@article{Cowtan2010,
abstract = {Classical density-modification techniques (as opposed to statistical approaches) offer a computationally cheap method for improving phase estimates in order to provide a good electron-density map for model building. The rise of statistical methods has lead to a shift in focus away from the classical approaches; as a result, some recent developments have not made their way into classical density-modification software. This paper describes the application of some recent techniques, including most importantly the use of prior phase information in the likelihood estimation of phase errors within a classical density-modification framework. The resulting software gives significantly better results than comparable classical methods, while remaining nearly two orders of magnitude faster than statistical methods.},
author = {Cowtan, Kevin},
doi = {10.1107/S090744490903947X},
issn = {1399-0047},
journal = {Acta crystallographica. Section D, Biological crystallography},
number = {Pt 4},
pages = {470--8},
pmid = {20383000},
publisher = {International Union of Crystallography},
title = {{Recent developments in classical density modification.}},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20383000},
volume = {66},
year = {2010}
}