
gene_name:
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)


symbol: GNAL
gene_name:
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type


symbol: ERCC1
gene_name:
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)


symbol: PPFIA3
gene_name:
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3


symbol: MLLT10L
gene_name:
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10-like


symbol: GART
gene_name:
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase


symbol: PKDREJ
gene_name:
polycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)


# alias

alias_symbol:
tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)


alias_symbol:
solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive)


alias_symbol:
solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive)


alias_symbol:
Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex


alias_symbol:
dihydrolipoamide branched chain transacylase (E2 component of branched chain keto acid dehydrogenase complex; maple syrup urine disease)


alias_symbol:
lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial


alias_symbol:
dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex


alias_symbol:
lipoamide acyltransferase component of mitochondrial branched-chain alpha-keto acid dehydrogenase complex


alias_symbol:
S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)


alias_symbol:
S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)


alias_symbol:
calcium channel, L type, alpha 1 polypeptide, isoform 3 (skeletal muscle, hypokalemic periodic paralysis)


alias_symbol:
endometrial bleeding associated factor (left-right determination, factor A; transforming growth factor beta superfamily)


alias_symbol:
procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase, Ehlers-Danlos syndrome type VI)


alias_symbol:
MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor


alias_symbol:
sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) E


alias_symbol:
alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase E


alias_symbol:
sialyltransferase 7 (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) E


alias_symbol:
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9 (RNA helicase A, nuclear DNA helicase II; leukophysin)


alias_symbol:
laminin, gamma 2 (nicein (100kD), kalinin (105kD), BM600 (100kD), Herlitz junctional epidermolysis bullosa))


alias_symbol:
proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome)


alias_symbol:
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit


alias_symbol:
protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)


alias_symbol:
protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)


alias_symbol:
rat regenerating islet-derived-like, human homolog (pancreatic stone protein-like, pancreatic thread protein-like)


alias_symbol:
regenerating islet-derived-like, pancreatic stone protein-like, pancreatic thread protein-like (rat)


alias_symbol:
serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2


alias_symbol:
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit


alias_symbol:
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kD)


alias_symbol:
cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1


alias_symbol:
nuclear protein, marker for differentiated aortic smooth muscle and down-regulated with vascular injury


alias_symbol:
protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), beta isoform


alias_symbol:
low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)


alias_symbol:
small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide 78)


alias_symbol:
CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II)


alias_symbol:
DNA directed RNA polymerase II 140 kDa polypeptide, RNA polymerase II subunit 2, RNA polymerase II second largest subunit


alias_symbol:
sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)


alias_symbol:
annexin III (lipocortin III, 1,2-cyclic-inositol-phosphate phosphodiesterase, placental anticoagulant protein III, calcimedin 35-alpha)


alias_symbol:
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)


alias_symbol:
extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1


alias_symbol:
Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1


alias_symbol:
Calcipressin 2 (Thyroid hormone-responsive protein ZAKI-4) (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin interacting protein 2) (MCIP2)


alias_symbol:
dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa


alias_symbol:
interaction protein for cytohesin exchange factors 1 Interaction protein for cytohesin exchange factors 1


alias_symbol:
Zinc finger protein 40 (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex binding protein 1) (MBP-1) (Positive regulatory domain II binding factor 1) (PRDII-BF1)


alias_symbol:
Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3)


alias_symbol:
protein phosphatase 1, regulatory (inhibitor) subunit 3A (glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle)


alias_symbol:
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3, isoform 1


alias_symbol:
tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)


alias_symbol:
serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1


alias_symbol:
dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex)


alias_symbol:
E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex


alias_symbol:
clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)


alias_symbol:
Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase


alias_symbol:
glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase


alias_symbol:
receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase


alias_symbol:
sialyltransferase 7D ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase)


alias_symbol:
alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase


alias_symbol:
dystrophin (muscular dystrophy, Duchenne and Becker types), includes DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272


alias_symbol:
phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)


alias_symbol:
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)


alias_symbol:
6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)


alias_symbol:
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)


alias_symbol:
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN


alias_symbol:
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170 kD (Mot1 homolog, S. cerevisiae)


alias_symbol:
SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase (yeast)


alias_symbol:
nuclear speckle targeted phosphatidylinositol 4-phosphate 5-kinase type I-alpha regulated-poly(A) polymerase


alias_symbol:
v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65))


alias_symbol:
v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65


alias_symbol:
aristaless (Drosophila) homeobox, aristaless homeobox (Drosophila), fibrosis of extraocular muscles, congenital, 2, autosomal recessive


alias_symbol:
asparagine-linked glycosylation 9, alpha- 1,2-mannosyltransferase homolog (S. cerevisiae, alpha- 1,2-mannosyltransferase)


alias_symbol:
kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))


alias_symbol:
serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)


alias_symbol:
High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain)


alias_symbol:
serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)


alias_symbol:
serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2, (collagen-binding protein 2)


alias_symbol:
dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial


alias_symbol:
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 2 (activation-induced)


alias_symbol:
UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase (GalNAc-T)


alias_symbol:
sodium/chloride dependent neurotransmitter transporter Homo sapiens orphan neurotransmitter transporter NTT7


alias_symbol:
asparagine-linked glycosylation 5 homolog (S. cerevisiae, dolichyl-phosphate beta-glucosyltransferase)


alias_symbol:
Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3)


alias_symbol:
5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase


alias_symbol:
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial


alias_symbol:
reticulocalbin 2, EF-hand calcium binding domain (endoplasmic reticulum calcium-binding protein, 55kD)


alias_symbol:
feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog


alias_symbol:
integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide)


alias_symbol:
homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein


alias_symbol:
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 14 (macrophage-derived)


alias_symbol:
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 13 (macrophage-derived)


alias_symbol:
membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)


alias_symbol:
sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) B


alias_symbol:
sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase)


alias_symbol:
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase


alias_symbol:
micromelic dwarfism with vertebral and metaphyseal abnormalities and advanced carpotarsal ossification


alias_symbol:
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55)


alias_symbol:
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase-associated 1)


alias_symbol:
serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2


alias_symbol:
serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1


alias_symbol:
TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)


alias_symbol:
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)


alias_symbol:
ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD)


alias_symbol:
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non-cardiac muscle-like 2


alias_symbol:
guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide, olfactory type


alias_symbol:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related


alias_symbol:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E, member 1-related


alias_symbol:
v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)


alias_symbol:
v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3


alias_symbol:
myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 10-like


alias_symbol:
dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4))


alias_symbol:
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)


alias_symbol:
integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)


alias_symbol:
cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2


alias_symbol:
cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2


alias_symbol:
polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly homolog, sea urchin)-like


alias_symbol:
polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly, sea urchin homolog)-like


alias_symbol:
interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity)


# uniprot

uniprot_information_type:
SwissProt: Q5TA45 # The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex (By similarity)# Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily

uniprot_information:
SwissProt: Q5TA45 # The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex (By similarity)# Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily


uniprot_information_type: SwissProt: O14640
uniprot_information:
Belongs to the DSH family &  Contains 1 DEP domain &  Contains 1 DIX domain &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: Q96S94 # Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity)# Belongs to the cyclin family. Cyclin L subfamily

uniprot_information:
SwissProt: Q96S94 # Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity)# Belongs to the cyclin family. Cyclin L subfamily


uniprot_information_type: SwissProt: Q9UQ88
uniprot_information:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q8TDI0
uniprot_information:
Belongs to the SNF2/RAD54 helicase family &  Contains 2 chromo domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 2 PHD-type zinc fingers


uniprot_information_type:
SwissProt: Q9Y543 # Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) &  The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain

uniprot_information:
SwissProt: Q9Y543 # Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) &  The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain


uniprot_information_type: SwissProt: Q9UJP4
uniprot_information:
Contains 1 BACK (BTB/Kelch associated) domain &  Contains 1 BTB (POZ) domain &  Contains 6 Kelch repeats


uniprot_information_type:
SwissProt: Q9P2R6 # The interaction with ATN1 is mediated by the coiled coil domain# Contains 1 BAH domain &  Contains 1 ELM2 domain &  Contains 1 GATA-type zinc finger &  Contains 1 SANT domain

uniprot_information:
SwissProt: Q9P2R6 # The interaction with ATN1 is mediated by the coiled coil domain# Contains 1 BAH domain &  Contains 1 ELM2 domain &  Contains 1 GATA-type zinc finger &  Contains 1 SANT domain


uniprot_information_type: SwissProt: P22732
uniprot_information:
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily


uniprot_information_type:
SwissProt: O94985 # The cytoplasmic domain is involved in interaction with APBA2, as well as the binding of synaptic Ca(2+) (By similarity)# Contains 2 cadherin domains

uniprot_information:
SwissProt: O94985 # The cytoplasmic domain is involved in interaction with APBA2, as well as the binding of synaptic Ca(2+) (By similarity)# Contains 2 cadherin domains


uniprot_information_type: SwissProt: O00187
uniprot_information:
Belongs to the peptidase S1 family &  Contains 2 CUB domains &  Contains 1 EGF-like domain &  Contains 1 peptidase S1 domain &  Contains 2 Sushi (CCP/SCR) domains


uniprot_information_type: SwissProt: P42345
uniprot_information:
Belongs to the PI3/PI4-kinase family &  Contains 1 FAT domain &  Contains 1 FATC domain &  Contains 7 HEAT repeats &  Contains 1 PI3K/PI4K domain


uniprot_information_type: SwissProt: Q13105
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 13 C2H2-type zinc fingers


uniprot_information_type: SwissProt: P29317
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily &  Contains 2 fibronectin type-III domains &  Contains 1 protein kinase domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type: SwissProt: Q2TV78
uniprot_information:
Belongs to the peptidase S1 family. Plasminogen subfamily &  Contains 4 kringle domains &  Contains 1 PAN domain &  Contains 1 peptidase S1 domain


uniprot_information_type: SwissProt: P21912
uniprot_information:
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family &  Contains 1 2Fe-2S ferredoxin-type domain &  Contains 1 4Fe-4S ferredoxin-type domain


uniprot_information_type:
SwissProt: Q969V5 # The zinc finger domain is required for E3 ligase activity# Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q969V5 # The zinc finger domain is required for E3 ligase activity# Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: O43432
uniprot_information:
Belongs to the eIF4G family &  Contains 5 HEAT repeats &  Contains 1 MI domain &  Contains 1 MIF4G domain &  Contains 1 W2 domain


uniprot_information_type: SwissProt: P98160
uniprot_information:
Contains 4 EGF-like domains &  Contains 22 Ig-like C2-type (immunoglobulin-like) domains &  Contains 11 laminin EGF-like domains &  Contains 3 laminin G-like domains &  Contains 3 laminin IV type A domains &  Contains 4 LDL-receptor class A domains &  Contains 1 SEA domain


uniprot_information_type:
SwissProt: Q13761 # A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes# Contains 1 Runt domain

uniprot_information:
SwissProt: Q13761 # A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes# Contains 1 Runt domain


uniprot_information_type: SwissProt: O95382
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O75636
uniprot_information:
Belongs to the ficolin lectin family &  Contains 1 collagen-like domain &  Contains 1 fibrinogen C-terminal domain


uniprot_information_type: SwissProt: P09769
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily &  Contains 1 protein kinase domain &  Contains 1 SH2 domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q14671 # The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs# Contains 1 PUM-HD domain &  Contains 8 pumilio repeats

uniprot_information:
SwissProt: Q14671 # The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs# Contains 1 PUM-HD domain &  Contains 8 pumilio repeats


uniprot_information_type:
SwissProt: P05413 # Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

uniprot_information:
SwissProt: P05413 # Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


uniprot_information_type:
SwissProt: Q07092 # This sequence defines eighteen different domains, nine triple-helical domains (COL9 to COL1) and ten non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule either elastic or flexible# Belongs to the fibril-associated collagens with interrupted helices (FACIT) family &  Contains 1 TSP N-terminal (TSPN) domain

uniprot_information:
SwissProt: Q07092 # This sequence defines eighteen different domains, nine triple-helical domains (COL9 to COL1) and ten non-triple-helical domains (NC10 to NC1). The numerous interruptions in the triple helix may make this molecule either elastic or flexible# Belongs to the fibril-associated collagens with interrupted helices (FACIT) family &  Contains 1 TSP N-terminal (TSPN) domain


uniprot_information_type: SwissProt: O60241
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 1 GPS domain &  Contains 4 TSP type-1 domains


uniprot_information_type: SwissProt: Q12974
uniprot_information:
Belongs to the protein-tyrosine phosphatase family &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: Q6ZMZ0 # The first IBR-type zinc finger is the most crucial for interaction with UBE2L3, UBE2L6 and UCKL1# Belongs to the RBR family. RNF19 subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers

uniprot_information:
SwissProt: Q6ZMZ0 # The first IBR-type zinc finger is the most crucial for interaction with UBE2L3, UBE2L6 and UCKL1# Belongs to the RBR family. RNF19 subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers


uniprot_information_type: SwissProt: Q9BVG3
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q8IXK0 # HD1 motif interacts with SAM domain of PHC1# Contains 1 FCS-type zinc finger &  Contains 1 SAM (sterile alpha motif) domain

uniprot_information:
SwissProt: Q8IXK0 # HD1 motif interacts with SAM domain of PHC1# Contains 1 FCS-type zinc finger &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: Q99062 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 5 fibronectin type-III domains &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q99062 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 5 fibronectin type-III domains &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P32019
uniprot_information:
Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family &  Contains 1 Rho-GAP domain


uniprot_information_type: SwissProt: Q03052
uniprot_information:
Belongs to the POU transcription factor family. Class-3 subfamily &  Contains 1 homeobox DNA-binding domain &  Contains 1 POU-specific domain


uniprot_information_type: SwissProt: Q13310
uniprot_information:
Belongs to the polyadenylate-binding protein type-1 family &  Contains 1 PABC domain &  Contains 4 RRM (RNA recognition motif) domains


uniprot_information_type: SwissProt: Q9NQ87
uniprot_information:
Belongs to the HEY family &  Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain


uniprot_information_type:
SwissProt: Q5T1R4 # The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures (By similarity)# Contains 5 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q5T1R4 # The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures (By similarity)# Contains 5 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q9BW60 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the ELO family

uniprot_information:
SwissProt: Q9BW60 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the ELO family


uniprot_information_type:
SwissProt: Q96G25 # The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]# Belongs to the Mediator complex subunit 8 family

uniprot_information:
SwissProt: Q96G25 # The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]# Belongs to the Mediator complex subunit 8 family


uniprot_information_type: SwissProt: Q96S53
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8WZA1 # Amino acid residues between 299-311 are important for both protein expression and enzymatic activity. The minimal catalytic domain is located between positions 299-651. Single amino acid substitutions in the stem domain from MEB patients abolished the activity of the membrane-bound form but not the soluble form. This suggests that the stem domain of the soluble form is unnecessary for activity, but that some amino acids play a crucial role in the membrane-bound form# Belongs to the glycosyltransferase 13 family

uniprot_information:
SwissProt: Q8WZA1 # Amino acid residues between 299-311 are important for both protein expression and enzymatic activity. The minimal catalytic domain is located between positions 299-651. Single amino acid substitutions in the stem domain from MEB patients abolished the activity of the membrane-bound form but not the soluble form. This suggests that the stem domain of the soluble form is unnecessary for activity, but that some amino acids play a crucial role in the membrane-bound form# Belongs to the glycosyltransferase 13 family


uniprot_information_type:
SwissProt: Q15345 # The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]# Contains 7 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q15345 # The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]# Contains 7 LRR (leucine-rich) repeats


uniprot_information_type: SwissProt: Q9BUB5
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P17542 # The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1# Contains 1 basic helix-loop-helix (bHLH) domain

uniprot_information:
SwissProt: P17542 # The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1# Contains 1 basic helix-loop-helix (bHLH) domain


uniprot_information_type:
SwissProt: P42566 # The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins# Contains 2 EF-hand domains &  Contains 3 EH domains &  Contains 2 UIM (ubiquitin-interacting motif) repeats

uniprot_information:
SwissProt: P42566 # The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins# Contains 2 EF-hand domains &  Contains 3 EH domains &  Contains 2 UIM (ubiquitin-interacting motif) repeats


uniprot_information_type:
SwissProt: Q14114 # The cytoplasmic domain is involved in the binding of DAB1 and in the recruitment of JNK-interacting proteins. Isoforms, which lack part of the cytoplasmic domain, are unable to recruit members of the family of JNK interacting proteins (JIP) to the cytoplasmic tail (By similarity)# Belongs to the LDLR family &  Contains 2 EGF-like domains &  Contains 7 LDL-receptor class A domains &  Contains 5 LDL-receptor class B repeats

uniprot_information:
SwissProt: Q14114 # The cytoplasmic domain is involved in the binding of DAB1 and in the recruitment of JNK-interacting proteins. Isoforms, which lack part of the cytoplasmic domain, are unable to recruit members of the family of JNK interacting proteins (JIP) to the cytoplasmic tail (By similarity)# Belongs to the LDLR family &  Contains 2 EGF-like domains &  Contains 7 LDL-receptor class A domains &  Contains 5 LDL-receptor class B repeats


uniprot_information_type: SwissProt: Q15392
uniprot_information:
Belongs to the FAD-binding oxidoreductase/transferase type 4 family &  Contains 1 FAD-binding PCMH-type domain


uniprot_information_type: SwissProt: P07358
uniprot_information:
Belongs to the complement C6/C7/C8/C9 family &  Contains 1 EGF-like domain &  Contains 1 LDL-receptor class A domain &  Contains 1 MACPF domain &  Contains 2 TSP type-1 domains


uniprot_information_type:
SwissProt: O75553 # The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins# Contains 1 PID domain

uniprot_information:
SwissProt: O75553 # The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins# Contains 1 PID domain


uniprot_information_type:
SwissProt: Q13352 # The DD1 domain (also called RepD1 domain) mediates the corepressor function and is essential in the triggering of apoptosis &  Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, a motif known to be important for the association with nuclear receptors. Such motif, which is required for an efficient association with nuclear receptors, is however not essential &  Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, which is essential for the association with nuclear receptors#

uniprot_information:
SwissProt: Q13352 # The DD1 domain (also called RepD1 domain) mediates the corepressor function and is essential in the triggering of apoptosis &  Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, a motif known to be important for the association with nuclear receptors. Such motif, which is required for an efficient association with nuclear receptors, is however not essential &  Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, which is essential for the association with nuclear receptors#


uniprot_information_type:
SwissProt: P23458 # Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1 &  The FERM domain mediates interaction with JAKMIP1# Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily &  Contains 1 FERM domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain

uniprot_information:
SwissProt: P23458 # Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1 &  The FERM domain mediates interaction with JAKMIP1# Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily &  Contains 1 FERM domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain


uniprot_information_type:
SwissProt: Q8TEY7 # The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 86 is replaced by a Glu residue# Belongs to the peptidase C19 family. USP20/USP33 subfamily &  Contains 2 DUSP domains &  Contains 1 UBP-type zinc finger

uniprot_information:
SwissProt: Q8TEY7 # The UBP-type zinc finger binds 3 zinc ions. However, it does not bind ubiquitin, probably because the conserved Arg in position 86 is replaced by a Glu residue# Belongs to the peptidase C19 family. USP20/USP33 subfamily &  Contains 2 DUSP domains &  Contains 1 UBP-type zinc finger


uniprot_information_type:
SwissProt: Q9HBW9 # The transmembrane domain is not required for cleavage, but it is required for dimer formation (By similarity)# Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 2 EGF-like domains &  Contains 1 GPS domain

uniprot_information:
SwissProt: Q9HBW9 # The transmembrane domain is not required for cleavage, but it is required for dimer formation (By similarity)# Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 2 EGF-like domains &  Contains 1 GPS domain


uniprot_information_type:
SwissProt: Q9Y2D8 # Both the N-terminal (up to position 79) and the C-terminal (from position 304) sequences are required for interaction with SSX2#

uniprot_information:
SwissProt: Q9Y2D8 # Both the N-terminal (up to position 79) and the C-terminal (from position 304) sequences are required for interaction with SSX2#


uniprot_information_type:
SwissProt: Q99684 # The Gly/Ala-rich region may indicate that Gfi-1 is a repressor of its target genes# Contains 6 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q99684 # The Gly/Ala-rich region may indicate that Gfi-1 is a repressor of its target genes# Contains 6 C2H2-type zinc fingers


uniprot_information_type: SwissProt: Q15417
uniprot_information:
Belongs to the calponin family &  Contains 3 calponin-like repeats &  Contains 1 CH (calponin-homology) domain


uniprot_information_type: SwissProt: P12107
uniprot_information:
Belongs to the fibrillar collagen family &  Contains 1 fibrillar collagen NC1 domain &  Contains 1 TSP N-terminal (TSPN) domain


uniprot_information_type: SwissProt: Q9UKW4
uniprot_information:
Contains 1 CH (calponin-homology) domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 SH2 domain &  Contains 2 SH3 domains


uniprot_information_type: SwissProt: Q6NUK1
uniprot_information:
Belongs to the mitochondrial carrier family &  Contains 4 EF-hand domains &  Contains 3 Solcar repeats


uniprot_information_type:
SwissProt: Q15543 # The binding of TAF10 and TAF11 requires distinct domains of TAF13# Belongs to the TAF13 family &  Contains 1 histone-fold domain

uniprot_information:
SwissProt: Q15543 # The binding of TAF10 and TAF11 requires distinct domains of TAF13# Belongs to the TAF13 family &  Contains 1 histone-fold domain


uniprot_information_type:
SwissProt: Q99523 # The N-terminal propeptide may facilitate precursor transport within the Golgi stack. Intrachain binding of the N-terminal propeptide and the extracellular domain may also inhibit premature ligand binding &  The extracellular domain may be shed following protease cleavage in some cell types# Belongs to the SORT1 family &  Contains 9 BNR repeats

uniprot_information:
SwissProt: Q99523 # The N-terminal propeptide may facilitate precursor transport within the Golgi stack. Intrachain binding of the N-terminal propeptide and the extracellular domain may also inhibit premature ligand binding &  The extracellular domain may be shed following protease cleavage in some cell types# Belongs to the SORT1 family &  Contains 9 BNR repeats


uniprot_information_type: SwissProt: P21266
uniprot_information:
Belongs to the GST superfamily. Mu family &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain


uniprot_information_type:
SwissProt: Q16322 # The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments &  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily

uniprot_information:
SwissProt: Q16322 # The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments &  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily


uniprot_information_type:
SwissProt: P16389 # The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments &  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily

uniprot_information:
SwissProt: P16389 # The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments &  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily


uniprot_information_type:
SwissProt: P22001 # The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments &  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily

uniprot_information:
SwissProt: P22001 # The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments &  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily


uniprot_information_type:
SwissProt: Q9UK17 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily

uniprot_information:
SwissProt: Q9UK17 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily


uniprot_information_type: SwissProt: Q9Y2R2
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type: SwissProt: Q9UPN9
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 bromo domain &  Contains 1 PHD-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q9H8W5
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 filamin repeat &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q7Z7D3
uniprot_information:
Belongs to the immunoglobulin superfamily. BTN/MOG family &  Contains 2 Ig-like V-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q9UKF2 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: Q9UKF2 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain


uniprot_information_type: SwissProt: Q04721
uniprot_information:
Belongs to the NOTCH family &  Contains 6 ANK repeats &  Contains 35 EGF-like domains &  Contains 3 LNR (Lin/Notch) repeats


uniprot_information_type: SwissProt: A4FU01
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily &  Contains 1 myotubularin phosphatase domain


uniprot_information_type: SwissProt: P27540
uniprot_information:
Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 2 PAS (PER-ARNT-SIM) domains


uniprot_information_type:
SwissProt: Q9NRR8 # The CRIB domain mediates interaction with CDC42# Belongs to the CDC42SE/SPEC family &  Contains 1 CRIB domain

uniprot_information:
SwissProt: Q9NRR8 # The CRIB domain mediates interaction with CDC42# Belongs to the CDC42SE/SPEC family &  Contains 1 CRIB domain


uniprot_information_type:
SwissProt: P48382 # The N-terminus is required for its association with RFXANK and RFXAP, for assembly of the RFX complex, and for binding of this complex to its X box target site in the MHC-II promoter. The C-terminus mediates cooperative binding between the RFX complex and NF-Y# Belongs to the RFX family &  Contains 1 H-T-H motif winged-type DNA-binding domain

uniprot_information:
SwissProt: P48382 # The N-terminus is required for its association with RFXANK and RFXAP, for assembly of the RFX complex, and for binding of this complex to its X box target site in the MHC-II promoter. The C-terminus mediates cooperative binding between the RFX complex and NF-Y# Belongs to the RFX family &  Contains 1 H-T-H motif winged-type DNA-binding domain


uniprot_information_type: SwissProt: Q7Z3K3
uniprot_information:
Contains 9 C2H2-type zinc fingers &  Contains 1 DDE domain &  Contains 1 HTH CENPB-type DNA-binding domain


uniprot_information_type: SwissProt: P51449
uniprot_information:
Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: Q07283 # Consists of nine domains. Domain 1 contains two EF-hand calcium-binding domains. Domains 2-4, 6, and 8 are almost entirely alpha-helical, configured as a series of peptide repeats of varying regularity, and are thought to form a single-stranded alpha-helical rod stabilized by ionic interactions. Domain 6 is the most regular and may bind KIF directly by ionic interactions. Domains 5 and 7 are less well organized and may induce folds in the molecule. Domain 9 contains the C-terminus, conserved among different species# Belongs to the S100-fused protein family &  Contains 2 EF-hand domains

uniprot_information:
SwissProt: Q07283 # Consists of nine domains. Domain 1 contains two EF-hand calcium-binding domains. Domains 2-4, 6, and 8 are almost entirely alpha-helical, configured as a series of peptide repeats of varying regularity, and are thought to form a single-stranded alpha-helical rod stabilized by ionic interactions. Domain 6 is the most regular and may bind KIF directly by ionic interactions. Domains 5 and 7 are less well organized and may induce folds in the molecule. Domain 9 contains the C-terminus, conserved among different species# Belongs to the S100-fused protein family &  Contains 2 EF-hand domains


uniprot_information_type: SwissProt: P20930
uniprot_information:
Belongs to the S100-fused protein family &  Contains 2 EF-hand domains &  Contains 23 filaggrin repeats


uniprot_information_type: SwissProt: O75064
uniprot_information:
Contains 1 dDENN domain &  Contains 1 DENN domain &  Contains 1 MABP domain &  Contains 2 PPR (pentatricopeptide) repeats &  Contains 1 uDENN domain


uniprot_information_type:
SwissProt: P06753 # The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity# Belongs to the tropomyosin family

uniprot_information:
SwissProt: P06753 # The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity# Belongs to the tropomyosin family


uniprot_information_type: SwissProt: P55265
uniprot_information:
Contains 1 A to I editase domain &  Contains 2 DRADA repeats &  Contains 3 DRBM (double-stranded RNA-binding) domains


uniprot_information_type:
SwissProt: Q96AQ6 # The C-terminal domain (AA 443-731) contains a nuclear export signal &  Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218) #

uniprot_information:
SwissProt: Q96AQ6 # The C-terminal domain (AA 443-731) contains a nuclear export signal &  Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218) #


uniprot_information_type:
SwissProt: P29353 # In response to a variety of growth factors, isoform p46Shc and isoform p52Shc bind to phosphorylated Trk receptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specific phosphorylated tyrosine residues in the Asn-Pro-Xaa-Tyr(P) motif of the Trk receptors. Isoform p46Shc and isoform p52Shc are in turn phosphorylated on three tyrosine residues within the extended proline-rich domain. These phosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation (By similarity)# Contains 1 PID domain &  Contains 1 SH2 domain

