# uniprot

uniprot_information_type: SwissProt: Q5S007
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 16 LRR (leucine-rich) repeats &  Contains 1 protein kinase domain &  Contains 1 Roc domain


uniprot_information_type:
SwissProt: Q9ULD8 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily &  Contains 1 cyclic nucleotide-binding domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain

uniprot_information:
SwissProt: Q9ULD8 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily &  Contains 1 cyclic nucleotide-binding domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain


uniprot_information_type:
SwissProt: P41181 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family

uniprot_information:
SwissProt: P41181 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family


uniprot_information_type:
SwissProt: Q9H2S9 # The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members &  C-terminal zinc fingers mediate homodimerization# Belongs to the Ikaros C2H2-type zinc-finger protein family &  Contains 6 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q9H2S9 # The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members &  C-terminal zinc fingers mediate homodimerization# Belongs to the Ikaros C2H2-type zinc-finger protein family &  Contains 6 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: P21860 # The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins# Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P21860 # The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins# Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q12840 # Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles# Belongs to the kinesin-like protein family. Kinesin subfamily &  Contains 1 kinesin-motor domain

uniprot_information:
SwissProt: Q12840 # Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles# Belongs to the kinesin-like protein family. Kinesin subfamily &  Contains 1 kinesin-motor domain


uniprot_information_type:
SwissProt: Q86VW2 # The guanine nucleotide exchange activity is autoinhibited by the PH domain# Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q86VW2 # The guanine nucleotide exchange activity is autoinhibited by the PH domain# Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q86YJ5 # The RING-CH-type zinc finger domain is required for E3 ligase activity# Contains 1 RING-CH-type zinc finger

uniprot_information:
SwissProt: Q86YJ5 # The RING-CH-type zinc finger domain is required for E3 ligase activity# Contains 1 RING-CH-type zinc finger


uniprot_information_type:
SwissProt: Q00987 # Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73 and E2F1. Region II contains most of a central acidic region required for interaction with ribosomal protein L5 and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc interacts specifically with RNA whether or not zinc is present and mediates the heterooligomerization with MDM4. It is also essential for its ubiquitin ligase E3 activity toward p53 and itself# Belongs to the MDM2/MDM4 family &  Contains 1 RanBP2-type zinc finger &  Contains 1 RING-type zinc finger &  Contains 1 SWIB domain

uniprot_information:
SwissProt: Q00987 # Region I is sufficient for binding p53 and inhibiting its G1 arrest and apoptosis functions. It also binds p73 and E2F1. Region II contains most of a central acidic region required for interaction with ribosomal protein L5 and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc interacts specifically with RNA whether or not zinc is present and mediates the heterooligomerization with MDM4. It is also essential for its ubiquitin ligase E3 activity toward p53 and itself# Belongs to the MDM2/MDM4 family &  Contains 1 RanBP2-type zinc finger &  Contains 1 RING-type zinc finger &  Contains 1 SWIB domain


uniprot_information_type:
SwissProt: Q86W47 # Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain# Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily

uniprot_information:
SwissProt: Q86W47 # Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain# Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 subfamily


uniprot_information_type:
SwissProt: P42166 # The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1 &  The C-terminal domain forms a four-stranded coiled coil (By similarity)# Belongs to the LEM family &  Contains 1 LEM domain &  Contains 1 LEM-like domain

uniprot_information:
SwissProt: P42166 # The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1 &  The C-terminal domain forms a four-stranded coiled coil (By similarity)# Belongs to the LEM family &  Contains 1 LEM domain &  Contains 1 LEM-like domain


uniprot_information_type:
P42167 # Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1# Belongs to the LEM family &  Contains 1 LEM domain &  Contains 1 LEM-like domain

uniprot_information:
P42167 # Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1# Belongs to the LEM family &  Contains 1 LEM domain &  Contains 1 LEM-like domain


uniprot_information_type: SwissProt: Q6P3W7
uniprot_information:
Belongs to the protein kinase superfamily &  Contains 1 HEAT repeat &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8WWQ8 # Recognizes phosphatidyl serine via its epidermal growth factor-like domains# Contains 17 EGF-like domains &  Contains 7 FAS1 domains &  Contains 2 laminin EGF-like domains &  Contains 1 Link domain

uniprot_information:
SwissProt: Q8WWQ8 # Recognizes phosphatidyl serine via its epidermal growth factor-like domains# Contains 17 EGF-like domains &  Contains 7 FAS1 domains &  Contains 2 laminin EGF-like domains &  Contains 1 Link domain


uniprot_information_type:
SwissProt: Q86Y01 # The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases (By similarity)# Belongs to the Deltex family &  Contains 1 RING-type zinc finger &  Contains 2 WWE domains

uniprot_information:
SwissProt: Q86Y01 # The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases (By similarity)# Belongs to the Deltex family &  Contains 1 RING-type zinc finger &  Contains 2 WWE domains


uniprot_information_type:
SwissProt: Q9H7L9 # The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms# Belongs to the SDS3 family

uniprot_information:
SwissProt: Q9H7L9 # The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms# Belongs to the SDS3 family


uniprot_information_type:
SwissProt: Q9NQR1 # Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity# Belongs to the histone-lysine methyltransferase family. PR/SET subfamily &  Contains 1 SET domain

uniprot_information:
SwissProt: Q9NQR1 # Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity# Belongs to the histone-lysine methyltransferase family. PR/SET subfamily &  Contains 1 SET domain


uniprot_information_type:
SwissProt: Q8NHQ9 # The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis# Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain

uniprot_information:
SwissProt: Q8NHQ9 # The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis# Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q8IVF4 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family &  Contains 16 LRR (leucine-rich) repeats &  Contains 5 TPR repeats

uniprot_information:
SwissProt: Q8IVF4 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family &  Contains 16 LRR (leucine-rich) repeats &  Contains 5 TPR repeats


uniprot_information_type: SwissProt: Q96L91
uniprot_information:
Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 HSA domain &  Contains 1 Myb-like domain


uniprot_information_type: SwissProt: Q14587
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 24 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: Q9NRM7
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain &  Contains 1 UBA domain


uniprot_information_type:
SwissProt: Q5W0Z9 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q5W0Z9 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: Q8N448 # The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient# Contains 4 PDZ (DHR) domains &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8N448 # The NPXY motif is required for the interaction with the PID domain of NUMB. It is however not sufficient# Contains 4 PDZ (DHR) domains &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: P17948
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily &  Contains 7 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: O15075
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily &  Contains 2 doublecortin domains &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9UBN4 # The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation &  The calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) domain (695-724) is sufficient for the interaction with SESTD1 &  The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5# Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily &  Contains 2 ANK repeats

uniprot_information:
SwissProt: Q9UBN4 # The protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation &  The calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) domain (695-724) is sufficient for the interaction with SESTD1 &  The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5# Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily &  Contains 2 ANK repeats


uniprot_information_type:
SwissProt: Q86VN1 # The GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates the binding to ubiquitin and phosphoinosides# Belongs to the VPS36 family &  Contains 1 GLUE domain

uniprot_information:
SwissProt: Q86VN1 # The GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates the binding to ubiquitin and phosphoinosides# Belongs to the VPS36 family &  Contains 1 GLUE domain


uniprot_information_type:
SwissProt: Q9NSV4 # DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction (By similarity)# Belongs to the formin homology family. Diaphanous subfamily &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain

uniprot_information:
SwissProt: Q9NSV4 # DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction (By similarity)# Belongs to the formin homology family. Diaphanous subfamily &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


uniprot_information_type:
SwissProt: Q9UI36 # The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain# Belongs to the DACH/dachshund family

uniprot_information:
SwissProt: Q9UI36 # The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain# Belongs to the DACH/dachshund family


uniprot_information_type:
SwissProt: Q9BZ29 # The DHR-2 domain is necessary and sufficient for the GEF activity# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q9BZ29 # The DHR-2 domain is necessary and sufficient for the GEF activity# Belongs to the DOCK family &  Contains 1 DHR-1 (CZH-1) domain &  Contains 1 DHR-2 (CZH-2) domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q8IZF0 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the cation-nonselective channel family

uniprot_information:
SwissProt: Q8IZF0 # Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position# Belongs to the cation-nonselective channel family


uniprot_information_type:
SwissProt: Q58A45 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q58A45 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8NFP9 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer (By similarity)# Belongs to the WD repeat neurobeachin family &  Contains 1 BEACH domain &  Contains 5 WD repeats

uniprot_information:
SwissProt: Q8NFP9 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer (By similarity)# Belongs to the WD repeat neurobeachin family &  Contains 1 BEACH domain &  Contains 5 WD repeats


uniprot_information_type:
SwissProt: Q5SZK8 # The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding (By similarity)# Belongs to the FRAS1 family &  Contains 5 Calx-beta domains &  Contains 12 CSPG (NG2) repeats

uniprot_information:
SwissProt: Q5SZK8 # The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding (By similarity)# Belongs to the FRAS1 family &  Contains 5 Calx-beta domains &  Contains 12 CSPG (NG2) repeats


uniprot_information_type: SwissProt: Q96T68
uniprot_information:
Belongs to the histone-lysine methyltransferase family &  Contains 1 MBD (methyl-CpG-binding) domain &  Contains 1 pre-SET domain &  Contains 1 SET domain


uniprot_information_type:
SwissProt: O60858 # The RING-type zinc finger is required for auto-polyubiquitination &  The C-terminal domain transmembrane domain is indispensable for the localization to the ER# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: O60858 # The RING-type zinc finger is required for auto-polyubiquitination &  The C-terminal domain transmembrane domain is indispensable for the localization to the ER# Belongs to the TRIM/RBCC family &  Contains 1 B box-type zinc finger &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9Y2Z0 # The CS domain mediates interaction with HSP90# Belongs to the SUGT1 family &  Contains 1 CS domain &  Contains 1 SGS domain &  Contains 3 TPR repeats

uniprot_information:
SwissProt: Q9Y2Z0 # The CS domain mediates interaction with HSP90# Belongs to the SUGT1 family &  Contains 1 CS domain &  Contains 1 SGS domain &  Contains 3 TPR repeats


uniprot_information_type: SwissProt: Q8WWI1
uniprot_information:
Contains 1 CH (calponin-homology) domain &  Contains 1 LIM zinc-binding domain &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: Q9NV92 # The PY (WW-binding) motifs are required for E3 ubiquitin-protein ligase activation and for ubiquitination#

uniprot_information:
SwissProt: Q9NV92 # The PY (WW-binding) motifs are required for E3 ubiquitin-protein ligase activation and for ubiquitination#


uniprot_information_type:
SwissProt: Q13217 # The J domain mediates interaction with HSPA8# Contains 1 J domain &  Contains 9 TPR repeats

uniprot_information:
SwissProt: Q13217 # The J domain mediates interaction with HSPA8# Contains 1 J domain &  Contains 9 TPR repeats


uniprot_information_type:
SwissProt: P10114 # The effector domain mediates the interaction with RUNDC3A (By similarity)# Belongs to the small GTPase superfamily. Ras family

uniprot_information:
SwissProt: P10114 # The effector domain mediates the interaction with RUNDC3A (By similarity)# Belongs to the small GTPase superfamily. Ras family


uniprot_information_type: SwissProt: Q14155
uniprot_information:
Contains 1 CH (calponin-homology) domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: O15068 # The CRAL-TRIO domain is involved in interaction with inositol phospholipids &  The DH domain is involved in interaction with CCPG1 (By similarity)# Belongs to the MCF2 family &  Contains 1 CRAL-TRIO domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 SH3 domain &  Contains 1 spectrin repeat

uniprot_information:
SwissProt: O15068 # The CRAL-TRIO domain is involved in interaction with inositol phospholipids &  The DH domain is involved in interaction with CCPG1 (By similarity)# Belongs to the MCF2 family &  Contains 1 CRAL-TRIO domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 SH3 domain &  Contains 1 spectrin repeat


uniprot_information_type: SwissProt: P08709
uniprot_information:
Belongs to the peptidase S1 family &  Contains 2 EGF-like domains &  Contains 1 Gla (gamma-carboxy-glutamate) domain &  Contains 1 peptidase S1 domain


uniprot_information_type: SwissProt: Q99973
uniprot_information:
Contains 1 NACHT domain &  Contains 4 TEP1 N-terminal repeats &  Contains 1 TROVE domain &  Contains 21 WD repeats


uniprot_information_type:
SwissProt: Q9Y5B9 # The Glu-rich acidic region in C-terminus is essential for FACT activity# Belongs to the peptidase M24 family. SPT16 subfamily

uniprot_information:
SwissProt: Q9Y5B9 # The Glu-rich acidic region in C-terminus is essential for FACT activity# Belongs to the peptidase M24 family. SPT16 subfamily


uniprot_information_type:
SwissProt: Q96IF1 # LIM region interacts with CTNNA1. The preLIM region binds directly actin filaments &  LIM-2 and LIM-3 domains mediate the interaction with the N-terminal region of AURKA. The association between LATS2 and JUB required the second LIM domain of JUB# Belongs to the zyxin/ajuba family &  Contains 3 LIM zinc-binding domains

uniprot_information:
SwissProt: Q96IF1 # LIM region interacts with CTNNA1. The preLIM region binds directly actin filaments &  LIM-2 and LIM-3 domains mediate the interaction with the N-terminal region of AURKA. The association between LATS2 and JUB required the second LIM domain of JUB# Belongs to the zyxin/ajuba family &  Contains 3 LIM zinc-binding domains


uniprot_information_type:
SwissProt: Q9H7J1 # The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes# Contains 1 CBM21 (carbohydrate binding type-21) domain

uniprot_information:
SwissProt: Q9H7J1 # The CBM21 domain is known to be involved in the localization to glycogen and is characteristic of some regulatory subunit of phosphatase complexes# Contains 1 CBM21 (carbohydrate binding type-21) domain


