@article{Cowtan2006, abstract = {A new technique for the automated tracing of protein chains in experimental electron-density maps is described. The technique relies on the repeated application of an oriented electron-density likelihood target function to identify likely C(alpha) positions. This function is applied both in the location of a few promising ;seed' positions in the map and to grow those initial C(alpha) positions into extended chain fragments. Techniques for assembling the chain fragments into an initial chain trace are discussed.}, author = {Cowtan, Kevin}, doi = {10.1107/S0907444906022116}, issn = {0907-4449 (Print)}, journal = {Acta crystallographica. Section D, Biological crystallography}, keywords = {Algorithms,Automation,Bacillus subtilis,Computational Biology,Crystallography, X-Ray,Mixed Function Oxygenases,Models, Molecular,Models, Statistical,Models, Theoretical,Molecular Conformation,Probability,Proteins,Proteomics,Software,chemistry,enzymology,methods}, language = {eng}, month = sep, number = {Pt 9}, pages = {1002--1011}, pmid = {16929101}, title = {{The Buccaneer software for automated model building. 1. Tracing protein chains.}}, volume = {62}, year = {2006} }