# gene_info

symbol: ST6GALNAC3
gene_name:
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3


symbol: SEMA4A
gene_name:
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


symbol: SRD5A2
gene_name:
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)


symbol: SLC3A1
gene_name:
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1


symbol: SEMA4F
gene_name:
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F


symbol: SMARCAD1
gene_name:
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1


symbol: SEMA5A
gene_name:
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A


symbol: CMAH
gene_name:
cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMP-N-acetylneuraminate monooxygenase) pseudogene


symbol: SEMA4D
gene_name:
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D


symbol: ST6GALNAC6
gene_name:
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6


symbol: ST6GALNAC4
gene_name:
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4


symbol: AMMECR1
gene_name:
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1


symbol: FLT1
gene_name:
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)


symbol: SEMA4B
gene_name:
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B


symbol: ST6GALNAC1
gene_name:
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1


symbol: ERBB2
gene_name:
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)


symbol: ERCC1
gene_name:
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)


symbol: GART
gene_name:
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase


# alias

alias_symbol:
Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex


alias_symbol:
dihydrolipoamide branched chain transacylase (E2 component of branched chain keto acid dehydrogenase complex; maple syrup urine disease)


alias_symbol:
lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial


alias_symbol:
dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex


alias_symbol:
lipoamide acyltransferase component of mitochondrial branched-chain alpha-keto acid dehydrogenase complex


alias_symbol:
AUT (S. cerevisiae)-like 1, cysteine endopeptidase; AUT-like 1, cysteine endopeptidase (S. cerevisiae)


alias_symbol:
sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C


alias_symbol:
nuclear protein, marker for differentiated aortic smooth muscle and down-regulated with vascular injury


alias_symbol:
CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II)


alias_symbol:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1


alias_symbol:
dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex)


alias_symbol:
E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex


alias_symbol:
Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase


alias_symbol:
glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase


alias_symbol:
protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), beta isoform (calcineurin B, type II)


alias_symbol:
protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, beta isoform (calcineurin B, type II)


alias_symbol:
sialytransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialytransferase) F


alias_symbol:
sialyltransferase 7D ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase)


alias_symbol:
alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase


alias_symbol:
phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)


alias_symbol:
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN


alias_symbol:
BTB (broad-complex tramtrack and bric-a-brac/pox virus and zinc finger) domain-containing protein 10


alias_symbol:
asparagine-linked glycosylation 9, alpha- 1,2-mannosyltransferase homolog (S. cerevisiae, alpha- 1,2-mannosyltransferase)


alias_symbol:
SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate


alias_symbol:
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15, preproprotein


alias_symbol:
REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein


alias_symbol:
sodium/chloride dependent neurotransmitter transporter Homo sapiens orphan neurotransmitter transporter NTT7


alias_symbol:
Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3)


alias_symbol:
sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) A


alias_symbol:
protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)


alias_symbol:
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)


alias_symbol:
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)


alias_symbol:
integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit)


# uniprot

uniprot_information_type:
SwissProt: Q9HCC6 # Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) (By similarity) &  The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain

uniprot_information:
SwissProt: Q9HCC6 # Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) (By similarity) &  The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain


uniprot_information_type:
SwissProt: Q5TA45 # The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex (By similarity)# Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily

uniprot_information:
SwissProt: Q5TA45 # The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex (By similarity)# Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily


uniprot_information_type:
SwissProt: Q96S94 # Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity)# Belongs to the cyclin family. Cyclin L subfamily

uniprot_information:
SwissProt: Q96S94 # Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity)# Belongs to the cyclin family. Cyclin L subfamily


uniprot_information_type:
SwissProt: Q5TA89 # Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) (By similarity) &  The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain

uniprot_information:
SwissProt: Q5TA89 # Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) (By similarity) &  The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain


uniprot_information_type:
SwissProt: Q9Y543 # Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) &  The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain

uniprot_information:
SwissProt: Q9Y543 # Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) &  The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain


uniprot_information_type:
SwissProt: Q9UJM3 # The EGFR-binding region prevents binding of a cyclin-like activator to the EGFR kinase domain, and thereby keeps EGFR in an inactive conformation. Also maintains EGFR in an inactive conformation by preventing formation of an asymmetric homodimer# Belongs to the MIG6 family

uniprot_information:
SwissProt: Q9UJM3 # The EGFR-binding region prevents binding of a cyclin-like activator to the EGFR kinase domain, and thereby keeps EGFR in an inactive conformation. Also maintains EGFR in an inactive conformation by preventing formation of an asymmetric homodimer# Belongs to the MIG6 family


uniprot_information_type: SwissProt: P22732
uniprot_information:
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily


uniprot_information_type: SwissProt: Q9C0F3
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 12 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: O75764
uniprot_information:
Belongs to the TFS-II family &  Contains 1 TFIIS central domain &  Contains 1 TFIIS N-terminal domain &  Contains 1 TFIIS-type zinc finger


uniprot_information_type:
SwissProt: Q13761 # A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes# Contains 1 Runt domain

uniprot_information:
SwissProt: Q13761 # A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes# Contains 1 Runt domain


uniprot_information_type:
SwissProt: Q969Q1 # The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity (By similarity)# Contains 1 B box-type zinc finger &  Contains 1 COS domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q969Q1 # The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity (By similarity)# Contains 1 B box-type zinc finger &  Contains 1 COS domain &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: O95382
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9Y6W5 # Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain# Belongs to the SCAR/WAVE family &  Contains 1 WH2 domain

uniprot_information:
SwissProt: Q9Y6W5 # Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain# Belongs to the SCAR/WAVE family &  Contains 1 WH2 domain


uniprot_information_type:
SwissProt: Q8IXK0 # HD1 motif interacts with SAM domain of PHC1# Contains 1 FCS-type zinc finger &  Contains 1 SAM (sterile alpha motif) domain

uniprot_information:
SwissProt: Q8IXK0 # HD1 motif interacts with SAM domain of PHC1# Contains 1 FCS-type zinc finger &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type: SwissProt: Q8N2I9
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q2MKA7 # The FU repeats are required for activation and stabilization of beta-catenin (By similarity)# Belongs to the R-spondin family &  Contains 2 FU (furin-like) repeats &  Contains 1 TSP type-1 domain

uniprot_information:
SwissProt: Q2MKA7 # The FU repeats are required for activation and stabilization of beta-catenin (By similarity)# Belongs to the R-spondin family &  Contains 2 FU (furin-like) repeats &  Contains 1 TSP type-1 domain


uniprot_information_type: SwissProt: Q9NQ87
uniprot_information:
Belongs to the HEY family &  Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain


uniprot_information_type:
SwissProt: Q5T1R4 # The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures (By similarity)# Contains 5 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q5T1R4 # The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures (By similarity)# Contains 5 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q8WZA1 # Amino acid residues between 299-311 are important for both protein expression and enzymatic activity. The minimal catalytic domain is located between positions 299-651. Single amino acid substitutions in the stem domain from MEB patients abolished the activity of the membrane-bound form but not the soluble form. This suggests that the stem domain of the soluble form is unnecessary for activity, but that some amino acids play a crucial role in the membrane-bound form# Belongs to the glycosyltransferase 13 family

uniprot_information:
SwissProt: Q8WZA1 # Amino acid residues between 299-311 are important for both protein expression and enzymatic activity. The minimal catalytic domain is located between positions 299-651. Single amino acid substitutions in the stem domain from MEB patients abolished the activity of the membrane-bound form but not the soluble form. This suggests that the stem domain of the soluble form is unnecessary for activity, but that some amino acids play a crucial role in the membrane-bound form# Belongs to the glycosyltransferase 13 family


uniprot_information_type: SwissProt: Q6IPT4
uniprot_information:
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family &  Contains 1 FAD-binding FR-type domain


uniprot_information_type:
SwissProt: O75553 # The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins# Contains 1 PID domain

uniprot_information:
SwissProt: O75553 # The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins# Contains 1 PID domain


uniprot_information_type:
SwissProt: Q5VVJ2 # Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA# Belongs to the peptidase M67A family. MYSM1 subfamily &  Contains 1 MPN (JAB/Mov34) domain &  Contains 1 SANT domain &  Contains 1 SWIRM domain

uniprot_information:
SwissProt: Q5VVJ2 # Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA# Belongs to the peptidase M67A family. MYSM1 subfamily &  Contains 1 MPN (JAB/Mov34) domain &  Contains 1 SANT domain &  Contains 1 SWIRM domain


uniprot_information_type:
SwissProt: Q96N67 # The DHR-2 domain mediates GEF activity# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain

uniprot_information:
SwissProt: Q96N67 # The DHR-2 domain mediates GEF activity# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain


uniprot_information_type:
SwissProt: P23458 # Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1 &  The FERM domain mediates interaction with JAKMIP1# Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily &  Contains 1 FERM domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain

uniprot_information:
SwissProt: P23458 # Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1 &  The FERM domain mediates interaction with JAKMIP1# Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily &  Contains 1 FERM domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain


uniprot_information_type:
SwissProt: O95218 # The RanBP2-type zinc fingers mediate binding to RNA# Belongs to the ZRANB2 family &  Contains 2 RanBP2-type zinc fingers

uniprot_information:
SwissProt: O95218 # The RanBP2-type zinc fingers mediate binding to RNA# Belongs to the ZRANB2 family &  Contains 2 RanBP2-type zinc fingers


uniprot_information_type: SwissProt: Q7Z3B1
uniprot_information:
Belongs to the immunoglobulin superfamily. IgLON family &  Contains 3 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q8WXJ9 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 1 ANK repeat &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q8WXJ9 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 1 ANK repeat &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q17RW2
uniprot_information:
Belongs to the fibrillar collagen family &  Contains 17 collagen-like domains &  Contains 1 fibrillar collagen NC1 domain &  Contains 1 laminin G-like domain &  Contains 1 TSP N-terminal (TSPN) domain


uniprot_information_type: SwissProt: A2PYH4
uniprot_information:
Belongs to the helicase family. SKI2 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 SEC63 domain


uniprot_information_type: SwissProt: P12107
uniprot_information:
Belongs to the fibrillar collagen family &  Contains 1 fibrillar collagen NC1 domain &  Contains 1 TSP N-terminal (TSPN) domain


uniprot_information_type: SwissProt: Q9UKW4
uniprot_information:
Contains 1 CH (calponin-homology) domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 SH2 domain &  Contains 2 SH3 domains


uniprot_information_type:
SwissProt: Q15543 # The binding of TAF10 and TAF11 requires distinct domains of TAF13# Belongs to the TAF13 family &  Contains 1 histone-fold domain

uniprot_information:
SwissProt: Q15543 # The binding of TAF10 and TAF11 requires distinct domains of TAF13# Belongs to the TAF13 family &  Contains 1 histone-fold domain


uniprot_information_type:
SwissProt: Q99523 # The N-terminal propeptide may facilitate precursor transport within the Golgi stack. Intrachain binding of the N-terminal propeptide and the extracellular domain may also inhibit premature ligand binding &  The extracellular domain may be shed following protease cleavage in some cell types# Belongs to the SORT1 family &  Contains 9 BNR repeats

uniprot_information:
SwissProt: Q99523 # The N-terminal propeptide may facilitate precursor transport within the Golgi stack. Intrachain binding of the N-terminal propeptide and the extracellular domain may also inhibit premature ligand binding &  The extracellular domain may be shed following protease cleavage in some cell types# Belongs to the SORT1 family &  Contains 9 BNR repeats


uniprot_information_type: SwissProt: P21266
uniprot_information:
Belongs to the GST superfamily. Mu family &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain


uniprot_information_type: SwissProt: Q9Y2R2
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type: SwissProt: Q9H8W5
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 filamin repeat &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9UKF2 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: Q9UKF2 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain


uniprot_information_type: SwissProt: P27540
uniprot_information:
Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 2 PAS (PER-ARNT-SIM) domains


uniprot_information_type:
SwissProt: Q9NRR8 # The CRIB domain mediates interaction with CDC42# Belongs to the CDC42SE/SPEC family &  Contains 1 CRIB domain

uniprot_information:
SwissProt: Q9NRR8 # The CRIB domain mediates interaction with CDC42# Belongs to the CDC42SE/SPEC family &  Contains 1 CRIB domain


uniprot_information_type: SwissProt: P51449
uniprot_information:
Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: Q8WXI9 # CR1 is required for interaction with MBD3 and transcription repression &  CR2 is required for localization to discrete loci in the nucleus# Contains 1 GATA-type zinc finger

uniprot_information:
SwissProt: Q8WXI9 # CR1 is required for interaction with MBD3 and transcription repression &  CR2 is required for localization to discrete loci in the nucleus# Contains 1 GATA-type zinc finger


uniprot_information_type:
SwissProt: P06753 # The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity# Belongs to the tropomyosin family

uniprot_information:
SwissProt: P06753 # The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity# Belongs to the tropomyosin family


uniprot_information_type: SwissProt: Q9NR48
uniprot_information:
Belongs to the histone-lysine methyltransferase family. SET2 subfamily &  Contains 3 A.T hook DNA-binding domains &  Contains 1 AWS domain &  Contains 1 BAH domain &  Contains 1 bromo domain &  Contains 1 PHD-type zinc finger &  Contains 1 post-SET domain &  Contains 1 SET domain


uniprot_information_type:
SwissProt: Q92974 # The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA &  The PH (pleckstrin-homology) domain is involved in microtubule binding and targeting to tight junctions# Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger

uniprot_information:
SwissProt: Q92974 # The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA &  The PH (pleckstrin-homology) domain is involved in microtubule binding and targeting to tight junctions# Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger


uniprot_information_type:
SwissProt: A1L020 # Binds RNA through its KH domains (By similarity)# Contains 2 KH domains &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: A1L020 # Binds RNA through its KH domains (By similarity)# Contains 2 KH domains &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q14814 # The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity# Belongs to the MEF2 family &  Contains 1 MADS-box domain &  Contains 1 Mef2-type DNA-binding domain

uniprot_information:
SwissProt: Q14814 # The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity# Belongs to the MEF2 family &  Contains 1 MADS-box domain &  Contains 1 Mef2-type DNA-binding domain


uniprot_information_type:
SwissProt: Q96RD9 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM) (By similarity)# Contains 8 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: Q96RD9 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM) (By similarity)# Contains 8 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q96LA5 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6# Contains 4 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: Q96LA5 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6# Contains 4 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q9P2J2 # The PDZ-binding motif mediates interactions with MAGI2 and SHANK1 (By similarity)# Belongs to the immunoglobulin superfamily. Turtle family &  Contains 2 fibronectin type-III domains &  Contains 5 Ig-like (immunoglobulin-like) domains

uniprot_information:
SwissProt: Q9P2J2 # The PDZ-binding motif mediates interactions with MAGI2 and SHANK1 (By similarity)# Belongs to the immunoglobulin superfamily. Turtle family &  Contains 2 fibronectin type-III domains &  Contains 5 Ig-like (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q969P0 # The Ig-like C2-type domains 3 and 4 are required for interaction with CD81 (By similarity)# Contains 4 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: Q969P0 # The Ig-like C2-type domains 3 and 4 are required for interaction with CD81 (By similarity)# Contains 4 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q9UIB8 # ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A# Contains 1 Ig-like C2-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q9UIB8 # ITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A# Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q13291 # The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues# Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q13291 # The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues# Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: P09326
uniprot_information:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: Q9Y624
uniprot_information:
Belongs to the immunoglobulin superfamily &  Contains 2 Ig-like V-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q96NY8
uniprot_information:
Belongs to the nectin family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: P12259 # Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats# Belongs to the multicopper oxidase family &  Contains 3 F5/8 type A domains &  Contains 2 F5/8 type C domains &  Contains 6 plastocyanin-like domains

uniprot_information:
SwissProt: P12259 # Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats# Belongs to the multicopper oxidase family &  Contains 3 F5/8 type A domains &  Contains 2 F5/8 type C domains &  Contains 6 plastocyanin-like domains


uniprot_information_type:
SwissProt: Q8NHY2 # The RING finger domain, in addition to its role in ubiquitination, functions as a structural scaffold to bring two clusters of positive-charged residues within spatial proximity to mimic a bipartite nuclear localization signal (NLS) (By similarity)# Belongs to the COP1 family &  Contains 1 RING-type zinc finger &  Contains 7 WD repeats

uniprot_information:
SwissProt: Q8NHY2 # The RING finger domain, in addition to its role in ubiquitination, functions as a structural scaffold to bring two clusters of positive-charged residues within spatial proximity to mimic a bipartite nuclear localization signal (NLS) (By similarity)# Belongs to the COP1 family &  Contains 1 RING-type zinc finger &  Contains 7 WD repeats


uniprot_information_type: SwissProt: P42684
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily &  Contains 1 protein kinase domain &  Contains 1 SH2 domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q05823 # The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain &  The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization &  The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is sufficient for ribonuclease activity (By similarity)# Belongs to the protein kinase superfamily &  Contains 9 ANK repeats &  Contains 1 KEN domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q05823 # The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain &  The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization &  The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is sufficient for ribonuclease activity (By similarity)# Belongs to the protein kinase superfamily &  Contains 9 ANK repeats &  Contains 1 KEN domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9BZQ6 # Contains a protease-associated domain (PA) of unknown function# Belongs to the glycosyl hydrolase 47 family &  Contains 1 PA (protease associated) domain

uniprot_information:
SwissProt: Q9BZQ6 # Contains a protease-associated domain (PA) of unknown function# Belongs to the glycosyl hydrolase 47 family &  Contains 1 PA (protease associated) domain


uniprot_information_type: SwissProt: Q6UVM3
uniprot_information:
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.2/KCNT2 sub-subfamily &  Contains 1 RCK N-terminal domain


uniprot_information_type: SwissProt: Q15058
uniprot_information:
Belongs to the kinesin-like protein family &  Contains 1 FHA domain &  Contains 1 kinesin-motor domain


uniprot_information_type:
SwissProt: Q5T1V6 # The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis# Belongs to the DEAD box helicase family. DDX59 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 HIT-type zinc finger

uniprot_information:
SwissProt: Q5T1V6 # The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis# Belongs to the DEAD box helicase family. DDX59 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 HIT-type zinc finger


uniprot_information_type:
SwissProt: Q53G59 # The BTB domain is required for interaction with CUL3# Contains 1 BTB (POZ) domain &  Contains 6 Kelch repeats

uniprot_information:
SwissProt: Q53G59 # The BTB domain is required for interaction with CUL3# Contains 1 BTB (POZ) domain &  Contains 6 Kelch repeats


uniprot_information_type: SwissProt: Q6XUX3
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q5VVQ6 # The UBAX-like region mediates the interaction with VCP. According to PubMed:19818707, it corresponds to a UBX domain, which is a hallmark for VCP-associated proteins. However, no canonical UBX is detected by prediction tools such as Pfam or PROSITE# Contains 1 C2H2-type zinc finger &  Contains 1 OTU domain

uniprot_information:
SwissProt: Q5VVQ6 # The UBAX-like region mediates the interaction with VCP. According to PubMed:19818707, it corresponds to a UBX domain, which is a hallmark for VCP-associated proteins. However, no canonical UBX is detected by prediction tools such as Pfam or PROSITE# Contains 1 C2H2-type zinc finger &  Contains 1 OTU domain


uniprot_information_type:
SwissProt: Q92604 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

uniprot_information:
SwissProt: Q92604 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


uniprot_information_type: SwissProt: Q15678
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily &  Contains 1 FERM domain &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: A6NHC0 # The domain III mediates oligomerization (By similarity)# Belongs to the peptidase C2 family &  Contains 1 calpain catalytic domain &  Contains 3 EF-hand domains

uniprot_information:
SwissProt: A6NHC0 # The domain III mediates oligomerization (By similarity)# Belongs to the peptidase C2 family &  Contains 1 calpain catalytic domain &  Contains 3 EF-hand domains


uniprot_information_type:
SwissProt: Q8N8S7 # The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization# Belongs to the Ena/VASP family &  Contains 1 WH1 domain

uniprot_information:
SwissProt: Q8N8S7 # The EVH2 domain is comprised of 3 regions. Block A is a thymosin-like domain required for G-actin binding. The KLKR motif within this block is essential for the G-actin binding and for actin polymerization. Block B is required for F-actin binding and subcellular location, and Block C for tetramerization# Belongs to the Ena/VASP family &  Contains 1 WH1 domain


uniprot_information_type:
SwissProt: Q96F44 # The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By similarity). They are also involved in MED15-binding &  The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble ubiquitinated proteins (By similarity)# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q96F44 # The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By similarity). They are also involved in MED15-binding &  The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble ubiquitinated proteins (By similarity)# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q9NRK6
uniprot_information:
Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily &  Contains 1 ABC transmembrane type-1 domain &  Contains 1 ABC transporter domain


uniprot_information_type:
SwissProt: Q7Z5L9 # The C-terminal RING-type zinc finger domain is necessary for interaction with BAP1# Belongs to the IRF2BP family

uniprot_information:
SwissProt: Q7Z5L9 # The C-terminal RING-type zinc finger domain is necessary for interaction with BAP1# Belongs to the IRF2BP family


uniprot_information_type:
SwissProt: Q4LE39 # The C-terminus mediates interaction with mSin3A corepressor complex &  The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms &  The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA# Contains 1 ARID domain

uniprot_information:
SwissProt: Q4LE39 # The C-terminus mediates interaction with mSin3A corepressor complex &  The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms &  The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA# Contains 1 ARID domain


uniprot_information_type:
SwissProt: Q12836 # The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida# Belongs to the ZP domain family. ZPB subfamily &  Contains 1 P-type (trefoil) domain &  Contains 1 ZP domain

uniprot_information:
SwissProt: Q12836 # The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida# Belongs to the ZP domain family. ZPB subfamily &  Contains 1 P-type (trefoil) domain &  Contains 1 ZP domain


uniprot_information_type:
SwissProt: Q9Y243 # Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q9Y243 # Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9BS34
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 9 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: Q15973
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 8 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q96IT1 # The C2H2-type zinc finger 1, also named C2HR, mediates the interaction with NSD1 (By similarity)# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain

uniprot_information:
SwissProt: Q96IT1 # The C2H2-type zinc finger 1, also named C2HR, mediates the interaction with NSD1 (By similarity)# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: Q6TDP4
uniprot_information:
Contains 1 BACK (BTB/Kelch associated) domain &  Contains 1 BTB (POZ) domain &  Contains 6 Kelch repeats


uniprot_information_type: SwissProt: Q96AX9
uniprot_information:
Contains 9 ANK repeats &  Contains 2 MIB/HERC2 domains &  Contains 2 RING-type zinc fingers &  Contains 1 ZZ-type zinc finger


uniprot_information_type: SwissProt: O14764
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily


uniprot_information_type:
SwissProt: O15350 # Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL tyrosine kinase SH3 domain &  The WW-binding motif mediates interaction with WWOX# Belongs to the p53 family &  Contains 1 SAM (sterile alpha motif) domain

uniprot_information:
SwissProt: O15350 # Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL tyrosine kinase SH3 domain &  The WW-binding motif mediates interaction with WWOX# Belongs to the p53 family &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: B1AK53 # The WH2-domain binds actin monomer and mediates actin bundle assembly (By similarity)# Contains 9 ANK repeats &  Contains 1 WH2 domain

uniprot_information:
SwissProt: B1AK53 # The WH2-domain binds actin monomer and mediates actin bundle assembly (By similarity)# Contains 9 ANK repeats &  Contains 1 WH2 domain


uniprot_information_type: SwissProt: Q9Y6Y1
uniprot_information:
Belongs to the CAMTA family &  Contains 3 ANK repeats &  Contains 1 CG-1 DNA-binding domain &  Contains 1 IPT/TIG domain &  Contains 3 IQ domains


uniprot_information_type: SwissProt: O95479
uniprot_information:
In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family &  In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily


uniprot_information_type:
SwissProt: Q96BD6 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). The B30.2/SPRY domain is involved in MET binding# Belongs to the SPSB family &  Contains 1 B30.2/SPRY domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q96BD6 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). The B30.2/SPRY domain is involved in MET binding# Belongs to the SPSB family &  Contains 1 B30.2/SPRY domain &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: Q96R05 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

uniprot_information:
SwissProt: Q96R05 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


uniprot_information_type: SwissProt: O60333
uniprot_information:
Belongs to the kinesin-like protein family. Unc-104 subfamily &  Contains 1 FHA domain &  Contains 1 kinesin-motor domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q9NVZ3 # The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity)# Belongs to the NECAP family

uniprot_information:
SwissProt: Q9NVZ3 # The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity)# Belongs to the NECAP family


uniprot_information_type: SwissProt: P29322
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily &  Contains 2 fibronectin type-III domains &  Contains 1 protein kinase domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: Q9NPJ4 # The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif# Belongs to the PNRC family. PNRC2 subfamily

uniprot_information:
SwissProt: Q9NPJ4 # The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif# Belongs to the PNRC family. PNRC2 subfamily


uniprot_information_type:
SwissProt: Q9NZV5 # The N-terminus (first 61 amino acids) contains an endoplasmic reticulum addressing and retention targeting signal# Contains 1 EF-hand domain

uniprot_information:
SwissProt: Q9NZV5 # The N-terminus (first 61 amino acids) contains an endoplasmic reticulum addressing and retention targeting signal# Contains 1 EF-hand domain


uniprot_information_type:
SwissProt: Q07666 # The KH domain is required for binding to RNA (By similarity) &  The Pro-rich domains are flanked by Arg/Gly-rich motifs which can be asymmetric dimethylated on arginine residues to give the DMA/Gly-rich regions. Selective methylation on these motifs can modulate protein-protein interactions (By similarity)# Belongs to the KHDRBS family &  Contains 1 KH domain

uniprot_information:
SwissProt: Q07666 # The KH domain is required for binding to RNA (By similarity) &  The Pro-rich domains are flanked by Arg/Gly-rich motifs which can be asymmetric dimethylated on arginine residues to give the DMA/Gly-rich regions. Selective methylation on these motifs can modulate protein-protein interactions (By similarity)# Belongs to the KHDRBS family &  Contains 1 KH domain


uniprot_information_type: SwissProt: Q9UPN3
uniprot_information:
Belongs to the plakin or cytolinker family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 2 EF-hand domains &  Contains 1 GAR domain &  Contains 1 SH3 domain &  Contains 37 spectrin repeats


uniprot_information_type: Q96PK2
uniprot_information:
Belongs to the plakin or cytolinker family &  Contains 2 EF-hand domains &  Contains 1 GAR domain &  Contains 19 plectin repeats &  Contains 32 spectrin repeats


uniprot_information_type:
SwissProt: P56696 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily

uniprot_information:
SwissProt: P56696 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily


uniprot_information_type: SwissProt: Q7Z5L7
uniprot_information:
Belongs to the small leucine-rich proteoglycan (SLRP) family. Class V subfamily &  Contains 20 LRR (leucine-rich) repeats


uniprot_information_type: SwissProt: P54646
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8NI35 # The L27 domain (also called Maguk recruitment domain) is required for interaction with MPP5 and CRB3, and MPP5 localization to tight junctions &  The PDZ domain 6 mediates interaction with the C-terminus of TJP3 and is crucial for localization to the tight junctions. The PDZ domain 8 interacts with CLDN1 but is not required for proper localization# Contains 1 L27 domain &  Contains 10 PDZ (DHR) domains

uniprot_information:
SwissProt: Q8NI35 # The L27 domain (also called Maguk recruitment domain) is required for interaction with MPP5 and CRB3, and MPP5 localization to tight junctions &  The PDZ domain 6 mediates interaction with the C-terminus of TJP3 and is crucial for localization to the tight junctions. The PDZ domain 8 interacts with CLDN1 but is not required for proper localization# Contains 1 L27 domain &  Contains 10 PDZ (DHR) domains


uniprot_information_type: SwissProt: Q01973
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily &  Contains 1 FZ (frizzled) domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 kringle domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q5VU97
uniprot_information:
Belongs to the calcium channel subunit alpha-2/delta family &  Contains 2 cache domains &  Contains 1 VWFA domain