uniprot_information:
SwissProt: P29353 # In response to a variety of growth factors, isoform p46Shc and isoform p52Shc bind to phosphorylated Trk receptors through their phosphotyrosine binding (PID) and/or SH2 domains. The PID and SH2 domains bind to specific phosphorylated tyrosine residues in the Asn-Pro-Xaa-Tyr(P) motif of the Trk receptors. Isoform p46Shc and isoform p52Shc are in turn phosphorylated on three tyrosine residues within the extended proline-rich domain. These phosphotyrosines act as docking site for GRB2 and thereby are involved in Ras activation (By similarity)# Contains 1 PID domain &  Contains 1 SH2 domain


uniprot_information_type: SwissProt: P49746
uniprot_information:
Belongs to the thrombospondin family &  Contains 4 EGF-like domains &  Contains 1 TSP C-terminal (TSPC) domain &  Contains 1 TSP N-terminal (TSPN) domain &  Contains 8 TSP type-3 repeats


uniprot_information_type: SwissProt: P49760
uniprot_information:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9NR48
uniprot_information:
Belongs to the histone-lysine methyltransferase family. SET2 subfamily &  Contains 3 A.T hook DNA-binding domains &  Contains 1 AWS domain &  Contains 1 BAH domain &  Contains 1 bromo domain &  Contains 1 PHD-type zinc finger &  Contains 1 post-SET domain &  Contains 1 SET domain


uniprot_information_type:
SwissProt: Q92974 # The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA &  The PH (pleckstrin-homology) domain is involved in microtubule binding and targeting to tight junctions# Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger

uniprot_information:
SwissProt: Q92974 # The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA &  The PH (pleckstrin-homology) domain is involved in microtubule binding and targeting to tight junctions# Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger


uniprot_information_type:
SwissProt: Q14814 # The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity# Belongs to the MEF2 family &  Contains 1 MADS-box domain &  Contains 1 Mef2-type DNA-binding domain

uniprot_information:
SwissProt: Q14814 # The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity# Belongs to the MEF2 family &  Contains 1 MADS-box domain &  Contains 1 Mef2-type DNA-binding domain


uniprot_information_type:
SwissProt: P29373 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

uniprot_information:
SwissProt: P29373 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


uniprot_information_type:
SwissProt: P51858 # The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal region is essentially unstructured# Belongs to the HDGF family &  Contains 1 PWWP domain

uniprot_information:
SwissProt: P51858 # The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal region is essentially unstructured# Belongs to the HDGF family &  Contains 1 PWWP domain


uniprot_information_type: SwissProt: P14616
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily &  Contains 3 fibronectin type-III domains &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O15085 # The poly-Pro region is essential for plasma membrane localization upon stimulation# Contains 1 DH (DBL-homology) domain &  Contains 1 PDZ (DHR) domain &  Contains 1 PH domain &  Contains 1 RGSL (RGS-like) domain

uniprot_information:
SwissProt: O15085 # The poly-Pro region is essential for plasma membrane localization upon stimulation# Contains 1 DH (DBL-homology) domain &  Contains 1 PDZ (DHR) domain &  Contains 1 PH domain &  Contains 1 RGSL (RGS-like) domain


uniprot_information_type:
SwissProt: Q96LA5 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6# Contains 4 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: Q96LA5 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6# Contains 4 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: P02549
uniprot_information:
Belongs to the spectrin family &  Contains 3 EF-hand domains &  Contains 1 SH3 domain &  Contains 21 spectrin repeats


uniprot_information_type: SwissProt: P37802
uniprot_information:
Belongs to the calponin family &  Contains 1 calponin-like repeat &  Contains 1 CH (calponin-homology) domain


uniprot_information_type:
SwissProt: Q9UIB8 # ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A# Contains 1 Ig-like C2-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q9UIB8 # ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A# Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q13291 # The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues# Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q13291 # The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues# Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P09326
uniprot_information:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: Q9Y624
uniprot_information:
Belongs to the immunoglobulin superfamily &  Contains 2 Ig-like V-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q14994 # Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: Q14994 # Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: P48443 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain (By similarity)# Belongs to the nuclear hormone receptor family. NR2 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P48443 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain (By similarity)# Belongs to the nuclear hormone receptor family. NR2 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: P20963 # The ITAM domains mediate interaction with SHB# Belongs to the CD3Z/FCER1G family &  Contains 3 ITAM domains

uniprot_information:
SwissProt: P20963 # The ITAM domains mediate interaction with SHB# Belongs to the CD3Z/FCER1G family &  Contains 3 ITAM domains


uniprot_information_type: SwissProt: Q96PN6
uniprot_information:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family &  Contains 2 guanylate cyclase domains


uniprot_information_type:
SwissProt: P12259 # Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats# Belongs to the multicopper oxidase family &  Contains 3 F5/8 type A domains &  Contains 2 F5/8 type C domains &  Contains 6 plastocyanin-like domains

uniprot_information:
SwissProt: P12259 # Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats# Belongs to the multicopper oxidase family &  Contains 3 F5/8 type A domains &  Contains 2 F5/8 type C domains &  Contains 6 plastocyanin-like domains


uniprot_information_type: SwissProt: P16109
uniprot_information:
Belongs to the selectin/LECAM family &  Contains 1 C-type lectin domain &  Contains 1 EGF-like domain &  Contains 9 Sushi (CCP/SCR) domains


uniprot_information_type: SwissProt: P14151
uniprot_information:
Belongs to the selectin/LECAM family &  Contains 1 C-type lectin domain &  Contains 1 EGF-like domain &  Contains 2 Sushi (CCP/SCR) domains


uniprot_information_type: SwissProt: P16581
uniprot_information:
Belongs to the selectin/LECAM family &  Contains 1 C-type lectin domain &  Contains 1 EGF-like domain &  Contains 6 Sushi (CCP/SCR) domains


uniprot_information_type:
SwissProt: Q8IZE3 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily &  Contains 4 HEAT repeats &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q8IZE3 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily &  Contains 4 HEAT repeats &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q92752 # The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B (By similarity)# Belongs to the tenascin family &  Contains 5 EGF-like domains &  Contains 1 fibrinogen C-terminal domain &  Contains 9 fibronectin type-III domains

uniprot_information:
SwissProt: Q92752 # The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B (By similarity)# Belongs to the tenascin family &  Contains 5 EGF-like domains &  Contains 1 fibrinogen C-terminal domain &  Contains 9 fibronectin type-III domains


uniprot_information_type: SwissProt: O14525
uniprot_information:
Belongs to the astrotactin family &  Contains 3 EGF-like domains &  Contains 1 fibronectin type-III domain


uniprot_information_type: SwissProt: P42684
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily &  Contains 1 protein kinase domain &  Contains 1 SH2 domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q05823 # The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain &  The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization &  The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is sufficient for ribonuclease activity (By similarity)# Belongs to the protein kinase superfamily &  Contains 9 ANK repeats &  Contains 1 KEN domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q05823 # The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain &  The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization &  The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is sufficient for ribonuclease activity (By similarity)# Belongs to the protein kinase superfamily &  Contains 9 ANK repeats &  Contains 1 KEN domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: P19878
uniprot_information:
Belongs to the NCF2/NOXA1 family &  Contains 1 OPR domain &  Contains 2 SH3 domains &  Contains 3 TPR repeats


uniprot_information_type:
SwissProt: Q9BZQ6 # Contains a protease-associated domain (PA) of unknown function# Belongs to the glycosyl hydrolase 47 family &  Contains 1 PA (protease associated) domain

uniprot_information:
SwissProt: Q9BZQ6 # Contains a protease-associated domain (PA) of unknown function# Belongs to the glycosyl hydrolase 47 family &  Contains 1 PA (protease associated) domain


uniprot_information_type:
SwissProt: Q9Y6Y0 # When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus, the BTB domain inhibits AHR signaling induced by IVNS1ABP# Contains 1 BACK (BTB/Kelch associated) domain &  Contains 1 BTB (POZ) domain &  Contains 6 Kelch repeats

uniprot_information:
SwissProt: Q9Y6Y0 # When the BTB domain is lacking, AHR signaling induction promoted by IVNS1ABP is massively increased; Thus, the BTB domain inhibits AHR signaling induced by IVNS1ABP# Contains 1 BACK (BTB/Kelch associated) domain &  Contains 1 BTB (POZ) domain &  Contains 6 Kelch repeats


uniprot_information_type: SwissProt: Q15058
uniprot_information:
Belongs to the kinesin-like protein family &  Contains 1 FHA domain &  Contains 1 kinesin-motor domain


uniprot_information_type: SwissProt: O75037
uniprot_information:
Belongs to the kinesin-like protein family &  Contains 1 kinesin-motor domain &  Contains 7 WD repeats


uniprot_information_type:
SwissProt: Q13698 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position &  The loop between repeats II and III interacts with the ryanodine receptor, and is therefore important for calcium release from the endoplasmic reticulum necessary for muscle contraction# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1S subfamily

uniprot_information:
SwissProt: Q13698 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position &  The loop between repeats II and III interacts with the ryanodine receptor, and is therefore important for calcium release from the endoplasmic reticulum necessary for muscle contraction# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1S subfamily


uniprot_information_type:
SwissProt: Q9Y5J5 # The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling# Belongs to the PHLDA3 family &  Contains 1 PH domain

uniprot_information:
SwissProt: Q9Y5J5 # The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling# Belongs to the PHLDA3 family &  Contains 1 PH domain


uniprot_information_type: SwissProt: P35236
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: Q8N9I0 # The first C2 domain mediates Ca(2+)-dependent phospholipid binding (By similarity) &  The second C2 domain mediates interaction with Stonin 2 (By similarity)# Belongs to the synaptotagmin family &  Contains 2 C2 domains

uniprot_information:
SwissProt: Q8N9I0 # The first C2 domain mediates Ca(2+)-dependent phospholipid binding (By similarity) &  The second C2 domain mediates interaction with Stonin 2 (By similarity)# Belongs to the synaptotagmin family &  Contains 2 C2 domains


uniprot_information_type:
SwissProt: Q9UGL1 # Both the JmjC domain and the JmjN domain are required for enzymatic activity &  The 2 first PHD-type zinc finger domains are required for transcription repression activity# Belongs to the JARID1 histone demethylase family &  Contains 1 ARID domain &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 3 PHD-type zinc fingers

uniprot_information:
SwissProt: Q9UGL1 # Both the JmjC domain and the JmjN domain are required for enzymatic activity &  The 2 first PHD-type zinc finger domains are required for transcription repression activity# Belongs to the JARID1 histone demethylase family &  Contains 1 ARID domain &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 3 PHD-type zinc fingers


uniprot_information_type:
SwissProt: Q53G59 # The BTB domain is required for interaction with CUL3# Contains 1 BTB (POZ) domain &  Contains 6 Kelch repeats

uniprot_information:
SwissProt: Q53G59 # The BTB domain is required for interaction with CUL3# Contains 1 BTB (POZ) domain &  Contains 6 Kelch repeats


uniprot_information_type:
SwissProt: Q96A54 # The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular# Belongs to the ADIPOR family

uniprot_information:
SwissProt: Q96A54 # The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular# Belongs to the ADIPOR family


uniprot_information_type: SwissProt: Q9UHQ9
uniprot_information:
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family &  Contains 1 FAD-binding FR-type domain


uniprot_information_type: SwissProt: Q13231
uniprot_information:
Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily &  Contains 1 chitin-binding type-2 domain


uniprot_information_type: SwissProt: Q06828
uniprot_information:
Belongs to the small leucine-rich proteoglycan (SLRP) family. Class II subfamily &  Contains 12 LRR (leucine-rich) repeats


uniprot_information_type: SwissProt: O00750
uniprot_information:
Belongs to the PI3/PI4-kinase family &  Contains 1 C2 domain &  Contains 1 PI3K/PI4K domain &  Contains 1 PX (phox homology) domain


uniprot_information_type: SwissProt: Q6XUX3
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9H093
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O60667 # The Ig-like domain is required for the anti-apoptotic ability# Contains 1 Ig-like (immunoglobulin-like) domain

uniprot_information:
SwissProt: O60667 # The Ig-like domain is required for the anti-apoptotic ability# Contains 1 Ig-like (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q5VVQ6 # The UBAX-like region mediates the interaction with VCP. According to PubMed:19818707, it corresponds to a UBX domain, which is a hallmark for VCP-associated proteins. However, no canonical UBX is detected by prediction tools such as Pfam or PROSITE# Contains 1 C2H2-type zinc finger &  Contains 1 OTU domain

uniprot_information:
SwissProt: Q5VVQ6 # The UBAX-like region mediates the interaction with VCP. According to PubMed:19818707, it corresponds to a UBX domain, which is a hallmark for VCP-associated proteins. However, no canonical UBX is detected by prediction tools such as Pfam or PROSITE# Contains 1 C2H2-type zinc finger &  Contains 1 OTU domain


uniprot_information_type:
SwissProt: Q13751 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domain VI is globular# Contains 6 laminin EGF-like domains &  Contains 1 laminin N-terminal domain

uniprot_information:
SwissProt: Q13751 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domain VI is globular# Contains 6 laminin EGF-like domains &  Contains 1 laminin N-terminal domain


uniprot_information_type:
SwissProt: O95259 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily &  Contains 1 cyclic nucleotide-binding domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain

uniprot_information:
SwissProt: O95259 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily &  Contains 1 cyclic nucleotide-binding domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain


uniprot_information_type: SwissProt: P51955
uniprot_information:
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q92604 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

uniprot_information:
SwissProt: Q92604 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


uniprot_information_type: SwissProt: Q15678
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily &  Contains 1 FERM domain &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type: SwissProt: P62508
uniprot_information:
Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: P07814 # The WHEP-TRS domain is involved in RNA binding# In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family &  In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family &  Contains 3 WHEP-TRS domains

uniprot_information:
SwissProt: P07814 # The WHEP-TRS domain is involved in RNA binding# In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family &  In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family &  Contains 3 WHEP-TRS domains


uniprot_information_type: SwissProt: Q9Y6W6
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily &  Contains 1 rhodanese domain &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type: SwissProt: O60602
uniprot_information:
Belongs to the Toll-like receptor family &  Contains 15 LRR (leucine-rich) repeats &  Contains 1 TIR domain


uniprot_information_type:
SwissProt: Q13625 # The ankyrin repeats and the SH3 domain are required for a specific interactions with TP53# Belongs to the ASPP family &  Contains 2 ANK repeats &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q13625 # The ankyrin repeats and the SH3 domain are required for a specific interactions with TP53# Belongs to the ASPP family &  Contains 2 ANK repeats &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q8N8S7 # The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization# Belongs to the Ena/VASP family &  Contains 1 WH1 domain

uniprot_information:
SwissProt: Q8N8S7 # The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization# Belongs to the Ena/VASP family &  Contains 1 WH1 domain


uniprot_information_type:
SwissProt: Q9H3P7 # The GOLD domain is essential for giantin binding# Contains 1 ACB (acyl-CoA-binding) domain &  Contains 1 GOLD domain

uniprot_information:
SwissProt: Q9H3P7 # The GOLD domain is essential for giantin binding# Contains 1 ACB (acyl-CoA-binding) domain &  Contains 1 GOLD domain


uniprot_information_type: SwissProt: P09874
uniprot_information:
Contains 1 BRCT domain &  Contains 1 PARP alpha-helical domain &  Contains 1 PARP catalytic domain &  Contains 2 PARP-type zinc fingers


uniprot_information_type: SwissProt: Q5VT25
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 CNH domain &  Contains 1 CRIB domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q4LE39 # The C-terminus mediates interaction with mSin3A corepressor complex &  The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms &  The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA# Contains 1 ARID domain

uniprot_information:
SwissProt: Q4LE39 # The C-terminus mediates interaction with mSin3A corepressor complex &  The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms &  The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA# Contains 1 ARID domain


uniprot_information_type: SwissProt: P14543
uniprot_information:
Contains 6 EGF-like domains &  Contains 4 LDL-receptor class B repeats &  Contains 1 NIDO domain &  Contains 1 nidogen G2 beta-barrel domain &  Contains 1 thyroglobulin type-1 domain


uniprot_information_type:
SwissProt: Q9Y243 # Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q9Y243 # Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9H7B4
uniprot_information:
Belongs to the histone-lysine methyltransferase family &  Contains 1 MYND-type zinc finger &  Contains 1 SET domain


uniprot_information_type: SwissProt: Q9H5Q4
uniprot_information:
Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily


uniprot_information_type: SwissProt: Q96BR6
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 9 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: Q15973
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 8 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: O00468
uniprot_information:
Contains 4 EGF-like domains &  Contains 9 Kazal-like domains &  Contains 2 laminin EGF-like domains &  Contains 3 laminin G-like domains &  Contains 1 NtA (N-terminal agrin) domain &  Contains 1 SEA domain


uniprot_information_type: SwissProt: O14764
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily


uniprot_information_type:
SwissProt: Q05513 # The OPR domain mediates mutually exclusive interactions with SQSTM1 and PARD6B &  The C1 domain does not bind the diacylglycerol (DAG)# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 OPR domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q05513 # The OPR domain mediates mutually exclusive interactions with SQSTM1 and PARD6B &  The C1 domain does not bind the diacylglycerol (DAG)# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 OPR domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O75038
uniprot_information:
Contains 1 C2 domain &  Contains 2 EF-hand domains &  Contains 1 PH domain &  Contains 1 PI-PLC X-box domain &  Contains 1 PI-PLC Y-box domain


uniprot_information_type:
SwissProt: O15350 # Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL tyrosine kinase SH3 domain &  The WW-binding motif mediates interaction with WWOX# Belongs to the p53 family &  Contains 1 SAM (sterile alpha motif) domain

uniprot_information:
SwissProt: O15350 # Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL tyrosine kinase SH3 domain &  The WW-binding motif mediates interaction with WWOX# Belongs to the p53 family &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: Q13303 # Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (Probable)# Belongs to the shaker potassium channel beta subunit family

uniprot_information:
SwissProt: Q13303 # Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (Probable)# Belongs to the shaker potassium channel beta subunit family


uniprot_information_type: SwissProt: P10074
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 11 C2H2-type zinc fingers


uniprot_information_type: SwissProt: Q9Y6Y1
uniprot_information:
Belongs to the CAMTA family &  Contains 3 ANK repeats &  Contains 1 CG-1 DNA-binding domain &  Contains 1 IPT/TIG domain &  Contains 3 IQ domains


uniprot_information_type: SwissProt: O95479
uniprot_information:
In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family &  In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily


uniprot_information_type:
SwissProt: Q96BD6 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). The B30.2/SPRY domain is involved in MET binding# Belongs to the SPSB family &  Contains 1 B30.2/SPRY domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q96BD6 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). The B30.2/SPRY domain is involved in MET binding# Belongs to the SPSB family &  Contains 1 B30.2/SPRY domain &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: O60333
uniprot_information:
Belongs to the kinesin-like protein family. Unc-104 subfamily &  Contains 1 FHA domain &  Contains 1 kinesin-motor domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q96T58 # The RID domain mediates the interaction with nuclear receptors (By similarity) &  The SPOC domain, which mediates the interaction with NCOR2, is essential for the repressive activity# Belongs to the RRM Spen family &  Contains 1 RID (receptor interacting) domain &  Contains 4 RRM (RNA recognition motif) domains &  Contains 1 SPOC domain

uniprot_information:
SwissProt: Q96T58 # The RID domain mediates the interaction with nuclear receptors (By similarity) &  The SPOC domain, which mediates the interaction with NCOR2, is essential for the repressive activity# Belongs to the RRM Spen family &  Contains 1 RID (receptor interacting) domain &  Contains 4 RRM (RNA recognition motif) domains &  Contains 1 SPOC domain


uniprot_information_type:
SwissProt: Q9NVZ3 # The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity)# Belongs to the NECAP family

uniprot_information:
SwissProt: Q9NVZ3 # The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity)# Belongs to the NECAP family


uniprot_information_type: SwissProt: P23759
uniprot_information:
Belongs to the paired homeobox family &  Contains 1 homeobox DNA-binding domain &  Contains 1 paired domain


uniprot_information_type: SwissProt: Q9NUA8
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 12 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: O60341 # The SWIRN domain may act as an anchor site for a histone tail# Belongs to the flavin monoamine oxidase family &  Contains 1 SWIRM domain

uniprot_information:
SwissProt: O60341 # The SWIRN domain may act as an anchor site for a histone tail# Belongs to the flavin monoamine oxidase family &  Contains 1 SWIRM domain


uniprot_information_type:
SwissProt: Q14241 # The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]# Contains 1 F-box domain &  Contains 1 TFIIS N-terminal domain

uniprot_information:
SwissProt: Q14241 # The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]# Contains 1 F-box domain &  Contains 1 TFIIS N-terminal domain


uniprot_information_type:
SwissProt: Q9NPJ4 # The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif# Belongs to the PNRC family. PNRC2 subfamily

uniprot_information:
SwissProt: Q9NPJ4 # The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif# Belongs to the PNRC family. PNRC2 subfamily


uniprot_information_type:
SwissProt: Q9Y696 # Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion# Belongs to the chloride channel CLIC family &  Contains 1 GST C-terminal domain

uniprot_information:
SwissProt: Q9Y696 # Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion# Belongs to the chloride channel CLIC family &  Contains 1 GST C-terminal domain


uniprot_information_type:
SwissProt: Q5SW96 # The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1# Contains 1 PID domain

uniprot_information:
SwissProt: Q5SW96 # The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1# Contains 1 PID domain


uniprot_information_type:
SwissProt: O00488 # The protein is largely disordered, with the exception of the zinc finger domain# Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family &  Contains 1 C2H2-type zinc finger

uniprot_information:
SwissProt: O00488 # The protein is largely disordered, with the exception of the zinc finger domain# Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family &  Contains 1 C2H2-type zinc finger


uniprot_information_type: SwissProt: Q969H4
uniprot_information:
Belongs to the CNKSR family &  Contains 1 CRIC domain &  Contains 1 PDZ (DHR) domain &  Contains 1 PH domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: Q9H9Z2 # The CSD domain is required for function in muscle differentiation (By similarity)# Belongs to the lin-28 family &  Contains 2 CCHC-type zinc fingers &  Contains 1 CSD (cold-shock) domain

uniprot_information:
SwissProt: Q9H9Z2 # The CSD domain is required for function in muscle differentiation (By similarity)# Belongs to the lin-28 family &  Contains 2 CCHC-type zinc fingers &  Contains 1 CSD (cold-shock) domain


uniprot_information_type: SwissProt: Q15418
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 2 protein kinase domains


uniprot_information_type:
SwissProt: Q9NUE0 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q9NUE0 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: Q12972 # Has a basic N- and C-terminal and an acidic central domain# Contains 1 FHA domain

uniprot_information:
SwissProt: Q12972 # Has a basic N- and C-terminal and an acidic central domain# Contains 1 FHA domain


uniprot_information_type: SwissProt: Q92729
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily &  Contains 4 fibronectin type-III domains &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 MAM domain &  Contains 2 tyrosine-protein phosphatase domains


uniprot_information_type:
SwissProt: Q07666 # The KH domain is required for binding to RNA (By similarity) &  The Pro-rich domains are flanked by Arg/Gly-rich motifs which can be asymmetric dimethylated on arginine residues to give the DMA/Gly-rich regions. Selective methylation on these motifs can modulate protein-protein interactions (By similarity)# Belongs to the KHDRBS family &  Contains 1 KH domain

uniprot_information:
SwissProt: Q07666 # The KH domain is required for binding to RNA (By similarity) &  The Pro-rich domains are flanked by Arg/Gly-rich motifs which can be asymmetric dimethylated on arginine residues to give the DMA/Gly-rich regions. Selective methylation on these motifs can modulate protein-protein interactions (By similarity)# Belongs to the KHDRBS family &  Contains 1 KH domain


uniprot_information_type:
SwissProt: P06239 # The SH2 domain mediates interaction with SQSTM1. Interaction is regulated by Ser-59 phosphorylation# Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily &  Contains 1 protein kinase domain &  Contains 1 SH2 domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: P06239 # The SH2 domain mediates interaction with SQSTM1. Interaction is regulated by Ser-59 phosphorylation# Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily &  Contains 1 protein kinase domain &  Contains 1 SH2 domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q53HL2 # The C-terminal region (aa 207-280) represents the dimerization motif# Belongs to the borealin family

uniprot_information:
SwissProt: Q53HL2 # The C-terminal region (aa 207-280) represents the dimerization motif# Belongs to the borealin family


uniprot_information_type: SwissProt: Q9UPN3
uniprot_information:
Belongs to the plakin or cytolinker family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 2 EF-hand domains &  Contains 1 GAR domain &  Contains 1 SH3 domain &  Contains 37 spectrin repeats


uniprot_information_type: Q96PK2
uniprot_information:
Belongs to the plakin or cytolinker family &  Contains 2 EF-hand domains &  Contains 1 GAR domain &  Contains 19 plectin repeats &  Contains 32 spectrin repeats


uniprot_information_type: SwissProt: Q9UNP9
uniprot_information:
Belongs to the cyclophilin-type PPIase family. PPIase E subfamily &  Contains 1 PPIase cyclophilin-type domain &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: P56696 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily

uniprot_information:
SwissProt: P56696 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily


uniprot_information_type: SwissProt: O43447
uniprot_information:
Belongs to the cyclophilin-type PPIase family. PPIase H subfamily &  Contains 1 PPIase cyclophilin-type domain


uniprot_information_type: SwissProt: Q96PL5
uniprot_information:
Belongs to the immunoglobulin superfamily. BTN/MOG family &  Contains 1 B30.2/SPRY domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P35590
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily &  Contains 3 EGF-like domains &  Contains 3 fibronectin type-III domains &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P40238 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 1 subfamily &  Contains 2 fibronectin type-III domains

uniprot_information:
SwissProt: P40238 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 1 subfamily &  Contains 2 fibronectin type-III domains


uniprot_information_type: SwissProt: P10586
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily &  Contains 8 fibronectin type-III domains &  Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 2 tyrosine-protein phosphatase domains


uniprot_information_type:
SwissProt: O75164 # The 2 Tudor domains recognize and bind methylated histone H3 'Lys-4' residue. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails. Trimethylated H3 'Lys-4' is bound in a cage of 3 aromatic residues, 2 of which are from the Tudor domain 2, while the binding specificity is determined by side-chain interactions involving residues from the Tudor domain 1. The Tudor domains are able to bind trimethylated histone H3 'Lys-4', trimethylated histone H3 'Lys-9', di- and trimethylated H4 'Lys-20'# Belongs to the JHDM3 histone demethylase family &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 2 PHD-type zinc fingers &  Contains 2 Tudor domains

uniprot_information:
SwissProt: O75164 # The 2 Tudor domains recognize and bind methylated histone H3 'Lys-4' residue. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails. Trimethylated H3 'Lys-4' is bound in a cage of 3 aromatic residues, 2 of which are from the Tudor domain 2, while the binding specificity is determined by side-chain interactions involving residues from the Tudor domain 1. The Tudor domains are able to bind trimethylated histone H3 'Lys-4', trimethylated histone H3 'Lys-9', di- and trimethylated H4 'Lys-20'# Belongs to the JHDM3 histone demethylase family &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 2 PHD-type zinc fingers &  Contains 2 Tudor domains


uniprot_information_type: SwissProt: O94829
uniprot_information:
Belongs to the importin beta family &  Contains 14 HEAT repeats &  Contains 1 importin N-terminal domain


uniprot_information_type:
SwissProt: Q99661 # The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends# Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily &  Contains 1 kinesin-motor domain

uniprot_information:
SwissProt: Q99661 # The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends# Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily &  Contains 1 kinesin-motor domain


uniprot_information_type: SwissProt: Q9H4B4
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily &  Contains 2 POLO box domains &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q6P0Q8
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PDZ (DHR) domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q92698
uniprot_information:
Belongs to the SNF2/RAD54 helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q9Y3C5 # The WW-binding motif mediates interaction with NEDD4 (By similarity)# Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q9Y3C5 # The WW-binding motif mediates interaction with NEDD4 (By similarity)# Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: O95405 # The SMAD binding domain (SBD) interacts with the MH2 domain of SMAD2 or SMAD3 &  The FYVE-type zinc finger domain (also called double zinc finger domain) is required to maintain the normal localization of the protein but is not involved in mediating interaction with SMADs. Can bind phosphatidyl inositol-3 phosphate# Contains 1 FYVE-type zinc finger