uniprot_information_type:
SwissProt: Q96JJ6 # The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids (By similarity)# Belongs to the junctophilin family &  Contains 8 MORN repeats

uniprot_information:
SwissProt: Q96JJ6 # The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids (By similarity)# Belongs to the junctophilin family &  Contains 8 MORN repeats


uniprot_information_type: SwissProt: Q9Y572
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9ULT8
uniprot_information:
Belongs to the UPL family. K-HECT subfamily &  Contains 4 ANK repeats &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 1 MIB/HERC2 domain


uniprot_information_type:
SwissProt: Q00532 # The [NKR]KIAxRE motif seems to be a cyclin-binding region# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q00532 # The [NKR]KIAxRE motif seems to be a cyclin-binding region# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8N4C6 # The coiled coil region from Asn-1611 to Pro-1693 is necessary and sufficient for the targeting to centrosome# Contains 5 EF-hand domains

uniprot_information:
SwissProt: Q8N4C6 # The coiled coil region from Asn-1611 to Pro-1693 is necessary and sufficient for the targeting to centrosome# Contains 5 EF-hand domains


uniprot_information_type:
SwissProt: Q8NCM2 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily &  Contains 1 cyclic nucleotide-binding domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain

uniprot_information:
SwissProt: Q8NCM2 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position# Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily &  Contains 1 cyclic nucleotide-binding domain &  Contains 1 PAC (PAS-associated C-terminal) domain &  Contains 1 PAS (PER-ARNT-SIM) domain


uniprot_information_type:
SwissProt: Q92784 # The PHD-type zinc fingers mediate the binding to acetylated histones# Belongs to the requiem/DPF family &  Contains 1 C2H2-type zinc finger &  Contains 2 PHD-type zinc fingers

uniprot_information:
SwissProt: Q92784 # The PHD-type zinc fingers mediate the binding to acetylated histones# Belongs to the requiem/DPF family &  Contains 1 C2H2-type zinc finger &  Contains 2 PHD-type zinc fingers


uniprot_information_type:
SwissProt: Q14767 # Associates covalently with small latent TGF-beta complex via Repeat B and Repeat C (By similarity)# Belongs to the LTBP family &  Contains 20 EGF-like domains &  Contains 4 TB (TGF-beta binding) domains

uniprot_information:
SwissProt: Q14767 # Associates covalently with small latent TGF-beta complex via Repeat B and Repeat C (By similarity)# Belongs to the LTBP family &  Contains 20 EGF-like domains &  Contains 4 TB (TGF-beta binding) domains


uniprot_information_type: SwissProt: Q9Y6S9
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily &  Contains 1 MIT domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8N966 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q8N966 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: Q86XR5 # The proline-rich attachment domain (PRAD) binds the AChE catalytic subunits (By similarity)# Contains 1 PRAD (Pro-rich attachment) domain

uniprot_information:
SwissProt: Q86XR5 # The proline-rich attachment domain (PRAD) binds the AChE catalytic subunits (By similarity)# Contains 1 PRAD (Pro-rich attachment) domain


uniprot_information_type:
SwissProt: Q96Q27 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 12 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q96Q27 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 12 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: P01009 # The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable# Belongs to the serpin family

uniprot_information:
SwissProt: P01009 # The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable# Belongs to the serpin family


uniprot_information_type:
SwissProt: Q14934 # Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors (By similarity)# Contains 1 IPT/TIG domain &  Contains 1 RHD (Rel-like) domain

uniprot_information:
SwissProt: Q14934 # Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors (By similarity)# Contains 1 IPT/TIG domain &  Contains 1 RHD (Rel-like) domain


uniprot_information_type:
SwissProt: Q7L622 # Ubiquitin ligase activity is mediated by two distinct domains, PHD-type zinc fingers 2 and 3. The use of these distinct domains may allow ubiquitination of different targets by each domain. The HECT domain is catalytically inactive and does not contribute to this activity# Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 3 PHD-type zinc fingers

uniprot_information:
SwissProt: Q7L622 # Ubiquitin ligase activity is mediated by two distinct domains, PHD-type zinc fingers 2 and 3. The use of these distinct domains may allow ubiquitination of different targets by each domain. The HECT domain is catalytically inactive and does not contribute to this activity# Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 3 PHD-type zinc fingers


uniprot_information_type:
SwissProt: Q96NI6 # Lacks a cytoplasmic PDZ-binding motif, which has been implicated in function of related LRFN proteins# Belongs to the LRFN family &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 7 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q96NI6 # Lacks a cytoplasmic PDZ-binding motif, which has been implicated in function of related LRFN proteins# Belongs to the LRFN family &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 7 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q8WXH5 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SH2 domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q8WXH5 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SH2 domain &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: Q9Y4D1 # The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus# Belongs to the formin homology family &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain

uniprot_information:
SwissProt: Q9Y4D1 # The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus# Belongs to the formin homology family &  Contains 1 DAD (diaphanous autoregulatory) domain &  Contains 1 FH1 (formin homology 1) domain &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


uniprot_information_type:
SwissProt: Q8WXH0 # The KASH domain mediates the nuclear envelope targeting# Belongs to the nesprin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 1 KASH domain &  Contains 13 LRR (leucine-rich) repeats &  Contains 9 spectrin repeats

uniprot_information:
SwissProt: Q8WXH0 # The KASH domain mediates the nuclear envelope targeting# Belongs to the nesprin family &  Contains 1 actin-binding domain &  Contains 2 CH (calponin-homology) domains &  Contains 1 KASH domain &  Contains 13 LRR (leucine-rich) repeats &  Contains 9 spectrin repeats


uniprot_information_type:
SwissProt: P24588 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Contains 1 AKAP domain

uniprot_information:
SwissProt: P24588 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Contains 1 AKAP domain


uniprot_information_type: SwissProt: Q9NQX3
uniprot_information:
In the N-terminal section; belongs to the moaB/mog family &  In the C-terminal section; belongs to the moeA family


uniprot_information_type:
SwissProt: Q8N428 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain

uniprot_information:
SwissProt: Q8N428 # There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding (By similarity) &  The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity (By similarity)# Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily &  Contains 1 ricin B-type lectin domain


uniprot_information_type:
SwissProt: P49768 # The PAL motif is required for normal active site conformation# Belongs to the peptidase A22A family

uniprot_information:
SwissProt: P49768 # The PAL motif is required for normal active site conformation# Belongs to the peptidase A22A family


uniprot_information_type: SwissProt: O95428
uniprot_information:
Belongs to the papilin family &  Contains 1 BPTI/Kunitz inhibitor domain &  Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 PLAC domain &  Contains 5 TSP type-1 domains


uniprot_information_type: SwissProt: O95718
uniprot_information:
Belongs to the nuclear hormone receptor family. NR3 subfamily &  Contains 1 nuclear receptor DNA-binding domain


uniprot_information_type: SwissProt: Q9P2I0
uniprot_information:
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily


uniprot_information_type:
SwissProt: Q14204 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function# Belongs to the dynein heavy chain family

uniprot_information:
SwissProt: Q14204 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function# Belongs to the dynein heavy chain family


uniprot_information_type: SwissProt: Q8NDG6
uniprot_information:
Belongs to the DEAD box helicase family. DEAH subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain &  Contains 1 Tudor domain


uniprot_information_type:
SwissProt: Q27J81 # The WH2 domain acts as the DAD (diaphanous autoregulatory) domain and binds to actin monomers (By similarity) &  Regulated by autoinhibition due to intramolecular GBD-DAD binding (By similarity) &  The severing activity is dependent on covalent attachment of the FH2 domain to the C-terminus (By similarity)# Belongs to the formin homology family &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain &  Contains 1 WH2 domain

uniprot_information:
SwissProt: Q27J81 # The WH2 domain acts as the DAD (diaphanous autoregulatory) domain and binds to actin monomers (By similarity) &  Regulated by autoinhibition due to intramolecular GBD-DAD binding (By similarity) &  The severing activity is dependent on covalent attachment of the FH2 domain to the C-terminus (By similarity)# Belongs to the formin homology family &  Contains 1 FH2 (formin homology 2) domain &  Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain &  Contains 1 WH2 domain


uniprot_information_type: SwissProt: B2RXF5
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family. ZNF238 subfamily &  Contains 1 BTB (POZ) domain &  Contains 4 C2H2-type zinc fingers


uniprot_information_type: SwissProt: P28472
uniprot_information:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB3 sub-subfamily


uniprot_information_type: SwissProt: O95714
uniprot_information:
Contains 1 cytochrome b5 heme-binding domain &  Contains 1 DOC domain &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 1 MIB/HERC2 domain &  Contains 19 RCC1 repeats &  Contains 6 WD repeats &  Contains 1 ZZ-type zinc finger


uniprot_information_type:
SwissProt: Q9ULG1 # The DBINO region is involved in binding to DNA# Belongs to the SNF2/RAD54 helicase family &  Contains 1 DBINO domain &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain

uniprot_information:
SwissProt: Q9ULG1 # The DBINO region is involved in binding to DNA# Belongs to the SNF2/RAD54 helicase family &  Contains 1 DBINO domain &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q9H223 # The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity)# Contains 1 EF-hand domain &  Contains 1 EH domain

uniprot_information:
SwissProt: Q9H223 # The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins (By similarity)# Contains 1 EF-hand domain &  Contains 1 EH domain


uniprot_information_type:
SwissProt: Q68DD2 # The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity)# Contains 1 C2 domain &  Contains 1 PLA2c domain

uniprot_information:
SwissProt: Q68DD2 # The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity)# Contains 1 C2 domain &  Contains 1 PLA2c domain


uniprot_information_type:
SwissProt: Q8IWV7 # The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif# Belongs to the UBR1 family &  Contains 1 RING-type zinc finger &  Contains 1 UBR-type zinc finger

uniprot_information:
SwissProt: Q8IWV7 # The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif# Belongs to the UBR1 family &  Contains 1 RING-type zinc finger &  Contains 1 UBR-type zinc finger


uniprot_information_type: SwissProt: Q8IWY8
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 6 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type:
SwissProt: O14863 # Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc (By similarity)# Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily

uniprot_information:
SwissProt: O14863 # Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc (By similarity)# Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily


uniprot_information_type: SwissProt: P35555
uniprot_information:
Belongs to the fibrillin family &  Contains 47 EGF-like domains &  Contains 9 TB (TGF-beta binding) domains


uniprot_information_type: SwissProt: Q96QT4
uniprot_information:
In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily &  In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM7 sub-subfamily &  Contains 1 alpha-type protein kinase domain


uniprot_information_type: SwissProt: Q2VWP7
uniprot_information:
Belongs to the immunoglobulin superfamily. DCC family &  Contains 5 fibronectin type-III domains &  Contains 4 Ig-like (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q15751
uniprot_information:
Contains 1 B30.2/SPRY domain &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 14 RCC1 repeats &  Contains 11 WD repeats


uniprot_information_type:
SwissProt: Q96DP5 # Composed of an N- and a C-terminal domain. The N-terminal domain carries the tetrahydrofolate (THF)-binding site and the C-terminal domain is presumably involved in positioning the Met-tRNA substrate for the formylation reaction# Belongs to the fmt family

uniprot_information:
SwissProt: Q96DP5 # Composed of an N- and a C-terminal domain. The N-terminal domain carries the tetrahydrofolate (THF)-binding site and the C-terminal domain is presumably involved in positioning the Met-tRNA substrate for the formylation reaction# Belongs to the fmt family


uniprot_information_type: SwissProt: Q8IVU1
uniprot_information:
Belongs to the immunoglobulin superfamily. DCC family &  Contains 2 fibronectin type-III domains &  Contains 4 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q8TDY8
uniprot_information:
Belongs to the immunoglobulin superfamily. DCC family &  Contains 5 fibronectin type-III domains &  Contains 4 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q9UKX5 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain

uniprot_information:
SwissProt: Q9UKX5 # The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage# Belongs to the integrin alpha chain family &  Contains 7 FG-GAP repeats &  Contains 1 VWFA domain


uniprot_information_type: SwissProt: B2RTY4
uniprot_information:
Contains 5 IQ domains &  Contains 2 myosin head-like domains &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 Ras-associating domain &  Contains 1 Rho-GAP domain


uniprot_information_type: SwissProt: Q6PHR2
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily &  Contains 2 MIT domains &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8WWG1 # The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity) &  ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity)# Belongs to the neuregulin family &  Contains 1 EGF-like domain

uniprot_information:
SwissProt: Q8WWG1 # The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity) &  ERBB receptor binding is elicited entirely by the EGF-like domain (By similarity)# Belongs to the neuregulin family &  Contains 1 EGF-like domain


uniprot_information_type:
SwissProt: Q9UKP4 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 8 TSP type-1 domains

uniprot_information:
SwissProt: Q9UKP4 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 8 TSP type-1 domains


uniprot_information_type:
SwissProt: Q14696 # The LDLR maturation activity resides in the N- and C-terminal unstructured regions# Belongs to the MESD family

uniprot_information:
SwissProt: Q14696 # The LDLR maturation activity resides in the N- and C-terminal unstructured regions# Belongs to the MESD family


uniprot_information_type:
SwissProt: Q6ZN04 # Binds RNA through its KH domains# Contains 2 KH domains &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q6ZN04 # Binds RNA through its KH domains# Contains 2 KH domains &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q9BZB8 # The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA (By similarity)# Belongs to the RRM CPEB family &  Contains 2 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: Q9BZB8 # The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA (By similarity)# Belongs to the RRM CPEB family &  Contains 2 RRM (RNA recognition motif) domains