uniprot_information_type: SwissProt: Q96NW7
uniprot_information:
Belongs to the LAP (LRR and PDZ) protein family &  Contains 18 LRR (leucine-rich) repeats &  Contains 1 PDZ (DHR) domain


uniprot_information_type: SwissProt: P22694
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q03721 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily

uniprot_information:
SwissProt: Q03721 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily


uniprot_information_type: SwissProt: Q96T37
uniprot_information:
Belongs to the RRM Spen family &  Contains 3 RRM (RNA recognition motif) domains &  Contains 1 SPOC domain


uniprot_information_type: SwissProt: Q9UHI6
uniprot_information:
Belongs to the DEAD box helicase family. DDX20 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: Q5TCQ9
uniprot_information:
Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 6 PDZ (DHR) domains &  Contains 2 WW domains


uniprot_information_type:
SwissProt: Q6P589 # The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding# Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily

uniprot_information:
SwissProt: Q6P589 # The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding# Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily


uniprot_information_type:
SwissProt: Q9P2M7 # Deletion of the ZO-1 interaction motif (ZIM) decreases but does not abolish colocalization with ZO-1# Belongs to the cingulin family

uniprot_information:
SwissProt: Q9P2M7 # Deletion of the ZO-1 interaction motif (ZIM) decreases but does not abolish colocalization with ZO-1# Belongs to the cingulin family


uniprot_information_type: SwissProt: P17787
uniprot_information:
Belongs to the ligand-gated ionic channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily


uniprot_information_type: SwissProt: Q7Z4K8
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 COS domain &  Contains 1 fibronectin type-III domain &  Contains 2 RING-type zinc fingers


uniprot_information_type:
SwissProt: Q9P1Z3 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel HCN family &  Contains 1 cyclic nucleotide-binding domain

uniprot_information:
SwissProt: Q9P1Z3 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel HCN family &  Contains 1 cyclic nucleotide-binding domain


uniprot_information_type: SwissProt: Q9H3S1
uniprot_information:
Belongs to the semaphorin family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 PSI domain &  Contains 1 Sema domain


uniprot_information_type: SwissProt: Q96GW7
uniprot_information:
Belongs to the aggrecan/versican proteoglycan family &  Contains 1 C-type lectin domain &  Contains 1 EGF-like domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain &  Contains 2 Link domains &  Contains 1 Sushi (CCP/SCR) domain


uniprot_information_type: SwissProt: Q96J84
uniprot_information:
Belongs to the immunoglobulin superfamily &  Contains 5 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q6K0P9 # The HIN-200 domain mediates interaction with MDM2# Belongs to the HIN-200 family &  Contains 1 DAPIN domain &  Contains 1 HIN-200 domain

uniprot_information:
SwissProt: Q6K0P9 # The HIN-200 domain mediates interaction with MDM2# Belongs to the HIN-200 family &  Contains 1 DAPIN domain &  Contains 1 HIN-200 domain


uniprot_information_type: SwissProt: Q9BVJ7
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type: SwissProt: Q9HBG7
uniprot_information:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 2 Ig-like V-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: P18850 # The basic domain functions as a nuclear localization signal &  The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE# Belongs to the bZIP family. ATF subfamily &  Contains 1 bZIP domain

uniprot_information:
SwissProt: P18850 # The basic domain functions as a nuclear localization signal &  The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE# Belongs to the bZIP family. ATF subfamily &  Contains 1 bZIP domain


uniprot_information_type: SwissProt: Q8TAS1
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 1 protein kinase domain &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type: SwissProt: Q16832
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily &  Contains 1 F5/8 type C domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: P14859
uniprot_information:
Belongs to the POU transcription factor family. Class-2 subfamily &  Contains 1 homeobox DNA-binding domain &  Contains 1 POU-specific domain


uniprot_information_type:
SwissProt: O95297 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the myelin P0 protein family &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: O95297 # Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Belongs to the myelin P0 protein family &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q86X27 # The PH domain mediates binding to phosphatidylinositol 4,5-biphosphate (By similarity)# Contains 1 PH domain &  Contains 1 Ras-GEF domain

uniprot_information:
SwissProt: Q86X27 # The PH domain mediates binding to phosphatidylinositol 4,5-biphosphate (By similarity)# Contains 1 PH domain &  Contains 1 Ras-GEF domain


uniprot_information_type: SwissProt: O00391
uniprot_information:
Belongs to the quiescin-sulfhydryl oxidase (QSOX) family &  Contains 1 ERV/ALR sulfhydryl oxidase domain &  Contains 1 thioredoxin domain


uniprot_information_type:
SwissProt: Q15878 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily &  Contains 1 EF-hand domain

uniprot_information:
SwissProt: Q15878 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily &  Contains 1 EF-hand domain


uniprot_information_type: SwissProt: Q96RW7
uniprot_information:
Contains 7 EGF-like domains &  Contains 44 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 nidogen G2 beta-barrel domain &  Contains 6 TSP type-1 domains &  Contains 1 VWFA domain


uniprot_information_type: SwissProt: P82279
uniprot_information:
Belongs to the Crumbs protein family &  Contains 19 EGF-like domains &  Contains 3 laminin G-like domains


uniprot_information_type:
SwissProt: P51888 # The basic amino-terminal Arg/Pro-rich binds heparin and heparan sulfate. Binds collagens type I and type II through its leucine-rich repeat domain (By similarity)# Belongs to the small leucine-rich proteoglycan (SLRP) family. Class II subfamily &  Contains 12 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: P51888 # The basic amino-terminal Arg/Pro-rich binds heparin and heparan sulfate. Binds collagens type I and type II through its leucine-rich repeat domain (By similarity)# Belongs to the small leucine-rich proteoglycan (SLRP) family. Class II subfamily &  Contains 12 LRR (leucine-rich) repeats


uniprot_information_type: SwissProt: Q9UBM4
uniprot_information:
Belongs to the small leucine-rich proteoglycan (SLRP) family. Class III subfamily &  Contains 7 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: O15151 # Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2# Belongs to the MDM2/MDM4 family &  Contains 1 RanBP2-type zinc finger &  Contains 1 RING-type zinc finger &  Contains 1 SWIB domain

uniprot_information:
SwissProt: O15151 # Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2# Belongs to the MDM2/MDM4 family &  Contains 1 RanBP2-type zinc finger &  Contains 1 RING-type zinc finger &  Contains 1 SWIB domain


uniprot_information_type: SwissProt: O94856
uniprot_information:
Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family &  Contains 5 fibronectin type-III domains &  Contains 6 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q02246
uniprot_information:
Belongs to the immunoglobulin superfamily. Contactin family &  Contains 4 fibronectin type-III domains &  Contains 6 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q8WWW0
uniprot_information:
Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 Ras-associating domain &  Contains 1 SARAH domain


uniprot_information_type: SwissProt: P17927
uniprot_information:
Belongs to the receptors of complement activation (RCA) family &  Contains 30 Sushi (CCP/SCR) domains


uniprot_information_type: SwissProt: Q2VPA4
uniprot_information:
Belongs to the receptors of complement activation (RCA) family &  Contains 8 Sushi (CCP/SCR) domains


uniprot_information_type: SwissProt: Q9Y5Y0
uniprot_information:
Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family


uniprot_information_type: SwissProt: Q9P0L2
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily &  Contains 1 KA1 (kinase-associated) domain &  Contains 1 protein kinase domain &  Contains 1 UBA domain


uniprot_information_type:
SwissProt: Q0VDD8 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family

uniprot_information:
SwissProt: Q0VDD8 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family


uniprot_information_type: SwissProt: Q8NI60
uniprot_information:
Belongs to the protein kinase superfamily. ADCK protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q5VST9
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 DH (DBL-homology) domain &  Contains 3 fibronectin type-III domains &  Contains 55 Ig-like (immunoglobulin-like) domains &  Contains 1 IQ domain &  Contains 2 PH domains &  Contains 2 protein kinase domains &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q10471 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q10471 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type: SwissProt: Q6ZTA4
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 B30.2/SPRY domain &  Contains 1 COS domain &  Contains 1 fibronectin type-III domain &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q5TCX8
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily &  Contains 1 protein kinase domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q99707 # Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin (By similarity)# Belongs to the vitamin-B12 dependent methionine synthase family &  Contains 1 AdoMet activation domain &  Contains 1 B12-binding domain &  Contains 1 B12-binding N-terminal domain &  Contains 1 Hcy-binding domain &  Contains 1 pterin-binding domain

uniprot_information:
SwissProt: Q99707 # Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin (By similarity)# Belongs to the vitamin-B12 dependent methionine synthase family &  Contains 1 AdoMet activation domain &  Contains 1 B12-binding domain &  Contains 1 B12-binding N-terminal domain &  Contains 1 Hcy-binding domain &  Contains 1 pterin-binding domain


uniprot_information_type: SwissProt: Q9NZ56
uniprot_information:
Belongs to the formin homology family. Cappuccino subfamily &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain


uniprot_information_type:
SwissProt: Q9ULH0 # The transmembrane domain mediates interaction with NTRK1 (By similarity)# Contains 12 ANK repeats &  Contains 1 KAP NTPase domain

uniprot_information:
SwissProt: Q9ULH0 # The transmembrane domain mediates interaction with NTRK1 (By similarity)# Contains 12 ANK repeats &  Contains 1 KAP NTPase domain


uniprot_information_type:
SwissProt: Q96SB8 # The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer (By similarity)# Belongs to the SMC family. SMC6 subfamily

uniprot_information:
SwissProt: Q96SB8 # The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer (By similarity)# Belongs to the SMC family. SMC6 subfamily


uniprot_information_type:
SwissProt: Q9Y6K1 # The PWWP domain is essential for targeting to pericentric heterochromatin# Belongs to the C5-methyltransferase family &  Contains 1 ADD-type zinc finger &  Contains 1 PWWP domain

uniprot_information:
SwissProt: Q9Y6K1 # The PWWP domain is essential for targeting to pericentric heterochromatin# Belongs to the C5-methyltransferase family &  Contains 1 ADD-type zinc finger &  Contains 1 PWWP domain


uniprot_information_type:
SwissProt: Q76L83 # Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which may be required for an association with nuclear receptors (By similarity)# Belongs to the Asx family &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: Q76L83 # Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which may be required for an association with nuclear receptors (By similarity)# Belongs to the Asx family &  Contains 1 PHD-type zinc finger


uniprot_information_type: SwissProt: Q6MZZ7
uniprot_information:
Belongs to the peptidase C2 family &  Contains 1 calpain catalytic domain &  Contains 2 EF-hand domains


uniprot_information_type: SwissProt: P47989
uniprot_information:
Belongs to the xanthine dehydrogenase family &  Contains 1 2Fe-2S ferredoxin-type domain &  Contains 1 FAD-binding PCMH-type domain


uniprot_information_type: SwissProt: P19525
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily &  Contains 2 DRBM (double-stranded RNA-binding) domains &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O94806
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily &  Contains 1 PH domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q6P158
uniprot_information:
Belongs to the DEAD box helicase family. DEAH subfamily &  Contains 1 C3H1-type zinc finger &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 UBA domain


uniprot_information_type: SwissProt: Q07889
uniprot_information:
Contains 1 DH (DBL-homology) domain &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 PH domain &  Contains 1 Ras-GEF domain


uniprot_information_type: SwissProt: P32418
uniprot_information:
Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily &  Contains 2 Calx-beta domains


uniprot_information_type:
SwissProt: Q9Y575 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 11 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q9Y575 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 11 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q8TCS8
uniprot_information:
Belongs to the polyribonucleotide nucleotidyltransferase family &  Contains 1 KH domain &  Contains 1 S1 motif domain


uniprot_information_type:
SwissProt: P35612 # Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region# Belongs to the aldolase class II family. Adducin subfamily

uniprot_information:
SwissProt: P35612 # Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region# Belongs to the aldolase class II family. Adducin subfamily


uniprot_information_type:
SwissProt: Q9Y3E7 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components# Belongs to the SNF7 family

uniprot_information:
SwissProt: Q9Y3E7 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components# Belongs to the SNF7 family


uniprot_information_type: SwissProt: Q96K75
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 7 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q6NUI2 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the GPAT/DAPAT family

uniprot_information:
SwissProt: Q6NUI2 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the GPAT/DAPAT family


uniprot_information_type:
SwissProt: O75643 # Composed of two similar domains# Belongs to the helicase family. SKI2 subfamily &  Contains 2 helicase ATP-binding domains &  Contains 2 helicase C-terminal domains &  Contains 2 SEC63 domains

uniprot_information:
SwissProt: O75643 # Composed of two similar domains# Belongs to the helicase family. SKI2 subfamily &  Contains 2 helicase ATP-binding domains &  Contains 2 helicase C-terminal domains &  Contains 2 SEC63 domains


uniprot_information_type:
SwissProt: Q9UBZ9 # The C-terminal domain is necessary for protein interactions# Belongs to the DNA polymerase type-Y family &  Contains 1 BRCT domain &  Contains 1 umuC domain

uniprot_information:
SwissProt: Q9UBZ9 # The C-terminal domain is necessary for protein interactions# Belongs to the DNA polymerase type-Y family &  Contains 1 BRCT domain &  Contains 1 umuC domain


uniprot_information_type:
SwissProt: Q8NC42 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Contains 1 PA (protease associated) domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8NC42 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Contains 1 PA (protease associated) domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: O15259 # The SH3 domain mediates the stable interaction with Cas (By similarity)# Belongs to the nephrocystin-1 family &  Contains 1 SH3 domain

uniprot_information:
SwissProt: O15259 # The SH3 domain mediates the stable interaction with Cas (By similarity)# Belongs to the nephrocystin-1 family &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q8N5P1 # The N-terminal region and all three C3H1-type zinc fingers are necessary to induce transcriptional repression# Contains 3 C3H1-type zinc fingers

uniprot_information:
SwissProt: Q8N5P1 # The N-terminal region and all three C3H1-type zinc fingers are necessary to induce transcriptional repression# Contains 3 C3H1-type zinc fingers


uniprot_information_type: SwissProt: Q9Y2U5
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily &  Contains 1 OPR domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q5FWF4
uniprot_information:
Belongs to the SNF2/RAD54 helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 RanBP2-type zinc finger


uniprot_information_type: SwissProt: O60315
uniprot_information:
Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family &  Contains 7 C2H2-type zinc fingers &  Contains 1 homeobox DNA-binding domain


uniprot_information_type:
SwissProt: O75886 # The VHS and UIM domains mediate the interaction with ubiquitinated proteins &  The SH3 domain mediates the interaction with USP8 &  Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Belongs to the STAM family &  Contains 1 ITAM domain &  Contains 1 SH3 domain &  Contains 1 UIM (ubiquitin-interacting motif) repeat &  Contains 1 VHS domain

uniprot_information:
SwissProt: O75886 # The VHS and UIM domains mediate the interaction with ubiquitinated proteins &  The SH3 domain mediates the interaction with USP8 &  Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Belongs to the STAM family &  Contains 1 ITAM domain &  Contains 1 SH3 domain &  Contains 1 UIM (ubiquitin-interacting motif) repeat &  Contains 1 VHS domain


uniprot_information_type:
SwissProt: O75400 # The WW domains are essential for localization to nuclear speckles (By similarity)# Belongs to the PRPF40 family &  Contains 5 FF domains &  Contains 2 WW domains

uniprot_information:
SwissProt: O75400 # The WW domains are essential for localization to nuclear speckles (By similarity)# Belongs to the PRPF40 family &  Contains 5 FF domains &  Contains 2 WW domains


uniprot_information_type:
SwissProt: Q13018 # C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B &  The endocytosis signal probably mediates endocytosis via clathrin-coated pits (By similarity)# Contains 8 C-type lectin domains &  Contains 1 fibronectin type-II domain &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q13018 # C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B &  The endocytosis signal probably mediates endocytosis via clathrin-coated pits (By similarity)# Contains 8 C-type lectin domains &  Contains 1 fibronectin type-II domain &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: Q9NS40 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily &  Contains 1 cyclic nucleotide-binding domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain

uniprot_information:
SwissProt: Q9NS40 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily &  Contains 1 cyclic nucleotide-binding domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain


uniprot_information_type:
SwissProt: Q15858 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily &  Contains 1 IQ domain

uniprot_information:
SwissProt: Q15858 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily &  Contains 1 IQ domain


uniprot_information_type:
SwissProt: Q01118 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily

uniprot_information:
SwissProt: Q01118 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily


uniprot_information_type: SwissProt: P98164
uniprot_information:
Belongs to the LDLR family &  Contains 17 EGF-like domains &  Contains 36 LDL-receptor class A domains &  Contains 37 LDL-receptor class B repeats


uniprot_information_type:
SwissProt: O43516 # Binds to WAS within the N-terminal region 170, at a site distinct from the CDC42-binding site# Belongs to the verprolin family &  Contains 1 WH2 domain

uniprot_information:
SwissProt: O43516 # Binds to WAS within the N-terminal region 170, at a site distinct from the CDC42-binding site# Belongs to the verprolin family &  Contains 1 WH2 domain


uniprot_information_type:
SwissProt: Q9HCR9 # The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP leading to stimulate the enzyme activity# Belongs to the cyclic nucleotide phosphodiesterase family &  Contains 2 GAF domains

uniprot_information:
SwissProt: Q9HCR9 # The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP leading to stimulate the enzyme activity# Belongs to the cyclic nucleotide phosphodiesterase family &  Contains 2 GAF domains


uniprot_information_type:
SwissProt: Q8WZ42 # ZIS1 and ZIS5 regions contain multiple SPXR consensus sites for ERK- and CDK-like protein kinases as well as multiple SP motifs. ZIS1 could adopt a closed conformation which would block the TCAP-binding site &  The PEVK region may serve as an entropic spring of a chain of structural folds and may also be an interaction site to other myofilament proteins to form interfilament connectivity in the sarcomere# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 132 fibronectin type-III domains &  Contains 152 Ig-like (immunoglobulin-like) domains &  Contains 19 Kelch repeats &  Contains 1 protein kinase domain &  Contains 17 RCC1 repeats &  Contains 14 TPR repeats &  Contains 15 WD repeats

uniprot_information:
SwissProt: Q8WZ42 # ZIS1 and ZIS5 regions contain multiple SPXR consensus sites for ERK- and CDK-like protein kinases as well as multiple SP motifs. ZIS1 could adopt a closed conformation which would block the TCAP-binding site &  The PEVK region may serve as an entropic spring of a chain of structural folds and may also be an interaction site to other myofilament proteins to form interfilament connectivity in the sarcomere# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 132 fibronectin type-III domains &  Contains 152 Ig-like (immunoglobulin-like) domains &  Contains 19 Kelch repeats &  Contains 1 protein kinase domain &  Contains 17 RCC1 repeats &  Contains 14 TPR repeats &  Contains 15 WD repeats


uniprot_information_type:
SwissProt: Q92765 # The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the secreted frizzled-related protein (sFRP) family &  Contains 1 FZ (frizzled) domain &  Contains 1 NTR domain

uniprot_information:
SwissProt: Q92765 # The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the secreted frizzled-related protein (sFRP) family &  Contains 1 FZ (frizzled) domain &  Contains 1 NTR domain


uniprot_information_type:
SwissProt: Q8WXX0 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family

uniprot_information:
SwissProt: Q8WXX0 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family


uniprot_information_type: SwissProt: O94768
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9P2P5
uniprot_information:
Contains 1 C2 domain &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 2 WW domains


uniprot_information_type: SwissProt: Q8N9W6
uniprot_information:
Belongs to the RRM DAZ family &  Contains 1 DAZ-like domain &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type: SwissProt: Q96Q42
uniprot_information:
Contains 1 DH (DBL-homology) domain &  Contains 8 MORN repeats &  Contains 1 PH domain &  Contains 5 RCC1 repeats &  Contains 1 VPS9 domain


uniprot_information_type:
SwissProt: O75840 # The acidic N-terminal part may favor interaction with the basic domain of transcription factors# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 3 C2H2-type zinc fingers

uniprot_information:
SwissProt: O75840 # The acidic N-terminal part may favor interaction with the basic domain of transcription factors# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 3 C2H2-type zinc fingers


uniprot_information_type: SwissProt: Q15303
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9P2E8 # The RING-CH-type zinc finger domain is required for E3 ligase activity# Contains 1 RING-CH-type zinc finger

uniprot_information:
SwissProt: Q9P2E8 # The RING-CH-type zinc finger domain is required for E3 ligase activity# Contains 1 RING-CH-type zinc finger


uniprot_information_type: SwissProt: Q6PIS1
uniprot_information:
Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily


uniprot_information_type:
SwissProt: P54764 # The protein kinase domain mediates interaction with NGEF/ephexin-1 (By similarity)# Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily &  Contains 2 fibronectin type-III domains &  Contains 1 protein kinase domain &  Contains 1 SAM (sterile alpha motif) domain

uniprot_information:
SwissProt: P54764 # The protein kinase domain mediates interaction with NGEF/ephexin-1 (By similarity)# Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily &  Contains 2 fibronectin type-III domains &  Contains 1 protein kinase domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type: SwissProt: P23760
uniprot_information:
Belongs to the paired homeobox family &  Contains 1 homeobox DNA-binding domain &  Contains 1 paired domain


uniprot_information_type: SwissProt: Q9NSD9
uniprot_information:
Belongs to the phenylalanyl-tRNA synthetase beta chain family. Type 2 subfamily &  Contains 1 B5 domain


uniprot_information_type:
SwissProt: P53420 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain

uniprot_information:
SwissProt: P53420 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain


uniprot_information_type:
SwissProt: Q2M3C7 # RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer (By similarity)# Belongs to the AKAP110 family

uniprot_information:
SwissProt: Q2M3C7 # RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer (By similarity)# Belongs to the AKAP110 family


uniprot_information_type: SwissProt: Q9HB58
uniprot_information:
Contains 1 bromo domain &  Contains 1 HSR domain &  Contains 1 PHD-type zinc finger &  Contains 1 SAND domain


uniprot_information_type:
SwissProt: Q8N5V2 # The DH domain and the PH domain are both required to mediate interaction with EPHA4 (By similarity)# Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q8N5V2 # The DH domain and the PH domain are both required to mediate interaction with EPHA4 (By similarity)# Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q96HZ4 # The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity) &  Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain

uniprot_information:
SwissProt: Q96HZ4 # The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity) &  Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain


uniprot_information_type:
SwissProt: P56524 # The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm# Belongs to the histone deacetylase family. Type 2 subfamily

uniprot_information:
SwissProt: P56524 # The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm# Belongs to the histone deacetylase family. Type 2 subfamily


uniprot_information_type: SwissProt: Q9UKF6
uniprot_information:
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF3 subfamily


uniprot_information_type:
SwissProt: Q6P1J6 # Repeat 2 contains the catalytic domain (By similarity)# Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily

uniprot_information:
SwissProt: Q6P1J6 # Repeat 2 contains the catalytic domain (By similarity)# Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily


uniprot_information_type:
SwissProt: Q5MJ70 # The C-terminus is required for CDK2-activation, but not CDK2-binding (By similarity)# Belongs to the Speedy/Ringo family

uniprot_information:
SwissProt: Q5MJ70 # The C-terminus is required for CDK2-activation, but not CDK2-binding (By similarity)# Belongs to the Speedy/Ringo family


uniprot_information_type:
SwissProt: Q6UWP7 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

uniprot_information:
SwissProt: Q6UWP7 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


uniprot_information_type:
SwissProt: Q9NZN3 # The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity)# Contains 1 EF-hand domain &  Contains 1 EH domain

uniprot_information:
SwissProt: Q9NZN3 # The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity)# Contains 1 EF-hand domain &  Contains 1 EH domain


uniprot_information_type: SwissProt: Q9NR09
uniprot_information:
In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family &  Contains 1 BIR repeat


uniprot_information_type: SwissProt: Q8IV61
uniprot_information:
Belongs to the RASGRP family &  Contains 2 EF-hand domains &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 Ras-GEF domain


uniprot_information_type: SwissProt: Q9BTC8
uniprot_information:
Contains 1 BAH domain &  Contains 1 ELM2 domain &  Contains 1 GATA-type zinc finger &  Contains 1 SANT domain


uniprot_information_type: SwissProt: Q9H221
uniprot_information:
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily &  Contains 1 ABC transmembrane type-2 domain &  Contains 1 ABC transporter domain


uniprot_information_type:
SwissProt: Q02156 # The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q02156 # The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q01082
uniprot_information:
Belongs to the spectrin family &  Contains 2 CH (calponin-homology) domains &  Contains 1 PH domain &  Contains 17 spectrin repeats


uniprot_information_type: SwissProt: P62979
uniprot_information:
In the N-terminal section; belongs to the ubiquitin family &  In the C-terminal section; belongs to the ribosomal protein S27Ae family &  Contains 1 ubiquitin-like domain


uniprot_information_type:
SwissProt: Q6ULP2 # The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity)#

uniprot_information:
SwissProt: Q6ULP2 # The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity)#


uniprot_information_type:
SwissProt: Q8IW19 # The PBZ-type zinc fingers (also named CYR) mediate non-covalent poly(ADP-ribose)-binding. Poly(ADP-ribose)-binding is dependent on the presence of zinc and promotes its recruitment to DNA damage sites &  The FHA-like domain mediates interaction with XRCC1 and XRCC4# Belongs to the APLF family &  Contains 1 FHA-like domain &  Contains 2 PBZ-type zinc fingers

uniprot_information:
SwissProt: Q8IW19 # The PBZ-type zinc fingers (also named CYR) mediate non-covalent poly(ADP-ribose)-binding. Poly(ADP-ribose)-binding is dependent on the presence of zinc and promotes its recruitment to DNA damage sites &  The FHA-like domain mediates interaction with XRCC1 and XRCC4# Belongs to the APLF family &  Contains 1 FHA-like domain &  Contains 2 PBZ-type zinc fingers


uniprot_information_type:
SwissProt: Q9H6X2 # Binding to PA seems to be effected through the VWA domain# Belongs to the ATR family &  Contains 1 VWFA domain

uniprot_information:
SwissProt: Q9H6X2 # Binding to PA seems to be effected through the VWA domain# Belongs to the ATR family &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: O95630 # The JAMM motif is essential for the protease activity (By similarity)# Belongs to the peptidase M67C family &  Contains 1 MPN (JAB/Mov34) domain

uniprot_information:
SwissProt: O95630 # The JAMM motif is essential for the protease activity (By similarity)# Belongs to the peptidase M67C family &  Contains 1 MPN (JAB/Mov34) domain


uniprot_information_type:
SwissProt: Q9C0G6 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family

uniprot_information:
SwissProt: Q9C0G6 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family


uniprot_information_type:
SwissProt: Q9Y4C1 # The JmjC domain and the C6-type zinc-finger are required for the demethylation activity &  Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity)# Belongs to the JHDM2 histone demethylase family &  Contains 1 JmjC domain

uniprot_information:
SwissProt: Q9Y4C1 # The JmjC domain and the C6-type zinc-finger are required for the demethylation activity &  Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity)# Belongs to the JHDM2 histone demethylase family &  Contains 1 JmjC domain


uniprot_information_type: SwissProt: O95819
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 CNH domain &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q01638
uniprot_information:
Belongs to the interleukin-1 receptor family &  Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 TIR domain


uniprot_information_type:
SwissProt: P49792 # Contains F-X-F-G repeats# Contains 1 PPIase cyclophilin-type domain &  Contains 4 RanBD1 domains &  Contains 8 RanBP2-type zinc fingers &  Contains 1 TPR repeat

uniprot_information:
SwissProt: P49792 # Contains F-X-F-G repeats# Contains 1 PPIase cyclophilin-type domain &  Contains 4 RanBD1 domains &  Contains 8 RanBP2-type zinc fingers &  Contains 1 TPR repeat


uniprot_information_type:
SwissProt: Q8TEJ3 # The third SH3 domain mediates interaction with PAK2# Belongs to the SH3RF family &  Contains 1 RING-type zinc finger &  Contains 4 SH3 domains