uniprot_information:
SwissProt: O95405 # The SMAD binding domain (SBD) interacts with the MH2 domain of SMAD2 or SMAD3 &  The FYVE-type zinc finger domain (also called double zinc finger domain) is required to maintain the normal localization of the protein but is not involved in mediating interaction with SMADs. Can bind phosphatidyl inositol-3 phosphate# Contains 1 FYVE-type zinc finger


uniprot_information_type:
SwissProt: Q8NI35 # The L27 domain (also called Maguk recruitment domain) is required for interaction with MPP5 and CRB3, and MPP5 localization to tight junctions &  The PDZ domain 6 mediates interaction with the C-terminus of TJP3 and is crucial for localization to the tight junctions. The PDZ domain 8 interacts with CLDN1 but is not required for proper localization# Contains 1 L27 domain &  Contains 10 PDZ (DHR) domains

uniprot_information:
SwissProt: Q8NI35 # The L27 domain (also called Maguk recruitment domain) is required for interaction with MPP5 and CRB3, and MPP5 localization to tight junctions &  The PDZ domain 6 mediates interaction with the C-terminus of TJP3 and is crucial for localization to the tight junctions. The PDZ domain 8 interacts with CLDN1 but is not required for proper localization# Contains 1 L27 domain &  Contains 10 PDZ (DHR) domains


uniprot_information_type: SwissProt: Q01973
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily &  Contains 1 FZ (frizzled) domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 kringle domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O75061
uniprot_information:
Contains 1 C2 tensin-type domain &  Contains 1 J domain &  Contains 1 phosphatase tensin-type domain


uniprot_information_type:
SwissProt: P48357 # The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs &  The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 4 fibronectin type-III domains &  Contains 1 Ig-like (immunoglobulin-like) domain

uniprot_information:
SwissProt: P48357 # The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs &  The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 4 fibronectin type-III domains &  Contains 1 Ig-like (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q99665 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 5 fibronectin type-III domains

uniprot_information:
SwissProt: Q99665 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 5 fibronectin type-III domains


uniprot_information_type: SwissProt: Q59H18
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily &  Contains 10 ANK repeats &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O95490
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 1 GPS domain &  Contains 1 olfactomedin-like domain &  Contains 1 SUEL-type lectin domain


uniprot_information_type: SwissProt: P22694
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O00622
uniprot_information:
Belongs to the CCN family &  Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 1 IGFBP N-terminal domain &  Contains 1 TSP type-1 domain &  Contains 1 VWFC domain


uniprot_information_type:
SwissProt: Q9Y371 # An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes# Belongs to the endophilin family &  Contains 1 BAR domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q9Y371 # An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes# Belongs to the endophilin family &  Contains 1 BAR domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q16513 # The C1 domain does not bind the diacylglycerol (DAG)# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 1 protein kinase domain &  Contains 3 REM (Hr1) repeats

uniprot_information:
SwissProt: Q16513 # The C1 domain does not bind the diacylglycerol (DAG)# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 1 protein kinase domain &  Contains 3 REM (Hr1) repeats


uniprot_information_type: SwissProt: O00311
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q58F21 # The two bromodomains are involved in the specific recognition of histone H4 acetylated N-terminus (By similarity)# Contains 2 bromo domains

uniprot_information:
SwissProt: Q58F21 # The two bromodomains are involved in the specific recognition of histone H4 acetylated N-terminus (By similarity)# Contains 2 bromo domains


uniprot_information_type: SwissProt: Q5T0N5
uniprot_information:
Belongs to the FNBP1 family &  Contains 1 FCH domain &  Contains 1 REM (Hr1) repeat &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: P28288
uniprot_information:
Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily &  Contains 1 ABC transmembrane type-1 domain &  Contains 1 ABC transporter domain


uniprot_information_type:
SwissProt: Q9Y3V2 # The RWD domain is required for the sumoylation enhancement activity (By similarity)# Contains 1 RWD domain

uniprot_information:
SwissProt: Q9Y3V2 # The RWD domain is required for the sumoylation enhancement activity (By similarity)# Contains 1 RWD domain


uniprot_information_type:
SwissProt: Q9UNH5 # Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold (By similarity)# Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily

uniprot_information:
SwissProt: Q9UNH5 # Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold (By similarity)# Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily


uniprot_information_type:
SwissProt: P19320 # Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion# Contains 7 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: P19320 # Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion# Contains 7 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: P49591 # Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding (By similarity)# Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

uniprot_information:
SwissProt: P49591 # Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding (By similarity)# Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily


uniprot_information_type: SwissProt: Q9HCU4
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 9 cadherin domains &  Contains 7 EGF-like domains &  Contains 1 GPS domain &  Contains 1 laminin EGF-like domain &  Contains 2 laminin G-like domains


uniprot_information_type:
SwissProt: O43865 # The PEST region is essential for the interaction with ITPR1. The PDZ-binding region is required for maximal interaction with ITPR1 and is also responsible for the IP3-insensitive interaction with ITPR1 (By similarity)# Belongs to the adenosylhomocysteinase family

uniprot_information:
SwissProt: O43865 # The PEST region is essential for the interaction with ITPR1. The PDZ-binding region is required for maximal interaction with ITPR1 and is also responsible for the IP3-insensitive interaction with ITPR1 (By similarity)# Belongs to the adenosylhomocysteinase family


uniprot_information_type:
SwissProt: Q03721 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily

uniprot_information:
SwissProt: Q03721 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily


uniprot_information_type: SwissProt: Q96T37
uniprot_information:
Belongs to the RRM Spen family &  Contains 3 RRM (RNA recognition motif) domains &  Contains 1 SPOC domain


uniprot_information_type: SwissProt: Q86Z02
uniprot_information:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q15431 # Consists of an alpha-helical stretch of 700 AA residues, flanked by N- and C-terminal globular domains. The C-terminal domain has DNA-binding capacity (By similarity) #

uniprot_information:
SwissProt: Q15431 # Consists of an alpha-helical stretch of 700 AA residues, flanked by N- and C-terminal globular domains. The C-terminal domain has DNA-binding capacity (By similarity) #


uniprot_information_type: SwissProt: Q9NYQ3
uniprot_information:
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family &  Contains 1 FMN hydroxy acid dehydrogenase domain


uniprot_information_type: SwissProt: O75396
uniprot_information:
Belongs to the synaptobrevin family &  Contains 1 longin domain &  Contains 1 v-SNARE coiled-coil homology domain


uniprot_information_type:
SwissProt: O75578 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain

uniprot_information:
SwissProt: O75578 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q9Y6X2 # The LXXLL motif is a transcriptional coregulator signature# Belongs to the PIAS family &  Contains 1 PINIT domain &  Contains 1 SAP domain &  Contains 1 SP-RING-type zinc finger

uniprot_information:
SwissProt: Q9Y6X2 # The LXXLL motif is a transcriptional coregulator signature# Belongs to the PIAS family &  Contains 1 PINIT domain &  Contains 1 SAP domain &  Contains 1 SP-RING-type zinc finger


uniprot_information_type:
SwissProt: Q86WJ1 # The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites# Belongs to the SNF2/RAD54 helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 Macro domain

uniprot_information:
SwissProt: Q86WJ1 # The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites# Belongs to the SNF2/RAD54 helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 Macro domain


uniprot_information_type:
SwissProt: Q15047 # The pre-SET, SET and post-SET domains are all required for methyltransferase activity. The 347-amino-acid insertion in the SET domain has no effect on the catalytic activity &  Isoform 2 lacks all domains required for histone methyltransferase activity# Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily &  Contains 1 MBD (methyl-CpG-binding) domain &  Contains 1 post-SET domain &  Contains 1 pre-SET domain &  Contains 1 SET domain &  Contains 2 Tudor domains

uniprot_information:
SwissProt: Q15047 # The pre-SET, SET and post-SET domains are all required for methyltransferase activity. The 347-amino-acid insertion in the SET domain has no effect on the catalytic activity &  Isoform 2 lacks all domains required for histone methyltransferase activity# Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily &  Contains 1 MBD (methyl-CpG-binding) domain &  Contains 1 post-SET domain &  Contains 1 pre-SET domain &  Contains 1 SET domain &  Contains 2 Tudor domains


uniprot_information_type:
SwissProt: P55036 # The 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way# Belongs to the proteasome subunit S5A family &  Contains 2 UIM (ubiquitin-interacting motif) repeats &  Contains 1 VWFA domain

uniprot_information:
SwissProt: P55036 # The 2 UIM motifs are involved in the binding to a multi-ubiquitin chain in a cooperative way# Belongs to the proteasome subunit S5A family &  Contains 2 UIM (ubiquitin-interacting motif) repeats &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q96L92 # The PDZ domain mediates the interaction with DGKZ, PSCDBP and HT4R and is responsible for vesicular localization (By similarity)# Belongs to the sorting nexin family &  Contains 1 PDZ (DHR) domain &  Contains 1 PX (phox homology) domain &  Contains 1 Ras-associating domain

uniprot_information:
SwissProt: Q96L92 # The PDZ domain mediates the interaction with DGKZ, PSCDBP and HT4R and is responsible for vesicular localization (By similarity)# Belongs to the sorting nexin family &  Contains 1 PDZ (DHR) domain &  Contains 1 PX (phox homology) domain &  Contains 1 Ras-associating domain


uniprot_information_type: SwissProt: P16066
uniprot_information:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family &  Contains 1 guanylate cyclase domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P08887 # The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain &  The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding# Belongs to the type I cytokine receptor family. Type 3 subfamily &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: P08887 # The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain &  The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding# Belongs to the type I cytokine receptor family. Type 3 subfamily &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P17787
uniprot_information:
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily


uniprot_information_type:
SwissProt: Q8NFF5 # The molybdenum cofactor biosynthesis protein-like region may not be functional# In the N-terminal section; belongs to the moaB/mog family &  In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily

uniprot_information:
SwissProt: Q8NFF5 # The molybdenum cofactor biosynthesis protein-like region may not be functional# In the N-terminal section; belongs to the moaB/mog family &  In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily


uniprot_information_type:
SwissProt: Q13444 # The cytoplasmic domain interacts with endophilin I and sorting nexin 9 (By similarity) &  Disintegrin domain binds to integrin alphaV-beta3 &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: Q13444 # The cytoplasmic domain interacts with endophilin I and sorting nexin 9 (By similarity) &  Disintegrin domain binds to integrin alphaV-beta3 &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain


uniprot_information_type: SwissProt: Q7Z4K8
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 COS domain &  Contains 1 fibronectin type-III domain &  Contains 2 RING-type zinc fingers


uniprot_information_type:
SwissProt: Q9BVN2 # The RUN domain is necessary for NGF induced nuclear redistribution# Contains 1 RUN domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q9BVN2 # The RUN domain is necessary for NGF induced nuclear redistribution# Contains 1 RUN domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: Q9H3S1
uniprot_information:
Belongs to the semaphorin family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 PSI domain &  Contains 1 Sema domain


uniprot_information_type: SwissProt: Q9GZV7
uniprot_information:
Belongs to the HAPLN family &  Contains 1 Ig-like V-type (immunoglobulin-like) domain &  Contains 2 Link domains


uniprot_information_type: SwissProt: Q96GW7
uniprot_information:
Belongs to the aggrecan/versican proteoglycan family &  Contains 1 C-type lectin domain &  Contains 1 EGF-like domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain &  Contains 2 Link domains &  Contains 1 Sushi (CCP/SCR) domain


uniprot_information_type:
SwissProt: P04629 # The transmembrane domain mediates interaction with KIDINS220 (By similarity) &  The extracellular domain mediates interaction with NGFR (By similarity)# Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 3 LRR (leucine-rich) repeats &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P04629 # The transmembrane domain mediates interaction with KIDINS220 (By similarity) &  The extracellular domain mediates interaction with NGFR (By similarity)# Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 3 LRR (leucine-rich) repeats &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q96J84
uniprot_information:
Belongs to the immunoglobulin superfamily &  Contains 5 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: P41218 # Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1# Contains 1 DAPIN domain &  Contains 1 HIN-200 domain

uniprot_information:
SwissProt: P41218 # Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1# Contains 1 DAPIN domain &  Contains 1 HIN-200 domain


uniprot_information_type:
SwissProt: Q6K0P9 # The HIN-200 domain mediates interaction with MDM2# Belongs to the HIN-200 family &  Contains 1 DAPIN domain &  Contains 1 HIN-200 domain

uniprot_information:
SwissProt: Q6K0P9 # The HIN-200 domain mediates interaction with MDM2# Belongs to the HIN-200 family &  Contains 1 DAPIN domain &  Contains 1 HIN-200 domain


uniprot_information_type:
SwissProt: Q8N126 # The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK (By similarity)# Belongs to the nectin family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q8N126 # The cytoplasmic region mediates interaction with EPB41L1, DLG3, MPP6 and CASK (By similarity)# Belongs to the nectin family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: Q9HBG7
uniprot_information:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 2 Ig-like V-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: P31995 # Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation# Contains 2 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: P31995 # Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation# Contains 2 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: P31994 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 2 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: P31994 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 2 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q9UNI6
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: P18850 # The basic domain functions as a nuclear localization signal &  The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE# Belongs to the bZIP family. ATF subfamily &  Contains 1 bZIP domain

uniprot_information:
SwissProt: P18850 # The basic domain functions as a nuclear localization signal &  The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE# Belongs to the bZIP family. ATF subfamily &  Contains 1 bZIP domain


uniprot_information_type: SwissProt: Q16832
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily &  Contains 1 F5/8 type C domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: P14859
uniprot_information:
Belongs to the POU transcription factor family. Class-2 subfamily &  Contains 1 homeobox DNA-binding domain &  Contains 1 POU-specific domain


uniprot_information_type:
SwissProt: O95297 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the myelin P0 protein family &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: O95297 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the myelin P0 protein family &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: Q9UQP3
uniprot_information:
Belongs to the tenascin family &  Contains 3 EGF-like domains &  Contains 1 fibrinogen C-terminal domain &  Contains 9 fibronectin type-III domains


uniprot_information_type:
SwissProt: Q86X27 # The PH domain mediates binding to phosphatidylinositol 4,5-biphosphate (By similarity)# Contains 1 PH domain &  Contains 1 Ras-GEF domain

uniprot_information:
SwissProt: Q86X27 # The PH domain mediates binding to phosphatidylinositol 4,5-biphosphate (By similarity)# Contains 1 PH domain &  Contains 1 Ras-GEF domain


uniprot_information_type: SwissProt: O00391
uniprot_information:
Belongs to the quiescin-sulfhydryl oxidase (QSOX) family &  Contains 1 ERV/ALR sulfhydryl oxidase domain &  Contains 1 thioredoxin domain


uniprot_information_type:
SwissProt: Q95460 # The alpha-3 region and to a lesser extent the transmembrane and cytosolic domains regulate surface expression# Belongs to the MHC class I family &  Contains 1 Ig-like C1-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q95460 # The alpha-3 region and to a lesser extent the transmembrane and cytosolic domains regulate surface expression# Belongs to the MHC class I family &  Contains 1 Ig-like C1-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q15878 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily &  Contains 1 EF-hand domain

uniprot_information:
SwissProt: Q15878 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily &  Contains 1 EF-hand domain


uniprot_information_type:
SwissProt: Q08211 # The MTAD domain mediates interaction with the RNA polymerase II holoenzyme. The NTD domain is necessary and sufficient for nucleo-cytoplasmic shuttling and interaction with HRMT1L2 and SMN1# Belongs to the DEAD box helicase family. DEAH subfamily &  Contains 2 DRBM (double-stranded RNA-binding) domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain

uniprot_information:
SwissProt: Q08211 # The MTAD domain mediates interaction with the RNA polymerase II holoenzyme. The NTD domain is necessary and sufficient for nucleo-cytoplasmic shuttling and interaction with HRMT1L2 and SMN1# Belongs to the DEAD box helicase family. DEAH subfamily &  Contains 2 DRBM (double-stranded RNA-binding) domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: P11047 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domains VI and IV are globular# Contains 11 laminin EGF-like domains &  Contains 1 laminin IV type A domain &  Contains 1 laminin N-terminal domain

uniprot_information:
SwissProt: P11047 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domains VI and IV are globular# Contains 11 laminin EGF-like domains &  Contains 1 laminin IV type A domain &  Contains 1 laminin N-terminal domain


uniprot_information_type:
SwissProt: Q13753 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domain IV is globular# Contains 8 laminin EGF-like domains &  Contains 1 laminin IV type A domain

uniprot_information:
SwissProt: Q13753 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domain IV is globular# Contains 8 laminin EGF-like domains &  Contains 1 laminin IV type A domain


uniprot_information_type: SwissProt: Q9NZL6
uniprot_information:
Contains 1 N-terminal Ras-GEF domain &  Contains 1 Ras-associating domain &  Contains 1 Ras-GEF domain


uniprot_information_type:
SwissProt: P47712 # The N-terminal C2 domain, by its association with lipid membranes, mediates the regulation of CPLA2 by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+)# Contains 1 C2 domain &  Contains 1 PLA2c domain

uniprot_information:
SwissProt: P47712 # The N-terminal C2 domain, by its association with lipid membranes, mediates the regulation of CPLA2 by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+)# Contains 1 C2 domain &  Contains 1 PLA2c domain


uniprot_information_type: SwissProt: P82279
uniprot_information:
Belongs to the Crumbs protein family &  Contains 19 EGF-like domains &  Contains 3 laminin G-like domains


uniprot_information_type:
SwissProt: P08575 # The first PTPase domain interacts with SKAP1# Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily &  Contains 2 fibronectin type-III domains &  Contains 2 tyrosine-protein phosphatase domains

uniprot_information:
SwissProt: P08575 # The first PTPase domain interacts with SKAP1# Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily &  Contains 2 fibronectin type-III domains &  Contains 2 tyrosine-protein phosphatase domains


uniprot_information_type: SwissProt: O00482
uniprot_information:
Belongs to the nuclear hormone receptor family. NR5 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: Q08AD1 # The CKK domain binds microtubules (By similarity)# Belongs to the CAMSAP1 family &  Contains 1 CH (calponin-homology) domain &  Contains 1 CKK domain

uniprot_information:
SwissProt: Q08AD1 # The CKK domain binds microtubules (By similarity)# Belongs to the CAMSAP1 family &  Contains 1 CH (calponin-homology) domain &  Contains 1 CKK domain


uniprot_information_type:
SwissProt: O75335 # The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS (By similarity)# Belongs to the liprin family. Liprin-alpha subfamily &  Contains 3 SAM (sterile alpha motif) domains

uniprot_information:
SwissProt: O75335 # The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS (By similarity)# Belongs to the liprin family. Liprin-alpha subfamily &  Contains 3 SAM (sterile alpha motif) domains


uniprot_information_type:
SwissProt: P51888 # The basic amino-terminal Arg/Pro-rich binds heparin and heparan sulfate. Binds collagens type I and type II through its leucine-rich repeat domain (By similarity)# Belongs to the small leucine-rich proteoglycan (SLRP) family. Class II subfamily &  Contains 12 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: P51888 # The basic amino-terminal Arg/Pro-rich binds heparin and heparan sulfate. Binds collagens type I and type II through its leucine-rich repeat domain (By similarity)# Belongs to the small leucine-rich proteoglycan (SLRP) family. Class II subfamily &  Contains 12 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: O15151 # Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2# Belongs to the MDM2/MDM4 family &  Contains 1 RanBP2-type zinc finger &  Contains 1 RING-type zinc finger &  Contains 1 SWIB domain

uniprot_information:
SwissProt: O15151 # Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2# Belongs to the MDM2/MDM4 family &  Contains 1 RanBP2-type zinc finger &  Contains 1 RING-type zinc finger &  Contains 1 SWIB domain


uniprot_information_type: SwissProt: O94856
uniprot_information:
Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family &  Contains 5 fibronectin type-III domains &  Contains 6 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q02246
uniprot_information:
Belongs to the immunoglobulin superfamily. Contactin family &  Contains 4 fibronectin type-III domains &  Contains 6 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q14164
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O43781
uniprot_information:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P08174 # The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity)# Belongs to the receptors of complement activation (RCA) family &  Contains 4 Sushi (CCP/SCR) domains

uniprot_information:
SwissProt: P08174 # The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity)# Belongs to the receptors of complement activation (RCA) family &  Contains 4 Sushi (CCP/SCR) domains


uniprot_information_type: SwissProt: P20023
uniprot_information:
Belongs to the receptors of complement activation (RCA) family &  Contains 15 Sushi (CCP/SCR) domains


uniprot_information_type: SwissProt: P17927
uniprot_information:
Belongs to the receptors of complement activation (RCA) family &  Contains 30 Sushi (CCP/SCR) domains


uniprot_information_type:
SwissProt: P15529 # Sushi domains 1 and 2 are required for interaction with human adenovirus B PIV/FIBER protein and with Measles virus H protein. Sushi domains 2 and 3 are required for Herpesvirus 6 binding. Sushi domain 3 is required for Neisseria binding. Sushi domains 3 and 4 are required for interaction with Streptococcus pyogenes M protein and are the most important for interaction with C3b and C4b# Contains 4 Sushi (CCP/SCR) domains

uniprot_information:
SwissProt: P15529 # Sushi domains 1 and 2 are required for interaction with human adenovirus B PIV/FIBER protein and with Measles virus H protein. Sushi domains 2 and 3 are required for Herpesvirus 6 binding. Sushi domain 3 is required for Neisseria binding. Sushi domains 3 and 4 are required for interaction with Streptococcus pyogenes M protein and are the most important for interaction with C3b and C4b# Contains 4 Sushi (CCP/SCR) domains


uniprot_information_type:
SwissProt: Q96NX5 # The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q96NX5 # The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O00463 # The MATH/TRAF domain binds to receptor cytoplasmic domains# Belongs to the TNF receptor-associated factor family. A subfamily &  Contains 1 MATH domain &  Contains 1 RING-type zinc finger &  Contains 2 TRAF-type zinc fingers

uniprot_information:
SwissProt: O00463 # The MATH/TRAF domain binds to receptor cytoplasmic domains# Belongs to the TNF receptor-associated factor family. A subfamily &  Contains 1 MATH domain &  Contains 1 RING-type zinc finger &  Contains 2 TRAF-type zinc fingers


uniprot_information_type:
SwissProt: Q9UMX5 # The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residue at position 82 (By similarity)# Belongs to the cytochrome b5 family. MAPR subfamily &  Contains 1 cytochrome b5 heme-binding domain

uniprot_information:
SwissProt: Q9UMX5 # The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residue at position 82 (By similarity)# Belongs to the cytochrome b5 family. MAPR subfamily &  Contains 1 cytochrome b5 heme-binding domain


uniprot_information_type:
SwissProt: Q96S38 # The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily &  Contains 1 MIT domain &  Contains 2 protein kinase domains &  Contains 1 PX (phox homology) domain

uniprot_information:
SwissProt: Q96S38 # The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily &  Contains 1 MIT domain &  Contains 2 protein kinase domains &  Contains 1 PX (phox homology) domain


uniprot_information_type: SwissProt: Q9P0L2
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily &  Contains 1 KA1 (kinase-associated) domain &  Contains 1 protein kinase domain &  Contains 1 UBA domain


uniprot_information_type:
SwissProt: Q5JRA6 # The proline-rich region (PRD) mediates the interaction with COPII coat subunits Sec23/24 &  Although 2 transmembrane domains are predicted, PubMed:19269366 showed that it only contains one transmembrane domain. The other predicted transmembrane region is probably a hairpin-type region embedded into the membrane, which does not cross the membrane. It is unclear which of the 2 predicted transmembrane regions is the transmembrane or the hairpin-type region# Belongs to the MIA/OTOR family. Tango1 subfamily &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q5JRA6 # The proline-rich region (PRD) mediates the interaction with COPII coat subunits Sec23/24 &  Although 2 transmembrane domains are predicted, PubMed:19269366 showed that it only contains one transmembrane domain. The other predicted transmembrane region is probably a hairpin-type region embedded into the membrane, which does not cross the membrane. It is unclear which of the 2 predicted transmembrane regions is the transmembrane or the hairpin-type region# Belongs to the MIA/OTOR family. Tango1 subfamily &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: P17655
uniprot_information:
Belongs to the peptidase C2 family &  Contains 1 calpain catalytic domain &  Contains 3 EF-hand domains


uniprot_information_type:
SwissProt: P49810 # The PAL motif is required for normal active site conformation (By similarity)# Belongs to the peptidase A22A family

uniprot_information:
SwissProt: P49810 # The PAL motif is required for normal active site conformation (By similarity)# Belongs to the peptidase A22A family


uniprot_information_type: SwissProt: Q8NI60
uniprot_information:
Belongs to the protein kinase superfamily. ADCK protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q5VST9
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 DH (DBL-homology) domain &  Contains 3 fibronectin type-III domains &  Contains 55 Ig-like (immunoglobulin-like) domains &  Contains 1 IQ domain &  Contains 2 PH domains &  Contains 2 protein kinase domains &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q10471 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q10471 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: O15228 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the GPAT/DAPAT family

uniprot_information:
SwissProt: O15228 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the GPAT/DAPAT family


uniprot_information_type:
SwissProt: O00214 # Contains two homologous but distinct carbohydrate-binding domains# Contains 2 galectin domains

uniprot_information:
SwissProt: O00214 # Contains two homologous but distinct carbohydrate-binding domains# Contains 2 galectin domains


uniprot_information_type: SwissProt: P35609
uniprot_information:
Belongs to the alpha-actinin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 2 EF-hand domains &  Contains 4 spectrin repeats


uniprot_information_type:
SwissProt: Q99707 # Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin (By similarity)# Belongs to the vitamin-B12 dependent methionine synthase family &  Contains 1 AdoMet activation domain &  Contains 1 B12-binding domain &  Contains 1 B12-binding N-terminal domain &  Contains 1 Hcy-binding domain &  Contains 1 pterin-binding domain

uniprot_information:
SwissProt: Q99707 # Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin (By similarity)# Belongs to the vitamin-B12 dependent methionine synthase family &  Contains 1 AdoMet activation domain &  Contains 1 B12-binding domain &  Contains 1 B12-binding N-terminal domain &  Contains 1 Hcy-binding domain &  Contains 1 pterin-binding domain


uniprot_information_type: SwissProt: Q92736
uniprot_information:
Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily &  Contains 3 B30.2/SPRY domains &  Contains 2 EF-hand domains &  Contains 5 MIR domains


uniprot_information_type: SwissProt: Q96P20
uniprot_information:
Belongs to the NLRP family &  Contains 1 DAPIN domain &  Contains 7 LRR (leucine-rich) repeats &  Contains 1 NACHT domain


uniprot_information_type: SwissProt: Q92626
uniprot_information:
Belongs to the peroxidase family. XPO subfamily &  Contains 4 Ig-like C2-type (immunoglobulin-like) domains &  Contains 6 LRR (leucine-rich) repeats &  Contains 1 VWFC domain


uniprot_information_type:
SwissProt: Q9ULH0 # The transmembrane domain mediates interaction with NTRK1 (By similarity)# Contains 12 ANK repeats &  Contains 1 KAP NTPase domain

uniprot_information:
SwissProt: Q9ULH0 # The transmembrane domain mediates interaction with NTRK1 (By similarity)# Contains 12 ANK repeats &  Contains 1 KAP NTPase domain


uniprot_information_type:
SwissProt: P78536 # Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity) &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: P78536 # Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Only the catalytic domain is essential to shed TNF and p75 TNFR (By similarity) &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain


uniprot_information_type: SwissProt: O75116
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain &  Contains 1 REM (Hr1) repeat


uniprot_information_type: SwissProt: O95665
uniprot_information:
Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily


uniprot_information_type:
SwissProt: Q96SB8 # The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer (By similarity)# Belongs to the SMC family. SMC6 subfamily