uniprot_information_type:
SwissProt: Q9Y2Y9 # The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions# Belongs to the Sp1 C2H2-type zinc-finger protein family &  Contains 3 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q9Y2Y9 # The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions# Belongs to the Sp1 C2H2-type zinc-finger protein family &  Contains 3 C2H2-type zinc fingers


uniprot_information_type: SwissProt: P07996
uniprot_information:
Belongs to the thrombospondin family &  Contains 3 EGF-like domains &  Contains 1 TSP C-terminal (TSPC) domain &  Contains 1 TSP N-terminal (TSPN) domain &  Contains 3 TSP type-1 domains &  Contains 8 TSP type-3 repeats &  Contains 1 VWFC domain


uniprot_information_type:
SwissProt: Q9P2K8 # Kinase domain 1 is a degenerate kinase domain &  RWD domain is reported to interact with GCN1L1# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily &  Contains 2 protein kinase domains &  Contains 1 RWD domain

uniprot_information:
SwissProt: Q9P2K8 # Kinase domain 1 is a degenerate kinase domain &  RWD domain is reported to interact with GCN1L1# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily &  Contains 2 protein kinase domains &  Contains 1 RWD domain


uniprot_information_type:
SwissProt: Q8IWI9 # Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 T-box DNA-binding domain

uniprot_information:
SwissProt: Q8IWI9 # Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 T-box DNA-binding domain


uniprot_information_type: SwissProt: Q9P2P6
uniprot_information:
Belongs to the kinesin-like protein family &  Contains 1 FHA domain &  Contains 1 kinesin-motor domain &  Contains 1 START domain


uniprot_information_type:
SwissProt: P40818 # The MIT domain is required for endosomal localization, CHMP1B-binding, maintenance of ESCRT-0 stability and EGFR degradation &  The rhodanese domain is sufficent for RNF41-binding (By similarity)# Belongs to the peptidase C19 family &  Contains 1 MIT domain &  Contains 1 rhodanese domain

uniprot_information:
SwissProt: P40818 # The MIT domain is required for endosomal localization, CHMP1B-binding, maintenance of ESCRT-0 stability and EGFR degradation &  The rhodanese domain is sufficent for RNF41-binding (By similarity)# Belongs to the peptidase C19 family &  Contains 1 MIT domain &  Contains 1 rhodanese domain


uniprot_information_type:
SwissProt: Q6ZMI3 # The olfactomedin-like domain mediates NFASC/neurofascin and NRCAM binding (By similarity)# Contains 2 collagen-like domains &  Contains 1 olfactomedin-like domain

uniprot_information:
SwissProt: Q6ZMI3 # The olfactomedin-like domain mediates NFASC/neurofascin and NRCAM binding (By similarity)# Contains 2 collagen-like domains &  Contains 1 olfactomedin-like domain


uniprot_information_type:
SwissProt: Q0VF96 # The head region is responsible for junction-based distribution (By similarity)# Belongs to the cingulin family

uniprot_information:
SwissProt: Q0VF96 # The head region is responsible for junction-based distribution (By similarity)# Belongs to the cingulin family


uniprot_information_type: SwissProt: Q92859
uniprot_information:
Belongs to the immunoglobulin superfamily. DCC family &  Contains 6 fibronectin type-III domains &  Contains 4 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: Q5ZPR3
uniprot_information:
Belongs to the immunoglobulin superfamily. BTN/MOG family &  Contains 2 Ig-like C2-type (immunoglobulin-like) domains &  Contains 2 Ig-like V-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: P29590 # Interacts with PKM2 via its coiled-coil domain# Contains 2 B box-type zinc fingers &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: P29590 # Interacts with PKM2 via its coiled-coil domain# Contains 2 B box-type zinc fingers &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q8TF30 # The N-terminal region associates with membranes, the coiled-coil region binds to microtubules and the WH2 domains promotes actin nucleation# Contains 2 WH2 domains

uniprot_information:
SwissProt: Q8TF30 # The N-terminal region associates with membranes, the coiled-coil region binds to microtubules and the WH2 domains promotes actin nucleation# Contains 2 WH2 domains


uniprot_information_type: SwissProt: Q7Z7L9
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 14 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: Q96L96
uniprot_information:
Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily &  Contains 1 alpha-type protein kinase domain &  Contains 1 Ig-like (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q12802 # Both the DH and PH domains are required for transforming activity# Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger

uniprot_information:
SwissProt: Q12802 # Both the DH and PH domains are required for transforming activity# Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger


uniprot_information_type: SwissProt: P08069
uniprot_information:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily &  Contains 3 fibronectin type-III domains &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9H672 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 7 ANK repeats &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q9H672 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes (By similarity)# Contains 7 ANK repeats &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: Q9H9P5 # Although this protein contains a RING domain, intrinsic E3 ligase activity has not been proven (PubMed:20148946)# Belongs to the unkempt family &  Contains 4 C3H1-type zinc fingers &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q9H9P5 # Although this protein contains a RING domain, intrinsic E3 ligase activity has not been proven (PubMed:20148946)# Belongs to the unkempt family &  Contains 4 C3H1-type zinc fingers &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q8NFA2 # The PX domain mediates lipid-binding, localization to the plasma membrane and is required for NOX1 activation &  The SH3 domains mediate interaction with CYBA/p22phox. Also mediates intramolecular interaction with the proline-rich region# Contains 1 PX (phox homology) domain &  Contains 2 SH3 domains

uniprot_information:
SwissProt: Q8NFA2 # The PX domain mediates lipid-binding, localization to the plasma membrane and is required for NOX1 activation &  The SH3 domains mediate interaction with CYBA/p22phox. Also mediates intramolecular interaction with the proline-rich region# Contains 1 PX (phox homology) domain &  Contains 2 SH3 domains


uniprot_information_type:
SwissProt: Q92793 # The KIX domain mediates binding to HIV-1 Tat# Contains 1 bromo domain &  Contains 1 KIX domain &  Contains 2 TAZ-type zinc fingers &  Contains 1 ZZ-type zinc finger

uniprot_information:
SwissProt: Q92793 # The KIX domain mediates binding to HIV-1 Tat# Contains 1 bromo domain &  Contains 1 KIX domain &  Contains 2 TAZ-type zinc fingers &  Contains 1 ZZ-type zinc finger


uniprot_information_type:
SwissProt: Q49A26 # The A.T hook DNA-binding domain is required for the interaction with MAPK14# Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily &  Contains 1 A.T hook DNA-binding domain &  Contains 1 PWWP domain

uniprot_information:
SwissProt: Q49A26 # The A.T hook DNA-binding domain is required for the interaction with MAPK14# Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily &  Contains 1 A.T hook DNA-binding domain &  Contains 1 PWWP domain


uniprot_information_type:
SwissProt: P35749 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: P35749 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type: SwissProt: Q96Q15
uniprot_information:
Belongs to the PI3/PI4-kinase family &  Contains 1 FAT domain &  Contains 1 FATC domain &  Contains 1 HEAT repeat &  Contains 1 PI3K/PI4K domain


uniprot_information_type: SwissProt: Q63HK3
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 6 C2H2-type zinc fingers &  Contains 1 KRAB domain &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: P0C7X2
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 2 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q8IUQ4 # The RING-type zinc finger domain is essential for ubiquitin ligase activity &  The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family (By similarity)# Belongs to the SINA (Seven in absentia) family &  Contains 1 RING-type zinc finger &  Contains 1 SIAH-type zinc finger

uniprot_information:
SwissProt: Q8IUQ4 # The RING-type zinc finger domain is essential for ubiquitin ligase activity &  The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family (By similarity)# Belongs to the SINA (Seven in absentia) family &  Contains 1 RING-type zinc finger &  Contains 1 SIAH-type zinc finger


uniprot_information_type:
SwissProt: Q7Z614 # The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes# Belongs to the sorting nexin family &  Contains 1 PX (phox homology) domain

uniprot_information:
SwissProt: Q7Z614 # The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes# Belongs to the sorting nexin family &  Contains 1 PX (phox homology) domain


uniprot_information_type: SwissProt: P19784
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q6PEW0 # The serine protease domain lacks the essential His, Asp, and Ser residues of the catalytic triad at positions 83, 129 and 221 and is predicted to be inactive# Belongs to the peptidase S1 family. Plasma kallikrein subfamily &  Contains 1 peptidase S1 domain

uniprot_information:
SwissProt: Q6PEW0 # The serine protease domain lacks the essential His, Asp, and Ser residues of the catalytic triad at positions 83, 129 and 221 and is predicted to be inactive# Belongs to the peptidase S1 family. Plasma kallikrein subfamily &  Contains 1 peptidase S1 domain


uniprot_information_type:
SwissProt: Q8WTX9 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q8WTX9 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family &  Contains 1 DHHC-type zinc finger


uniprot_information_type: SwissProt: P17023
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 10 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q8NB16 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q8NB16 # The protein kinase domain is predicted to be catalytically inactive# Belongs to the protein kinase superfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q7L5A8 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the SCS7 family &  Contains 1 cytochrome b5 heme-binding domain

uniprot_information:
SwissProt: Q7L5A8 # The histidine box domains may contain the active site and/or be involved in metal ion binding# Belongs to the SCS7 family &  Contains 1 cytochrome b5 heme-binding domain


uniprot_information_type:
SwissProt: P56945 # Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with CASL (By similarity) &  A serine-rich region promotes activation of the serum response element (SRE) &  The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of focal adhesion kinase 1# Belongs to the CAS family &  Contains 1 SH3 domain

uniprot_information:
SwissProt: P56945 # Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with CASL (By similarity) &  A serine-rich region promotes activation of the serum response element (SRE) &  The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of focal adhesion kinase 1# Belongs to the CAS family &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q15046 # The N-terminal domain (1-65) of the cytoplasmic isoform is a functional tRNA-binding domain (By similarity), is required for nuclear localization, is involved in the interaction with DARS, but has a repulsive role in the binding to EEF1A1. A central domain (208-259) is involved in homodimerization and is required for interaction with HIV-1 GAG and incorporation into virions. The C-terminal domain (452-597) is not required for interaction with AIMP2# Belongs to the class-II aminoacyl-tRNA synthetase family

uniprot_information:
SwissProt: Q15046 # The N-terminal domain (1-65) of the cytoplasmic isoform is a functional tRNA-binding domain (By similarity), is required for nuclear localization, is involved in the interaction with DARS, but has a repulsive role in the binding to EEF1A1. A central domain (208-259) is involved in homodimerization and is required for interaction with HIV-1 GAG and incorporation into virions. The C-terminal domain (452-597) is not required for interaction with AIMP2# Belongs to the class-II aminoacyl-tRNA synthetase family


uniprot_information_type:
SwissProt: Q8TE60 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 5 TSP type-1 domains

uniprot_information:
SwissProt: Q8TE60 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 5 TSP type-1 domains


uniprot_information_type: SwissProt: Q7Z442
uniprot_information:
Belongs to the polycystin family &  Contains 1 C-type lectin domain &  Contains 1 GPS domain &  Contains 1 PLAT domain &  Contains 1 REJ domain &  Contains 1 SUEL-type lectin domain


uniprot_information_type: SwissProt: O75808
uniprot_information:
Belongs to the peptidase C2 family &  Contains 1 calpain catalytic domain &  Contains 5 RanBP2-type zinc fingers


uniprot_information_type:
SwissProt: Q96S21 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the small GTPase superfamily. Rab family &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q96S21 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Belongs to the small GTPase superfamily. Rab family &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: Q9UNE7 # The TPR domain is essential for ubiquitination mediated by UBE2D1# Contains 3 TPR repeats &  Contains 1 U-box domain

uniprot_information:
SwissProt: Q9UNE7 # The TPR domain is essential for ubiquitination mediated by UBE2D1# Contains 3 TPR repeats &  Contains 1 U-box domain


uniprot_information_type: SwissProt: Q6Q0C0
uniprot_information:
Belongs to the WD repeat TRAF7 family &  Contains 1 RING-type zinc finger &  Contains 1 TRAF-type zinc finger &  Contains 7 WD repeats


uniprot_information_type: SwissProt: O15530
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily &  Contains 1 PH domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9NXV2 # The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118# Contains 1 BTB (POZ) domain

uniprot_information:
SwissProt: Q9NXV2 # The BTB (POZ) domain is atypical and mediates the formation of a homopentamer instead of a homotetramer. Homopentamerization is due to the presence of 4 residues in the BTB (POZ) domain: Leu-56, Gly-100, Val-112 and Ala-118# Contains 1 BTB (POZ) domain


uniprot_information_type:
SwissProt: Q9BZE0 # The C2H2-type zinc finger 1 has a major repressor function and is required for CTNNB1 binding (By similarity)# Belongs to the GLI C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q9BZE0 # The C2H2-type zinc finger 1 has a major repressor function and is required for CTNNB1 binding (By similarity)# Belongs to the GLI C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers


uniprot_information_type: SwissProt: Q6EMK4
uniprot_information:
Contains 1 EGF-like domain &  Contains 1 fibronectin type-III domain &  Contains 11 LRR (leucine-rich) repeats


uniprot_information_type: SwissProt: O00418
uniprot_information:
Belongs to the protein kinase superfamily. Alpha-type protein kinase family &  Contains 1 alpha-type protein kinase domain


uniprot_information_type: SwissProt: P05771
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 C2 domain &  Contains 2 phorbol-ester/DAG-type zinc fingers &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q6PCT2
uniprot_information:
Contains 1 CXXC-type zinc finger &  Contains 1 F-box domain &  Contains 4 LRR (leucine-rich) repeats &  Contains 1 PHD-type zinc finger


uniprot_information_type: SwissProt: Q8TD30
uniprot_information:
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily


uniprot_information_type:
SwissProt: Q7L5N7 # The HXXXXD motif is essential for acyltransferase activity (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family &  Contains 2 EF-hand domains

uniprot_information:
SwissProt: Q7L5N7 # The HXXXXD motif is essential for acyltransferase activity (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family &  Contains 2 EF-hand domains