uniprot_information:
SwissProt: Q8TEJ3 # The third SH3 domain mediates interaction with PAK2# Belongs to the SH3RF family &  Contains 1 RING-type zinc finger &  Contains 4 SH3 domains


uniprot_information_type:
SwissProt: O43521 # The BH3 motif is required for Bcl-2 binding and cytotoxicity# Belongs to the Bcl-2 family

uniprot_information:
SwissProt: O43521 # The BH3 motif is required for Bcl-2 binding and cytotoxicity# Belongs to the Bcl-2 family


uniprot_information_type: SwissProt: P29074
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily &  Contains 1 FERM domain &  Contains 1 PDZ (DHR) domain &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type: SwissProt: Q6PIF6
uniprot_information:
Contains 2 FERM domains &  Contains 6 IQ domains &  Contains 1 myosin head-like domain &  Contains 3 MyTH4 domains &  Contains 2 SH3 domains


uniprot_information_type:
SwissProt: Q9NYU2 # The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects (By similarity)# Belongs to the glycosyltransferase 8 family

uniprot_information:
SwissProt: Q9NYU2 # The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects (By similarity)# Belongs to the glycosyltransferase 8 family


uniprot_information_type: SwissProt: P27037
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q96PY5
uniprot_information:
Belongs to the formin homology family &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


uniprot_information_type:
SwissProt: Q8IUC8 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q8IUC8 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type: SwissProt: P43304
uniprot_information:
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family &  Contains 2 EF-hand domains


uniprot_information_type:
SwissProt: Q7Z7M9 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q7Z7M9 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: Q99250 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily &  Contains 1 IQ domain

uniprot_information:
SwissProt: Q99250 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.2/SCN2A subfamily &  Contains 1 IQ domain


uniprot_information_type:
SwissProt: Q8IVI9 # The SH3 domain mediates interaction with NOS3, DNM2 and WASL &  The FCH domain is necessary for membrane targeting# Contains 1 FCH domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q8IVI9 # The SH3 domain mediates interaction with NOS3, DNM2 and WASL &  The FCH domain is necessary for membrane targeting# Contains 1 FCH domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: Q9NYL2
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily &  Contains 1 protein kinase domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type: SwissProt: O00116
uniprot_information:
Belongs to the FAD-binding oxidoreductase/transferase type 4 family &  Contains 1 FAD-binding PCMH-type domain


uniprot_information_type: SwissProt: Q15111
uniprot_information:
Contains 1 C2 domain &  Contains 1 PH domain &  Contains 1 PI-PLC X-box domain &  Contains 1 PI-PLC Y-box domain


uniprot_information_type:
SwissProt: O15519 # The caspase domain lacks the active sites residues involved in catalysis# Belongs to the peptidase C14A family &  Contains 2 DED (death effector) domains

uniprot_information:
SwissProt: O15519 # The caspase domain lacks the active sites residues involved in catalysis# Belongs to the peptidase C14A family &  Contains 2 DED (death effector) domains


uniprot_information_type:
SwissProt: Q9C0K7 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q9C0K7 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q96Q40
uniprot_information:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9NYB9
uniprot_information:
Belongs to the ABI family &  Contains 1 SH3 domain &  Contains 1 t-SNARE coiled-coil homology domain


uniprot_information_type:
SwissProt: Q8TEW8 # The N-terminal part (1-351) part blocks the association of the tight junction marker TJP1 with the cell-cell boundary when it is overexpressed# Belongs to the PAR3 family &  Contains 3 PDZ (DHR) domains

uniprot_information:
SwissProt: Q8TEW8 # The N-terminal part (1-351) part blocks the association of the tight junction marker TJP1 with the cell-cell boundary when it is overexpressed# Belongs to the PAR3 family &  Contains 3 PDZ (DHR) domains


uniprot_information_type: SwissProt: O60462
uniprot_information:
Belongs to the neuropilin family &  Contains 2 CUB domains &  Contains 2 F5/8 type C domains &  Contains 1 MAM domain


uniprot_information_type:
SwissProt: O75077 # A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: O75077 # A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain


uniprot_information_type:
SwissProt: Q9BRC7 # The PDZ-binding motif mediates the interaction with GRIP1 &  The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes &  The PH domain is not a critical determinant of the membrane localization# Contains 1 C2 domain &  Contains 3 EF-hand domains &  Contains 1 PH domain &  Contains 1 PI-PLC X-box domain &  Contains 1 PI-PLC Y-box domain

uniprot_information:
SwissProt: Q9BRC7 # The PDZ-binding motif mediates the interaction with GRIP1 &  The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes &  The PH domain is not a critical determinant of the membrane localization# Contains 1 C2 domain &  Contains 3 EF-hand domains &  Contains 1 PH domain &  Contains 1 PI-PLC X-box domain &  Contains 1 PI-PLC Y-box domain


uniprot_information_type: SwissProt: Q15772
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 2 fibronectin type-III domains &  Contains 9 Ig-like (immunoglobulin-like) domains &  Contains 2 protein kinase domains


uniprot_information_type:
SwissProt: P52594 # Contains FG repeats. The FG repeat region is required for acting as a cofactor of HIV-1 Rev# Contains 1 Arf-GAP domain

uniprot_information:
SwissProt: P52594 # Contains FG repeats. The FG repeat region is required for acting as a cofactor of HIV-1 Rev# Contains 1 Arf-GAP domain


uniprot_information_type:
SwissProt: Q92835 # The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for tyrosine phosphorylation (By similarity) &  The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain (By similarity)# Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family &  Contains 1 SH2 domain

uniprot_information:
SwissProt: Q92835 # The SH2 domain interacts with tyrosine phosphorylated forms of proteins such as SHC1 or PTPN11/SHP-2. It competes with that of GRB2 for binding to phosphorylated SHC1 to inhibit the Ras pathway. It is also required for tyrosine phosphorylation (By similarity) &  The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain (By similarity)# Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family &  Contains 1 SH2 domain


uniprot_information_type:
SwissProt: Q9UPQ3 # The PH domain mediates AP-3 binding# Belongs to the centaurin gamma-like family &  Contains 2 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q9UPQ3 # The PH domain mediates AP-3 binding# Belongs to the centaurin gamma-like family &  Contains 2 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q9Y576 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q9Y576 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q9NS91
uniprot_information:
Belongs to the RAD18 family &  Contains 1 Rad18-type zinc finger &  Contains 1 RING-type zinc finger &  Contains 1 SAP domain


uniprot_information_type:
SwissProt: Q8N4Q1 # The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria (Probable)# Contains 1 CHCH domain

uniprot_information:
SwissProt: Q8N4Q1 # The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria (Probable)# Contains 1 CHCH domain


uniprot_information_type: SwissProt: Q9H1K0
uniprot_information:
Contains 1 C2H2-type zinc finger &  Contains 1 FYVE-type zinc finger &  Contains 1 UIM (ubiquitin-interacting motif) repeat


uniprot_information_type:
SwissProt: Q9NYS0 # In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins# Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily

uniprot_information:
SwissProt: Q9NYS0 # In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins# Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily


uniprot_information_type:
SwissProt: P10828 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P10828 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR1 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type: SwissProt: Q6ZWH5
uniprot_information:
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily &  Contains 1 ARM repeat &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9C098
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9UI33 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily

uniprot_information:
SwissProt: Q9UI33 # The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position# Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily


uniprot_information_type:
SwissProt: Q96C45 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily &  Contains 5 HEAT repeats &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q96C45 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily &  Contains 5 HEAT repeats &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: P59923
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 14 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type:
SwissProt: Q9NYG2 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q9NYG2 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: Q8N114 # The proline-rich region is required for endoplasmic reticulum localization# Belongs to the shisa family

uniprot_information:
SwissProt: Q8N114 # The proline-rich region is required for endoplasmic reticulum localization# Belongs to the shisa family


uniprot_information_type: SwissProt: P13861
uniprot_information:
Belongs to the cAMP-dependent kinase regulatory chain family &  Contains 2 cyclic nucleotide-binding domains


uniprot_information_type:
SwissProt: P61586 # The basic-rich region is essential for yopT recognition and cleavage# Belongs to the small GTPase superfamily. Rho family

uniprot_information:
SwissProt: P61586 # The basic-rich region is essential for yopT recognition and cleavage# Belongs to the small GTPase superfamily. Rho family


uniprot_information_type:
SwissProt: Q9Y4B6 # The DWD boxes are required for interaction with DDB1# Belongs to the VPRBP/DCAF1 family &  Contains 1 LisH domain &  Contains 5 WD repeats

uniprot_information:
SwissProt: Q9Y4B6 # The DWD boxes are required for interaction with DDB1# Belongs to the VPRBP/DCAF1 family &  Contains 1 LisH domain &  Contains 5 WD repeats


uniprot_information_type:
SwissProt: Q6ZR08 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family

uniprot_information:
SwissProt: Q6ZR08 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family


uniprot_information_type:
SwissProt: Q9ULU8 # The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It however does not mediate binding to DCVs (By similarity)# Contains 1 C2 domain &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q9ULU8 # The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It however does not mediate binding to DCVs (By similarity)# Contains 1 C2 domain &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 PH domain


uniprot_information_type: SwissProt: Q7Z3G6
uniprot_information:
Belongs to the prickle / espinas / testin family &  Contains 3 LIM zinc-binding domains &  Contains 1 PET domain


uniprot_information_type:
SwissProt: Q9P2N4 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix (By similarity) &  The ancillary domains, including the TSRs domain, are required for specific extracellular localization and for its versicanase and aggrecanase activities &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 GON domain &  Contains 1 peptidase M12B domain &  Contains 15 TSP type-1 domains

uniprot_information:
SwissProt: Q9P2N4 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix (By similarity) &  The ancillary domains, including the TSRs domain, are required for specific extracellular localization and for its versicanase and aggrecanase activities &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 GON domain &  Contains 1 peptidase M12B domain &  Contains 15 TSP type-1 domains


uniprot_information_type:
SwissProt: Q96JA1 # The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted# Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 17 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q96JA1 # The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted# Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 17 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: P82094 # The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]#

uniprot_information:
SwissProt: P82094 # The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV]#


uniprot_information_type:
SwissProt: Q9H334 # The leucine-zipper is required for dimerization and transcriptional repression (By similarity)# Contains 1 C2H2-type zinc finger &  Contains 1 fork-head DNA-binding domain

uniprot_information:
SwissProt: Q9H334 # The leucine-zipper is required for dimerization and transcriptional repression (By similarity)# Contains 1 C2H2-type zinc finger &  Contains 1 fork-head DNA-binding domain


uniprot_information_type: SwissProt: Q9BY31
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 22 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: A8MPY1
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR3 sub-subfamily


uniprot_information_type:
SwissProt: Q13191 # The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain &  The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme &  The UBA domain interacts with poly-ubiquitinated proteins# Contains 1 CBL N-terminal domain &  Contains 2 EF-hand-like domains &  Contains 1 RING-type zinc finger &  Contains 1 SH2 domain &  Contains 1 UBA domain

uniprot_information:
SwissProt: Q13191 # The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain &  The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme &  The UBA domain interacts with poly-ubiquitinated proteins# Contains 1 CBL N-terminal domain &  Contains 2 EF-hand-like domains &  Contains 1 RING-type zinc finger &  Contains 1 SH2 domain &  Contains 1 UBA domain


uniprot_information_type:
SwissProt: Q9NWB7 # The pseudo DED region (pDED) meadiates the interaction with HIP1# Belongs to the IFT57 family

uniprot_information:
SwissProt: Q9NWB7 # The pseudo DED region (pDED) meadiates the interaction with HIP1# Belongs to the IFT57 family


uniprot_information_type: SwissProt: P49841
uniprot_information:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q86SU0
uniprot_information:
Belongs to the immunoglobulin superfamily. LISCH7 family &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: O95622
uniprot_information:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family &  Contains 2 guanylate cyclase domains


uniprot_information_type: SwissProt: Q15746
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 fibronectin type-III domain &  Contains 9 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9HAT0 # The RIIa domain mediates interaction with AKAP3 (By similarity)# Belongs to the ropporin family &  Contains 1 RIIa domain

uniprot_information:
SwissProt: Q9HAT0 # The RIIa domain mediates interaction with AKAP3 (By similarity)# Belongs to the ropporin family &  Contains 1 RIIa domain


uniprot_information_type:
SwissProt: P50120 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

uniprot_information:
SwissProt: P50120 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


uniprot_information_type: SwissProt: P00450
uniprot_information:
Belongs to the multicopper oxidase family &  Contains 3 F5/8 type A domains &  Contains 6 plastocyanin-like domains


uniprot_information_type: SwissProt: Q6WRI0
uniprot_information:
Contains 12 Ig-like C2-type (immunoglobulin-like) domains &  Contains 13 LRR (leucine-rich) repeats &  Contains 1 LRRNT domain


uniprot_information_type: SwissProt: Q9H2U1
uniprot_information:
Belongs to the DEAD box helicase family. DEAH subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q14D04 # The PH domain is required for membrane targeting (By similarity)# Belongs to the MELT/VEPH family &  Contains 1 PH domain

uniprot_information:
SwissProt: Q14D04 # The PH domain is required for membrane targeting (By similarity)# Belongs to the MELT/VEPH family &  Contains 1 PH domain


uniprot_information_type: SwissProt: Q8IWR1
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: O00629 # Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import &  The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity) &  The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)# Belongs to the importin alpha family &  Contains 10 ARM repeats &  Contains 1 IBB domain

uniprot_information:
SwissProt: O00629 # Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import &  The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity) &  The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)# Belongs to the importin alpha family &  Contains 10 ARM repeats &  Contains 1 IBB domain


uniprot_information_type:
SwissProt: Q03112 # Both zinc finger regions are required for the transcriptional activation of PBX1# Contains 10 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q03112 # Both zinc finger regions are required for the transcriptional activation of PBX1# Contains 10 C2H2-type zinc fingers


uniprot_information_type: SwissProt: Q8TBB6
uniprot_information:
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family


uniprot_information_type: SwissProt: Q13393
uniprot_information:
Belongs to the phospholipase D family &  Contains 1 PH domain &  Contains 2 PLD phosphodiesterase domains &  Contains 1 PX (phox homology) domain


uniprot_information_type:
SwissProt: Q9BZK7 # The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes (By similarity)# Belongs to the WD repeat EBI family &  Contains 1 F-box-like domain &  Contains 1 LisH domain &  Contains 8 WD repeats

uniprot_information:
SwissProt: Q9BZK7 # The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes (By similarity)# Belongs to the WD repeat EBI family &  Contains 1 F-box-like domain &  Contains 1 LisH domain &  Contains 8 WD repeats


uniprot_information_type: SwissProt: O15440
uniprot_information:
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily &  Contains 2 ABC transmembrane type-1 domains &  Contains 2 ABC transporter domains


uniprot_information_type:
SwissProt: Q9Y6M1 # The third and fourth KH domains are important for binding to the untranslated region (UTR) of target mRNA# Belongs to the RRM IMP/VICKZ family &  Contains 4 KH domains &  Contains 2 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: Q9Y6M1 # The third and fourth KH domains are important for binding to the untranslated region (UTR) of target mRNA# Belongs to the RRM IMP/VICKZ family &  Contains 4 KH domains &  Contains 2 RRM (RNA recognition motif) domains


uniprot_information_type: SwissProt: P49619
uniprot_information:
Belongs to the eukaryotic diacylglycerol kinase family &  Contains 1 DAGKc domain &  Contains 2 EF-hand domains &  Contains 2 phorbol-ester/DAG-type zinc fingers


uniprot_information_type:
SwissProt: P22914 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains

uniprot_information:
SwissProt: P22914 # Has a two-domain beta-structure, folded into four very similar Greek key motifs# Belongs to the beta/gamma-crystallin family &  Contains 4 beta/gamma crystallin 'Greek key' domains


uniprot_information_type: SwissProt: P48740
uniprot_information:
Belongs to the peptidase S1 family &  Contains 2 CUB domains &  Contains 1 EGF-like domain &  Contains 1 peptidase S1 domain &  Contains 2 Sushi (CCP/SCR) domains


uniprot_information_type:
SwissProt: Q9H089 # In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern# Belongs to the MMR1/HSR1 GTP-binding protein family. LSG1 subfamily

uniprot_information:
SwissProt: Q9H089 # In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern# Belongs to the MMR1/HSR1 GTP-binding protein family. LSG1 subfamily


uniprot_information_type:
SwissProt: Q8WVZ1 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q8WVZ1 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: Q8IYW5 # The MIU motifs (motif interacting with ubiquitin) mediate the interaction with ubiquitin and the localization at sites of DNA damage# Belongs to the RNF168 family &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8IYW5 # The MIU motifs (motif interacting with ubiquitin) mediate the interaction with ubiquitin and the localization at sites of DNA damage# Belongs to the RNF168 family &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q6UXK5
uniprot_information:
Contains 1 fibronectin type-III domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 11 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: O43187 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily &  Contains 1 death domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: O43187 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily &  Contains 1 death domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O95352 # The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12 (By similarity)# Belongs to the ATG7 family

uniprot_information:
SwissProt: O95352 # The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12 (By similarity)# Belongs to the ATG7 family


uniprot_information_type: SwissProt: P49116
uniprot_information:
Belongs to the nuclear hormone receptor family. NR2 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: Q8N3T1 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q8N3T1 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: Q9UPV9 # The C-terminal region is required for the early endosomal and mitochondrial localization# Contains 1 HAP1 N-terminal domain

uniprot_information:
SwissProt: Q9UPV9 # The C-terminal region is required for the early endosomal and mitochondrial localization# Contains 1 HAP1 N-terminal domain


uniprot_information_type: SwissProt: Q9P0L1
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 13 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: O14709
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 22 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: Q9H3S7
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily &  Contains 1 BRO1 domain &  Contains 2 TPR repeats &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type: SwissProt: Q7L2E3
uniprot_information:
Belongs to the DEAD box helicase family. DEAH subfamily &  Contains 1 DRBM (double-stranded RNA-binding) domain &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: P52756
uniprot_information:
Belongs to the RBM5/RBM10 family &  Contains 1 C2H2-type zinc finger &  Contains 1 G-patch domain &  Contains 1 RanBP2-type zinc finger &  Contains 2 RRM (RNA recognition motif) domains


uniprot_information_type:
SwissProt: Q9P2D7 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family &  Contains 19 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q9P2D7 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family &  Contains 19 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q9UKG1 # Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect# Contains 1 PH domain &  Contains 1 PID domain

uniprot_information:
SwissProt: Q9UKG1 # Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect# Contains 1 PH domain &  Contains 1 PID domain


uniprot_information_type:
SwissProt: Q7Z7A4 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily &  Contains 1 protein kinase domain &  Contains 1 PX (phox homology) domain &  Contains 1 WH2 domain

uniprot_information:
SwissProt: Q7Z7A4 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily &  Contains 1 protein kinase domain &  Contains 1 PX (phox homology) domain &  Contains 1 WH2 domain


uniprot_information_type: SwissProt: P23470
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily &  Contains 1 alpha-carbonic anhydrase domain &  Contains 1 fibronectin type-III domain &  Contains 2 tyrosine-protein phosphatase domains


uniprot_information_type: SwissProt: Q8NFY9
uniprot_information:
Contains 1 BACK (BTB/Kelch associated) domain &  Contains 1 BTB (POZ) domain &  Contains 5 Kelch repeats


uniprot_information_type: SwissProt: Q9HCK4
uniprot_information:
Belongs to the immunoglobulin superfamily. ROBO family &  Contains 3 fibronectin type-III domains &  Contains 5 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q8IYP9 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q8IYP9 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: Q495A1 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q495A1 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: Q9Y2K9
uniprot_information:
Belongs to the WD repeat L(2)GL family &  Contains 1 v-SNARE coiled-coil homology domain &  Contains 14 WD repeats


uniprot_information_type:
SwissProt: O60229 # The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 CRAL-TRIO domain &  Contains 2 DH (DBL-homology) domains &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 2 PH domains &  Contains 1 protein kinase domain &  Contains 2 SH3 domains &  Contains 5 spectrin repeats

uniprot_information:
SwissProt: O60229 # The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family &  Contains 1 CRAL-TRIO domain &  Contains 2 DH (DBL-homology) domains &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 2 PH domains &  Contains 1 protein kinase domain &  Contains 2 SH3 domains &  Contains 5 spectrin repeats


uniprot_information_type: SwissProt: Q3ZCT8
uniprot_information:
Contains 1 BACK (BTB/Kelch associated) domain &  Contains 1 BTB (POZ) domain &  Contains 4 Kelch repeats


uniprot_information_type:
SwissProt: Q96A44 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the SPSB family &  Contains 1 B30.2/SPRY domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q96A44 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the SPSB family &  Contains 1 B30.2/SPRY domain &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q15283
uniprot_information:
Contains 1 Btk-type zinc finger &  Contains 2 C2 domains &  Contains 1 PH domain &  Contains 1 Ras-GAP domain


uniprot_information_type:
SwissProt: Q9UBF6 # The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion# Belongs to the RING-box family &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q9UBF6 # The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion# Belongs to the RING-box family &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: P61225 # The effector domain mediates the interaction with RUNDC3A (By similarity)# Belongs to the small GTPase superfamily. Ras family

uniprot_information:
SwissProt: P61225 # The effector domain mediates the interaction with RUNDC3A (By similarity)# Belongs to the small GTPase superfamily. Ras family


uniprot_information_type: SwissProt: Q9NPC7
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 8 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q9Y691 # The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus# Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily

uniprot_information:
SwissProt: Q9Y691 # The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus# Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily


uniprot_information_type: SwissProt: O60344
uniprot_information:
In the N-terminal section; belongs to the methyltransferase superfamily &  In the C-terminal section; belongs to the peptidase M13 family


uniprot_information_type:
SwissProt: Q9HC62 # The N-terminus is necessary and sufficient for nuclear envelope targeting# Belongs to the peptidase C48 family

uniprot_information:
SwissProt: Q9HC62 # The N-terminus is necessary and sufficient for nuclear envelope targeting# Belongs to the peptidase C48 family


uniprot_information_type:
SwissProt: P52824 # The L-X-X-L-L repeats are implicated in binding to the nuclear receptor NR5A1# Belongs to the eukaryotic diacylglycerol kinase family &  Contains 1 DAGKc domain &  Contains 3 phorbol-ester/DAG-type zinc fingers &  Contains 1 Ras-associating domain

uniprot_information:
SwissProt: P52824 # The L-X-X-L-L repeats are implicated in binding to the nuclear receptor NR5A1# Belongs to the eukaryotic diacylglycerol kinase family &  Contains 1 DAGKc domain &  Contains 3 phorbol-ester/DAG-type zinc fingers &  Contains 1 Ras-associating domain


uniprot_information_type:
SwissProt: Q9HCC9 # The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not monoubiquitinated at Lys-87# Belongs to the lst-2 family &  Contains 1 FYVE-type zinc finger

uniprot_information:
SwissProt: Q9HCC9 # The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not monoubiquitinated at Lys-87# Belongs to the lst-2 family &  Contains 1 FYVE-type zinc finger


uniprot_information_type:
SwissProt: Q6PIL6 # The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4 current to a slowly inactivating delayed rectifier potassium current (By similarity)# Belongs to the recoverin family &  Contains 4 EF-hand domains

uniprot_information:
SwissProt: Q6PIL6 # The KIS (K-channel inactivation suppressor) domain is required for converting A-type Kv4 current to a slowly inactivating delayed rectifier potassium current (By similarity)# Belongs to the recoverin family &  Contains 4 EF-hand domains


uniprot_information_type: SwissProt: Q9BXR5
uniprot_information:
Belongs to the Toll-like receptor family &  Contains 15 LRR (leucine-rich) repeats &  Contains 1 TIR domain


uniprot_information_type: SwissProt: Q8N1C3
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG1 sub-subfamily


uniprot_information_type: SwissProt: P48169
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA4 sub-subfamily


uniprot_information_type: SwissProt: Q6ZNB6
uniprot_information:
Belongs to the NFX1 family &  Contains 10 NF-X1-type zinc fingers &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q8TBB1 # The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient &  The PDZ 1 domain participates in the interaction with the PID domain of NUMB, and participates in the isoform-specific ubiquitination of NUMB. The PDZ 2 domain of isoform 2 participates in the interaction with IGSF5/JAM4, other isoforms containing this domain may also interact with IGSF5/JAM4 (By similarity)# Contains 4 PDZ (DHR) domains &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8TBB1 # The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient &  The PDZ 1 domain participates in the interaction with the PID domain of NUMB, and participates in the isoform-specific ubiquitination of NUMB. The PDZ 2 domain of isoform 2 participates in the interaction with IGSF5/JAM4, other isoforms containing this domain may also interact with IGSF5/JAM4 (By similarity)# Contains 4 PDZ (DHR) domains &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q96PM5
uniprot_information:
Contains 1 CHY-type zinc finger &  Contains 1 CTCHY-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q92772 # The [NKR]KIAxRE motif seems to be a cyclin-binding region# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q92772 # The [NKR]KIAxRE motif seems to be a cyclin-binding region# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P58335 # Binding to PA seems to be effected through the VWA domain# Belongs to the ATR family &  Contains 1 VWFA domain

uniprot_information:
SwissProt: P58335 # Binding to PA seems to be effected through the VWA domain# Belongs to the ATR family &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q86SK9 # The histidine box domains may contain the active site and/or be involved in metal ion binding (By similarity)# Belongs to the fatty acid desaturase family

uniprot_information:
SwissProt: Q86SK9 # The histidine box domains may contain the active site and/or be involved in metal ion binding (By similarity)# Belongs to the fatty acid desaturase family


uniprot_information_type:
SwissProt: Q6MZP7 # The CXC domains mediate DNA-binding# Belongs to the lin-54 family &  Contains 2 CXC domains

uniprot_information:
SwissProt: Q6MZP7 # The CXC domains mediate DNA-binding# Belongs to the lin-54 family &  Contains 2 CXC domains


uniprot_information_type: SwissProt: Q8TDG4
uniprot_information:
Belongs to the helicase family. SKI2 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q6UWZ7 # The MPN-like region is similar to the MPN (JAB/Mov34) domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes# Belongs to the FAM175 family. Abraxas subfamily

uniprot_information:
SwissProt: Q6UWZ7 # The MPN-like region is similar to the MPN (JAB/Mov34) domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes# Belongs to the FAM175 family. Abraxas subfamily


uniprot_information_type:
SwissProt: P53779 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P53779 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P37840 # The NAC domain is involved in the fibril formation. The middle region forms the core of the filaments. The C-terminus may regulate aggregation and determine the diameter of the filaments# Belongs to the synuclein family

uniprot_information:
SwissProt: P37840 # The NAC domain is involved in the fibril formation. The middle region forms the core of the filaments. The C-terminus may regulate aggregation and determine the diameter of the filaments# Belongs to the synuclein family


uniprot_information_type:
SwissProt: Q8TEA7 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily &  Contains 1 protein kinase domain &  Contains 1 Rab-GAP TBC domain &  Contains 1 rhodanese domain

uniprot_information:
SwissProt: Q8TEA7 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily &  Contains 1 protein kinase domain &  Contains 1 Rab-GAP TBC domain &  Contains 1 rhodanese domain


uniprot_information_type:
SwissProt: Q9UBU2 # The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)# Belongs to the dickkopf family

uniprot_information:
SwissProt: Q9UBU2 # The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity)# Belongs to the dickkopf family


uniprot_information_type:
SwissProt: O76074 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B# Belongs to the cyclic nucleotide phosphodiesterase family &  Contains 2 GAF domains

uniprot_information:
SwissProt: O76074 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B# Belongs to the cyclic nucleotide phosphodiesterase family &  Contains 2 GAF domains


uniprot_information_type: SwissProt: P0CB38
uniprot_information:
Belongs to the polyadenylate-binding protein type-1 family &  Contains 4 RRM (RNA recognition motif) domains