uniprot_information:
SwissProt: Q96SB8 # The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer (By similarity)# Belongs to the SMC family. SMC6 subfamily


uniprot_information_type:
SwissProt: Q15012 # The C-terminal domain is necessary for retention within intracelllular membranes (By similarity)# Belongs to the LAPTM4/LAPTM5 transporter family

uniprot_information:
SwissProt: Q15012 # The C-terminal domain is necessary for retention within intracelllular membranes (By similarity)# Belongs to the LAPTM4/LAPTM5 transporter family


uniprot_information_type:
SwissProt: Q8TB72 # The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs (By similarity)# Contains 1 PUM-HD domain &  Contains 8 pumilio repeats

uniprot_information:
SwissProt: Q8TB72 # The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs (By similarity)# Contains 1 PUM-HD domain &  Contains 8 pumilio repeats


uniprot_information_type: SwissProt: Q9NZM3
uniprot_information:
Contains 1 C2 domain &  Contains 1 DH (DBL-homology) domain &  Contains 2 EF-hand domains &  Contains 2 EH domains &  Contains 1 PH domain &  Contains 5 SH3 domains


uniprot_information_type:
SwissProt: Q9Y6K1 # The PWWP domain is essential for targeting to pericentric heterochromatin# Belongs to the C5-methyltransferase family &  Contains 1 ADD-type zinc finger &  Contains 1 PWWP domain

uniprot_information:
SwissProt: Q9Y6K1 # The PWWP domain is essential for targeting to pericentric heterochromatin# Belongs to the C5-methyltransferase family &  Contains 1 ADD-type zinc finger &  Contains 1 PWWP domain


uniprot_information_type:
SwissProt: O60941 # The coiled coil domain may mediate the interaction with dystrophin# Belongs to the dystrophin family. Dystrobrevin subfamily &  Contains 1 ZZ-type zinc finger

uniprot_information:
SwissProt: O60941 # The coiled coil domain may mediate the interaction with dystrophin# Belongs to the dystrophin family. Dystrobrevin subfamily &  Contains 1 ZZ-type zinc finger


uniprot_information_type:
SwissProt: Q76L83 # Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which may be required for an association with nuclear receptors (By similarity)# Belongs to the Asx family &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: Q76L83 # Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which may be required for an association with nuclear receptors (By similarity)# Belongs to the Asx family &  Contains 1 PHD-type zinc finger


uniprot_information_type: SwissProt: P40939
uniprot_information:
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family &  In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family


uniprot_information_type:
SwissProt: Q99674 # Both EF-hands are required for function (By similarity)# Contains 2 EF-hand domains

uniprot_information:
SwissProt: Q99674 # Both EF-hands are required for function (By similarity)# Contains 2 EF-hand domains


uniprot_information_type: SwissProt: Q9UM73
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily &  Contains 1 LDL-receptor class A domain &  Contains 2 MAM domains &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q96FL9 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q96FL9 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type: SwissProt: P47989
uniprot_information:
Belongs to the xanthine dehydrogenase family &  Contains 1 2Fe-2S ferredoxin-type domain &  Contains 1 FAD-binding PCMH-type domain


uniprot_information_type: SwissProt: P19525
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily &  Contains 2 DRBM (double-stranded RNA-binding) domains &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O94806
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily &  Contains 1 PH domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q6P158
uniprot_information:
Belongs to the DEAD box helicase family. DEAH subfamily &  Contains 1 C3H1-type zinc finger &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 UBA domain


uniprot_information_type: SwissProt: Q07889
uniprot_information:
Contains 1 DH (DBL-homology) domain &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 PH domain &  Contains 1 Ras-GEF domain


uniprot_information_type: SwissProt: Q8IVH8
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 CNH domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: P32418
uniprot_information:
Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily &  Contains 2 Calx-beta domains


uniprot_information_type:
SwissProt: Q8NI22 # Essentially unstructured in the absence of calcium ions. Requires calcium ions for folding# Contains 2 EF-hand domains

uniprot_information:
SwissProt: Q8NI22 # Essentially unstructured in the absence of calcium ions. Requires calcium ions for folding# Contains 2 EF-hand domains


uniprot_information_type: SwissProt: P22888
uniprot_information:
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily &  Contains 7 LRR (leucine-rich) repeats


uniprot_information_type: SwissProt: P23945
uniprot_information:
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily &  Contains 10 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: P35612 # Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region# Belongs to the aldolase class II family. Adducin subfamily

uniprot_information:
SwissProt: P35612 # Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region# Belongs to the aldolase class II family. Adducin subfamily


uniprot_information_type:
SwissProt: Q9BXF6 # Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg(2+) rather than Ca(2+)# Contains 1 C2 domain &  Contains 1 RBD-FIP domain

uniprot_information:
SwissProt: Q9BXF6 # Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg(2+) rather than Ca(2+)# Contains 1 C2 domain &  Contains 1 RBD-FIP domain


uniprot_information_type:
SwissProt: Q9Y3E7 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components# Belongs to the SNF7 family

uniprot_information:
SwissProt: Q9Y3E7 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components# Belongs to the SNF7 family


uniprot_information_type:
SwissProt: P07148 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

uniprot_information:
SwissProt: P07148 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


uniprot_information_type:
SwissProt: Q9NZJ5 # The lumenal domain senses perturbations in protein folding in the ER, probably through reversible interaction with HSPA5/BIP (By similarity)# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q9NZJ5 # The lumenal domain senses perturbations in protein folding in the ER, probably through reversible interaction with HSPA5/BIP (By similarity)# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O75643 # Composed of two similar domains# Belongs to the helicase family. SKI2 subfamily &  Contains 2 helicase ATP-binding domains &  Contains 2 helicase C-terminal domains &  Contains 2 SEC63 domains

uniprot_information:
SwissProt: O75643 # Composed of two similar domains# Belongs to the helicase family. SKI2 subfamily &  Contains 2 helicase ATP-binding domains &  Contains 2 helicase C-terminal domains &  Contains 2 SEC63 domains


uniprot_information_type:
SwissProt: Q9UBZ9 # The C-terminal domain is necessary for protein interactions# Belongs to the DNA polymerase type-Y family &  Contains 1 BRCT domain &  Contains 1 umuC domain

uniprot_information:
SwissProt: Q9UBZ9 # The C-terminal domain is necessary for protein interactions# Belongs to the DNA polymerase type-Y family &  Contains 1 BRCT domain &  Contains 1 umuC domain


uniprot_information_type:
SwissProt: Q14192 # The third LIM zinc-binding mediates interaction with E4F1# Contains 4 LIM zinc-binding domains

uniprot_information:
SwissProt: Q14192 # The third LIM zinc-binding mediates interaction with E4F1# Contains 4 LIM zinc-binding domains


uniprot_information_type:
SwissProt: O15259 # The SH3 domain mediates the stable interaction with Cas (By similarity)# Belongs to the nephrocystin-1 family &  Contains 1 SH3 domain

uniprot_information:
SwissProt: O15259 # The SH3 domain mediates the stable interaction with Cas (By similarity)# Belongs to the nephrocystin-1 family &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: O43683 # The KEN box is required for its ubiquitination and degradation &  BUB1 N-terminal domain directs kinetochore localization and binding to BUB3# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily &  Contains 1 BUB1 N-terminal domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: O43683 # The KEN box is required for its ubiquitination and degradation &  BUB1 N-terminal domain directs kinetochore localization and binding to BUB3# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily &  Contains 1 BUB1 N-terminal domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P01583 # The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function# Belongs to the IL-1 family

uniprot_information:
SwissProt: P01583 # The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function# Belongs to the IL-1 family


uniprot_information_type:
SwissProt: P01584 # The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function# Belongs to the IL-1 family

uniprot_information:
SwissProt: P01584 # The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function# Belongs to the IL-1 family


uniprot_information_type: SwissProt: P19447
uniprot_information:
Belongs to the helicase family. RAD25/XPB subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: Q9Y2U5
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily &  Contains 1 OPR domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9H0E3 # The N-terminus may interact with a transcriptional coactivator &  The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors# Belongs to the SAP130 family

uniprot_information:
SwissProt: Q9H0E3 # The N-terminus may interact with a transcriptional coactivator &  The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors# Belongs to the SAP130 family


uniprot_information_type:
SwissProt: P09848 # The sequence exhibits 4 regions (I-IV) of internal homology; therefore LPH might have evolved by two cycles of partial gene duplication# Belongs to the glycosyl hydrolase 1 family

uniprot_information:
SwissProt: P09848 # The sequence exhibits 4 regions (I-IV) of internal homology; therefore LPH might have evolved by two cycles of partial gene duplication# Belongs to the glycosyl hydrolase 1 family


uniprot_information_type:
SwissProt: P61073 # The amino-terminus is critical for ligand binding. Residues in all four extracellular regions contribute to HIV-1 coreceptor activity# Belongs to the G-protein coupled receptor 1 family

uniprot_information:
SwissProt: P61073 # The amino-terminus is critical for ligand binding. Residues in all four extracellular regions contribute to HIV-1 coreceptor activity# Belongs to the G-protein coupled receptor 1 family


uniprot_information_type: SwissProt: Q9NZR2
uniprot_information:
Belongs to the LDLR family &  Contains 14 EGF-like domains &  Contains 32 LDL-receptor class A domains &  Contains 36 LDL-receptor class B repeats


uniprot_information_type: SwissProt: O60315
uniprot_information:
Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family &  Contains 7 C2H2-type zinc fingers &  Contains 1 homeobox DNA-binding domain


uniprot_information_type:
SwissProt: O75886 # The VHS and UIM domains mediate the interaction with ubiquitinated proteins &  The SH3 domain mediates the interaction with USP8 &  Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Belongs to the STAM family &  Contains 1 ITAM domain &  Contains 1 SH3 domain &  Contains 1 UIM (ubiquitin-interacting motif) repeat &  Contains 1 VHS domain

uniprot_information:
SwissProt: O75886 # The VHS and UIM domains mediate the interaction with ubiquitinated proteins &  The SH3 domain mediates the interaction with USP8 &  Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Belongs to the STAM family &  Contains 1 ITAM domain &  Contains 1 SH3 domain &  Contains 1 UIM (ubiquitin-interacting motif) repeat &  Contains 1 VHS domain


uniprot_information_type:
SwissProt: O75400 # The WW domains are essential for localization to nuclear speckles (By similarity)# Belongs to the PRPF40 family &  Contains 5 FF domains &  Contains 2 WW domains

uniprot_information:
SwissProt: O75400 # The WW domains are essential for localization to nuclear speckles (By similarity)# Belongs to the PRPF40 family &  Contains 5 FF domains &  Contains 2 WW domains


uniprot_information_type: SwissProt: P43354
uniprot_information:
Belongs to the nuclear hormone receptor family. NR4 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type: SwissProt: Q04771
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily &  Contains 1 GS domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9UIF8
uniprot_information:
Belongs to the WAL family &  Contains 1 bromo domain &  Contains 1 DDT domain &  Contains 1 MBD (methyl-CpG-binding) domain &  Contains 1 PHD-type zinc finger


uniprot_information_type: SwissProt: O60449
uniprot_information:
Contains 10 C-type lectin domains &  Contains 1 fibronectin type-II domain &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: Q13018 # C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B &  The endocytosis signal probably mediates endocytosis via clathrin-coated pits (By similarity)# Contains 8 C-type lectin domains &  Contains 1 fibronectin type-II domain &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q13018 # C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B &  The endocytosis signal probably mediates endocytosis via clathrin-coated pits (By similarity)# Contains 8 C-type lectin domains &  Contains 1 fibronectin type-II domain &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: P27487 # The extracellular cysteine-rich region is necessary for association with collagen, dimer formation and optimal dipeptidyl peptidase activity# Belongs to the peptidase S9B family. DPPIV subfamily

uniprot_information:
SwissProt: P27487 # The extracellular cysteine-rich region is necessary for association with collagen, dimer formation and optimal dipeptidyl peptidase activity# Belongs to the peptidase S9B family. DPPIV subfamily


uniprot_information_type: SwissProt: Q9BYX4
uniprot_information:
Belongs to the helicase family &  Contains 2 CARD domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q14449 # The PH domain binds relatively non-specifically and with low affinity to several phosphoinositides, the best binder being PI(3,4,5)P3# Belongs to the GRB7/10/14 family &  Contains 1 PH domain &  Contains 1 Ras-associating domain &  Contains 1 SH2 domain

uniprot_information:
SwissProt: Q14449 # The PH domain binds relatively non-specifically and with low affinity to several phosphoinositides, the best binder being PI(3,4,5)P3# Belongs to the GRB7/10/14 family &  Contains 1 PH domain &  Contains 1 Ras-associating domain &  Contains 1 SH2 domain


uniprot_information_type:
SwissProt: Q9NY46 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily &  Contains 1 IQ domain

uniprot_information:
SwissProt: Q9NY46 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily &  Contains 1 IQ domain


uniprot_information_type:
SwissProt: Q14435 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q14435 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: P35498 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.1/SCN1A subfamily &  Contains 1 IQ domain

uniprot_information:
SwissProt: P35498 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.1/SCN1A subfamily &  Contains 1 IQ domain


uniprot_information_type:
SwissProt: Q15858 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily &  Contains 1 IQ domain

uniprot_information:
SwissProt: Q15858 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily &  Contains 1 IQ domain


uniprot_information_type:
SwissProt: Q01118 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily

uniprot_information:
SwissProt: Q01118 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily


uniprot_information_type:
SwissProt: Q9UEW8 # PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins# Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q9UEW8 # PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins# Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O95342 # Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain# Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily &  Contains 2 ABC transmembrane type-1 domains &  Contains 2 ABC transporter domains

uniprot_information:
SwissProt: O95342 # Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain# Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily &  Contains 2 ABC transmembrane type-1 domains &  Contains 2 ABC transporter domains


uniprot_information_type: SwissProt: P98164
uniprot_information:
Belongs to the LDLR family &  Contains 17 EGF-like domains &  Contains 36 LDL-receptor class A domains &  Contains 37 LDL-receptor class B repeats


uniprot_information_type:
SwissProt: O43516 # Binds to WAS within the N-terminal region 170, at a site distinct from the CDC42-binding site# Belongs to the verprolin family &  Contains 1 WH2 domain

uniprot_information:
SwissProt: O43516 # Binds to WAS within the N-terminal region 170, at a site distinct from the CDC42-binding site# Belongs to the verprolin family &  Contains 1 WH2 domain


uniprot_information_type: SwissProt: P15336
uniprot_information:
Belongs to the bZIP family. ATF subfamily &  Contains 1 bZIP domain &  Contains 1 C2H2-type zinc finger


uniprot_information_type:
SwissProt: Q16236 # Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus# Belongs to the bZIP family. CNC subfamily &  Contains 1 bZIP domain

uniprot_information:
SwissProt: Q16236 # Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus# Belongs to the bZIP family. CNC subfamily &  Contains 1 bZIP domain


uniprot_information_type:
SwissProt: Q9HCR9 # The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP leading to stimulate the enzyme activity# Belongs to the cyclic nucleotide phosphodiesterase family &  Contains 2 GAF domains

uniprot_information:
SwissProt: Q9HCR9 # The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP leading to stimulate the enzyme activity# Belongs to the cyclic nucleotide phosphodiesterase family &  Contains 2 GAF domains


uniprot_information_type:
SwissProt: O75569 # Self-association may occur via interactions between DRBM domains as follows: DRBM 1/DRBM 1, DRBM 1/DRBM 2, DRBM 2/DRBM 2 or DRBM 3/DRBM3# Belongs to the PRKRA family &  Contains 3 DRBM (double-stranded RNA-binding) domains

uniprot_information:
SwissProt: O75569 # Self-association may occur via interactions between DRBM domains as follows: DRBM 1/DRBM 1, DRBM 1/DRBM 2, DRBM 2/DRBM 2 or DRBM 3/DRBM3# Belongs to the PRKRA family &  Contains 3 DRBM (double-stranded RNA-binding) domains


uniprot_information_type:
SwissProt: Q8WZ42 # ZIS1 and ZIS5 regions contain multiple SPXR consensus sites for ERK- and CDK-like protein kinases as well as multiple SP motifs. ZIS1 could adopt a closed conformation which would block the TCAP-binding site &  The PEVK region may serve as an entropic spring of a chain of structural folds and may also be an interaction site to other myofilament proteins to form interfilament connectivity in the sarcomere# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 132 fibronectin type-III domains &  Contains 152 Ig-like (immunoglobulin-like) domains &  Contains 19 Kelch repeats &  Contains 1 protein kinase domain &  Contains 17 RCC1 repeats &  Contains 14 TPR repeats &  Contains 15 WD repeats

uniprot_information:
SwissProt: Q8WZ42 # ZIS1 and ZIS5 regions contain multiple SPXR consensus sites for ERK- and CDK-like protein kinases as well as multiple SP motifs. ZIS1 could adopt a closed conformation which would block the TCAP-binding site &  The PEVK region may serve as an entropic spring of a chain of structural folds and may also be an interaction site to other myofilament proteins to form interfilament connectivity in the sarcomere# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 132 fibronectin type-III domains &  Contains 152 Ig-like (immunoglobulin-like) domains &  Contains 19 Kelch repeats &  Contains 1 protein kinase domain &  Contains 17 RCC1 repeats &  Contains 14 TPR repeats &  Contains 15 WD repeats


uniprot_information_type:
SwissProt: Q92765 # The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the secreted frizzled-related protein (sFRP) family &  Contains 1 FZ (frizzled) domain &  Contains 1 NTR domain

uniprot_information:
SwissProt: Q92765 # The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the secreted frizzled-related protein (sFRP) family &  Contains 1 FZ (frizzled) domain &  Contains 1 NTR domain


uniprot_information_type:
SwissProt: P10646 # This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa# Contains 3 BPTI/Kunitz inhibitor domains

uniprot_information:
SwissProt: P10646 # This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa# Contains 3 BPTI/Kunitz inhibitor domains


uniprot_information_type: SwissProt: P05997
uniprot_information:
Belongs to the fibrillar collagen family &  Contains 1 fibrillar collagen NC1 domain &  Contains 1 VWFC domain


uniprot_information_type:
SwissProt: Q8WXX0 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family

uniprot_information:
SwissProt: Q8WXX0 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family


uniprot_information_type: SwissProt: O94768
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9UPW6
uniprot_information:
Belongs to the CUT homeobox family &  Contains 2 CUT DNA-binding domains &  Contains 1 homeobox DNA-binding domain


uniprot_information_type:
SwissProt: O75840 # The acidic N-terminal part may favor interaction with the basic domain of transcription factors# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 3 C2H2-type zinc fingers

uniprot_information:
SwissProt: O75840 # The acidic N-terminal part may favor interaction with the basic domain of transcription factors# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 3 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q13467 # The PDZ-binding motif mediates interaction with GOPC (By similarity) &  Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain

uniprot_information:
SwissProt: Q13467 # The PDZ-binding motif mediates interaction with GOPC (By similarity) &  Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain


uniprot_information_type:
SwissProt: P07320 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains

uniprot_information:
SwissProt: P07320 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains


uniprot_information_type:
SwissProt: P07315 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains

uniprot_information:
SwissProt: P07315 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains


uniprot_information_type:
SwissProt: P07316 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains

uniprot_information:
SwissProt: P07316 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains


uniprot_information_type:
SwissProt: P11844 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains

uniprot_information:
SwissProt: P11844 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains


uniprot_information_type: SwissProt: Q15303
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q86UK0 # Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain (By similarity)# Belongs to the ABC transporter superfamily. ABCA family &  Contains 2 ABC transporter domains

uniprot_information:
SwissProt: Q86UK0 # Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain (By similarity)# Belongs to the ABC transporter superfamily. ABCA family &  Contains 2 ABC transporter domains


uniprot_information_type: SwissProt: P02751
uniprot_information:
Contains 12 fibronectin type-I domains &  Contains 2 fibronectin type-II domains &  Contains 16 fibronectin type-III domains


uniprot_information_type: SwissProt: Q9HBL0
uniprot_information:
Contains 1 C2 tensin-type domain &  Contains 1 phosphatase tensin-type domain &  Contains 1 SH2 domain


uniprot_information_type:
SwissProt: Q96BH1 # The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination# Contains 1 RING-type zinc finger &  Contains 1 RWD domain

uniprot_information:
SwissProt: Q96BH1 # The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination# Contains 1 RING-type zinc finger &  Contains 1 RWD domain


uniprot_information_type:
SwissProt: P53672 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains

uniprot_information:
SwissProt: P53672 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains


uniprot_information_type: SwissProt: Q9NP58
uniprot_information:
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily &  Contains 1 ABC transmembrane type-1 domain &  Contains 1 ABC transporter domain


uniprot_information_type: SwissProt: Q16849
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: P54764 # The protein kinase domain mediates interaction with NGEF/ephexin-1 (By similarity)# Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily &  Contains 2 fibronectin type-III domains &  Contains 1 protein kinase domain &  Contains 1 SAM (sterile alpha motif) domain

uniprot_information:
SwissProt: P54764 # The protein kinase domain mediates interaction with NGEF/ephexin-1 (By similarity)# Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily &  Contains 2 fibronectin type-III domains &  Contains 1 protein kinase domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: Q96BY6 # The DHR-2 domain may mediate some GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q96BY6 # The DHR-2 domain may mediate some GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: P53420 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain

uniprot_information:
SwissProt: P53420 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain


uniprot_information_type: SwissProt: Q14669
uniprot_information:
Belongs to the UPL family. K-HECT subfamily &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 1 WWE domain


uniprot_information_type: SwissProt: Q9HB58
uniprot_information:
Contains 1 bromo domain &  Contains 1 HSR domain &  Contains 1 PHD-type zinc finger &  Contains 1 SAND domain


uniprot_information_type: SwissProt: P12111
uniprot_information:
Belongs to the type VI collagen family &  Contains 1 BPTI/Kunitz inhibitor domain &  Contains 5 collagen-like domains &  Contains 1 fibronectin type-III domain &  Contains 16 LRR (leucine-rich) repeats &  Contains 12 VWFA domains


uniprot_information_type:
SwissProt: P56524 # The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm# Belongs to the histone deacetylase family. Type 2 subfamily

uniprot_information:
SwissProt: P56524 # The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm# Belongs to the histone deacetylase family. Type 2 subfamily


uniprot_information_type: SwissProt: Q96RG2
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 2 PAS (PER-ARNT-SIM) domains &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O00506
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9NY99 # The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity)# Belongs to the syntrophin family &  Contains 1 PDZ (DHR) domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q9NY99 # The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity)# Belongs to the syntrophin family &  Contains 1 PDZ (DHR) domain &  Contains 1 PH domain


uniprot_information_type: SwissProt: P07202
uniprot_information:
Belongs to the peroxidase family. XPO subfamily &  Contains 1 EGF-like domain &  Contains 1 Sushi (CCP/SCR) domain


uniprot_information_type: SwissProt: Q9BWP8
uniprot_information:
Belongs to the COLEC10/COLEC11 family &  Contains 1 C-type lectin domain &  Contains 1 collagen-like domain


uniprot_information_type: SwissProt: P50876
uniprot_information:
Belongs to the RBR family. RNF144 subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers


uniprot_information_type:
SwissProt: O43150 # The conserved Arg-464 in the Arf-GAP domain probably becomes part of the active site of bound small GTPases and is necessary for GTP hydrolysis# Contains 2 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 PH domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: O43150 # The conserved Arg-464 in the Arf-GAP domain probably becomes part of the active site of bound small GTPases and is necessary for GTP hydrolysis# Contains 2 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 PH domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q9H3M0 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily

uniprot_information:
SwissProt: Q9H3M0 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily


uniprot_information_type:
SwissProt: Q14693 # Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL), a transcriptional binding motif, which mediates interaction with PPARA (By similarity) &  Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity (By similarity)# Belongs to the lipin family

uniprot_information:
SwissProt: Q14693 # Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL), a transcriptional binding motif, which mediates interaction with PPARA (By similarity) &  Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity (By similarity)# Belongs to the lipin family


uniprot_information_type: SwissProt: Q92519
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q92499
uniprot_information:
Belongs to the DEAD box helicase family. DDX1 subfamily &  Contains 1 B30.2/SPRY domain &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q9BQ31 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily

uniprot_information:
SwissProt: Q9BQ31 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily


uniprot_information_type:
SwissProt: Q15788 # The C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity &  Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in vitro# Belongs to the SRC/p160 nuclear receptor coactivator family &  Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 PAS (PER-ARNT-SIM) domain

uniprot_information:
SwissProt: Q15788 # The C-terminal (1107-1441) part mediates the histone acetyltransferase (HAT) activity &  Contains 7 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. LXXLL motifs 3, 4 and 5 are essential for the association with nuclear receptors. LXXLL motif 7, which is not present in isoform 2, increases the affinity for steroid receptors in vitro# Belongs to the SRC/p160 nuclear receptor coactivator family &  Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 PAS (PER-ARNT-SIM) domain


uniprot_information_type:
SwissProt: P49450 # The CATD (CENPA targeting domain) region is responsible for the more compact structure of nucleosomes containing CENPA and is necessary and sufficient to mediate the localization into centromeres# Belongs to the histone H3 family

uniprot_information:
SwissProt: P49450 # The CATD (CENPA targeting domain) region is responsible for the more compact structure of nucleosomes containing CENPA and is necessary and sufficient to mediate the localization into centromeres# Belongs to the histone H3 family


uniprot_information_type:
SwissProt: Q9UPY8 # Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1# Belongs to the MAPRE family &  Contains 1 CH (calponin-homology) domain &  Contains 1 EB1 C-terminal domain

uniprot_information:
SwissProt: Q9UPY8 # Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1# Belongs to the MAPRE family &  Contains 1 CH (calponin-homology) domain &  Contains 1 EB1 C-terminal domain


uniprot_information_type: SwissProt: P27708
uniprot_information:
In the central section; belongs to the DHOase family &  Contains 2 ATP-grasp domains &  Contains 1 glutamine amidotransferase type-1 domain


uniprot_information_type:
SwissProt: Q15036 # The PX domain is required for association with endosomes# Belongs to the sorting nexin family &  Contains 1 PX (phox homology) domain &  Contains 1 Ras-associating domain

uniprot_information:
SwissProt: Q15036 # The PX domain is required for association with endosomes# Belongs to the sorting nexin family &  Contains 1 PX (phox homology) domain &  Contains 1 Ras-associating domain


uniprot_information_type:
SwissProt: Q9UHY1 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q9UHY1 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9NXR7 # Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin# Belongs to the BRE family

uniprot_information:
SwissProt: Q9NXR7 # Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin# Belongs to the BRE family


uniprot_information_type:
SwissProt: Q9NZN3 # The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity)# Contains 1 EF-hand domain &  Contains 1 EH domain

uniprot_information:
SwissProt: Q9NZN3 # The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity)# Contains 1 EF-hand domain &  Contains 1 EH domain


uniprot_information_type:
SwissProt: Q14766 # Associates covalently with small latent TGF-beta complex via domain TB 3# Belongs to the LTBP family &  Contains 18 EGF-like domains &  Contains 4 TB (TGF-beta binding) domains

uniprot_information:
SwissProt: Q14766 # Associates covalently with small latent TGF-beta complex via domain TB 3# Belongs to the LTBP family &  Contains 18 EGF-like domains &  Contains 4 TB (TGF-beta binding) domains


uniprot_information_type: SwissProt: Q8IV61
uniprot_information:
Belongs to the RASGRP family &  Contains 2 EF-hand domains &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 Ras-GEF domain


uniprot_information_type:
SwissProt: Q02156 # The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q02156 # The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O75159 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SH2 domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: O75159 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SH2 domain &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q01082
uniprot_information:
Belongs to the spectrin family &  Contains 2 CH (calponin-homology) domains &  Contains 1 PH domain &  Contains 17 spectrin repeats


uniprot_information_type: SwissProt: P62979
uniprot_information:
In the N-terminal section; belongs to the ubiquitin family &  In the C-terminal section; belongs to the ribosomal protein S27Ae family &  Contains 1 ubiquitin-like domain


