Anatomist is capable of managing several referential systems for the same object (an object is an entity such as a imaging volume, a mesh, a graph of ROIs....), in other words it can immerse objects into different coordinate systems if you have a transformation file (.trm) which contains a transformation matrix. For example, if you know which transformation is required to switch from your image's coordinate system to a normalized coordinate system (for example the Talairach referential), then you can display your volume into this coordinate system. To read more information about referential, you can see Aims training referentials chapter.