uniprot_information_type:
SwissProt: Q8WTS6 # The SET domain is necessary but not sufficient for histone methyltransferase activity# Belongs to the histone-lysine methyltransferase family. SET7 subfamily &  Contains 3 MORN repeats &  Contains 1 SET domain

uniprot_information:
SwissProt: Q8WTS6 # The SET domain is necessary but not sufficient for histone methyltransferase activity# Belongs to the histone-lysine methyltransferase family. SET7 subfamily &  Contains 3 MORN repeats &  Contains 1 SET domain


uniprot_information_type:
SwissProt: Q96JK9 # The C-terminal domain is required for transcriptional activation# Belongs to the mastermind family

uniprot_information:
SwissProt: Q96JK9 # The C-terminal domain is required for transcriptional activation# Belongs to the mastermind family


uniprot_information_type:
SwissProt: Q96HF1 # The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the secreted frizzled-related protein (sFRP) family &  Contains 1 FZ (frizzled) domain &  Contains 1 NTR domain

uniprot_information:
SwissProt: Q96HF1 # The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the secreted frizzled-related protein (sFRP) family &  Contains 1 FZ (frizzled) domain &  Contains 1 NTR domain


uniprot_information_type: SwissProt: Q8N475
uniprot_information:
Contains 2 EF-hand domains &  Contains 2 Ig-like (immunoglobulin-like) domains &  Contains 1 Kazal-like domain


uniprot_information_type:
SwissProt: Q8TCQ1 # The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-CH-type zinc finger

uniprot_information:
SwissProt: Q8TCQ1 # The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-CH-type zinc finger


uniprot_information_type: SwissProt: Q5H9U9
uniprot_information:
Belongs to the helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q7Z6J0 # The RING finger domain is responsible of ubiquitination and proteasomal degradation# Belongs to the SH3RF family &  Contains 1 RING-type zinc finger &  Contains 4 SH3 domains

uniprot_information:
SwissProt: Q7Z6J0 # The RING finger domain is responsible of ubiquitination and proteasomal degradation# Belongs to the SH3RF family &  Contains 1 RING-type zinc finger &  Contains 4 SH3 domains


uniprot_information_type:
SwissProt: Q8WWX0 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q8WWX0 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: O96028
uniprot_information:
Belongs to the histone-lysine methyltransferase family. SET2 subfamily &  Contains 1 AWS domain &  Contains 1 HMG box DNA-binding domain &  Contains 4 PHD-type zinc fingers &  Contains 1 post-SET domain &  Contains 2 PWWP domains &  Contains 1 SET domain


uniprot_information_type: SwissProt: Q6ZSB9
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 7 C2H2-type zinc fingers


uniprot_information_type: SwissProt: P83110
uniprot_information:
Belongs to the peptidase S1B family &  Contains 1 IGFBP N-terminal domain &  Contains 1 Kazal-like domain &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: Q86Z14 # Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 241, and the second one lacks the essential Glu active site residue at position 889. These domains are therefore predicted to be inactive# Belongs to the glycosyl hydrolase 1 family. Klotho subfamily

uniprot_information:
SwissProt: Q86Z14 # Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 241, and the second one lacks the essential Glu active site residue at position 889. These domains are therefore predicted to be inactive# Belongs to the glycosyl hydrolase 1 family. Klotho subfamily


uniprot_information_type:
SwissProt: Q86UW6 # The Smr domain has nicking endonuclease activity, but no significant double strand cleavage or exonuclease activity# Contains 1 CUE domain &  Contains 1 Smr domain

uniprot_information:
SwissProt: Q86UW6 # The Smr domain has nicking endonuclease activity, but no significant double strand cleavage or exonuclease activity# Contains 1 CUE domain &  Contains 1 Smr domain


uniprot_information_type: SwissProt: Q9HAR2
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 1 GPS domain &  Contains 1 olfactomedin-like domain &  Contains 1 SUEL-type lectin domain


uniprot_information_type:
SwissProt: Q8TF72 # The ASD1 domain mediates F-actin binding (By similarity) &  The ASD2 domain is required for apical constriction induction (By similarity)# Belongs to the shroom family &  Contains 1 ASD1 domain &  Contains 1 ASD2 domain &  Contains 1 PDZ (DHR) domain

uniprot_information:
SwissProt: Q8TF72 # The ASD1 domain mediates F-actin binding (By similarity) &  The ASD2 domain is required for apical constriction induction (By similarity)# Belongs to the shroom family &  Contains 1 ASD1 domain &  Contains 1 ASD2 domain &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: Q86XX4 # The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding (By similarity)# Belongs to the FRAS1 family &  Contains 5 Calx-beta domains &  Contains 12 CSPG (NG2) repeats &  Contains 14 FU (furin-like) repeats &  Contains 6 VWFC domains

uniprot_information:
SwissProt: Q86XX4 # The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding (By similarity)# Belongs to the FRAS1 family &  Contains 5 Calx-beta domains &  Contains 12 CSPG (NG2) repeats &  Contains 14 FU (furin-like) repeats &  Contains 6 VWFC domains


uniprot_information_type:
SwissProt: Q53EU6 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

uniprot_information:
SwissProt: Q53EU6 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


uniprot_information_type:
SwissProt: Q8N264 # The coiled coil domain mediates the interaction with FLNA leading to its recruitment to lamellae# Contains 1 PH domain &  Contains 1 Rho-GAP domain

uniprot_information:
SwissProt: Q8N264 # The coiled coil domain mediates the interaction with FLNA leading to its recruitment to lamellae# Contains 1 PH domain &  Contains 1 Rho-GAP domain


uniprot_information_type: SwissProt: Q4W5G0
uniprot_information:
Belongs to the tigger transposable element derived protein family &  Contains 1 DDE domain &  Contains 1 HTH CENPB-type DNA-binding domain &  Contains 1 HTH psq-type DNA-binding domain


uniprot_information_type: SwissProt: Q9H4L7
uniprot_information:
Belongs to the SNF2/RAD54 helicase family &  Contains 2 CUE domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: O00238
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily &  Contains 1 GS domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q6UXI9 # The MAM domain is required for localization at the cell surface (By similarity)# Belongs to the nephronectin family &  Contains 5 EGF-like domains &  Contains 1 MAM domain

uniprot_information:
SwissProt: Q6UXI9 # The MAM domain is required for localization at the cell surface (By similarity)# Belongs to the nephronectin family &  Contains 5 EGF-like domains &  Contains 1 MAM domain


uniprot_information_type: SwissProt: Q96QP1
uniprot_information:
Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily &  Contains 1 alpha-type protein kinase domain


uniprot_information_type: SwissProt: Q96M93
uniprot_information:
Belongs to the ADAD family &  Contains 1 A to I editase domain &  Contains 1 DRBM (double-stranded RNA-binding) domain


uniprot_information_type:
SwissProt: Q6IE81 # The 2 PHD-type zinc fingers are required for transcriptional activity# Belongs to the JADE family &  Contains 2 PHD-type zinc fingers

uniprot_information:
SwissProt: Q6IE81 # The 2 PHD-type zinc fingers are required for transcriptional activity# Belongs to the JADE family &  Contains 2 PHD-type zinc fingers


uniprot_information_type:
SwissProt: Q8N568 # The doublecortin domains are involved in the colocalization with microtubules (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Contains 2 doublecortin domains &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q8N568 # The doublecortin domains are involved in the colocalization with microtubules (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Contains 2 doublecortin domains &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q02108
uniprot_information:
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family &  Contains 1 guanylate cyclase domain


uniprot_information_type: SwissProt: P48167
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRB sub-subfamily


uniprot_information_type:
SwissProt: Q86SF2 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q86SF2 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type: SwissProt: Q9H3E2
uniprot_information:
Belongs to the sorting nexin family &  Contains 1 PX (phox homology) domain &  Contains 1 PXA domain &  Contains 1 RGS domain


uniprot_information_type: SwissProt: Q13591
uniprot_information:
Belongs to the semaphorin family &  Contains 1 PSI domain &  Contains 1 Sema domain &  Contains 7 TSP type-1 domains


uniprot_information_type:
SwissProt: Q8TE73 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function# Belongs to the dynein heavy chain family

uniprot_information:
SwissProt: Q8TE73 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function# Belongs to the dynein heavy chain family


uniprot_information_type: SwissProt: Q9HD67
uniprot_information:
Contains 1 FERM domain &  Contains 3 IQ domains &  Contains 1 myosin head-like domain &  Contains 1 MyTH4 domain &  Contains 2 PH domains


uniprot_information_type: SwissProt: Q9C0I1
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily &  Contains 1 myotubularin phosphatase domain


uniprot_information_type:
SwissProt: P16471 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 1 subfamily &  Contains 2 fibronectin type-III domains

uniprot_information:
SwissProt: P16471 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 1 subfamily &  Contains 2 fibronectin type-III domains


uniprot_information_type:
SwissProt: P42702 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 6 fibronectin type-III domains

uniprot_information:
SwissProt: P42702 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 6 fibronectin type-III domains


uniprot_information_type:
SwissProt: A1L3X0 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the ELO family

uniprot_information:
SwissProt: A1L3X0 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the ELO family


uniprot_information_type:
SwissProt: Q9UKP5 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 5 TSP type-1 domains

uniprot_information:
SwissProt: Q9UKP5 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 5 TSP type-1 domains


uniprot_information_type:
SwissProt: Q9Y5P4 # The START domain recognizes ceramide and mediates the intermembrane transfer of ceramide &  The PH domain targets the Golgi apparatus &  The FFAT motif is required for interaction with VAPA and VAPB# Contains 1 PH domain &  Contains 1 START domain

uniprot_information:
SwissProt: Q9Y5P4 # The START domain recognizes ceramide and mediates the intermembrane transfer of ceramide &  The PH domain targets the Golgi apparatus &  The FFAT motif is required for interaction with VAPA and VAPB# Contains 1 PH domain &  Contains 1 START domain


uniprot_information_type:
SwissProt: Q86YM7 # The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3# Belongs to the Homer family &  Contains 1 WH1 domain

uniprot_information:
SwissProt: Q86YM7 # The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3# Belongs to the Homer family &  Contains 1 WH1 domain


uniprot_information_type: SwissProt: P10915
uniprot_information:
Belongs to the HAPLN family &  Contains 1 Ig-like V-type (immunoglobulin-like) domain &  Contains 2 Link domains


uniprot_information_type: SwissProt: Q9BVS4
uniprot_information:
Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: O14646 # The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3)# Belongs to the SNF2/RAD54 helicase family &  Contains 2 chromo domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain

uniprot_information:
SwissProt: O14646 # The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3)# Belongs to the SNF2/RAD54 helicase family &  Contains 2 chromo domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: Q9BQG2
uniprot_information:
Belongs to the Nudix hydrolase family. NudC subfamily &  Contains 3 ANK repeats &  Contains 1 nudix hydrolase domain


uniprot_information_type:
SwissProt: P49773 # The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide# Belongs to the HINT family &  Contains 1 HIT domain

uniprot_information:
SwissProt: P49773 # The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide# Belongs to the HINT family &  Contains 1 HIT domain


uniprot_information_type: SwissProt: Q8TEU7
uniprot_information:
Contains 1 cyclic nucleotide-binding domain &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 PDZ (DHR) domain &  Contains 1 Ras-associating domain &  Contains 1 Ras-GEF domain


uniprot_information_type:
SwissProt: Q2M3G4 # The ASD1 domain mediates F-actin binding (By similarity)# Belongs to the shroom family &  Contains 1 ASD1 domain &  Contains 1 ASD2 domain

uniprot_information:
SwissProt: Q2M3G4 # The ASD1 domain mediates F-actin binding (By similarity)# Belongs to the shroom family &  Contains 1 ASD1 domain &  Contains 1 ASD2 domain


uniprot_information_type:
SwissProt: Q8IVW4 # The [NKR]KIAxRE motif seems to be a cyclin-binding region# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q8IVW4 # The [NKR]KIAxRE motif seems to be a cyclin-binding region# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9HCX4
uniprot_information:
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily &  Contains 4 ANK repeats


uniprot_information_type: SwissProt: Q8WWN8
uniprot_information:
Contains 1 Arf-GAP domain &  Contains 3 PH domains &  Contains 1 Ras-associating domain &  Contains 1 Rho-GAP domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type: SwissProt: Q9NW64
uniprot_information:
Belongs to the SLT11 family &  Contains 1 C3H1-type zinc finger &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type: SwissProt: Q8TDQ0
uniprot_information:
Belongs to the immunoglobulin superfamily. TIM family &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: O95391 # The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway# Belongs to the SLU7 family &  Contains 1 CCHC-type zinc finger

uniprot_information:
SwissProt: O95391 # The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway# Belongs to the SLU7 family &  Contains 1 CCHC-type zinc finger


uniprot_information_type: SwissProt: P47870
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily


uniprot_information_type:
SwissProt: A1X283 # The PX domain is required for binding phosphoinositides and can also bind to the third SH3 domain (By similarity)# Belongs to the SH3PXD2 family &  Contains 1 PX (phox homology) domain &  Contains 4 SH3 domains

uniprot_information:
SwissProt: A1X283 # The PX domain is required for binding phosphoinositides and can also bind to the third SH3 domain (By similarity)# Belongs to the SH3PXD2 family &  Contains 1 PX (phox homology) domain &  Contains 4 SH3 domains


uniprot_information_type:
SwissProt: Q7L591 # PTB domain mediates receptor interaction (By similarity)# Belongs to the DOK family. Type A subfamily &  Contains 1 IRS-type PTB domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q7L591 # PTB domain mediates receptor interaction (By similarity)# Belongs to the DOK family. Type A subfamily &  Contains 1 IRS-type PTB domain &  Contains 1 PH domain


uniprot_information_type: SwissProt: Q9HAZ1
uniprot_information:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P45984 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P45984 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9C029 # The B30.2 domain mediates interaction with GYG. The coiled-coil region mediates homodimerization and heterodimerization# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q9C029 # The B30.2 domain mediates interaction with GYG. The coiled-coil region mediates homodimerization and heterodimerization# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q969F2 # The N-terminal domain comprising the first 217 amino acid residues is mostly unstructured# Belongs to the NKD family &  Contains 1 EF-hand domain

uniprot_information:
SwissProt: Q969F2 # The N-terminal domain comprising the first 217 amino acid residues is mostly unstructured# Belongs to the NKD family &  Contains 1 EF-hand domain


uniprot_information_type:
SwissProt: P16871 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 4 subfamily &  Contains 1 fibronectin type-III domain

uniprot_information:
SwissProt: P16871 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 4 subfamily &  Contains 1 fibronectin type-III domain


uniprot_information_type:
SwissProt: Q6KC79 # Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Belongs to the SCC2/Nipped-B family &  Contains 5 HEAT repeats

uniprot_information:
SwissProt: Q6KC79 # Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain# Belongs to the SCC2/Nipped-B family &  Contains 5 HEAT repeats


uniprot_information_type: SwissProt: Q63HQ2
uniprot_information:
Contains 3 EGF-like domains &  Contains 2 fibronectin type-III domains &  Contains 3 laminin G-like domains


uniprot_information_type:
SwissProt: Q99650 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding (By similarity) &  The box 1 motif is required for JAK interaction and/or activation (By similarity)# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 4 fibronectin type-III domains

uniprot_information:
SwissProt: Q99650 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding (By similarity) &  The box 1 motif is required for JAK interaction and/or activation (By similarity)# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 4 fibronectin type-III domains


uniprot_information_type:
SwissProt: P17301 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain

uniprot_information:
SwissProt: P17301 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain


uniprot_information_type: SwissProt: P19883
uniprot_information:
Contains 3 follistatin-like domains &  Contains 3 Kazal-like domains &  Contains 1 TB (TGF-beta binding) domain


uniprot_information_type: SwissProt: Q96RF0
uniprot_information:
Belongs to the sorting nexin family &  Contains 1 PX (phox homology) domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: Q8NI17
uniprot_information:
Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 5 fibronectin type-III domains


uniprot_information_type: SwissProt: Q13233
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily &  Contains 1 protein kinase domain &  Contains 1 RING-type zinc finger &  Contains 1 SWIM-type zinc finger


uniprot_information_type: SwissProt: Q9UI26
uniprot_information:
Belongs to the importin beta family &  Contains 15 HEAT repeats &  Contains 1 importin N-terminal domain


uniprot_information_type:
SwissProt: Q86T96 # The RING-type zinc finger domain mediates polyubiquitination of the interacting protein# Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q86T96 # The RING-type zinc finger domain mediates polyubiquitination of the interacting protein# Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q6MZT1 # The nuclear localization signal is both required for nuclear localization and palmitoylation (By similarity)# Belongs to the RGS7BP/RGS9BP family

uniprot_information:
SwissProt: Q6MZT1 # The nuclear localization signal is both required for nuclear localization and palmitoylation (By similarity)# Belongs to the RGS7BP/RGS9BP family


uniprot_information_type: SwissProt: Q96RT1
uniprot_information:
Belongs to the LAP (LRR and PDZ) protein family &  Contains 17 LRR (leucine-rich) repeats &  Contains 1 PDZ (DHR) domain


uniprot_information_type: SwissProt: O15021
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PDZ (DHR) domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q16625 # The C-terminal is cytoplasmic and is important for interaction with ZO-1. Sufficient for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction (By similarity). The first extracellular loop participates in an adhesive interaction# Belongs to the ELL/occludin family &  Contains 1 MARVEL domain

uniprot_information:
SwissProt: Q16625 # The C-terminal is cytoplasmic and is important for interaction with ZO-1. Sufficient for the tight junction localization. Involved in the regulation of the permeability barrier function of the tight junction (By similarity). The first extracellular loop participates in an adhesive interaction# Belongs to the ELL/occludin family &  Contains 1 MARVEL domain


uniprot_information_type:
SwissProt: P46821 # Has a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed intervals, which is responsible for the binding of MAP1B to microtubules# Belongs to the MAP1 family

uniprot_information:
SwissProt: P46821 # Has a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed intervals, which is responsible for the binding of MAP1B to microtubules# Belongs to the MAP1 family


uniprot_information_type: SwissProt: Q92973
uniprot_information:
Belongs to the importin beta family &  Contains 8 HEAT repeats &  Contains 1 importin N-terminal domain


uniprot_information_type: SwissProt: Q8N1W1
uniprot_information:
Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger


uniprot_information_type:
SwissProt: Q9UBT6 # The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity# Belongs to the DNA polymerase type-Y family &  Contains 2 Rad18-type zinc fingers &  Contains 1 umuC domain

uniprot_information:
SwissProt: Q9UBT6 # The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity# Belongs to the DNA polymerase type-Y family &  Contains 2 Rad18-type zinc fingers &  Contains 1 umuC domain


uniprot_information_type:
SwissProt: Q8N3K9 # Amphipathic helix regions act as an anchoring domain for PKA, and appear to be responsible of the interaction between myospryn and PRKAR2A# Contains 1 B30.2/SPRY domain &  Contains 2 fibronectin type-III domains

uniprot_information:
SwissProt: Q8N3K9 # Amphipathic helix regions act as an anchoring domain for PKA, and appear to be responsible of the interaction between myospryn and PRKAR2A# Contains 1 B30.2/SPRY domain &  Contains 2 fibronectin type-III domains


uniprot_information_type:
SwissProt: O14827 # The Ras-GEF domain and the N-terminal Ras-GEF domain form a Ras-binding site and mediate Ras activation (By similarity) &  The IQ domain mediates the calcium-dependent interaction with calmodulin but is dispensable for the Ras-GEF activity (By similarity) &  The DH (DBL-homology) domain mediates interaction with RASGRF1 and EPB49 and is required for RAC1 activation# Contains 1 DH (DBL-homology) domain &  Contains 1 IQ domain &  Contains 1 N-terminal Ras-GEF domain &  Contains 2 PH domains &  Contains 1 Ras-GEF domain

uniprot_information:
SwissProt: O14827 # The Ras-GEF domain and the N-terminal Ras-GEF domain form a Ras-binding site and mediate Ras activation (By similarity) &  The IQ domain mediates the calcium-dependent interaction with calmodulin but is dispensable for the Ras-GEF activity (By similarity) &  The DH (DBL-homology) domain mediates interaction with RASGRF1 and EPB49 and is required for RAC1 activation# Contains 1 DH (DBL-homology) domain &  Contains 1 IQ domain &  Contains 1 N-terminal Ras-GEF domain &  Contains 2 PH domains &  Contains 1 Ras-GEF domain


uniprot_information_type: SwissProt: Q8WXG9
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 35 Calx-beta domains &  Contains 6 EAR repeats &  Contains 1 GPS domain


uniprot_information_type:
SwissProt: O94955 # Although predicted to be a GTP-binding protein because of the presence of a Rho-like region, binds and hydrolyzes ATP. In contrast to Rho-like proteins, the conserved Asp residue in position 138 in the G4 region is replaced by an Asn, decreasing the ability to bind GTP# Contains 2 BTB (POZ) domains

uniprot_information:
SwissProt: O94955 # Although predicted to be a GTP-binding protein because of the presence of a Rho-like region, binds and hydrolyzes ATP. In contrast to Rho-like proteins, the conserved Asp residue in position 138 in the G4 region is replaced by an Asn, decreasing the ability to bind GTP# Contains 2 BTB (POZ) domains


uniprot_information_type: SwissProt: P16591
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily &  Contains 1 FCH domain &  Contains 1 protein kinase domain &  Contains 1 SH2 domain


uniprot_information_type: SwissProt: Q9Y6M4
uniprot_information:
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q96KG7 # The EMI and EGF-like domains work in concert to promote self-assembly# Belongs to the MEGF family &  Contains 15 EGF-like domains &  Contains 1 EMI domain

uniprot_information:
SwissProt: Q96KG7 # The EMI and EGF-like domains work in concert to promote self-assembly# Belongs to the MEGF family &  Contains 15 EGF-like domains &  Contains 1 EMI domain


uniprot_information_type:
SwissProt: Q9NRR3 # The CRIB domain mediates interaction with CDC42# Belongs to the CDC42SE/SPEC family &  Contains 1 CRIB domain

uniprot_information:
SwissProt: Q9NRR3 # The CRIB domain mediates interaction with CDC42# Belongs to the CDC42SE/SPEC family &  Contains 1 CRIB domain


uniprot_information_type: SwissProt: Q7L014
uniprot_information:
Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type: SwissProt: Q99717
uniprot_information:
Belongs to the dwarfin/SMAD family &  Contains 1 MH1 (MAD homology 1) domain &  Contains 1 MH2 (MAD homology 2) domain


uniprot_information_type:
SwissProt: Q9BPZ3 # Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation# Belongs to the PAIP2 family

uniprot_information:
SwissProt: Q9BPZ3 # Only the PABPC1-interacting motif-1 (PAM1) interferes with the binding of PABPC1 to poly(A) RNA and translation initiation# Belongs to the PAIP2 family


uniprot_information_type:
SwissProt: Q9UBS8 # The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway (By similarity) &  The RING-type zinc finger is essential for the interaction with UBE2E2# Belongs to the RBR family. RNF14 subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers &  Contains 1 RWD domain

uniprot_information:
SwissProt: Q9UBS8 # The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway (By similarity) &  The RING-type zinc finger is essential for the interaction with UBE2E2# Belongs to the RBR family. RNF14 subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers &  Contains 1 RWD domain


uniprot_information_type:
SwissProt: Q9BT67 # The PY (WW-binding) motifs are required for E3 ubiquitin-protein ligase binding and activation and for ubiquitination#

uniprot_information:
SwissProt: Q9BT67 # The PY (WW-binding) motifs are required for E3 ubiquitin-protein ligase binding and activation and for ubiquitination#


uniprot_information_type:
SwissProt: Q8TEC5 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Belongs to the SH3RF family &  Contains 1 RING-type zinc finger &  Contains 3 SH3 domains

uniprot_information:
SwissProt: Q8TEC5 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Belongs to the SH3RF family &  Contains 1 RING-type zinc finger &  Contains 3 SH3 domains


uniprot_information_type:
SwissProt: Q9P2N5 # The RRM domain mediates integration into cytospeckles (By similarity)# Contains 1 C3H1-type zinc finger &  Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q9P2N5 # The RRM domain mediates integration into cytospeckles (By similarity)# Contains 1 C3H1-type zinc finger &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: Q6PIJ6 # The N-terminal region aa 1-349 seems to be involved in cytoplasmic localization (By similarity) &  The C-terminal region aa 473-1194 seems to be involved in nuclear localization (By similarity)# Contains 1 F-box domain

uniprot_information:
SwissProt: Q6PIJ6 # The N-terminal region aa 1-349 seems to be involved in cytoplasmic localization (By similarity) &  The C-terminal region aa 473-1194 seems to be involved in nuclear localization (By similarity)# Contains 1 F-box domain


uniprot_information_type:
SwissProt: Q86YN6 # Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors (By similarity)# Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q86YN6 # Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors (By similarity)# Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: Q13283 # The NTF2 domain mediates multimerization# Contains 1 NTF2 domain &  Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q13283 # The NTF2 domain mediates multimerization# Contains 1 NTF2 domain &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: Q86SR1 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q86SR1 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: P83369 # The C-terminal SM 1 domain is both necessary for the binding to the Sm-binding site of U7 snRNA and U7 snRNP assembly (By similarity). The N-terminal domain is essential for histone pre-mRNA cleavage. Amino acids 63-82 are sufficient to interact with ZNF473# Belongs to the snRNP Sm proteins family

uniprot_information:
SwissProt: P83369 # The C-terminal SM 1 domain is both necessary for the binding to the Sm-binding site of U7 snRNA and U7 snRNP assembly (By similarity). The N-terminal domain is essential for histone pre-mRNA cleavage. Amino acids 63-82 are sufficient to interact with ZNF473# Belongs to the snRNP Sm proteins family


uniprot_information_type: SwissProt: P14867
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily


uniprot_information_type:
SwissProt: Q9NT68 # EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds &  Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins# Belongs to the tenascin family. Teneurin subfamily &  Contains 8 EGF-like domains &  Contains 5 NHL repeats &  Contains 1 teneurin N-terminal domain &  Contains 23 YD repeats

uniprot_information:
SwissProt: Q9NT68 # EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds &  Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins# Belongs to the tenascin family. Teneurin subfamily &  Contains 8 EGF-like domains &  Contains 5 NHL repeats &  Contains 1 teneurin N-terminal domain &  Contains 23 YD repeats


uniprot_information_type:
SwissProt: Q8IX03 # The C2-domain mediates homodimerization# Belongs to the WWC family. KIBRA subfamily &  Contains 1 C2 domain &  Contains 2 WW domains

uniprot_information:
SwissProt: Q8IX03 # The C2-domain mediates homodimerization# Belongs to the WWC family. KIBRA subfamily &  Contains 1 C2 domain &  Contains 2 WW domains


uniprot_information_type:
SwissProt: Q6ZN44 # The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis (By similarity)# Belongs to the unc-5 family &  Contains 1 death domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 TSP type-1 domain &  Contains 1 ZU5 domain

uniprot_information:
SwissProt: Q6ZN44 # The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis (By similarity)# Belongs to the unc-5 family &  Contains 1 death domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 TSP type-1 domain &  Contains 1 ZU5 domain


uniprot_information_type:
SwissProt: Q9UL40 # The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization (By similarity)# Contains 4 matrin-type zinc fingers

uniprot_information:
SwissProt: Q9UL40 # The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization (By similarity)# Contains 4 matrin-type zinc fingers


uniprot_information_type: SwissProt: B4DU55
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 13 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q86Y25 # KRAB domain is not required for nuclear targeting or for DNA binding (By similarity) &  Zinc finger region is involved in nuclear targeting and DNA-binding (By similarity)# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 11 C2H2-type zinc fingers &  Contains 1 KRAB domain

uniprot_information:
SwissProt: Q86Y25 # KRAB domain is not required for nuclear targeting or for DNA binding (By similarity) &  Zinc finger region is involved in nuclear targeting and DNA-binding (By similarity)# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 11 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q96T51 # The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate (By similarity)# Contains 1 FYVE-type zinc finger &  Contains 1 RUN domain

