PMID- 12351820 OWN - NLM STAT- MEDLINE DA - 20020927 DCOM- 20030409 LR - 20070724 IS - 0907-4449 (Print) IS - 0907-4449 (Linking) VI - 58 IP - Pt 10 Pt 2 DP - 2002 Oct TI - Substructure solution with SHELXD. PG - 1772-9 AB - Iterative dual-space direct methods based on phase refinement in reciprocal space and peak picking in real space are able to locate relatively large numbers of anomalous scatterers efficiently from MAD or SAD data. Truncation of the data at a particular resolution, typically in the range 3.0-3.5 A, can be critical to success. The efficiency can be improved by roughly an order of magnitude by Patterson-based seeding instead of starting from random phases or sites; Patterson superposition methods also provide useful validation. The program SHELXD implementing this approach is available as part of the SHELX package. FAU - Schneider, Thomas R AU - Schneider TR AD - Department of Structural Chemistry, Gottingen University, Tammannstrasse 4, D-37077 Gottingen, Germany. FAU - Sheldrick, George M AU - Sheldrick GM LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20020928 PL - Denmark TA - Acta Crystallogr D Biol Crystallogr JT - Acta crystallographica. Section D, Biological crystallography JID - 9305878 RN - 0 (Solutions) SB - IM MH - Crystallography, X-Ray/methods MH - Models, Molecular MH - Molecular Conformation MH - *Molecular Structure MH - Reproducibility of Results MH - Scattering, Radiation MH - Sensitivity and Specificity MH - *Software MH - Solutions MH - Thermodynamics EDAT- 2002/09/28 04:00 MHDA- 2003/04/10 05:00 CRDT- 2002/09/28 04:00 PHST- 2002/05/30 [received] PHST- 2002/07/02 [accepted] PHST- 2002/09/28 [epublish] AID - S0907444902011678 [pii] PST - ppublish SO - Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 2):1772-9. Epub 2002 Sep 28.