uniprot_information_type:
SwissProt: P51511 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: P51511 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: Q12968 # Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors# Contains 1 RHD (Rel-like) domain

uniprot_information:
SwissProt: Q12968 # Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors# Contains 1 RHD (Rel-like) domain


uniprot_information_type:
SwissProt: Q13425 # The PH 1 domain mediates the oligomerization in a calcium dependent manner (By similarity) &  The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity) &  The SU domain binds calmodulin in a calcium-dependent manner (By similarity)# Belongs to the syntrophin family &  Contains 1 PDZ (DHR) domain &  Contains 2 PH domains &  Contains 1 SU (syntrophin unique) domain

uniprot_information:
SwissProt: Q13425 # The PH 1 domain mediates the oligomerization in a calcium dependent manner (By similarity) &  The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity) &  The SU domain binds calmodulin in a calcium-dependent manner (By similarity)# Belongs to the syntrophin family &  Contains 1 PDZ (DHR) domain &  Contains 2 PH domains &  Contains 1 SU (syntrophin unique) domain


uniprot_information_type: SwissProt: Q9UMR2
uniprot_information:
Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q8ND25 # The RING-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8ND25 # The RING-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q9C0A0
uniprot_information:
Belongs to the neurexin family &  Contains 2 EGF-like domains &  Contains 1 F5/8 type C domain &  Contains 1 fibrinogen C-terminal domain &  Contains 4 laminin G-like domains


uniprot_information_type:
SwissProt: Q9NZC7 # The WW 1 domain mediates interaction with TP53, and probably TP73, TFAP2C, LITAF and WBP1# Belongs to the short-chain dehydrogenases/reductases (SDR) family &  Contains 2 WW domains

uniprot_information:
SwissProt: Q9NZC7 # The WW 1 domain mediates interaction with TP53, and probably TP73, TFAP2C, LITAF and WBP1# Belongs to the short-chain dehydrogenases/reductases (SDR) family &  Contains 2 WW domains


uniprot_information_type:
SwissProt: Q8WXH2 # The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids (By similarity)# Belongs to the junctophilin family &  Contains 8 MORN repeats

uniprot_information:
SwissProt: Q8WXH2 # The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids (By similarity)# Belongs to the junctophilin family &  Contains 8 MORN repeats


uniprot_information_type:
SwissProt: Q8IX07 # The CCHC-type zinc fingers 1, 5, 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity)# Belongs to the FOG (Friend of GATA) family &  Contains 4 C2H2-type zinc fingers &  Contains 5 C2HC-type zinc fingers

uniprot_information:
SwissProt: Q8IX07 # The CCHC-type zinc fingers 1, 5, 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity)# Belongs to the FOG (Friend of GATA) family &  Contains 4 C2H2-type zinc fingers &  Contains 5 C2HC-type zinc fingers


uniprot_information_type:
SwissProt: Q9H211 # The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination (By similarity)# Belongs to the Cdt1 family

uniprot_information:
SwissProt: Q9H211 # The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination (By similarity)# Belongs to the Cdt1 family


uniprot_information_type:
SwissProt: Q8WWL2 # Binds to actin monomers via the WH2 domain (By similarity) &  The Spir-box targets binding to intracellular membrane structures (By similarity)# Belongs to the spire family &  Contains 1 KIND domain &  Contains 3 WH2 domains

uniprot_information:
SwissProt: Q8WWL2 # Binds to actin monomers via the WH2 domain (By similarity) &  The Spir-box targets binding to intracellular membrane structures (By similarity)# Belongs to the spire family &  Contains 1 KIND domain &  Contains 3 WH2 domains


uniprot_information_type:
SwissProt: O00159 # Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to a putative PH domain present in its tail domain (By similarity)# Contains 2 IQ domains &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: O00159 # Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to a putative PH domain present in its tail domain (By similarity)# Contains 2 IQ domains &  Contains 1 myosin head-like domain


uniprot_information_type:
SwissProt: Q6P2Q9 # The MPN domain has structural similarity with viral ribonucleases and RNase H, but unlike RNases, it does not bind any metal ions# Contains 1 MPN (JAB/Mov34) domain

uniprot_information:
SwissProt: Q6P2Q9 # The MPN domain has structural similarity with viral ribonucleases and RNase H, but unlike RNases, it does not bind any metal ions# Contains 1 MPN (JAB/Mov34) domain


uniprot_information_type:
SwissProt: Q8N5S9 # The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition &  The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates (By similarity)# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: Q8N5S9 # The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition &  The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates (By similarity)# Belongs to the protein kinase superfamily. Ser/Thr protein kinase family &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9BYE0 # Has a particular type of basic domain which includes a helix-interrupting proline &  The C-terminal WRPW motif is a transcriptional repression motif which is necessary for interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain

uniprot_information:
SwissProt: Q9BYE0 # Has a particular type of basic domain which includes a helix-interrupting proline &  The C-terminal WRPW motif is a transcriptional repression motif which is necessary for interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins (By similarity)# Contains 1 basic helix-loop-helix (bHLH) domain &  Contains 1 Orange domain


uniprot_information_type:
SwissProt: O75376 # The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3) &  The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity)# Belongs to the N-CoR nuclear receptor corepressors family &  Contains 2 SANT domains

uniprot_information:
SwissProt: O75376 # The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3) &  The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity (By similarity)# Belongs to the N-CoR nuclear receptor corepressors family &  Contains 2 SANT domains


uniprot_information_type: SwissProt: Q9P2J8
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 21 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q6ZVM7 # The GAT domain mediates interaction with TOLLIP# Belongs to the TOM1 family &  Contains 1 GAT domain &  Contains 1 VHS domain

uniprot_information:
SwissProt: Q6ZVM7 # The GAT domain mediates interaction with TOLLIP# Belongs to the TOM1 family &  Contains 1 GAT domain &  Contains 1 VHS domain


uniprot_information_type:
SwissProt: O43572 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Contains 2 RGS domains

uniprot_information:
SwissProt: O43572 # RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer# Contains 2 RGS domains


uniprot_information_type: SwissProt: Q76I76
uniprot_information:
Belongs to the protein-tyrosine phosphatase family &  Contains 1 tyrosine-protein phosphatase domain


uniprot_information_type:
SwissProt: Q9H239 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains

uniprot_information:
SwissProt: Q9H239 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Belongs to the peptidase M10A family &  Contains 4 hemopexin-like domains


uniprot_information_type:
SwissProt: Q8NG50 # C-terminal half (amino acids 134-284) contains cytoplasmic retention domains as well as determinants involved in its stress-induced nucleolar accumulation# Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q8NG50 # C-terminal half (amino acids 134-284) contains cytoplasmic retention domains as well as determinants involved in its stress-induced nucleolar accumulation# Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: Q9UMZ2 # The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2# Contains 1 EH domain

uniprot_information:
SwissProt: Q9UMZ2 # The DFXDF motifs mediate the interaction with gamma-appendage subunits AP1G1 and AP1G2# Contains 1 EH domain


uniprot_information_type:
SwissProt: Q969G3 # The HMG domain is essential for CD4 silencing and CD8 activation; mutation of this domain blocks thymus development (By similarity)# Contains 1 HMG box DNA-binding domain

uniprot_information:
SwissProt: Q969G3 # The HMG domain is essential for CD4 silencing and CD8 activation; mutation of this domain blocks thymus development (By similarity)# Contains 1 HMG box DNA-binding domain


uniprot_information_type:
SwissProt: Q9UQL6 # The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm (By similarity)# Belongs to the histone deacetylase family. Type 2 subfamily

uniprot_information:
SwissProt: Q9UQL6 # The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm (By similarity)# Belongs to the histone deacetylase family. Type 2 subfamily


uniprot_information_type:
SwissProt: Q14CW9 # The SGF11-type zinc finger mediates the interaction with USP22 and ENY2# Belongs to the SGF11 family &  Contains 1 SCA7 domain &  Contains 1 SGF11-type zinc finger

uniprot_information:
SwissProt: Q14CW9 # The SGF11-type zinc finger mediates the interaction with USP22 and ENY2# Belongs to the SGF11 family &  Contains 1 SCA7 domain &  Contains 1 SGF11-type zinc finger


uniprot_information_type:
SwissProt: Q8N3E9 # The C2 domain is a Ca(2+)-dependent membrane-targeting module &  The PH domain mediates interaction with the surface membrane by binding to PIP2# Contains 1 C2 domain &  Contains 3 EF-hand domains &  Contains 1 PH domain &  Contains 1 PI-PLC X-box domain &  Contains 1 PI-PLC Y-box domain

uniprot_information:
SwissProt: Q8N3E9 # The C2 domain is a Ca(2+)-dependent membrane-targeting module &  The PH domain mediates interaction with the surface membrane by binding to PIP2# Contains 1 C2 domain &  Contains 3 EF-hand domains &  Contains 1 PH domain &  Contains 1 PI-PLC X-box domain &  Contains 1 PI-PLC Y-box domain


uniprot_information_type:
SwissProt: O43791 # The MATH domain interacts with H2AFY and BMI1# Belongs to the Tdpoz family &  Contains 1 BTB (POZ) domain &  Contains 1 MATH domain

uniprot_information:
SwissProt: O43791 # The MATH domain interacts with H2AFY and BMI1# Belongs to the Tdpoz family &  Contains 1 BTB (POZ) domain &  Contains 1 MATH domain


uniprot_information_type:
SwissProt: Q14258 # The RING-type zinc finger is important for ISG15 E3 ligase activity and autoISGylation. AutoISGylation negatively regulates ISG15 E3 ligase activity &  The C-terminal B30.2/SPRY domain interacts with the first N-terminal CARD domain of DDX58# Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q14258 # The RING-type zinc finger is important for ISG15 E3 ligase activity and autoISGylation. AutoISGylation negatively regulates ISG15 E3 ligase activity &  The C-terminal B30.2/SPRY domain interacts with the first N-terminal CARD domain of DDX58# Contains 1 B30.2/SPRY domain &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q8NA82 # The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-CH-type zinc finger

uniprot_information:
SwissProt: Q8NA82 # The RING-CH-type zinc finger domain is required for E3 ligase activity (By similarity)# Contains 1 RING-CH-type zinc finger


uniprot_information_type: SwissProt: P17844
uniprot_information:
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily &  Contains 1 helicase ATP-binding domain &  Contains 1 helicase C-terminal domain


uniprot_information_type:
SwissProt: Q9HAU4 # The second and third WW domains are responsible for interaction with the PY-motif of R-SMAD (SMAD1, SMAD2 and SMAD3) &  The C2 domain is involved in autoinhibition of the catalytic activity by interacting with the HECT domain# Contains 1 C2 domain &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 3 WW domains

uniprot_information:
SwissProt: Q9HAU4 # The second and third WW domains are responsible for interaction with the PY-motif of R-SMAD (SMAD1, SMAD2 and SMAD3) &  The C2 domain is involved in autoinhibition of the catalytic activity by interacting with the HECT domain# Contains 1 C2 domain &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 3 WW domains


uniprot_information_type:
SwissProt: P62993 # The SH3 domains mediate interaction with RALGPS1 and SHB# Belongs to the GRB2/sem-5/DRK family &  Contains 1 SH2 domain &  Contains 2 SH3 domains

uniprot_information:
SwissProt: P62993 # The SH3 domains mediate interaction with RALGPS1 and SHB# Belongs to the GRB2/sem-5/DRK family &  Contains 1 SH2 domain &  Contains 2 SH3 domains


uniprot_information_type:
SwissProt: Q70J99 # The MHD1 and MHD2 domains mediate localization on recycling endosomes and lysosome# Belongs to the unc-13 family &  Contains 2 C2 domains &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 MHD2 (MUNC13 homology domain 2) domain

uniprot_information:
SwissProt: Q70J99 # The MHD1 and MHD2 domains mediate localization on recycling endosomes and lysosome# Belongs to the unc-13 family &  Contains 2 C2 domains &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 MHD2 (MUNC13 homology domain 2) domain


uniprot_information_type:
SwissProt: O14543 # The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition &  The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SH2 domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: O14543 # The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition &  The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SH2 domain &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q14526
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily &  Contains 1 BTB (POZ) domain &  Contains 5 C2H2-type zinc fingers


uniprot_information_type: SwissProt: Q8TF76
uniprot_information:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8WUJ1 # The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 73 and 106 (By similarity)# Belongs to the cytochrome b5 family. MAPR subfamily &  Contains 1 cytochrome b5 heme-binding domain

uniprot_information:
SwissProt: Q8WUJ1 # The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 73 and 106 (By similarity)# Belongs to the cytochrome b5 family. MAPR subfamily &  Contains 1 cytochrome b5 heme-binding domain


uniprot_information_type: SwissProt: O43896
uniprot_information:
Belongs to the kinesin-like protein family. Unc-104 subfamily &  Contains 1 FHA domain &  Contains 1 kinesin-motor domain


uniprot_information_type:
SwissProt: Q693B1 # The BTB domain is required for growth-suppressing properties# Contains 1 BTB (POZ) domain

uniprot_information:
SwissProt: Q693B1 # The BTB domain is required for growth-suppressing properties# Contains 1 BTB (POZ) domain


uniprot_information_type:
SwissProt: Q9P225 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family &  Contains 5 LRR (leucine-rich) repeats &  Contains 5 TPR repeats

uniprot_information:
SwissProt: Q9P225 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity)# Belongs to the dynein heavy chain family &  Contains 5 LRR (leucine-rich) repeats &  Contains 5 TPR repeats


uniprot_information_type:
SwissProt: Q9NYC9 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function# Belongs to the dynein heavy chain family

uniprot_information:
SwissProt: Q9NYC9 # Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function# Belongs to the dynein heavy chain family


