@article{Abrahams1997,
abstract = {The chemical, physical and symmetry constraints of an electron-density map impose relationships between structure factors, and these relationships are exploited during refinement. However, constraints often allow an artificially high correlation between the model and the original structure factors, a flaw known as model or refinement bias. Elimination of the bias component of a constrained model, the component insensitive to constraints, enhances the power of phase-refinement techniques. The scale of the bias component, here denoted as gamma, is shown to be equal in magnitude to the origin vector of the interference function G that defines the relationships between the structure factors. The gamma correction leads to solvent flipping in the case of phase improvement by solvent flattening, and other types of constraint allow a similar treatment.},
author = {Abrahams, J P},
doi = {10.1107/S0907444996015272},
file = {:home/palo/.local/share/data/Mendeley Ltd./Mendeley Desktop/Downloaded/Abrahams - 1997 - Bias reduction in phase refinement by modified interference functions introducing the gamma correction.pdf:pdf},
issn = {0907-4449},
journal = {Acta crystallographica. Section D, Biological crystallography},
number = {Pt 4},
pages = {371--6},
pmid = {15299902},
publisher = {International Union of Crystallography},
title = {{Bias reduction in phase refinement by modified interference functions: introducing the gamma correction.}},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15299902},
volume = {53},
year = {1997}
}