uniprot_information:
SwissProt: Q96T51 # The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate (By similarity)# Contains 1 FYVE-type zinc finger &  Contains 1 RUN domain


uniprot_information_type: SwissProt: Q6UXG8
uniprot_information:
Belongs to the immunoglobulin superfamily. BTN/MOG family &  Contains 1 B30.2/SPRY domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q96KP1 # Interacts with RALA through the TIG domain (By similarity)# Belongs to the SEC5 family &  Contains 1 IPT/TIG domain

uniprot_information:
SwissProt: Q96KP1 # Interacts with RALA through the TIG domain (By similarity)# Belongs to the SEC5 family &  Contains 1 IPT/TIG domain


uniprot_information_type:
SwissProt: P30740 # Reactive bond 1 is specific for reaction with chymotrypsin-like protease such as cathepsin G, chymotrypsin or chymase, while reactive bond 2 is specific for reaction with elastase-like protease such as neutrophyl elastase, proteinase-3, pancreatic elastase or PSA# Belongs to the serpin family. Ov-serpin subfamily

uniprot_information:
SwissProt: P30740 # Reactive bond 1 is specific for reaction with chymotrypsin-like protease such as cathepsin G, chymotrypsin or chymase, while reactive bond 2 is specific for reaction with elastase-like protease such as neutrophyl elastase, proteinase-3, pancreatic elastase or PSA# Belongs to the serpin family. Ov-serpin subfamily


uniprot_information_type:
SwissProt: P43307 # Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged# Belongs to the TRAP-alpha family

uniprot_information:
SwissProt: P43307 # Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged# Belongs to the TRAP-alpha family


uniprot_information_type: SwissProt: Q5JNZ3
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 14 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q9NU63 # The KRAB domain is required for function as transcriptional repressor (By similarity)# Belongs to the krueppel C2H2-type zinc-finger protein family. ZFP57 subfamily &  Contains 7 C2H2-type zinc fingers &  Contains 1 KRAB domain

uniprot_information:
SwissProt: Q9NU63 # The KRAB domain is required for function as transcriptional repressor (By similarity)# Belongs to the krueppel C2H2-type zinc-finger protein family. ZFP57 subfamily &  Contains 7 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: P36915 # In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern# Belongs to the MMR1/HSR1 GTP-binding protein family

uniprot_information:
SwissProt: P36915 # In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern# Belongs to the MMR1/HSR1 GTP-binding protein family


uniprot_information_type: SwissProt: Q99466
uniprot_information:
Belongs to the NOTCH family &  Contains 5 ANK repeats &  Contains 28 EGF-like domains &  Contains 3 LNR (Lin/Notch) repeats


uniprot_information_type: SwissProt: Q9Y3C6
uniprot_information:
Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily &  Contains 1 PPIase cyclophilin-type domain


uniprot_information_type: SwissProt: Q8NFP4
uniprot_information:
Contains 1 fibronectin type-III domain &  Contains 6 Ig-like (immunoglobulin-like) domains &  Contains 1 MAM domain


uniprot_information_type:
SwissProt: Q9ULH4 # The PDZ-binding motif is required for cell surface expression, neurite outgrowth promotion (By similarity). This motif is also involved in DLG1-, DLG3- and DLG4-binding# Belongs to the LRFN family &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 6 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q9ULH4 # The PDZ-binding motif is required for cell surface expression, neurite outgrowth promotion (By similarity). This motif is also involved in DLG1-, DLG3- and DLG4-binding# Belongs to the LRFN family &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 6 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q5JTZ9 # Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs (Potential)# Belongs to the class-II aminoacyl-tRNA synthetase family

uniprot_information:
SwissProt: Q5JTZ9 # Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs (Potential)# Belongs to the class-II aminoacyl-tRNA synthetase family


uniprot_information_type:
SwissProt: Q9NZA1 # Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity)# Belongs to the chloride channel CLIC family &  Contains 1 GST C-terminal domain

uniprot_information:
SwissProt: Q9NZA1 # Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity)# Belongs to the chloride channel CLIC family &  Contains 1 GST C-terminal domain


uniprot_information_type: SwissProt: Q5T601
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 1 GPS domain &  Contains 1 SEA domain


uniprot_information_type:
SwissProt: Q03001 # The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends# Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 2 EF-hand domains &  Contains 1 GAR domain &  Contains 23 LRR (leucine-rich) repeats &  Contains 5 plectin repeats &  Contains 1 SH3 domain &  Contains 20 spectrin repeats

uniprot_information:
SwissProt: Q03001 # The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends# Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 2 EF-hand domains &  Contains 1 GAR domain &  Contains 23 LRR (leucine-rich) repeats &  Contains 5 plectin repeats &  Contains 1 SH3 domain &  Contains 20 spectrin repeats


uniprot_information_type:
SwissProt: A6NGQ2 # Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA# Belongs to the KHDC1 family &  Contains 1 KH domain

uniprot_information:
SwissProt: A6NGQ2 # Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA# Belongs to the KHDC1 family &  Contains 1 KH domain


uniprot_information_type: SwissProt: Q99715
uniprot_information:
Belongs to the fibril-associated collagens with interrupted helices (FACIT) family &  Contains 18 fibronectin type-III domains &  Contains 1 TSP N-terminal (TSPN) domain &  Contains 4 VWFA domains


uniprot_information_type:
SwissProt: Q7Z6J8 # The C-terminal half (AA 188-389) is able to bind cyclin B and shows a self-ubiquitinylation activity (mono-, poly, or multi-ubiquitinylation) in a HECT-like sequence dependent manner#

uniprot_information:
SwissProt: Q7Z6J8 # The C-terminal half (AA 188-389) is able to bind cyclin B and shows a self-ubiquitinylation activity (mono-, poly, or multi-ubiquitinylation) in a HECT-like sequence dependent manner#


uniprot_information_type:
SwissProt: O60506 # The domain containing eight Arg-Gly-Gly repeats may be involved in RNA-binding and protein-protein interactions# Contains 3 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: O60506 # The domain containing eight Arg-Gly-Gly repeats may be involved in RNA-binding and protein-protein interactions# Contains 3 RRM (RNA recognition motif) domains


uniprot_information_type: SwissProt: Q8N3C0
uniprot_information:
Belongs to the helicase family &  Contains 2 helicase ATP-binding domains &  Contains 2 helicase C-terminal domains &  Contains 3 SEC63 domains


uniprot_information_type:
SwissProt: O60493 # The PX domain mediates specific binding to phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3)# Belongs to the sorting nexin family &  Contains 1 PX (phox homology) domain

uniprot_information:
SwissProt: O60493 # The PX domain mediates specific binding to phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3)# Belongs to the sorting nexin family &  Contains 1 PX (phox homology) domain


uniprot_information_type:
SwissProt: Q9HD26 # The PDZ domain mediates interactions with FZD5, FZD8, ACCN3, GRID2, CLCN3 (By similarity). Mediates also interaction with CFTR and ADRB1 &  The coiled-coil region probably mediates association to membranes, targeting to the Golgi, and interactions with GOLGA3, and STX6. May also mediate interaction with RHOQ (By similarity)# Contains 1 PDZ (DHR) domain

uniprot_information:
SwissProt: Q9HD26 # The PDZ domain mediates interactions with FZD5, FZD8, ACCN3, GRID2, CLCN3 (By similarity). Mediates also interaction with CFTR and ADRB1 &  The coiled-coil region probably mediates association to membranes, targeting to the Golgi, and interactions with GOLGA3, and STX6. May also mediate interaction with RHOQ (By similarity)# Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: Q149N8 # The RING finger mediates E3 ubiquitin ligase activity# Belongs to the SNF2/RAD54 helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 histone H1 domain &  Contains 1 PHD-type zinc finger &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q149N8 # The RING finger mediates E3 ubiquitin ligase activity# Belongs to the SNF2/RAD54 helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 histone H1 domain &  Contains 1 PHD-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q8WUA2
uniprot_information:
Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily &  Contains 1 PPIase cyclophilin-type domain &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type: SwissProt: Q86VZ4
uniprot_information:
Belongs to the LDLR family &  Contains 1 LDL-receptor class A domain &  Contains 1 MANSC domain &  Contains 1 PKD domain


uniprot_information_type:
SwissProt: Q8NF91 # The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains# Belongs to the nesprin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 12 HAT repeats &  Contains 1 KASH domain &  Contains 31 spectrin repeats

uniprot_information:
SwissProt: Q8NF91 # The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains# Belongs to the nesprin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 12 HAT repeats &  Contains 1 KASH domain &  Contains 31 spectrin repeats


uniprot_information_type:
SwissProt: Q9UKT4 # The C-terminal region is required for inhibition of APC activity# Contains 1 F-box domain &  Contains 1 IBR-type zinc finger

uniprot_information:
SwissProt: Q9UKT4 # The C-terminal region is required for inhibition of APC activity# Contains 1 F-box domain &  Contains 1 IBR-type zinc finger


uniprot_information_type: SwissProt: Q6P9H4
uniprot_information:
Belongs to the CNKSR family &  Contains 1 CRIC domain &  Contains 1 DUF1170 domain &  Contains 1 PDZ (DHR) domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type: SwissProt: Q8WVM0
uniprot_information:
Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily


uniprot_information_type:
SwissProt: Q9NRZ5 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

uniprot_information:
SwissProt: Q9NRZ5 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


uniprot_information_type: SwissProt: Q13546
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 1 death domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q6IEG0 # The CHHC region interacts with the 5' splice site of the U12-type intron# Contains 1 CHHC-type zinc finger

uniprot_information:
SwissProt: Q6IEG0 # The CHHC region interacts with the 5' splice site of the U12-type intron# Contains 1 CHHC-type zinc finger


uniprot_information_type:
SwissProt: Q8N6D2 # The RING-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8N6D2 # The RING-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q8WY64 # The RING domain mediates ubiquitination and the neurite outgrowth inhibitory activity# Contains 1 FERM domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8WY64 # The RING domain mediates ubiquitination and the neurite outgrowth inhibitory activity# Contains 1 FERM domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q8NB78 # The SWIRN domain may act as an anchor site for a histone tail (By similarity)# Belongs to the flavin monoamine oxidase family &  Contains 1 CW-type zinc finger &  Contains 1 SWIRM domain

uniprot_information:
SwissProt: Q8NB78 # The SWIRN domain may act as an anchor site for a histone tail (By similarity)# Belongs to the flavin monoamine oxidase family &  Contains 1 CW-type zinc finger &  Contains 1 SWIRM domain


uniprot_information_type:
SwissProt: Q7Z419 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity). The transmembrane domain is essential for translocation to the mitochondria upon induction of apoptosis# Belongs to the RBR family. RNF144 subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers

uniprot_information:
SwissProt: Q7Z419 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity). The transmembrane domain is essential for translocation to the mitochondria upon induction of apoptosis# Belongs to the RBR family. RNF144 subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers


uniprot_information_type: SwissProt: O15535
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: Q9P1U0
uniprot_information:
Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family &  Contains 1 TFIIS-type zinc finger


uniprot_information_type: SwissProt: Q9HCM9
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q8NE71
uniprot_information:
Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily &  Contains 2 ABC transporter domains


uniprot_information_type:
SwissProt: Q9H4E7 # The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding# Contains 1 PH domain

uniprot_information:
SwissProt: Q9H4E7 # The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding# Contains 1 PH domain


uniprot_information_type:
SwissProt: Q7Z6J4 # The FYVE-type zinc-finger is necessary for early endosome localization. Recruitement to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides (By similarity) &  The PH domain is necessary for localization to the ruffle membrane. Recruitement to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein (By similarity) &  The DH domain is necessary for its ability to activate JNK1 via CDC42 (By similarity)# Contains 1 DH (DBL-homology) domain &  Contains 1 FYVE-type zinc finger &  Contains 2 PH domains

uniprot_information:
SwissProt: Q7Z6J4 # The FYVE-type zinc-finger is necessary for early endosome localization. Recruitement to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides (By similarity) &  The PH domain is necessary for localization to the ruffle membrane. Recruitement to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein (By similarity) &  The DH domain is necessary for its ability to activate JNK1 via CDC42 (By similarity)# Contains 1 DH (DBL-homology) domain &  Contains 1 FYVE-type zinc finger &  Contains 2 PH domains


uniprot_information_type:
SwissProt: Q96JB1 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function# Belongs to the dynein heavy chain family

uniprot_information:
SwissProt: Q96JB1 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function# Belongs to the dynein heavy chain family


uniprot_information_type:
SwissProt: Q8IVH2 # The leucine-zipper is required for dimerization and transcriptional repression (By similarity)# Contains 1 C2H2-type zinc finger &  Contains 1 fork-head DNA-binding domain

uniprot_information:
SwissProt: Q8IVH2 # The leucine-zipper is required for dimerization and transcriptional repression (By similarity)# Contains 1 C2H2-type zinc finger &  Contains 1 fork-head DNA-binding domain


uniprot_information_type:
SwissProt: Q7Z7C8 # Ectopic expression of the histone fold domain acts as a dominant-negative mutant resulting in differentiation inhibition# Belongs to the TAF8 family &  Contains 1 histone-fold domain

uniprot_information:
SwissProt: Q7Z7C8 # Ectopic expression of the histone fold domain acts as a dominant-negative mutant resulting in differentiation inhibition# Belongs to the TAF8 family &  Contains 1 histone-fold domain


uniprot_information_type:
SwissProt: Q8IWT3 # The IBR domain is required for interaction with UBCH7 and UBCH8# Belongs to the cullin family &  Contains 1 DOC domain &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers

uniprot_information:
SwissProt: Q8IWT3 # The IBR domain is required for interaction with UBCH7 and UBCH8# Belongs to the cullin family &  Contains 1 DOC domain &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers


uniprot_information_type: SwissProt: Q5TCY1
uniprot_information:
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9Y253 # The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity# Belongs to the DNA polymerase type-Y family &  Contains 1 umuC domain

uniprot_information:
SwissProt: Q9Y253 # The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity# Belongs to the DNA polymerase type-Y family &  Contains 1 umuC domain


uniprot_information_type: SwissProt: Q86UR5
uniprot_information:
Contains 2 C2 domains &  Contains 1 FYVE-type zinc finger &  Contains 1 PDZ (DHR) domain &  Contains 1 RabBD (Rab-binding) domain


uniprot_information_type:
SwissProt: Q9NR82 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily

uniprot_information:
SwissProt: Q9NR82 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily


uniprot_information_type:
SwissProt: Q587J8 # Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA# Belongs to the KHDC1 family &  Contains 1 KH domain

uniprot_information:
SwissProt: Q587J8 # Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA# Belongs to the KHDC1 family &  Contains 1 KH domain


uniprot_information_type:
SwissProt: Q5VVH5 # The intrinsically disordered region interacts with HSPA1 and HSPA8 (By similarity)# Belongs to the IRAK1BP1 family

uniprot_information:
SwissProt: Q5VVH5 # The intrinsically disordered region interacts with HSPA1 and HSPA8 (By similarity)# Belongs to the IRAK1BP1 family


uniprot_information_type:
SwissProt: Q5TAB7 # The ripply homology domain is required for transcriptional repression (By similarity) &  The WRPW motif is required for binding to tle/groucho proteins (By similarity)# Belongs to the ripply family

uniprot_information:
SwissProt: Q5TAB7 # The ripply homology domain is required for transcriptional repression (By similarity) &  The WRPW motif is required for binding to tle/groucho proteins (By similarity)# Belongs to the ripply family


uniprot_information_type: SwissProt: P20265
uniprot_information:
Belongs to the POU transcription factor family. Class-3 subfamily &  Contains 1 homeobox DNA-binding domain &  Contains 1 POU-specific domain


uniprot_information_type: SwissProt: Q6ZN17
uniprot_information:
Belongs to the lin-28 family &  Contains 2 CCHC-type zinc fingers &  Contains 1 CSD (cold-shock) domain


uniprot_information_type:
SwissProt: O15131 # Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import &  The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity) &  The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)# Belongs to the importin alpha family &  Contains 10 ARM repeats &  Contains 1 IBB domain

uniprot_information:
SwissProt: O15131 # Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import &  The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity) &  The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity)# Belongs to the importin alpha family &  Contains 10 ARM repeats &  Contains 1 IBB domain


uniprot_information_type: SwissProt: Q8TC41
uniprot_information:
Belongs to the RBR family. RNF217 subfamily &  Contains 1 IBR-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9BXY4 # The FU repeats are required for activation and stabilization of beta-catenin (By similarity)# Belongs to the R-spondin family &  Contains 2 FU (furin-like) repeats &  Contains 1 TSP type-1 domain

uniprot_information:
SwissProt: Q9BXY4 # The FU repeats are required for activation and stabilization of beta-catenin (By similarity)# Belongs to the R-spondin family &  Contains 2 FU (furin-like) repeats &  Contains 1 TSP type-1 domain


uniprot_information_type: SwissProt: O14638
uniprot_information:
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family &  Contains 2 SMB (somatomedin-B) domains


uniprot_information_type:
SwissProt: P22413 # The di-leucine motif is required for basolateral targeting in epithelial cells, and for targeting to matrix vesicles derived from mineralizing cells (By similarity)# Belongs to the nucleotide pyrophosphatase/phosphodiesterase family &  Contains 2 SMB (somatomedin-B) domains

uniprot_information:
SwissProt: P22413 # The di-leucine motif is required for basolateral targeting in epithelial cells, and for targeting to matrix vesicles derived from mineralizing cells (By similarity)# Belongs to the nucleotide pyrophosphatase/phosphodiesterase family &  Contains 2 SMB (somatomedin-B) domains


uniprot_information_type:
SwissProt: Q9NP56 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain# Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily

uniprot_information:
SwissProt: Q9NP56 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain# Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily


uniprot_information_type: SwissProt: Q86SQ4
uniprot_information:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 1 CUB domain &  Contains 1 GPS domain &  Contains 1 pentaxin domain


uniprot_information_type: SwissProt: P46939
uniprot_information:
Contains 2 CH (calponin-homology) domains &  Contains 20 spectrin repeats &  Contains 1 WW domain &  Contains 1 ZZ-type zinc finger


uniprot_information_type:
SwissProt: Q6UB35 # This monofunctional enzyme consists of two major domains: an N-terminal inactive methylene-THF dehydrogenase and cyclohydrolase domain and an active larger formyl-THF synthetase C-terminal domain# In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family &  In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family

uniprot_information:
SwissProt: Q6UB35 # This monofunctional enzyme consists of two major domains: an N-terminal inactive methylene-THF dehydrogenase and cyclohydrolase domain and an active larger formyl-THF synthetase C-terminal domain# In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family &  In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family


uniprot_information_type:
SwissProt: Q02952 # Polybasic regions located between residues 266 and 557 are involved in binding PKC# Contains 3 AKAP domains

uniprot_information:
SwissProt: Q02952 # Polybasic regions located between residues 266 and 557 are involved in binding PKC# Contains 3 AKAP domains


uniprot_information_type:
SwissProt: Q8IVF5 # The PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure (By similarity)# Belongs to the TIAM family &  Contains 1 DH (DBL-homology) domain &  Contains 1 PDZ (DHR) domain &  Contains 2 PH domains &  Contains 1 RBD (Ras-binding) domain

uniprot_information:
SwissProt: Q8IVF5 # The PH 1 domain and amino acids 621-782 (a region called TSS; otherwise known as CC-Ex) are necessary for membrane localization. The PH 1 and TSS domains are necessary for Rac1 activity. The PH 2 domain is engaged in the enhancement of the catalytic activity of the adjacent DH domain. The PH 1, TSS and DH domains are necessary to induce neurite-like structure (By similarity)# Belongs to the TIAM family &  Contains 1 DH (DBL-homology) domain &  Contains 1 PDZ (DHR) domain &  Contains 2 PH domains &  Contains 1 RBD (Ras-binding) domain


uniprot_information_type:
SwissProt: Q9NRJ4 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the TUB family &  Contains 1 SOCS box domain &  Contains 3 WD repeats

uniprot_information:
SwissProt: Q9NRJ4 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the TUB family &  Contains 1 SOCS box domain &  Contains 3 WD repeats


uniprot_information_type:
SwissProt: P55196 # The PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich N-terminus domain interacts with F-actin# Contains 1 dilute domain &  Contains 1 FHA domain &  Contains 1 PDZ (DHR) domain &  Contains 2 Ras-associating domains

uniprot_information:
SwissProt: P55196 # The PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich N-terminus domain interacts with F-actin# Contains 1 dilute domain &  Contains 1 FHA domain &  Contains 1 PDZ (DHR) domain &  Contains 2 Ras-associating domains


uniprot_information_type: SwissProt: Q9H3U7
uniprot_information:
Contains 2 EF-hand domains &  Contains 1 Kazal-like domain &  Contains 2 thyroglobulin type-1 domains


uniprot_information_type:
SwissProt: Q9NWF9 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers

uniprot_information:
SwissProt: Q9NWF9 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers


uniprot_information_type: SwissProt: Q2UY09
uniprot_information:
Belongs to the VWA-containing collagen family &  Contains 1 BPTI/Kunitz inhibitor domain &  Contains 6 collagen-like domains &  Contains 2 VWFA domains


uniprot_information_type:
SwissProt: O75563 # The SH3 domain interacts with FYB and PTK2B# Belongs to the SKAP family &  Contains 1 PH domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: O75563 # The SH3 domain interacts with FYB and PTK2B# Belongs to the SKAP family &  Contains 1 PH domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q9BXU9 # The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting# Contains 2 EF-hand domains

uniprot_information:
SwissProt: Q9BXU9 # The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting# Contains 2 EF-hand domains


uniprot_information_type:
SwissProt: O00291 # The pseudo DED region (pDED) mediates the interaction with IFT57 &  Binds F-actin via the talin-like I/LWEQ domain# Belongs to the SLA2 family &  Contains 1 ENTH (epsin N-terminal homology) domain &  Contains 1 I/LWEQ domain

uniprot_information:
SwissProt: O00291 # The pseudo DED region (pDED) mediates the interaction with IFT57 &  Binds F-actin via the talin-like I/LWEQ domain# Belongs to the SLA2 family &  Contains 1 ENTH (epsin N-terminal homology) domain &  Contains 1 I/LWEQ domain


uniprot_information_type: SwissProt: Q9Y6J8
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily &  Contains 1 rhodanese domain &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type: SwissProt: Q9UJS0
uniprot_information:
Belongs to the mitochondrial carrier family &  Contains 4 EF-hand domains &  Contains 3 Solcar repeats


uniprot_information_type:
SwissProt: Q9UHR4 # The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity)# Contains 1 IMD (IRSp53/MIM homology) domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q9UHR4 # The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity)# Contains 1 IMD (IRSp53/MIM homology) domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: Q53GI3
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 7 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type:
SwissProt: O75420 # The GYF domain interacts with GRB10 (By similarity)# Belongs to the PERQ family &  Contains 1 GYF domain

uniprot_information:
SwissProt: O75420 # The GYF domain interacts with GRB10 (By similarity)# Belongs to the PERQ family &  Contains 1 GYF domain


uniprot_information_type:
SwissProt: A4D0S4 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domains VI and IV are globular# Contains 13 laminin EGF-like domains &  Contains 1 laminin IV type B domain &  Contains 1 laminin N-terminal domain

uniprot_information:
SwissProt: A4D0S4 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domains VI and IV are globular# Contains 13 laminin EGF-like domains &  Contains 1 laminin IV type B domain &  Contains 1 laminin N-terminal domain


uniprot_information_type:
SwissProt: Q8N1I0 # The DHR-2 domain probably mediates the GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q8N1I0 # The DHR-2 domain probably mediates the GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q9HBW1 # The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4 (By similarity)# Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 9 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q9HBW1 # The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4 (By similarity)# Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 9 LRR (leucine-rich) repeats


uniprot_information_type: SwissProt: Q6ZWJ8
uniprot_information:
Contains 1 TIL (trypsin inhibitory-like) domain &  Contains 17 VWFC domains &  Contains 1 VWFD domain


uniprot_information_type:
SwissProt: Q86WB0 # The F-box-like region is required for the interaction with SKP1A# Contains 1 C3HC-type zinc finger

uniprot_information:
SwissProt: Q86WB0 # The F-box-like region is required for the interaction with SKP1A# Contains 1 C3HC-type zinc finger


uniprot_information_type: SwissProt: Q9HCM2
uniprot_information:
Belongs to the plexin family &  Contains 4 IPT/TIG domains &  Contains 3 PSI domains &  Contains 1 Sema domain


uniprot_information_type:
SwissProt: Q7Z2W4 # The second and fourth zinc fingers are involved in binding to specific viral RNAs (By similarity)# Contains 4 C3H1-type zinc fingers &  Contains 1 PARP catalytic domain &  Contains 1 WWE domain

uniprot_information:
SwissProt: Q7Z2W4 # The second and fourth zinc fingers are involved in binding to specific viral RNAs (By similarity)# Contains 4 C3H1-type zinc fingers &  Contains 1 PARP catalytic domain &  Contains 1 WWE domain


uniprot_information_type: SwissProt: Q9H2X6
uniprot_information:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q6ZMT4 # The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 prevents its access to H3K9me2 &  The linker region is a critical determinant of demethylase specificity. It prevents the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3, while it favors selectivity toward H3K27me2# Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily &  Contains 1 JmjC domain &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: Q6ZMT4 # The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 prevents its access to H3K9me2 &  The linker region is a critical determinant of demethylase specificity. It prevents the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3, while it favors selectivity toward H3K27me2# Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily &  Contains 1 JmjC domain &  Contains 1 PHD-type zinc finger


uniprot_information_type: SwissProt: P15056
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain &  Contains 1 RBD (Ras-binding) domain


uniprot_information_type: SwissProt: Q8N393
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 16 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: Q6IV72
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 19 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: Q9ULD5
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 6 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: Q6NUN9
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 4 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q8NEZ4 # The SET domain interacts with histone H3 but not H2A, H2B and H4, and may have a H3 lysine specific methylation activity# Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily &  Contains 1 A.T hook DNA-binding domain &  Contains 1 DHHC-type zinc finger &  Contains 6 PHD-type zinc fingers &  Contains 1 post-SET domain &  Contains 1 RING-type zinc finger &  Contains 1 SET domain

uniprot_information:
SwissProt: Q8NEZ4 # The SET domain interacts with histone H3 but not H2A, H2B and H4, and may have a H3 lysine specific methylation activity# Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily &  Contains 1 A.T hook DNA-binding domain &  Contains 1 DHHC-type zinc finger &  Contains 6 PHD-type zinc fingers &  Contains 1 post-SET domain &  Contains 1 RING-type zinc finger &  Contains 1 SET domain


uniprot_information_type:
SwissProt: O94901 # The SUN domain may play a role in the nuclear anchoring and/or migration# Contains 1 SUN domain

uniprot_information:
SwissProt: O94901 # The SUN domain may play a role in the nuclear anchoring and/or migration# Contains 1 SUN domain


uniprot_information_type:
SwissProt: P55884 # The RRM domain mediates interaction with EIF3J# Belongs to the eIF-3 subunit B family &  Contains 1 RRM (RNA recognition motif) domain &  Contains 5 WD repeats

uniprot_information:
SwissProt: P55884 # The RRM domain mediates interaction with EIF3J# Belongs to the eIF-3 subunit B family &  Contains 1 RRM (RNA recognition motif) domain &  Contains 5 WD repeats


uniprot_information_type: SwissProt: Q7Z5N4
uniprot_information:
Contains 13 fibronectin type-III domains &  Contains 6 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q9NPG8 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q9NPG8 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type: SwissProt: Q2M3G0
uniprot_information:
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily &  Contains 1 ABC transmembrane type-1 domain &  Contains 2 ABC transporter domains


uniprot_information_type: SwissProt: Q9BXU1
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 1 protein kinase domain &  Contains 1 Tudor domain


uniprot_information_type:
SwissProt: A6NGB9 # The WH2 domain is found in a number of putative actin-binding proteins (By similarity) &  The profilin-binding motif has been implicated in the interaction with profilin and SH3 domains (By similarity) &  The KLKR motif is essential for G-actin binding and for actin polymerization (By similarity)# Belongs to the verprolin family &  Contains 1 WH2 domain