uniprot_information_type:
SwissProt: Q8IZQ8 # The C-terminal region contains a general transcription activation domain. The N-terminal region, comprising a basic and a Gln-rich domain, confers transcriptional potency and specificity by mediating association with the MADS box of SRF. The basic domain may be required for nuclear localization. The SAP domain is important for transactivation and ternary complex formation (By similarity)# Contains 3 RPEL repeats &  Contains 1 SAP domain

uniprot_information:
SwissProt: Q8IZQ8 # The C-terminal region contains a general transcription activation domain. The N-terminal region, comprising a basic and a Gln-rich domain, confers transcriptional potency and specificity by mediating association with the MADS box of SRF. The basic domain may be required for nuclear localization. The SAP domain is important for transactivation and ternary complex formation (By similarity)# Contains 3 RPEL repeats &  Contains 1 SAP domain


uniprot_information_type: SwissProt: Q9Y5S1
uniprot_information:
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily &  Contains 6 ANK repeats


uniprot_information_type: SwissProt: Q8IVT5
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9UBE8
uniprot_information:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9BUZ4 # The coiled coil domain mediates homo- and hetero-oligomerization (By similarity) &  The MATH/TRAF domain binds to receptor cytoplasmic domains (By similarity)# Belongs to the TNF receptor-associated factor family. B subfamily &  Contains 1 MATH domain &  Contains 1 RING-type zinc finger &  Contains 3 TRAF-type zinc fingers

uniprot_information:
SwissProt: Q9BUZ4 # The coiled coil domain mediates homo- and hetero-oligomerization (By similarity) &  The MATH/TRAF domain binds to receptor cytoplasmic domains (By similarity)# Belongs to the TNF receptor-associated factor family. B subfamily &  Contains 1 MATH domain &  Contains 1 RING-type zinc finger &  Contains 3 TRAF-type zinc fingers


uniprot_information_type:
SwissProt: Q86YS3 # The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B) (By similarity)# Contains 1 EF-hand domain &  Contains 1 RBD-FIP domain

uniprot_information:
SwissProt: Q86YS3 # The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B) (By similarity)# Contains 1 EF-hand domain &  Contains 1 RBD-FIP domain


uniprot_information_type:
SwissProt: O75078 # A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: O75078 # A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain


uniprot_information_type:
SwissProt: P10636 # The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats# Contains 4 Tau/MAP repeats

uniprot_information:
SwissProt: P10636 # The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats# Contains 4 Tau/MAP repeats


uniprot_information_type:
SwissProt: Q9NZI8 # The third and fourth KH domains encompass the protein dimerization motif and are necessary and sufficient for RNA binding. The four KH domains are important for granule formation and SGs targeting. Contains two nuclear export signals, situated within the second and fourth KH domains. The four KH domains are important to suppress HIV-1 infectivity# Belongs to the RRM IMP/VICKZ family &  Contains 4 KH domains &  Contains 2 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: Q9NZI8 # The third and fourth KH domains encompass the protein dimerization motif and are necessary and sufficient for RNA binding. The four KH domains are important for granule formation and SGs targeting. Contains two nuclear export signals, situated within the second and fourth KH domains. The four KH domains are important to suppress HIV-1 infectivity# Belongs to the RRM IMP/VICKZ family &  Contains 4 KH domains &  Contains 2 RRM (RNA recognition motif) domains


uniprot_information_type:
SwissProt: O95251 # The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L &  The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction (By similarity)# Belongs to the MYST (SAS/MOZ) family &  Contains 1 C2HC-type zinc finger

uniprot_information:
SwissProt: O95251 # The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L &  The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction (By similarity)# Belongs to the MYST (SAS/MOZ) family &  Contains 1 C2HC-type zinc finger


uniprot_information_type: SwissProt: Q9H201
uniprot_information:
Belongs to the epsin family &  Contains 1 ENTH (epsin N-terminal homology) domain &  Contains 2 UIM (ubiquitin-interacting motif) repeats


uniprot_information_type: SwissProt: Q8TEU8
uniprot_information:
Belongs to the WFIKKN family &  Contains 2 BPTI/Kunitz inhibitor domains &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 1 Kazal-like domain &  Contains 1 NTR domain &  Contains 1 WAP domain


uniprot_information_type: SwissProt: P52429
uniprot_information:
Belongs to the eukaryotic diacylglycerol kinase family &  Contains 1 DAGKc domain &  Contains 2 phorbol-ester/DAG-type zinc fingers


uniprot_information_type:
SwissProt: P23443 # The autoinhibitory domain is believed to block phosphorylation within the AGC-kinase C-terminal domain and the activation loop &  The TOS (TOR signaling) motif is essential for activation by mTORC1 (By similarity)# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P23443 # The autoinhibitory domain is believed to block phosphorylation within the AGC-kinase C-terminal domain and the activation loop &  The TOS (TOR signaling) motif is essential for activation by mTORC1 (By similarity)# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q12830 # The second PHD-type zinc finger mediates binding to histone H3-K4Me3# Belongs to the PBTF family &  Contains 1 bromo domain &  Contains 1 DDT domain &  Contains 2 PHD-type zinc fingers

uniprot_information:
SwissProt: Q12830 # The second PHD-type zinc finger mediates binding to histone H3-K4Me3# Belongs to the PBTF family &  Contains 1 bromo domain &  Contains 1 DDT domain &  Contains 2 PHD-type zinc fingers


uniprot_information_type: SwissProt: Q96JP2
uniprot_information:
Contains 1 IQ domain &  Contains 1 myosin head-like domain &  Contains 1 MyTH4 domain &  Contains 1 SH3 domain


uniprot_information_type: SwissProt: Q9C0B0
uniprot_information:
Belongs to the unkempt family &  Contains 5 C3H1-type zinc fingers &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q9HCJ0
uniprot_information:
Belongs to the GW182 family &  Contains 1 RRM (RNA recognition motif) domain &  Contains 1 UBA domain


uniprot_information_type:
SwissProt: Q9NYG5 # The RING-type zinc finger domain coordinates an additional third zinc ion# Belongs to the RING-box family &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q9NYG5 # The RING-type zinc finger domain coordinates an additional third zinc ion# Belongs to the RING-box family &  Contains 1 RING-type zinc finger


uniprot_information_type:
SwissProt: Q01167 # The C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity# Contains 1 FHA domain &  Contains 1 fork-head DNA-binding domain

uniprot_information:
SwissProt: Q01167 # The C-terminal part of the DNA-binding domain may contribute to DNA recognition specificity# Contains 1 FHA domain &  Contains 1 fork-head DNA-binding domain


uniprot_information_type:
SwissProt: P25391 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domains VI, IV and G are globular# Contains 17 laminin EGF-like domains &  Contains 5 laminin G-like domains &  Contains 2 laminin IV type A domains &  Contains 1 laminin N-terminal domain

uniprot_information:
SwissProt: P25391 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domains VI, IV and G are globular# Contains 17 laminin EGF-like domains &  Contains 5 laminin G-like domains &  Contains 2 laminin IV type A domains &  Contains 1 laminin N-terminal domain


uniprot_information_type:
SwissProt: Q08AE8 # Binds to actin monomers via the WH2 domain (By similarity) &  The Spir-box targets binding to intracellular membrane structures# Belongs to the spire family &  Contains 1 KIND domain &  Contains 2 WH2 domains

uniprot_information:
SwissProt: Q08AE8 # Binds to actin monomers via the WH2 domain (By similarity) &  The Spir-box targets binding to intracellular membrane structures# Belongs to the spire family &  Contains 1 KIND domain &  Contains 2 WH2 domains


uniprot_information_type:
SwissProt: Q13464 # The C-terminal auto-inhibitory domain interferes with kinase activity. RHOA binding leads to a conformation change and activation of the kinase. Truncated ROCK1 is constitutively activated# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain &  Contains 1 REM (Hr1) repeat

uniprot_information:
SwissProt: Q13464 # The C-terminal auto-inhibitory domain interferes with kinase activity. RHOA binding leads to a conformation change and activation of the kinase. Truncated ROCK1 is constitutively activated# Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 protein kinase domain &  Contains 1 REM (Hr1) repeat


uniprot_information_type:
SwissProt: Q5FWF5 # The N-terminal region seems to be responsible for the association with chromosomes, thus excluding any involvement of the Zn finger in this process# Belongs to the acetyltransferase family. GCN5 subfamily

uniprot_information:
SwissProt: Q5FWF5 # The N-terminal region seems to be responsible for the association with chromosomes, thus excluding any involvement of the Zn finger in this process# Belongs to the acetyltransferase family. GCN5 subfamily


uniprot_information_type:
SwissProt: Q96K83 # Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and hematopoietic system (By similarity)# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 30 C2H2-type zinc fingers

uniprot_information:
SwissProt: Q96K83 # Uses different DNA- and protein-binding zinc fingers to regulate the distinct BMP-Smad and hematopoietic system (By similarity)# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 30 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: P55087 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family

uniprot_information:
SwissProt: P55087 # Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA)# Belongs to the MIP/aquaporin (TC 1.A.8) family


uniprot_information_type:
SwissProt: Q02487 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 5 cadherin domains

uniprot_information:
SwissProt: Q02487 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 5 cadherin domains


uniprot_information_type:
SwissProt: Q9UIS9 # The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions &  The third CXXC-type zinc finger mediates binding to non-methylated CpG dinucleotides &  The transcriptional repression domain (TRD) is involved in transcription repression and in protein interactions# Contains 3 CXXC-type zinc fingers &  Contains 1 MBD (methyl-CpG-binding) domain

uniprot_information:
SwissProt: Q9UIS9 # The methyl-CpG-binding domain (MBD) functions both in binding to methylated DNA and in protein interactions &  The third CXXC-type zinc finger mediates binding to non-methylated CpG dinucleotides &  The transcriptional repression domain (TRD) is involved in transcription repression and in protein interactions# Contains 3 CXXC-type zinc fingers &  Contains 1 MBD (methyl-CpG-binding) domain


uniprot_information_type:
SwissProt: Q5U5Q3 # Binds RNA through its KH domains# Contains 2 KH domains &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q5U5Q3 # Binds RNA through its KH domains# Contains 2 KH domains &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q86TB3
uniprot_information:
Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily &  Contains 1 alpha-type protein kinase domain &  Contains 2 Ig-like (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q96JJ7 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the protein disulfide isomerase family &  Contains 1 thioredoxin domain

uniprot_information:
SwissProt: Q96JJ7 # The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)# Belongs to the protein disulfide isomerase family &  Contains 1 thioredoxin domain


uniprot_information_type:
SwissProt: Q9BYG4 # The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases (By similarity)# Belongs to the PAR6 family &  Contains 1 OPR domain &  Contains 1 PDZ (DHR) domain &  Contains 1 pseudo-CRIB domain

uniprot_information:
SwissProt: Q9BYG4 # The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases (By similarity)# Belongs to the PAR6 family &  Contains 1 OPR domain &  Contains 1 PDZ (DHR) domain &  Contains 1 pseudo-CRIB domain


uniprot_information_type:
SwissProt: Q9GZX9 # The N-terminal domain is sufficient to interact with BMP4 (By similarity)# Belongs to the twisted gastrulation protein family

uniprot_information:
SwissProt: Q9GZX9 # The N-terminal domain is sufficient to interact with BMP4 (By similarity)# Belongs to the twisted gastrulation protein family


uniprot_information_type: SwissProt: Q86YT6
uniprot_information:
Contains 9 ANK repeats &  Contains 2 MIB/HERC2 domains &  Contains 3 RING-type zinc fingers &  Contains 1 ZZ-type zinc finger


uniprot_information_type:
SwissProt: Q16787 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domain G is globular# Contains 15 laminin EGF-like domains &  Contains 5 laminin G-like domains &  Contains 1 laminin IV type A domain &  Contains 1 laminin N-terminal domain

uniprot_information:
SwissProt: Q16787 # The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure &  Domain G is globular# Contains 15 laminin EGF-like domains &  Contains 5 laminin G-like domains &  Contains 1 laminin IV type A domain &  Contains 1 laminin N-terminal domain


uniprot_information_type:
SwissProt: P32926 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 4 cadherin domains

uniprot_information:
SwissProt: P32926 # Calcium may be bound by the cadherin-like repeats (Potential)# Contains 4 cadherin domains


uniprot_information_type:
SwissProt: Q8WVD3 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q8WVD3 # The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)# Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q9C0F0
uniprot_information:
Belongs to the Asx family &  Contains 3 LRR (leucine-rich) repeats &  Contains 1 PHD-type zinc finger


uniprot_information_type:
SwissProt: Q9Y4J8 # The coiled coil domain mediates the interaction with dystrophin and utrophin (By similarity)# Belongs to the dystrophin family. Dystrobrevin subfamily &  Contains 1 ZZ-type zinc finger

uniprot_information:
SwissProt: Q9Y4J8 # The coiled coil domain mediates the interaction with dystrophin and utrophin (By similarity)# Belongs to the dystrophin family. Dystrobrevin subfamily &  Contains 1 ZZ-type zinc finger


uniprot_information_type: SwissProt: Q8NF99
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 9 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: Q96EN8
uniprot_information:
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily &  Contains 1 MOSC domain


uniprot_information_type:
SwissProt: Q13485 # The MH1 and MH2 domains are necessary for interaction with RBPMS# Belongs to the dwarfin/SMAD family &  Contains 1 MH1 (MAD homology 1) domain &  Contains 1 MH2 (MAD homology 2) domain

uniprot_information:
SwissProt: Q13485 # The MH1 and MH2 domains are necessary for interaction with RBPMS# Belongs to the dwarfin/SMAD family &  Contains 1 MH1 (MAD homology 1) domain &  Contains 1 MH2 (MAD homology 2) domain