uniprot_information_type: SwissProt: Q86Y07
uniprot_information:
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q6ULP2 # The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity)#

uniprot_information:
SwissProt: Q6ULP2 # The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity)#


uniprot_information_type:
SwissProt: Q9H6X2 # Binding to PA seems to be effected through the VWA domain# Belongs to the ATR family &  Contains 1 VWFA domain

uniprot_information:
SwissProt: Q9H6X2 # Binding to PA seems to be effected through the VWA domain# Belongs to the ATR family &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: P09525 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats

uniprot_information:
SwissProt: P09525 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats


uniprot_information_type:
SwissProt: P15313 # The PDZ-binding motif mediates interactions with SLC9A3R1 and SCL4A7# Belongs to the ATPase alpha/beta chains family

uniprot_information:
SwissProt: P15313 # The PDZ-binding motif mediates interactions with SLC9A3R1 and SCL4A7# Belongs to the ATPase alpha/beta chains family


uniprot_information_type:
SwissProt: O75923 # The C2 domain 1 associates with lipid membranes in a calcium-dependent manner# Belongs to the ferlin family &  Contains 5 C2 domains

uniprot_information:
SwissProt: O75923 # The C2 domain 1 associates with lipid membranes in a calcium-dependent manner# Belongs to the ferlin family &  Contains 5 C2 domains


uniprot_information_type:
SwissProt: O95630 # The JAMM motif is essential for the protease activity (By similarity)# Belongs to the peptidase M67C family &  Contains 1 MPN (JAB/Mov34) domain

uniprot_information:
SwissProt: O95630 # The JAMM motif is essential for the protease activity (By similarity)# Belongs to the peptidase M67C family &  Contains 1 MPN (JAB/Mov34) domain


uniprot_information_type:
SwissProt: O43464 # The mature N-terminus is involved in the interaction with XIAP &  The PDZ domain mediates interaction with MXI2# Belongs to the peptidase S1B family &  Contains 1 PDZ (DHR) domain

uniprot_information:
SwissProt: O43464 # The mature N-terminus is involved in the interaction with XIAP &  The PDZ domain mediates interaction with MXI2# Belongs to the peptidase S1B family &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: Q99704 # The PTB domain mediates receptor interaction# Belongs to the DOK family. Type A subfamily &  Contains 1 IRS-type PTB domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q99704 # The PTB domain mediates receptor interaction# Belongs to the DOK family. Type A subfamily &  Contains 1 IRS-type PTB domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: P52789 # The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose and Gluc-6-P molecule# Belongs to the hexokinase family

uniprot_information:
SwissProt: P52789 # The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose and Gluc-6-P molecule# Belongs to the hexokinase family


uniprot_information_type:
SwissProt: Q9C0G6 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family

uniprot_information:
SwissProt: Q9C0G6 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family


uniprot_information_type:
SwissProt: Q9HCS4 # The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1 (By similarity)# Belongs to the TCF/LEF family &  Contains 1 HMG box DNA-binding domain

uniprot_information:
SwissProt: Q9HCS4 # The putative Groucho interaction domain between the N-terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1 (By similarity)# Belongs to the TCF/LEF family &  Contains 1 HMG box DNA-binding domain


uniprot_information_type:
SwissProt: Q9Y4C1 # The JmjC domain and the C6-type zinc-finger are required for the demethylation activity &  Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity)# Belongs to the JHDM2 histone demethylase family &  Contains 1 JmjC domain

uniprot_information:
SwissProt: Q9Y4C1 # The JmjC domain and the C6-type zinc-finger are required for the demethylation activity &  Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity)# Belongs to the JHDM2 histone demethylase family &  Contains 1 JmjC domain


uniprot_information_type:
SwissProt: P43403 # The SH2 domains bind to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z and the non-canonical phosphorylated tyrosine-based activation motif (TAM) of RHOH (By similarity)# Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily &  Contains 1 protein kinase domain &  Contains 2 SH2 domains

uniprot_information:
SwissProt: P43403 # The SH2 domains bind to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z and the non-canonical phosphorylated tyrosine-based activation motif (TAM) of RHOH (By similarity)# Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily &  Contains 1 protein kinase domain &  Contains 2 SH2 domains


uniprot_information_type: SwissProt: Q16281
uniprot_information:
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA3 subfamily &  Contains 1 cyclic nucleotide-binding domain


uniprot_information_type: SwissProt: P27930
uniprot_information:
Belongs to the interleukin-1 receptor family &  Contains 3 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: P14778
uniprot_information:
Belongs to the interleukin-1 receptor family &  Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 TIR domain


uniprot_information_type: SwissProt: O95256
uniprot_information:
Belongs to the interleukin-1 receptor family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 TIR domain


uniprot_information_type:
SwissProt: P49792 # Contains F-X-F-G repeats# Contains 1 PPIase cyclophilin-type domain &  Contains 4 RanBD1 domains &  Contains 8 RanBP2-type zinc fingers &  Contains 1 TPR repeat

uniprot_information:
SwissProt: P49792 # Contains F-X-F-G repeats# Contains 1 PPIase cyclophilin-type domain &  Contains 4 RanBD1 domains &  Contains 8 RanBP2-type zinc fingers &  Contains 1 TPR repeat


uniprot_information_type:
SwissProt: O43521 # The BH3 motif is required for Bcl-2 binding and cytotoxicity# Belongs to the Bcl-2 family

uniprot_information:
SwissProt: O43521 # The BH3 motif is required for Bcl-2 binding and cytotoxicity# Belongs to the Bcl-2 family


uniprot_information_type: SwissProt: Q12866
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily &  Contains 2 fibronectin type-III domains &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8WUM9 # Region A confers human cells susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection# Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family

uniprot_information:
SwissProt: Q8WUM9 # Region A confers human cells susceptibility to infection by Gibbon Ape Leukemia Virus (GaLV) and Feline leukemia virus subgroup B (FeLV-B). Substitution of Human SLC20A1 region A by region A of murine SLC20A1 prevents viral infection# Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family


uniprot_information_type: SwissProt: Q9NVP1
uniprot_information:
Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: P29074
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily &  Contains 1 FERM domain &  Contains 1 PDZ (DHR) domain &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type: SwissProt: P04070
uniprot_information:
Belongs to the peptidase S1 family &  Contains 2 EGF-like domains &  Contains 1 Gla (gamma-carboxy-glutamate) domain &  Contains 1 peptidase S1 domain


uniprot_information_type: SwissProt: Q6PIF6
uniprot_information:
Contains 2 FERM domains &  Contains 6 IQ domains &  Contains 1 myosin head-like domain &  Contains 3 MyTH4 domains &  Contains 2 SH3 domains


uniprot_information_type:
SwissProt: Q9NYU2 # The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects (By similarity)# Belongs to the glycosyltransferase 8 family

uniprot_information:
SwissProt: Q9NYU2 # The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects (By similarity)# Belongs to the glycosyltransferase 8 family


uniprot_information_type:
SwissProt: Q92575 # The UBX domain is required for interaction with VCP &  The intramembrane domain also contains the signal for ER targeting# Contains 1 UBX domain

uniprot_information:
SwissProt: Q92575 # The UBX domain is required for interaction with VCP &  The intramembrane domain also contains the signal for ER targeting# Contains 1 UBX domain


uniprot_information_type:
SwissProt: Q53QZ3 # The PH domain is required for localization to the membrane# Contains 1 PH domain &  Contains 1 Rho-GAP domain

uniprot_information:
SwissProt: Q53QZ3 # The PH domain is required for localization to the membrane# Contains 1 PH domain &  Contains 1 Rho-GAP domain


uniprot_information_type: SwissProt: P27037
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O60282 # Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles# Belongs to the kinesin-like protein family. Kinesin subfamily &  Contains 1 kinesin-motor domain

uniprot_information:
SwissProt: O60282 # Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles# Belongs to the kinesin-like protein family. Kinesin subfamily &  Contains 1 kinesin-motor domain


uniprot_information_type: SwissProt: P43304
uniprot_information:
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family &  Contains 2 EF-hand domains


uniprot_information_type:
SwissProt: Q9H992 # The RING-CH-type zinc finger domain is required for E3 ligase activity# Contains 1 RING-CH-type zinc finger

uniprot_information:
SwissProt: Q9H992 # The RING-CH-type zinc finger domain is required for E3 ligase activity# Contains 1 RING-CH-type zinc finger


uniprot_information_type:
SwissProt: Q99250 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily &  Contains 1 IQ domain

uniprot_information:
SwissProt: Q99250 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily &  Contains 1 IQ domain


uniprot_information_type:
SwissProt: Q13427 # The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II# Contains 1 PPIase cyclophilin-type domain

uniprot_information:
SwissProt: Q13427 # The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II# Contains 1 PPIase cyclophilin-type domain


uniprot_information_type:
SwissProt: Q8WZA2 # The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2 &  The DEP domain is involved in membrane localization independent from regulation by cAMP (By similarity)# Contains 2 cyclic nucleotide-binding domains &  Contains 1 DEP domain &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 Ras-GEF domain

uniprot_information:
SwissProt: Q8WZA2 # The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2 &  The DEP domain is involved in membrane localization independent from regulation by cAMP (By similarity)# Contains 2 cyclic nucleotide-binding domains &  Contains 1 DEP domain &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 Ras-GEF domain


uniprot_information_type: SwissProt: Q9NYL2
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily &  Contains 1 protein kinase domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: P13612 # The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats

uniprot_information:
SwissProt: P13612 # The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats


uniprot_information_type:
SwissProt: Q13506 # The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization &  The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression# Belongs to the NAB family

uniprot_information:
SwissProt: Q13506 # The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization &  The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression# Belongs to the NAB family


uniprot_information_type: SwissProt: Q15111
uniprot_information:
Contains 1 C2 domain &  Contains 1 PH domain &  Contains 1 PI-PLC X-box domain &  Contains 1 PI-PLC Y-box domain


uniprot_information_type:
SwissProt: O15519 # The caspase domain lacks the active sites residues involved in catalysis# Belongs to the peptidase C14A family &  Contains 2 DED (death effector) domains

uniprot_information:
SwissProt: O15519 # The caspase domain lacks the active sites residues involved in catalysis# Belongs to the peptidase C14A family &  Contains 2 DED (death effector) domains


uniprot_information_type:
SwissProt: Q14790 # Isoform 9 contains a N-terminal extension that is required for interaction with the BCAP31 complex# Belongs to the peptidase C14A family &  Contains 2 DED (death effector) domains

uniprot_information:
SwissProt: Q14790 # Isoform 9 contains a N-terminal extension that is required for interaction with the BCAP31 complex# Belongs to the peptidase C14A family &  Contains 2 DED (death effector) domains


uniprot_information_type:
SwissProt: O75084 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain

uniprot_information:
SwissProt: O75084 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain


uniprot_information_type: SwissProt: Q9NYB9
uniprot_information:
Belongs to the ABI family &  Contains 1 SH3 domain &  Contains 1 t-SNARE coiled-coil homology domain


uniprot_information_type: SwissProt: O60462
uniprot_information:
Belongs to the neuropilin family &  Contains 2 CUB domains &  Contains 2 F5/8 type C domains &  Contains 1 MAM domain


uniprot_information_type:
SwissProt: O75077 # A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: O75077 # A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain


uniprot_information_type:
SwissProt: P31327 # The type-1 glutamine amidotransferase domain is defective# Contains 2 ATP-grasp domains &  Contains 1 glutamine amidotransferase type-1 domain

uniprot_information:
SwissProt: P31327 # The type-1 glutamine amidotransferase domain is defective# Contains 2 ATP-grasp domains &  Contains 1 glutamine amidotransferase type-1 domain


uniprot_information_type:
SwissProt: P31939 # The IMP cyclohydrolase activity resides in the N-terminal region# Belongs to the purH family

uniprot_information:
SwissProt: P31939 # The IMP cyclohydrolase activity resides in the N-terminal region# Belongs to the purH family


uniprot_information_type:
SwissProt: P13010 # The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage# Belongs to the ku80 family &  Contains 1 Ku domain

uniprot_information:
SwissProt: P13010 # The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage# Belongs to the ku80 family &  Contains 1 Ku domain


uniprot_information_type: SwissProt: Q9NZC9
uniprot_information:
Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily &  Contains 2 HARP domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: P18065 # The C-terminus is required for IGF-binding and growth inhibition# Contains 1 IGFBP N-terminal domain &  Contains 1 thyroglobulin type-1 domain

uniprot_information:
SwissProt: P18065 # The C-terminus is required for IGF-binding and growth inhibition# Contains 1 IGFBP N-terminal domain &  Contains 1 thyroglobulin type-1 domain


uniprot_information_type:
SwissProt: P09327 # Consists of a large core fragment, the N-terminal portion, and a small headpiece, the C-terminal portion. The headpiece binds F-actin strongly in both the presence and absence of calcium# Belongs to the villin/gelsolin family &  Contains 6 gelsolin-like repeats &  Contains 1 HP (headpiece) domain

uniprot_information:
SwissProt: P09327 # Consists of a large core fragment, the N-terminal portion, and a small headpiece, the C-terminal portion. The headpiece binds F-actin strongly in both the presence and absence of calcium# Belongs to the villin/gelsolin family &  Contains 6 gelsolin-like repeats &  Contains 1 HP (headpiece) domain


uniprot_information_type: SwissProt: Q15772
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 2 fibronectin type-III domains &  Contains 9 Ig-like (immunoglobulin-like) domains &  Contains 2 protein kinase domains


uniprot_information_type:
SwissProt: Q01955 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain

uniprot_information:
SwissProt: Q01955 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain


uniprot_information_type:
SwissProt: P52594 # Contains FG repeats. The FG repeat region is required for acting as a cofactor of HIV-1 Rev# Contains 1 Arf-GAP domain

uniprot_information:
SwissProt: P52594 # Contains FG repeats. The FG repeat region is required for acting as a cofactor of HIV-1 Rev# Contains 1 Arf-GAP domain


uniprot_information_type:
SwissProt: P23497 # The HSR domain is important for the nuclear body targeting as well as for the dimerization &  Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Contains 2 HMG box DNA-binding domains &  Contains 1 HSR domain &  Contains 1 SAND domain

uniprot_information:
SwissProt: P23497 # The HSR domain is important for the nuclear body targeting as well as for the dimerization &  Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Contains 2 HMG box DNA-binding domains &  Contains 1 HSR domain &  Contains 1 SAND domain


uniprot_information_type: SwissProt: Q07001
uniprot_information:
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Delta/CHRND sub-subfamily


uniprot_information_type: SwissProt: P07510
uniprot_information:
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub-subfamily


uniprot_information_type:
SwissProt: Q92835 # The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for tyrosine phosphorylation (By similarity) &  The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain (By similarity)# Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family &  Contains 1 SH2 domain

uniprot_information:
SwissProt: Q92835 # The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for tyrosine phosphorylation (By similarity) &  The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain (By similarity)# Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family &  Contains 1 SH2 domain


uniprot_information_type: SwissProt: Q16760
uniprot_information:
Belongs to the eukaryotic diacylglycerol kinase family &  Contains 1 DAGKc domain &  Contains 1 PH domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: Q9P0V3 # The SH3 domain mediates localization to the clathrin-coated pits and vesicles. The SH3 domain mediates interaction with DNM2 and the cytoplasmic part of TFRC with a lower affinity# Contains 1 SH3 domain

uniprot_information:
SwissProt: Q9P0V3 # The SH3 domain mediates localization to the clathrin-coated pits and vesicles. The SH3 domain mediates interaction with DNM2 and the cytoplasmic part of TFRC with a lower affinity# Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q9UPQ3 # The PH domain mediates AP-3 binding# Belongs to the centaurin gamma-like family &  Contains 2 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q9UPQ3 # The PH domain mediates AP-3 binding# Belongs to the centaurin gamma-like family &  Contains 2 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q9Y576 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q9Y576 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q8TER0
uniprot_information:
Contains 15 EGF-like domains &  Contains 3 fibronectin type-III domains &  Contains 2 follistatin-like domains &  Contains 1 NIDO domain &  Contains 1 Sushi (CCP/SCR) domain


uniprot_information_type:
SwissProt: Q01344 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 5 subfamily

uniprot_information:
SwissProt: Q01344 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 5 subfamily


uniprot_information_type:
SwissProt: Q14012 # The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q14012 # The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: P04049
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain &  Contains 1 RBD (Ras-binding) domain


uniprot_information_type: SwissProt: Q6DN90
uniprot_information:
Belongs to the BRAG family &  Contains 1 IQ domain &  Contains 1 PH domain &  Contains 1 SEC7 domain


uniprot_information_type:
SwissProt: Q9C0E4 # PDZ 5 mediates the C-terminal binding of GRIA2 and GRIA3. PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1. PDZ 7 mediates interaction with CSPG4 (By similarity)# Belongs to the GRIP2 family &  Contains 7 PDZ (DHR) domains

uniprot_information:
SwissProt: Q9C0E4 # PDZ 5 mediates the C-terminal binding of GRIA2 and GRIA3. PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1. PDZ 7 mediates interaction with CSPG4 (By similarity)# Belongs to the GRIP2 family &  Contains 7 PDZ (DHR) domains


uniprot_information_type:
SwissProt: Q9Y215 # The proline-rich attachment domain (PRAD) binds the AChE catalytic subunits# Belongs to the COLQ family &  Contains 2 collagen-like domains

uniprot_information:
SwissProt: Q9Y215 # The proline-rich attachment domain (PRAD) binds the AChE catalytic subunits# Belongs to the COLQ family &  Contains 2 collagen-like domains


uniprot_information_type:
SwissProt: Q92904 # The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2# Belongs to the RRM DAZ family &  Contains 1 DAZ-like domain &  Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q92904 # The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2# Belongs to the RRM DAZ family &  Contains 1 DAZ-like domain &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: P10828 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P10828 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: Q96IV0 # The PUB domain mediates the interaction with VCP# Belongs to the transglutaminase-like superfamily. PNGase family &  Contains 1 PAW domain &  Contains 1 PUB (PUG) domain

uniprot_information:
SwissProt: Q96IV0 # The PUB domain mediates the interaction with VCP# Belongs to the transglutaminase-like superfamily. PNGase family &  Contains 1 PAW domain &  Contains 1 PUB (PUG) domain


uniprot_information_type:
SwissProt: Q9Y6M7 # The PDZ-binding motif mediates interaction with the CFTR, SLC9A3R1/EBP50 complex and probably with USH1C# Belongs to the anion exchanger (TC 2.A.31) family

uniprot_information:
SwissProt: Q9Y6M7 # The PDZ-binding motif mediates interaction with the CFTR, SLC9A3R1/EBP50 complex and probably with USH1C# Belongs to the anion exchanger (TC 2.A.31) family


uniprot_information_type:
SwissProt: O75122 # The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends# Belongs to the CLASP family &  Contains 5 HEAT repeats

uniprot_information:
SwissProt: O75122 # The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends# Belongs to the CLASP family &  Contains 5 HEAT repeats


uniprot_information_type:
SwissProt: Q14524 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.5/SCN5A subfamily &  Contains 1 IQ domain

uniprot_information:
SwissProt: Q14524 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.5/SCN5A subfamily &  Contains 1 IQ domain


uniprot_information_type:
SwissProt: Q9Y5Y9 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily &  Contains 1 IQ domain

uniprot_information:
SwissProt: Q9Y5Y9 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily &  Contains 1 IQ domain


uniprot_information_type:
SwissProt: Q9UI33 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily

uniprot_information:
SwissProt: Q9UI33 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily


uniprot_information_type:
SwissProt: Q96C45 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily &  Contains 5 HEAT repeats &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q96C45 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily &  Contains 5 HEAT repeats &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9NYG2 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q9NYG2 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: Q9BYW2 # The low charge region mediates the transcriptional activation activity# Belongs to the histone-lysine methyltransferase family. SET2 subfamily &  Contains 1 AWS domain &  Contains 1 post-SET domain &  Contains 1 SET domain &  Contains 1 WW domain

uniprot_information:
SwissProt: Q9BYW2 # The low charge region mediates the transcriptional activation activity# Belongs to the histone-lysine methyltransferase family. SET2 subfamily &  Contains 1 AWS domain &  Contains 1 post-SET domain &  Contains 1 SET domain &  Contains 1 WW domain


uniprot_information_type:
SwissProt: Q12770 # Cholesterol bound to SSC domain of SCAP or oxysterol bound to INSIG1/2 leads to masking of an ER export signal on SCAP possibly by moving the signal further away from the ER membrane (By similarity)# Belongs to the WD repeat SCAP family &  Contains 1 SSD (sterol-sensing) domain &  Contains 7 WD repeats

uniprot_information:
SwissProt: Q12770 # Cholesterol bound to SSC domain of SCAP or oxysterol bound to INSIG1/2 leads to masking of an ER export signal on SCAP possibly by moving the signal further away from the ER membrane (By similarity)# Belongs to the WD repeat SCAP family &  Contains 1 SSD (sterol-sensing) domain &  Contains 7 WD repeats


uniprot_information_type:
SwissProt: P30304 # The phosphodegron motif mediates interaction with specific F-box proteins when phosphorylated. Putative phosphorylation sites at Ser-79 and Ser-82 appear to be essential for this interaction# Belongs to the MPI phosphatase family &  Contains 1 rhodanese domain

uniprot_information:
SwissProt: P30304 # The phosphodegron motif mediates interaction with specific F-box proteins when phosphorylated. Putative phosphorylation sites at Ser-79 and Ser-82 appear to be essential for this interaction# Belongs to the MPI phosphatase family &  Contains 1 rhodanese domain


uniprot_information_type: SwissProt: Q02388
uniprot_information:
Contains 1 BPTI/Kunitz inhibitor domain &  Contains 9 fibronectin type-III domains &  Contains 2 VWFA domains


uniprot_information_type: SwissProt: Q9NYQ7
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 9 cadherin domains &  Contains 8 EGF-like domains &  Contains 1 GPS domain &  Contains 1 laminin EGF-like domain &  Contains 2 laminin G-like domains


uniprot_information_type: SwissProt: P13861
uniprot_information:
Belongs to the cAMP-dependent kinase regulatory chain family &  Contains 2 cyclic nucleotide-binding domains


uniprot_information_type:
SwissProt: P55268 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domains VI and IV are globular# Contains 13 laminin EGF-like domains &  Contains 1 laminin IV type B domain &  Contains 1 laminin N-terminal domain

uniprot_information:
SwissProt: P55268 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domains VI and IV are globular# Contains 13 laminin EGF-like domains &  Contains 1 laminin IV type B domain &  Contains 1 laminin N-terminal domain


uniprot_information_type:
SwissProt: P61586 # The basic-rich region is essential for yopT recognition and cleavage# Belongs to the small GTPase superfamily. Rho family

uniprot_information:
SwissProt: P61586 # The basic-rich region is essential for yopT recognition and cleavage# Belongs to the small GTPase superfamily. Rho family


uniprot_information_type:
SwissProt: Q8NCB2 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q8NCB2 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q04912
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family &  Contains 3 IPT/TIG domains &  Contains 1 protein kinase domain &  Contains 1 Sema domain


uniprot_information_type: SwissProt: Q9NS23
uniprot_information:
Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 Ras-associating domain &  Contains 1 SARAH domain


uniprot_information_type:
SwissProt: Q9NY47 # The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch (By similarity)# Belongs to the calcium channel subunit alpha-2/delta family &  Contains 1 cache domain &  Contains 1 VWFA domain

uniprot_information:
SwissProt: Q9NY47 # The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch (By similarity)# Belongs to the calcium channel subunit alpha-2/delta family &  Contains 1 cache domain &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q9Y4B6 # The DWD boxes are required for interaction with DDB1# Belongs to the VPRBP/DCAF1 family &  Contains 1 LisH domain &  Contains 5 WD repeats

uniprot_information:
SwissProt: Q9Y4B6 # The DWD boxes are required for interaction with DDB1# Belongs to the VPRBP/DCAF1 family &  Contains 1 LisH domain &  Contains 5 WD repeats


uniprot_information_type:
SwissProt: O43818 # The WD domains are required for nucleolar localization and U3 small nucleolar RNAs binding# Belongs to the WD repeat RRP9 family &  Contains 7 WD repeats

uniprot_information:
SwissProt: O43818 # The WD domains are required for nucleolar localization and U3 small nucleolar RNAs binding# Belongs to the WD repeat RRP9 family &  Contains 7 WD repeats


uniprot_information_type: SwissProt: Q9NS98
uniprot_information:
Belongs to the semaphorin family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Sema domain


uniprot_information_type:
SwissProt: Q9ULU8 # The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It however does not mediate binding to DCVs (By similarity)# Contains 1 C2 domain &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q9ULU8 # The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It however does not mediate binding to DCVs (By similarity)# Contains 1 C2 domain &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q9P2N4 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix (By similarity) &  The ancillary domains, including the TSRs domain, are required for specific extracellular localization and for its versicanase and aggrecanase activities &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 GON domain &  Contains 1 peptidase M12B domain &  Contains 15 TSP type-1 domains

uniprot_information:
SwissProt: Q9P2N4 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix (By similarity) &  The ancillary domains, including the TSRs domain, are required for specific extracellular localization and for its versicanase and aggrecanase activities &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 GON domain &  Contains 1 peptidase M12B domain &  Contains 15 TSP type-1 domains


uniprot_information_type:
SwissProt: Q96JA1 # The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted# Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 17 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q96JA1 # The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted# Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 17 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: P82094 # The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]#

uniprot_information:
SwissProt: P82094 # The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]#


uniprot_information_type:
SwissProt: Q9UPQ7 # The RING-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 2 PDZ (DHR) domains &  Contains 1 RING-type zinc finger &  Contains 1 TRAF-type zinc finger

uniprot_information:
SwissProt: Q9UPQ7 # The RING-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 2 PDZ (DHR) domains &  Contains 1 RING-type zinc finger &  Contains 1 TRAF-type zinc finger


uniprot_information_type: SwissProt: Q9Y6N7
uniprot_information:
Belongs to the immunoglobulin superfamily. ROBO family &  Contains 3 fibronectin type-III domains &  Contains 5 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: P28069
uniprot_information:
Belongs to the POU transcription factor family. Class-1 subfamily &  Contains 1 homeobox DNA-binding domain &  Contains 1 POU-specific domain


uniprot_information_type: SwissProt: P07225
uniprot_information:
Contains 4 EGF-like domains &  Contains 1 Gla (gamma-carboxy-glutamate) domain &  Contains 2 laminin G-like domains


uniprot_information_type:
SwissProt: Q13191 # The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain &  The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme &  The UBA domain interacts with poly-ubiquitinated proteins# Contains 1 CBL N-terminal domain &  Contains 2 EF-hand-like domains &  Contains 1 RING-type zinc finger &  Contains 1 SH2 domain &  Contains 1 UBA domain

uniprot_information:
SwissProt: Q13191 # The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain &  The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme &  The UBA domain interacts with poly-ubiquitinated proteins# Contains 1 CBL N-terminal domain &  Contains 2 EF-hand-like domains &  Contains 1 RING-type zinc finger &  Contains 1 SH2 domain &  Contains 1 UBA domain


uniprot_information_type:
SwissProt: Q9NWB7 # The pseudo DED region (pDED) meadiates the interaction with HIP1# Belongs to the IFT57 family

uniprot_information:
SwissProt: Q9NWB7 # The pseudo DED region (pDED) meadiates the interaction with HIP1# Belongs to the IFT57 family


uniprot_information_type:
SwissProt: Q9Y2K3 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils (By similarity)# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: Q9Y2K3 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils (By similarity)# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type: SwissProt: Q13449
uniprot_information:
Belongs to the immunoglobulin superfamily. IgLON family &  Contains 3 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: P49841
uniprot_information:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q12841
uniprot_information:
Contains 2 EF-hand domains &  Contains 1 follistatin-like domain &  Contains 1 Kazal-like domain &  Contains 1 VWFC domain