uniprot_information:
SwissProt: A6NGB9 # The WH2 domain is found in a number of putative actin-binding proteins (By similarity) &  The profilin-binding motif has been implicated in the interaction with profilin and SH3 domains (By similarity) &  The KLKR motif is essential for G-actin binding and for actin polymerization (By similarity)# Belongs to the verprolin family &  Contains 1 WH2 domain


uniprot_information_type:
SwissProt: Q8NHG8 # The RING-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8NHG8 # The RING-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q8N8U9
uniprot_information:
Contains 1 TIL (trypsin inhibitory-like) domain &  Contains 5 VWFC domains &  Contains 1 VWFD domain


uniprot_information_type:
SwissProt: Q9UJU6 # The SH3 domain mediates interaction with SHANK2, SHANK3 and PRAM1# Belongs to the ABP1 family &  Contains 1 ADF-H domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q9UJU6 # The SH3 domain mediates interaction with SHANK2, SHANK3 and PRAM1# Belongs to the ABP1 family &  Contains 1 ADF-H domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q8NF64 # The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein# Contains 1 SP-RING-type zinc finger

uniprot_information:
SwissProt: Q8NF64 # The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein# Contains 1 SP-RING-type zinc finger


uniprot_information_type: SwissProt: P62937
uniprot_information:
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily &  Contains 1 PPIase cyclophilin-type domain


uniprot_information_type:
SwissProt: Q13422 # The N-terminal zinc-fingers 2 and 3 are required for DNA binding as well as for targeting IKFZ1 to pericentromeric heterochromatin (By similarity) &  The C-terminal zinc-finger domain is required for dimerization (By similarity)# Belongs to the Ikaros C2H2-type zinc-finger protein family &  Contains 6 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q13422 # The N-terminal zinc-fingers 2 and 3 are required for DNA binding as well as for targeting IKFZ1 to pericentromeric heterochromatin (By similarity) &  The C-terminal zinc-finger domain is required for dimerization (By similarity)# Belongs to the Ikaros C2H2-type zinc-finger protein family &  Contains 6 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q6IS24 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q6IS24 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type: SwissProt: Q9P2G1
uniprot_information:
Belongs to the RBR family &  Contains 2 ANK repeats &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers &  Contains 1 UIM (ubiquitin-interacting motif) repeat


uniprot_information_type:
SwissProt: Q9ULJ8 # Interacts with p70-S6K via its PDZ domain (By similarity)# Contains 1 PDZ (DHR) domain &  Contains 1 SAM (sterile alpha motif) domain

uniprot_information:
SwissProt: Q9ULJ8 # Interacts with p70-S6K via its PDZ domain (By similarity)# Contains 1 PDZ (DHR) domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: Q9Y574 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q9Y574 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q8IWU2
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q6NSZ9
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 7 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type:
SwissProt: Q9Y493 # The MAM domains probably mediate sperm adhesion to the zona pellucida &  During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus &  The VWFD domain 2 may mediate covalent oligomerization (By similarity)# Contains 1 EGF-like domain &  Contains 3 MAM domains &  Contains 4 TIL (trypsin inhibitory-like) domains &  Contains 5 VWFC domains &  Contains 4 VWFD domains

uniprot_information:
SwissProt: Q9Y493 # The MAM domains probably mediate sperm adhesion to the zona pellucida &  During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus &  The VWFD domain 2 may mediate covalent oligomerization (By similarity)# Contains 1 EGF-like domain &  Contains 3 MAM domains &  Contains 4 TIL (trypsin inhibitory-like) domains &  Contains 5 VWFC domains &  Contains 4 VWFD domains


uniprot_information_type:
SwissProt: Q9UKN1 # The proteolytic cleavage occurs within the SEA domain. This domain is not interchangeable, suggesting that it is insufficient to mediate efficient cleavage# Contains 1 EGF-like domain &  Contains 1 SEA domain

uniprot_information:
SwissProt: Q9UKN1 # The proteolytic cleavage occurs within the SEA domain. This domain is not interchangeable, suggesting that it is insufficient to mediate efficient cleavage# Contains 1 EGF-like domain &  Contains 1 SEA domain


uniprot_information_type: SwissProt: Q9BRZ2
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 RING-type zinc finger


uniprot_information_type: P39880
uniprot_information:
Belongs to the CUT homeobox family &  Contains 3 CUT DNA-binding domains &  Contains 1 homeobox DNA-binding domain


uniprot_information_type: SwissProt: Q8IZD2
uniprot_information:
Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily &  Contains 1 PHD-type zinc finger &  Contains 1 SET domain


uniprot_information_type:
SwissProt: O15409 # The leucine-zipper is required for dimerization and transcriptional repression (By similarity)# Contains 1 C2H2-type zinc finger &  Contains 1 fork-head DNA-binding domain

uniprot_information:
SwissProt: O15409 # The leucine-zipper is required for dimerization and transcriptional repression (By similarity)# Contains 1 C2H2-type zinc finger &  Contains 1 fork-head DNA-binding domain


uniprot_information_type:
SwissProt: P13569 # The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex# Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily &  Contains 2 ABC transmembrane type-1 domains &  Contains 2 ABC transporter domains

uniprot_information:
SwissProt: P13569 # The PDZ-binding motif mediates interactions with GOPC and with the SLC4A7, SLC9A3R1/EBP50 complex# Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily &  Contains 2 ABC transmembrane type-1 domains &  Contains 2 ABC transporter domains


uniprot_information_type:
SwissProt: Q05682 # The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form# Belongs to the caldesmon family

uniprot_information:
SwissProt: Q05682 # The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form# Belongs to the caldesmon family


uniprot_information_type: SwissProt: A2VEC9
uniprot_information:
Belongs to the thrombospondin family &  Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 2 EGF-like domains &  Contains 1 EMI domain &  Contains 1 F5/8 type C domain &  Contains 10 LDL-receptor class A domains &  Contains 6 TIL (trypsin inhibitory-like) domains &  Contains 24 TSP type-1 domains &  Contains 3 VWFC domains &  Contains 3 VWFD domains


uniprot_information_type: SwissProt: P29474
uniprot_information:
Belongs to the NOS family &  Contains 1 FAD-binding FR-type domain &  Contains 1 flavodoxin-like domain


uniprot_information_type: SwissProt: Q9NUT2
uniprot_information:
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily &  Contains 1 ABC transmembrane type-1 domain &  Contains 1 ABC transporter domain


uniprot_information_type: SwissProt: Q96P47
uniprot_information:
Belongs to the centaurin gamma-like family &  Contains 3 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q7Z4T8 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily

uniprot_information:
SwissProt: Q7Z4T8 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily


uniprot_information_type:
SwissProt: Q86XI6 # The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to PYGL (By similarity)# Contains 1 CBM21 (carbohydrate binding type-21) domain

uniprot_information:
SwissProt: Q86XI6 # The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to PYGL (By similarity)# Contains 1 CBM21 (carbohydrate binding type-21) domain


uniprot_information_type:
SwissProt: Q96BK5 # The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity# Belongs to the PINX1 family &  Contains 1 G-patch domain

uniprot_information:
SwissProt: Q96BK5 # The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity# Belongs to the PINX1 family &  Contains 1 G-patch domain


uniprot_information_type:
SwissProt: Q9UPQ4 # The RING finger domain and the coiled-coil region are required for the apoptosis-inducing activity (By similarity)# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q9UPQ4 # The RING finger domain and the coiled-coil region are required for the apoptosis-inducing activity (By similarity)# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: P00390 # Each subunit can be divided into 4 domains that are consecutive along the polypeptide chain. Domains 1 and 2 bind FAD and NADPH, respectively. Domain 4 forms the interface# Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family

uniprot_information:
SwissProt: P00390 # Each subunit can be divided into 4 domains that are consecutive along the polypeptide chain. Domains 1 and 2 bind FAD and NADPH, respectively. Domain 4 forms the interface# Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family


uniprot_information_type: SwissProt: Q9BZ95
uniprot_information:
Belongs to the histone-lysine methyltransferase family. SET2 subfamily &  Contains 1 AWS domain &  Contains 4 PHD-type zinc fingers &  Contains 1 post-SET domain &  Contains 2 PWWP domains &  Contains 1 SET domain


uniprot_information_type:
SwissProt: P16157 # The 55 kDa regulatory domain is involved in regulating binding of SPTB/spectrin (beta chain) and SLC4A1/erythrocyte membrane protein band 3 &  The ANK repeat region forms a spiral around a large central cavity and is involved in binding of ion transporters# Contains 23 ANK repeats &  Contains 1 death domain &  Contains 1 ZU5 domain

uniprot_information:
SwissProt: P16157 # The 55 kDa regulatory domain is involved in regulating binding of SPTB/spectrin (beta chain) and SLC4A1/erythrocyte membrane protein band 3 &  The ANK repeat region forms a spiral around a large central cavity and is involved in binding of ion transporters# Contains 23 ANK repeats &  Contains 1 death domain &  Contains 1 ZU5 domain


uniprot_information_type: SwissProt: A1KZ92
uniprot_information:
Belongs to the peroxidase family. XPO subfamily &  Contains 4 Ig-like C2-type (immunoglobulin-like) domains &  Contains 6 LRR (leucine-rich) repeats &  Contains 1 VWFC domain


uniprot_information_type: SwissProt: Q96MG8
uniprot_information:
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family


uniprot_information_type:
SwissProt: Q13946 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain# Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily

uniprot_information:
SwissProt: Q13946 # Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain# Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily


uniprot_information_type: SwissProt: Q8IVN8
uniprot_information:
Belongs to the thrombospondin family &  Contains 1 SMB (somatomedin-B) domain &  Contains 1 TSP type-1 domain


uniprot_information_type:
SwissProt: Q9NUL3 # The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity)# Contains 4 DRBM (double-stranded RNA-binding) domains

uniprot_information:
SwissProt: Q9NUL3 # The DRBM 3 domain appears to be the major RNA-binding determinant. This domain also mediates interaction with XPO5 and is required for XPO1/CRM1-independent nuclear export (By similarity)# Contains 4 DRBM (double-stranded RNA-binding) domains


uniprot_information_type:
SwissProt: Q9HDC5 # The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids (By similarity)# Belongs to the junctophilin family &  Contains 7 MORN repeats

uniprot_information:
SwissProt: Q9HDC5 # The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids (By similarity)# Belongs to the junctophilin family &  Contains 7 MORN repeats


uniprot_information_type:
SwissProt: P02689 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior (By similarity)# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

uniprot_information:
SwissProt: P02689 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior (By similarity)# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


uniprot_information_type: SwissProt: Q9NQW8
uniprot_information:
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB3 subfamily &  Contains 1 cyclic nucleotide-binding domain


uniprot_information_type: SwissProt: Q9NV58
uniprot_information:
Belongs to the RBR family. RNF19 subfamily &  Contains 1 IBR-type zinc finger &  Contains 2 RING-type zinc fingers


uniprot_information_type: SwissProt: Q9UKY1
uniprot_information:
Belongs to the ZHX family &  Contains 2 C2H2-type zinc fingers &  Contains 5 homeobox DNA-binding domains


uniprot_information_type:
SwissProt: Q9ULH1 # The PH domain most probably contributes to the phosphoinositide-dependent regulation of ADP ribosylation factors (By similarity)# Contains 2 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 PH domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q9ULH1 # The PH domain most probably contributes to the phosphoinositide-dependent regulation of ADP ribosylation factors (By similarity)# Contains 2 ANK repeats &  Contains 1 Arf-GAP domain &  Contains 1 PH domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: Q8NFW1
uniprot_information:
Belongs to the fibril-associated collagens with interrupted helices (FACIT) family &  Contains 16 collagen-like domains &  Contains 1 TSP N-terminal (TSPN) domain &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q9UKV8 # The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH)# Belongs to the argonaute family. Ago subfamily &  Contains 1 PAZ domain &  Contains 1 Piwi domain

uniprot_information:
SwissProt: Q9UKV8 # The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH)# Belongs to the argonaute family. Ago subfamily &  Contains 1 PAZ domain &  Contains 1 Piwi domain


uniprot_information_type:
SwissProt: Q9NSY0 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q9NSY0 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9BWW7 # The N-terminal non zinc-finger region mediates the repressor activity# Belongs to the snail C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q9BWW7 # The N-terminal non zinc-finger region mediates the repressor activity# Belongs to the snail C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: O75593 # The FM region is required for binding SMAD2/SMAD4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated SMAD2 that is in an activated SMAD complex (By similarity)# Contains 1 fork-head DNA-binding domain

uniprot_information:
SwissProt: O75593 # The FM region is required for binding SMAD2/SMAD4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated SMAD2 that is in an activated SMAD complex (By similarity)# Contains 1 fork-head DNA-binding domain


uniprot_information_type: SwissProt: Q8TC21
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 11 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q8TCJ0 # The F-box is necessary for the interaction with SKP1 (By similarity)# Contains 1 F-box domain

uniprot_information:
SwissProt: Q8TCJ0 # The F-box is necessary for the interaction with SKP1 (By similarity)# Contains 1 F-box domain


uniprot_information_type:
SwissProt: Q9NUQ2 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

uniprot_information:
SwissProt: Q9NUQ2 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


uniprot_information_type:
SwissProt: Q8IV48 # The SAP domain is necessary for binding to the stem-loop structure of histone mRNAs and to form the ternary complex with SLBP, but not for 3'-end histone mRNA exonuclease activity# Contains 1 exonuclease domain &  Contains 1 SAP domain

uniprot_information:
SwissProt: Q8IV48 # The SAP domain is necessary for binding to the stem-loop structure of histone mRNAs and to form the ternary complex with SLBP, but not for 3'-end histone mRNA exonuclease activity# Contains 1 exonuclease domain &  Contains 1 SAP domain


uniprot_information_type:
SwissProt: Q969S2 # The zinc-finger domain is important for DNA binding# Belongs to the FPG family &  Contains 1 FPG-type zinc finger

uniprot_information:
SwissProt: Q969S2 # The zinc-finger domain is important for DNA binding# Belongs to the FPG family &  Contains 1 FPG-type zinc finger


uniprot_information_type:
SwissProt: Q9UIJ5 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q9UIJ5 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: Q9H7D0 # The DHR-2 domain may mediate some GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q9H7D0 # The DHR-2 domain may mediate some GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q9NPG1 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain

uniprot_information:
SwissProt: Q9NPG1 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain


uniprot_information_type:
SwissProt: Q93062 # The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity# Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q93062 # The RRM domain is necessary for interaction with SMAD4. Both the RRM domain and the C-terminus are required for TGFB1/Smad-mediated transactivation activity# Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: A8MYU2 # The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor (By similarity) &  The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity) &  The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel (By similarity) &  The C-terminal cytosolic region confers the pH-dependence (By similarity)# Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa5.1/KCNU1 sub-subfamily &  Contains 1 RCK N-terminal domain

uniprot_information:
SwissProt: A8MYU2 # The S4 segment, which is characterized by a series of positively charged amino acids at every third position, is part of the voltage-sensor (By similarity) &  The pore-forming domain (also referred as P region) is imbedded into the membrane, and forms the selectivity filter of the pore. It contains the signature sequence of potassium channels that displays selectivity to potassium (By similarity) &  The RCK N-terminal domain mediates the homotetramerization, thereby promoting the assembly of monomers into functional potassium channel (By similarity) &  The C-terminal cytosolic region confers the pH-dependence (By similarity)# Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa5.1/KCNU1 sub-subfamily &  Contains 1 RCK N-terminal domain


uniprot_information_type:
SwissProt: Q86UL3 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

uniprot_information:
SwissProt: Q86UL3 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


uniprot_information_type:
SwissProt: Q9NSN8 # The PDZ domain binds to the last three or four amino acids of DGKZ. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane# Belongs to the syntrophin family &  Contains 1 PDZ (DHR) domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q9NSN8 # The PDZ domain binds to the last three or four amino acids of DGKZ. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane# Belongs to the syntrophin family &  Contains 1 PDZ (DHR) domain &  Contains 1 PH domain


uniprot_information_type: SwissProt: Q9P2D1
uniprot_information:
Belongs to the SNF2/RAD54 helicase family &  Contains 2 chromo domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q8IUQ0 # The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2# Contains 1 CRAL-TRIO domain

uniprot_information:
SwissProt: Q8IUQ0 # The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2# Contains 1 CRAL-TRIO domain


uniprot_information_type: SwissProt: Q8IWW8
uniprot_information:
Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily


uniprot_information_type: SwissProt: Q96BR1
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain &  Contains 1 PX (phox homology) domain


uniprot_information_type:
SwissProt: Q70Z35 # PH domain confers substrate specificity and recognition. Able to discriminate between RAC1, RHOA, and CDC42 &  DH domain alone was unable to confer substrate specificity and recognition# Contains 2 DEP domains &  Contains 1 DH (DBL-homology) domain &  Contains 2 PDZ (DHR) domains &  Contains 1 PH domain

uniprot_information:
SwissProt: Q70Z35 # PH domain confers substrate specificity and recognition. Able to discriminate between RAC1, RHOA, and CDC42 &  DH domain alone was unable to confer substrate specificity and recognition# Contains 2 DEP domains &  Contains 1 DH (DBL-homology) domain &  Contains 2 PDZ (DHR) domains &  Contains 1 PH domain


uniprot_information_type: SwissProt: Q8TB36
uniprot_information:
Belongs to the GST superfamily &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain


uniprot_information_type: SwissProt: Q86UP3
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 20 C2H2-type zinc fingers &  Contains 4 homeobox DNA-binding domains


uniprot_information_type:
SwissProt: Q96CF2 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity)# Belongs to the SNF7 family

uniprot_information:
SwissProt: Q96CF2 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity)# Belongs to the SNF7 family


uniprot_information_type:
SwissProt: Q9ULS6 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.2/KCNS2 sub-subfamily

uniprot_information:
SwissProt: Q9ULS6 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.2/KCNS2 sub-subfamily


uniprot_information_type: SwissProt: Q8N573
uniprot_information:
Belongs to the OXR1 family &  Contains 1 GRAM domain &  Contains 1 LysM repeat &  Contains 1 TLD domain


uniprot_information_type:
SwissProt: Q8IWU4 # Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc (By similarity)# Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily

uniprot_information:
SwissProt: Q8IWU4 # Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc (By similarity)# Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily


uniprot_information_type: SwissProt: Q96RU8
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8TCX5 # The PDZ domain mediates interaction with ROPN1 (By similarity)# Belongs to the RHPN family &  Contains 1 BRO1 domain &  Contains 1 PDZ (DHR) domain &  Contains 1 REM (Hr1) repeat

uniprot_information:
SwissProt: Q8TCX5 # The PDZ domain mediates interaction with ROPN1 (By similarity)# Belongs to the RHPN family &  Contains 1 BRO1 domain &  Contains 1 PDZ (DHR) domain &  Contains 1 REM (Hr1) repeat


uniprot_information_type:
SwissProt: Q8TD08 # The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteosomal degradation (By similarity) &  The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q8TD08 # The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteosomal degradation (By similarity) &  The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8IVQ6 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q8IVQ6 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: Q5H8C1 # The Calx-beta domain binds calcium with high affinity and undergo a major conformational shift upon binding (By similarity)# Belongs to the FRAS1 family &  Contains 1 C-type lectin domain &  Contains 1 Calx-beta domain &  Contains 12 CSPG (NG2) repeats

uniprot_information:
SwissProt: Q5H8C1 # The Calx-beta domain binds calcium with high affinity and undergo a major conformational shift upon binding (By similarity)# Belongs to the FRAS1 family &  Contains 1 C-type lectin domain &  Contains 1 Calx-beta domain &  Contains 12 CSPG (NG2) repeats


uniprot_information_type: SwissProt: Q9Y263
uniprot_information:
Belongs to the WD repeat PLAP family &  Contains 1 PFU domain &  Contains 1 PUL domain &  Contains 7 WD repeats


uniprot_information_type:
SwissProt: O95786 # The repressor domain controls homomultimerization and interaction with MAVS (Probable) &  The helicase domain is responsible for dsRNA recognition &  The 2 CARD domains are responsible for interaction with and signaling through MAVS &  The second CARD domain is the primary site for 'Lys-63'-linked ubiquitination# Belongs to the helicase family &  Contains 2 CARD domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain

uniprot_information:
SwissProt: O95786 # The repressor domain controls homomultimerization and interaction with MAVS (Probable) &  The helicase domain is responsible for dsRNA recognition &  The 2 CARD domains are responsible for interaction with and signaling through MAVS &  The second CARD domain is the primary site for 'Lys-63'-linked ubiquitination# Belongs to the helicase family &  Contains 2 CARD domains &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q7Z2E3 # The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide (By similarity) &  The FHA-like domain mediates interaction with NCL; XRCC1 and XRCC4 &  The HIT domain is required for enzymatic activity &  The C2H2-type zinc finger mediates DNA-binding# Contains 1 C2H2-type zinc finger &  Contains 1 FHA-like domain &  Contains 1 HIT domain

uniprot_information:
SwissProt: Q7Z2E3 # The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide (By similarity) &  The FHA-like domain mediates interaction with NCL; XRCC1 and XRCC4 &  The HIT domain is required for enzymatic activity &  The C2H2-type zinc finger mediates DNA-binding# Contains 1 C2H2-type zinc finger &  Contains 1 FHA-like domain &  Contains 1 HIT domain


uniprot_information_type: SwissProt: Q2TAY7
uniprot_information:
Belongs to the WD repeat SMU1 family &  Contains 1 CTLH domain &  Contains 1 LisH domain &  Contains 6 WD repeats


uniprot_information_type:
SwissProt: P07951 # The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity# Belongs to the tropomyosin family

uniprot_information:
SwissProt: P07951 # The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity# Belongs to the tropomyosin family


uniprot_information_type:
SwissProt: Q9BX68 # The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide# Belongs to the HINT family &  Contains 1 HIT domain

uniprot_information:
SwissProt: Q9BX68 # The histidine triad, also called HIT motif, forms part of the binding loop for the alpha-phosphate of purine mononucleotide# Belongs to the HINT family &  Contains 1 HIT domain


uniprot_information_type:
SwissProt: Q15464 # The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII# Contains 1 SH2 domain

uniprot_information:
SwissProt: Q15464 # The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII# Contains 1 SH2 domain


uniprot_information_type: SwissProt: Q8WX77
uniprot_information:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 IGFBP N-terminal domain &  Contains 1 Kazal-like domain


uniprot_information_type:
SwissProt: Q02410 # Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane# Contains 2 PDZ (DHR) domains &  Contains 1 PID domain

uniprot_information:
SwissProt: Q02410 # Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane# Contains 2 PDZ (DHR) domains &  Contains 1 PID domain


uniprot_information_type: SwissProt: Q9BX84
uniprot_information:
In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily &  In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily &  Contains 1 alpha-type protein kinase domain


uniprot_information_type:
SwissProt: Q9UMX0 # Binds PSEN1 and PSEN2 via its UBA domain# Contains 1 UBA domain &  Contains 1 ubiquitin-like domain

uniprot_information:
SwissProt: Q9UMX0 # Binds PSEN1 and PSEN2 via its UBA domain# Contains 1 UBA domain &  Contains 1 ubiquitin-like domain


uniprot_information_type:
SwissProt: Q9BXN1 # The LRR 5 repeat can inhibit BMP2-induced cytodifferentiation and may be involved in the interaction with BMP2 (By similarity). The repeats LRR 10, LRR 11 and LRR 12 are involved in binding type I collagen. The poly-Asp region is involved in binding calcium# Belongs to the small leucine-rich proteoglycan (SLRP) family. Class I subfamily &  Contains 12 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q9BXN1 # The LRR 5 repeat can inhibit BMP2-induced cytodifferentiation and may be involved in the interaction with BMP2 (By similarity). The repeats LRR 10, LRR 11 and LRR 12 are involved in binding type I collagen. The poly-Asp region is involved in binding calcium# Belongs to the small leucine-rich proteoglycan (SLRP) family. Class I subfamily &  Contains 12 LRR (leucine-rich) repeats


uniprot_information_type: SwissProt: Q6ZMW2
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 15 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: Q4LDE5
uniprot_information:
Contains 9 EGF-like domains &  Contains 2 HYR domains &  Contains 1 pentaxin domain &  Contains 34 Sushi (CCP/SCR) domains &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q5T1M5 # The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity (By similarity) &  The central coiled-coil region is responsible for association with early endosomes# Belongs to the FKBP-type PPIase family &  Contains 1 PPIase FKBP-type domain

uniprot_information:
SwissProt: Q5T1M5 # The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity (By similarity) &  The central coiled-coil region is responsible for association with early endosomes# Belongs to the FKBP-type PPIase family &  Contains 1 PPIase FKBP-type domain


uniprot_information_type:
SwissProt: Q13077 # The coiled coil domain mediates homo- and hetero-oligomerization &  The MATH/TRAF domain binds to receptor cytoplasmic domains# Contains 1 MATH domain

uniprot_information:
SwissProt: Q13077 # The coiled coil domain mediates homo- and hetero-oligomerization &  The MATH/TRAF domain binds to receptor cytoplasmic domains# Contains 1 MATH domain


uniprot_information_type:
SwissProt: Q08379 # Extended rod-like protein with coiled-coil domains# Belongs to the GOLGA2 family

uniprot_information:
SwissProt: Q08379 # Extended rod-like protein with coiled-coil domains# Belongs to the GOLGA2 family


uniprot_information_type:
SwissProt: Q96GR4 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q96GR4 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: Q9NWX5 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q9NWX5 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 6 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q96RU3
uniprot_information:
Belongs to the FNBP1 family &  Contains 1 FCH domain &  Contains 1 REM (Hr1) repeat &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: Q9H8H2
uniprot_information:
Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q8N5D6 # The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity)# Belongs to the glycosyltransferase 6 family

uniprot_information:
SwissProt: Q8N5D6 # The conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis (By similarity)# Belongs to the glycosyltransferase 6 family


uniprot_information_type:
SwissProt: O15260 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins# Belongs to the SURF4 family

uniprot_information:
SwissProt: O15260 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins# Belongs to the SURF4 family


uniprot_information_type:
SwissProt: Q5T5Y3 # The CKK domain binds microtubules# Belongs to the CAMSAP1 family &  Contains 1 CH (calponin-homology) domain &  Contains 1 CKK domain

uniprot_information:
SwissProt: Q5T5Y3 # The CKK domain binds microtubules# Belongs to the CAMSAP1 family &  Contains 1 CH (calponin-homology) domain &  Contains 1 CKK domain


uniprot_information_type: SwissProt: P46531
uniprot_information:
Belongs to the NOTCH family &  Contains 5 ANK repeats &  Contains 36 EGF-like domains &  Contains 3 LNR (Lin/Notch) repeats


uniprot_information_type: SwissProt: Q6ZV29
uniprot_information:
Belongs to the NTE family &  Contains 3 cyclic nucleotide-binding domains &  Contains 1 patatin domain


uniprot_information_type:
SwissProt: Q8NF50 # The DHR-2 domain may mediate some GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain

uniprot_information:
SwissProt: Q8NF50 # The DHR-2 domain may mediate some GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain


uniprot_information_type: SwissProt: Q9NZQ7
uniprot_information:
Belongs to the immunoglobulin superfamily. BTN/MOG family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: Q96PU4
uniprot_information:
Contains 1 PHD-type zinc finger &  Contains 2 RING-type zinc fingers &  Contains 1 ubiquitin-like domain &  Contains 1 YDG domain


uniprot_information_type: SwissProt: Q8N6G6
uniprot_information:
Contains 4 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 PLAC domain &  Contains 9 TSP type-1 domains


uniprot_information_type: SwissProt: Q5VZ89
uniprot_information:
Contains 1 dDENN domain &  Contains 1 DENN domain &  Contains 1 PPR (pentatricopeptide) repeat &  Contains 1 uDENN domain