uniprot_information_type:
SwissProt: Q9UNA4 # The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity# Belongs to the DNA polymerase type-Y family &  Contains 1 umuC domain

uniprot_information:
SwissProt: Q9UNA4 # The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity# Belongs to the DNA polymerase type-Y family &  Contains 1 umuC domain


uniprot_information_type: SwissProt: O95948
uniprot_information:
Belongs to the CUT homeobox family &  Contains 1 CUT DNA-binding domain &  Contains 1 homeobox DNA-binding domain


uniprot_information_type: SwissProt: Q96PU5
uniprot_information:
Contains 1 C2 domain &  Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain &  Contains 4 WW domains


uniprot_information_type:
SwissProt: Q6PKX4 # PTB domain mediates receptor interaction (By similarity)# Belongs to the DOK family. Type B subfamily &  Contains 1 IRS-type PTB domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q6PKX4 # PTB domain mediates receptor interaction (By similarity)# Belongs to the DOK family. Type B subfamily &  Contains 1 IRS-type PTB domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: O14544 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SH2 domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: O14544 # The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity)# Contains 1 SH2 domain &  Contains 1 SOCS box domain


uniprot_information_type: SwissProt: Q6ZSZ6
uniprot_information:
Belongs to the teashirt C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers &  Contains 1 homeobox DNA-binding domain


uniprot_information_type:
SwissProt: Q86XN8 # Binds RNA through its KH domains (By similarity)# Contains 2 KH domains &  Contains 1 RING-type zinc finger

uniprot_information:
SwissProt: Q86XN8 # Binds RNA through its KH domains (By similarity)# Contains 2 KH domains &  Contains 1 RING-type zinc finger


uniprot_information_type: SwissProt: Q13332
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily &  Contains 8 fibronectin type-III domains &  Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 2 tyrosine-protein phosphatase domains


uniprot_information_type: SwissProt: Q75N90
uniprot_information:
Belongs to the fibrillin family &  Contains 44 EGF-like domains &  Contains 9 TB (TGF-beta binding) domains


uniprot_information_type:
SwissProt: Q9H324 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix (By similarity)# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 5 TSP type-1 domains

uniprot_information:
SwissProt: Q9H324 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix (By similarity)# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 1 PLAC domain &  Contains 5 TSP type-1 domains


uniprot_information_type:
SwissProt: Q3MIN7 # The Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity (By similarity)# Contains 1 N-terminal Ras-GEF domain &  Contains 1 Ras-associating domain &  Contains 1 Ras-GEF domain

uniprot_information:
SwissProt: Q3MIN7 # The Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity (By similarity)# Contains 1 N-terminal Ras-GEF domain &  Contains 1 Ras-associating domain &  Contains 1 Ras-GEF domain


uniprot_information_type:
SwissProt: Q14576 # RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity)# Belongs to the RRM elav family &  Contains 3 RRM (RNA recognition motif) domains

uniprot_information:
SwissProt: Q14576 # RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in target mRNAs. RRM 3 binds to poly-A mRNA sequences (By similarity)# Belongs to the RRM elav family &  Contains 3 RRM (RNA recognition motif) domains


uniprot_information_type: SwissProt: O14787
uniprot_information:
Belongs to the importin beta family &  Contains 13 HEAT repeats &  Contains 1 importin N-terminal domain


uniprot_information_type:
SwissProt: Q9UHX3 # The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk &  Binding to chondroitin sulfate is mediated by the fourth EGF domain# Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 5 EGF-like domains &  Contains 1 GPS domain

uniprot_information:
SwissProt: Q9UHX3 # The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk &  Binding to chondroitin sulfate is mediated by the fourth EGF domain# Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily &  Contains 5 EGF-like domains &  Contains 1 GPS domain


uniprot_information_type: SwissProt: Q8IZJ3
uniprot_information:
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family &  Contains 1 Kazal-like domain


uniprot_information_type:
SwissProt: Q9UPW8 # The C2 domains are not involved in calcium-dependent phospholipid binding (By similarity) &  The C-terminal region containing both MHD domains and the third C2 domain is required for synaptic vesicle priming activity (By similarity)# Belongs to the unc-13 family &  Contains 3 C2 domains &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 MHD2 (MUNC13 homology domain 2) domain &  Contains 1 phorbol-ester/DAG-type zinc finger

uniprot_information:
SwissProt: Q9UPW8 # The C2 domains are not involved in calcium-dependent phospholipid binding (By similarity) &  The C-terminal region containing both MHD domains and the third C2 domain is required for synaptic vesicle priming activity (By similarity)# Belongs to the unc-13 family &  Contains 3 C2 domains &  Contains 1 MHD1 (MUNC13 homology domain 1) domain &  Contains 1 MHD2 (MUNC13 homology domain 2) domain &  Contains 1 phorbol-ester/DAG-type zinc finger


uniprot_information_type:
SwissProt: P42701 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 5 fibronectin type-III domains

uniprot_information:
SwissProt: P42701 # The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding &  The box 1 motif is required for JAK interaction and/or activation# Belongs to the type I cytokine receptor family. Type 2 subfamily &  Contains 5 fibronectin type-III domains


uniprot_information_type: SwissProt: Q86UW8
uniprot_information:
Belongs to the HAPLN family &  Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 2 Link domains


uniprot_information_type: SwissProt: Q05481
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 36 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: Q8IUC4
uniprot_information:
Belongs to the RHPN family &  Contains 1 BRO1 domain &  Contains 1 PDZ (DHR) domain &  Contains 1 REM (Hr1) repeat


uniprot_information_type:
SwissProt: Q8WU68 # The second zinc finger in necessary for interaction with GFI1 and for alternative pre-mRNA splicing events (By similarity)# Belongs to the splicing factor SR family &  Contains 2 C3H1-type zinc fingers &  Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q8WU68 # The second zinc finger in necessary for interaction with GFI1 and for alternative pre-mRNA splicing events (By similarity)# Belongs to the splicing factor SR family &  Contains 2 C3H1-type zinc fingers &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: Q8N205 # The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains (By similarity)# Belongs to the nesprin family &  Contains 1 KASH domain

uniprot_information:
SwissProt: Q8N205 # The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains (By similarity)# Belongs to the nesprin family &  Contains 1 KASH domain


uniprot_information_type:
SwissProt: Q96DZ5 # Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD)# Contains 3 ANK repeats &  Contains 2 CAP-Gly domains

uniprot_information:
SwissProt: Q96DZ5 # Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD)# Contains 3 ANK repeats &  Contains 2 CAP-Gly domains


uniprot_information_type: SwissProt: Q96SK3
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 20 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q8TDF6 # The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG# Belongs to the RASGRP family &  Contains 1 EF-hand domain &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 Ras-GEF domain

uniprot_information:
SwissProt: Q8TDF6 # The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG# Belongs to the RASGRP family &  Contains 1 EF-hand domain &  Contains 1 N-terminal Ras-GEF domain &  Contains 1 phorbol-ester/DAG-type zinc finger &  Contains 1 Ras-GEF domain


uniprot_information_type: SwissProt: Q6ZSI9
uniprot_information:
Belongs to the peptidase C2 family &  Contains 1 calpain catalytic domain &  Contains 1 EF-hand domain


uniprot_information_type:
SwissProt: Q9P244 # The PDZ-binding motif is required for neurite outgrowth promotion and for DLG1-, DLG3- and DLG4-binding (By similarity)# Belongs to the LRFN family &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 7 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q9P244 # The PDZ-binding motif is required for neurite outgrowth promotion and for DLG1-, DLG3- and DLG4-binding (By similarity)# Belongs to the LRFN family &  Contains 1 fibronectin type-III domain &  Contains 1 Ig-like (immunoglobulin-like) domain &  Contains 7 LRR (leucine-rich) repeats


uniprot_information_type: SwissProt: Q9Y6R6
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 23 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: P31751
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q9Y6R0 # The PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B# Contains 1 PID domain

uniprot_information:
SwissProt: Q9Y6R0 # The PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B# Contains 1 PID domain


uniprot_information_type:
SwissProt: Q8WXF8 # Interactions with CASP8 and CASP10 are mediated by the DED domain# Contains 1 DED (death effector) domain

uniprot_information:
SwissProt: Q8WXF8 # Interactions with CASP8 and CASP10 are mediated by the DED domain# Contains 1 DED (death effector) domain


uniprot_information_type: SwissProt: Q00889
uniprot_information:
Belongs to the immunoglobulin superfamily. CEA family &  Contains 3 Ig-like C2-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type: SwissProt: Q9UJW7
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 18 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q96B18 # The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins (By similarity)# Belongs to the dapper family

uniprot_information:
SwissProt: Q96B18 # The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins (By similarity)# Belongs to the dapper family


uniprot_information_type:
SwissProt: Q14003 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily

uniprot_information:
SwissProt: Q14003 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily


uniprot_information_type:
SwissProt: Q9NT99 # The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4 (By similarity)# Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 9 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: Q9NT99 # The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4 (By similarity)# Contains 1 Ig-like C2-type (immunoglobulin-like) domain &  Contains 9 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q9BQG1 # The first C2 domain mediates Ca(2+)-dependent phospholipid binding# Belongs to the synaptotagmin family &  Contains 2 C2 domains

uniprot_information:
SwissProt: Q9BQG1 # The first C2 domain mediates Ca(2+)-dependent phospholipid binding# Belongs to the synaptotagmin family &  Contains 2 C2 domains


uniprot_information_type:
SwissProt: Q9BS31 # The KRAB domain is required for transcriptional repression# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 10 C2H2-type zinc fingers &  Contains 1 KRAB domain

uniprot_information:
SwissProt: Q9BS31 # The KRAB domain is required for transcriptional repression# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 10 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: P59046
uniprot_information:
Belongs to the NLRP family &  Contains 1 DAPIN domain &  Contains 8 LRR (leucine-rich) repeats &  Contains 1 NACHT domain


uniprot_information_type:
SwissProt: Q6NZY7 # The CRIB domain mediates interaction with CDC42 (By similarity)# Belongs to the BORG/CEP family &  Contains 1 CRIB domain

uniprot_information:
SwissProt: Q6NZY7 # The CRIB domain mediates interaction with CDC42 (By similarity)# Belongs to the BORG/CEP family &  Contains 1 CRIB domain


uniprot_information_type: SwissProt: Q8WX94
uniprot_information:
Belongs to the NLRP family &  Contains 1 DAPIN domain &  Contains 9 LRR (leucine-rich) repeats &  Contains 1 NACHT domain


uniprot_information_type:
SwissProt: Q9Y2P7 # The KRAB domain mediates interaction with TRIM28 and is required for transcriptional repressor activity# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 15 C2H2-type zinc fingers &  Contains 1 KRAB domain

uniprot_information:
SwissProt: Q9Y2P7 # The KRAB domain mediates interaction with TRIM28 and is required for transcriptional repressor activity# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 15 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: Q96K62
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 4 C2H2-type zinc fingers


uniprot_information_type: SwissProt: Q15831
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q14011 # Both the RRM domain and the arginine, glycine (RGG) rich domain are necessary for binding to the TXN 3'-untranslated region. Both the RRM domain and the arginine, glycine (RGG) rich domain (RGG repeats) are necessary for optimal recruitment into SGs upon cellular stress. The C-terminal domain containing RGG repeats is necessary for translational repression (By similarity)# Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q14011 # Both the RRM domain and the arginine, glycine (RGG) rich domain are necessary for binding to the TXN 3'-untranslated region. Both the RRM domain and the arginine, glycine (RGG) rich domain (RGG repeats) are necessary for optimal recruitment into SGs upon cellular stress. The C-terminal domain containing RGG repeats is necessary for translational repression (By similarity)# Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: Q2TAK8 # The PWWP domain mediates the interaction with nucleosomes# Belongs to the MUM1 family &  Contains 1 PWWP domain

uniprot_information:
SwissProt: Q2TAK8 # The PWWP domain mediates the interaction with nucleosomes# Belongs to the MUM1 family &  Contains 1 PWWP domain


uniprot_information_type:
SwissProt: Q86WG3 # The CRAL-TRIO domain is known to bind small hydrophobic molecules (By similarity)# Contains 1 CRAL-TRIO domain

uniprot_information:
SwissProt: Q86WG3 # The CRAL-TRIO domain is known to bind small hydrophobic molecules (By similarity)# Contains 1 CRAL-TRIO domain


uniprot_information_type:
SwissProt: Q8N594 # The JAMM motif may mediate the protease activity (By similarity)# Belongs to the peptidase M67 family &  Contains 1 MPN (JAB/Mov34) domain

uniprot_information:
SwissProt: Q8N594 # The JAMM motif may mediate the protease activity (By similarity)# Belongs to the peptidase M67 family &  Contains 1 MPN (JAB/Mov34) domain


uniprot_information_type:
SwissProt: Q96T88 # The RING finger is required for ubiquitin ligase activity (By similarity) &  The YDG domain mediates the interaction with histone H3 (By similarity)# Contains 1 PHD-type zinc finger &  Contains 2 RING-type zinc fingers &  Contains 1 ubiquitin-like domain &  Contains 1 YDG domain

uniprot_information:
SwissProt: Q96T88 # The RING finger is required for ubiquitin ligase activity (By similarity) &  The YDG domain mediates the interaction with histone H3 (By similarity)# Contains 1 PHD-type zinc finger &  Contains 2 RING-type zinc fingers &  Contains 1 ubiquitin-like domain &  Contains 1 YDG domain


uniprot_information_type:
SwissProt: Q9P1Y5 # The CKK domain binds microtubules (By similarity)# Belongs to the CAMSAP1 family &  Contains 1 CH (calponin-homology) domain &  Contains 1 CKK domain

uniprot_information:
SwissProt: Q9P1Y5 # The CKK domain binds microtubules (By similarity)# Belongs to the CAMSAP1 family &  Contains 1 CH (calponin-homology) domain &  Contains 1 CKK domain