uniprot_information_type:
SwissProt: P52294 # Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import &  The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity) &  The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)# Belongs to the importin alpha family &  Contains 10 ARM repeats &  Contains 1 IBB domain

uniprot_information:
SwissProt: P52294 # Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import &  The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity) &  The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)# Belongs to the importin alpha family &  Contains 10 ARM repeats &  Contains 1 IBB domain


uniprot_information_type: SwissProt: Q15746
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 fibronectin type-III domain &  Contains 9 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9HAT0 # The RIIa domain mediates interaction with AKAP3 (By similarity)# Belongs to the ropporin family &  Contains 1 RIIa domain

uniprot_information:
SwissProt: Q9HAT0 # The RIIa domain mediates interaction with AKAP3 (By similarity)# Belongs to the ropporin family &  Contains 1 RIIa domain


uniprot_information_type: SwissProt: O75891
uniprot_information:
In the N-terminal section; belongs to the GART family &  In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily &  Contains 1 acyl carrier domain


uniprot_information_type:
SwissProt: Q9Y265 # Binding to MYC is dependent on a Myc domain essential for oncogenic activity# Belongs to the ruvB family

uniprot_information:
SwissProt: Q9Y265 # Binding to MYC is dependent on a Myc domain essential for oncogenic activity# Belongs to the ruvB family


uniprot_information_type: SwissProt: Q99570
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 3 HEAT repeats &  Contains 1 protein kinase domain &  Contains 7 WD repeats


uniprot_information_type: SwissProt: P34925
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family &  Contains 1 protein kinase domain &  Contains 1 WIF domain


uniprot_information_type:
SwissProt: Q9UNA3 # The conserved DXD motif is involved in enzyme activity (By similarity)# Belongs to the glycosyltransferase 32 family

uniprot_information:
SwissProt: Q9UNA3 # The conserved DXD motif is involved in enzyme activity (By similarity)# Belongs to the glycosyltransferase 32 family


uniprot_information_type:
SwissProt: P09455 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior (By similarity)# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

uniprot_information:
SwissProt: P09455 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior (By similarity)# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


uniprot_information_type: SwissProt: Q13535
uniprot_information:
Belongs to the PI3/PI4-kinase family. ATM subfamily &  Contains 1 FAT domain &  Contains 1 FATC domain &  Contains 2 HEAT repeats &  Contains 1 PI3K/PI4K domain


uniprot_information_type: SwissProt: Q14527
uniprot_information:
Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: P00450
uniprot_information:
Belongs to the multicopper oxidase family &  Contains 3 F5/8 type A domains &  Contains 6 plastocyanin-like domains


uniprot_information_type:
SwissProt: Q9GZV5 # The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes (By similarity) &  Binds to transcription factors via its WW domain# Contains 1 WW domain

uniprot_information:
SwissProt: Q9GZV5 # The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes (By similarity) &  Binds to transcription factors via its WW domain# Contains 1 WW domain


uniprot_information_type:
SwissProt: O43255 # The RING-type zinc finger domain is essential for ubiquitin ligase activity &  The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family (By similarity)# Belongs to the SINA (Seven in absentia) family &  Contains 1 RING-type zinc finger &  Contains 1 SIAH-type zinc finger

uniprot_information:
SwissProt: O43255 # The RING-type zinc finger domain is essential for ubiquitin ligase activity &  The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family (By similarity)# Belongs to the SINA (Seven in absentia) family &  Contains 1 RING-type zinc finger &  Contains 1 SIAH-type zinc finger


uniprot_information_type:
SwissProt: Q9UK58 # Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions# Belongs to the cyclin family. Cyclin L subfamily

uniprot_information:
SwissProt: Q9UK58 # Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions# Belongs to the cyclin family. Cyclin L subfamily


uniprot_information_type:
SwissProt: O00629 # Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import &  The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity) &  The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)# Belongs to the importin alpha family &  Contains 10 ARM repeats &  Contains 1 IBB domain

uniprot_information:
SwissProt: O00629 # Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import &  The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity) &  The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)# Belongs to the importin alpha family &  Contains 10 ARM repeats &  Contains 1 IBB domain


uniprot_information_type:
SwissProt: Q03112 # Both zinc finger regions are required for the transcriptional activation of PBX1# Contains 10 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q03112 # Both zinc finger regions are required for the transcriptional activation of PBX1# Contains 10 C2H2-type zinc fingers


uniprot_information_type: SwissProt: Q13393
uniprot_information:
Belongs to the phospholipase D family &  Contains 1 PH domain &  Contains 2 PLD phosphodiesterase domains &  Contains 1 PX (phox homology) domain


uniprot_information_type:
SwissProt: Q9BZK7 # The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes (By similarity)# Belongs to the WD repeat EBI family &  Contains 1 F-box-like domain &  Contains 1 LisH domain &  Contains 8 WD repeats

uniprot_information:
SwissProt: Q9BZK7 # The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes (By similarity)# Belongs to the WD repeat EBI family &  Contains 1 F-box-like domain &  Contains 1 LisH domain &  Contains 8 WD repeats


uniprot_information_type:
SwissProt: Q9NPA1 # Isoform 4 cytoplasmic N-terminus domain participates in the partial inactivation of KCNMA1, possibly by binding to a receptor site &  The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be rapidly diminished upon cellular repolarization# Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily

uniprot_information:
SwissProt: Q9NPA1 # Isoform 4 cytoplasmic N-terminus domain participates in the partial inactivation of KCNMA1, possibly by binding to a receptor site &  The extracellular domain forms gates to block ion permeation, providing a mechanism by which current can be rapidly diminished upon cellular repolarization# Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily


uniprot_information_type: SwissProt: Q96RQ3
uniprot_information:
Contains 1 ATP-grasp domain &  Contains 1 biotin carboxylation domain &  Contains 1 biotinyl-binding domain


uniprot_information_type: SwissProt: Q86YR7
uniprot_information:
Belongs to the MCF2 family &  Contains 1 CRAL-TRIO domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 spectrin repeat


uniprot_information_type: SwissProt: O15440
uniprot_information:
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily &  Contains 2 ABC transmembrane type-1 domains &  Contains 2 ABC transporter domains


uniprot_information_type:
SwissProt: P40225 # Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal# Belongs to the EPO/TPO family

uniprot_information:
SwissProt: P40225 # Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal# Belongs to the EPO/TPO family


uniprot_information_type: SwissProt: Q08426
uniprot_information:
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family &  In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family


uniprot_information_type:
SwissProt: Q9Y6M1 # The third and fourth KH domains are important for binding to the untranslated region (UTR) of target mRNA# Belongs to the RRM IMP/VICKZ family &  Contains 4 KH domains &  Contains 2 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: Q9Y6M1 # The third and fourth KH domains are important for binding to the untranslated region (UTR) of target mRNA# Belongs to the RRM IMP/VICKZ family &  Contains 4 KH domains &  Contains 2 RRM (RNA recognition motif) domains


uniprot_information_type: SwissProt: P49619
uniprot_information:
Belongs to the eukaryotic diacylglycerol kinase family &  Contains 1 DAGKc domain &  Contains 2 EF-hand domains &  Contains 2 phorbol-ester/DAG-type zinc fingers


uniprot_information_type:
SwissProt: P41182 # The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2# Contains 1 BTB (POZ) domain &  Contains 6 C2H2-type zinc fingers

uniprot_information:
SwissProt: P41182 # The BTB domain mediates homodimerization. Its dimer interface mediates peptide binding such as to corepressors BCOR and NCOR2# Contains 1 BTB (POZ) domain &  Contains 6 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q9H089 # In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern# Belongs to the MMR1/HSR1 GTP-binding protein family. LSG1 subfamily

uniprot_information:
SwissProt: Q9H089 # In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern# Belongs to the MMR1/HSR1 GTP-binding protein family. LSG1 subfamily


uniprot_information_type: SwissProt: Q15057
uniprot_information:
Contains 3 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 BAR domain &  Contains 1 PH domain


uniprot_information_type: SwissProt: Q99102
uniprot_information:
Contains 1 AMOP domain &  Contains 2 EGF-like domains &  Contains 1 NIDO domain &  Contains 1 VWFD domain


uniprot_information_type: SwissProt: Q07912
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family &  Contains 1 CRIB domain &  Contains 1 protein kinase domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q12959 # The alternatively spliced domain I3 corresponding to amino acids (636-669) of isoform 4 is an EPB41 binding site mediating association to membranes in polarized and non-polarized cells &  The PDZ domains may also mediate association to membranes by binding to EPB41 and GPR124 together with the L27 domain that binds CASK and DLG2 &  The L27 domain may regulate DLG1 self-association. The N-terminal alternatively spliced region is capable of binding several SH3 domains and also moderates the level of protein oligomerization# Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 1 L27 domain &  Contains 3 PDZ (DHR) domains &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q12959 # The alternatively spliced domain I3 corresponding to amino acids (636-669) of isoform 4 is an EPB41 binding site mediating association to membranes in polarized and non-polarized cells &  The PDZ domains may also mediate association to membranes by binding to EPB41 and GPR124 together with the L27 domain that binds CASK and DLG2 &  The L27 domain may regulate DLG1 self-association. The N-terminal alternatively spliced region is capable of binding several SH3 domains and also moderates the level of protein oligomerization# Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 1 L27 domain &  Contains 3 PDZ (DHR) domains &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: O00533 # The FIG[AQ]Y motif seems to be an ankyrin recruitment region &  The DGEA motif seems to be a recognition site for integrin# Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family &  Contains 4 fibronectin type-III domains &  Contains 6 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: O00533 # The FIG[AQ]Y motif seems to be an ankyrin recruitment region &  The DGEA motif seems to be a recognition site for integrin# Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family &  Contains 4 fibronectin type-III domains &  Contains 6 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q53H47 # The mariner transposase Hsmar1 region mediates DNA-binding. It has no transposase activity because the active site contains an Asn in position 610 instead of a Asp residue# In the N-terminal section; belongs to the histone-lysine methyltransferase family &  In the C-terminal section; belongs to the mariner transposase family &  Contains 1 post-SET domain &  Contains 1 pre-SET domain &  Contains 1 SET domain

uniprot_information:
SwissProt: Q53H47 # The mariner transposase Hsmar1 region mediates DNA-binding. It has no transposase activity because the active site contains an Asn in position 610 instead of a Asp residue# In the N-terminal section; belongs to the histone-lysine methyltransferase family &  In the C-terminal section; belongs to the mariner transposase family &  Contains 1 post-SET domain &  Contains 1 pre-SET domain &  Contains 1 SET domain


uniprot_information_type:
SwissProt: Q14643 # The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region# Belongs to the InsP3 receptor family &  Contains 5 MIR domains

uniprot_information:
SwissProt: Q14643 # The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region# Belongs to the InsP3 receptor family &  Contains 5 MIR domains


uniprot_information_type:
SwissProt: Q9NZU5 # The LIM zinc-binding domains and the Cys-rich region mediate interaction with GATA6 (By similarity)# Contains 2 LIM zinc-binding domains &  Contains 1 PET domain

uniprot_information:
SwissProt: Q9NZU5 # The LIM zinc-binding domains and the Cys-rich region mediate interaction with GATA6 (By similarity)# Contains 2 LIM zinc-binding domains &  Contains 1 PET domain


uniprot_information_type: SwissProt: P55201
uniprot_information:
Contains 1 bromo domain &  Contains 1 C2H2-type zinc finger &  Contains 1 PHD-type zinc finger &  Contains 1 PWWP domain


uniprot_information_type:
SwissProt: P30531 # The PDZ domain-binding motif is involved in the interaction with MPP5# Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily

uniprot_information:
SwissProt: P30531 # The PDZ domain-binding motif is involved in the interaction with MPP5# Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily


uniprot_information_type:
SwissProt: O95352 # The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12 (By similarity)# Belongs to the ATG7 family

uniprot_information:
SwissProt: O95352 # The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12 (By similarity)# Belongs to the ATG7 family


uniprot_information_type: SwissProt: P98095
uniprot_information:
Belongs to the fibulin family &  Contains 3 anaphylatoxin-like domains &  Contains 11 EGF-like domains


uniprot_information_type: SwissProt: P49116
uniprot_information:
Belongs to the nuclear hormone receptor family. NR2 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: Q92831 # The bromodomain mediates binding to HIV-1 Tat# Belongs to the GCN5 family &  Contains 1 bromo domain &  Contains 1 N-acetyltransferase domain

uniprot_information:
SwissProt: Q92831 # The bromodomain mediates binding to HIV-1 Tat# Belongs to the GCN5 family &  Contains 1 bromo domain &  Contains 1 N-acetyltransferase domain


uniprot_information_type:
SwissProt: P10826 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P10826 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type: SwissProt: O15195
uniprot_information:
Belongs to the villin/gelsolin family &  Contains 6 gelsolin-like repeats &  Contains 1 HP (headpiece) domain


uniprot_information_type:
SwissProt: Q99836 # The intermediate domain (ID) is required for the phosphorylation and activation of IRAK (By similarity)# Contains 1 death domain &  Contains 1 TIR domain

uniprot_information:
SwissProt: Q99836 # The intermediate domain (ID) is required for the phosphorylation and activation of IRAK (By similarity)# Contains 1 death domain &  Contains 1 TIR domain


uniprot_information_type:
SwissProt: Q8TAF3 # N-terminal WD region interacts with TIP and C-terminal region mediates lysosomal localization. The WD repeats are required for the interaction with deubiquitinating enzymes USP1, USP12 and USP46# Belongs to the WD repeat WDR48 family &  Contains 8 WD repeats

uniprot_information:
SwissProt: Q8TAF3 # N-terminal WD region interacts with TIP and C-terminal region mediates lysosomal localization. The WD repeats are required for the interaction with deubiquitinating enzymes USP1, USP12 and USP46# Belongs to the WD repeat WDR48 family &  Contains 8 WD repeats


uniprot_information_type:
SwissProt: Q9UPV9 # The C-terminal region is required for the early endosomal and mitochondrial localization# Contains 1 HAP1 N-terminal domain

uniprot_information:
SwissProt: Q9UPV9 # The C-terminal region is required for the early endosomal and mitochondrial localization# Contains 1 HAP1 N-terminal domain


uniprot_information_type: SwissProt: Q9NRH2
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 protein kinase domain &  Contains 1 UBA domain


uniprot_information_type:
SwissProt: Q8WTS1 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily

uniprot_information:
SwissProt: Q8WTS1 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily


uniprot_information_type: SwissProt: Q9P0L1
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 13 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: O14709
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 22 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: Q7L2E3
uniprot_information:
Belongs to the DEAD box helicase family. DEAH subfamily &  Contains 1 DRBM (double-stranded RNA-binding) domain &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q86UQ0 # The KRAB domain mediates interaction with TRIM28# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 4 C2H2-type zinc fingers &  Contains 1 KRAB domain

uniprot_information:
SwissProt: Q86UQ0 # The KRAB domain mediates interaction with TRIM28# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 4 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: O95376 # RING-type 1 and RING-type 2 are required for the inhibitory function in myelopoiesis# Belongs to the RBR family. Ariadne subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers

uniprot_information:
SwissProt: O95376 # RING-type 1 and RING-type 2 are required for the inhibitory function in myelopoiesis# Belongs to the RBR family. Ariadne subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers


uniprot_information_type: SwissProt: P52756
uniprot_information:
Belongs to the RBM5/RBM10 family &  Contains 1 C2H2-type zinc finger &  Contains 1 G-patch domain &  Contains 1 RanBP2-type zinc finger &  Contains 2 RRM (RNA recognition motif) domains


uniprot_information_type:
SwissProt: Q8IZD9 # The DHR-2 domain may mediate some GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q8IZD9 # The DHR-2 domain may mediate some GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P55145 # The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response# Belongs to the ARMET family

uniprot_information:
SwissProt: P55145 # The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response# Belongs to the ARMET family


uniprot_information_type:
SwissProt: Q9Y4B4 # Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors (By similarity)# Belongs to the SNF2/RAD54 helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain

uniprot_information:
SwissProt: Q9Y4B4 # Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors (By similarity)# Belongs to the SNF2/RAD54 helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q9Y6F1 # According to PubMed:10329013 the N-terminal domain (54 amino acids) of isoform 2 is responsible for its centrosomal localization. The C-terminal region contains the catalytic domain# Contains 1 PARP alpha-helical domain &  Contains 1 PARP catalytic domain

uniprot_information:
SwissProt: Q9Y6F1 # According to PubMed:10329013 the N-terminal domain (54 amino acids) of isoform 2 is responsible for its centrosomal localization. The C-terminal region contains the catalytic domain# Contains 1 PARP alpha-helical domain &  Contains 1 PARP catalytic domain


uniprot_information_type:
SwissProt: Q9Y2I1 # Both the presence of the PX domain and the coiled coil region are necessary for its endosomal targeting# Contains 6 LRR (leucine-rich) repeats &  Contains 1 PX (phox homology) domain

uniprot_information:
SwissProt: Q9Y2I1 # Both the presence of the PX domain and the coiled coil region are necessary for its endosomal targeting# Contains 6 LRR (leucine-rich) repeats &  Contains 1 PX (phox homology) domain


uniprot_information_type: SwissProt: Q9NY15
uniprot_information:
Contains 16 EGF-like domains &  Contains 7 FAS1 domains &  Contains 2 laminin EGF-like domains &  Contains 1 Link domain


uniprot_information_type:
SwissProt: Q9BVP2 # The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis (By similarity) &  In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern# Belongs to the MMR1/HSR1 GTP-binding protein family

uniprot_information:
SwissProt: Q9BVP2 # The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis (By similarity) &  In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern# Belongs to the MMR1/HSR1 GTP-binding protein family


uniprot_information_type:
SwissProt: Q05655 # The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor &  The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a sequence-specific manner# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q05655 # The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor &  The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a sequence-specific manner# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q01668 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily

uniprot_information:
SwissProt: Q01668 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1D subfamily


uniprot_information_type:
SwissProt: Q8IZS8 # The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch (By similarity)# Belongs to the calcium channel subunit alpha-2/delta family &  Contains 1 cache domain &  Contains 1 VWFA domain

uniprot_information:
SwissProt: Q8IZS8 # The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch (By similarity)# Belongs to the calcium channel subunit alpha-2/delta family &  Contains 1 cache domain &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q9UKG1 # Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect# Contains 1 PH domain &  Contains 1 PID domain

uniprot_information:
SwissProt: Q9UKG1 # Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect# Contains 1 PH domain &  Contains 1 PID domain


uniprot_information_type:
SwissProt: O75369 # Comprised of a NH2-terminal actin-binding domain, 24 internally homologous repeats and two hinge regions. Repeat 24 and the second hinge domain are important for dimer formation. The first hinge region prevents binding to ITGA and ITGB subunits# Belongs to the filamin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 24 filamin repeats

uniprot_information:
SwissProt: O75369 # Comprised of a NH2-terminal actin-binding domain, 24 internally homologous repeats and two hinge regions. Repeat 24 and the second hinge domain are important for dimer formation. The first hinge region prevents binding to ITGA and ITGB subunits# Belongs to the filamin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 24 filamin repeats


uniprot_information_type: SwissProt: P23470
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily &  Contains 1 alpha-carbonic anhydrase domain &  Contains 1 fibronectin type-III domain &  Contains 2 tyrosine-protein phosphatase domains


uniprot_information_type:
SwissProt: Q9UQN3 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity)# Belongs to the SNF7 family

uniprot_information:
SwissProt: Q9UQN3 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity)# Belongs to the SNF7 family


uniprot_information_type: SwissProt: Q68DQ2
uniprot_information:
Belongs to the beta/gamma-crystallin family &  Contains 9 beta/gamma crystallin 'Greek key' domains &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: Q13740 # The CD6 binding site is located in the N-terminal Ig-like domain# Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 2 Ig-like V-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: Q13740 # The CD6 binding site is located in the N-terminal Ig-like domain# Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 2 Ig-like V-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q9UM44
uniprot_information:
Contains 1 Ig-like C1-type (immunoglobulin-like) domain &  Contains 2 Ig-like V-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q9NQS3
uniprot_information:
Belongs to the nectin family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P40200
uniprot_information:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 2 Ig-like V-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q9Y2K9
uniprot_information:
Belongs to the WD repeat L(2)GL family &  Contains 1 v-SNARE coiled-coil homology domain &  Contains 14 WD repeats


uniprot_information_type:
SwissProt: O60229 # The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 CRAL-TRIO domain &  Contains 2 DH (DBL-homology) domains &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 2 PH domains &  Contains 1 protein kinase domain &  Contains 2 SH3 domains &  Contains 5 spectrin repeats

uniprot_information:
SwissProt: O60229 # The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 CRAL-TRIO domain &  Contains 2 DH (DBL-homology) domains &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 2 PH domains &  Contains 1 protein kinase domain &  Contains 2 SH3 domains &  Contains 5 spectrin repeats


uniprot_information_type: SwissProt: P11172
uniprot_information:
In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family &  In the C-terminal section; belongs to the OMP decarboxylase family


uniprot_information_type:
SwissProt: Q9H4D0 # Binds synaptic Ca(2+) with its cytoplasmic domain (By similarity)# Contains 2 cadherin domains

uniprot_information:
SwissProt: Q9H4D0 # Binds synaptic Ca(2+) with its cytoplasmic domain (By similarity)# Contains 2 cadherin domains


uniprot_information_type: SwissProt: Q15283
uniprot_information:
Contains 1 Btk-type zinc finger &  Contains 2 C2 domains &  Contains 1 PH domain &  Contains 1 Ras-GAP domain


uniprot_information_type:
SwissProt: Q9UBF6 # The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion# Belongs to the RING-box family &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q9UBF6 # The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion# Belongs to the RING-box family &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q14651
uniprot_information:
Contains 2 actin-binding domains &  Contains 4 CH (calponin-homology) domains &  Contains 2 EF-hand domains


uniprot_information_type: SwissProt: P48995
uniprot_information:
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily &  Contains 3 ANK repeats


uniprot_information_type: SwissProt: O15042
uniprot_information:
Belongs to the splicing factor SR family &  Contains 1 CID domain &  Contains 1 RRM (RNA recognition motif) domain &  Contains 1 SURP motif repeat


uniprot_information_type:
SwissProt: O43567 # The RING-type zinc finger domain is required for E3 ligase activity# Contains 1 PA (protease associated) domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: O43567 # The RING-type zinc finger domain is required for E3 ligase activity# Contains 1 PA (protease associated) domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: P61225 # The effector domain mediates the interaction with RUNDC3A (By similarity)# Belongs to the small GTPase superfamily. Ras family

uniprot_information:
SwissProt: P61225 # The effector domain mediates the interaction with RUNDC3A (By similarity)# Belongs to the small GTPase superfamily. Ras family


uniprot_information_type:
SwissProt: Q14722 # Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (Probable)# Belongs to the shaker potassium channel beta subunit family

uniprot_information:
SwissProt: Q14722 # Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (Probable)# Belongs to the shaker potassium channel beta subunit family


uniprot_information_type:
SwissProt: Q9NTJ3 # The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC2, forming a V-shaped heterodimer (By similarity)# Belongs to the SMC family. SMC4 subfamily

uniprot_information:
SwissProt: Q9NTJ3 # The hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC2, forming a V-shaped heterodimer (By similarity)# Belongs to the SMC family. SMC4 subfamily


uniprot_information_type: SwissProt: Q9NPC7
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 8 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: P41743 # The OPR domain mediates interaction with SQSTM1 (By similarity) &  The C1 domain does not bind diacylglycerol (DAG)# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 OPR domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P41743 # The OPR domain mediates interaction with SQSTM1 (By similarity) &  The C1 domain does not bind diacylglycerol (DAG)# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 OPR domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9Y691 # The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus# Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily

uniprot_information:
SwissProt: Q9Y691 # The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus# Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily


uniprot_information_type: SwissProt: Q9NUQ8
uniprot_information:
Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily &  Contains 2 ABC transporter domains


uniprot_information_type: SwissProt: O60344
uniprot_information:
In the N-terminal section; belongs to the methyltransferase superfamily &  In the C-terminal section; belongs to the peptidase M13 family


uniprot_information_type: SwissProt: Q04637
uniprot_information:
Belongs to the eIF4G family &  Contains 1 MI domain &  Contains 1 MIF4G domain &  Contains 1 W2 domain


uniprot_information_type:
SwissProt: Q9HC62 # The N-terminus is necessary and sufficient for nuclear envelope targeting# Belongs to the peptidase C48 family

uniprot_information:
SwissProt: Q9HC62 # The N-terminus is necessary and sufficient for nuclear envelope targeting# Belongs to the peptidase C48 family


uniprot_information_type:
SwissProt: P04196 # In addition to having a high His and Pro content, this protein has many internal repeats. 12 tandem repetitions of a 5-residue sequence (GHHPH, consensus) form a histidine-rich region# Contains 2 cystatin domains

uniprot_information:
SwissProt: P04196 # In addition to having a high His and Pro content, this protein has many internal repeats. 12 tandem repetitions of a 5-residue sequence (GHHPH, consensus) form a histidine-rich region# Contains 2 cystatin domains


uniprot_information_type: SwissProt: Q14240
uniprot_information:
Belongs to the DEAD box helicase family. eIF4A subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q15848 # The C1q domain is commonly called the globular domain# Contains 1 C1q domain &  Contains 1 collagen-like domain

uniprot_information:
SwissProt: Q15848 # The C1q domain is commonly called the globular domain# Contains 1 C1q domain &  Contains 1 collagen-like domain


uniprot_information_type:
SwissProt: Q9H3D4 # The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms# Belongs to the p53 family &  Contains 1 SAM (sterile alpha motif) domain

uniprot_information:
SwissProt: Q9H3D4 # The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms# Belongs to the p53 family &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: Q14469 # Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) &  The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity) &  The bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW motif, is required for transcriptional repressor activity (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain

uniprot_information:
SwissProt: Q14469 # Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) &  The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity) &  The bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW motif, is required for transcriptional repressor activity (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain


uniprot_information_type: SwissProt: Q13177
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 CRIB domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O14976
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 1 C2 tensin-type domain &  Contains 1 J domain &  Contains 1 phosphatase tensin-type domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P52824 # The L-X-X-L-L repeats are implicated in binding to the nuclear receptor NR5A1# Belongs to the eukaryotic diacylglycerol kinase family &  Contains 1 DAGKc domain &  Contains 3 phorbol-ester/DAG-type zinc fingers &  Contains 1 Ras-associating domain

uniprot_information:
SwissProt: P52824 # The L-X-X-L-L repeats are implicated in binding to the nuclear receptor NR5A1# Belongs to the eukaryotic diacylglycerol kinase family &  Contains 1 DAGKc domain &  Contains 3 phorbol-ester/DAG-type zinc fingers &  Contains 1 Ras-associating domain


uniprot_information_type:
SwissProt: Q14493 # Amino acids 31-34, 96-99 and 241-244 are necessary for interaction with the Importin alpha/Importin beta receptor. The first 18 amino acids, amino acids 69-76 and 179-182 are necessary for interaction with TNPO3. Amino acids 31-34, 96-99 and 241-244 are necessary for nuclear localization# Belongs to the SLBP family

uniprot_information:
SwissProt: Q14493 # Amino acids 31-34, 96-99 and 241-244 are necessary for interaction with the Importin alpha/Importin beta receptor. The first 18 amino acids, amino acids 69-76 and 179-182 are necessary for interaction with TNPO3. Amino acids 31-34, 96-99 and 241-244 are necessary for nuclear localization# Belongs to the SLBP family


uniprot_information_type:
SwissProt: Q9H3P2 # The HDAg-like domain is essential for transcriptional repression, and mediates the interaction with the RNA polymerase II complex# Belongs to the NELF-A family &  Contains 1 HDAg-like domain

uniprot_information:
SwissProt: Q9H3P2 # The HDAg-like domain is essential for transcriptional repression, and mediates the interaction with the RNA polymerase II complex# Belongs to the NELF-A family &  Contains 1 HDAg-like domain