uniprot_information_type: SwissProt: Q9UDY2
uniprot_information:
Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 3 PDZ (DHR) domains &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q8IY18 # The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC6, forming a V-shaped heterodimer (By similarity)# Belongs to the SMC family. SMC5 subfamily

uniprot_information:
SwissProt: Q8IY18 # The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC6, forming a V-shaped heterodimer (By similarity)# Belongs to the SMC family. SMC5 subfamily


uniprot_information_type: SwissProt: Q16620
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 2 LRR (leucine-rich) repeats &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: P43405
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily &  Contains 1 protein kinase domain &  Contains 2 SH2 domains


uniprot_information_type: SwissProt: Q9Y3S1
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: A2A3K4
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class PTPDC1 subfamily &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type: Q5T890
uniprot_information:
Belongs to the SNF2/RAD54 helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q8IXK2 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q8IXK2 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: Q9NVV0 # The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore (By similarity)# Belongs to the TMEM38 family

uniprot_information:
SwissProt: Q9NVV0 # The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore (By similarity)# Belongs to the TMEM38 family


uniprot_information_type:
SwissProt: P54727 # The ubiquitin-like domain mediates interaction with MJD# Belongs to the RAD23 family &  Contains 1 STI1 domain &  Contains 2 UBA domains &  Contains 1 ubiquitin-like domain

uniprot_information:
SwissProt: P54727 # The ubiquitin-like domain mediates interaction with MJD# Belongs to the RAD23 family &  Contains 1 STI1 domain &  Contains 2 UBA domains &  Contains 1 ubiquitin-like domain


uniprot_information_type:
SwissProt: Q9Y2D5 # The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer#

uniprot_information:
SwissProt: Q9Y2D5 # The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer#


uniprot_information_type: SwissProt: O15146
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family &  Contains 1 FZ (frizzled) domain &  Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q8TF39
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 11 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: Q8IZC6
uniprot_information:
Belongs to the fibrillar collagen family &  Contains 16 collagen-like domains &  Contains 1 fibrillar collagen NC1 domain &  Contains 1 laminin G-like domain &  Contains 1 TSP N-terminal (TSPN) domain


uniprot_information_type: SwissProt: Q13049
uniprot_information:
Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 5 NHL repeats &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: O00206 # The TIR domain mediates interaction with NOX4# Belongs to the Toll-like receptor family &  Contains 21 LRR (leucine-rich) repeats &  Contains 1 TIR domain

uniprot_information:
SwissProt: O00206 # The TIR domain mediates interaction with NOX4# Belongs to the Toll-like receptor family &  Contains 21 LRR (leucine-rich) repeats &  Contains 1 TIR domain


uniprot_information_type:
SwissProt: Q5VWQ8 # The C2 and Ras-GAP domains are required for the interaction with MAP3K5# Contains 1 C2 domain &  Contains 1 PH domain &  Contains 1 Ras-GAP domain

uniprot_information:
SwissProt: Q5VWQ8 # The C2 and Ras-GAP domains are required for the interaction with MAP3K5# Contains 1 C2 domain &  Contains 1 PH domain &  Contains 1 Ras-GAP domain


uniprot_information_type: SwissProt: Q9HC98
uniprot_information:
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O43298
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 3 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q6UWE0 # The coiled coil domains interact with the SB domain of TSG101 &  The PTAP motifs mediate the binding to UEV domains# Contains 5 LRR (leucine-rich) repeats &  Contains 1 RING-type zinc finger &  Contains 1 SAM (sterile alpha motif) domain

uniprot_information:
SwissProt: Q6UWE0 # The coiled coil domains interact with the SB domain of TSG101 &  The PTAP motifs mediate the binding to UEV domains# Contains 5 LRR (leucine-rich) repeats &  Contains 1 RING-type zinc finger &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type: SwissProt: Q6KCM7
uniprot_information:
Belongs to the mitochondrial carrier family &  Contains 3 EF-hand domains &  Contains 3 Solcar repeats


uniprot_information_type: SwissProt: Q13813
uniprot_information:
Belongs to the spectrin family &  Contains 3 EF-hand domains &  Contains 1 SH3 domain &  Contains 23 spectrin repeats


uniprot_information_type:
SwissProt: Q6P5Z2 # The C1 domain does not bind the diacylglycerol (DAG)# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain &  Contains 3 REM (Hr1) repeats

uniprot_information:
SwissProt: Q6P5Z2 # The C1 domain does not bind the diacylglycerol (DAG)# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain &  Contains 3 REM (Hr1) repeats


uniprot_information_type: SwissProt: Q8NDA2
uniprot_information:
Contains 5 EGF-like domains &  Contains 42 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 nidogen G2 beta-barrel domain &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q5VTD9 # The zinc finger domains are essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain (By similarity)# Contains 6 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q5VTD9 # The zinc finger domains are essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain (By similarity)# Contains 6 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q8NE28 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q8NE28 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q76LX8 # The pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency &  The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction# Contains 2 CUB domains &  Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 8 TSP type-1 domains

uniprot_information:
SwissProt: Q76LX8 # The pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency &  The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction# Contains 2 CUB domains &  Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 8 TSP type-1 domains


uniprot_information_type:
SwissProt: Q86YR5 # The GoLoco domains mediate interaction with G(i/o) alpha (By similarity). The GoLoco domains are essential for the GDI activity toward G(i/o) alpha# Belongs to the GPSM family &  Contains 4 GoLoco domains &  Contains 9 TPR repeats

uniprot_information:
SwissProt: Q86YR5 # The GoLoco domains mediate interaction with G(i/o) alpha (By similarity). The GoLoco domains are essential for the GDI activity toward G(i/o) alpha# Belongs to the GPSM family &  Contains 4 GoLoco domains &  Contains 9 TPR repeats


uniprot_information_type: SwissProt: Q9UHB4
uniprot_information:
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family &  Contains 1 FAD-binding FR-type domain &  Contains 1 flavodoxin-like domain


uniprot_information_type:
SwissProt: Q86UR1 # The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function &  The TPR repeats mediate interaction with RAC1# Belongs to the NCF2/NOXA1 family &  Contains 1 OPR domain &  Contains 1 SH3 domain &  Contains 4 TPR repeats

uniprot_information:
SwissProt: Q86UR1 # The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function &  The TPR repeats mediate interaction with RAC1# Belongs to the NCF2/NOXA1 family &  Contains 1 OPR domain &  Contains 1 SH3 domain &  Contains 4 TPR repeats


uniprot_information_type:
SwissProt: Q9H9B1 # The SET domain mediates interaction with WIZ# Belongs to the histone-lysine methyltransferase family &  Contains 8 ANK repeats &  Contains 1 pre-SET domain &  Contains 1 SET domain

uniprot_information:
SwissProt: Q9H9B1 # The SET domain mediates interaction with WIZ# Belongs to the histone-lysine methyltransferase family &  Contains 8 ANK repeats &  Contains 1 pre-SET domain &  Contains 1 SET domain


uniprot_information_type:
SwissProt: Q00975 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily &  Contains 1 EF-hand domain

uniprot_information:
SwissProt: Q00975 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily &  Contains 1 EF-hand domain


uniprot_information_type:
SwissProt: Q96B97 # The SH3 domains mediate interaction with SHKBP1 (By similarity)# Contains 3 SH3 domains

uniprot_information:
SwissProt: Q96B97 # The SH3 domains mediate interaction with SHKBP1 (By similarity)# Contains 3 SH3 domains


uniprot_information_type: SwissProt: P51812
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 2 protein kinase domains


uniprot_information_type:
SwissProt: O14936 # The first L27 domain binds DLG1 and the second L27 domain probably binds LIN7 (By similarity) &  The protein kinase domain mediates the interaction with FCHSD2# In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 2 L27 domains &  Contains 1 PDZ (DHR) domain &  Contains 1 protein kinase domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: O14936 # The first L27 domain binds DLG1 and the second L27 domain probably binds LIN7 (By similarity) &  The protein kinase domain mediates the interaction with FCHSD2# In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 2 L27 domains &  Contains 1 PDZ (DHR) domain &  Contains 1 protein kinase domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P41229 # The first PHD-type zinc finger domain recognizes and binds H3-K9Me3 &  Both the JmjC domain and the JmjN domain are required for enzymatic activity# Belongs to the JARID1 histone demethylase family &  Contains 1 ARID domain &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 2 PHD-type zinc fingers

uniprot_information:
SwissProt: P41229 # The first PHD-type zinc finger domain recognizes and binds H3-K9Me3 &  Both the JmjC domain and the JmjN domain are required for enzymatic activity# Belongs to the JARID1 histone demethylase family &  Contains 1 ARID domain &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 2 PHD-type zinc fingers


uniprot_information_type: SwissProt: Q5JU85
uniprot_information:
Belongs to the BRAG family &  Contains 1 IQ domain &  Contains 1 PH domain &  Contains 1 SEC7 domain


uniprot_information_type:
SwissProt: Q14683 # The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity)# Belongs to the SMC family. SMC1 subfamily

uniprot_information:
SwissProt: Q14683 # The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity)# Belongs to the SMC family. SMC1 subfamily


uniprot_information_type:
SwissProt: Q7Z6Z7 # The HECT domain mediates inhibition of the transcriptional activity of p53# Belongs to the TOM1/PTR1 family &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 1 UBA domain &  Contains 1 UIM (ubiquitin-interacting motif) repeat &  Contains 1 WWE domain

uniprot_information:
SwissProt: Q7Z6Z7 # The HECT domain mediates inhibition of the transcriptional activity of p53# Belongs to the TOM1/PTR1 family &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 1 UBA domain &  Contains 1 UIM (ubiquitin-interacting motif) repeat &  Contains 1 WWE domain


uniprot_information_type:
SwissProt: Q8WXK4 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 5 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q8WXK4 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 5 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: Q9H1B4 # The NTF2 domain heterodimerizes with NXT1 and NXT2 (By similarity)# Belongs to the NXF family &  Contains 4 LRR (leucine-rich) repeats &  Contains 1 NTF2 domain &  Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q9H1B4 # The NTF2 domain heterodimerizes with NXT1 and NXT2 (By similarity)# Belongs to the NXF family &  Contains 4 LRR (leucine-rich) repeats &  Contains 1 NTF2 domain &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: Q9Y397 # The DHHC domain is required for palmitoyltransferase activity# Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q9Y397 # The DHHC domain is required for palmitoyltransferase activity# Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily &  Contains 1 DHHC-type zinc finger


uniprot_information_type: SwissProt: P51815
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: Q9NYK1
uniprot_information:
Belongs to the Toll-like receptor family &  Contains 27 LRR (leucine-rich) repeats &  Contains 1 TIR domain


uniprot_information_type: SwissProt: Q9NR97
uniprot_information:
Belongs to the Toll-like receptor family &  Contains 24 LRR (leucine-rich) repeats &  Contains 1 TIR domain


uniprot_information_type: SwissProt: Q8WXI2
uniprot_information:
Belongs to the CNKSR family &  Contains 1 CRIC domain &  Contains 1 DUF1170 domain &  Contains 1 PDZ (DHR) domain &  Contains 1 PH domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type: SwissProt: P17010
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily &  Contains 13 C2H2-type zinc fingers


uniprot_information_type: SwissProt: Q9GZU5
uniprot_information:
Belongs to the small leucine-rich proteoglycan (SLRP) family. Class IV subfamily &  Contains 11 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q8WWL7 # The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway (By similarity)# Belongs to the cyclin family. Cyclin AB subfamily

uniprot_information:
SwissProt: Q8WWL7 # The N-terminal destruction box (D-box) probably acts as a recognition signal for degradation via the ubiquitin-proteasome pathway (By similarity)# Belongs to the cyclin family. Cyclin AB subfamily


uniprot_information_type:
SwissProt: P10275 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA. The transcription factor activity of the complex formed by ligand-activated AR and DNA is modulated by interactions with coactivator and corepressor proteins. Interaction with RANBP9 is mediated by both the N-terminal domain and the DNA-binding domain. Interaction with EFCAB6/DJBP is mediated by the DNA-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P10275 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA. The transcription factor activity of the complex formed by ligand-activated AR and DNA is modulated by interactions with coactivator and corepressor proteins. Interaction with RANBP9 is mediated by both the N-terminal domain and the DNA-binding domain. Interaction with EFCAB6/DJBP is mediated by the DNA-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type: SwissProt: P21675
uniprot_information:
Belongs to the TAF1 family &  Contains 2 bromo domains &  Contains 1 HMG box DNA-binding domain &  Contains 2 protein kinase domains


uniprot_information_type:
SwissProt: Q96NX9 # The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain (By similarity)# Belongs to the DACH/dachshund family

uniprot_information:
SwissProt: Q96NX9 # The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain (By similarity)# Belongs to the DACH/dachshund family


uniprot_information_type:
SwissProt: P29400 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain

uniprot_information:
SwissProt: P29400 # Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain# Belongs to the type IV collagen family &  Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain


uniprot_information_type:
SwissProt: Q5JSL3 # The DHR-2 domain is necessary for the GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q5JSL3 # The DHR-2 domain is necessary for the GEF activity (By similarity)# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 PH domain


uniprot_information_type: SwissProt: Q9BQY4
uniprot_information:
Belongs to the paired-like homeobox family. PEPP subfamily &  Contains 1 homeobox DNA-binding domain


uniprot_information_type:
SwissProt: Q9ULC4 # The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly trough interaction with other proteins# Belongs to the MCTS1 family &  Contains 1 PUA domain

uniprot_information:
SwissProt: Q9ULC4 # The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function. MCT1 N-terminal region is required to enhance translation possibly trough interaction with other proteins# Belongs to the MCTS1 family &  Contains 1 PUA domain


uniprot_information_type:
SwissProt: P98170 # The first BIR domain is involved in interaction with TAB1/MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit caspase-3 and caspase-7, while the third BIR is involved in caspase-9 inhibition. The interactions with SMAC and PRSS25 are mediated by the second and third BIR domains# Belongs to the IAP family &  Contains 3 BIR repeats &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: P98170 # The first BIR domain is involved in interaction with TAB1/MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit caspase-3 and caspase-7, while the third BIR is involved in caspase-9 inhibition. The interactions with SMAC and PRSS25 are mediated by the second and third BIR domains# Belongs to the IAP family &  Contains 3 BIR repeats &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q9P289
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9UN88
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub-subfamily


uniprot_information_type:
SwissProt: O43610 # The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles# Belongs to the sprouty family &  Contains 1 SPR (sprouty) domain

uniprot_information:
SwissProt: O43610 # The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles# Belongs to the sprouty family &  Contains 1 SPR (sprouty) domain


uniprot_information_type:
SwissProt: Q99612 # The acidic N-terminal part may favor interaction with the basic domain of transcription factors# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 3 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q99612 # The acidic N-terminal part may favor interaction with the basic domain of transcription factors# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 3 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q8TC29 # Residues 160-255 contains the TRPC2 binding site (By similarity) &  The IQ motif is involved in calmodulin binding (By similarity)# Contains 1 IQ domain

uniprot_information:
SwissProt: Q8TC29 # Residues 160-255 contains the TRPC2 binding site (By similarity) &  The IQ motif is involved in calmodulin binding (By similarity)# Contains 1 IQ domain


uniprot_information_type: SwissProt: Q96TA2
uniprot_information:
In the N-terminal section; belongs to the AAA ATPase family &  In the C-terminal section; belongs to the peptidase M41 family


uniprot_information_type: SwissProt: Q5T2T1
uniprot_information:
Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 2 L27 domains &  Contains 1 PDZ (DHR) domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P33176 # Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles# Belongs to the kinesin-like protein family. Kinesin subfamily &  Contains 1 kinesin-motor domain

uniprot_information:
SwissProt: P33176 # Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles# Belongs to the kinesin-like protein family. Kinesin subfamily &  Contains 1 kinesin-motor domain


uniprot_information_type:
SwissProt: Q9H461 # The PDZ-binding motif mediates interaction with GOPC (By similarity) &  Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain

uniprot_information:
SwissProt: Q9H461 # The PDZ-binding motif mediates interaction with GOPC (By similarity) &  Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain


uniprot_information_type:
SwissProt: Q5T0T0 # The RING-CH-type zinc finger domain is required for E3 ligase activity# Contains 1 RING-CH-type zinc finger

uniprot_information:
SwissProt: Q5T0T0 # The RING-CH-type zinc finger domain is required for E3 ligase activity# Contains 1 RING-CH-type zinc finger


uniprot_information_type:
SwissProt: Q68DX3 # The FERM and PDZ 2 domains are necessary for localization to the basolateral cell membrane. The FERM domain binds to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and is sufficient for membrane localization# Contains 1 FERM domain &  Contains 1 KIND domain &  Contains 3 PDZ (DHR) domains

uniprot_information:
SwissProt: Q68DX3 # The FERM and PDZ 2 domains are necessary for localization to the basolateral cell membrane. The FERM domain binds to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and is sufficient for membrane localization# Contains 1 FERM domain &  Contains 1 KIND domain &  Contains 3 PDZ (DHR) domains


uniprot_information_type:
SwissProt: Q03468 # A C-terminal ubiquitin-binding domain (UBD) is essential for transcription-coupled nucleotide excision repair to proceed# Belongs to the SNF2/RAD54 helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain

uniprot_information:
SwissProt: Q03468 # A C-terminal ubiquitin-binding domain (UBD) is essential for transcription-coupled nucleotide excision repair to proceed# Belongs to the SNF2/RAD54 helicase family &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q16204 # The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation#

uniprot_information:
SwissProt: Q16204 # The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation#


uniprot_information_type:
SwissProt: Q15652 # Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity)# Belongs to the JHDM2 histone demethylase family &  Contains 1 JmjC domain

uniprot_information:
SwissProt: Q15652 # Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity)# Belongs to the JHDM2 histone demethylase family &  Contains 1 JmjC domain


uniprot_information_type:
SwissProt: P50995 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats

uniprot_information:
SwissProt: P50995 # A pair of annexin repeats may form one binding site for calcium and phospholipid# Belongs to the annexin family &  Contains 4 annexin repeats


uniprot_information_type:
SwissProt: Q8TE04 # The N-terminal extension, present in isoform 1 may be the regulatory domain# Belongs to the type II pantothenate kinase family

uniprot_information:
SwissProt: Q8TE04 # The N-terminal extension, present in isoform 1 may be the regulatory domain# Belongs to the type II pantothenate kinase family


uniprot_information_type: SwissProt: P54886
uniprot_information:
In the N-terminal section; belongs to the glutamate 5-kinase family &  In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family


uniprot_information_type:
SwissProt: Q6ZUJ8 # The DBB domain is required for dimerization (By similarity)# Contains 1 DBB domain

uniprot_information:
SwissProt: Q6ZUJ8 # The DBB domain is required for dimerization (By similarity)# Contains 1 DBB domain


uniprot_information_type:
SwissProt: Q9Y3B2 # The N- and C-terminal regions of the protein are required for interaction with RRP46# Contains 1 S1 motif domain

uniprot_information:
SwissProt: Q9Y3B2 # The N- and C-terminal regions of the protein are required for interaction with RRP46# Contains 1 S1 motif domain


uniprot_information_type:
SwissProt: Q5TCZ1 # The PX domain is required for podosome localization, and for binding phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2) &  The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19# Belongs to the SH3PXD2 family &  Contains 1 PX (phox homology) domain &  Contains 5 SH3 domains

uniprot_information:
SwissProt: Q5TCZ1 # The PX domain is required for podosome localization, and for binding phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2) &  The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19# Belongs to the SH3PXD2 family &  Contains 1 PX (phox homology) domain &  Contains 5 SH3 domains


uniprot_information_type:
SwissProt: Q9HCL2 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the GPAT/DAPAT family

uniprot_information:
SwissProt: Q9HCL2 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the GPAT/DAPAT family


uniprot_information_type:
SwissProt: Q9H5V7 # The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members &  C-terminal zinc fingers mediate homodimerization# Belongs to the Ikaros C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q9H5V7 # The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members &  C-terminal zinc fingers mediate homodimerization# Belongs to the Ikaros C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q8IU85 # The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q8IU85 # The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (By similarity)# Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q7L590 # The zinc finger-like domain binds a zinc ion and is involved in self-association (By similarity)# Belongs to the MCM10 family

uniprot_information:
SwissProt: Q7L590 # The zinc finger-like domain binds a zinc ion and is involved in self-association (By similarity)# Belongs to the MCM10 family


uniprot_information_type: SwissProt: Q8NEV4
uniprot_information:
In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family &  Contains 3 IQ domains &  Contains 1 myosin head-like domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q7Z5R6 # The two Pro-rich regions are required for the suppression of AP1 transcription activity# Belongs to the MRL family &  Contains 1 PH domain &  Contains 1 Ras-associating domain

uniprot_information:
SwissProt: Q7Z5R6 # The two Pro-rich regions are required for the suppression of AP1 transcription activity# Belongs to the MRL family &  Contains 1 PH domain &  Contains 1 Ras-associating domain


uniprot_information_type: SwissProt: Q96GX5
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P45983 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P45983 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9NR30 # The two enzymatic activities reside in two separate domains, the helicase in the N-terminus and the foldase in the C-terminus &  The 3 X 5 AA repeats seem to be critical for the RNA folding activity (By similarity)# Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain

uniprot_information:
SwissProt: Q9NR30 # The two enzymatic activities reside in two separate domains, the helicase in the N-terminus and the foldase in the C-terminus &  The 3 X 5 AA repeats seem to be critical for the RNA folding activity (By similarity)# Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q8WXS8 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix (By similarity)# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 4 TSP type-1 domains

uniprot_information:
SwissProt: Q8WXS8 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix (By similarity)# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 4 TSP type-1 domains


uniprot_information_type: SwissProt: Q8IZJ1
uniprot_information:
Belongs to the unc-5 family &  Contains 1 death domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 2 TSP type-1 domains &  Contains 1 ZU5 domain


uniprot_information_type:
SwissProt: Q9ULJ6 # The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein# Contains 1 SP-RING-type zinc finger

uniprot_information:
SwissProt: Q9ULJ6 # The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein# Contains 1 SP-RING-type zinc finger


uniprot_information_type:
SwissProt: P56975 # The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity) &  ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity)# Belongs to the neuregulin family &  Contains 1 EGF-like domain

uniprot_information:
SwissProt: P56975 # The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity) &  ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity)# Belongs to the neuregulin family &  Contains 1 EGF-like domain


uniprot_information_type:
SwissProt: P60484 # The C2 domain binds phospholipid membranes in vitro in a Ca(2+)-independent manner; this binding is important for its tumor suppressor function# Contains 1 C2 tensin-type domain &  Contains 1 phosphatase tensin-type domain

uniprot_information:
SwissProt: P60484 # The C2 domain binds phospholipid membranes in vitro in a Ca(2+)-independent manner; this binding is important for its tumor suppressor function# Contains 1 C2 tensin-type domain &  Contains 1 phosphatase tensin-type domain


uniprot_information_type:
SwissProt: Q96FJ0 # The JAMM motif is essential for the protease activity (By similarity)# Belongs to the peptidase M67C family &  Contains 1 MPN (JAB/Mov34) domain

uniprot_information:
SwissProt: Q96FJ0 # The JAMM motif is essential for the protease activity (By similarity)# Belongs to the peptidase M67C family &  Contains 1 MPN (JAB/Mov34) domain


uniprot_information_type: SwissProt: Q9H2K2
uniprot_information:
Contains 15 ANK repeats &  Contains 1 PARP catalytic domain &  Contains 1 SAM (sterile alpha motif) domain


uniprot_information_type:
SwissProt: Q9NX47 # The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-CH-type zinc finger

uniprot_information:
SwissProt: Q9NX47 # The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-CH-type zinc finger


uniprot_information_type:
SwissProt: Q969W1 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q969W1 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: Q9HB03 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the ELO family

uniprot_information:
SwissProt: Q9HB03 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the ELO family


uniprot_information_type:
SwissProt: Q9BZR9 # The coiled coil domain is required for homodimerization &  The region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1 (By similarity)# Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q9BZR9 # The coiled coil domain is required for homodimerization &  The region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1 (By similarity)# Belongs to the TRIM/RBCC family &  Contains 2 B box-type zinc fingers &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q9H4Y5
uniprot_information:
Belongs to the GST superfamily. Omega family &  Contains 1 GST C-terminal domain &  Contains 1 GST N-terminal domain


uniprot_information_type:
SwissProt: P08588 # The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor# Belongs to the G-protein coupled receptor 1 family. Adrenoceptor subfamily. ADRB1 sub-subfamily

uniprot_information:
SwissProt: P08588 # The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor# Belongs to the G-protein coupled receptor 1 family. Adrenoceptor subfamily. ADRB1 sub-subfamily


uniprot_information_type:
SwissProt: Q8WY41 # The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein (By similarity)# Belongs to the nanos family &  Contains 1 nanos-type zinc finger

uniprot_information:
SwissProt: Q8WY41 # The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein (By similarity)# Belongs to the nanos family &  Contains 1 nanos-type zinc finger


uniprot_information_type:
SwissProt: Q9HB21 # Binds to membranes enriched in PtdIns3,4P2 via the C-terminal PH domain# Contains 2 PH domains

uniprot_information:
SwissProt: Q9HB21 # Binds to membranes enriched in PtdIns3,4P2 via the C-terminal PH domain# Contains 2 PH domains


uniprot_information_type:
SwissProt: Q9UGI0 # The OTU domain mediates the deubiquitinating activity &  The RanBP2-type zinc fingers mediate the specific interaction with 'Lys-63'-linked ubiquitin# Belongs to the peptidase C64 family &  Contains 1 OTU domain &  Contains 3 RanBP2-type zinc fingers

uniprot_information:
SwissProt: Q9UGI0 # The OTU domain mediates the deubiquitinating activity &  The RanBP2-type zinc fingers mediate the specific interaction with 'Lys-63'-linked ubiquitin# Belongs to the peptidase C64 family &  Contains 1 OTU domain &  Contains 3 RanBP2-type zinc fingers


uniprot_information_type:
SwissProt: Q14185 # The DHR-2 domain is necessary and sufficient for the GEF activity# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q14185 # The DHR-2 domain is necessary and sufficient for the GEF activity# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: Q13202
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily &  Contains 1 rhodanese domain &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: Q9C035 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q9C035 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q12962 # The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase# Belongs to the TAF10 family

uniprot_information:
SwissProt: Q12962 # The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase# Belongs to the TAF10 family


uniprot_information_type: SwissProt: Q86WG5
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily &  Contains 1 dDENN domain &  Contains 1 DENN domain &  Contains 1 GRAM domain &  Contains 1 myotubularin phosphatase domain &  Contains 1 PH domain &  Contains 1 uDENN domain


uniprot_information_type: SwissProt: P78344
uniprot_information:
Belongs to the eIF4G family &  Contains 1 MI domain &  Contains 1 MIF4G domain &  Contains 1 W2 domain


uniprot_information_type: SwissProt: O00443
uniprot_information:
Belongs to the PI3/PI4-kinase family &  Contains 1 C2 domain &  Contains 1 PI3K/PI4K domain &  Contains 1 PX (phox homology) domain


uniprot_information_type: SwissProt: P54829
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: Q9NUP9 # The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane (By similarity) &  The PDZ domain regulates endocytosis and recycling of the receptor at the membrane (By similarity) &  The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes (By similarity)# Belongs to the lin-7 family &  Contains 1 L27 domain &  Contains 1 PDZ (DHR) domain

uniprot_information:
SwissProt: Q9NUP9 # The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane (By similarity) &  The PDZ domain regulates endocytosis and recycling of the receptor at the membrane (By similarity) &  The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes (By similarity)# Belongs to the lin-7 family &  Contains 1 L27 domain &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: Q9HCJ2 # The LRR region is both necessary and sufficient for the interaction with NTNG1# Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 9 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q9HCJ2 # The LRR region is both necessary and sufficient for the interaction with NTNG1# Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 9 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q7L8C5 # The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding (By similarity) &  The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present (By similarity)# Belongs to the synaptotagmin family &  Contains 2 C2 domains