uniprot_information_type: SwissProt: O14733
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: P60323 # The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein (By similarity)# Belongs to the nanos family &  Contains 1 nanos-type zinc finger

uniprot_information:
SwissProt: P60323 # The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein (By similarity)# Belongs to the nanos family &  Contains 1 nanos-type zinc finger


uniprot_information_type: SwissProt: O14559
uniprot_information:
Belongs to the PX domain-containing GAP family &  Contains 1 PX (phox homology) domain &  Contains 1 Rho-GAP domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: P04632 # The contact of the 5th EF-hand domain from each monomer allows the formation of the homodimer and also appears to mediate the contact between the large catalytic subunit and small regulatory subunit for the formation of the heterodimer (By similarity)# Contains 5 EF-hand domains

uniprot_information:
SwissProt: P04632 # The contact of the 5th EF-hand domain from each monomer allows the formation of the homodimer and also appears to mediate the contact between the large catalytic subunit and small regulatory subunit for the formation of the heterodimer (By similarity)# Contains 5 EF-hand domains


uniprot_information_type:
SwissProt: Q8NA42 # The KRAB domain is responsible for the transcriptional repressor activity# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 11 C2H2-type zinc fingers &  Contains 1 KRAB domain

uniprot_information:
SwissProt: Q8NA42 # The KRAB domain is responsible for the transcriptional repressor activity# Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 11 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type:
SwissProt: Q3ZCQ8 # The FCP1 homology domain does not contain the canonical D-x-D-x-[TV] active site, suggesting that it probably does not display phosphatase activity in vivo# Belongs to the TIM50 family &  Contains 1 FCP1 homology domain

uniprot_information:
SwissProt: Q3ZCQ8 # The FCP1 homology domain does not contain the canonical D-x-D-x-[TV] active site, suggesting that it probably does not display phosphatase activity in vivo# Belongs to the TIM50 family &  Contains 1 FCP1 homology domain


uniprot_information_type:
SwissProt: Q9NYJ7 # The DSL domain is required for binding to the Notch receptor# Contains 1 DSL domain &  Contains 6 EGF-like domains

uniprot_information:
SwissProt: Q9NYJ7 # The DSL domain is required for binding to the Notch receptor# Contains 1 DSL domain &  Contains 6 EGF-like domains


uniprot_information_type: SwissProt: Q9H254
uniprot_information:
Belongs to the spectrin family &  Contains 2 CH (calponin-homology) domains &  Contains 1 PH domain &  Contains 18 spectrin repeats


uniprot_information_type: SwissProt: Q7Z7M0
uniprot_information:
Contains 2 CUB domains &  Contains 5 EGF-like domains &  Contains 12 Kelch repeats &  Contains 4 laminin EGF-like domains &  Contains 7 PSI domains


uniprot_information_type:
SwissProt: Q6P597 # The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity)# Belongs to the kinesin light chain family &  Contains 5 TPR repeats

uniprot_information:
SwissProt: Q6P597 # The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity)# Belongs to the kinesin light chain family &  Contains 5 TPR repeats


uniprot_information_type:
SwissProt: Q9HAP6 # The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane (By similarity) &  The PDZ domain regulates endocytosis and recycling of the receptor at the membrane (By similarity) &  The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes (By similarity)# Belongs to the lin-7 family &  Contains 1 L27 domain &  Contains 1 PDZ (DHR) domain

uniprot_information:
SwissProt: Q9HAP6 # The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane (By similarity) &  The PDZ domain regulates endocytosis and recycling of the receptor at the membrane (By similarity) &  The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes (By similarity)# Belongs to the lin-7 family &  Contains 1 L27 domain &  Contains 1 PDZ (DHR) domain


uniprot_information_type:
SwissProt: Q7Z406 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils (By similarity)# Contains 1 IQ domain &  Contains 1 myosin head-like domain

uniprot_information:
SwissProt: Q7Z406 # The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils (By similarity)# Contains 1 IQ domain &  Contains 1 myosin head-like domain


uniprot_information_type:
SwissProt: Q01892 # The protein contains a weakly acidic N-terminal transactivation domain (TAD) followed by a second TAD rich in proline, serine and threonine. Each of these domains may be required for transcriptional activation of a subset of target genes# Belongs to the ETS family &  Contains 1 ETS DNA-binding domain

uniprot_information:
SwissProt: Q01892 # The protein contains a weakly acidic N-terminal transactivation domain (TAD) followed by a second TAD rich in proline, serine and threonine. Each of these domains may be required for transcriptional activation of a subset of target genes# Belongs to the ETS family &  Contains 1 ETS DNA-binding domain


uniprot_information_type: SwissProt: Q96C55
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 A.T hook DNA-binding domain &  Contains 4 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q9Y6I3 # The NPF repeat domain is involved in EPS15 binding &  The DPW repeat domain is involved in AP2A2 and clathrin binding &  The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction with the AP-2 complex subunit AP2B1 (By similarity)# Belongs to the epsin family &  Contains 1 ENTH (epsin N-terminal homology) domain &  Contains 2 UIM (ubiquitin-interacting motif) repeats

uniprot_information:
SwissProt: Q9Y6I3 # The NPF repeat domain is involved in EPS15 binding &  The DPW repeat domain is involved in AP2A2 and clathrin binding &  The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction with the AP-2 complex subunit AP2B1 (By similarity)# Belongs to the epsin family &  Contains 1 ENTH (epsin N-terminal homology) domain &  Contains 2 UIM (ubiquitin-interacting motif) repeats


uniprot_information_type: SwissProt: Q5EBM4
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 3 C2H2-type zinc fingers &  Contains 1 KRAB domain


uniprot_information_type: SwissProt: Q8NHY6
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 15 C2H2-type zinc fingers &  Contains 2 KRAB domains


uniprot_information_type: SwissProt: Q96GC6
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 5 C2H2-type zinc fingers &  Contains 2 KRAB domains &  Contains 1 SCAN box domain


uniprot_information_type: SwissProt: P10073
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 8 C2H2-type zinc fingers &  Contains 1 SCAN box domain


uniprot_information_type:
SwissProt: Q2I0M5 # The FU repeat is required for activation and stabilization of beta-catenin (By similarity)# Belongs to the R-spondin family &  Contains 1 FU (furin-like) repeat &  Contains 1 TSP type-1 domain

uniprot_information:
SwissProt: Q2I0M5 # The FU repeat is required for activation and stabilization of beta-catenin (By similarity)# Belongs to the R-spondin family &  Contains 1 FU (furin-like) repeat &  Contains 1 TSP type-1 domain


uniprot_information_type: SwissProt: Q9P1W8
uniprot_information:
Contains 2 Ig-like C1-type (immunoglobulin-like) domains &  Contains 1 Ig-like V-type (immunoglobulin-like) domain


uniprot_information_type:
SwissProt: Q9BZ11 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain

uniprot_information:
SwissProt: Q9BZ11 # The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 EGF-like domain &  Contains 1 peptidase M12B domain


uniprot_information_type: SwissProt: Q9NPB8
uniprot_information:
Belongs to the glycerophosphoryl diester phosphodiesterase family &  Contains 1 CBM20 (carbohydrate binding type-20) domain &  Contains 1 GDPD domain


uniprot_information_type:
SwissProt: Q9BQL6 # The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain. The FERM domain contains the subdomains F1, F2 and F3. It is preceded by a F0 domain with a ubiquitin-like fold. The F0 domain is required for integrin activation and for localization at focal adhesions# Belongs to the kindlin family &  Contains 1 FERM domain &  Contains 1 PH domain

uniprot_information:
SwissProt: Q9BQL6 # The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain. The FERM domain contains the subdomains F1, F2 and F3. It is preceded by a F0 domain with a ubiquitin-like fold. The F0 domain is required for integrin activation and for localization at focal adhesions# Belongs to the kindlin family &  Contains 1 FERM domain &  Contains 1 PH domain


uniprot_information_type:
SwissProt: Q9NPJ1 # The substrate-binding apical domain region is sufficient for centrosomal association# Belongs to the TCP-1 chaperonin family

uniprot_information:
SwissProt: Q9NPJ1 # The substrate-binding apical domain region is sufficient for centrosomal association# Belongs to the TCP-1 chaperonin family


uniprot_information_type: SwissProt: Q96L93
uniprot_information:
Belongs to the kinesin-like protein family &  Contains 1 FHA domain &  Contains 1 kinesin-motor domain &  Contains 1 PX (phox homology) domain


uniprot_information_type: SwissProt: Q9NZR4
uniprot_information:
Belongs to the paired homeobox family &  Contains 1 CVC domain &  Contains 1 homeobox DNA-binding domain


uniprot_information_type:
SwissProt: Q9H6Q3 # The loss of the C-terminal domain partially abolishes the inhibitory function, but can be partially compensated by higher level of protein expression# Contains 1 SH2 domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q9H6Q3 # The loss of the C-terminal domain partially abolishes the inhibitory function, but can be partially compensated by higher level of protein expression# Contains 1 SH2 domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q9Y5Q3 # The leucine-zipper domain is involved in the interaction with LRPICD# Belongs to the bZIP family. Maf subfamily &  Contains 1 bZIP domain

uniprot_information:
SwissProt: Q9Y5Q3 # The leucine-zipper domain is involved in the interaction with LRPICD# Belongs to the bZIP family. Maf subfamily &  Contains 1 bZIP domain


uniprot_information_type:
SwissProt: Q9BR39 # The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids (By similarity)# Belongs to the junctophilin family &  Contains 8 MORN repeats

uniprot_information:
SwissProt: Q9BR39 # The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding, possibly by interacting with phospholipids (By similarity)# Belongs to the junctophilin family &  Contains 8 MORN repeats


uniprot_information_type:
SwissProt: Q9BR09 # The SOCS domain mediates the interaction with TCEB1 and TCEB2, while the NHR domain may be involved in ubiquitination substrate binding (By similarity)# Contains 1 NHR (neuralized homology repeat) domain &  Contains 1 SOCS box domain

uniprot_information:
SwissProt: Q9BR09 # The SOCS domain mediates the interaction with TCEB1 and TCEB2, while the NHR domain may be involved in ubiquitination substrate binding (By similarity)# Contains 1 NHR (neuralized homology repeat) domain &  Contains 1 SOCS box domain


uniprot_information_type:
SwissProt: Q9HCD5 # Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors#

uniprot_information:
SwissProt: Q9HCD5 # Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors#


uniprot_information_type: SwissProt: Q9ULU4
uniprot_information:
Contains 1 bromo domain &  Contains 1 MYND-type zinc finger &  Contains 1 PHD-type zinc finger &  Contains 1 PWWP domain


uniprot_information_type: SwissProt: Q8TCU6
uniprot_information:
Contains 1 DEP domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PDZ (DHR) domain &  Contains 2 PH domains


uniprot_information_type:
SwissProt: Q14721 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily

uniprot_information:
SwissProt: Q14721 # The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position &  The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments# Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily


uniprot_information_type:
SwissProt: Q13469 # Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors (By similarity)# Contains 1 RHD (Rel-like) domain

uniprot_information:
SwissProt: Q13469 # Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors (By similarity)# Contains 1 RHD (Rel-like) domain


uniprot_information_type:
SwissProt: Q969W9 # The WW-binding motifs mediate interaction with NEDD4 (By similarity)# Belongs to the PMEPA1 family

uniprot_information:
SwissProt: Q969W9 # The WW-binding motifs mediate interaction with NEDD4 (By similarity)# Belongs to the PMEPA1 family


uniprot_information_type:
SwissProt: Q9BYK8 # Contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. These motifs are not required for interaction with PPARG# Belongs to the DNA2/NAM7 helicase family &  Contains 1 C2H2-type zinc finger

uniprot_information:
SwissProt: Q9BYK8 # Contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. These motifs are not required for interaction with PPARG# Belongs to the DNA2/NAM7 helicase family &  Contains 1 C2H2-type zinc finger


uniprot_information_type:
SwissProt: Q7Z434 # Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58 and IFIH1# Contains 1 CARD domain

uniprot_information:
SwissProt: Q7Z434 # Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58 and IFIH1# Contains 1 CARD domain


uniprot_information_type: SwissProt: Q9H116
uniprot_information:
Belongs to the krueppel C2H2-type zinc-finger protein family &  Contains 1 BTB (POZ) domain &  Contains 10 C2H2-type zinc fingers


uniprot_information_type:
SwissProt: Q8IXJ9 # Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which may be required for an association with nuclear receptors# Belongs to the Asx family &  Contains 1 PHD-type zinc finger

uniprot_information:
SwissProt: Q8IXJ9 # Contains one Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which may be required for an association with nuclear receptors# Belongs to the Asx family &  Contains 1 PHD-type zinc finger


uniprot_information_type:
SwissProt: Q9H444 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components# Belongs to the SNF7 family

uniprot_information:
SwissProt: Q9H444 # The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components# Belongs to the SNF7 family


uniprot_information_type:
SwissProt: P17213 # The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested# Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family &  Contains 2 LRR (leucine-rich) repeats

uniprot_information:
SwissProt: P17213 # The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested# Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family &  Contains 2 LRR (leucine-rich) repeats


uniprot_information_type:
SwissProt: Q9BQK8 # Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity (By similarity) &  Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif (By similarity)# Belongs to the lipin family

uniprot_information:
SwissProt: Q9BQK8 # Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity (By similarity) &  Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif (By similarity)# Belongs to the lipin family


uniprot_information_type: SwissProt: Q4VXU2
uniprot_information:
Belongs to the polyadenylate-binding protein type-1 family &  Contains 1 PABC domain &  Contains 4 RRM (RNA recognition motif) domains