uniprot_information_type:
SwissProt: Q9UKA1 # The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded# Contains 1 F-box domain &  Contains 4 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q9UKA1 # The hemerythrin-like region acts as an oxygen and iron sensor by binding oxygen through a diiron metal-center. In absence of oxygen and iron, the protein is ubiquitinated and degraded# Contains 1 F-box domain &  Contains 4 LRR (leucine-rich) repeats


uniprot_information_type: SwissProt: O43143
uniprot_information:
Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: Q8WZ64
uniprot_information:
Contains 1 Arf-GAP domain &  Contains 5 PH domains &  Contains 1 Ras-associating domain &  Contains 1 Rho-GAP domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type: SwissProt: Q15399
uniprot_information:
Belongs to the Toll-like receptor family &  Contains 8 LRR (leucine-rich) repeats &  Contains 1 TIR domain


uniprot_information_type: SwissProt: Q9Y2C9
uniprot_information:
Belongs to the Toll-like receptor family &  Contains 13 LRR (leucine-rich) repeats &  Contains 1 TIR domain


uniprot_information_type: SwissProt: P47869
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily


uniprot_information_type: SwissProt: P48169
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA4 sub-subfamily


uniprot_information_type: SwissProt: P29973
uniprot_information:
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA1 subfamily &  Contains 1 cyclic nucleotide-binding domain


uniprot_information_type: SwissProt: P42680
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily &  Contains 1 Btk-type zinc finger &  Contains 1 PH domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: P35968
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily &  Contains 7 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q06203
uniprot_information:
In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family &  Contains 1 glutamine amidotransferase type-2 domain


uniprot_information_type: SwissProt: Q16270
uniprot_information:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 IGFBP N-terminal domain &  Contains 1 Kazal-like domain


uniprot_information_type:
SwissProt: Q03188 # The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization# Belongs to the CENPC family

uniprot_information:
SwissProt: Q03188 # The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization# Belongs to the CENPC family


uniprot_information_type:
SwissProt: O15072 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 4 TSP type-1 domains

uniprot_information:
SwissProt: O15072 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 4 TSP type-1 domains


uniprot_information_type: SwissProt: Q96PM5
uniprot_information:
Contains 1 CHY-type zinc finger &  Contains 1 CTCHY-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q92772 # The [NKR]KIAxRE motif seems to be a cyclin-binding region# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q92772 # The [NKR]KIAxRE motif seems to be a cyclin-binding region# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q13237
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 2 cyclic nucleotide-binding domains &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q86SK9 # The histidine box domains may contain the active site and/or be involved in metal ion binding (By similarity)# Belongs to the fatty acid desaturase family

uniprot_information:
SwissProt: Q86SK9 # The histidine box domains may contain the active site and/or be involved in metal ion binding (By similarity)# Belongs to the fatty acid desaturase family


uniprot_information_type:
SwissProt: P78426 # The C-terminal domain contributes to sequence-specific DNA-binding (By similarity)# Contains 1 homeobox DNA-binding domain

uniprot_information:
SwissProt: P78426 # The C-terminal domain contributes to sequence-specific DNA-binding (By similarity)# Contains 1 homeobox DNA-binding domain


uniprot_information_type: SwissProt: Q8IZQ1
uniprot_information:
Contains 1 BEACH domain &  Contains 1 FYVE-type zinc finger &  Contains 2 LRR (leucine-rich) repeats &  Contains 5 WD repeats


uniprot_information_type:
SwissProt: P53779 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P53779 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q14515
uniprot_information:
Belongs to the SPARC family &  Contains 1 EF-hand domain &  Contains 1 follistatin-like domain &  Contains 1 Kazal-like domain


uniprot_information_type: SwissProt: Q9UNQ0
uniprot_information:
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily &  Contains 1 ABC transmembrane type-2 domain &  Contains 1 ABC transporter domain


uniprot_information_type:
SwissProt: P37840 # The NAC domain is involved in the fibril formation. The middle region forms the core of the filaments. The C-terminus may regulate aggregation and determine the diameter of the filaments# Belongs to the synuclein family

uniprot_information:
SwissProt: P37840 # The NAC domain is involved in the fibril formation. The middle region forms the core of the filaments. The C-terminus may regulate aggregation and determine the diameter of the filaments# Belongs to the synuclein family


uniprot_information_type: SwissProt: O60760
uniprot_information:
Belongs to the GST superfamily. Sigma family &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain


uniprot_information_type: SwissProt: O95185
uniprot_information:
Belongs to the unc-5 family &  Contains 1 death domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 2 TSP type-1 domains &  Contains 1 ZU5 domain


uniprot_information_type:
SwissProt: Q02224 # The protein is composed of a N-terminal kinesin-motor domain involved in the chromosome movements, a long coil-coiled region involved in the homodimerization and an inhibitory C-tail involved in autoinhibition of the N-terminal catalytic part (By similarity)# Belongs to the kinesin-like protein family &  Contains 1 kinesin-motor domain &  Contains 25 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q02224 # The protein is composed of a N-terminal kinesin-motor domain involved in the chromosome movements, a long coil-coiled region involved in the homodimerization and an inhibitory C-tail involved in autoinhibition of the N-terminal catalytic part (By similarity)# Belongs to the kinesin-like protein family &  Contains 1 kinesin-motor domain &  Contains 25 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q9UBU2 # The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)# Belongs to the dickkopf family

uniprot_information:
SwissProt: Q9UBU2 # The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)# Belongs to the dickkopf family


uniprot_information_type: SwissProt: O43252
uniprot_information:
In the N-terminal section; belongs to the APS kinase family &  In the C-terminal section; belongs to the sulfate adenylyltransferase family


uniprot_information_type:
SwissProt: Q9UJU2 # Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors# Belongs to the TCF/LEF family &  Contains 1 HMG box DNA-binding domain

uniprot_information:
SwissProt: Q9UJU2 # Proline-rich and acidic regions are implicated in the activation functions of RNA polymerase II transcription factors# Belongs to the TCF/LEF family &  Contains 1 HMG box DNA-binding domain


uniprot_information_type: SwissProt: P05156
uniprot_information:
Belongs to the peptidase S1 family &  Contains 1 Kazal-like domain &  Contains 2 LDL-receptor class A domains &  Contains 1 peptidase S1 domain &  Contains 1 SRCR domain


uniprot_information_type: SwissProt: P56730
uniprot_information:
Belongs to the peptidase S1 family &  Contains 1 kringle domain &  Contains 1 peptidase S1 domain &  Contains 4 SRCR domains


uniprot_information_type:
SwissProt: P12104 # Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

uniprot_information:
SwissProt: P12104 # Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


uniprot_information_type:
SwissProt: O76074 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B# Belongs to the cyclic nucleotide phosphodiesterase family &  Contains 2 GAF domains

uniprot_information:
SwissProt: O76074 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B# Belongs to the cyclic nucleotide phosphodiesterase family &  Contains 2 GAF domains


uniprot_information_type:
SwissProt: Q13257 # The protein has two highly different native conformations, an inactive open conformation that cannot bind CDC20 and that predominates in cytosolic monomers, and an active closed conformation. The protein in the closed conformation preferentially dimerizes with another molecule in the open conformation, but can also form a dimer with a molecule in the closed conformation. Formation of a heterotetrameric core complex containing two molecules of MAD1L1 and of MAD2L1 in the closed conformation promotes binding of another molecule of MAD2L1 in the open conformation and the conversion of the open to the closed form, and thereby promotes interaction with CDC20# Belongs to the MAD2 family &  Contains 1 HORMA domain

uniprot_information:
SwissProt: Q13257 # The protein has two highly different native conformations, an inactive open conformation that cannot bind CDC20 and that predominates in cytosolic monomers, and an active closed conformation. The protein in the closed conformation preferentially dimerizes with another molecule in the open conformation, but can also form a dimer with a molecule in the closed conformation. Formation of a heterotetrameric core complex containing two molecules of MAD1L1 and of MAD2L1 in the closed conformation promotes binding of another molecule of MAD2L1 in the open conformation and the conversion of the open to the closed form, and thereby promotes interaction with CDC20# Belongs to the MAD2 family &  Contains 1 HORMA domain


uniprot_information_type:
SwissProt: P08758 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats

uniprot_information:
SwissProt: P08758 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats


uniprot_information_type: SwissProt: Q13507
uniprot_information:
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily &  Contains 5 ANK repeats


uniprot_information_type:
SwissProt: O15173 # The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161 (By similarity)# Belongs to the cytochrome b5 family. MAPR subfamily &  Contains 1 cytochrome b5 heme-binding domain

uniprot_information:
SwissProt: O15173 # The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161 (By similarity)# Belongs to the cytochrome b5 family. MAPR subfamily &  Contains 1 cytochrome b5 heme-binding domain


uniprot_information_type: SwissProt: Q9UPY5
uniprot_information:
Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family


uniprot_information_type:
SwissProt: P08235 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P08235 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: P02671 # A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure# Contains 1 fibrinogen C-terminal domain

uniprot_information:
SwissProt: P02671 # A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure# Contains 1 fibrinogen C-terminal domain


uniprot_information_type:
SwissProt: P02679 # A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure# Contains 1 fibrinogen C-terminal domain

uniprot_information:
SwissProt: P02679 # A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure# Contains 1 fibrinogen C-terminal domain


uniprot_information_type: SwissProt: Q08752
uniprot_information:
Belongs to the cyclophilin-type PPIase family. PPIase D subfamily &  Contains 1 PPIase cyclophilin-type domain &  Contains 3 TPR repeats


uniprot_information_type:
SwissProt: Q8TCQ1 # The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-CH-type zinc finger

uniprot_information:
SwissProt: Q8TCQ1 # The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-CH-type zinc finger


uniprot_information_type: SwissProt: Q8IY21
uniprot_information:
Belongs to the helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: O75311 # The N-terminal domain carries structural determinants essential for agonist and antagonist binding. TM2 is thought to form the innert wall of the chloride channel. The cytoplasmic loop is an important determinant of channel inactivation kinetics# Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily

uniprot_information:
SwissProt: O75311 # The N-terminal domain carries structural determinants essential for agonist and antagonist binding. TM2 is thought to form the innert wall of the chloride channel. The cytoplasmic loop is an important determinant of channel inactivation kinetics# Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily


uniprot_information_type: SwissProt: Q15928
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 11 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: P22607
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily &  Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O96028
uniprot_information:
Belongs to the histone-lysine methyltransferase family. SET2 subfamily &  Contains 1 AWS domain &  Contains 1 HMG box DNA-binding domain &  Contains 4 PHD-type zinc fingers &  Contains 1 post-SET domain &  Contains 2 PWWP domains &  Contains 1 SET domain


uniprot_information_type:
SwissProt: P35611 # Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region# Belongs to the aldolase class II family. Adducin subfamily

uniprot_information:
SwissProt: P35611 # Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region# Belongs to the aldolase class II family. Adducin subfamily


uniprot_information_type: SwissProt: P32298
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain &  Contains 1 RGS domain


uniprot_information_type:
SwissProt: P42858 # The N-terminal Gln-rich and Pro-rich domain has great conformational flexibility and is likely to exist in a fluctuating equilibrium of alpha-helical, random coil, and extended conformations# Belongs to the huntingtin family &  Contains 10 HEAT repeats

uniprot_information:
SwissProt: P42858 # The N-terminal Gln-rich and Pro-rich domain has great conformational flexibility and is likely to exist in a fluctuating equilibrium of alpha-helical, random coil, and extended conformations# Belongs to the huntingtin family &  Contains 10 HEAT repeats


uniprot_information_type: SwissProt: Q04756
uniprot_information:
Belongs to the peptidase S1 family &  Contains 2 EGF-like domains &  Contains 1 fibronectin type-I domain &  Contains 1 fibronectin type-II domain &  Contains 1 kringle domain &  Contains 1 peptidase S1 domain


uniprot_information_type:
SwissProt: O94813 # The leucine-rich repeat domain is sufficient for guiding both axon projection and neuronal migration, in vitro# Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 7 EGF-like domains &  Contains 1 laminin G-like domain &  Contains 23 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: O94813 # The leucine-rich repeat domain is sufficient for guiding both axon projection and neuronal migration, in vitro# Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 7 EGF-like domains &  Contains 1 laminin G-like domain &  Contains 23 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q9NZH5 # The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway (By similarity)# Belongs to the securin family

uniprot_information:
SwissProt: Q9NZH5 # The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway (By similarity)# Belongs to the securin family


uniprot_information_type:
SwissProt: Q15669 # The region involved in interaction with ZAP70 is a non-canonical immunoreceptor tyrosine-based activation motif (ITAM) (By similarity)# Belongs to the small GTPase superfamily. Rho family

uniprot_information:
SwissProt: Q15669 # The region involved in interaction with ZAP70 is a non-canonical immunoreceptor tyrosine-based activation motif (ITAM) (By similarity)# Belongs to the small GTPase superfamily. Rho family


uniprot_information_type: SwissProt: Q9UPQ0
uniprot_information:
Belongs to the LIMCH1 family &  Contains 1 CH (calponin-homology) domain &  Contains 1 LIM zinc-binding domain


uniprot_information_type: SwissProt: P18505
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily


uniprot_information_type: SwissProt: P16234
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily &  Contains 5 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: P22234
uniprot_information:
In the N-terminal section; belongs to the SAICAR synthetase family &  In the C-terminal section; belongs to the AIR carboxylase family


uniprot_information_type:
SwissProt: O76094 # The C-terminus is essential for the interaction with the SRP68/7S RNA complex (By similarity)# Belongs to the SRP72 family &  Contains 5 TPR repeats

uniprot_information:
SwissProt: O76094 # The C-terminus is essential for the interaction with the SRP68/7S RNA complex (By similarity)# Belongs to the SRP72 family &  Contains 5 TPR repeats


uniprot_information_type:
SwissProt: O60763 # Composed of a globular head, an elongated tail (coiled-coil) and a highly acidic C-terminal domain# Belongs to the VDP/USO1/EDE1 family &  Contains 10 ARM repeats

uniprot_information:
SwissProt: O60763 # Composed of a globular head, an elongated tail (coiled-coil) and a highly acidic C-terminal domain# Belongs to the VDP/USO1/EDE1 family &  Contains 10 ARM repeats


uniprot_information_type:
SwissProt: Q86XX4 # The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding (By similarity)# Belongs to the FRAS1 family &  Contains 5 Calx-beta domains &  Contains 12 CSPG (NG2) repeats &  Contains 14 FU (furin-like) repeats &  Contains 6 VWFC domains

uniprot_information:
SwissProt: Q86XX4 # The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding (By similarity)# Belongs to the FRAS1 family &  Contains 5 Calx-beta domains &  Contains 12 CSPG (NG2) repeats &  Contains 14 FU (furin-like) repeats &  Contains 6 VWFC domains


uniprot_information_type:
SwissProt: P12429 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats

uniprot_information:
SwissProt: P12429 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats


uniprot_information_type:
SwissProt: Q8N264 # The coiled coil domain mediates the interaction with FLNA leading to its recruitment to lamellae# Contains 1 PH domain &  Contains 1 Rho-GAP domain

uniprot_information:
SwissProt: Q8N264 # The coiled coil domain mediates the interaction with FLNA leading to its recruitment to lamellae# Contains 1 PH domain &  Contains 1 Rho-GAP domain


uniprot_information_type: SwissProt: Q12923
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily &  Contains 1 FERM domain &  Contains 1 KIND domain &  Contains 5 PDZ (DHR) domains &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: Q13563 # The C-terminal coiled-coil domain binds calcium and undergoes a calcium-induced conformation change. It is implicated in oligomerization and the interaction with PKD1# Belongs to the polycystin family &  Contains 1 EF-hand domain

uniprot_information:
SwissProt: Q13563 # The C-terminal coiled-coil domain binds calcium and undergoes a calcium-induced conformation change. It is implicated in oligomerization and the interaction with PKD1# Belongs to the polycystin family &  Contains 1 EF-hand domain


uniprot_information_type:
SwissProt: O43424 # The PDZ-binding motif mediates interaction with GOPC (By similarity)# Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily

uniprot_information:
SwissProt: O43424 # The PDZ-binding motif mediates interaction with GOPC (By similarity)# Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily


uniprot_information_type:
SwissProt: P19838 # The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding, and transcription activation &  Glycine-rich region (GRR) appears to be a critical element in the generation of p50# Contains 7 ANK repeats &  Contains 1 death domain &  Contains 1 RHD (Rel-like) domain

uniprot_information:
SwissProt: P19838 # The C-terminus of p105 might be involved in cytoplasmic retention, inhibition of DNA-binding, and transcription activation &  Glycine-rich region (GRR) appears to be a critical element in the generation of p50# Contains 7 ANK repeats &  Contains 1 death domain &  Contains 1 RHD (Rel-like) domain


uniprot_information_type:
SwissProt: Q9NY12 # Interaction with SMN1 requires at least one of the RGG-box regions# Belongs to the GAR1 family

uniprot_information:
SwissProt: Q9NY12 # Interaction with SMN1 requires at least one of the RGG-box regions# Belongs to the GAR1 family


uniprot_information_type: SwissProt: Q96QP1
uniprot_information:
Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily &  Contains 1 alpha-type protein kinase domain


uniprot_information_type:
SwissProt: O43609 # The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles# Belongs to the sprouty family &  Contains 1 SPR (sprouty) domain

uniprot_information:
SwissProt: O43609 # The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles# Belongs to the sprouty family &  Contains 1 SPR (sprouty) domain


uniprot_information_type: SwissProt: O00444
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily &  Contains 1 POLO box domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q6IE81 # The 2 PHD-type zinc fingers are required for transcriptional activity# Belongs to the JADE family &  Contains 2 PHD-type zinc fingers

uniprot_information:
SwissProt: Q6IE81 # The 2 PHD-type zinc fingers are required for transcriptional activity# Belongs to the JADE family &  Contains 2 PHD-type zinc fingers


uniprot_information_type: SwissProt: O60264
uniprot_information:
Belongs to the SNF2/RAD54 helicase family. ISWI subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 2 SANT domains


uniprot_information_type: SwissProt: P61221
uniprot_information:
Belongs to the ABC transporter superfamily. ABCE family &  Contains 2 4Fe-4S ferredoxin-type domains &  Contains 2 ABC transporter domains


uniprot_information_type: SwissProt: Q15797
uniprot_information:
Belongs to the dwarfin/SMAD family &  Contains 1 MH1 (MAD homology 1) domain &  Contains 1 MH2 (MAD homology 2) domain


uniprot_information_type: SwissProt: Q12837
uniprot_information:
Belongs to the POU transcription factor family. Class-4 subfamily &  Contains 1 homeobox DNA-binding domain &  Contains 1 POU-specific domain


uniprot_information_type: SwissProt: P25101
uniprot_information:
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily


uniprot_information_type:
SwissProt: Q9C040 # The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades (By similarity)# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 filamin repeat &  Contains 6 NHL repeats &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q9C040 # The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades (By similarity)# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 filamin repeat &  Contains 6 NHL repeats &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: O60603
uniprot_information:
Belongs to the Toll-like receptor family &  Contains 14 LRR (leucine-rich) repeats &  Contains 1 TIR domain


uniprot_information_type:
SwissProt: P02675 # A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure# Contains 1 fibrinogen C-terminal domain

uniprot_information:
SwissProt: P02675 # A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure# Contains 1 fibrinogen C-terminal domain


uniprot_information_type: SwissProt: Q02108
uniprot_information:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family &  Contains 1 guanylate cyclase domain


uniprot_information_type: SwissProt: P48167
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRB sub-subfamily


uniprot_information_type:
SwissProt: Q15800 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the sterol desaturase family

uniprot_information:
SwissProt: Q15800 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the sterol desaturase family


uniprot_information_type:
SwissProt: P51790 # Isoform 2 contains a C-terminal PDZ-binding motif mediating the interaction with GOPC# Belongs to the chloride channel (TC 2.A.49) family. CLCN3 subfamily &  Contains 2 CBS domains

uniprot_information:
SwissProt: P51790 # Isoform 2 contains a C-terminal PDZ-binding motif mediating the interaction with GOPC# Belongs to the chloride channel (TC 2.A.49) family. CLCN3 subfamily &  Contains 2 CBS domains


uniprot_information_type:
SwissProt: Q86SF2 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q86SF2 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: Q9H160 # The PHD-type zinc finger domain binds to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P)# Belongs to the ING family &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: Q9H160 # The PHD-type zinc finger domain binds to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P)# Belongs to the ING family &  Contains 1 PHD-type zinc finger


uniprot_information_type:
SwissProt: O15455 # ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18 (By similarity)# Belongs to the Toll-like receptor family &  Contains 22 LRR (leucine-rich) repeats &  Contains 1 TIR domain

uniprot_information:
SwissProt: O15455 # ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18 (By similarity)# Belongs to the Toll-like receptor family &  Contains 22 LRR (leucine-rich) repeats &  Contains 1 TIR domain


uniprot_information_type: SwissProt: P03952
uniprot_information:
Belongs to the peptidase S1 family. Plasma kallikrein subfamily &  Contains 4 apple domains &  Contains 1 peptidase S1 domain


uniprot_information_type:
SwissProt: O14746 # The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers &  The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity &  The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA sythesis# Belongs to the reverse transcriptase family. Telomerase subfamily &  Contains 1 reverse transcriptase domain

uniprot_information:
SwissProt: O14746 # The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers &  The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity &  The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA sythesis# Belongs to the reverse transcriptase family. Telomerase subfamily &  Contains 1 reverse transcriptase domain


uniprot_information_type:
SwissProt: Q8NF37 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine (By similarity) &  The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family &  Contains 2 EF-hand domains

uniprot_information:
SwissProt: Q8NF37 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine (By similarity) &  The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family &  Contains 2 EF-hand domains


uniprot_information_type: SwissProt: Q13591
uniprot_information:
Belongs to the semaphorin family &  Contains 1 PSI domain &  Contains 1 Sema domain &  Contains 7 TSP type-1 domains


uniprot_information_type: SwissProt: Q9HD67
uniprot_information:
Contains 1 FERM domain &  Contains 3 IQ domains &  Contains 1 myosin head-like domain &  Contains 1 MyTH4 domain &  Contains 2 PH domains


uniprot_information_type:
SwissProt: Q9NRR4 # The 2 RNase III domains form an intramolecular dimer where the domain 1 cuts the 3'strand while the domain 2 cleaves the 5'strand of pri-miRNAs, independently of each other# Contains 1 DRBM (double-stranded RNA-binding) domain &  Contains 2 RNase III domains

uniprot_information:
SwissProt: Q9NRR4 # The 2 RNase III domains form an intramolecular dimer where the domain 1 cuts the 3'strand while the domain 2 cleaves the 5'strand of pri-miRNAs, independently of each other# Contains 1 DRBM (double-stranded RNA-binding) domain &  Contains 2 RNase III domains


uniprot_information_type:
SwissProt: P58397 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix (By similarity) &  The C-terminal four TSP1-like repeats are necessary and sufficient for binding COMP &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 8 TSP type-1 domains

uniprot_information:
SwissProt: P58397 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix (By similarity) &  The C-terminal four TSP1-like repeats are necessary and sufficient for binding COMP &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 8 TSP type-1 domains


uniprot_information_type:
SwissProt: P16471 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 1 subfamily &  Contains 2 fibronectin type-III domains

uniprot_information:
SwissProt: P16471 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 1 subfamily &  Contains 2 fibronectin type-III domains


uniprot_information_type:
SwissProt: P42702 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 6 fibronectin type-III domains

uniprot_information:
SwissProt: P42702 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 6 fibronectin type-III domains


uniprot_information_type: SwissProt: P02748
uniprot_information:
Belongs to the complement C6/C7/C8/C9 family &  Contains 1 EGF-like domain &  Contains 1 LDL-receptor class A domain &  Contains 1 MACPF domain &  Contains 1 TSP type-1 domain


uniprot_information_type: SwissProt: P13671
uniprot_information:
Belongs to the complement C6/C7/C8/C9 family &  Contains 1 EGF-like domain &  Contains 2 Kazal-like domains &  Contains 1 LDL-receptor class A domain &  Contains 1 MACPF domain &  Contains 2 Sushi (CCP/SCR) domains &  Contains 3 TSP type-1 domains


uniprot_information_type:
SwissProt: Q9H074 # Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation# Contains 1 MIF4G domain

uniprot_information:
SwissProt: Q9H074 # Only the PABPC1-interacting motif-1 (PAM1) stimulates translation initiation# Contains 1 MIF4G domain


uniprot_information_type: SwissProt: Q7Z478
uniprot_information:
Belongs to the DEAD box helicase family. DEAH subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: P40189 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 5 fibronectin type-III domains &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: P40189 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 5 fibronectin type-III domains &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P08908
uniprot_information:
Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily


uniprot_information_type:
SwissProt: Q9UKP5 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 5 TSP type-1 domains

uniprot_information:
SwissProt: Q9UKP5 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 5 TSP type-1 domains


uniprot_information_type:
SwissProt: P36406 # The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity# In the C-terminal section; belongs to the small GTPase superfamily. Arf family &  Contains 1 B box-type zinc finger &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: P36406 # The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity# In the C-terminal section; belongs to the small GTPase superfamily. Arf family &  Contains 1 B box-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9Y5P4 # The START domain recognizes ceramide and mediates the intermembrane transfer of ceramide &  The PH domain targets the Golgi apparatus &  The FFAT motif is required for interaction with VAPA and VAPB# Contains 1 PH domain &  Contains 1 START domain

uniprot_information:
SwissProt: Q9Y5P4 # The START domain recognizes ceramide and mediates the intermembrane transfer of ceramide &  The PH domain targets the Golgi apparatus &  The FFAT motif is required for interaction with VAPA and VAPB# Contains 1 PH domain &  Contains 1 START domain


uniprot_information_type:
SwissProt: Q86YM7 # The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3# Belongs to the Homer family &  Contains 1 WH1 domain

uniprot_information:
SwissProt: Q86YM7 # The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3# Belongs to the Homer family &  Contains 1 WH1 domain


uniprot_information_type:
SwissProt: Q06413 # The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity (By similarity)# Belongs to the MEF2 family &  Contains 1 MADS-box domain &  Contains 1 Mef2-type DNA-binding domain

uniprot_information:
SwissProt: Q06413 # The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity (By similarity)# Belongs to the MEF2 family &  Contains 1 MADS-box domain &  Contains 1 Mef2-type DNA-binding domain


uniprot_information_type: SwissProt: Q9BVS4
uniprot_information:
Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O14646 # The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3)# Belongs to the SNF2/RAD54 helicase family &  Contains 2 chromo domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain

uniprot_information:
SwissProt: O14646 # The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3)# Belongs to the SNF2/RAD54 helicase family &  Contains 2 chromo domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q86UD3 # The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-CH-type zinc finger

uniprot_information:
SwissProt: Q86UD3 # The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-CH-type zinc finger


uniprot_information_type: SwissProt: P35556
uniprot_information:
Belongs to the fibrillin family &  Contains 47 EGF-like domains &  Contains 9 TB (TGF-beta binding) domains


uniprot_information_type:
SwissProt: P49773 # The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide# Belongs to the HINT family &  Contains 1 HIT domain

uniprot_information:
SwissProt: P49773 # The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide# Belongs to the HINT family &  Contains 1 HIT domain


uniprot_information_type: SwissProt: Q8TEU7
uniprot_information:
Contains 1 cyclic nucleotide-binding domain &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 PDZ (DHR) domain &  Contains 1 Ras-associating domain &  Contains 1 Ras-GEF domain


uniprot_information_type: SwissProt: Q6MZW2
uniprot_information:
Contains 1 EF-hand domain &  Contains 2 Ig-like (immunoglobulin-like) domains &  Contains 1 Kazal-like domain


uniprot_information_type:
SwissProt: P21796 # Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity# Belongs to the eukaryotic mitochondrial porin family

uniprot_information:
SwissProt: P21796 # Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity# Belongs to the eukaryotic mitochondrial porin family