uniprot_information:
SwissProt: Q7L8C5 # The first C2 domain/C2A does not mediate Ca(2+)-dependent phospholipid binding (By similarity) &  The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present (By similarity)# Belongs to the synaptotagmin family &  Contains 2 C2 domains


uniprot_information_type:
SwissProt: Q8N3X1 # These WW domains interact with Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (WBPs). The N-terminal WW domain has the greater ligand-binding ability (By similarity)# Contains 2 WW domains

uniprot_information:
SwissProt: Q8N3X1 # These WW domains interact with Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (WBPs). The N-terminal WW domain has the greater ligand-binding ability (By similarity)# Contains 2 WW domains


uniprot_information_type:
SwissProt: O43581 # The second C2 domain/C2B is responsible for SYNCRIP binding (By similarity)# Belongs to the synaptotagmin family &  Contains 2 C2 domains

uniprot_information:
SwissProt: O43581 # The second C2 domain/C2B is responsible for SYNCRIP binding (By similarity)# Belongs to the synaptotagmin family &  Contains 2 C2 domains


uniprot_information_type:
SwissProt: Q92934 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family# Belongs to the Bcl-2 family

uniprot_information:
SwissProt: Q92934 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family# Belongs to the Bcl-2 family


uniprot_information_type:
SwissProt: Q96FF9 # The KEN box is required for the association with the APC/C complex (By similarity)#

uniprot_information:
SwissProt: Q96FF9 # The KEN box is required for the association with the APC/C complex (By similarity)#


uniprot_information_type:
SwissProt: Q86TM6 # The RING-type zinc finger is required for E3 ligase activity# Belongs to the HRD1 family &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q86TM6 # The RING-type zinc finger is required for E3 ligase activity# Belongs to the HRD1 family &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9NS15 # Associates covalently with small latent TGF-beta complex via Repeat C# Belongs to the LTBP family &  Contains 13 EGF-like domains &  Contains 4 TB (TGF-beta binding) domains

uniprot_information:
SwissProt: Q9NS15 # Associates covalently with small latent TGF-beta complex via Repeat C# Belongs to the LTBP family &  Contains 13 EGF-like domains &  Contains 4 TB (TGF-beta binding) domains


uniprot_information_type:
SwissProt: Q6UX98 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q6UX98 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type: SwissProt: Q4FZB7
uniprot_information:
Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily &  Contains 1 SET domain


uniprot_information_type:
SwissProt: Q9UPX8 # The PDZ domain is required for interaction with GRID2, PLCB3, CFTR and SLC9A3 (By similarity)# Belongs to the SHANK family &  Contains 1 PDZ (DHR) domain &  Contains 1 SAM (sterile alpha motif) domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q9UPX8 # The PDZ domain is required for interaction with GRID2, PLCB3, CFTR and SLC9A3 (By similarity)# Belongs to the SHANK family &  Contains 1 PDZ (DHR) domain &  Contains 1 SAM (sterile alpha motif) domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P49407 # The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1 (By similarity). Binding to phosphorylated GPCRs induces a conformationanl change that exposes the motif to the surface &  The N-terminus binds InsP6 with low affinity (By similarity) &  The C-terminus binds InsP6 with high affinity (By similarity)# Belongs to the arrestin family

uniprot_information:
SwissProt: P49407 # The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1 (By similarity). Binding to phosphorylated GPCRs induces a conformationanl change that exposes the motif to the surface &  The N-terminus binds InsP6 with low affinity (By similarity) &  The C-terminus binds InsP6 with high affinity (By similarity)# Belongs to the arrestin family


uniprot_information_type: SwissProt: Q13153
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 CRIB domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q15700 # Isoform 2 has an L27 domain close to N-terminus# Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 3 PDZ (DHR) domains &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q15700 # Isoform 2 has an L27 domain close to N-terminus# Belongs to the MAGUK family &  Contains 1 guanylate kinase-like domain &  Contains 3 PDZ (DHR) domains &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q9HCH5 # The RabBD domain mediates interaction with RAB27A and recruitment on to vesicular structures in cytotoxic T-lymphocytes (CTL) &  The C2 1 domain mediates binding to phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and localization to the cell membrane# Contains 2 C2 domains &  Contains 1 RabBD (Rab-binding) domain

uniprot_information:
SwissProt: Q9HCH5 # The RabBD domain mediates interaction with RAB27A and recruitment on to vesicular structures in cytotoxic T-lymphocytes (CTL) &  The C2 1 domain mediates binding to phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and localization to the cell membrane# Contains 2 C2 domains &  Contains 1 RabBD (Rab-binding) domain


uniprot_information_type:
SwissProt: Q9ULV1 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain

uniprot_information:
SwissProt: Q9ULV1 # Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity) &  The FZ domain is involved in binding with Wnt ligands (By similarity)# Belongs to the G-protein coupled receptor Fz/Smo family &  Contains 1 FZ (frizzled) domain


uniprot_information_type:
SwissProt: Q8IZL2 # The C-terminal domain is required for transcriptional activation# Belongs to the mastermind family

uniprot_information:
SwissProt: Q8IZL2 # The C-terminal domain is required for transcriptional activation# Belongs to the mastermind family


uniprot_information_type:
SwissProt: P06401 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain

uniprot_information:
SwissProt: P06401 # Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain# Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type:
SwissProt: P22894 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: P22894 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type: SwissProt: Q96BT7
uniprot_information:
Belongs to the alkB family &  Contains 1 Fe2OG dioxygenase domain &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: P35241 # The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ablilty to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN (By similarity)# Contains 1 FERM domain

uniprot_information:
SwissProt: P35241 # The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ablilty to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN (By similarity)# Contains 1 FERM domain


uniprot_information_type:
SwissProt: Q9Y5J9 # The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity)# Belongs to the small Tim family

uniprot_information:
SwissProt: Q9Y5J9 # The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity)# Belongs to the small Tim family


uniprot_information_type: SwissProt: Q96RU2
uniprot_information:
Belongs to the peptidase C19 family. USP28 subfamily &  Contains 1 UIM (ubiquitin-interacting motif) repeat


uniprot_information_type:
SwissProt: Q9BY67 # The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC# Belongs to the nectin family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q9BY67 # The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC# Belongs to the nectin family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: P56817 # The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP# Belongs to the peptidase A1 family

uniprot_information:
SwissProt: P56817 # The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP# Belongs to the peptidase A1 family


uniprot_information_type: SwissProt: Q8TD84
uniprot_information:
Contains 6 fibronectin type-III domains &  Contains 10 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q9BYE2
uniprot_information:
Belongs to the peptidase S1 family &  Contains 1 LDL-receptor class A domain &  Contains 1 peptidase S1 domain &  Contains 1 SRCR domain


uniprot_information_type: SwissProt: Q8IWT1
uniprot_information:
Belongs to the sodium channel auxiliary subunit SCN4B (TC 8.A.17) family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: O60939
uniprot_information:
Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q86YT9 # The Ig-like V-type domain 2 mediates interaction with CXADR# Belongs to the immunoglobulin superfamily &  Contains 2 Ig-like V-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: Q86YT9 # The Ig-like V-type domain 2 mediates interaction with CXADR# Belongs to the immunoglobulin superfamily &  Contains 2 Ig-like V-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: P26196
uniprot_information:
Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q86UU0 # Tne C-terminal domain is important for its transactivation activity (By similarity)# Belongs to the BCL9 family

uniprot_information:
SwissProt: Q86UU0 # Tne C-terminal domain is important for its transactivation activity (By similarity)# Belongs to the BCL9 family


uniprot_information_type: SwissProt: Q9BY79
uniprot_information:
Contains 2 CUB domains &  Contains 1 FZ (frizzled) domain &  Contains 2 LDL-receptor class A domains


uniprot_information_type:
SwissProt: O75604 # The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity (By similarity)# Belongs to the peptidase C19 family. USP2 subfamily

uniprot_information:
SwissProt: O75604 # The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity (By similarity)# Belongs to the peptidase C19 family. USP2 subfamily


uniprot_information_type: SwissProt: Q8WZ75
uniprot_information:
Belongs to the immunoglobulin superfamily. ROBO family &  Contains 2 fibronectin type-III domains &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q14CZ8 # The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility# Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain

uniprot_information:
SwissProt: Q14CZ8 # The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility# Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: A7KAX9 # The N-terminal PX domain interacts specifically with phosphatidylinositides (By similarity)# Belongs to the PX domain-containing GAP family &  Contains 1 PX (phox homology) domain &  Contains 1 Rho-GAP domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: A7KAX9 # The N-terminal PX domain interacts specifically with phosphatidylinositides (By similarity)# Belongs to the PX domain-containing GAP family &  Contains 1 PX (phox homology) domain &  Contains 1 Rho-GAP domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q9UP79 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 2 TSP type-1 domains

uniprot_information:
SwissProt: Q9UP79 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 2 TSP type-1 domains


uniprot_information_type: SwissProt: Q8IWQ3
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P48547 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily

uniprot_information:
SwissProt: P48547 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily


uniprot_information_type:
SwissProt: Q9NZC4 # The PNT domain acts as a transcriptional activator (By similarity)# Belongs to the ETS family &  Contains 1 ETS DNA-binding domain &  Contains 1 PNT (pointed) domain

uniprot_information:
SwissProt: Q9NZC4 # The PNT domain acts as a transcriptional activator (By similarity)# Belongs to the ETS family &  Contains 1 ETS DNA-binding domain &  Contains 1 PNT (pointed) domain


uniprot_information_type: SwissProt: Q12913
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily &  Contains 9 fibronectin type-III domains &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: Q9C0B5 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q9C0B5 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: P60852 # The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida# Belongs to the ZP domain family. ZPB subfamily &  Contains 1 P-type (trefoil) domain &  Contains 1 ZP domain

uniprot_information:
SwissProt: P60852 # The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida# Belongs to the ZP domain family. ZPB subfamily &  Contains 1 P-type (trefoil) domain &  Contains 1 ZP domain


uniprot_information_type: SwissProt: Q3LXA3
uniprot_information:
Belongs to the dihydroxyacetone kinase (DAK) family &  Contains 1 DhaK domain &  Contains 1 DhaL domain


uniprot_information_type:
SwissProt: O95864 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the fatty acid desaturase family &  Contains 1 cytochrome b5 heme-binding domain

uniprot_information:
SwissProt: O95864 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the fatty acid desaturase family &  Contains 1 cytochrome b5 heme-binding domain


uniprot_information_type:
SwissProt: Q96DT0 # Contains two homologous but distinct carbohydrate-binding domains# Contains 2 galectin domains

uniprot_information:
SwissProt: Q96DT0 # Contains two homologous but distinct carbohydrate-binding domains# Contains 2 galectin domains


uniprot_information_type:
SwissProt: Q86UX7 # The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain# Belongs to the kindlin family &  Contains 1 FERM domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q86UX7 # The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain# Belongs to the kindlin family &  Contains 1 FERM domain &  Contains 1 PH domain


uniprot_information_type: SwissProt: P07384
uniprot_information:
Belongs to the peptidase C2 family &  Contains 1 calpain catalytic domain &  Contains 4 EF-hand domains


uniprot_information_type:
SwissProt: Q96KG9 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily &  Contains 3 HEAT repeats &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q96KG9 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily &  Contains 3 HEAT repeats &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8NHX9 # Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily

uniprot_information:
SwissProt: Q8NHX9 # Each of the two internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position (By similarity)# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily


uniprot_information_type:
SwissProt: Q8NBQ7 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily

uniprot_information:
SwissProt: Q8NBQ7 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily


uniprot_information_type:
SwissProt: Q6UX15 # The C-terminal domain interacts with the N-terminal domain of RDX (By similarity)# Contains 1 C-type lectin domain

uniprot_information:
SwissProt: Q6UX15 # The C-terminal domain interacts with the N-terminal domain of RDX (By similarity)# Contains 1 C-type lectin domain


uniprot_information_type: SwissProt: Q9H0K1
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily &  Contains 1 protein kinase domain &  Contains 1 UBA domain


uniprot_information_type: SwissProt: P68402
uniprot_information:
Belongs to the 'GDSL' lipolytic enzyme family. Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily


uniprot_information_type: SwissProt: Q01995
uniprot_information:
Belongs to the calponin family &  Contains 1 calponin-like repeat &  Contains 1 CH (calponin-homology) domain


uniprot_information_type:
SwissProt: P22681 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme &  The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain# Contains 1 CBL N-terminal domain &  Contains 2 EF-hand-like domains &  Contains 1 RING-type zinc finger &  Contains 1 SH2 domain &  Contains 1 UBA domain

uniprot_information:
SwissProt: P22681 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme &  The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain# Contains 1 CBL N-terminal domain &  Contains 2 EF-hand-like domains &  Contains 1 RING-type zinc finger &  Contains 1 SH2 domain &  Contains 1 UBA domain


uniprot_information_type:
SwissProt: O75443 # Zona pellucida domain may enable to form filaments# Contains 1 NIDO domain &  Contains 3 TIL (trypsin inhibitory-like) domains &  Contains 1 VWFC domain &  Contains 4 VWFD domains &  Contains 1 ZP domain

uniprot_information:
SwissProt: O75443 # Zona pellucida domain may enable to form filaments# Contains 1 NIDO domain &  Contains 3 TIL (trypsin inhibitory-like) domains &  Contains 1 VWFC domain &  Contains 4 VWFD domains &  Contains 1 ZP domain


uniprot_information_type: SwissProt: Q3YBR2
uniprot_information:
Belongs to the TBRG1 family &  Contains 1 FY-rich C-terminal domain &  Contains 1 FY-rich N-terminal domain


uniprot_information_type:
SwissProt: Q8TE58 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix (By similarity) &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 3 TSP type-1 domains

uniprot_information:
SwissProt: Q8TE58 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix (By similarity) &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 3 TSP type-1 domains


uniprot_information_type: SwissProt: Q9BX67
uniprot_information:
Belongs to the immunoglobulin superfamily &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: P29375 # The GSGFP motif is required for the interaction with SUZ12 (By similarity)# Belongs to the JARID1 histone demethylase family &  Contains 1 ARID domain &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 3 PHD-type zinc fingers

uniprot_information:
SwissProt: P29375 # The GSGFP motif is required for the interaction with SUZ12 (By similarity)# Belongs to the JARID1 histone demethylase family &  Contains 1 ARID domain &  Contains 1 JmjC domain &  Contains 1 JmjN domain &  Contains 3 PHD-type zinc fingers


uniprot_information_type:
SwissProt: Q7Z3S7 # The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch (By similarity)# Belongs to the calcium channel subunit alpha-2/delta family &  Contains 1 cache domain &  Contains 1 VWFA domain

uniprot_information:
SwissProt: Q7Z3S7 # The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch (By similarity)# Belongs to the calcium channel subunit alpha-2/delta family &  Contains 1 cache domain &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: P04275 # The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules# Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 4 TIL (trypsin inhibitory-like) domains &  Contains 3 VWFA domains &  Contains 3 VWFC domains &  Contains 4 VWFD domains

uniprot_information:
SwissProt: P04275 # The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules# Contains 1 CTCK (C-terminal cystine knot-like) domain &  Contains 4 TIL (trypsin inhibitory-like) domains &  Contains 3 VWFA domains &  Contains 3 VWFC domains &  Contains 4 VWFD domains


uniprot_information_type:
SwissProt: Q99618 # The KEN box is required for the association with the APC/C-Cdh1 complex (By similarity)#

uniprot_information:
SwissProt: Q99618 # The KEN box is required for the association with the APC/C-Cdh1 complex (By similarity)#


uniprot_information_type:
SwissProt: Q99619 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the SPSB family &  Contains 1 B30.2/SPRY domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q99619 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the SPSB family &  Contains 1 B30.2/SPRY domain &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: P82980 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family

uniprot_information:
SwissProt: P82980 # Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior# Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family


uniprot_information_type:
SwissProt: O75581 # The YWTD-EGF-like domains 1 and 2 are required for the interaction with Wnt-frizzled complex. The YWTD-EGF-like domains 3 and 4 are required for the interaction with DKK1 &  The PPPSP motifs play a central role in signal transduction by being phosphorylated, leading to activate the Wnt signaling pathway# Belongs to the LDLR family &  Contains 4 EGF-like domains &  Contains 3 LDL-receptor class A domains &  Contains 20 LDL-receptor class B repeats

uniprot_information:
SwissProt: O75581 # The YWTD-EGF-like domains 1 and 2 are required for the interaction with Wnt-frizzled complex. The YWTD-EGF-like domains 3 and 4 are required for the interaction with DKK1 &  The PPPSP motifs play a central role in signal transduction by being phosphorylated, leading to activate the Wnt signaling pathway# Belongs to the LDLR family &  Contains 4 EGF-like domains &  Contains 3 LDL-receptor class A domains &  Contains 20 LDL-receptor class B repeats


uniprot_information_type:
SwissProt: Q86YW0 # The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity (By similarity) &  The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization (By similarity)# Contains 1 C2 domain &  Contains 1 EF-hand domain &  Contains 1 PI-PLC X-box domain &  Contains 1 PI-PLC Y-box domain

uniprot_information:
SwissProt: Q86YW0 # The EF-hand and C2 domains are essential for triggering Ca(2+) oscillating activity and the regulation of PLCZ1 enzyme activity (By similarity) &  The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization (By similarity)# Contains 1 C2 domain &  Contains 1 EF-hand domain &  Contains 1 PI-PLC X-box domain &  Contains 1 PI-PLC Y-box domain


uniprot_information_type: SwissProt: Q6ZUT9
uniprot_information:
Belongs to the RAB6IP1 family &  Contains 1 dDENN domain &  Contains 1 DENN domain &  Contains 1 PLAT domain &  Contains 2 RUN domains &  Contains 1 uDENN domain


uniprot_information_type: SwissProt: Q7Z4S6
uniprot_information:
Belongs to the kinesin-like protein family &  Contains 1 kinesin-motor domain &  Contains 7 WD repeats


uniprot_information_type:
SwissProt: Q8WUI4 # The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm (By similarity)# Belongs to the histone deacetylase family. Type 2 subfamily

uniprot_information:
SwissProt: Q8WUI4 # The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm (By similarity)# Belongs to the histone deacetylase family. Type 2 subfamily


uniprot_information_type:
SwissProt: Q9H765 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 4 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q9H765 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 4 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q96N77
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: O14686 # LXXLL motifs 5 and 5 are essential for the association with ESR1 nuclear receptor# Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily &  Contains 5 PHD-type zinc fingers &  Contains 1 post-SET domain &  Contains 1 RING-type zinc finger &  Contains 1 SET domain

uniprot_information:
SwissProt: O14686 # LXXLL motifs 5 and 5 are essential for the association with ESR1 nuclear receptor# Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily &  Contains 5 PHD-type zinc fingers &  Contains 1 post-SET domain &  Contains 1 RING-type zinc finger &  Contains 1 SET domain


uniprot_information_type: SwissProt: Q8IVF7
uniprot_information:
Belongs to the formin homology family &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


uniprot_information_type:
SwissProt: Q9UHB6 # Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus# Contains 1 LIM zinc-binding domain

uniprot_information:
SwissProt: Q9UHB6 # Contains at least 2 actin-binding domains, one on each side of the LIM domain. Both domains bind actin monomers and filaments. The C-terminal domain binds filaments more efficiently than the N-terminus# Contains 1 LIM zinc-binding domain


uniprot_information_type: SwissProt: Q14863
uniprot_information:
Belongs to the POU transcription factor family. Class-6 subfamily &  Contains 1 homeobox DNA-binding domain &  Contains 1 POU-specific domain


uniprot_information_type:
SwissProt: Q8NCL4 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q8NCL4 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: Q9BRP8 # The eIF2A-like region shares sequence similarity with eIF2A and mediates the interaction with the 40S ribosomal subunit and the 48S preinitiation complex# Belongs to the wibg family

uniprot_information:
SwissProt: Q9BRP8 # The eIF2A-like region shares sequence similarity with eIF2A and mediates the interaction with the 40S ribosomal subunit and the 48S preinitiation complex# Belongs to the wibg family


uniprot_information_type: SwissProt: O75366
uniprot_information:
Belongs to the villin/gelsolin family &  Contains 6 gelsolin-like repeats &  Contains 1 HP (headpiece) domain


uniprot_information_type:
SwissProt: Q9Y3R0 # PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1 and EPHB2 and with the C-terminus of PPFIA1 and PPFIA4. PDZ 4 and PDZ 5 mediate interaction with the C-terminus of GRIA2 and GRIA3. PDZ 4, PDZ 5 and PDZ 6 mediate homomultimers. PDZ 7 mediates interaction with PDZ domain of GRASP1. PDZ 7 domain binds CSPG4. PDZ 6 mediates interaction with the C-terminus of liprins-alpha. PDZ 1, PDZ 2 and PDZ 3 mediate interaction with the PDZ-binding motif of FRAS1 (By similarity). PDZ 4 and PDZ 5 mediate interaction with PRLHR# Contains 7 PDZ (DHR) domains

uniprot_information:
SwissProt: Q9Y3R0 # PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1 and EPHB2 and with the C-terminus of PPFIA1 and PPFIA4. PDZ 4 and PDZ 5 mediate interaction with the C-terminus of GRIA2 and GRIA3. PDZ 4, PDZ 5 and PDZ 6 mediate homomultimers. PDZ 7 mediates interaction with PDZ domain of GRASP1. PDZ 7 domain binds CSPG4. PDZ 6 mediates interaction with the C-terminus of liprins-alpha. PDZ 1, PDZ 2 and PDZ 3 mediate interaction with the PDZ-binding motif of FRAS1 (By similarity). PDZ 4 and PDZ 5 mediate interaction with PRLHR# Contains 7 PDZ (DHR) domains


uniprot_information_type: SwissProt: P23467
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily &  Contains 17 fibronectin type-III domains &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: Q96PR1 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily

uniprot_information:
SwissProt: Q96PR1 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily


uniprot_information_type:
SwissProt: Q96AV8 # Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer# Belongs to the E2F/DP family

uniprot_information:
SwissProt: Q96AV8 # Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer# Belongs to the E2F/DP family


uniprot_information_type:
SwissProt: Q8N4A0 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q8N4A0 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: Q15075 # The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate# Contains 1 C2H2-type zinc finger &  Contains 1 FYVE-type zinc finger

uniprot_information:
SwissProt: Q15075 # The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate# Contains 1 C2H2-type zinc finger &  Contains 1 FYVE-type zinc finger


uniprot_information_type: SwissProt: Q9HB63
uniprot_information:
Contains 3 laminin EGF-like domains &  Contains 1 laminin N-terminal domain &  Contains 1 NTR domain


uniprot_information_type: SwissProt: Q3SY69
uniprot_information:
In the N-terminal section; belongs to the GART family &  In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily &  Contains 1 acyl carrier domain


uniprot_information_type:
SwissProt: Q96D96 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain# Belongs to the hydrogen channel family

uniprot_information:
SwissProt: Q96D96 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain# Belongs to the hydrogen channel family


uniprot_information_type: SwissProt: Q8TDD1
uniprot_information:
Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: P29475 # The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles. Mediates interaction with VAC14 (By similarity)# Belongs to the NOS family &  Contains 1 FAD-binding FR-type domain &  Contains 1 flavodoxin-like domain &  Contains 1 PDZ (DHR) domain

uniprot_information:
SwissProt: P29475 # The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles. Mediates interaction with VAC14 (By similarity)# Belongs to the NOS family &  Contains 1 FAD-binding FR-type domain &  Contains 1 flavodoxin-like domain &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: Q6VAB6 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q6VAB6 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8NHM5 # The JmjC domain mediates demethylation activity (By similarity). It is also required for repression of ribosomal RNA genes# Belongs to the JHDM1 histone demethylase family &  Contains 1 CXXC-type zinc finger &  Contains 1 F-box domain &  Contains 1 JmjC domain &  Contains 4 LRR (leucine-rich) repeats &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: Q8NHM5 # The JmjC domain mediates demethylation activity (By similarity). It is also required for repression of ribosomal RNA genes# Belongs to the JHDM1 histone demethylase family &  Contains 1 CXXC-type zinc finger &  Contains 1 F-box domain &  Contains 1 JmjC domain &  Contains 4 LRR (leucine-rich) repeats &  Contains 1 PHD-type zinc finger


uniprot_information_type:
SwissProt: O15034 # The SH3 domains mediate binding to a proline-rich motif in RIMS1, RIMS2, CACNA1D and CACNA1B (By similarity)# Belongs to the RIMBP family &  Contains 3 fibronectin type-III domains &  Contains 3 SH3 domains

uniprot_information:
SwissProt: O15034 # The SH3 domains mediate binding to a proline-rich motif in RIMS1, RIMS2, CACNA1D and CACNA1B (By similarity)# Belongs to the RIMBP family &  Contains 3 fibronectin type-III domains &  Contains 3 SH3 domains


uniprot_information_type:
SwissProt: Q9HCQ5 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q9HCQ5 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: Q96EP1 # The PBZ-type zinc finger (also named CYR) mediates non-covalent poly(ADP-ribose)-binding. Poly(ADP-ribose)-binding is dependent on the presence of zinc and is required for its function in antephase checkpoint &  The FHA domain plays a key role in the anti-proliferative properties of the protein and is involved in initiating a cell cycle arrest at G2/M. The FHA domain may be required to interact with phosphorylated proteins# Belongs to the CHFR family &  Contains 1 FHA domain &  Contains 1 PBZ-type zinc finger &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q96EP1 # The PBZ-type zinc finger (also named CYR) mediates non-covalent poly(ADP-ribose)-binding. Poly(ADP-ribose)-binding is dependent on the presence of zinc and is required for its function in antephase checkpoint &  The FHA domain plays a key role in the anti-proliferative properties of the protein and is involved in initiating a cell cycle arrest at G2/M. The FHA domain may be required to interact with phosphorylated proteins# Belongs to the CHFR family &  Contains 1 FHA domain &  Contains 1 PBZ-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q86T29
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 17 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q13936 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position &  Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel (By similarity)# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily

uniprot_information:
SwissProt: Q13936 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position &  Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel (By similarity)# Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily


uniprot_information_type:
SwissProt: Q9NR22 # The SH3-binding motifs mediate the interaction with SH3 domain-containing proteins such as PRMT2 and FYN, possibly leading to displace the N-terminal domain and activate the protein &  The N-terminal region (1-60) inhibits the enzymatic activity# Belongs to the protein arginine N-methyltransferase family. PRMT8 subfamily

uniprot_information:
SwissProt: Q9NR22 # The SH3-binding motifs mediate the interaction with SH3 domain-containing proteins such as PRMT2 and FYN, possibly leading to displace the N-terminal domain and activate the protein &  The N-terminal region (1-60) inhibits the enzymatic activity# Belongs to the protein arginine N-methyltransferase family. PRMT8 subfamily


uniprot_information_type:
SwissProt: Q09470 # The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments &  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily

uniprot_information:
SwissProt: Q09470 # The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments &  The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily


uniprot_information_type:
SwissProt: Q2HXU8 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 1 C-type lectin domain

uniprot_information:
SwissProt: Q2HXU8 # Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases# Contains 1 C-type lectin domain


uniprot_information_type: SwissProt: Q96FC9
uniprot_information:
Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily &  Contains 1 helicase ATP-binding domain


uniprot_information_type:
SwissProt: Q96M96 # The part of the protein spanning the actin filament-binding domain together with the DH domain and the first PH domain is necessary and sufficient for microspike formation. Activation of MAPK8 requires the presence of all domains with the exception of the actin filament-binding domain (By similarity)# Contains 1 DH (DBL-homology) domain &  Contains 1 FYVE-type zinc finger &  Contains 2 PH domains

uniprot_information:
SwissProt: Q96M96 # The part of the protein spanning the actin filament-binding domain together with the DH domain and the first PH domain is necessary and sufficient for microspike formation. Activation of MAPK8 requires the presence of all domains with the exception of the actin filament-binding domain (By similarity)# Contains 1 DH (DBL-homology) domain &  Contains 1 FYVE-type zinc finger &  Contains 2 PH domains