uniprot_information_type: SwissProt: Q13043
uniprot_information:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily &  Contains 1 protein kinase domain &  Contains 1 SARAH domain


uniprot_information_type:
SwissProt: Q8N6T3 # The region downstream of Arf-GAP domain is essential to GAP activity in vivo. This region may be required for its targeting to Golgi membranes (By similarity)# Contains 1 Arf-GAP domain

uniprot_information:
SwissProt: Q8N6T3 # The region downstream of Arf-GAP domain is essential to GAP activity in vivo. This region may be required for its targeting to Golgi membranes (By similarity)# Contains 1 Arf-GAP domain


uniprot_information_type: SwissProt: Q9P218
uniprot_information:
Contains 2 collagen-like domains &  Contains 6 fibronectin type-III domains &  Contains 1 TSP N-terminal (TSPN) domain &  Contains 1 VWFA domain


uniprot_information_type:
SwissProt: Q9UHI8 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 3 TSP type-1 domains

uniprot_information:
SwissProt: Q9UHI8 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 3 TSP type-1 domains


uniprot_information_type:
SwissProt: Q9UNA0 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 2 TSP type-1 domains

uniprot_information:
SwissProt: Q9UNA0 # The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix &  The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme# Contains 1 disintegrin domain &  Contains 1 peptidase M12B domain &  Contains 2 TSP type-1 domains


uniprot_information_type: SwissProt: O95104
uniprot_information:
Belongs to the splicing factor SR family &  Contains 1 CID domain &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type: SwissProt: P22102
uniprot_information:
In the N-terminal section; belongs to the GARS family &  In the central section; belongs to the AIR synthase family &  In the C-terminal section; belongs to the GART family &  Contains 1 ATP-grasp domain


uniprot_information_type:
SwissProt: Q01196 # A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes# Contains 1 Runt domain

uniprot_information:
SwissProt: Q01196 # A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes# Contains 1 Runt domain


uniprot_information_type:
SwissProt: O60469 # Ig-like C2-type domains 7 to 9 are sufficient for interaction with NTN1 and commissural axon outgrowth. The transmembrane domain is necessary for interaction with DCC (By similarity)# Contains 6 fibronectin type-III domains &  Contains 10 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: O60469 # Ig-like C2-type domains 7 to 9 are sufficient for interaction with NTN1 and commissural axon outgrowth. The transmembrane domain is necessary for interaction with DCC (By similarity)# Contains 6 fibronectin type-III domains &  Contains 10 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type: SwissProt: P57078
uniprot_information:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family &  Contains 10 ANK repeats &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q01081 # The C-terminal SR-rich domain is required for interactions with SR proteins and the splicing regulators TRA and TRA2, and the N-terminal domain is required for formation of the U2AF1/U2AF2 heterodimer# Belongs to the splicing factor SR family &  Contains 2 C3H1-type zinc fingers &  Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q01081 # The C-terminal SR-rich domain is required for interactions with SR proteins and the splicing regulators TRA and TRA2, and the N-terminal domain is required for formation of the U2AF1/U2AF2 heterodimer# Belongs to the splicing factor SR family &  Contains 2 C3H1-type zinc fingers &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type: SwissProt: O95954
uniprot_information:
In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family &  In the N-terminal section; belongs to the formiminotransferase family


uniprot_information_type: SwissProt: Q9UHP3
uniprot_information:
Belongs to the peptidase C19 family &  Contains 1 UBA-like domain &  Contains 2 UIM (ubiquitin-interacting motif) repeats


uniprot_information_type:
SwissProt: P78310 # The Ig-like C2-type 1 domain probably mediates homodimerization and interaction with JAML &  The PDZ-binding motif mediates interaction with MPDZ and BAIAP1# Contains 2 Ig-like C2-type (immunoglobulin-like) domains

uniprot_information:
SwissProt: P78310 # The Ig-like C2-type 1 domain probably mediates homodimerization and interaction with JAML &  The PDZ-binding motif mediates interaction with MPDZ and BAIAP1# Contains 2 Ig-like C2-type (immunoglobulin-like) domains


uniprot_information_type:
SwissProt: Q9Y5T5 # The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin# Belongs to the peptidase C19 family. USP16 subfamily &  Contains 1 UBP-type zinc finger

uniprot_information:
SwissProt: Q9Y5T5 # The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin# Belongs to the peptidase C19 family. USP16 subfamily &  Contains 1 UBP-type zinc finger


uniprot_information_type:
SwissProt: P18583 # Contains 8 types of repeats which are distributed in 3 regions# Contains 1 DRBM (double-stranded RNA-binding) domain &  Contains 1 G-patch domain

uniprot_information:
SwissProt: P18583 # Contains 8 types of repeats which are distributed in 3 regions# Contains 1 DRBM (double-stranded RNA-binding) domain &  Contains 1 G-patch domain


uniprot_information_type:
SwissProt: Q15811 # SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin (By similarity). SH3-1 and SH3-4 bind to ARHGAP31 &  The KLERQ domain binds to SNAP-25 and SNAP-23 (By similarity)# Contains 1 C2 domain &  Contains 1 DH (DBL-homology) domain &  Contains 2 EF-hand domains &  Contains 2 EH domains &  Contains 1 PH domain &  Contains 5 SH3 domains

uniprot_information:
SwissProt: Q15811 # SH3-3, SH3-4 and SH3-5, but not SH3-1 and SH3-2 domains, bind to dynamin (By similarity). SH3-1 and SH3-4 bind to ARHGAP31 &  The KLERQ domain binds to SNAP-25 and SNAP-23 (By similarity)# Contains 1 C2 domain &  Contains 1 DH (DBL-homology) domain &  Contains 2 EF-hand domains &  Contains 2 EH domains &  Contains 1 PH domain &  Contains 5 SH3 domains


uniprot_information_type:
SwissProt: Q96NY7 # Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity)# Belongs to the chloride channel CLIC family &  Contains 1 GST C-terminal domain

uniprot_information:
SwissProt: Q96NY7 # Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity)# Belongs to the chloride channel CLIC family &  Contains 1 GST C-terminal domain


uniprot_information_type:
SwissProt: Q9NRZ7 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

uniprot_information:
SwissProt: Q9NRZ7 # The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity)# Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


uniprot_information_type:
SwissProt: O95613 # Composed of a coiled-coil central region flanked by non-helical N- and C-terminals#

uniprot_information:
SwissProt: O95613 # Composed of a coiled-coil central region flanked by non-helical N- and C-terminals#


uniprot_information_type:
SwissProt: P55957 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family#

uniprot_information:
SwissProt: P55957 # Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family#


uniprot_information_type:
SwissProt: P28482 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain

uniprot_information:
SwissProt: P28482 # The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases# Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily &  Contains 1 protein kinase domain


uniprot_information_type:
SwissProt: Q8IU80 # Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s) (By similarity)# Belongs to the peptidase S1 family &  Contains 2 CUB domains &  Contains 3 LDL-receptor class A domains &  Contains 1 peptidase S1 domain

uniprot_information:
SwissProt: Q8IU80 # Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s) (By similarity)# Belongs to the peptidase S1 family &  Contains 2 CUB domains &  Contains 3 LDL-receptor class A domains &  Contains 1 peptidase S1 domain


uniprot_information_type:
SwissProt: Q6UXY1 # The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity)# Contains 1 IMD (IRSp53/MIM homology) domain &  Contains 1 SH3 domain

uniprot_information:
SwissProt: Q6UXY1 # The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity)# Contains 1 IMD (IRSp53/MIM homology) domain &  Contains 1 SH3 domain


uniprot_information_type:
SwissProt: Q8NET5 # The ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions. The phosphorylated ITAM domain binds ZAP70 and SYK# Contains 1 Ig-like V-type (immunoglobulin-like) domain &  Contains 1 ITAM domain

uniprot_information:
SwissProt: Q8NET5 # The ITAM domain displays no close similarity to any existing ITAMs, except for four conserved positions. The phosphorylated ITAM domain binds ZAP70 and SYK# Contains 1 Ig-like V-type (immunoglobulin-like) domain &  Contains 1 ITAM domain


uniprot_information_type:
SwissProt: Q9ULC8 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily &  Contains 1 DHHC-type zinc finger

uniprot_information:
SwissProt: Q9ULC8 # The DHHC domain is required for palmitoyltransferase activity (By similarity)# Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily &  Contains 1 DHHC-type zinc finger


uniprot_information_type:
SwissProt: Q96NN9 # The Rieske domain induces apoptosis# Belongs to the FAD-dependent oxidoreductase family &  Contains 1 Rieske domain

uniprot_information:
SwissProt: Q96NN9 # The Rieske domain induces apoptosis# Belongs to the FAD-dependent oxidoreductase family &  Contains 1 Rieske domain


uniprot_information_type: SwissProt: Q13356
uniprot_information:
Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily &  Contains 1 PPIase cyclophilin-type domain &  Contains 1 U-box domain


uniprot_information_type:
SwissProt: P11274 # The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene &  The DH domain is involved in interaction with CCPG1 (By similarity)# Contains 1 C2 domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 Rho-GAP domain

uniprot_information:
SwissProt: P11274 # The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene &  The DH domain is involved in interaction with CCPG1 (By similarity)# Contains 1 C2 domain &  Contains 1 DH (DBL-homology) domain &  Contains 1 PH domain &  Contains 1 Rho-GAP domain


uniprot_information_type: SwissProt: Q9UGT4
uniprot_information:
Contains 1 AMOP domain &  Contains 1 SMB (somatomedin-B) domain &  Contains 1 Sushi (CCP/SCR) domain &  Contains 1 VWFD domain


uniprot_information_type: SwissProt: P35626
uniprot_information:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily &  Contains 1 AGC-kinase C-terminal domain &  Contains 1 PH domain &  Contains 1 protein kinase domain &  Contains 1 RGS domain


uniprot_information_type:
SwissProt: Q01844 # EWS activation domain (EAD) functions as a potent activation domain in EFPS. EWSR1 binds POLR2C but not POLR2E or POLR2G, whereas the isolated EAD binds POLR2E and POLR2G but not POLR2C. Cis-linked RNA-binding domain (RBD) can strongly and specifically repress trans-activation by the EAD# Belongs to the RRM TET family &  Contains 1 IQ domain &  Contains 1 RanBP2-type zinc finger &  Contains 1 RRM (RNA recognition motif) domain

uniprot_information:
SwissProt: Q01844 # EWS activation domain (EAD) functions as a potent activation domain in EFPS. EWSR1 binds POLR2C but not POLR2E or POLR2G, whereas the isolated EAD binds POLR2E and POLR2G but not POLR2C. Cis-linked RNA-binding domain (RBD) can strongly and specifically repress trans-activation by the EAD# Belongs to the RRM TET family &  Contains 1 IQ domain &  Contains 1 RanBP2-type zinc finger &  Contains 1 RRM (RNA recognition motif) domain


uniprot_information_type:
SwissProt: Q86V35 # The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting# Contains 2 EF-hand domains

uniprot_information:
SwissProt: Q86V35 # The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting# Contains 2 EF-hand domains


uniprot_information_type: SwissProt: Q13615
uniprot_information:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily &  Contains 1 FYVE-type zinc finger &  Contains 1 myotubularin phosphatase domain


uniprot_information_type:
SwissProt: Q9H2D6 # Contains at least 2 actin-binding sites per coiled-coil dimer# Contains 1 PH domain

uniprot_information:
SwissProt: Q9H2D6 # Contains at least 2 actin-binding sites per coiled-coil dimer# Contains 1 PH domain


uniprot_information_type:
SwissProt: Q9NS69 # Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins# Belongs to the Tom22 family

uniprot_information:
SwissProt: Q9NS69 # Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex (By similarity). The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins# Belongs to the Tom22 family


uniprot_information_type:
SwissProt: Q9Y512 # Its C-terminal part seems to contain many membrane-spanning sided beta-sheets, that have the potential to adopt a transmembrane beta-barrel type structure (By similarity)# Belongs to the SAM50/omp85 family

uniprot_information:
SwissProt: Q9Y512 # Its C-terminal part seems to contain many membrane-spanning sided beta-sheets, that have the potential to adopt a transmembrane beta-barrel type structure (By similarity)# Belongs to the SAM50/omp85 family


uniprot_information_type: SwissProt: Q86V86
uniprot_information:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily &  Contains 1 protein kinase domain


uniprot_information_type: SwissProt: Q9BYB0
uniprot_information:
Contains 6 ANK repeats &  Contains 1 PDZ (DHR) domain &  Contains 1 SAM (sterile alpha motif) domain &  Contains 1 SH3 domain


# go_bp

go_id: GO:0021813
evidence: IEA
term:
cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration


go_id: GO:0051482
evidence: IEA
term:
elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger


go_id: GO:0021882
evidence: IEA
term:
regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment


go_id: GO:0060665
evidence: IEA
term:
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling


go_id: GO:0007200
evidence: IDA
term:
activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger


go_id: GO:0006978
evidence: IDA
term:
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator


go_id: GO:0021913
evidence: IEA
term:
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification


go_id: GO:0060528
evidence: IEA
term:
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development


go_id: GO:0002025
evidence: IEA
term:
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure


go_id: GO:0021912
term:
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification


go_id: GO:0021918
term:
regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment


go_id: GO:0060668
evidence: IEA
term:
regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling


go_id: GO:0002581
evidence: IDA
term:
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II


# go_mf

go_id: GO:0016702
evidence: IEA
term:
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen


go_id: GO:0016705
evidence: IEA
term:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen


go_id: GO:0016706
evidence: IEA
term:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors


go_id: GO:0008457
evidence: IDA
term:
beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity


go_id: GO:0045155
evidence: IDA
term:
electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity


go_id: GO:0047290
evidence: IEA
term:
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity


go_id: GO:0016717
term:
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water


