@article{Skubak2010,
abstract = {Density modification is a standard technique in macromolecular crystallography that can significantly improve an initial electron-density map. To obtain optimal results, the initial and density-modified map are combined. Current methods assume that these two maps are independent and propagate the initial map information and its accuracy indirectly through previously determined coefficients. A multivariate equation has been derived that no longer assumes independence between the initial and density-modified map, considers the observed diffraction data directly and refines the errors that can occur in a single-wavelength anomalous diffraction experiment. The equation has been implemented and tested on over 100 real data sets. The results are dramatic: the method provides significantly improved maps over the current state of the art and leads to many more structures being built automatically.},
author = {Skubak, Pavol and Waterreus, Willem Jan and Pannu, Navraj S},
doi = {10.1107/S0907444910014642},
issn = {1399-0047 (Electronic)},
journal = {Acta crystallographica. Section D, Biological crystallography},
keywords = {Algorithms,Crystallography, X-Ray,Models, Molecular,Multivariate Analysis,methods},
language = {eng},
month = jul,
number = {Pt 7},
pages = {783--788},
pmid = {20606258},
title = {{Multivariate phase combination improves automated crystallographic model building.}},
volume = {66},
year = {2010}
}