uniprot_information_type:
SwissProt: Q8IVW4 # The [NKR]KIAxRE motif seems to be a cyclin-binding region# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q8IVW4 # The [NKR]KIAxRE motif seems to be a cyclin-binding region# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9HCX4
uniprot_information:
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily &  Contains 4 ANK repeats


uniprot_information_type:
SwissProt: O14511 # The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity) &  ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity)# Belongs to the neuregulin family &  Contains 1 EGF-like domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: O14511 # The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity) &  ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity)# Belongs to the neuregulin family &  Contains 1 EGF-like domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q15545 # The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase, which methylates Lys-5 in vitro (By similarity)# Belongs to the TAF7 family

uniprot_information:
SwissProt: Q15545 # The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase, which methylates Lys-5 in vitro (By similarity)# Belongs to the TAF7 family


uniprot_information_type:
SwissProt: O60610 # DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction (By similarity). WDR68 binds to the FH2 (formin homology 2) domain# Belongs to the formin homology family. Diaphanous subfamily &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain

uniprot_information:
SwissProt: O60610 # DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction (By similarity). WDR68 binds to the FH2 (formin homology 2) domain# Belongs to the formin homology family. Diaphanous subfamily &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


uniprot_information_type: SwissProt: Q8WWN8
uniprot_information:
Contains 1 Arf-GAP domain &  Contains 3 PH domains &  Contains 1 Ras-associating domain &  Contains 1 Rho-GAP domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: Q9C004 # The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles# Belongs to the sprouty family &  Contains 1 SPR (sprouty) domain

uniprot_information:
SwissProt: Q9C004 # The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles# Belongs to the sprouty family &  Contains 1 SPR (sprouty) domain


uniprot_information_type:
SwissProt: P04150 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P04150 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: Q00005 # The N-terminal 26 residues of isoform 2 constitute a cryptic mitochondrial matrix import signal with critical basic and hydrophobic residues, that is necessary and sufficient for targeting the PP2A holoenzyme to the outer mitochondrial membrane (OMM) and does not affect holoenzyme formation or catalytic activity (By similarity) &  The last WD repeat of isoform 2 constitutes a mitochondrial stop-transfer domain that confers resistance to the unfolding step process required for import and therefore prevents PPP2R2B matrix translocation and signal sequence cleavage (By similarity)# Belongs to the phosphatase 2A regulatory subunit B family &  Contains 7 WD repeats

uniprot_information:
SwissProt: Q00005 # The N-terminal 26 residues of isoform 2 constitute a cryptic mitochondrial matrix import signal with critical basic and hydrophobic residues, that is necessary and sufficient for targeting the PP2A holoenzyme to the outer mitochondrial membrane (OMM) and does not affect holoenzyme formation or catalytic activity (By similarity) &  The last WD repeat of isoform 2 constitutes a mitochondrial stop-transfer domain that confers resistance to the unfolding step process required for import and therefore prevents PPP2R2B matrix translocation and signal sequence cleavage (By similarity)# Belongs to the phosphatase 2A regulatory subunit B family &  Contains 7 WD repeats


uniprot_information_type: SwissProt: P48729
uniprot_information:
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9UQM7
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9NW64
uniprot_information:
Belongs to the SLT11 family &  Contains 1 C3H1-type zinc finger &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: P08133 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 8 annexin repeats

uniprot_information:
SwissProt: P08133 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 8 annexin repeats


uniprot_information_type: SwissProt: P23415
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily


uniprot_information_type: SwissProt: Q96D42
uniprot_information:
Belongs to the immunoglobulin superfamily. TIM family &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q9H013 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: Q9H013 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain


uniprot_information_type: SwissProt: P29460
uniprot_information:
Belongs to the type I cytokine receptor family. Type 3 subfamily &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P47870
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily


uniprot_information_type: SwissProt: O75094
uniprot_information:
Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 9 EGF-like domains &  Contains 1 laminin G-like domain &  Contains 23 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: P52790 # The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus# Belongs to the hexokinase family

uniprot_information:
SwissProt: P52790 # The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus# Belongs to the hexokinase family


uniprot_information_type:
SwissProt: Q96RL1 # The UIM-linker region between the 2 UIM repeats determines the selectivity for 'Lys-63'-linked ubiquitin. The length of the linker is important. The linker reduces the flexibility between the UIM repeats and promotes high-affinity and linkage-selective interactions &  The Abraxas-interacting region (AIR) mediates the interaction with FAM175A/Abraxas# Belongs to the RAP80 family &  Contains 2 UIM (ubiquitin-interacting motif) repeats

uniprot_information:
SwissProt: Q96RL1 # The UIM-linker region between the 2 UIM repeats determines the selectivity for 'Lys-63'-linked ubiquitin. The length of the linker is important. The linker reduces the flexibility between the UIM repeats and promotes high-affinity and linkage-selective interactions &  The Abraxas-interacting region (AIR) mediates the interaction with FAM175A/Abraxas# Belongs to the RAP80 family &  Contains 2 UIM (ubiquitin-interacting motif) repeats


uniprot_information_type:
SwissProt: Q9NR12 # The LIM zinc-binding 2 (LIM 2) domain interacts with TBX4 (By similarity) &  The LIM zinc-binding 3 (LIM 3) domain provides the structural basis for recognition of tyrosine-containing tight turn structures. This domain is necessary and sufficient for interaction with TBX5 (By similarity) &  Anchored to cell periphery via its N-terminal PDZ domain# Contains 3 LIM zinc-binding domains &  Contains 1 PDZ (DHR) domain

uniprot_information:
SwissProt: Q9NR12 # The LIM zinc-binding 2 (LIM 2) domain interacts with TBX4 (By similarity) &  The LIM zinc-binding 3 (LIM 3) domain provides the structural basis for recognition of tyrosine-containing tight turn structures. This domain is necessary and sufficient for interaction with TBX5 (By similarity) &  Anchored to cell periphery via its N-terminal PDZ domain# Contains 3 LIM zinc-binding domains &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: Q7L591 # PTB domain mediates receptor interaction (By similarity)# Belongs to the DOK family. Type A subfamily &  Contains 1 IRS-type PTB domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q7L591 # PTB domain mediates receptor interaction (By similarity)# Belongs to the DOK family. Type A subfamily &  Contains 1 IRS-type PTB domain &  Contains 1 PH domain


uniprot_information_type: SwissProt: Q9UJV9
uniprot_information:
Belongs to the DEAD box helicase family. DDX41 subfamily &  Contains 1 CCHC-type zinc finger &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: O95450 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 4 TSP type-1 domains

uniprot_information:
SwissProt: O95450 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 4 TSP type-1 domains


uniprot_information_type:
SwissProt: P31943 # Each quasi-RRM repeat bound poly(RG), while only the N-terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA)# Contains 3 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: P31943 # Each quasi-RRM repeat bound poly(RG), while only the N-terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA)# Contains 3 RRM (RNA recognition motif) domains


uniprot_information_type:
SwissProt: P45984 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P45984 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P63244 # The WD repeats domain 5 mediates interaction with TRIM63# Belongs to the WD repeat G protein beta family &  Contains 7 WD repeats

uniprot_information:
SwissProt: P63244 # The WD repeats domain 5 mediates interaction with TRIM63# Belongs to the WD repeat G protein beta family &  Contains 7 WD repeats


uniprot_information_type: SwissProt: Q96A61
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: O60337 # The RING-CH-type zinc finger domain is required for E3 ligase activity# Contains 1 RING-CH-type zinc finger

uniprot_information:
SwissProt: O60337 # The RING-CH-type zinc finger domain is required for E3 ligase activity# Contains 1 RING-CH-type zinc finger


uniprot_information_type:
SwissProt: O75962 # The N-terminal DBL/GEF domain specifically catalyzes nucleotide exchange for RAC1, leading to the activation of Jun kinase and the production of membrane ruffles. The second DBL/GEF domain is an exchange factor for rhoa and induces the formation of stress fibers# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 CRAL-TRIO domain &  Contains 2 DH (DBL-homology) domains &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 2 PH domains &  Contains 1 protein kinase domain &  Contains 2 SH3 domains &  Contains 4 spectrin repeats

uniprot_information:
SwissProt: O75962 # The N-terminal DBL/GEF domain specifically catalyzes nucleotide exchange for RAC1, leading to the activation of Jun kinase and the production of membrane ruffles. The second DBL/GEF domain is an exchange factor for rhoa and induces the formation of stress fibers# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 CRAL-TRIO domain &  Contains 2 DH (DBL-homology) domains &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 2 PH domains &  Contains 1 protein kinase domain &  Contains 2 SH3 domains &  Contains 4 spectrin repeats


uniprot_information_type:
SwissProt: P16871 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 4 subfamily &  Contains 1 fibronectin type-III domain

uniprot_information:
SwissProt: P16871 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 4 subfamily &  Contains 1 fibronectin type-III domain


uniprot_information_type:
SwissProt: Q6KC79 # Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Belongs to the SCC2/Nipped-B family &  Contains 5 HEAT repeats

uniprot_information:
SwissProt: Q6KC79 # Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Belongs to the SCC2/Nipped-B family &  Contains 5 HEAT repeats


uniprot_information_type:
SwissProt: Q99650 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding (By similarity) &  The box 1 motif is required for JAK interaction and/or activation (By similarity)# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 4 fibronectin type-III domains

uniprot_information:
SwissProt: Q99650 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding (By similarity) &  The box 1 motif is required for JAK interaction and/or activation (By similarity)# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 4 fibronectin type-III domains


uniprot_information_type: SwissProt: P10643
uniprot_information:
Belongs to the complement C6/C7/C8/C9 family &  Contains 1 EGF-like domain &  Contains 1 LDL-receptor class A domain &  Contains 1 MACPF domain &  Contains 2 Sushi (CCP/SCR) domains &  Contains 2 TSP type-1 domains


uniprot_information_type:
SwissProt: P10912 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation &  The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP) &  The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization# Belongs to the type I cytokine receptor family. Type 1 subfamily &  Contains 1 fibronectin type-III domain

uniprot_information:
SwissProt: P10912 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation &  The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP) &  The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization# Belongs to the type I cytokine receptor family. Type 1 subfamily &  Contains 1 fibronectin type-III domain


uniprot_information_type: SwissProt: Q13423
uniprot_information:
In the N-terminal section; belongs to the AlaDH/PNT family &  In the C-terminal section; belongs to the PNT beta subunit family


uniprot_information_type:
SwissProt: P56199 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain

uniprot_information:
SwissProt: P56199 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q9BRX2 # The N-terminal domain has the RNA-binding Sm fold. It may harbor the endoribonuclease activity (Potential)# Belongs to the eukaryotic release factor 1 family. Pelota subfamily

uniprot_information:
SwissProt: Q9BRX2 # The N-terminal domain has the RNA-binding Sm fold. It may harbor the endoribonuclease activity (Potential)# Belongs to the eukaryotic release factor 1 family. Pelota subfamily


uniprot_information_type:
SwissProt: P17301 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain

uniprot_information:
SwissProt: P17301 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain


uniprot_information_type: SwissProt: P19883
uniprot_information:
Contains 3 follistatin-like domains &  Contains 3 Kazal-like domains &  Contains 1 TB (TGF-beta binding) domain


uniprot_information_type: SwissProt: P42285
uniprot_information:
Belongs to the helicase family. SKI2 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: Q9NQI0
uniprot_information:
Belongs to the DEAD box helicase family. DDX4/VASA subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: Q13233
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily &  Contains 1 protein kinase domain &  Contains 1 RING-type zinc finger &  Contains 1 SWIM-type zinc finger


uniprot_information_type: SwissProt: Q96BP3
uniprot_information:
Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily &  Contains 1 PPIase cyclophilin-type domain &  Contains 4 WD repeats


uniprot_information_type: SwissProt: Q96RT1
uniprot_information:
Belongs to the LAP (LRR and PDZ) protein family &  Contains 17 LRR (leucine-rich) repeats &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: P27986 # The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef# Belongs to the PI3K p85 subunit family &  Contains 1 Rho-GAP domain &  Contains 2 SH2 domains &  Contains 1 SH3 domain

uniprot_information:
SwissProt: P27986 # The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef# Belongs to the PI3K p85 subunit family &  Contains 1 Rho-GAP domain &  Contains 2 SH2 domains &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q16625 # The C-terminal is cytoplasmic and is important for interaction with ZO-1. Sufficient for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction (By similarity). The first extracellular loop participates in an adhesive interaction# Belongs to the ELL/occludin family &  Contains 1 MARVEL domain

uniprot_information:
SwissProt: Q16625 # The C-terminal is cytoplasmic and is important for interaction with ZO-1. Sufficient for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction (By similarity). The first extracellular loop participates in an adhesive interaction# Belongs to the ELL/occludin family &  Contains 1 MARVEL domain


uniprot_information_type:
SwissProt: P46821 # Has a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed intervals, which is responsible for the binding of MAP1B to microtubules# Belongs to the MAP1 family

uniprot_information:
SwissProt: P46821 # Has a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed intervals, which is responsible for the binding of MAP1B to microtubules# Belongs to the MAP1 family


uniprot_information_type: SwissProt: Q92973
uniprot_information:
Belongs to the importin beta family &  Contains 8 HEAT repeats &  Contains 1 importin N-terminal domain


uniprot_information_type: SwissProt: Q8N1W1
uniprot_information:
Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger


uniprot_information_type: SwissProt: Q13576
uniprot_information:
Contains 1 CH (calponin-homology) domain &  Contains 3 IQ domains &  Contains 1 Ras-GAP domain &  Contains 1 WW domain


uniprot_information_type:
SwissProt: O95263 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain# Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily &  Contains 1 PAS (PER-ARNT-SIM) domain

uniprot_information:
SwissProt: O95263 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain# Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily &  Contains 1 PAS (PER-ARNT-SIM) domain


uniprot_information_type:
SwissProt: Q7Z3T8 # The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P# Contains 1 FYVE-type zinc finger

uniprot_information:
SwissProt: Q7Z3T8 # The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P# Contains 1 FYVE-type zinc finger


uniprot_information_type: SwissProt: P13611
uniprot_information:
Belongs to the aggrecan/versican proteoglycan family &  Contains 1 C-type lectin domain &  Contains 2 EGF-like domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain &  Contains 2 Link domains &  Contains 1 Sushi (CCP/SCR) domain


uniprot_information_type: SwissProt: P20936
uniprot_information:
Contains 1 C2 domain &  Contains 1 PH domain &  Contains 1 Ras-GAP domain &  Contains 2 SH2 domains &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: O94955 # Although predicted to be a GTP-binding protein because of the presence of a Rho-like region, binds and hydrolyzes ATP. In contrast to Rho-like proteins, the conserved Asp residue in position 138 in the G4 region is replaced by an Asn, decreasing the ability to bind GTP# Contains 2 BTB (POZ) domains

uniprot_information:
SwissProt: O94955 # Although predicted to be a GTP-binding protein because of the presence of a Rho-like region, binds and hydrolyzes ATP. In contrast to Rho-like proteins, the conserved Asp residue in position 138 in the G4 region is replaced by an Asn, decreasing the ability to bind GTP# Contains 2 BTB (POZ) domains


uniprot_information_type: SwissProt: P16591
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily &  Contains 1 FCH domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain


uniprot_information_type:
SwissProt: P25054 # The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends (By similarity)# Belongs to the adenomatous polyposis coli (APC) family &  Contains 7 ARM repeats

uniprot_information:
SwissProt: P25054 # The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends (By similarity)# Belongs to the adenomatous polyposis coli (APC) family &  Contains 7 ARM repeats


uniprot_information_type: SwissProt: Q9H6S0
uniprot_information:
Belongs to the DEAD box helicase family. DEAH subfamily &  Contains 2 ANK repeats &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 R3H domain &  Contains 1 YTH domain


uniprot_information_type:
SwissProt: Q92878 # The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another RAD50 molecule, thereby forming a V-shaped homodimer. The two heads of the homodimer, which constitute the ATP-binding domain, interact with the MRE11A homodimer (By similarity)# Belongs to the SMC family. RAD50 subfamily &  Contains 1 zinc-hook domain

uniprot_information:
SwissProt: Q92878 # The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another RAD50 molecule, thereby forming a V-shaped homodimer. The two heads of the homodimer, which constitute the ATP-binding domain, interact with the MRE11A homodimer (By similarity)# Belongs to the SMC family. RAD50 subfamily &  Contains 1 zinc-hook domain


uniprot_information_type: SwissProt: Q7L014
uniprot_information:
Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q7LBC6 # Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity)# Belongs to the JHDM2 histone demethylase family &  Contains 1 JmjC domain

uniprot_information:
SwissProt: Q7LBC6 # Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity)# Belongs to the JHDM2 histone demethylase family &  Contains 1 JmjC domain


uniprot_information_type:
SwissProt: Q9UBS8 # The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway (By similarity) &  The RING-type zinc finger is essential for the interaction with UBE2E2# Belongs to the RBR family. RNF14 subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers &  Contains 1 RWD domain

uniprot_information:
SwissProt: Q9UBS8 # The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway (By similarity) &  The RING-type zinc finger is essential for the interaction with UBE2E2# Belongs to the RBR family. RNF14 subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers &  Contains 1 RWD domain


uniprot_information_type:
SwissProt: Q9BT67 # The PY (WW-binding) motifs are required for E3 ubiquitin-protein ligase binding and activation and for ubiquitination#

uniprot_information:
SwissProt: Q9BT67 # The PY (WW-binding) motifs are required for E3 ubiquitin-protein ligase binding and activation and for ubiquitination#


uniprot_information_type:
SwissProt: O14776 # The FF domains bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II, probably mediate interaction with HTATSF1 and preferentially bind peptides with the consensus sequence [DE](2-5)-[FWY]-[DE](2-5) &  The WW domains bind Pro-rich domains# Contains 6 FF domains &  Contains 3 WW domains

uniprot_information:
SwissProt: O14776 # The FF domains bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II, probably mediate interaction with HTATSF1 and preferentially bind peptides with the consensus sequence [DE](2-5)-[FWY]-[DE](2-5) &  The WW domains bind Pro-rich domains# Contains 6 FF domains &  Contains 3 WW domains


uniprot_information_type:
SwissProt: Q9NQ38 # Contains at least one active inhibitory domain for trypsin (domain 6)# Contains 15 Kazal-like domains

uniprot_information:
SwissProt: Q9NQ38 # Contains at least one active inhibitory domain for trypsin (domain 6)# Contains 15 Kazal-like domains


uniprot_information_type:
SwissProt: Q6PIJ6 # The N-terminal region aa 1-349 seems to be involved in cytoplasmic localization (By similarity) &  The C-terminal region aa 473-1194 seems to be involved in nuclear localization (By similarity)# Contains 1 F-box domain

uniprot_information:
SwissProt: Q6PIJ6 # The N-terminal region aa 1-349 seems to be involved in cytoplasmic localization (By similarity) &  The C-terminal region aa 473-1194 seems to be involved in nuclear localization (By similarity)# Contains 1 F-box domain


uniprot_information_type:
SwissProt: Q13283 # The NTF2 domain mediates multimerization# Contains 1 NTF2 domain &  Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q13283 # The NTF2 domain mediates multimerization# Contains 1 NTF2 domain &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: Q86SR1 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q86SR1 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: P51161 # Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

uniprot_information:
SwissProt: P51161 # Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


uniprot_information_type:
SwissProt: O95997 # The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway (By similarity) &  The TEK-boxes are required for 'Lys-11'-linked ubiquitination and facilitate the transfer of the first ubiquitin and ubiquitin chain nucleation. TEK-boxes may direct a catalytically competent orientation of the UBE2C/UBCH10-ubiquitin thiolester with the acceptor lysine residue# Belongs to the securin family

uniprot_information:
SwissProt: O95997 # The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway (By similarity) &  The TEK-boxes are required for 'Lys-11'-linked ubiquitination and facilitate the transfer of the first ubiquitin and ubiquitin chain nucleation. TEK-boxes may direct a catalytically competent orientation of the UBE2C/UBCH10-ubiquitin thiolester with the acceptor lysine residue# Belongs to the securin family


uniprot_information_type: SwissProt: Q16445
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily


uniprot_information_type: SwissProt: P14867
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily


uniprot_information_type: SwissProt: P18507
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily


uniprot_information_type:
SwissProt: Q8IX03 # The C2-domain mediates homodimerization# Belongs to the WWC family. KIBRA subfamily &  Contains 1 C2 domain &  Contains 2 WW domains

uniprot_information:
SwissProt: Q8IX03 # The C2-domain mediates homodimerization# Belongs to the WWC family. KIBRA subfamily &  Contains 1 C2 domain &  Contains 2 WW domains


uniprot_information_type:
SwissProt: P54136 # The N-terminus (AA 1-72) has two regions predicted to be alpha-helical that might be involved in the multisynthetase complex assembly# Belongs to the class-I aminoacyl-tRNA synthetase family

uniprot_information:
SwissProt: P54136 # The N-terminus (AA 1-72) has two regions predicted to be alpha-helical that might be involved in the multisynthetase complex assembly# Belongs to the class-I aminoacyl-tRNA synthetase family


uniprot_information_type:
SwissProt: Q92608 # The DHR-2 domain may mediate the GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q92608 # The DHR-2 domain may mediate the GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: O00591
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRP sub-subfamily


uniprot_information_type:
SwissProt: Q96T51 # The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate (By similarity)# Contains 1 FYVE-type zinc finger &  Contains 1 RUN domain

uniprot_information:
SwissProt: Q96T51 # The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate (By similarity)# Contains 1 FYVE-type zinc finger &  Contains 1 RUN domain


uniprot_information_type:
SwissProt: Q96KP1 # Interacts with RALA through the TIG domain (By similarity)# Belongs to the SEC5 family &  Contains 1 IPT/TIG domain

uniprot_information:
SwissProt: Q96KP1 # Interacts with RALA through the TIG domain (By similarity)# Belongs to the SEC5 family &  Contains 1 IPT/TIG domain


uniprot_information_type:
SwissProt: P30740 # Reactive bond 1 is specific for reaction with chymotrypsin-like protease such as cathepsin G, chymotrypsin or chymase, while reactive bond 2 is specific for reaction with elastase-like protease such as neutrophyl elastase, proteinase-3, pancreatic elastase or PSA# Belongs to the serpin family. Ov-serpin subfamily

uniprot_information:
SwissProt: P30740 # Reactive bond 1 is specific for reaction with chymotrypsin-like protease such as cathepsin G, chymotrypsin or chymase, while reactive bond 2 is specific for reaction with elastase-like protease such as neutrophyl elastase, proteinase-3, pancreatic elastase or PSA# Belongs to the serpin family. Ov-serpin subfamily


uniprot_information_type: SwissProt: O75521
uniprot_information:
In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family &  Contains 1 ACB (acyl-CoA-binding) domain


uniprot_information_type:
SwissProt: P43307 # Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged# Belongs to the TRAP-alpha family

uniprot_information:
SwissProt: P43307 # Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged# Belongs to the TRAP-alpha family


uniprot_information_type:
SwissProt: P05549 # The WW-binding motif mediates interaction with WWOX (By similarity)# Belongs to the AP-2 family

uniprot_information:
SwissProt: P05549 # The WW-binding motif mediates interaction with WWOX (By similarity)# Belongs to the AP-2 family


uniprot_information_type:
SwissProt: Q9NXB9 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the ELO family

uniprot_information:
SwissProt: Q9NXB9 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the ELO family


uniprot_information_type:
SwissProt: Q14511 # Contains a central domain containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif confers specific interaction with the HLH proteins ID2, E12 and E47. It is absolutely required for the induction of pseudohyphal growth in yeast and mediates homodimerization and heterodimerization with p130cas &  The SH3 domain interacts with two proline-rich regions of focal adhesion kinase# Belongs to the CAS family &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q14511 # Contains a central domain containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif confers specific interaction with the HLH proteins ID2, E12 and E47. It is absolutely required for the induction of pseudohyphal growth in yeast and mediates homodimerization and heterodimerization with p130cas &  The SH3 domain interacts with two proline-rich regions of focal adhesion kinase# Belongs to the CAS family &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q96S59 # The SPRY domain mediates the interaction with MET, AR, and CDC2L1# Belongs to the RANBP9/10 family &  Contains 1 B30.2/SPRY domain &  Contains 1 CTLH domain &  Contains 1 LisH domain

uniprot_information:
SwissProt: Q96S59 # The SPRY domain mediates the interaction with MET, AR, and CDC2L1# Belongs to the RANBP9/10 family &  Contains 1 B30.2/SPRY domain &  Contains 1 CTLH domain &  Contains 1 LisH domain


uniprot_information_type:
SwissProt: P54253 # The AXH domain is required for interaction with CIC (By similarity)# Belongs to the ATXN1 family &  Contains 1 AXH domain

uniprot_information:
SwissProt: P54253 # The AXH domain is required for interaction with CIC (By similarity)# Belongs to the ATXN1 family &  Contains 1 AXH domain


uniprot_information_type: SwissProt: Q99676
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 19 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: Q969J2
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 7 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: Q96LW9
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 6 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: O43309
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 11 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type:
SwissProt: P14373 # The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: P14373 # The coiled-coil region mediates interaction with EPC1 and CHD4. The B box and coiled-coil domains mediate interaction with PML. The B box and the distal coiled-coil domains mediate homomultimerisation. The B30.2 domain mediates interaction with EIF3S6# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9UBS5 # Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 2. The linker region between the transmembrane domain 3 (TM3) and the transmembrane domain 4 (TM4) probably play a role in the specificity for G-protein coupling# Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily &  Contains 2 Sushi (CCP/SCR) domains

uniprot_information:
SwissProt: Q9UBS5 # Alpha-helical parts of the C-terminal intracellular region mediate heterodimeric interaction with GABA-B receptor 2. The linker region between the transmembrane domain 3 (TM3) and the transmembrane domain 4 (TM4) probably play a role in the specificity for G-protein coupling# Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily &  Contains 2 Sushi (CCP/SCR) domains


uniprot_information_type:
SwissProt: P36915 # In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern# Belongs to the MMR1/HSR1 GTP-binding protein family

uniprot_information:
SwissProt: P36915 # In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern# Belongs to the MMR1/HSR1 GTP-binding protein family


uniprot_information_type:
SwissProt: Q01860 # The POU-specific domain mediates interaction with PKM2# Belongs to the POU transcription factor family. Class-5 subfamily &  Contains 1 homeobox DNA-binding domain &  Contains 1 POU-specific domain

uniprot_information:
SwissProt: Q01860 # The POU-specific domain mediates interaction with PKM2# Belongs to the POU transcription factor family. Class-5 subfamily &  Contains 1 homeobox DNA-binding domain &  Contains 1 POU-specific domain


uniprot_information_type: SwissProt: O14931
uniprot_information:
Belongs to the natural cytotoxicity receptor (NCR) family &  Contains 1 Ig-like (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: O00299 # Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion# Belongs to the chloride channel CLIC family &  Contains 1 GST C-terminal domain

uniprot_information:
SwissProt: O00299 # Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion# Belongs to the chloride channel CLIC family &  Contains 1 GST C-terminal domain


uniprot_information_type:
SwissProt: Q99519 # A C-terminal internalization signal (YGTL) appears to allow the targeting of plasma membrane proteins to endosomes# Belongs to the glycosyl hydrolase 33 family &  Contains 4 BNR repeats

uniprot_information:
SwissProt: Q99519 # A C-terminal internalization signal (YGTL) appears to allow the targeting of plasma membrane proteins to endosomes# Belongs to the glycosyl hydrolase 33 family &  Contains 4 BNR repeats


uniprot_information_type:
SwissProt: Q99941 # The basic domain functions as a nuclear localization signal &  The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE# Belongs to the bZIP family. ATF subfamily &  Contains 1 bZIP domain

uniprot_information:
SwissProt: Q99941 # The basic domain functions as a nuclear localization signal &  The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE# Belongs to the bZIP family. ATF subfamily &  Contains 1 bZIP domain


uniprot_information_type:
SwissProt: Q99943 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

uniprot_information:
SwissProt: Q99943 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


